CDS2 Gene
protein-coding GIFtS: 57
GCID: GC20P005107
|
|
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase)...
| |
Aliases
for CDS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 21 2 | | CTP:Phosphatidate Cytidylyltransferase 22 3 | | CDP-DAG Synthase 22 3 | | EC 2.7.7.413 8 | | CDP-DG Synthase 22 3 | | CDP-DG Synthetase 22 | | CDP-Diacylglycerol Synthase 22 3 | | CDP-Diglyceride Diphosphorylase 22 | | CDP-Diglyceride Pyrophosphorylase 22 3 | | CDP-Diglyceride Synthetase 22 | | CDP-Diglyceride Synthase 22 3 | | Phosphatidate Cytidylyltransferase 22 | | CDS 22 3 | | EC 2.7.78 |
Export aliases for CDS2 gene to outside databasesPrevious GC identifers: GC20P005095 GC20P005102 GC20P005055 |
Summaries
for CDS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDS2:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many Gprotein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase Cactivity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling bycatalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane proteinlocalized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to beinvolved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmicreticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identifiedin humans, one mapping to human chromosome 4q21 and a second to 20p13. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674Function: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol,phosphatidylglycerol, and cardiolipin
Gene Wiki entry for CDS2
|
Genomic Views
for CDS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDS2 gene promoter:
Nkx3-1 LHX3b/Lhx3b AML1a Nkx3-1 v1 Nkx3-1 v2 PPAR-gamma1 Nkx3-1 v3 LHX3a/Lhx3a SEF-1 (1) PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p13CDS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P005107: view genomic region
(about GC identifiers)
Start:
|
5,107,432 bp from pter |
End:
|
5,178,533 bp from pter |
Size:
|
71,102 bases |
Orientation:
|
plus strand |
|
Proteins
for CDS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674 (See
protein sequence)Recommended Name: Phosphatidate cytidylyltransferase 2 Size: 445 amino acids; 51418 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side (Potential)
Developmental stage: No expression detected at E10.5 in the developing brain. At E12.5 expression is detected in thedeveloping sentral nervous system and peripheral nervous system. At E17.5 high levels of expression are detected in anumber of sites, including the dorsal root ganglia of the peripheral nervous system and the ganglion cell layer of theneural retina in the developing eye. At this stage expression in the brain is restricted to the ventricular zone ofthe telencephalon, in particular in the basal ganglia and the cerebral cortex
Secondary accessions: B2RDC6 D3DW04 Q5TDY2 Q5TDY3 Q5TDY4 Q5TDY5 Q9BYK5 Q9NTT2Alternative splicing: 2 isoforms: O95674-1 O95674-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CDS2: NX_O95674
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95674
4/16 DME Specific Peptides for CDS2 (O95674) (see all 16)
CDS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003809.1
ENSEMBL proteins: ENSP00000419879 ENSP00000403205 ENSP00000368352 ENSP00000440555 Reactome Protein details: O95674
Human Recombinant Protein Products for CDS2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
TAS | -- | | GO:0005783 | endoplasmic reticulum |
IEA | -- | | GO:0016021 | integral to membrane |
NAS | -- |
CDS2 for ontologies About GeneDecksing
CDS2 Antibody Products:
Assay Products for CDS2: |
Protein
Domains /
Families
for CDS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDS2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95674ProtoNet protein and cluster: O95674 1 Blocks protein family: IPB000374 Phosphatidate cytidylyltransferase
UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674Similarity: Belongs to the CDS family |
Function
for CDS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CDS2_HUMAN, O95674Function: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol,phosphatidylglycerol, and cardiolipinCatalytic activity: CTP + phosphatidate = diphosphate + CDP-diacylglycerol Genatlas biochemistry entry for CDS2:CDP-diacylglycerol synthase (CDS) 2,photoreceptor specific,highly expressed in the differentiating neuroblasts of theneural retina and central nervous system embryo,regulator of cellular phosphatidylinositol content,involved inphosphoinositide mediated signaling pathway
Enzyme Numbers (IUBMB): EC 2.7.7.411 2 EC 2.7.72
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004605 | phosphatidate cytidylyltransferase activity |
NAS | 9806839 |
CDS2 for ontologies About GeneDecksing
Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cds2):
CDS2 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDS2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDS2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDS2 (NM_003818) | |  | Sino Biological Human cDNA Clone for CDS2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDS2 |
|
Pathways & Interactions
for CDS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycerophospholipid biosynthesis | | | 2 | Metabolism | | | 3 | CDP-diacylglycerol biosynthesis I | | | 4 | Inositol phosphate metabolism | | | 5 | choline biosynthesis III | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for CDS2
5 
Reactome Pathways for CDS2
3 
Kegg Pathways (Kegg details for CDS2):
UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:step 3/3
CDS2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/39 Interacting proteins for CDS2 (O956743 ENSP000004198794) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006655 | phosphatidylglycerol biosynthetic process |
TAS | -- | | GO:0008654 | phospholipid biosynthetic process |
NAS | -- | | GO:0016024 | CDP-diacylglycerol biosynthetic process |
IEA | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
CDS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDS2 for compounds About GeneDecksing
 Browse Tocris compounds for CDS2
10/898 HMDB Compounds for CDS2 (see all 898) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| DG(16:0e/18:0/0:0) | 2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2) | -- | 12486725 | | CDP-DG(16:0/16:0) | CDP-DG(16:0/16:0) (see all 6) | -- | -- | | CDP-DG(16:0/18:0) | CDP-DG(34:0) (see all 6) | -- | -- | | CDP-DG(16:0/18:1(11Z)) | CDP-Diacylglycerol(16:0/18:1w7) (see all 10) | -- | -- | | CDP-DG(16:0/18:1(9Z)) | 1-palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate (see all 10) | -- | -- | | CDP-DG(16:0/18:2(9Z,12Z)) | 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP (see all 10) | -- | -- | | CDP-DG(16:0/20:4(5Z,8Z,11Z,14Z)) | CDP-Diacylglycerol(16:0/20:4n6) (see all 10) | -- | -- | | CDP-DG(16:0/20:4(8Z,11Z,14Z,17Z)) | CDP-Diacylglycerol(16:0/20:4) (see all 12) | -- | -- | | CDP-DG(16:0/22:3(10Z,13Z,16Z)) | CDP-DG(16:0/22:3n6) (see all 10) | -- | -- | | CDP-DG(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-cytidine-5'-diphosphate (see all 10) | -- | -- |
1 Novoseek chemical compound relationship for CDS2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cdpdiacylglycerol |
96.8 |
4 |
9407135 (1), 9889000 (1), 20126473 (1), 9806839 (1) |
Search CenterWatch for drugs/clinical trials and news about CDS2
|
Transcripts
for CDS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDS2 gene: NM_003818.3 Unigene Cluster for CDS2: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 Hs.126857 [show with all ESTs]Unigene Representative Sequence: NM_0038188 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460006(uc002wls.3 uc002wlw.3 uc002wlv.3 uc010zqv.2)
ENST00000467923 ENST00000450570 ENST00000468817(uc002wlr.2) ENST00000486875
ENST00000379070 ENST00000379062 ENST00000535100
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDS2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDS2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDS2 (NM_003818) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDS2 |
Additional cDNA sequence: AF069532.1 AK001414.1 AK022998.1 AK027196.1 AK027695.1 AK091045.1 AK095430.1 AK123831.1 AK130193.1 AK303426.1 AK304763.1 AK315489.1 BC015432.1 BC025346.1 BC044234.1 Y16521.1 21 DOTS entries: DT.447713 DT.452484 DT.100811623 DT.97823544 DT.100811627 DT.120809416 DT.40301466 DT.100811628 DT.100811625 DT.86847184 DT.97798693 DT.121642091 DT.40281368 DT.100761888 DT.100832707 DT.91750025 DT.97841297 DT.120809572 DT.120825812 DT.121619555 DT.87011406 24/197 AceView cDNA sequences (see all 197): CB151613 BE887496 CR624244 BI757475 AA668759 BI908957 BM835862 CB995826 BM547481 BX354911 CD244786 BE327687 BM785892 AL529301 AW051893 AI498667 AA906803 CB992614 CR590453 Z40923 AL541594 BP350818 AK027695 AI418750
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CDS2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDS2
|
Expression
for CDS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATACTGTA
About this image
See CDS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDS2
SOURCE GeneReport for Unigene cluster: Hs.126857
UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674Tissue specificity: Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung,liver, skeletal muscle, kidney and pancreas
SABiosciences Custom PCR Arrays for CDS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDS2 |
Orthologs
for CDS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CDS2 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDS21 |
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) more |
81(n)
91.4(a) |
|
419517 XM_417669.3 XP_417669.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CDS26 |
-- |
81(a) |
1 ↔ 1 |
AAWZ02041731(418-5255) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC055505.12 |
-- |
79.66(n) |
|
394161 BC055505.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CdsA3 |
phototransduction phosphatidate
cytidylyltransferase |
58(a) |
|
66B7 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C33H5.18a3 |
CDP-diacylglycerol synthase |
51(a)
(best of 2) |
|
IV(7813373-7815920) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CDS21 |
cytidinediphosphate diacylglycerol synthase 2 |
50.7(n)
44.26(a) |
|
828329 NM_001036620.1 NP_001031697.1 |
rice
(Oryza sativa) |
Liliopsida |
Os10g03273001 |
hypothetical protein |
50.53(n)
42.65(a) |
|
4348326 NM_001070890.1 NP_001064355.1 |
ENSEMBL Gene Tree for CDS2 (if available)
TreeFam Gene Tree for CDS2 (if available) |
Paralogs
for CDS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDS2 gene
- CDS12
1 SIMAP similar gene for CDS2 using alignment to 3 protein entries: CDS2_HUMAN (see all proteins):CDS1
CDS2 for paralogs About GeneDecksing
|
Genomic Variants
for CDS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDS2 (5107432 - 5178533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDS2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDS2 |
|
Disorders
/ Diseases
for CDS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDS2 for disorders About GeneDecksing
OMIM gene information: 603549
OMIM disorders: --
3  diseases for CDS2: About MalaCardsimperforate anus cerebritis malaria
Human Genome Epidemiology (HuGE) Navigator: CDS2 (4 documents)
Export disorders for CDS2 gene to outside databases
|
Publications
for CDS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDS2 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with CDS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. (PubMed id 9889000)1, 2, 3, 9 Volta M.... Franco B. (1999)
- Isolation and chromosomal localization of two human CDP- diacylglycerol synthase (CDS) genes. (PubMed id 9806839)1, 2, 3, 9 Halford S.... Hunt D.M. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PubMed id 9407135)1, 9 Lykidis A.... Jackowski S. (1997)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for CDS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDS2 gene:
Search GeneIP for patents involving CDS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDS2 | | | OriGene Protein Over-expression Lysate for CDS2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CDS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDS2 | | OriGene Custom Protein Services for CDS2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDS2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CDS2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CDS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDS2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CDS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDS2 |
| |  | |
|
|
|
