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CDR2 Gene

protein-coding   GIFtS: 55
GCID: GC16M022357

Cerebellar Degeneration-Related Protein 2, 62kDa

(Previous name: cerebellar degeneration-related protein (62kD))
  See CDR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cerebellar Degeneration-Related Protein 2, 62kDa1 2     CDR622
Yo Paraneoplastic Antigen1 2     Yo2
Major Yo Paraneoplastic Antigen2 3     Cerebellar Degeneration-Related Protein 22
Paraneoplastic Cerebellar Degeneration-Associated Antigen2 3     PCD173
Cerebellar Degeneration-Related Protein (62kD)1     

External Ids:    HGNC: 17991   Entrez Gene: 10392   Ensembl: ENSG000001407437   OMIM: 1173405   UniProtKB: Q018503   

Export aliases for CDR2 gene to outside databases

Previous GC identifers: GC16M021758 GC16M022365 GC16M022323 GC16M022264 GC16M020602


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDR2 Gene:
CDR2 (cerebellar degeneration-related protein 2, 62kDa) is a protein-coding gene. Diseases associated with CDR2 include gait apraxia, and paraneoplastic neurologic disorders. An important paralog of this gene is CDR2L.

Gene Wiki entry for CDR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDR2 gene promoter:
         HOXA9   AhR   ISGF-3   LHX3b/Lhx3b   XBP-1   POU3F2   RORalpha2   LHX3a/Lhx3a   Meis-1a   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDR2 promoter sequence
   Search Chromatin IP Primers for CDR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p13.1-p12

CDR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDR2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M022357:  view genomic region     (about GC identifiers)

Start:
22,357,257 bp from pter      End:
22,448,486 bp from pter
Size:
91,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDR2_HUMAN, Q01850 (See protein sequence)
Recommended Name: Cerebellar degeneration-related protein 2  
Size: 454 amino acids; 51855 Da
Sequence caution: Sequence=AAA51961.1; Type=Frameshift; Positions=379, 384, 393; Sequence=AAB20813.1;
Type=Erroneous initiation; Sequence=BAA02360.1; Type=Erroneous initiation;
Secondary accessions: A8K8A8 Q13977

Explore the universe of human proteins at neXtProt for CDR2: NX_Q01850

Explore proteomics data for CDR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001793.1  
    ENSEMBL proteins: 
     ENSP00000268383   ENSP00000457432   ENSP00000455915   ENSP00000457289   ENSP00000457596  
     ENSP00000454706  

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    Novus Biologicals CDR2 Proteins
    Novus Biologicals CDR2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CDR2

     
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    LSBio Antibodies in human, mouse, rat for CDR2

    CDR2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CDR2
    Cloud-Clone Corp. CLIAs for CDR2
    Search eBioscience for ELISAs for CDR2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026079 CDR2

    Graphical View of Domain Structure for InterPro Entry Q01850

    ProtoNet protein and cluster: Q01850

    UniProtKB/Swiss-Prot: CDR2_HUMAN, Q01850
    Similarity: Belongs to the CDR2 family


    Find genes that share domains with CDR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CDR2:
    cerebellar degeneration-related major antigen,62kDa,putative neuronal signal transduction protein,identified using
    antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI11988016
         
    Find genes that share ontologies with CDR2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDR2:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cdr2):
     normal 

    Find genes that share phenotypes with CDR2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDR2

    miRNA
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    miRTarBase miRNAs that target CDR2:
    hsa-mir-375 (MIRT019950)

    Block miRNA regulation of human, mouse, rat CDR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDR2 (see all 12):
    hsa-miR-376b hsa-miR-429 hsa-miR-27a hsa-miR-376a hsa-miR-3692 hsa-miR-646 hsa-miR-200c hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCDR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDR2

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    GenScript: all cDNA clones in your preferred vector: CDR2 (NM_001802)
    Sino Biological Human cDNA Clone for CDR2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus3
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CDR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDR2
    Interactions:

        GeneGlobe Interaction Network for CDR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CDR2 (Q018501, 3 ENSP000002683834) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MORF4L2Q150141, 3EBI-1181367,EBI-399257 I2D: score=3 
    ASS1P009663, ENSP000002530044I2D: score=2 STRING: ENSP00000253004
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    FOLR2P142073, ENSP000002982234I2D: score=1 STRING: ENSP00000298223
    PKN1Q165123, ENSP000003433254I2D: score=3 STRING: ENSP00000343325
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDR2 gene: 
    NM_001802.1  

    Unigene Cluster for CDR2:

    Cerebellar degeneration-related protein 2, 62kDa
    Hs.513430  [show with all ESTs]
    Unigene Representative Sequence: BC017503
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268383(uc002dkn.3) ENST00000564542 ENST00000561630 ENST00000567406
    ENST00000567010 ENST00000563573 ENST00000569045
    miRNA
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    Block miRNA regulation of human, mouse, rat CDR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDR2 (see all 12):
    hsa-miR-376b hsa-miR-429 hsa-miR-27a hsa-miR-376a hsa-miR-3692 hsa-miR-646 hsa-miR-200c hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCDR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDR2
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    Primer
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    OriGene qPCR primer pairs and template standards for CDR2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDR2
      QuantiTect SYBR Green Assays in human, mouse, rat CDR2
      QuantiFast Probe-based Assays in human, mouse, rat CDR2

    Additional mRNA sequence: 

    AK292273.1 BC017503.1 D12981.1 M63256.1 

    7 DOTS entries:

    DT.97842518  DT.75103832  DT.416005  DT.91803187  DT.120658652  DT.92453494  DT.92453499 

    Selected AceView cDNA sequences (see all 278):

    BU952602 AL041649 BQ013390 BM675251 AL041502 CR617156 F09110 AI369418 
    BM853758 AK055742 AA074613 BF001768 AI990995 AA480340 BM980727 AW242907 
    AA043995 BE222026 BF222127 AI700364 BQ637118 AL041501 AW005789 BQ649366 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDR2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                                -                                 
    SP2:        -     -     -     -     -                                 
    SP3:                                                                  
    SP4:                          -     -                                 


    ECgene alternative splicing isoforms for CDR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAACTGGC
    CDR2 Expression
    About this image


    CDR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Globus Pallidus
             Septum   
     
     Testis (Reproductive System)
    CDR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513430
        Custom PCR Arrays for CDR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdr21 , 5 cerebellar degeneration-related 21, 5 85.87(n)1
    89.18(a)1
      7 (65.04 cM)5
    125851  NM_007672.21  NP_031698.21 
     1209570365 
    chicken
    (Gallus gallus)
    Aves CDR21 cerebellar degeneration-related protein 2, 62kDa 69.78(n)
    72.38(a)
      416621  NM_001030642.1  NP_001025813.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDR26
    cerebellar degeneration-related protein 2, 62kDa
    70(a)
    1 ↔ 1
    GL343846.1(11243-21061)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.47452 Transcribed sequence with weak similarity to protein more 76.26(n)    BQ388488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001481751 cerebellar degeneration-related protein 2-like 57.81(n)
    50.96(a)
      100148175  XM_001921397.3  XP_001921432.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cen6
    Centrocortin
    12(a)
    1 → many
    2L(20678921-20681844)


    ENSEMBL Gene Tree for CDR2 (if available)
    TreeFam Gene Tree for CDR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDR2 gene
    CDR2L2  
    1 SIMAP similar gene for CDR2 using alignment to 6 protein entries:     CDR2_HUMAN (see all proteins):
    CDR2L

    Find genes that share paralogs with CDR2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CDR2
    PGOHUM00000235530


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDR2 (see all 520)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007674581,2
    C--22356893(+) ACATT-/AATAGT
    ATAGTTTG
    AATAG
    1 -- ds50010--------
    rs1401167791,2
    --22356929(+) AGTATA/GGTTTC 1 -- ds50010--------
    rs2015568111,2
    --22357016(+) GAAAT-/AGTG  
            
    AAAAT
    1 -- ds50010--------
    rs1421240021,2
    C--22357231(+) TTATAC/TTGAAA 1 -- ds50010--------
    rs1834821281,2
    --22357234(+) TATTGA/GAAGTA 1 -- ds50010--------
    rs1880885381,2
    --22357310(+) TAATCA/GGAACA 1 -- ut310--------
    rs567729321,2
    C--22357373(+) CAGTC-/AGAAGATC 1 -- cds11Minor allele frequency- AGA:0.50CSA 2
    rs2019306631,2
    C--22357378(-) GTATTC/GATCTG 1 -- ut310--------
    rs1463753231,2
    --22357438(+) GGAATC/GGTAAG 1 -- ut310--------
    rs1927048381,2
    --22357542(+) TTGAGA/GAAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDR2 (22357257 - 22448486 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDR2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714070CNV Deletion23290073
    nsv435668CNV Deletion17901297
    dgv48n16CNV Insertion17901297
    nsv1764CNV Loss18451855
    nsv498860CNV Loss21111241
    dgv2647n71CNV Loss21882294
    nsv9404CNV Gain18304495
    nsv519813CNV Gain+Loss19592680
    dgv834e1CNV Complex17122850
    nsv7280OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 117340    OMIM disorders: --

    2 diseases for CDR2:    
    About MalaCards
    gait apraxia    paraneoplastic neurologic disorders

    1 disease from the University of Copenhagen DISEASES database for CDR2:
    Gait apraxia

    Find genes that share disorders with CDR2           About GenesLikeMe

    5 Novoseek inferred disease relationships for CDR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic cerebellar degeneration 97 10 18053582 (2), 10465786 (1), 10500270 (1), 8545049 (1) (see all 9)
    cerebellar degeneration 86.6 5 10465786 (1), 16542365 (1), 19581925 (1), 18053582 (1)
    ovarian cancer 20.1 2 10786675 (1)
    tumors 11.4 23 19581925 (4), 10786675 (3), 10465786 (2), 20383333 (2) (see all 5)
    cancer 8.71 2 10786675 (1)

    Genetic Association Database (GAD): CDR2
    Human Genome Epidemiology (HuGE) Navigator: CDR2 (1 document)

    Export disorders for CDR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDR2 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with CDR2)
        Utopia: connect your pdf to the dynamic
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    1. Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration. (PubMed id 2014264)1, 2, 3 Fathallah-Shaykh H.... Furneaux H.M. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration. (PubMed id 1763903)1, 2 Sakai K....Steinman L. (Ann. Neurol. 1991)
    5. Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration. (PubMed id 2260856)1, 2 Sakai K.... Steinman L. (Ann. Neurol. 1990)
    6. Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (PubMed id 19581925)1, 9 Balamurugan K....Camenisch G. (Oncogene 2009)
    7. The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. (PubMed id 10465786)1, 9 Okano H.J....Darnell R.B. (amp 1999)
    8. PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor. (PubMed id 9637778)1, 9 Takanaga H....Ono Y. (Exp. Cell Res. 1998)
    9. The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells. (PubMed id 20383333)1, 9 O'Donovan K.J....Darnell R.B. (PLoS ONE 2010)
    10. Onconeuronal antigen Cdr2 correlates with HIF prolyl-4-hydroxylase PHD1 and worse prognosis in renal cell carcinoma. (PubMed id 23531419)1 Kaufmann M.R....Camenisch G. (Exp. Mol. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1039 HGNC: 1799 AceView: CDR2 Ensembl:ENSG00000140743 euGenes: HUgn1039
    ECgene: CDR2 H-InvDB: CDR2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDR2 gene:
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    GeneCards and IP:
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