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CDS2 Gene

protein-coding   GIFtS: 62
GCID: GC20P005107

CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase)...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 21 2     CTP:Phosphatidate Cytidylyltransferase 22 3
CDP-DAG Synthase 22 3     EC 2.7.7.413 8
CDP-DG Synthase 22 3     CDP-DG Synthetase 22
CDP-Diacylglycerol Synthase 22 3     CDP-Diglyceride Diphosphorylase 22
CDP-Diglyceride Pyrophosphorylase 22 3     CDP-Diglyceride Synthetase 22
CDP-Diglyceride Synthase 22 3     Phosphatidate Cytidylyltransferase 22
CDS 22 3     EC 2.7.78

External Ids:    HGNC: 18011   Entrez Gene: 87602   Ensembl: ENSG000001012907   OMIM: 6035495   UniProtKB: O956743   

Export aliases for CDS2 gene to outside databases

Previous GC identifers: GC20P005095 GC20P005102 GC20P005055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDS2 Gene:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G
protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C
activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling
by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane
protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is
thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the
endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme
have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CDS2 Gene:
CDS2 (CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2) is a protein-coding gene. Diseases associated with CDS2 include imperforate anus, and cerebritis. GO annotations related to this gene include phosphatidate cytidylyltransferase activity. An important paralog of this gene is CDS1.

UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674
Function: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol,
phosphatidylglycerol, and cardiolipin

Gene Wiki entry for CDS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDS2 gene promoter:
         Nkx3-1   LHX3b/Lhx3b   AML1a   Nkx3-1 v1   Nkx3-1 v2   PPAR-gamma1   Nkx3-1 v3   LHX3a/Lhx3a   SEF-1 (1)   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDS2 promoter sequence
   Search Chromatin IP Primers for CDS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p13

CDS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDS2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P005107:  view genomic region     (about GC identifiers)

Start:
5,107,407 bp from pter      End:
5,178,533 bp from pter
Size:
71,127 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674 (See protein sequence)
Recommended Name: Phosphatidate cytidylyltransferase 2  
Size: 445 amino acids; 51418 Da
Developmental stage: No expression detected at E10.5 in the developing brain. At E12.5 expression is detected in
the developing sentral nervous system and peripheral nervous system. At E17.5 high levels of expression are
detected in a number of sites, including the dorsal root ganglia of the peripheral nervous system and the
ganglion cell layer of the neural retina in the developing eye. At this stage expression in the brain is
restricted to the ventricular zone of the telencephalon, in particular in the basal ganglia and the cerebral
cortex
Secondary accessions: B2RDC6 D3DW04 Q5TDY2 Q5TDY3 Q5TDY4 Q5TDY5 Q9BYK5 Q9NTT2
Alternative splicing: 2 isoforms:  O95674-1   O95674-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDS2: NX_O95674

Explore proteomics data for CDS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys367
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDS2 (O95674) (see all 16)
     MDRFDCQ  NYFFYGE  AESAPLP  YHRFISF 


    See CDS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003809.1  
    ENSEMBL proteins: 
     ENSP00000419879   ENSP00000403205   ENSP00000368352   ENSP00000440555  
    Reactome Protein details: O95674

    CDS2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CDS2

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    Cloud-Clone Corp. CLIAs for CDS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000374 PC_trans
     IPR016720 PC_Trfase_euk

    Graphical View of Domain Structure for InterPro Entry O95674

    ProtoNet protein and cluster: O95674

    1 Blocks protein domain: IPB000374 Phosphatidate cytidylyltransferase

    UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674
    Similarity: Belongs to the CDS family


    CDS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDS2_HUMAN, O95674
    Function: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol,
    phosphatidylglycerol, and cardiolipin
    Catalytic activity: CTP + phosphatidate = diphosphate + CDP-diacylglycerol

         Genatlas biochemistry entry for CDS2:
    CDP-diacylglycerol synthase (CDS) 2,photoreceptor specific,highly expressed in the differentiating neuroblasts of
    the neural retina and central nervous system embryo,regulator of cellular phosphatidylinositol content,involved
    in phosphoinositide mediated signaling pathway

         Enzyme Numbers (IUBMB): EC 2.7.7.411 2 EC 2.7.72

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004605phosphatidate cytidylyltransferase activity NAS9806839
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    CDS2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cds2):
     hematopoietic system  immune system  mortality/aging  nervous system 

    CDS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDS2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDS2

    miRNA
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    miRTarBase miRNAs that target CDS2:
    hsa-mir-320a (MIRT044394), hsa-mir-484 (MIRT041676), hsa-mir-16-5p (MIRT032053)

    Block miRNA regulation of human, mouse, rat CDS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDS2 (see all 84):
    hsa-miR-582-3p hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-3074-3p hsa-miR-3613-3p hsa-miR-3148 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCDS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDS2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CDS2 (NM_003818)
    Sino Biological Human cDNA Clone for CDS2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDS2_HUMAN, O95674: Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    endoplasmic reticulum2
    cytosol1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CDS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PG0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    CDP-diacylglycerol biosynthesis I0.00
    4Inositol phosphate metabolism (KEGG)
    Phosphatidylinositol signaling system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CDS2
        CDP-diacylglycerol biosynthesis I
    phosphatidylglycerol biosynthesis II (non-plastidic)


    1 Reactome Pathway for CDS2
        Synthesis of PG


    3 Kegg Pathways  (Kegg details for CDS2):
        Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 3/3


    CDS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDS2
    Interactions:

        Search GeneGlobe Interaction Network for CDS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDS2 (O956743 ENSP000004198794) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYS1Q8N2H43, ENSP000002439184I2D: score=1 STRING: ENSP00000243918
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    SCAMP1O151263I2D: score=1 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006655phosphatidylglycerol biosynthetic process TAS--
    GO:0008654phospholipid biosynthetic process ----
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--
    GO:0044281small molecule metabolic process TAS--

    CDS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDS2

    Selected HMDB Compounds for CDS2 (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    CDP-DG(16:0/16:0)CDP-DG(16:0/16:0) (see all 6)----
    CDP-DG(16:0/18:0)CDP-DG(34:0) (see all 6)----
    CDP-DG(16:0/18:1(11Z))CDP-Diacylglycerol(16:0/18:1w7) (see all 10)----
    CDP-DG(16:0/18:1(9Z))1-palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate (see all 10)----
    CDP-DG(16:0/18:2(9Z,12Z))1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP (see all 10)----
    CDP-DG(16:0/20:4(5Z,8Z,11Z,14Z))CDP-Diacylglycerol(16:0/20:4n6) (see all 10)----
    CDP-DG(16:0/20:4(8Z,11Z,14Z,17Z))CDP-Diacylglycerol(16:0/20:4) (see all 12)----
    CDP-DG(16:0/22:3(10Z,13Z,16Z))CDP-DG(16:0/22:3n6) (see all 10)----
    CDP-DG(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-cytidine-5'-diphosphate (see all 10)----

    1 Novoseek inferred chemical compound relationship for CDS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cdpdiacylglycerol 96.8 4 9407135 (1), 9889000 (1), 20126473 (1), 9806839 (1)



    CDS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDS2 gene: 
    NM_003818.3  

    Unigene Cluster for CDS2:

    CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
    Hs.126857  [show with all ESTs]
    Unigene Representative Sequence: NM_003818
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460006(uc002wls.3 uc002wlw.3 uc002wlv.3 uc010zqv.2)
    ENST00000467923 ENST00000450570 ENST00000468817(uc002wlr.2) ENST00000486875
    ENST00000379070 ENST00000379062 ENST00000535100
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDS2 (see all 84):
    hsa-miR-582-3p hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-3074-3p hsa-miR-3613-3p hsa-miR-3148 hsa-miR-761
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CDS2

    Additional mRNA sequence: 

    AF069532.1 AK001414.1 AK022998.1 AK027196.1 AK027695.1 AK091045.1 AK095430.1 AK123831.1 
    AK130193.1 AK303426.1 AK304763.1 AK315489.1 BC015432.1 BC025346.1 BC044234.1 Y16521.1 

    20 DOTS entries:

    DT.447713  DT.452484  DT.100811623  DT.97823544  DT.100811627  DT.120809416  DT.40301466  DT.100811628 
    DT.100811625  DT.86847184  DT.97798693  DT.121642091  DT.40281368  DT.100761888  DT.100832707  DT.91750025 
    DT.120809572  DT.120825812  DT.121619555  DT.87011406 

    Selected AceView cDNA sequences (see all 197):

    BX354911 AI418750 CR597119 BM554949 BF434936 AI016680 NM_003818 AL529301 
    CD244786 BU634195 BQ015343 AA906803 CB995826 BM785892 BE887496 BE327687 
    CR604132 AL540147 CR624244 AI659086 BX394103 CR622068 BC025751 BU543834 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDS2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                -                 -     -                                   -                       -           -                 -         
    SP2:                                -                 -     -                                   -                       -           -                           
    SP3:                                                  -     -                                   -                                                               
    SP4:                                                                                            -                       -           -                           
    SP5:                                -     -           -     -                                   -                                                               


    ECgene alternative splicing isoforms for CDS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATACTGTA
    CDS2 Expression
    About this image


    CDS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    CDS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126857

    UniProtKB/Swiss-Prot: CDS2_HUMAN, O95674
    Tissue specificity: Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta,
    lung, liver, skeletal muscle, kidney and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDS2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cds21 , 5 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) more1, 5 88.74(n)1
    96.4(a)1
      2 (64.15 cM)5
    1109111  NM_138651.61  NP_619592.11 
     1322631485 
    chicken
    (Gallus gallus)
    Aves CDS21 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) more 81(n)
    91.4(a)
      419517  XM_417669.4  XP_417669.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDS26
    CDP-diacylglycerol synthase (phosphatidate cytidyl...
    82(a)
    1 ↔ 1
    AAWZ02041731(418-5255)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cds21 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) more 78.64(n)
    87.73(a)
      100144929  NM_001126503.1  NP_001119975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055505.12   -- 79.66(n)   394161  BC055505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CdsA3 phototransduction phosphatidate
    cytidylyltransferase
    58(a)   66B7   --
    worm
    (Caenorhabditis elegans)
    Secernentea C33H5.18a3 CDP-diacylglycerol synthase 51(a)
    (best of 2)
      IV(7813373-7815920)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDS16
    Phosphatidate cytidylyltransferase (CDP-diglycerid...
    34(a)
    1 → many
    II(296369-297742) YBR029C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDS11 CDS1 49.58(n)
    42.89(a)
      842541  NM_104923.3  NP_176433.2 


    ENSEMBL Gene Tree for CDS2 (if available)
    TreeFam Gene Tree for CDS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDS2 gene
    CDS12  
    1 SIMAP similar gene for CDS2 using alignment to 3 protein entries:     CDS2_HUMAN (see all proteins):
    CDS1

    CDS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDS2 (see all 1669)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130437691,2
    C,F,A--5109269(+) GAGAAC/AATTTA 1 -- int18Minor allele frequency- A:0.30NA WA CSA 248
    rs20839191,2
    C,F--5109402(-) TGCATA/GCTCAC 1 -- int19Minor allele frequency- G:0.36NA WA CSA 252
    rs1846875731,2
    --5109470(+) GACTTC/TGTGGA 1 -- int10--------
    rs20839181,2
    C,F,H--5109512(-) TATCAT/CGCCTT 1 -- int112Minor allele frequency- C:0.21NS EA NA WA CSA 668
    rs1142485641,2
    C,F--5109732(+) AGGTGC/TACTTA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs60531271,2
    C,F,A,H--5109789(+) GTGGCG/ATGTTG 1 -- int18Minor allele frequency- A:0.09NS EA WA CSA 536
    rs736028781,2
    C--5109815(+) CTGCTG/ATGCAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1466794161,2
    --5109894(+) TCTCAA/GTTGTC 1 -- int10--------
    rs1155524491,2
    F--5109934(+) TTATTA/TTTTTT 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1891061411,2
    --5110079(+) CACCAC/TGCTCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CDS2 (5107407 - 5178533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656923CNV Deletion23128226
    nsv428375CNV Loss18775914
    nsv912632CNV Gain21882294
    nsv912629CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603549    OMIM disorders: --

    7 diseases for CDS2:    
    About MalaCards
    imperforate anus    cerebritis    tonsillitis    neuroblastoma
    endotheliitis    thyroiditis    prostatitis


    CDS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDS2
    Human Genome Epidemiology (HuGE) Navigator: CDS2 (4 documents)

    Export disorders for CDS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDS2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CDS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. (PubMed id 9889000)1, 2, 3, 9 Volta M.... Franco B. (Genomics 1999)
    2. Isolation and chromosomal localization of two human CDP- diacylglycerol synthase (CDS) genes. (PubMed id 9806839)1, 2, 3, 9 Halford S.... Hunt D.M. (Genomics 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PubMed id 9407135)1, 9 Lykidis A.... Jackowski S. (J. Biol. Chem. 1997)
    10. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8760 HGNC: 1801 AceView: CDS2 Ensembl:ENSG00000101290 euGenes: HUgn8760
    ECgene: CDS2 Kegg: 8760 H-InvDB: CDS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDS2 gene:
    Search GeneIP for patents involving CDS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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