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Aliases for CDRT15 Gene

Aliases for CDRT15 Gene

  • CMT1A Duplicated Region Transcript 15 2 3 5

External Ids for CDRT15 Gene

Previous GeneCards Identifiers for CDRT15 Gene

  • GC17U990296
  • GC17M014083

Summaries for CDRT15 Gene

GeneCards Summary for CDRT15 Gene

CDRT15 (CMT1A Duplicated Region Transcript 15) is a Protein Coding gene. An important paralog of this gene is CDRT15L2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDRT15 Gene

Genomics for CDRT15 Gene

Regulatory Elements for CDRT15 Gene

Enhancers for CDRT15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F014196 1.4 FANTOM5 Ensembl ENCODE 17.8 +36.6 36594 8.4 CTCF HDAC1 KLF1 ESRRA ZNF133 KLF17 RAD21 ZNF121 ZFHX2 GATA3 CDRT15 COX10 CDRT15P1 ENSG00000231595 HS3ST3B1 ENSG00000252305
GH17F014068 1.1 ENCODE 16.4 +166.8 166823 2.9 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KLF13 CDRT15P1 CDRT15 COX10-AS1 ENSG00000252305
GH17F014205 1 Ensembl ENCODE 17.5 +30.7 30668 1.2 PKNOX1 SIN3A RAD21 YY1 GATA3 CTBP1 RCOR1 FOSL2 FOS TCF7L2 CDRT15 COX10-AS1 ENSG00000231595 ENSG00000252305
GH17F014014 0.4 Ensembl 30.9 +221.6 221632 1.1 HLF TCF7 CDRT15P1 CDRT15 GC17P014025 ENSG00000266744
GH17F014316 1.1 Ensembl ENCODE 10.5 -80.7 -80739 3.2 MLX ARID4B FEZF1 RAD21 DNMT3B RARA CREM MIXL1 EGR2 THAP11 ENSG00000231595 CDRT15 ENSG00000266378 MGC12916
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDRT15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDRT15 Gene

Chromosome:
17
Start:
14,235,673 bp from pter
End:
14,236,862 bp from pter
Size:
1,190 bases
Orientation:
Minus strand

Genomic View for CDRT15 Gene

Genes around CDRT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDRT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDRT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDRT15 Gene

Proteins for CDRT15 Gene

  • Protein details for CDRT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T59-CDRTF_HUMAN
    Recommended name:
    CMT1A duplicated region transcript 15 protein
    Protein Accession:
    Q96T59
    Secondary Accessions:
    • B2RUU5

    Protein attributes for CDRT15 Gene

    Size:
    188 amino acids
    Molecular mass:
    20651 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDRT15 Gene

Post-translational modifications for CDRT15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDRT15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDRT15 Gene

Domains & Families for CDRT15 Gene

Protein Domains for CDRT15 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CDRT15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDRT15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDRT15 Gene

Function for CDRT15 Gene

Phenotypes for CDRT15 Gene

genes like me logo Genes that share phenotypes with CDRT15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDRT15 Gene

Localization for CDRT15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDRT15 gene
Compartment Confidence
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDRT15 Gene

Pathways & Interactions for CDRT15 Gene

SuperPathways for CDRT15 Gene

No Data Available

Interacting Proteins for CDRT15 Gene

Gene Ontology (GO) - Biological Process for CDRT15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDRT15 Gene

Transcripts for CDRT15 Gene

mRNA/cDNA for CDRT15 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDRT15 Gene

CMT1A duplicated region transcript 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDRT15 Gene

No ASD Table

Relevant External Links for CDRT15 Gene

GeneLoc Exon Structure for
CDRT15
ECgene alternative splicing isoforms for
CDRT15

Expression for CDRT15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDRT15 Gene

mRNA differential expression in normal tissues according to GTEx for CDRT15 Gene

This gene is overexpressed in Testis (x33.5).

Protein differential expression in normal tissues from HIPED for CDRT15 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDRT15 Gene



Protein tissue co-expression partners for CDRT15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDRT15 Gene:

CDRT15

SOURCE GeneReport for Unigene cluster for CDRT15 Gene:

Hs.735172

mRNA Expression by UniProt/SwissProt for CDRT15 Gene:

Q96T59-CDRTF_HUMAN
Tissue specificity: Expressed in fetal heart, kidney, liver, lung and spleen.
genes like me logo Genes that share expression patterns with CDRT15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDRT15 Gene

Orthologs for CDRT15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CDRT15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDRT15 34 35
  • 97.34 (n)
Species where no ortholog for CDRT15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDRT15 Gene

ENSEMBL:
Gene Tree for CDRT15 (if available)
TreeFam:
Gene Tree for CDRT15 (if available)

Paralogs for CDRT15 Gene

Paralogs for CDRT15 Gene

Pseudogenes.org Pseudogenes for CDRT15 Gene

genes like me logo Genes that share paralogs with CDRT15: view

Variants for CDRT15 Gene

Sequence variations from dbSNP and Humsavar for CDRT15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111982138 -- 14,235,417(+) TGCCA(A/G)ATCCT downstream-variant-500B
rs113074129 -- 14,236,159(+) CCGTG(C/T)CCAGG intron-variant
rs11650811 -- 14,236,571(+) CCTCA(C/T)CAAGT splice-donor-variant
rs11651890 -- 14,236,764(+) TCGTC(A/G)GAAAA reference, stop-gained
rs11867613 -- 14,235,983(+) TTCCC(A/G)GCCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDRT15 Gene

Variant ID Type Subtype PubMed ID
nsv960416 CNV duplication 23825009
nsv574377 CNV gain 21841781
nsv1150083 CNV duplication 26484159
nsv1056267 CNV gain 25217958
esv3640021 CNV gain 21293372
esv3640020 CNV loss 21293372

Variation tolerance for CDRT15 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDRT15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDRT15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDRT15 Gene

Disorders for CDRT15 Gene

Relevant External Links for CDRT15

Genetic Association Database (GAD)
CDRT15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDRT15

No disorders were found for CDRT15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDRT15 Gene

Publications for CDRT15 Gene

  1. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K. … Birren B. (Genome Res. 2001) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CDRT15 Gene

Sources for CDRT15 Gene

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