CDR1 Gene
protein-coding GIFtS: 44
GCID: GC0XM139865
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|
cerebellar degeneration-related protein 1, 34kDa(Previous name: cerebellar degeneration-related protein (34kD) )
(Previous symbol: CDR)
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Aliases
for CDR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cerebellar Degeneration-Related Protein 1, 34kDa1 2 | | CDR341 2 3 | | CDR62A1 2 5 | | CDR1 2 | | Cerebellar Degeneration-Related Protein (34kD)1 | | Cerebellar Degeneration-Related Antigen 12 |
Export aliases for CDR1 gene to outside databasesPrevious GC identifers: GC0XM134395 GC0XM136723 GC0XM137810 GC0XM138571 GC0XM139590 GC0XM139692 GC0XM129119 |
Summaries
for CDR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDR1:
Autoantibodies directed against the protein encoded by this intronless gene have been found in some patients withparaneoplastic cerebellar degeneration. The encoded protein contains several hexapeptide repeats. (provided by RefSeq,Jan 2010)
Gene Wiki entry for CDR1
|
Genomic Views
for CDR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDR1 gene promoter:
NF-AT4 NF-AT2 NF-AT3 NF-AT NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.1-q27.2 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq27.1-q27.2CDR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM139865: view genomic region
(about GC identifiers)
Start:
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139,865,425 bp from pter |
End:
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139,866,723 bp from pter |
Size:
|
1,299 bases |
Orientation:
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minus strand |
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Proteins
for CDR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDR1_HUMAN, P51861 (See
protein sequence)Recommended Name: Cerebellar degeneration-related antigen 1 Size: 262 amino acids; 31279 Da
Miscellaneous: Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration
Sequence caution: Sequence=AAA51962.1; Type=Miscellaneous discrepancy; Note=Frameshifts in positions 134, 176;Sequence=AAA52472.1; Type=Frameshift; Positions=134, 176;
Secondary accessions: Q5JXH6Explore the universe of human proteins at neXtProt for CDR1: NX_P51861
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51861
CDR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004056.2
ENSEMBL proteins: ENSP00000359563
Human Recombinant Protein Products for CDR1:
CDR1 Antibody Products:
Assay Products for CDR1: |
Protein
Domains /
Families
for CDR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P51861 |
Function
for CDR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
Genatlas biochemistry entry for CDR1:cerebellar degeneration-related minor antigen,34kDa,putative neuronal signal transduction protein,identified usingantisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDR1 (NM_004065) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR1 |
|
Pathways & Interactions
for CDR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDR1
|
Drugs & Compounds
for CDR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDR1 for compounds About GeneDecksing
 Browse Tocris compounds for CDR1
5 Novoseek chemical compound relationships for CDR1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pyrrole |
70.8 |
1 |
9210670 (1) |
| fluconazole |
68.4 |
2 |
9767132 (1), 12019078 (1) |
| anti-fungal |
44.3 |
2 |
10952571 (1) |
| oligonucleotide |
26.1 |
1 |
8099917 (1) |
| atp |
25.3 |
2 |
9767132 (1), 10952571 (1) |
Search CenterWatch for drugs/clinical trials and news about CDR1
|
Transcripts
for CDR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDR1 gene: NM_004065.2 Unigene Cluster for CDR1: Cerebellar degeneration-related protein 1, 34kDa Hs.446675 [show with all ESTs]Unigene Representative Sequence: NM_0040651 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370532(uc004fbg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDR1 (NM_004065) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR1 |
Additional cDNA sequence: BC113472.1 BC113474.1 M16965.1 11 DOTS entries: DT.95090928 DT.95231414 DT.95203061 DT.97866800 DT.100774434 DT.121320635 DT.95135866 DT.312181 DT.91762157 DT.95090936 DT.95327888 2 AceView cDNA sequences: NM_004065 M16965
GeneLoc Exon Structure
|
Expression
for CDR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTGTCTGG
About this image
See CDR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDR1
SOURCE GeneReport for Unigene cluster: Hs.446675
UniProtKB/Swiss-Prot: CDR1_HUMAN, P51861Tissue specificity: Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors
SABiosciences Custom PCR Arrays for CDR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CDR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR1 |
Orthologs
for CDR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for CDR1 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cdr15 |
cerebellar degeneration related antigen 1 |
-- |
|
X (34.33 cM) 61183246 |
ENSEMBL Gene Tree for CDR1 (if available)
TreeFam Gene Tree for CDR1 (if available) |
Paralogs
for CDR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CDR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDR1 (139865425 - 139866723 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CDR1
2 CNVs: 97024 83790
Locus Specific Mutation Databases (LSDB): CDR1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDR1 |
|
Disorders
/ Diseases
for CDR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDR1 for disorders About GeneDecksing
OMIM gene information: 302650
OMIM disorders: --
11  diseases for CDR1: About MalaCardscerebellar degeneration paraneoplastic cerebellar degeneration blue cone monochromacy paraneoplastic neurologic disorders
systemic lupus erythematosus lupus erythematosus candidiasis breast-ovarian cancer
ovarian cancer immunodeficiency neuronitis
2 diseases from the University of Copenhagen DISEASES database for CDR1:Systemic lupus erythematosus Alzheimer's disease 1 Novoseek disease relationship for CDR1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| immunodeficiency |
25 |
1 |
9210670 (1) |
Export disorders for CDR1 gene to outside databases
|
Publications
for CDR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDR1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with CDR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse. (PubMed id 2326268)1, 2, 3 Chen Y.-T.... Old L.J. (1990)
- Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. (PubMed id 3474619)1, 2 Dropcho E.J.... Old L.J. (1987)
- Physical and genetic mapping of the CDR gene with particular reference to its position with respect to the FRAXA site. (PubMed id 1708201)1, 9 Siniscalco M....Old L.J. (1991)
- miRNA-dependent gene silencing involving Ago2-mediate d cleavage of a circular antisense RNA. (PubMed id 21964070)1 Hansen T.B....Kjems J. (2011)
- Overexpression of CDR1 and CDR2 genes plays an import ant role in fluconazole resistance in Candida albicans with G487T and T916C mut ations. (PubMed id 20515567)1 Chen L.M....Wang R. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach. (PubMed id 11846061)1 Mizoshita T....Tatematsu M. (2001)
- Transcriptional analyses of antifungal drug resistance in Candida albicans. (PubMed id 10952571)9 Lyons C.N. and White T.C. (2000)
|
External Searches for CDR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CDR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDR1 gene:
Search GeneIP for patents involving CDR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDR1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDR1 | | OriGene 3'-UTR Clone for CDR1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDR1 |
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| | | | Search Tocris compounds for CDR1 |
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 | | | CDR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDR1 |
|  |  |  |  | | | | ThermoFisher Antibodies for CDR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDR1 |
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