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Aliases for CDR2 Gene

Aliases for CDR2 Gene

  • Cerebellar Degeneration Related Protein 2 2 3 5
  • Paraneoplastic Cerebellar Degeneration-Associated Antigen 3 4
  • Cerebellar Degeneration-Related Protein 2, 62kDa 2 3
  • Major Yo Paraneoplastic Antigen 3 4
  • Yo Paraneoplastic Antigen 2 3
  • Cerebellar Degeneration-Related Protein (62kD) 2
  • CDR62 3
  • PCD17 4
  • Yo 3

External Ids for CDR2 Gene

Previous GeneCards Identifiers for CDR2 Gene

  • GC16M021758
  • GC16M022365
  • GC16M022323
  • GC16M022264
  • GC16M020602

Summaries for CDR2 Gene

GeneCards Summary for CDR2 Gene

CDR2 (Cerebellar Degeneration Related Protein 2) is a Protein Coding gene. Diseases associated with CDR2 include cerebellar degeneration and paraneoplastic cerebellar degeneration. An important paralog of this gene is CDR2L.

Gene Wiki entry for CDR2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR2 Gene

Genomics for CDR2 Gene

Regulatory Elements for CDR2 Gene

Genomic Location for CDR2 Gene

Chromosome:
16
Start:
22,345,936 bp from pter
End:
22,437,165 bp from pter
Size:
91,230 bases
Orientation:
Minus strand

Genomic View for CDR2 Gene

Genes around CDR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR2 Gene

Proteins for CDR2 Gene

  • Protein details for CDR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01850-CDR2_HUMAN
    Recommended name:
    Cerebellar degeneration-related protein 2
    Protein Accession:
    Q01850
    Secondary Accessions:
    • A8K8A8
    • Q13977

    Protein attributes for CDR2 Gene

    Size:
    454 amino acids
    Molecular mass:
    51855 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA51961.1; Type=Frameshift; Positions=379, 384, 393; Evidence={ECO:0000305}; Sequence=AAB20813.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA02360.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDR2 Gene

Proteomics data for CDR2 Gene at MOPED

Post-translational modifications for CDR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR2 Gene

Antibody Products

No data available for DME Specific Peptides for CDR2 Gene

Domains & Families for CDR2 Gene

Protein Domains for CDR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q01850

UniProtKB/Swiss-Prot:

CDR2_HUMAN :
  • Belongs to the CDR2 family.
Family:
  • Belongs to the CDR2 family.
genes like me logo Genes that share domains with CDR2: view

No data available for Gene Families for CDR2 Gene

Function for CDR2 Gene

Molecular function for CDR2 Gene

GENATLAS Biochemistry:
cerebellar degeneration-related major antigen,62kDa,putative neuronal signal transduction protein,identified using antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder

Gene Ontology (GO) - Molecular Function for CDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CDR2: view
genes like me logo Genes that share phenotypes with CDR2: view

Animal Models for CDR2 Gene

MGI Knock Outs for CDR2:

Animal Model Products

miRNA for CDR2 Gene

miRTarBase miRNAs that target CDR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDR2 Gene

Localization for CDR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDR2 Gene COMPARTMENTS Subcellular localization image for CDR2 gene
Compartment Confidence
nucleus 4
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR2 Gene

Pathways & Interactions for CDR2 Gene

SuperPathways for CDR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDR2 Gene

Drugs & Compounds for CDR2 Gene

No Compound Related Data Available

Transcripts for CDR2 Gene

Unigene Clusters for CDR2 Gene

Cerebellar degeneration-related protein 2, 62kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDR2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - - - -
SP3:
SP4: - -

Relevant External Links for CDR2 Gene

GeneLoc Exon Structure for
CDR2
ECgene alternative splicing isoforms for
CDR2

Expression for CDR2 Gene

mRNA expression in normal human tissues for CDR2 Gene

Protein differential expression in normal tissues from HIPED for CDR2 Gene

This gene is overexpressed in Testis (25.1), Retina (22.6), and Peripheral blood mononuclear cells (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDR2 Gene



SOURCE GeneReport for Unigene cluster for CDR2 Gene Hs.513430

genes like me logo Genes that share expression patterns with CDR2: view

Protein tissue co-expression partners for CDR2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDR2 Gene

Orthologs for CDR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDR2 35
  • 97.79 (n)
  • 96.69 (a)
CDR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDR2 36
  • 90 (a)
OneToOne
CDR2 35
  • 88.47 (n)
  • 91.19 (a)
dog
(Canis familiaris)
Mammalia CDR2 35
  • 89.68 (n)
  • 92.67 (a)
CDR2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdr2 16
Cdr2 35
  • 85.87 (n)
  • 89.18 (a)
Cdr2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDR2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDR2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdr2 35
  • 85.25 (n)
  • 88.27 (a)
chicken
(Gallus gallus)
Aves CDR2 35
  • 69.78 (n)
  • 72.38 (a)
CDR2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDR2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdr2 35
  • 65.9 (n)
  • 64.91 (a)
Str.4745 35
zebrafish
(Danio rerio)
Actinopterygii CDR2 (2 of 2) 36
  • 27 (a)
OneToMany
cdr2a 36
  • 45 (a)
OneToMany
LOC100148175 35
  • 57.81 (n)
  • 50.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cen 36
  • 12 (a)
OneToMany
Species with no ortholog for CDR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDR2 Gene

ENSEMBL:
Gene Tree for CDR2 (if available)
TreeFam:
Gene Tree for CDR2 (if available)

Paralogs for CDR2 Gene

Paralogs for CDR2 Gene

(1) SIMAP similar genes for CDR2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CDR2 Gene

genes like me logo Genes that share paralogs with CDR2: view

Variants for CDR2 Gene

Sequence variations from dbSNP and Humsavar for CDR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4238735 -- 22,349,064(+) TAAAA(A/G)CACTG intron-variant
rs4353471 -- 22,363,734(+) TGGGG(A/G)AAGCA intron-variant
rs4468604 -- 22,365,682(+) TTTCA(A/G)CTCTC intron-variant
rs7195033 -- 22,349,296(+) TACAG(A/C/T)TCCTT reference, synonymous-codon, utr-variant-5-prime
rs8047148 -- 22,363,509(+) TGTAT(A/G)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDR2 Gene

Variant ID Type Subtype PubMed ID
nsv7280 OTHER Inversion 18451855
dgv3n1 OTHER Inversion 15895083
nsv511047 OTHER Inversion 20534489
dgv47n16 OTHER Inversion 17901297
nsv499139 OTHER Inversion 21111241
esv998989 OTHER Inversion 20482838
esv2714070 CNV Deletion 23290073
dgv48n16 CNV Insertion 17901297
nsv1764 CNV Loss 18451855
nsv435668 CNV Deletion 17901297
nsv498860 CNV Loss 21111241
dgv2647n71 CNV Loss 21882294
nsv519813 CNV Gain+Loss 19592680
dgv834e1 CNV Complex 17122850
nsv9404 CNV Gain 18304495

Variation tolerance for CDR2 Gene

Residual Variation Intolerance Score: 9.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDR2 Gene

HapMap Linkage Disequilibrium report
CDR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDR2 Gene

Disorders for CDR2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDR2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDR2

Genetic Association Database (GAD)
CDR2
Human Genome Epidemiology (HuGE) Navigator
CDR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDR2
genes like me logo Genes that share disorders with CDR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR2 Gene

Publications for CDR2 Gene

  1. Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration. (PMID: 2014264) Fathallah-Shaykh H. … Furneaux H.M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
  2. The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells. (PMID: 20383333) O'Donovan K.J. … Darnell R.B. (PLoS ONE 2010) 3 23
  3. Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (PMID: 19581925) Balamurugan K. … Camenisch G. (Oncogene 2009) 3 23
  4. The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. (PMID: 10465786) Okano H.J. … Darnell R.B. (Genes Dev. 1999) 3 23
  5. PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor. (PMID: 9637778) Takanaga H. … Ono Y. (Exp. Cell Res. 1998) 3 23

Products for CDR2 Gene

Sources for CDR2 Gene

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