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Aliases for CDRT15 Gene

Aliases for CDRT15 Gene

  • CMT1A Duplicated Region Transcript 15 2 3 5

External Ids for CDRT15 Gene

Previous GeneCards Identifiers for CDRT15 Gene

  • GC17U990296
  • GC17M014083

Summaries for CDRT15 Gene

GeneCards Summary for CDRT15 Gene

CDRT15 (CMT1A Duplicated Region Transcript 15) is a Protein Coding gene. An important paralog of this gene is CDRT15L2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDRT15 Gene

Genomics for CDRT15 Gene

Regulatory Elements for CDRT15 Gene

Enhancers for CDRT15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDRT15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDRT15 Gene

Chromosome:
17
Start:
14,235,673 bp from pter
End:
14,236,862 bp from pter
Size:
1,190 bases
Orientation:
Minus strand

Genomic View for CDRT15 Gene

Genes around CDRT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDRT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDRT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDRT15 Gene

Proteins for CDRT15 Gene

  • Protein details for CDRT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T59-CDRTF_HUMAN
    Recommended name:
    CMT1A duplicated region transcript 15 protein
    Protein Accession:
    Q96T59
    Secondary Accessions:
    • B2RUU5

    Protein attributes for CDRT15 Gene

    Size:
    188 amino acids
    Molecular mass:
    20651 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDRT15 Gene

Proteomics data for CDRT15 Gene at MOPED

Post-translational modifications for CDRT15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDRT15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDRT15 Gene

Domains & Families for CDRT15 Gene

Protein Domains for CDRT15 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CDRT15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDRT15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDRT15 Gene

Function for CDRT15 Gene

Phenotypes for CDRT15 Gene

GenomeRNAi human phenotypes for CDRT15:
genes like me logo Genes that share phenotypes with CDRT15: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDRT15 Gene

Localization for CDRT15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDRT15 Gene COMPARTMENTS Subcellular localization image for CDRT15 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDRT15 Gene

Pathways & Interactions for CDRT15 Gene

SuperPathways for CDRT15 Gene

No Data Available

Interacting Proteins for CDRT15 Gene

Selected Interacting proteins: Q96T59-CDRTF_HUMAN for CDRT15 Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for CDRT15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDRT15 Gene

Drugs & Compounds for CDRT15 Gene

No Compound Related Data Available

Transcripts for CDRT15 Gene

mRNA/cDNA for CDRT15 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDRT15 Gene

CMT1A duplicated region transcript 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDRT15 Gene

No ASD Table

Relevant External Links for CDRT15 Gene

GeneLoc Exon Structure for
CDRT15
ECgene alternative splicing isoforms for
CDRT15

Expression for CDRT15 Gene

mRNA expression in normal human tissues for CDRT15 Gene

mRNA differential expression in normal tissues according to GTEx for CDRT15 Gene

This gene is overexpressed in Testis (x33.5).

Protein differential expression in normal tissues from HIPED for CDRT15 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDRT15 Gene



SOURCE GeneReport for Unigene cluster for CDRT15 Gene Hs.735172

mRNA Expression by UniProt/SwissProt for CDRT15 Gene

Q96T59-CDRTF_HUMAN
Tissue specificity: Expressed in fetal heart, kidney, liver, lung and spleen.
genes like me logo Genes that share expression patterns with CDRT15: view

Protein tissue co-expression partners for CDRT15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDRT15 Gene

Orthologs for CDRT15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CDRT15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDRT15 35
  • 97.34 (n)
  • 95.21 (a)
CDRT15 36
  • 95 (a)
OneToOne
Species with no ortholog for CDRT15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDRT15 Gene

ENSEMBL:
Gene Tree for CDRT15 (if available)
TreeFam:
Gene Tree for CDRT15 (if available)

Paralogs for CDRT15 Gene

Paralogs for CDRT15 Gene

genes like me logo Genes that share paralogs with CDRT15: view

Variants for CDRT15 Gene

Sequence variations from dbSNP and Humsavar for CDRT15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17679866 - 14,236,763(+) ATCGT(C/T)GGAAA reference, missense
rs2529907 -- 14,238,342(-) TTTCC(A/G)GGTGG upstream-variant-2KB
rs2529908 -- 14,238,162(-) ttatc(A/G)acagt upstream-variant-2KB
rs4791563 -- 14,236,248(+) TTCAG(C/T)TCCAG intron-variant
rs4791564 -- 14,236,457(+) CCAGC(A/C)TCAGT intron-variant

Variation tolerance for CDRT15 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CDRT15 Gene

Disorders for CDRT15 Gene

Relevant External Links for CDRT15

Genetic Association Database (GAD)
CDRT15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDRT15

No disorders were found for CDRT15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDRT15 Gene

Publications for CDRT15 Gene

  1. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K. … Birren B. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDRT15 Gene

Sources for CDRT15 Gene

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