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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDON Gene

protein-coding   GIFtS: 63
GCID: GC11M125866

Cell Adhesion Associated, Oncogene Regulated

(Previous name: Cdon homolog (mouse))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Adhesion Associated, Oncogene Regulated1 2     HPE112
Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes1 2     ORCAM2
CDO2 3     Cdon Homolog2
Cdon Homolog (Mouse)1     Surface Glycoprotein, Ig Superfamily Member2
CDON12     

External Ids:    HGNC: 171041   Entrez Gene: 509372   Ensembl: ENSG000000643097   OMIM: 6087075   UniProtKB: Q4KMG03   

Export aliases for CDON gene to outside databases

Previous GC identifers: GC11M127831 GC11M127343 GC11M125368 GC11M125335 GC11M121768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDON Gene:
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein
contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a
member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and
positively regulates myogenesis. (provided by RefSeq, Aug 2011)

GeneCards Summary for CDON Gene: 
CDON (cell adhesion associated, oncogene regulated) is a protein-coding gene. Diseases associated with CDON include cdon-related holoprosencephaly, and duodenal obstruction, and among its related super-pathways are Myogenesis and Axon guidance. GO annotations related to this gene include protein binding. An important paralog of this gene is NEO1.

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle
precursor cells. Promotes differentiation of myogenic cells (By similarity)

Gene Wiki entry for CDON Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDON gene promoter:
         E2F-3a   E2F-4   E2F-5   MyoD   E2F-2   E2F   E2F-1   POU2F1   POU2F1a   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDON promoter sequence
   Search SABiosciences Chromatin IP Primers for CDON

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDON


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

CDON Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDON gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M125866:  view genomic region     (about GC identifiers)

Start:
125,825,691 bp from pter      End:
125,933,230 bp from pter
Size:
107,540 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0 (See protein sequence)
Recommended Name: Cell adhesion molecule-related/down-regulated by oncogenes precursor  
Size: 1287 amino acids; 139147 Da
Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By
similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (Potential)
3 PDB 3D structures from and Proteopedia for CDON:
3D1M (3D)        3N1F (3D)        3N1Q (3D)    
Secondary accessions: O14631
Alternative splicing: 2 isoforms:  Q4KMG0-1   Q4KMG0-2   

Explore the universe of human proteins at neXtProt for CDON: NX_Q4KMG0

Explore proteomics data for CDON at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4KMG0

  • CDON Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDON Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230526.1  NP_058648.4  

    ENSEMBL proteins: 
     ENSP00000376458   ENSP00000432901   ENSP00000263577   ENSP00000436755   ENSP00000432571  
     ENSP00000434212   ENSP00000436940   ENSP00000437176  
    Reactome Protein details: Q4KMG0
    Human Recombinant Protein Products for CDON: 
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    Novus Biologicals CDON Protein
    Novus Biologicals CDON Lysate
    Sino Biological Recombinant Protein for CDON
    Sino Biological Cell Lysate for CDON 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031012colocalizes with extracellular matrix TAS--

    CDON for ontologies           About GeneDecksing



    CDON Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q4KMG0

    ProtoNet protein and cluster: Q4KMG0

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    CDON for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDON_HUMAN, Q4KMG0
    Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle
    precursor cells. Promotes differentiation of myogenic cells (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11782431
         
    CDON for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdon):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     growth/size  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton  vision/eye 

    CDON for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDON: Cdontm1Aok Cdontm1Rsk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDON 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDON

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDON 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDON 

    miRNA
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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate CDON (see all 71):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-146a hsa-miR-200a hsa-miR-3138 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDON 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDON About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2Axon guidance
    Developmental Biology0.69
    3Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CDON
        Signaling events mediated by the Hedgehog family


    3        Reactome Pathways for CDON
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    CDON for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDON

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for CDON (Q4KMG02, 3 ENSP000002635774) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-7221388 MINT-7221365 I2D: score=2 STRING: ENSP00000361423
    BOCQ9BWV13, ENSP000003475464I2D: score=2 STRING: ENSP00000347546
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CDH15P552913, ENSP000002897464I2D: score=1 STRING: ENSP00000289746
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001708cell fate specification IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0002088lens development in camera-type eye IEA--
    GO:0007155cell adhesion TAS9214393
    GO:0007224smoothened signaling pathway IEA--

    CDON for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDON

    Search CenterWatch for drugs/clinical trials and news about CDON

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDON gene (2 alternative transcripts): 
    NM_001243597.1  NM_016952.4  

    Unigene Cluster for CDON:

    Cell adhesion associated, oncogene regulated
    Hs.38034  [show with all ESTs]
    Unigene Representative Sequence: NM_001243597
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392693(uc001qdb.4 uc009zbw.3 uc001qdc.4) ENST00000531738
    ENST00000263577 ENST00000534661(uc001qdd.4) ENST00000531830 ENST00000525625(uc009zbx.3)
    ENST00000531586 ENST00000527967 ENST00000534818
    miRNA
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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate CDON (see all 71):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-146a hsa-miR-200a hsa-miR-3138 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDON 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209396.1 AF004841.2 AF086259.1 AK022986.1 AK309694.1 BC098583.1 BC112362.1 BC114435.1 

    4 DOTS entries:

    DT.40122115  DT.95130287  DT.120717624  DT.40130993 

    17 AceView cDNA sequences:

    AA435888 BX492188 BV179989 CA406818 AF004841 NM_016952 CA407337 BV180409 
    AA398836 BE542045 BQ694971 BG924472 BX282476 AL832223 BX647207 CF594141 
    BE154333 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDON    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
    SP1:        -                                                           -                                                                 -               
    SP2:        -                                                           -                                                                                 
    SP3:                                                                                                                                      -               
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for CDON

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDON expression in normal human tissues (normalized intensities)      CDON embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGTATCA
    CDON Expression
    About this image


    CDON expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Limb (Muscoskeletal System)
             Autopod
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Heart (Cardiovascular System)

    See CDON Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDON

    SOURCE GeneReport for Unigene cluster: Hs.38034
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDON: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDON

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDON gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdon1 , 5 cell adhesion molecule-related/down-regulated by oncogenes1, 5 82.48(n)1
    82.56(a)1
      9 (20.24 cM)5
    578101  NM_021339.21  NP_067314.21 
     354211285 
    chicken
    (Gallus gallus)
    Aves CDON1 Cdon homolog (mouse) 59.48(n)
    57.63(a)
      419710  XM_417853.3  XP_417853.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDON6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343322.1(301048-324114)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdon-A2 cell adhesion molecule-related/down-regulated by oncogenes 75.28(n)    AF388035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10c022 wufa10c02 76.7(n)   334938  CA408053.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta boi1 brother of ihog 40.19(n)
    29.19(a)
      31229  NM_001201611.1  NP_001188540.1 


    ENSEMBL Gene Tree for CDON (if available)
    TreeFam Gene Tree for CDON (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDON gene
    NEO12  IGDCC42  FNDC3B2  BOC2  SDK22  DCC2  SDK12  PRTG2  
    IGDCC32  FNDC3A2  
    7 SIMAP similar genes for CDON using alignment to 7 protein entries:     CDON_HUMAN (see all proteins):
    MUSK    BOC    FGFR3    DCC    OBSCN    HMCN2
    TTN

    CDON for paralogs           About GeneDecksing


    5/13 Pseudogenes.org Pseudogenes for CDON (see all 13)
    PGOHUM00000257813 PGOHUM00000242410 PGOHUM00000242411 PGOHUM00000257903 PGOHUM00000257904


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2510 SNPs in CDON are shown (see all 2510)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0665014
    Holoprosencephaly 11 (HPE11)4--see VAR_0665012 T A mis40--------
    VAR_0664984
    Holoprosencephaly 11 (HPE11)4--see VAR_0664982 P A mis40--------
    VAR_0665024
    Holoprosencephaly 11 (HPE11)4--see VAR_0665022 S R mis40--------
    VAR_0665004
    Holoprosencephaly 11 (HPE11)4--see VAR_0665002 V E mis40--------
    VAR_0664994
    Holoprosencephaly 11 (HPE11)4--see VAR_0664992 V M mis40--------
    rs1459834701,2,4
    C,FHoloprosencephaly 11 (HPE11)4 --125738149(+) CCTGGG/CTGTTT 4 /T /S mis12Minor allele frequency- C:0.01NA EU 5875
    rs1412214341,2
    Cuntested1125753457(+) TTTCCA/C/GGAGTC 4 S syn10--------
    rs358289391,2
    C--121784888(+) TTTTT-/TTTTTT 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1430146171,2
    C--121786210(+) CATTT-/GTA   
       GGTAG
    GTAGG
    2 -- int10--------
    rs1123453521,2
    C--121786231(+) GTAGGA/TAGGTA 2 -- int11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for CDON (125825691 - 125933230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDON:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819513CNV Loss19587683
    nsv535CNV Loss18451855
    esv32964CNV Gain+Loss17666407


    Human Gene Mutation Database (HGMD): CDON
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDON
    DNA2.0 Custom Variant and Variant Library Synthesis for CDON

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608707    OMIM disorders: --

    UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0
  • Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing
    forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically
    heterogeneous and associated with several distinct facies and phenotypic variability. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 13 diseases for CDON:    About MalaCards
    cdon-related holoprosencephaly    duodenal obstruction    microform holoprosencephaly    blind loop syndrome
    holoprosencephaly    duodenitis    blindness    rhabdomyosarcoma
    cerebritis    alzheimer's disease    prostatitis    neuronitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CDON:
    Holoprosencephaly

    CDON for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDON
    Human Genome Epidemiology (HuGE) Navigator: CDON (1 document)

    Export disorders for CDON gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDON gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CDON)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PubMed id 9214393)1, 2, 3, 9 Kang J.-S....Krauss R.S. (1997)
    2. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. (PubMed id 21802063)1, 2 Bae G.U....Krauss R.S. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PubMed id 12634428)1, 9 Kang J.-S.... Krauss R.S. (2003)
    6. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. (PubMed id 12720294)1, 9 Wegorzewska M....Kang J.S. (2003)
    7. Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication. (PubMed id 22326621)1 Sanchez-Arrones L....Bovolenta P. (2012)
    8. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    9. Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. (PubMed id 22881374)1 Cummings A.C....Haines J.L. (2012)
    10. Identification of transmembrane protein in prostate c ancer by the Escherichia coli ampicillin secretion trap: expression of CDON is involved in tumor cell growth and invasion. (PubMed id 21849809)1 Hayashi T....Yasui W. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50937 HGNC: 17104 AceView: CDON Ensembl:ENSG00000064309 euGenes: HUgn50937
    ECgene: CDON H-InvDB: CDON

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDON Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDON Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDON gene:
    Search GeneIP for patents involving CDON

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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