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Aliases for CDR2 Gene

Aliases for CDR2 Gene

  • Cerebellar Degeneration Related Protein 2 2 3 5
  • Paraneoplastic Cerebellar Degeneration-Associated Antigen 3 4
  • Cerebellar Degeneration-Related Protein 2, 62kDa 2 3
  • Major Yo Paraneoplastic Antigen 3 4
  • Yo Paraneoplastic Antigen 2 3
  • Cerebellar Degeneration-Related Protein (62kD) 2
  • Cerebellar Degeneration-Related Protein 2 3
  • CDR62 3
  • PCD17 4
  • Yo 3

External Ids for CDR2 Gene

Previous GeneCards Identifiers for CDR2 Gene

  • GC16M021758
  • GC16M022365
  • GC16M022323
  • GC16M022264
  • GC16M020602

Summaries for CDR2 Gene

GeneCards Summary for CDR2 Gene

CDR2 (Cerebellar Degeneration Related Protein 2) is a Protein Coding gene. Diseases associated with CDR2 include Cerebellar Degeneration and Paraneoplastic Cerebellar Degeneration. An important paralog of this gene is CDR2L.

Gene Wiki entry for CDR2 Gene

Additional gene information for CDR2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR2 Gene

Genomics for CDR2 Gene

Regulatory Elements for CDR2 Gene

Enhancers for CDR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H022194 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +241.5 241466 2.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B YY1 SMG1P3 SMG1P1 NPIPB3 C16orf52 NPIPB4 SMG1P4 NPIPB5 POLR3E MFSD13B ENSG00000260635
GH16H022296 1.2 ENCODE 13.5 +139.4 139383 3.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZFP41 NPIPB4 SMG1P3 NPIPB3 NPIPB5 SMG1P1 MFSD13B RRN3P1 C16orf52 SMG1P4 ENSG00000260635
GH16H022351 1.2 Ensembl ENCODE 12 +83.8 83828 3.2 FOXA2 ATF1 ARID4B FEZF1 TCF12 ATF7 FOS RUNX3 JUNB REST CDR2 POLR3E PDZD9 ENSG00000260635 GC16M022309
GH16H023408 1.2 FANTOM5 ENCODE 9.9 -971.9 -971850 1.2 ZNF473 ZSCAN4 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZEB1 GATA2 ZNF366 ENSG00000260482 DCTN5 PALB2 SMG1P1 NPIPB5 COG7 ENSG00000260751 ENSG00000260136 CDR2 RN7SKP23
GH16H021819 1.1 ENCODE 10.7 +616.9 616906 1.6 HDGF ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 ZNF207 ZNF548 NPIPB4 NPIPB5 NPIPB3 SMG1P3 ENSG00000260635 SMG1P4 SMG1P1 ENSG00000260905 POLR3E MFSD13B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDR2 on UCSC Golden Path with GeneCards custom track

Promoters for CDR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084460 -235 3201 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF143 ZNF207

Genomic Locations for CDR2 Gene

Genomic Locations for CDR2 Gene
chr16:22,345,936-22,437,165
(GRCh38/hg38)
Size:
91,230 bases
Orientation:
Minus strand
chr16:22,357,257-22,448,486
(GRCh37/hg19)

Genomic View for CDR2 Gene

Genes around CDR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR2 Gene

Proteins for CDR2 Gene

  • Protein details for CDR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01850-CDR2_HUMAN
    Recommended name:
    Cerebellar degeneration-related protein 2
    Protein Accession:
    Q01850
    Secondary Accessions:
    • A8K8A8
    • Q13977

    Protein attributes for CDR2 Gene

    Size:
    454 amino acids
    Molecular mass:
    51855 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA51961.1; Type=Frameshift; Positions=379, 384, 393; Evidence={ECO:0000305}; Sequence=AAB20813.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA02360.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDR2 Gene

Post-translational modifications for CDR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR2 Gene

No data available for DME Specific Peptides for CDR2 Gene

Domains & Families for CDR2 Gene

Gene Families for CDR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q01850

UniProtKB/Swiss-Prot:

CDR2_HUMAN :
  • Belongs to the CDR2 family.
Family:
  • Belongs to the CDR2 family.
genes like me logo Genes that share domains with CDR2: view

Function for CDR2 Gene

Molecular function for CDR2 Gene

GENATLAS Biochemistry:
cerebellar degeneration-related major antigen,62kDa,putative neuronal signal transduction protein,identified using antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder

Phenotypes From GWAS Catalog for CDR2 Gene

Gene Ontology (GO) - Molecular Function for CDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 11988016
genes like me logo Genes that share ontologies with CDR2: view
genes like me logo Genes that share phenotypes with CDR2: view

Animal Models for CDR2 Gene

MGI Knock Outs for CDR2:

Animal Model Products

miRNA for CDR2 Gene

miRTarBase miRNAs that target CDR2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDR2 Gene

Localization for CDR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDR2 gene
Compartment Confidence
nucleus 4
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDR2 Gene

Pathways & Interactions for CDR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDR2 Gene

Drugs & Compounds for CDR2 Gene

No Compound Related Data Available

Transcripts for CDR2 Gene

mRNA/cDNA for CDR2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDR2 Gene

Cerebellar degeneration-related protein 2, 62kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDR2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - - - -
SP3:
SP4: - -

Relevant External Links for CDR2 Gene

GeneLoc Exon Structure for
CDR2
ECgene alternative splicing isoforms for
CDR2

Expression for CDR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDR2 Gene

Protein differential expression in normal tissues from HIPED for CDR2 Gene

This gene is overexpressed in Testis (25.1), Retina (22.6), and Peripheral blood mononuclear cells (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDR2 Gene



Protein tissue co-expression partners for CDR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDR2 Gene:

CDR2

SOURCE GeneReport for Unigene cluster for CDR2 Gene:

Hs.513430

Evidence on tissue expression from TISSUES for CDR2 Gene

  • Nervous system(4.5)
  • Eye(4.2)
  • Liver(4.2)
  • Blood(2.3)
  • Spleen(2.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CDR2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDR2 Gene

Orthologs for CDR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDR2 33 34
  • 97.79 (n)
dog
(Canis familiaris)
Mammalia CDR2 33 34
  • 89.68 (n)
cow
(Bos Taurus)
Mammalia CDR2 33 34
  • 88.47 (n)
mouse
(Mus musculus)
Mammalia Cdr2 33 16 34
  • 85.87 (n)
rat
(Rattus norvegicus)
Mammalia Cdr2 33
  • 85.25 (n)
oppossum
(Monodelphis domestica)
Mammalia CDR2 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDR2 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDR2 33 34
  • 69.78 (n)
lizard
(Anolis carolinensis)
Reptilia CDR2 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdr2 33
  • 65.9 (n)
Str.4745 33
zebrafish
(Danio rerio)
Actinopterygii LOC100148175 33
  • 57.81 (n)
cdr2a 34
  • 45 (a)
OneToMany
CDR2 (2 of 2) 34
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cen 34
  • 12 (a)
OneToMany
Species where no ortholog for CDR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDR2 Gene

ENSEMBL:
Gene Tree for CDR2 (if available)
TreeFam:
Gene Tree for CDR2 (if available)

Paralogs for CDR2 Gene

Paralogs for CDR2 Gene

(1) SIMAP similar genes for CDR2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CDR2 Gene

genes like me logo Genes that share paralogs with CDR2: view

Variants for CDR2 Gene

Sequence variations from dbSNP and Humsavar for CDR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000024422 -- 22,371,646(+) TGGGG(A/G)AAGGA intron-variant
rs1000084435 -- 22,374,421(+) CGGGA(A/C)GCGCC upstream-variant-2KB, utr-variant-5-prime
rs1000161068 -- 22,354,360(+) TCCCT(G/T)CATAG intron-variant
rs1000289175 -- 22,374,586(+) CTTCA(C/G)GCCGC nc-transcript-variant, utr-variant-5-prime
rs1000297932 -- 22,354,685(+) GAGTT(C/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDR2 Gene

Variant ID Type Subtype PubMed ID
nsv9404 CNV gain 18304495
nsv7280 OTHER inversion 18451855
nsv499139 OTHER inversion 21111241
nsv1140248 OTHER inversion 24896259
nsv1077770 OTHER inversion 25765185
esv998989 OTHER inversion 20482838
esv3638204 CNV gain 21293372
esv3368991 OTHER inversion 20981092
esv2758637 CNV gain+loss 17122850
dgv47n16 OTHER inversion 17901297
dgv3n1 OTHER inversion 15895083
dgv2812n100 CNV loss 25217958

Variation tolerance for CDR2 Gene

Residual Variation Intolerance Score: 9.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDR2 Gene

Disorders for CDR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDR2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDR2

Genetic Association Database (GAD)
CDR2
Human Genome Epidemiology (HuGE) Navigator
CDR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDR2
genes like me logo Genes that share disorders with CDR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR2 Gene

Publications for CDR2 Gene

  1. Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration. (PMID: 2014264) Fathallah-Shaykh H … Furneaux HM (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells. (PMID: 20383333) O'Donovan KJ … Darnell RB (PloS one 2010) 3 22 60
  4. Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (PMID: 19581925) Balamurugan K … Camenisch G (Oncogene 2009) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CDR2 Gene

Sources for CDR2 Gene

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