Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDR2 Gene

protein-coding   GIFtS: 54
GCID: GC16M022357

cerebellar degeneration-related protein 2, 62kDa

(Previous name: cerebellar degeneration-related protein (62kD) )
 Explore 16 diseases affiliated with
CDR2 via our new
 Human Malady Compendium 
Biological research products
for CDR2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cerebellar Degeneration-Related Protein 2, 62kDa1 2     Cerebellar Degeneration-Related Protein (62kD)1
CDR621 2     Cerebellar Degeneration-Related Protein 22
Yo1 2     Yo Paraneoplastic Antigen2
Major Yo Paraneoplastic Antigen2 3     PCD173
Paraneoplastic Cerebellar Degeneration-Associated Antigen2 3     

External Ids:    HGNC: 17991   Entrez Gene: 10392   Ensembl: ENSG000001407437   OMIM: 1173405   UniProtKB: Q018503   

Export aliases for CDR2 gene to outside databases

Previous GC identifers: GC16M021758 GC16M022365 GC16M022323 GC16M022264 GC16M020602


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for CDR2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDR2 gene promoter:
         HOXA9   AhR   ISGF-3   LHX3b/Lhx3b   XBP-1   POU3F2   RORalpha2   LHX3a/Lhx3a   Meis-1a   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p13.1-p12

CDR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDR2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M022357:  view genomic region     (about GC identifiers)

Start:
22,357,257 bp from pter      End:
22,448,486 bp from pter
Size:
91,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDR2_HUMAN, Q01850 (See protein sequence)
Recommended Name: Cerebellar degeneration-related protein 2  
Size: 454 amino acids; 51855 Da
Sequence caution: Sequence=AAA51961.1; Type=Frameshift; Positions=379, 384, 393; Sequence=AAB20813.1; Type=Erroneous
initiation; Sequence=BAA02360.1; Type=Erroneous initiation;
Secondary accessions: A8K8A8 Q13977

Explore the universe of human proteins at neXtProt for CDR2: NX_Q01850

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01850

  • CDR2 Protein expression data from MOPED and PaxDb:    About this image 
    CDR2 Protein Expression
    REFSEQ proteins: NP_001793.1  
    ENSEMBL proteins: 
     ENSP00000268383   ENSP00000457432   ENSP00000455915   ENSP00000457289   ENSP00000457596  
     ENSP00000454706  

    Human Recombinant Protein Products for CDR2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CDR2
    OriGene Custom Protein Services for CDR2 
    GenScript Custom Purified and Recombinant Proteins Services for CDR2
    Novus Biologicals CDR2 Proteins
    Novus Biologicals CDR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDR2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005737cytoplasm IEA--

    CDR2 for ontologies           About GeneDecksing



    CDR2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: CDR2
    OriGene Custom Antibody Services for CDR2 
    GenScript Custom Superior Antibodies Services for CDR2
    Novus Biologicals CDR2 Antibodies
    Abcam antibodies for CDR2 
    Uscn Antibodies for CDR2
    ThermoFisher Antibody for CDR2

    Assay Products for CDR2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDR2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDR2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDR2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026079 CDR2

    Graphical View of Domain Structure for InterPro Entry Q01850

    ProtoNet protein and cluster: Q01850

    UniProtKB/Swiss-Prot: CDR2_HUMAN, Q01850
    Similarity: Belongs to the CDR2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for CDR2:
    cerebellar degeneration-related major antigen,62kDa,putative neuronal signal transduction protein,identified using
    antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity ----
    GO:0005515protein binding IPI11988016
         
    CDR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDR2:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cdr2):
     normal 

    CDR2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDR2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CDR2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDR2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CDR2 (see all 12):
    hsa-miR-376b hsa-miR-429 hsa-miR-27a hsa-miR-376a hsa-miR-3692 hsa-miR-646 hsa-miR-200c hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCDR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDR2 (see all 7)
    OriGene shRNA RFP: CDR2
    OriGene siRNA: CDR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDR2
    Sirion Biotech Custom design and validation of potent shRNA sequences against CDR2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDR2
    Sirion Biotech Customized adenovirus for overexpression of CDR2 
    Sirion Biotech Customized adenovirus for potent knockdown of CDR2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDR2 (NM_001802)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDR2
    Search LifeMap BioReagents cell lines for CDR2
    Sirion Biotech Customized stable knockdown cell line services for CDR2 
    Sirion Biotech Customized inducible knockdown cell line services for CDR2
    Sirion Biotech Customized stable overexpressing cell line services for CDR2
    Sirion Biotech Customized inducible overexpressing cell line services for CDR2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for CDR2 (Q018501, 3 ENSP000002683834) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MORF4L2Q150141, 3EBI-1181367,EBI-399257 I2D: score=3 
    ASS1P009663, ENSP000002530044I2D: score=2 STRING: ENSP00000253004
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    FOLR2P142073, ENSP000002982234I2D: score=1 STRING: ENSP00000298223
    PKN1Q165123, ENSP000003433254I2D: score=3 STRING: ENSP00000343325
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDR2
    Search CenterWatch for drugs/clinical trials and news about CDR2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDR2 gene: 
    NM_001802.1  

    Unigene Cluster for CDR2:

    Cerebellar degeneration-related protein 2, 62kDa
    Hs.513430  [show with all ESTs]
    Unigene Representative Sequence: BC017503
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268383(uc002dkn.3) ENST00000564542 ENST00000561630 ENST00000567406
    ENST00000567010 ENST00000563573 ENST00000569045

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CDR2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDR2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CDR2 (see all 12):
    hsa-miR-376b hsa-miR-429 hsa-miR-27a hsa-miR-376a hsa-miR-3692 hsa-miR-646 hsa-miR-200c hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCDR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDR2 (see all 7)
    OriGene shRNA RFP: CDR2
    OriGene siRNA: CDR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDR2
    Sirion Biotech Custom design and validation of potent shRNA sequences against CDR2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDR2 (NM_001802)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDR2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDR2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDR2

    Additional cDNA sequence: 

    AK292273.1 BC017503.1 D12981.1 M63256.1 

    7 DOTS entries:

    DT.97842518  DT.75103832  DT.416005  DT.91803187  DT.120658652  DT.92453494  DT.92453499 

    24/278 AceView cDNA sequences (see all 278):

    AL041502 CR617156 CF529226 BQ014651 BQ637118 CA436791 F04568 AL041650 
    AI024250 BI869500 BQ649366 AW005789 AW850627 BQ019251 BX280624 BC017503 
    F09110 BF003026 AA480340 AW242907 AI096381 AK055742 AL041501 AA806399 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDR2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                                -                                 
    SP2:        -     -     -     -     -                                 
    SP3:                                                                  
    SP4:                          -     -                                 


    ECgene alternative splicing isoforms for CDR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAACTGGC
    CDR2 Expression
    About this image
    See CDR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDR2

    SOURCE GeneReport for Unigene cluster: Hs.513430
        SABiosciences Custom PCR Arrays for CDR2

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDR2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDR2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDR2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDR2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdr21 , 5 cerebellar degeneration-related 21, 5 85.87(n)1
    89.18(a)1
      7 (65.04 cM)5
    125851  NM_007672.21  NP_031698.21 
     1209570365 
    chicken
    (Gallus gallus)
    Aves CDR21 cerebellar degeneration-related protein 2, 62kDa 69.78(n)
    72.38(a)
      416621  NM_001030642.1  NP_001025813.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDR26
    --
    70(a)
    1 ↔ 1
    GL343846.1(11744-21061)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.47452 Transcribed sequence with weak similarity to protein more 76.26(n)    BQ388488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001481751 cerebellar degeneration-related protein 2-like 57.47(n)
    51.32(a)
      100148175  XM_001921397.2  XP_001921432.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cen6
    Centrocortin
    12(a)
    1 → many
    2L(20678921-20681844)


    ENSEMBL Gene Tree for CDR2 (if available)
    TreeFam Gene Tree for CDR2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDR2 gene
    CDR2L2  
    1 SIMAP similar gene for CDR2 using alignment to 6 protein entries:     CDR2_HUMAN (see all proteins):
    CDR2L

    CDR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDR2
    PGOHUM00000235530


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/398 NCBI SNPs in CDR2 are shown (see all 398    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007674581,2
    C--22356893(+) ACATT-/AATAGT
    ATAGTTTG
    AATAG
    1 -- ds50010--------
    rs1401167791,2
    --22356929(+) AGTATA/GGTTTC 1 -- ds50010--------
    rs2015568111,2
    --22357016(+) GAAAT-/AGTG  
            
    AAAAT
    1 -- ds50010--------
    rs1421240021,2
    --22357231(+) TTATAC/TTGAAA 1 -- ds50010--------
    rs1834821281,2
    --22357234(+) TATTGA/GAAGTA 1 -- ds50010--------
    rs1880885381,2
    --22357310(+) TAATCA/GGAACA 1 -- ut310--------
    rs1114357351,2
    C--22357373(+) CAGTC-/AGAAGATC 1 -- ut311Minor allele frequency- AGA:0.50CSA 2
    rs2019306631,2
    C--22357378(-) GTATTC/GATCTG 1 -- ut310--------
    rs1463753231,2
    --22357438(+) GGAATC/GGTAAG 1 -- ut310--------
    rs1927048381,2
    --22357542(+) TTGAGA/GAAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDR2 (22357257 - 22448486 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for CDR2
         3 CNVs: 49676 23249 3996
         1 Indel: 33298
         5 Inversions: 37178 0481 29493 29492 0482

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDR2 for disorders           About GeneDecksing

    OMIM gene information: 117340    OMIM disorders: --

    16 diseases for CDR2:    About MalaCards
    cerebellar degeneration    paraneoplastic cerebellar degeneration    gait apraxia    paraneoplastic neurologic disorders
    severe combined immunodeficiency    papillary renal cell carcinoma    combined immunodeficiency    renal cell carcinoma
    candidiasis    breast-ovarian cancer    ovarian cancer    lupus erythematosus
    immunodeficiency    breast cancer    carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CDR2:
    Gait apraxia

    5 Novoseek disease relationships for CDR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraneoplastic cerebellar degeneration 97 10 18053582 (2), 10465786 (1), 10500270 (1), 8545049 (1) (see all 9)
    cerebellar degeneration 86.6 5 10465786 (1), 16542365 (1), 19581925 (1), 18053582 (1)
    ovarian cancer 20.1 2 10786675 (1)
    tumors 11.4 23 19581925 (4), 10786675 (3), 10465786 (2), 20383333 (2) (see all 5)
    cancer 8.71 2 10786675 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDR2 (1 document)

    Export disorders for CDR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDR2 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with CDR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration. (PubMed id 2014264)1, 2, 3 Fathallah-Shaykh H.... Furneaux H.M. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration. (PubMed id 1763903)1, 2 Sakai K....Steinman L. (1991)
    4. Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration. (PubMed id 2260856)1, 2 Sakai K.... Steinman L. (1990)
    5. Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to att enuated hypoxic response. (PubMed id 19581925)1, 9 Balamurugan K....Camenisch G. (2009)
    6. The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. (PubMed id 10465786)1, 9 Okano H.J....Darnell R.B. (1999)
    7. PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor. (PubMed id 9637778)1, 9 Takanaga H....Ono Y. (1998)
    8. The onconeural antigen cdr2 is a novel APC/C target t hat acts in mitosis to regulate c-myc target genes in mammalian tumor cells. (PubMed id 20383333)1, 9 O'Donovan K.J....Darnell R.B. (2010)
    9. Human epidermal growth factor receptor 2 overexpressio n in breast cancer of patients with anti-Yo--associated paraneoplastic cerebella r degeneration. (PubMed id 22351748)1 Rojas-Marcos I....Graus F. (2012)
    10. CDR2 antigen and Yo antibodies. (PubMed id 21080165)1 Totland C....Vedeler C.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1039 HGNC: 1799 AceView: CDR2 Ensembl:ENSG00000140743 euGenes: HUgn1039
    ECgene: CDR2 H-InvDB: CDR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDR2 gene:
    Search GeneIP for patents involving CDR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CDR2   OriGene shRNA RFP for CDR2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDR2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDR2  
     OriGene Protein Over-expression Lysate for CDR2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CDR2   OriGene 3'-UTR Clone for CDR2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDR2   OriGene Custom Protein Services for CDR2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDR2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDR2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDR2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDR2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDR2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDR2
     GenScript Custom Purified and Recombinant Proteins Services for CDR2 GenScript cDNA clones with any tag delivered in your preferred vector for CDR2
     GenScript Custom Assay Services for CDR2 GenScript Custom Superior Antibodies Services for CDR2
     GenScript Custom overexpressing Cell Line Services for CDR2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDR2 promoter
     Search Chromatin IP Primers for CDR2
     RT2 qPCR Primer Assay in human, mouse, rat CDR2
     GNC Network for CDR2
     SABiosciences Custom PCR Arrays for CDR2
     Search Tocris compounds for CDR2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDR2 antibodies
     CDR2 proteins
     CDR2 lysates
     Antibodies for CDR2
     See all of Abcam's Antibodies, Kits and Proteins for CDR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CDR2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CDR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR2
     SwitchGear 3'UTR luciferase reporter plasmids for CDR2
     SwitchGear Promoter luciferase reporter plasmids for CDR2
     ThermoFisher Antibody for CDR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDR2
    Sirion Biotech Customized:
     stable knockdown cell line services for CDR2
     inducible knockdown cell line services for CDR2
     design and validation of potent shRNA sequences against CDR2
     adenovirus for potent knockdown of CDR2
     adenovirus for overexpression of CDR2
     stable overexpressing cell line services for CDR2
     inducible overexpressing cell line services for CDR2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDR2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4