CDR2L Gene
protein-coding GIFtS: 41
GCID: GC17P072983
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|
cerebellar degeneration-related protein 2-like
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Aliases
for CDR2L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cerebellar Degeneration-Related Protein 2-Like1 2 | | HUMPPA1 2 3 | | Paraneoplastic 62 KDa Antigen2 3 | | Paraneoplastic Antigen2 |
Export aliases for CDR2L gene to outside databasesPrevious GC identifers: GC17P070496 GC17P068394 |
Summaries
for CDR2L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CDR2L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDR2L gene promoter:
Pbx1a Tal-1beta LCR-F1 AREB6 MEF-2A c-Rel CP2 Sox9 aMEF-2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDR2L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDR2L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1CDR2L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P072983: view genomic region
(about GC identifiers)
Start:
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72,983,727 bp from pter |
End:
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73,001,895 bp from pter |
Size:
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18,169 bases |
Orientation:
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plus strand |
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Proteins
for CDR2L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDR2L_HUMAN, Q86X02 (See
protein sequence)Recommended Name: Cerebellar degeneration-related protein 2-like Size: 465 amino acids; 53010 Da
Sequence caution: Sequence=AAA91850.1; Type=Frameshift; Positions=10, 184, 268, 345; Sequence=AAH47534.1;Type=Erroneous initiation;
Secondary accessions: B4DFA7 Q15175Explore the universe of human proteins at neXtProt for CDR2L: NX_Q86X02
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86X02
CDR2L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055418.2
ENSEMBL proteins: ENSP00000336587
Human Recombinant Protein Products for CDR2L:
CDR2L Antibody Products:
Assay Products for CDR2L: |
Protein
Domains /
Families
for CDR2L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDR2L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86X02ProtoNet protein and cluster: Q86X02 UniProtKB/Swiss-Prot: CDR2L_HUMAN, Q86X02Similarity: Belongs to the CDR2 family |
Function
for CDR2L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CDR2L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2L |
|
Pathways & Interactions
for CDR2L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDR2L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for CDR2L (Q86X023 ENSP000003365874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CDR2L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDR2L
Search CenterWatch for drugs/clinical trials and news about CDR2L
|
Transcripts
for CDR2L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDR2L gene: NM_014603.2 Unigene Cluster for CDR2L: Cerebellar degeneration-related protein 2-like Hs.78358 [show with all ESTs]Unigene Representative Sequence: NM_0146031 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000337231(uc002jml.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDR2L (NM_014603) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDR2L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2L |
Additional cDNA sequence: AK294006.1 BC013105.2 BC047534.1 CR749715.1 L02867.1 3 DOTS entries: DT.456306 DT.91740462 DT.97843263 24/90 AceView cDNA sequences (see all 90): BU685035 BC047534 BF939923 AI682299 BQ007652 NM_014603 CR598377 BQ219786 BM723075 BQ009482 BQ671973 AW673179 BG032168 CF125249 AW239343 BM740703 AI028681 AI741481 R37688 BQ002019 AA897672 CA428540 BM728314 BU622433
GeneLoc Exon Structure
|
Expression
for CDR2L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDR2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTATTTAT
About this image
See CDR2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDR2L
SOURCE GeneReport for Unigene cluster: Hs.78358
SABiosciences Custom PCR Arrays for CDR2L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDR2L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDR2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDR2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDR2L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2L |
Orthologs
for CDR2L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDR2L gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDR2L1 |
cerebellar degeneration-related protein 2-like |
76.39(n)
75.81(a) |
|
428685 XM_426243.3 XP_426243.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CDR2L6 |
-- |
74(a) |
1 ↔ 1 |
2(114967528-114975688) |
zebrafish
(Danio rerio) |
Actinopterygii |
cdr2l1 |
cerebellar degeneration-related protein 2-like |
67.65(n)
63.04(a) |
|
336227 NM_205564.1 NP_991127.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cen6 |
Centrocortin |
13(a) |
1 → many |
2L(20678921-20681844) |
ENSEMBL Gene Tree for CDR2L (if available)
TreeFam Gene Tree for CDR2L (if available) |
Paralogs
for CDR2L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDR2L gene
- CDR22
1 SIMAP similar gene for CDR2L using alignment to 1 protein entry: CDR2L_HUMAN:CDR2
CDR2L for paralogs About GeneDecksing
|
Genomic Variants
for CDR2L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDR2L (72983727 - 73001895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDR2L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDR2L |
|
Disorders
/ Diseases
for CDR2L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDR2L for disorders About GeneDecksing
1  disease for CDR2L: About MalaCardscerebellar degeneration
Export disorders for CDR2L gene to outside databases
|
Publications
for CDR2L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDR2L gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDR2L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for CDR2L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDR2L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDR2L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDR2L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDR2L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDR2L gene:
Search GeneIP for patents involving CDR2L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDR2L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | CDR2L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2L |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CDR2L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2L |
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