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Aliases for CDS1 Gene

Aliases for CDS1 Gene

  • CDP-Diacylglycerol Synthase 1 2 3 4 5
  • CTP:Phosphatidate Cytidylyltransferase 1 3 4
  • CDP-Diglyceride Pyrophosphorylase 1 3 4
  • CDP-Diglyceride Synthase 1 3 4
  • CDP-DAG Synthase 1 3 4
  • CDP-DG Synthase 1 3 4
  • EC 2.7.7.41 4 61
  • CDS 1 3 4
  • CDS 3 4
  • CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 1 3
  • Phosphatidate Cytidylyltransferase 1 3
  • Phosphatidate Cytidylyltransferase 2
  • CDP-Diglyceride Synthetase 1 3
  • CDP-DG Synthetase 1 3

External Ids for CDS1 Gene

Previous GeneCards Identifiers for CDS1 Gene

  • GC04P085428
  • GC04P085797
  • GC04P085962
  • GC04P085861
  • GC04P081245

Summaries for CDS1 Gene

Entrez Gene Summary for CDS1 Gene

  • Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDS1 Gene

CDS1 (CDP-Diacylglycerol Synthase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphatidate cytidylyltransferase activity. An important paralog of this gene is CDS2.

UniProtKB/Swiss-Prot for CDS1 Gene

  • Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Gene Wiki entry for CDS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDS1 Gene

Genomics for CDS1 Gene

Regulatory Elements for CDS1 Gene

Enhancers for CDS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F084531 0.6 ENCODE 16.6 -51.3 -51275 1.1 ZNF263 PKNOX1 GFI1B FEZF1 ZBTB40 NR2F2 OSR2 JUND CTBP1 GATA3 CDS1 NKX6-1 WDFY3-AS2 RPL3P13
GH04F084631 0.9 ENCODE 11.1 +49.1 49064 1.5 ZNF316 RAD51 FOS CDS1 PIR31866 LOC102723338
GH04F084649 0.2 Ensembl 10.9 +66.6 66597 0.2 ZNF512 NR2F2 CDS1 PIR31866 LOC102723338
GH04F084647 0.4 ENCODE 10.9 +64.6 64559 0.2 MAFK CDS1 PIR31866 LOC102723338
GH04F084690 1.1 Ensembl ENCODE 10.9 +108.5 108490 2.1 JUN CEBPB SIN3A EP300 ARID1B JUND SCRT2 NFE2 FOS MAFK CDS1 WDFY3-AS1 WDFY3-AS2 PIR54500
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDS1 on UCSC Golden Path with GeneCards custom track

Promoters for CDS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001244498 596 2201 ATF1 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 GLIS2 FOS ZNF263 SP3

Genomic Location for CDS1 Gene

Chromosome:
4
Start:
84,582,904 bp from pter
End:
84,651,340 bp from pter
Size:
68,437 bases
Orientation:
Plus strand

Genomic View for CDS1 Gene

Genes around CDS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDS1 Gene

Proteins for CDS1 Gene

  • Protein details for CDS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92903-CDS1_HUMAN
    Recommended name:
    Phosphatidate cytidylyltransferase 1
    Protein Accession:
    Q92903
    Secondary Accessions:
    • B2RAL5
    • O00163

    Protein attributes for CDS1 Gene

    Size:
    461 amino acids
    Molecular mass:
    53304 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with FOS; this interaction may enhance catalytic activity.

neXtProt entry for CDS1 Gene

Post-translational modifications for CDS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDS1 Gene

Domains & Families for CDS1 Gene

Protein Domains for CDS1 Gene

Suggested Antigen Peptide Sequences for CDS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92903

UniProtKB/Swiss-Prot:

CDS1_HUMAN :
  • Belongs to the CDS family.
Family:
  • Belongs to the CDS family.
genes like me logo Genes that share domains with CDS1: view

No data available for Gene Families for CDS1 Gene

Function for CDS1 Gene

Molecular function for CDS1 Gene

GENATLAS Biochemistry:
CDP-diacylglycerol synthase (CDS) 1,photoreceptor specific,highly expressed in photoreceptor layer of adult retina,regulator of cellular phosphatidylinositol content,involved in phosphoinositide mediated signaling pathway
UniProtKB/Swiss-Prot CatalyticActivity:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
UniProtKB/Swiss-Prot Function:
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Enzyme Numbers (IUBMB) for CDS1 Gene

Gene Ontology (GO) - Molecular Function for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004142 diacylglycerol cholinephosphotransferase activity NAS 9115637
GO:0004605 phosphatidate cytidylyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CDS1: view
genes like me logo Genes that share phenotypes with CDS1: view

Animal Model Products

miRNA for CDS1 Gene

miRTarBase miRNAs that target CDS1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDS1 Gene

Localization for CDS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDS1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDS1 Gene COMPARTMENTS Subcellular localization image for CDS1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDS1: view

Pathways & Interactions for CDS1 Gene

genes like me logo Genes that share pathways with CDS1: view

UniProtKB/Swiss-Prot Q92903-CDS1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

SIGNOR curated interactions for CDS1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006655 phosphatidylglycerol biosynthetic process IBA --
GO:0006657 CDP-choline pathway IEA --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007165 signal transduction NAS 9115637
genes like me logo Genes that share ontologies with CDS1: view

Drugs & Compounds for CDS1 Gene

(4) Drugs for CDS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Cytidine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(60) Additional Compounds for CDS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CDP-DG(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/16:0)
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
CDP-DG(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:0)
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
CDP-DG(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n7)
  • CDP-DG(16:0/18:1w7)
CDP-DG(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n9)
  • CDP-DG(16:0/18:1w9)
CDP-DG(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2n6)
  • CDP-DG(16:0/18:2w6)
genes like me logo Genes that share compounds with CDS1: view

Transcripts for CDS1 Gene

Unigene Clusters for CDS1 Gene

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for CDS1 Gene

GeneLoc Exon Structure for
CDS1
ECgene alternative splicing isoforms for
CDS1

Expression for CDS1 Gene

mRNA expression in normal human tissues for CDS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDS1 Gene

This gene is overexpressed in Nasal epithelium (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDS1 Gene



Protein tissue co-expression partners for CDS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDS1 Gene:

CDS1

SOURCE GeneReport for Unigene cluster for CDS1 Gene:

Hs.654899

mRNA Expression by UniProt/SwissProt for CDS1 Gene:

Q92903-CDS1_HUMAN
Tissue specificity: Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.
genes like me logo Genes that share expression patterns with CDS1: view

Primer Products

No data available for mRNA differential expression in normal tissues for CDS1 Gene

Orthologs for CDS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDS1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia CDS1 34 35
  • 94.22 (n)
cow
(Bos Taurus)
Mammalia CDS1 34 35
  • 92.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDS1 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDS1 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cds1 34 16 35
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Cds1 34
  • 86.04 (n)
chicken
(Gallus gallus)
Aves CDS1 34 35
  • 77.85 (n)
lizard
(Anolis carolinensis)
Reptilia CDS1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cds1 34
  • 74.66 (n)
zebrafish
(Danio rerio)
Actinopterygii cds1 34 35
  • 72.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007175 34
  • 54.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CdsA 36 34 35
  • 54.75 (n)
worm
(Caenorhabditis elegans)
Secernentea C33H5.18 34
  • 55.84 (n)
C33H5.18a 36
  • 53 (a)
C33H5.18b 36
  • 53 (a)
cdgs-1 35
  • 48 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL084W 34
  • 49.14 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24640g 34
  • 48.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDS1 34 35 37
  • 48.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26770 34
  • 49.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11292 34
rice
(Oryza sativa)
Liliopsida Os01g0758400 34
  • 51.12 (n)
Os.15356 34
barley
(Hordeum vulgare)
Liliopsida Hv.4226 34
wheat
(Triticum aestivum)
Liliopsida Ta.6386 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 59 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13A2.03 34
  • 50 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09643 34
  • 49.09 (n)
Species where no ortholog for CDS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDS1 Gene

ENSEMBL:
Gene Tree for CDS1 (if available)
TreeFam:
Gene Tree for CDS1 (if available)

Paralogs for CDS1 Gene

Paralogs for CDS1 Gene

(1) SIMAP similar genes for CDS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDS1: view

Variants for CDS1 Gene

Sequence variations from dbSNP and Humsavar for CDS1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036129 A breast cancer sample
rs10000060 -- 84,620,245(+) tgaga(C/T)ggagt intron-variant
rs10006466 -- 84,624,283(+) AAAAA(A/C)AAACA intron-variant
rs10014792 -- 84,614,995(+) tctga(C/T)ggtat intron-variant
rs10020892 -- 84,616,667(+) CTGCT(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDS1 Gene

Variant ID Type Subtype PubMed ID
esv2727911 CNV deletion 23290073
esv3569548 CNV loss 25503493
esv3601225 CNV loss 21293372
nsv4406 CNV insertion 18451855

Variation tolerance for CDS1 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDS1 Gene

Disorders for CDS1 Gene

Relevant External Links for CDS1

Genetic Association Database (GAD)
CDS1
Human Genome Epidemiology (HuGE) Navigator
CDS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDS1

No disorders were found for CDS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDS1 Gene

Publications for CDS1 Gene

  1. Isolation and chromosomal localization of two human CDP- diacylglycerol synthase (CDS) genes. (PMID: 9806839) Halford S. … Hunt D.M. (Genomics 1998) 2 3 4 22 64
  2. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. (PMID: 9115637) Weeks R. … Leung D.W. (DNA Cell Biol. 1997) 2 3 4 22 64
  3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A. … Jackowski S. (J. Biol. Chem. 1997) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CDS1 Gene

Sources for CDS1 Gene

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