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Aliases for CDR2L Gene

Aliases for CDR2L Gene

  • Cerebellar Degeneration Related Protein 2 Like 2 3 5
  • Cerebellar Degeneration-Related Protein 2-Like 2 3
  • Paraneoplastic 62 KDa Antigen 3 4
  • Paraneoplastic Antigen 2 3
  • HUMPPA 3 4

External Ids for CDR2L Gene

Previous GeneCards Identifiers for CDR2L Gene

  • GC17P070496
  • GC17P072983
  • GC17P068394

Summaries for CDR2L Gene

GeneCards Summary for CDR2L Gene

CDR2L (Cerebellar Degeneration Related Protein 2 Like) is a Protein Coding gene. Diseases associated with CDR2L include Cerebellar Degeneration. An important paralog of this gene is CDR2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR2L Gene

Genomics for CDR2L Gene

Regulatory Elements for CDR2L Gene

Enhancers for CDR2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075085 1.7 FANTOM5 Ensembl ENCODE 13.5 +103.9 103864 11.9 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 ENSG00000264829 MGC16275 SLC16A5 CDR2L ENSG00000267342 MIF4GD NAT9 MRPS7 MRPL58 MYO15B
GH17F075010 1.5 FANTOM5 ENCODE 14.9 +24.6 24571 3.7 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UNK HID1 ENSG00000267801 ENSG00000266980 ENSG00000264829 NUP85 KCTD2 CDR2L NT5C HID1-AS1
GH17F074511 1.8 FANTOM5 Ensembl ENCODE 10.2 -474.0 -474029 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 CBX5 ZNF416 NUP85 NAT9 NT5C CD300E RN7SL573P LOC100130520 ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935
GH17F075455 1.5 FANTOM5 ENCODE 10.2 +470.6 470611 6.4 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 CDK3 UNK LLGL2 CDR2L TEN1 ENSG00000267801 GRB2 NUP85 MIR6785 TMEM94
GH17F075180 1.1 ENCODE 10.5 +195.0 195018 3.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS NUP85 ATP5H SUMO2 NT5C ENSG00000267342 MIF4GD KCTD2 CDR2L TRIM65 HN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDR2L on UCSC Golden Path with GeneCards custom track

Promoters for CDR2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353172 368 2001 ATF1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 YY1 FOS ZNF263 SP3

Genomic Location for CDR2L Gene

74,987,632 bp from pter
75,005,800 bp from pter
18,169 bases
Plus strand

Genomic View for CDR2L Gene

Genes around CDR2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR2L Gene

Proteins for CDR2L Gene

  • Protein details for CDR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cerebellar degeneration-related protein 2-like
    Protein Accession:
    Secondary Accessions:
    • B4DFA7
    • Q15175

    Protein attributes for CDR2L Gene

    465 amino acids
    Molecular mass:
    53010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA91850.1; Type=Frameshift; Positions=10, 184, 268, 345; Evidence={ECO:0000305}; Sequence=AAH47534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDR2L Gene

Post-translational modifications for CDR2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR2L Gene

Domains & Families for CDR2L Gene

Protein Domains for CDR2L Gene


Suggested Antigen Peptide Sequences for CDR2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDR2 family.
  • Belongs to the CDR2 family.
genes like me logo Genes that share domains with CDR2L: view

No data available for Gene Families for CDR2L Gene

Function for CDR2L Gene

Gene Ontology (GO) - Molecular Function for CDR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with CDR2L: view
genes like me logo Genes that share phenotypes with CDR2L: view

Animal Model Products

miRNA for CDR2L Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDR2L Gene

Localization for CDR2L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDR2L gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR2L Gene

Pathways & Interactions for CDR2L Gene

SuperPathways for CDR2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDR2L Gene


No data available for Pathways by source and SIGNOR curated interactions for CDR2L Gene

Transcripts for CDR2L Gene

mRNA/cDNA for CDR2L Gene

Unigene Clusters for CDR2L Gene

Cerebellar degeneration-related protein 2-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDR2L Gene

No ASD Table

Relevant External Links for CDR2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDR2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDR2L Gene

mRNA differential expression in normal tissues according to GTEx for CDR2L Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for CDR2L Gene

This gene is overexpressed in Plasma (39.2) and Heart (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDR2L Gene

Protein tissue co-expression partners for CDR2L Gene

NURSA nuclear receptor signaling pathways regulating expression of CDR2L Gene:


SOURCE GeneReport for Unigene cluster for CDR2L Gene:

genes like me logo Genes that share expression patterns with CDR2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDR2L Gene

Orthologs for CDR2L Gene

This gene was present in the common ancestor of animals.

Orthologs for CDR2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDR2L 34 35
  • 99.5 (n)
(Canis familiaris)
Mammalia CDR2L 34 35
  • 91.54 (n)
(Bos Taurus)
Mammalia CDR2L 34 35
  • 91.38 (n)
(Rattus norvegicus)
Mammalia Cdr2l 34
  • 88.6 (n)
(Mus musculus)
Mammalia Cdr2l 34 16 35
  • 88.24 (n)
(Ornithorhynchus anatinus)
Mammalia CDR2L 35
  • 75 (a)
(Monodelphis domestica)
Mammalia CDR2L 35
  • 72 (a)
(Gallus gallus)
Aves CDR2L 34 35
  • 76.39 (n)
(Anolis carolinensis)
Reptilia CDR2L 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdr2l 34
  • 70.66 (n)
(Danio rerio)
Actinopterygii cdr2l 34 35
  • 67.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cen 35
  • 13 (a)
Species where no ortholog for CDR2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDR2L Gene

Gene Tree for CDR2L (if available)
Gene Tree for CDR2L (if available)

Paralogs for CDR2L Gene

Paralogs for CDR2L Gene

(1) SIMAP similar genes for CDR2L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDR2L: view

Variants for CDR2L Gene

Sequence variations from dbSNP and Humsavar for CDR2L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10852758 -- 74,985,680(+) caaca(A/G)CTTAC upstream-variant-2KB
rs11077769 -- 74,991,703(+) CAGAG(C/T)GAGAC intron-variant
rs11077770 -- 74,991,728(+) AGAAA(A/G)AAAGA intron-variant
rs111242415 -- 74,990,430(+) AGGAC(A/T)TAATC intron-variant
rs111485617 -- 75,001,192(+) TCATG(C/T)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDR2L Gene

Variant ID Type Subtype PubMed ID
nsv833540 CNV loss 17160897
nsv1056788 CNV gain 25217958

Variation tolerance for CDR2L Gene

Gene Damage Index Score: 1.98; 36.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDR2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDR2L Gene

Disorders for CDR2L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDR2L Gene - From: GeneCards

Disorder Aliases PubMed IDs
cerebellar degeneration
- elite association - COSMIC cancer census association via MalaCards
Search CDR2L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDR2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR2L Gene

Publications for CDR2L Gene

  1. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K. … Roepman R. (Nat Commun 2016) 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for CDR2L Gene

Sources for CDR2L Gene

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