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Aliases for CDR1 Gene

Aliases for CDR1 Gene

  • Cerebellar Degeneration Related Protein 1 2 3 5
  • Cerebellar Degeneration-Related Protein 1, 34kDa 2 3
  • CDR34 3 4
  • Cerebellar Degeneration-Related Protein-1 (34kD) 2
  • Cerebellar Degeneration-Related Protein (34kD) 2
  • CDR62A 3
  • CDR 3

External Ids for CDR1 Gene

Previous HGNC Symbols for CDR1 Gene

  • CDR

Previous GeneCards Identifiers for CDR1 Gene

  • GC0XM134395
  • GC0XM136723
  • GC0XM137810
  • GC0XM138571
  • GC0XM139590
  • GC0XM139692
  • GC0XM139865
  • GC0XM129119

Summaries for CDR1 Gene

Entrez Gene Summary for CDR1 Gene

  • Autoantibodies directed against the protein encoded by this intronless gene have been found in some patients with paraneoplastic cerebellar degeneration. The encoded protein contains several hexapeptide repeats. [provided by RefSeq, Jan 2010]

GeneCards Summary for CDR1 Gene

CDR1 (Cerebellar Degeneration Related Protein 1) is a Protein Coding gene. Diseases associated with CDR1 include 46Xy Sex Reversal 8 and Cerebellar Degeneration.

Gene Wiki entry for CDR1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR1 Gene

Genomics for CDR1 Gene

Regulatory Elements for CDR1 Gene

Enhancers for CDR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDR1 Gene

Chromosome:
X
Start:
140,782,405 bp from pter
End:
140,784,871 bp from pter
Size:
2,467 bases
Orientation:
Minus strand

Genomic View for CDR1 Gene

Genes around CDR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR1 Gene

Proteins for CDR1 Gene

  • Protein details for CDR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51861-CDR1_HUMAN
    Recommended name:
    Cerebellar degeneration-related antigen 1
    Protein Accession:
    P51861
    Secondary Accessions:
    • Q5JXH6

    Protein attributes for CDR1 Gene

    Size:
    262 amino acids
    Molecular mass:
    31279 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.
    SequenceCaution:
    • Sequence=AAA51962.1; Type=Miscellaneous discrepancy; Note=Frameshifts in positions 134, 176.; Evidence={ECO:0000305}; Sequence=AAA52472.1; Type=Frameshift; Positions=134, 176; Evidence={ECO:0000305};

neXtProt entry for CDR1 Gene

Proteomics data for CDR1 Gene at MOPED

Post-translational modifications for CDR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR1 Gene

Domains & Families for CDR1 Gene

Protein Domains for CDR1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CDR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDR1 Gene

Function for CDR1 Gene

Molecular function for CDR1 Gene

GENATLAS Biochemistry:
cerebellar degeneration-related minor antigen,34kDa,putative neuronal signal transduction protein,identified using antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder
genes like me logo Genes that share phenotypes with CDR1: view

Human Phenotype Ontology for CDR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CDR1 Gene

Localization for CDR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDR1 Gene COMPARTMENTS Subcellular localization image for CDR1 gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR1 Gene

Pathways & Interactions for CDR1 Gene

SuperPathways for CDR1 Gene

No Data Available

Interacting Proteins for CDR1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359563%0d%0a9606.ENSP00000231749%0d%0a
Selected Interacting proteins: ENSP00000359563 P51861-CDR1_HUMAN for CDR1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CDR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDR1 Gene

Drugs & Compounds for CDR1 Gene

(2) Drugs for CDR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CDR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDR1: view

Transcripts for CDR1 Gene

mRNA/cDNA for CDR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDR1 Gene

Cerebellar degeneration-related protein 1, 34kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDR1 Gene

No ASD Table

Relevant External Links for CDR1 Gene

GeneLoc Exon Structure for
CDR1
ECgene alternative splicing isoforms for
CDR1

Expression for CDR1 Gene

mRNA expression in normal human tissues for CDR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.5), Brain - Cerebellum (x9.5), Brain - Putamen (basal ganglia) (x7.8), and Brain - Caudate (basal ganglia) (x4.9).

SOURCE GeneReport for Unigene cluster for CDR1 Gene Hs.446675

mRNA Expression by UniProt/SwissProt for CDR1 Gene

P51861-CDR1_HUMAN
Tissue specificity: Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.
genes like me logo Genes that share expression patterns with CDR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CDR1 Gene

Orthologs for CDR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CDR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CDR1 35
  • 80.59 (n)
  • 69.62 (a)
mouse
(Mus musculus)
Mammalia Cdr1 36
  • 17 (a)
OneToOne
Species with no ortholog for CDR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDR1 Gene

ENSEMBL:
Gene Tree for CDR1 (if available)
TreeFam:
Gene Tree for CDR1 (if available)

Paralogs for CDR1 Gene

No data available for Paralogs for CDR1 Gene

Variants for CDR1 Gene

Sequence variations from dbSNP and Humsavar for CDR1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747835490 -- 140,784,147(+) CAAAT(C/T)CATAG reference, missense
rs748004168 -- 140,784,015(+) TTCCC(G/T)TAAAT reference, synonymous-codon
rs748276953 -- 140,783,372(+) TCCAG(C/T)AAATC utr-variant-3-prime
rs748575575 -- 140,783,623(+) CAGGT(A/C)TTCCA reference, missense
rs748674183 -- 140,786,421(+) AAGAA(G/T)TAATA upstream-variant-2KB

Variation tolerance for CDR1 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CDR1 Gene

Disorders for CDR1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDR1 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
46xy sex reversal 8
  • 46xy sex reversal 8, modifier of
cerebellar degeneration
paraneoplastic cerebellar degeneration
opportunistic mycosis
  • opportunistic mycoses
anosognosia
- elite association - COSMIC cancer census association via MalaCards
Search CDR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDR1

Genetic Association Database (GAD)
CDR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDR1
genes like me logo Genes that share disorders with CDR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR1 Gene

Publications for CDR1 Gene

  1. Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse. (PMID: 2326268) Chen Y.-T. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. Physical and genetic mapping of the CDR gene with particular reference to its position with respect to the FRAXA site. (PMID: 1708201) Siniscalco M. … Old L.J. (Am. J. Med. Genet. 1991) 3 23
  3. Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in Alzheimer's disease. (PMID: 24777548) Bosco P. … Salemi M. (Neurol. Sci. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The tolerogenic peptide, hCDR1, down-regulates the expression of interferon-I+ in murine and human systemic lupus erythematosus. (PMID: 23555966) Sthoeger Z. … Mozes E. (PLoS ONE 2013) 3

Products for CDR1 Gene

Sources for CDR1 Gene

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