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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDS1 Gene

protein-coding   GIFtS: 65
GCID: GC04P085428

CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase)...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 11 2     CDS 12 3
CDS2 3     CTP:Phosphatidate Cytidylyltransferase 12 3
CDP-DAG Synthase 12 3     EC 2.7.7.413 8
CDP-DG Synthase 12 3     CDP-DG Synthetase 12
CDP-Diacylglycerol Synthase 12 3     CDP-Diglyceride Synthetase 12
CDP-Diglyceride Pyrophosphorylase 12 3     Phosphatidate Cytidylyltransferase 12
CDP-Diglyceride Synthase 12 3     

External Ids:    HGNC: 18001   Entrez Gene: 10402   Ensembl: ENSG000001636247   OMIM: 6035485   UniProtKB: Q929033   

Export aliases for CDS1 gene to outside databases

Previous GC identifers: GC04P085797 GC04P085962 GC04P085861 GC04P081245


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDS1 Gene:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G
protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C
activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling
by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane
protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is
thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the
endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme
have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CDS1 Gene: 
CDS1 (CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1) is a protein-coding gene. Diseases associated with CDS1 include chek2-related susceptibility to breast cancer, and chek2-related susceptibility to breast and colorectal cancer, and among its related super-pathways are Glycerophospholipid biosynthesis and Metabolic pathways. GO annotations related to this gene include phosphatidate cytidylyltransferase activity and diacylglycerol cholinephosphotransferase activity. An important paralog of this gene is CDS2.

UniProtKB/Swiss-Prot: CDS1_HUMAN, Q92903
Function: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns),
phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines.
May also play an important role in the signal transduction mechanism of retina and neural cells

Gene Wiki entry for CDS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDS1 gene promoter:
         C/EBPbeta   FOXD3   MIF-1   Arnt   AREB6   PPAR-gamma1   IRF-7A   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21

CDS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDS1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P085428:  view genomic region     (about GC identifiers)

Start:
85,504,057 bp from pter      End:
85,572,493 bp from pter
Size:
68,437 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDS1_HUMAN, Q92903 (See protein sequence)
Recommended Name: Phosphatidate cytidylyltransferase 1  
Size: 461 amino acids; 53304 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with FOS; this interaction may enhance catalytic activity (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
Note=Cytoplasmic aspect of the endoplasmic reticulum (By similarity)
Secondary accessions: B2RAL5 O00163

Explore the universe of human proteins at neXtProt for CDS1: NX_Q92903

Explore proteomics data for CDS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92903

  • 4/11 DME Specific Peptides for CDS1 (Q92903) (see all 11)
     MDRFDCQ  YHRFISF  NYFFYGE  FVLSLVKK 

    CDS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDS1 Protein Expression
    REFSEQ proteins: NP_001254.2  
    ENSEMBL proteins: 
     ENSP00000295887   ENSP00000421316  
    Reactome Protein details: Q92903
    Human Recombinant Protein Products for CDS1: 
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    Cloud-Clone Corp. Proteins for CDS1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    CDS1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CDS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000374 PC_trans
     IPR016720 PC_Trfase_euk

    Graphical View of Domain Structure for InterPro Entry Q92903

    ProtoNet protein and cluster: Q92903

    1 Blocks protein domain: IPB000374 Phosphatidate cytidylyltransferase

    UniProtKB/Swiss-Prot: CDS1_HUMAN, Q92903
    Similarity: Belongs to the CDS family


    CDS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDS1_HUMAN, Q92903
    Function: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns),
    phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines.
    May also play an important role in the signal transduction mechanism of retina and neural cells
    Catalytic activity: CTP + phosphatidate = diphosphate + CDP-diacylglycerol

         Genatlas biochemistry entry for CDS1:
    CDP-diacylglycerol synthase (CDS) 1,photoreceptor specific,highly expressed in photoreceptor layer of adult
    retina,regulator of cellular phosphatidylinositol content,involved in phosphoinositide mediated signaling pathway

         Enzyme Number (IUBMB): EC 2.7.7.411 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004142diacylglycerol cholinephosphotransferase activity NAS9115637
    GO:0004605phosphatidate cytidylyltransferase activity TAS--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    CDS1 for ontologies           About GeneDecksing


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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDS1 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCDS1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3CDP-diacylglycerol biosynthesis I
    CDP-diacylglycerol biosynthesis I0.94
    phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    4Inositol phosphate metabolism
    Phosphatidylinositol signaling system0.61
    5Synthesis of PI
    Synthesis of PI

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CDS1
        CDP-diacylglycerol biosynthesis I
    phosphatidylglycerol biosynthesis II (non-plastidic)

    5        Reactome Pathways for CDS1
        Glycerophospholipid biosynthesis
    Synthesis of PI
    Metabolism
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins


    3         Kegg Pathways  (Kegg details for CDS1):
        Glycerophospholipid metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: CDS1_HUMAN, Q92903
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 3/3


    CDS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for CDS1 (Q929033 ENSP000002958874) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRLS1Q9UJA23, ENSP000003681404I2D: score=1 STRING: ENSP00000368140
    CDIPTO147353, ENSP000002197894I2D: score=1 STRING: ENSP00000219789
    AGPAT4Q9NRZ53, ENSP000003140364I2D: score=1 STRING: ENSP00000314036
    RPSAP088653I2D: score=2 
    ACACBO007633I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006657CDP-choline pathway NAS9115637
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0007165signal transduction NAS9115637
    GO:0007602phototransduction NAS9806839

    CDS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDS1

    10/899 HMDB Compounds for CDS1 (see all 899)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    CDP-DG(16:0/16:0)CDP-DG(16:0/16:0) (see all 6)----
    CDP-DG(16:0/18:0)CDP-DG(34:0) (see all 6)----
    CDP-DG(16:0/18:1(11Z))CDP-Diacylglycerol(16:0/18:1w7) (see all 10)----
    CDP-DG(16:0/18:1(9Z))1-palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate (see all 10)----
    CDP-DG(16:0/18:2(9Z,12Z))1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP (see all 10)----
    CDP-DG(16:0/20:4(5Z,8Z,11Z,14Z))CDP-Diacylglycerol(16:0/20:4n6) (see all 10)----
    CDP-DG(16:0/20:4(8Z,11Z,14Z,17Z))CDP-Diacylglycerol(16:0/20:4) (see all 12)----
    CDP-DG(16:0/22:3(10Z,13Z,16Z))CDP-DG(16:0/22:3n6) (see all 10)----
    CDP-DG(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-cytidine-5'-diphosphate (see all 10)----

    4 Novoseek inferred chemical compound relationships for CDS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cdpdiacylglycerol 97.5 17 9806839 (3), 16023307 (2), 9407135 (1), 7816135 (1) (see all 8)
    pip2 75.4 3 16023307 (1), 17151285 (1), 9806839 (1)
    cardiolipin 73 3 9115637 (1), 17364441 (1), 19001357 (1)
    phosphatidylinositol 52.8 4 9407135 (2), 9115637 (1), 17364441 (1)

    Search CenterWatch for drugs/clinical trials and news about CDS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDS1 gene: 
    NM_001263.3  

    Unigene Cluster for CDS1:

    CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
    Hs.654899  [show with all ESTs]
    Unigene Representative Sequence: NM_001263
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295887(uc011ccv.2 uc010ike.1) ENST00000511298
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    Additional mRNA sequence: 

    AK026697.1 AK314245.1 AY312584.1 BC074833.2 BC074881.2 U60808.1 U65887.1 

    5 DOTS entries:

    DT.413575  DT.95370009  DT.100756695  DT.101957649  DT.100756697 

    24/146 AceView cDNA sequences (see all 146):

    BU679187 AI611167 AI978745 NM_001263 BQ184151 BE504303 AI306156 AA877270 
    AA410685 BU608894 CD367918 AA523952 CB306214 AW770312 AW418884 AI637714 
    AA164884 BM764996 AI765853 BE503109 AW862287 BF059302 BF064105 AW304313 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDS1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                    
    SP2:              -                                                                     


    ECgene alternative splicing isoforms for CDS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDS1 expression in normal human tissues (normalized intensities)      CDS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTCTGGAG
    CDS1 Expression
    About this image


    CDS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 6 entries
             Ureter
             visceral organ   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             brain/hindbrain   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             visceral organ/metanephros/calyx   
     
     Intestine
             Human Villous Capillary Endothelial Cells (HVCEC)   
             small intestine   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See CDS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDS1

    SOURCE GeneReport for Unigene cluster: Hs.654899

    UniProtKB/Swiss-Prot: CDS1_HUMAN, Q92903
    Tissue specificity: Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and
    prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDS1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cds11 , 5 CDP-diacylglycerol synthase 11, 5 86.62(n)1
    95.88(a)1
      5 (48.93 cM)5
    745961  NM_173370.31  NP_775546.21 
     1017651305 
    chicken
    (Gallus gallus)
    Aves CDS11 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) more 80.05(n)
    86.7(a)
      422611  XM_420571.3  XP_420571.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDS16
    Phosphatidate cytidylyltransferase
    84(a)
    1 ↔ 1
    5(43887468-43914988)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000020151 CDP-diacylglycerol synthase 1-like 72.52(n)
    78.98(a)
      100002015  XM_001341863.3  XP_001341899.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CdsA1 , 3 phototransduction phosphatidate
    cytidylyltransferase3
    CDP diglyceride synthetase1
    57(a)3
    54.75(n)1
    58.37(a)1
      66B73
    439501  NM_079922.31  NP_524661.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C33H5.18a3
    C33H5.181
    CDP-diacylglycerol synthase3
    Protein C33H5.181
    53(a)
    (best of 2)3
    55.84(n)1
    54(a)1
      IV(7813373-7815920)3
    35650461  NM_068897.21  NP_501298.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDS1(YBR029C)4
    CDS11
    Phosphatidate cytidylyltransferase (CDP-diglyceride more4
    Cds1p1
    49.1(n)1
    40.66(a)1
      2(297742-296369)4
    8523171, 4  NP_009585.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G267701 phosphatidate cytidylyltransferase 52.68(n)
    42.23(a)
      828784  NM_118811.6  NP_194407.5 
    rice
    (Oryza sativa)
    Liliopsida Os.153562 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 78.44(n)    AK059301.1 


    ENSEMBL Gene Tree for CDS1 (if available)
    TreeFam Gene Tree for CDS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDS1 gene
    CDS22  
    1 SIMAP similar gene for CDS1 using alignment to 2 protein entries:     CDS1_HUMAN (see all proteins):
    CDS2

    CDS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1356 SNPs in CDS1 are shown (see all 1356)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361294
    A breast cancer sample4--see VAR_0361292 K T mis40--------
    rs1893488521,2
    --85502065(+) TATCCA/CCACTG 1 -- us2k10--------
    rs1404383871,2
    --85502617(+) GGATTC/TTGATC 1 -- us2k10--------
    rs1821845491,2
    --85502627(+) CGTCTA/GAGAGC 1 -- us2k10--------
    rs1872221741,2
    --85502690(+) GAGGGC/TTAATA 1 -- us2k10--------
    rs1455337131,2
    --85502763(+) AGAGAA/GTTAGA 1 -- us2k10--------
    rs1388249071,2
    C--85502848(+) TTATTC/TTGATT 1 -- us2k10--------
    rs1179239991,2
    F--85502934(+) ATAGTT/CCTCTG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1173855721,2
    F--85502949(+) GTAGGG/TACTTA 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs117267441,2
    C,F,H--85502950(+) TAGGGA/GCTTAT 1 -- us2k19Minor allele frequency- G:0.04NS EA CSA WA NA 661

    HapMap Linkage Disequilibrium report for CDS1 (85504057 - 85572493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2727911CNV Deletion23290073
    nsv4406CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDS1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603548    OMIM disorders: --

    9 diseases for CDS1:    About MalaCards
    chek2-related susceptibility to breast cancer    chek2-related susceptibility to breast and colorectal cancer    li-fraumeni syndrome, chek2-related    prostate cancer
    retinal degeneration    retinitis    breast cancer    prostatitis
    neuronitis


    CDS1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CDS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 72.2 6 7816135 (1), 16023307 (1), 17151285 (1), 9806839 (1)

    Genetic Association Database (GAD): CDS1
    Human Genome Epidemiology (HuGE) Navigator: CDS1 (140 documents)

    Export disorders for CDS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDS1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CDS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. (PubMed id 9115637)1, 2, 3, 9 Weeks R....Leung D.W. (1997)
    2. Isolation and chromosomal localization of two human CDP- diacylglycerol synthase (CDS) genes. (PubMed id 9806839)1, 2, 3, 9 Halford S.... Hunt D.M. (1998)
    3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PubMed id 9407135)1, 2, 9 Lykidis A.... Jackowski S. (1997)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cloning of CDP-diacylglycerol synthase from a human neuronal cell line. (PubMed id 8863531)1, 2 Heacock A.M.... Agranoff B.W. (1996)
    7. Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. (PubMed id 9889000)1, 9 Volta M.... Franco B. (1999)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1040 HGNC: 1800 AceView: CDS1 Ensembl:ENSG00000163624 euGenes: HUgn1040
    ECgene: CDS1 Kegg: 1040 H-InvDB: CDS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDS1 gene:
    Search GeneIP for patents involving CDS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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