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CDRT15L2 Gene

protein-coding   GIFtS: 32
GCID: GC17P021896

CMT1A Duplicated Region Transcript 15-Like 2

  Search for CDRT15L2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CMT1A Duplicated Region Transcript 15-Like 21 2
CMT1A Duplicated Region Transcript 15 Protein-Like Protein2

External Ids:    HGNC: 340751   Entrez Gene: 2562232   Ensembl: ENSG000002148197   UniProtKB: A8MXV63   

Export aliases for CDRT15L2 gene to outside databases

Previous GC identifers: GC17P020424 GC17P020481 GC17P019685 GC17P020485 GC17P020726 GC17P021208 GC17P021467


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDRT15L2 Gene:
CDRT15L2 (CMT1A duplicated region transcript 15-like 2) is a protein-coding gene. An important paralog of this gene is CDRT15.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDRT15L2 gene promoter:
         AhR   CREB   SRF   PPAR-gamma1   AML1a   deltaCREB   SRF (504 AA)   PPAR-gamma2   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDRT15L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

CDRT15L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDRT15L2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P021896:  view genomic region     (about GC identifiers)

Start:
20,483,037 bp from pter      End:
20,484,224 bp from pter
Size:
1,188 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: CD15L_HUMAN, A8MXV6 (See protein sequence)
Recommended Name: CMT1A duplicated region transcript 15 protein-like protein  
Size: 281 amino acids; 30100 Da

Explore the universe of human proteins at neXtProt for CDRT15L2: NX_A8MXV6

Explore proteomics data for CDRT15L2 at MOPED


See CDRT15L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001177719.1  
ENSEMBL proteins: 
 ENSP00000382000  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: A8MXV6


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CD15L_HUMAN, A8MXV6: Membrane; Single-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion2
cytosol1
endoplasmic reticulum1
nucleus1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane ----

Find genes that share ontologies with CDRT15L2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDRT15L2
Interactions:

    Search GeneGlobe Interaction Network for CDRT15L2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for CDRT15L2 (CD15L)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CDRT15L2 gene: 
NM_001190790.1  

Unigene Cluster for CDRT15L2:

CMT1A duplicated region transcript 15-like 2
Hs.131916  [show with all ESTs]
Unigene Representative Sequence: NM_001190790
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000399044(uc021tsn.1)
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2 DOTS entries:

DT.120939512  DT.120969953 

5 AceView cDNA sequences:

BX114754 AA446206 AI016778 AA926735 AA446207 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CDRT15L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CDRT15L2 Expression
About this image

CDRT15L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CDRT15L2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.131916
    Custom PCR Arrays for CDRT15L2
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for CDRT15L2 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia LOC4550561 CMT1A duplicated region transcript 15 protein-like more 97.51(n)
95.02(a)
  455056  XM_511823.4  XP_511823.3 


ENSEMBL Gene Tree for CDRT15L2 (if available)
TreeFam Gene Tree for CDRT15L2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CDRT15L2 gene
CDRT152  

Find genes that share paralogs with CDRT15L2           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for CDRT15L2 (see all 12)
PGOHUM00000239358 PGOHUM00000237225 PGOHUM00000237231 PGOHUM00000239119 PGOHUM00000240339


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CDRT15L2 (see all 40)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs768631941,2
C,F--20481088(+) CCTGTA/TCCTGT 1 -- us2k12Minor allele frequency- T:0.11WA 120
rs2001319231,2
--20481194(+) TGGAC-/TTTTGG 1 -- us2k10--------
rs1896064841,2
--20481214(+) GGAATG/TAGTTA 1 -- us2k10--------
rs1496084471,2
C--20481562(+) TCCTGA/GGGCCT 1 -- us2k10--------
rs1833352081,2
--20481570(+) CCTTCA/GCAGCC 1 -- us2k10--------
rs1444147331,2
--20481811(+) GGCAGA/GCCCCT 1 -- us2k10--------
rs1875703701,2
--20481831(+) GCAACA/GTGGGA 1 -- us2k10--------
rs1396361421,2
--20482564(+) AGGTGC/TACCTC 1 -- us2k10--------
rs2008466541,2
C--20482567(+) TGCACA/CTCCGG 1 -- us2k10--------
rs1915983381,2
--20482829(+) GTGTAC/TGGGTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CDRT15L2 (20483037 - 20484224 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CDRT15L2 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2715742CNV Deletion23290073
dgv3104n71CNV Loss21882294
nsv520772CNV Loss19592680
nsv510703CNV Loss20534489
nsv457705CNV Loss19166990
dgv3102n71CNV Loss21882294
nsv833399CNV Loss17160897
nsv521025CNV Gain19592680
esv2751619CNV Gain17911159
nsv907875CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for CDRT15L2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CDRT15L2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 256223 HGNC: 34075 AceView: LOC256223 Ensembl:ENSG00000214819 euGenes: HUgn256223
ECgene: CDRT15L2 H-InvDB: CDRT15L2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CDRT15L2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CDRT15L2 gene:
Search GeneIP for patents involving CDRT15L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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