Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDR2L Gene

Aliases for CDR2L Gene

  • Cerebellar Degeneration Related Protein 2 Like 2 3
  • Cerebellar Degeneration-Related Protein 2-Like 2 5
  • Paraneoplastic 62 KDa Antigen 3 4
  • Paraneoplastic Antigen 2 3
  • HUMPPA 3 4

External Ids for CDR2L Gene

Previous GeneCards Identifiers for CDR2L Gene

  • GC17P070496
  • GC17P072983
  • GC17P068394

Summaries for CDR2L Gene

GeneCards Summary for CDR2L Gene

CDR2L (Cerebellar Degeneration Related Protein 2 Like) is a Protein Coding gene. Diseases associated with CDR2L include cerebellar degeneration. An important paralog of this gene is CDR2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR2L Gene

Genomics for CDR2L Gene

Regulatory Elements for CDR2L Gene

Enhancers for CDR2L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDR2L on UCSC Golden Path with GeneCards custom track

Promoters for CDR2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDR2L on UCSC Golden Path with GeneCards custom track

Genomic Location for CDR2L Gene

Chromosome:
17
Start:
74,987,632 bp from pter
End:
75,005,800 bp from pter
Size:
18,169 bases
Orientation:
Plus strand

Genomic View for CDR2L Gene

Genes around CDR2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR2L Gene

Proteins for CDR2L Gene

  • Protein details for CDR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X02-CDR2L_HUMAN
    Recommended name:
    Cerebellar degeneration-related protein 2-like
    Protein Accession:
    Q86X02
    Secondary Accessions:
    • B4DFA7
    • Q15175

    Protein attributes for CDR2L Gene

    Size:
    465 amino acids
    Molecular mass:
    53010 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA91850.1; Type=Frameshift; Positions=10, 184, 268, 345; Evidence={ECO:0000305}; Sequence=AAH47534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDR2L Gene

Proteomics data for CDR2L Gene at MOPED

Post-translational modifications for CDR2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR2L Gene

Domains & Families for CDR2L Gene

Protein Domains for CDR2L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDR2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86X02

UniProtKB/Swiss-Prot:

CDR2L_HUMAN :
  • Belongs to the CDR2 family.
Family:
  • Belongs to the CDR2 family.
genes like me logo Genes that share domains with CDR2L: view

No data available for Gene Families for CDR2L Gene

Function for CDR2L Gene

genes like me logo Genes that share phenotypes with CDR2L: view

Animal Model Products

miRNA for CDR2L Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDR2L Gene

Localization for CDR2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDR2L Gene COMPARTMENTS Subcellular localization image for CDR2L gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR2L Gene

Pathways & Interactions for CDR2L Gene

SuperPathways for CDR2L Gene

No Data Available

Interacting Proteins for CDR2L Gene

Gene Ontology (GO) - Biological Process for CDR2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDR2L Gene

Drugs & Compounds for CDR2L Gene

No Compound Related Data Available

Transcripts for CDR2L Gene

mRNA/cDNA for CDR2L Gene

Unigene Clusters for CDR2L Gene

Cerebellar degeneration-related protein 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDR2L Gene

No ASD Table

Relevant External Links for CDR2L Gene

GeneLoc Exon Structure for
CDR2L
ECgene alternative splicing isoforms for
CDR2L

Expression for CDR2L Gene

mRNA expression in normal human tissues for CDR2L Gene

mRNA differential expression in normal tissues according to GTEx for CDR2L Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for CDR2L Gene

This gene is overexpressed in Plasma (39.2) and Heart (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CDR2L Gene



SOURCE GeneReport for Unigene cluster for CDR2L Gene Hs.78358

genes like me logo Genes that share expression patterns with CDR2L: view

Protein tissue co-expression partners for CDR2L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDR2L Gene

Orthologs for CDR2L Gene

This gene was present in the common ancestor of animals.

Orthologs for CDR2L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDR2L 35
  • 91.38 (n)
  • 94.61 (a)
CDR2L 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDR2L 35
  • 91.54 (n)
  • 95.91 (a)
CDR2L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdr2l 35
  • 88.24 (n)
  • 93.33 (a)
Cdr2l 16
Cdr2l 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDR2L 35
  • 99.5 (n)
  • 99.57 (a)
CDR2L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdr2l 35
  • 88.6 (n)
  • 94.19 (a)
oppossum
(Monodelphis domestica)
Mammalia CDR2L 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDR2L 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDR2L 35
  • 76.39 (n)
  • 75.81 (a)
CDR2L 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDR2L 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdr2l 35
  • 70.66 (n)
  • 69.68 (a)
zebrafish
(Danio rerio)
Actinopterygii cdr2l 35
  • 67.57 (n)
  • 63.04 (a)
cdr2l 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cen 36
  • 13 (a)
OneToMany
Species with no ortholog for CDR2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDR2L Gene

ENSEMBL:
Gene Tree for CDR2L (if available)
TreeFam:
Gene Tree for CDR2L (if available)

Paralogs for CDR2L Gene

Paralogs for CDR2L Gene

(1) SIMAP similar genes for CDR2L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDR2L: view

Variants for CDR2L Gene

Sequence variations from dbSNP and Humsavar for CDR2L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs36057512 - 75,003,576(+) CAGGA(A/C)GGGGT reference, missense
rs1873598 -- 74,996,951(-) AACTT(C/T)TTGGC intron-variant
rs3744201 -- 75,005,132(-) AACAC(A/G)ATGCA utr-variant-3-prime
rs3744202 -- 75,005,095(-) GTGAA(A/G/T)GGGAG utr-variant-3-prime
rs3744203 -- 75,003,966(-) CTCTG(C/T)TCCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CDR2L Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
dgv3255n71 CNV Loss 21882294
nsv908753 CNV Loss 21882294
nsv908755 CNV Loss 21882294

Variation tolerance for CDR2L Gene

Gene Damage Index Score: 1.98; 36.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDR2L Gene

HapMap Linkage Disequilibrium report
CDR2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDR2L Gene

Disorders for CDR2L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDR2L Gene - From: GeneCards

Disorder Aliases PubMed IDs
cerebellar degeneration
- elite association - COSMIC cancer census association via MalaCards
Search CDR2L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDR2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDR2L
genes like me logo Genes that share disorders with CDR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR2L Gene

Publications for CDR2L Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDR2L Gene

Sources for CDR2L Gene

Content