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Aliases for CDR2L Gene

Aliases for CDR2L Gene

  • Cerebellar Degeneration-Related Protein 2-Like 2 3
  • Paraneoplastic 62 KDa Antigen 3 4
  • Paraneoplastic Antigen 2 3
  • HUMPPA 3 4

External Ids for CDR2L Gene

Previous GeneCards Identifiers for CDR2L Gene

  • GC17P070496
  • GC17P072983
  • GC17P068394

Summaries for CDR2L Gene

GeneCards Summary for CDR2L Gene

CDR2L (Cerebellar Degeneration-Related Protein 2-Like) is a Protein Coding gene. Diseases associated with CDR2L include cerebellar degeneration. An important paralog of this gene is CDR2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR2L Gene

Genomics for CDR2L Gene

Regulatory Elements for CDR2L Gene

Genomic Location for CDR2L Gene

74,987,632 bp from pter
75,005,800 bp from pter
18,169 bases
Plus strand

Genomic View for CDR2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR2L Gene

Proteins for CDR2L Gene

  • Protein details for CDR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cerebellar degeneration-related protein 2-like
    Protein Accession:
    Secondary Accessions:
    • B4DFA7
    • Q15175

    Protein attributes for CDR2L Gene

    465 amino acids
    Molecular mass:
    53010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA91850.1; Type=Frameshift; Positions=10, 184, 268, 345; Evidence={ECO:0000305}; Sequence=AAH47534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDR2L Gene

Proteomics data for CDR2L Gene at MOPED

Post-translational modifications for CDR2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR2L Gene

Domains & Families for CDR2L Gene

Protein Domains for CDR2L Gene


Suggested Antigen Peptide Sequences for CDR2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDR2 family.
  • Belongs to the CDR2 family.
genes like me logo Genes that share domains with CDR2L: view

No data available for Gene Families for CDR2L Gene

Function for CDR2L Gene

genes like me logo Genes that share phenotypes with CDR2L: view

Animal Model Products

miRNA for CDR2L Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDR2L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CDR2L Gene

Localization for CDR2L Gene

Subcellular locations from

Jensen Localization Image for CDR2L Gene COMPARTMENTS Subcellular localization image for CDR2L gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR2L Gene

Pathways & Interactions for CDR2L Gene

SuperPathways for CDR2L Gene

No Data Available

Interacting Proteins for CDR2L Gene

Gene Ontology (GO) - Biological Process for CDR2L Gene


No data available for Pathways by source and SIGNOR curated interactions for CDR2L Gene

Drugs & Compounds for CDR2L Gene

No Compound Related Data Available

Transcripts for CDR2L Gene

mRNA/cDNA for CDR2L Gene

Unigene Clusters for CDR2L Gene

Cerebellar degeneration-related protein 2-like:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDR2L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDR2L Gene

No ASD Table

Relevant External Links for CDR2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDR2L Gene

mRNA expression in normal human tissues for CDR2L Gene

mRNA differential expression in normal tissues according to GTEx for CDR2L Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for CDR2L Gene

This gene is overexpressed in Plasma (39.2) and Heart (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDR2L Gene

SOURCE GeneReport for Unigene cluster for CDR2L Gene Hs.78358

genes like me logo Genes that share expression patterns with CDR2L: view

Protein tissue co-expression partners for CDR2L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDR2L Gene

Orthologs for CDR2L Gene

This gene was present in the common ancestor of animals.

Orthologs for CDR2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDR2L 35
  • 91.38 (n)
  • 94.61 (a)
CDR2L 36
  • 93 (a)
(Canis familiaris)
Mammalia CDR2L 35
  • 91.54 (n)
  • 95.91 (a)
CDR2L 36
  • 96 (a)
(Mus musculus)
Mammalia Cdr2l 35
  • 88.24 (n)
  • 93.33 (a)
Cdr2l 16
Cdr2l 36
  • 93 (a)
(Pan troglodytes)
Mammalia CDR2L 35
  • 99.5 (n)
  • 99.57 (a)
CDR2L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdr2l 35
  • 88.6 (n)
  • 94.19 (a)
(Monodelphis domestica)
Mammalia CDR2L 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia CDR2L 36
  • 75 (a)
(Gallus gallus)
Aves CDR2L 35
  • 76.39 (n)
  • 75.81 (a)
CDR2L 36
  • 76 (a)
(Anolis carolinensis)
Reptilia CDR2L 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdr2l 35
  • 70.66 (n)
  • 69.68 (a)
(Danio rerio)
Actinopterygii cdr2l 35
  • 67.57 (n)
  • 63.04 (a)
cdr2l 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cen 36
  • 13 (a)
Species with no ortholog for CDR2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDR2L Gene

Gene Tree for CDR2L (if available)
Gene Tree for CDR2L (if available)

Paralogs for CDR2L Gene

Paralogs for CDR2L Gene

(1) SIMAP similar genes for CDR2L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDR2L: view

Variants for CDR2L Gene

Sequence variations from dbSNP and Humsavar for CDR2L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1873598 -- 74,996,951(-) AACTT(C/T)TTGGC intron-variant
rs2385070 -- 75,003,412(+) GCAGA(A/G)CCTGG frameshift-variant, reference
rs2891669 -- 75,003,414(+) CAGAG(C/G)CTGGA reference, frameshift-variant
rs3744201 -- 75,005,132(-) AACAC(A/G)ATGCA utr-variant-3-prime
rs3744202 -- 75,005,095(-) GTGAA(A/G/T)GGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDR2L Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
dgv3255n71 CNV Loss 21882294
nsv908753 CNV Loss 21882294
nsv908755 CNV Loss 21882294

Variation tolerance for CDR2L Gene

Gene Damage Index Score: 1.98; 36.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDR2L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDR2L Gene

Disorders for CDR2L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDR2L Gene - From: GeneCards

Disorder Aliases PubMed IDs
cerebellar degeneration
- elite association
Search CDR2L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDR2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR2L Gene

Publications for CDR2L Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  3. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PMID: 18220336) Cantin G.T. … Yates J.R. III (J. Proteome Res. 2008) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for CDR2L Gene

Sources for CDR2L Gene

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