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Aliases for CDR1 Gene

Aliases for CDR1 Gene

  • Cerebellar Degeneration-Related Protein 1, 34kDa 2 3
  • CDR62A 3 6
  • CDR34 3 4
  • Cerebellar Degeneration-Related Protein-1 (34kD) 2
  • Cerebellar Degeneration-Related Protein (34kD) 2
  • Cerebellar Degeneration-Related Antigen 1 3
  • CDR 3

External Ids for CDR1 Gene

Previous HGNC Symbols for CDR1 Gene

  • CDR

Previous GeneCards Identifiers for CDR1 Gene

  • GC0XM134395
  • GC0XM136723
  • GC0XM137810
  • GC0XM138571
  • GC0XM139590
  • GC0XM139692
  • GC0XM139865
  • GC0XM129119

Summaries for CDR1 Gene

Entrez Gene Summary for CDR1 Gene

  • Autoantibodies directed against the protein encoded by this intronless gene have been found in some patients with paraneoplastic cerebellar degeneration. The encoded protein contains several hexapeptide repeats. [provided by RefSeq, Jan 2010]

GeneCards Summary for CDR1 Gene

CDR1 (Cerebellar Degeneration-Related Protein 1, 34kDa) is a Protein Coding gene. Diseases associated with CDR1 include cerebellar degeneration and paraneoplastic cerebellar degeneration.

Gene Wiki entry for CDR1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR1 Gene

Genomics for CDR1 Gene

Regulatory Elements for CDR1 Gene

Genomic Location for CDR1 Gene

Start:
140,782,405 bp from pter
End:
140,784,871 bp from pter
Size:
2,467 bases
Orientation:
Minus strand

Genomic View for CDR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR1 Gene

Proteins for CDR1 Gene

  • Protein details for CDR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51861-CDR1_HUMAN
    Recommended name:
    Cerebellar degeneration-related antigen 1
    Protein Accession:
    P51861
    Secondary Accessions:
    • Q5JXH6

    Protein attributes for CDR1 Gene

    Size:
    262 amino acids
    Molecular mass:
    31279 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration
    SequenceCaution:
    • Sequence=AAA51962.1; Type=Miscellaneous discrepancy; Note=Frameshifts in positions 134, 176.; Evidence={ECO:0000305}; Sequence=AAA52472.1; Type=Frameshift; Positions=134, 176; Evidence={ECO:0000305};

neXtProt entry for CDR1 Gene

Proteomics data for CDR1 Gene at MOPED

Post-translational modifications for CDR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR1 Gene

Domains for CDR1 Gene

Protein Domains for CDR1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CDR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDR1 Gene

Function for CDR1 Gene

Molecular function for CDR1 Gene

GENATLAS Biochemistry:
cerebellar degeneration-related minor antigen,34kDa,putative neuronal signal transduction protein,identified using antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder

Gene Ontology (GO) - Molecular Function for CDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDR1: view

Animal Model Products

CRISPR Products

miRNA for CDR1 Gene

miRTarBase miRNAs that target CDR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDR1 Gene

Localization for CDR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDR1 Gene COMPARTMENTS Subcellular localization image for CDR1 gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR1 Gene

Pathways for CDR1 Gene

SuperPathways for CDR1 Gene

No Data Available

Interacting Proteins for CDR1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359563%0d%0a9606.ENSP00000231749%0d%0a
Selected Interacting proteins: ENSP00000359563 P51861-CDR1_HUMAN for CDR1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CDR1 Gene

None

No data available for Pathways by source for CDR1 Gene

Compounds for CDR1 Gene

(5) Novoseek inferred chemical compound relationships for CDR1 Gene

Compound -log(P) Hits PubMed IDs
pyrrole 70.8 1
fluconazole 68.4 2
anti-fungal 44.3 1
oligonucleotide 26.1 1
atp 25.3 2
genes like me logo Genes that share compounds with CDR1: view

Transcripts for CDR1 Gene

mRNA/cDNA for CDR1 Gene

(2) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDR1 Gene

Cerebellar degeneration-related protein 1, 34kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDR1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDR1 Gene

No ASD Table

Relevant External Links for CDR1 Gene

GeneLoc Exon Structure for
CDR1
ECgene alternative splicing isoforms for
CDR1

Expression for CDR1 Gene

mRNA expression in normal human tissues for CDR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.5), Brain - Cerebellum (9.5), Brain - Putamen (basal ganglia) (7.8), and Brain - Caudate (basal ganglia) (4.9).

SOURCE GeneReport for Unigene cluster for CDR1 Gene Hs.446675

mRNA Expression by UniProt/SwissProt for CDR1 Gene

P51861-CDR1_HUMAN
Tissue specificity: Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors
genes like me logo Genes that share expressions with CDR1: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for CDR1 Gene

Orthologs for CDR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CDR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CDR1 35
  • 80.59 (n)
  • 69.62 (a)
mouse
(Mus musculus)
Mammalia Cdr1 16
Cdr1 36
  • 17 (a)
OneToOne
Species with no ortholog for CDR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDR1 Gene

ENSEMBL:
Gene Tree for CDR1 (if available)
TreeFam:
Gene Tree for CDR1 (if available)

Paralogs for CDR1 Gene

No data available for Paralogs for CDR1 Gene

Variants for CDR1 Gene

Sequence variations from dbSNP and Humsavar for CDR1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3761509 -- 140,786,313(+) ATCGT(C/T)TGTGG upstream-variant-2KB
rs5954092 -- 140,784,933(+) TAAAA(A/G)TAATG upstream-variant-2KB
rs5954093 -- 140,785,027(+) CAGTT(G/T)ACTAT upstream-variant-2KB
rs5954094 -- 140,785,210(+) aataa(C/T)aacaa upstream-variant-2KB
rs5954095 -- 140,786,439(+) TGACT(C/T)TGAAG upstream-variant-2KB

Relevant External Links for CDR1 Gene

HapMap Linkage Disequilibrium report
CDR1
Locus Specific Mutation Databases (LSDB)
CDR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDR1 Gene

Disorders for CDR1 Gene

(3) University of Copenhagen DISEASES for CDR1 Gene

(1) Novoseek inferred disease relationships for CDR1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 25 1

Relevant External Links for CDR1

Genetic Association Database (GAD)
CDR1
genes like me logo Genes that share disorders with CDR1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CDR1 Gene

Publications for CDR1 Gene

  1. Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse. (PMID: 2326268) Chen Y.-T. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  2. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. (PMID: 3474619) Dropcho E.J. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4
  3. Physical and genetic mapping of the CDR gene with particular reference to its position with respect to the FRAXA site. (PMID: 1708201) Siniscalco M. … Old L.J. (Am. J. Med. Genet. 1991) 3 23
  4. A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles. (PMID: 8099917) Sasso E.H. … Milner E.C. (J. Clin. Invest. 1993) 23
  5. Analysis of the interaction between the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) and the human T-cell receptor. (PMID: 9140976) Kline J.B. … Collins C.M. (Mol. Microbiol. 1997) 23

Products for CDR1 Gene

Sources for CDR1 Gene

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