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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDON Gene

protein-coding GIFtS: 60
GCID: GC11M125866

cell adhesion associated, oncogene regulated

(Previous name: Cdon homolog (mouse) )

Explore 9 diseases affiliated with
CDON via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Adhesion Associated, Oncogene Regulated¹ ²		HPE11²
CDO¹ ² ³		Cdon Homolog²
CDON1¹ ²		Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes²
ORCAM¹ ²		Surface Glycoprotein, Ig Superfamily Member²
Cdon Homolog (Mouse)¹

External Ids:	HGNC: 17104¹	Entrez Gene: 50937²	Ensembl: ENSG00000064309⁷	OMIM: 608707⁵	UniProtKB: Q4KMG0³

Export aliases for CDON gene to outside databases

Previous GC identifers: GC11M127831 GC11M127343 GC11M125368 GC11M125335 GC11M121768

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDON:

This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein

contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of

a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively

regulates myogenesis. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0

Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor

cells. Promotes differentiation of myogenic cells (By similarity)

Gene Wiki entry for CDON

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDON gene promoter:
E2F-3a E2F-4 E2F-5 MyoD E2F-2 E2F E2F-1 POU2F1 POU2F1a COMP1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDON promoter sequence

Search SABiosciences Chromatin IP Primers for CDON

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDON

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24.2

CDON Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDON gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M125866: view genomic region (about GC identifiers)

Start:	125,825,691 bp from pter	End:	125,933,230 bp from pter
Size:	107,540 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0 (See protein sequence)

Recommended Name: Cell adhesion molecule-related/down-regulated by oncogenes precursor

Size: 1287 amino acids; 139147 Da

Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity).

Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity)

Subcellular location: Membrane; Single-pass membrane protein (Potential)

3 PDB 3D structures from and Proteopedia for CDON:

3D1M (3D)

3N1F (3D)

3N1Q (3D)

Secondary accessions: O14631

Alternative splicing: 2 isoforms: Q4KMG0-1 Q4KMG0-2

Explore the universe of human proteins at neXtProt for CDON: NX_Q4KMG0

Post-translational modifications:

N-glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q4KMG0

CDON Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230526.1 NP_058648.4

ENSEMBL proteins:

ENSP00000376458 ENSP00000432901 ENSP00000263577 ENSP00000436755 ENSP00000432571

ENSP00000434212 ENSP00000436940 ENSP00000437176

Reactome Protein details: Q4KMG0
Human Recombinant Protein Products for CDON:

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	Novus Biologicals CDON Protein Novus Biologicals CDON Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDON

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0009986	cell surface	--	--
GO:0016021	integral to membrane	IEA	--
GO:0031012	colocalizes with extracellular matrix	TAS	--

CDON for ontologies About GeneDecksing

CDON Antibody Products:

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	Novus Biologicals CDON Antibodies
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Assay Products for CDON:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDON

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDON for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q4KMG0

ProtoNet protein and cluster: Q4KMG0

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0

Similarity: Contains 3 fibronectin type-III domains

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDON_HUMAN, Q4KMG0

Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor

cells. Promotes differentiation of myogenic cells (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11782431

CDON for ontologies About GeneDecksing

Phenotypes:
12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdon):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
growth/size	limbs/digits/tail	mortality/aging	nervous system	respiratory system
skeleton	vision/eye

CDON for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CDON: Cdon^tm1Aok Cdon^tm1Rsk

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDON

miRNA Products:		OriGene 3'-UTR Clone: CDON Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDON
		8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate CDON (see all 71):
		hsa-miR-323-3p hsa-miR-100* hsa-miR-146a hsa-miR-200a hsa-miR-3138 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: CDON 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDON (see all 7) OriGene shRNA RFP: CDON OriGene siRNA: CDON
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDON
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDON

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CDON
			Sirion Biotech Customized adenovirus for overexpression of CDON Sirion Biotech Customized adenovirus for potent knockdown of CDON

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDON (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDON OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDON (NM_016952)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDON
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDON

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDON
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		Sirion Biotech Customized stable knockdown cell line services for CDON Sirion Biotech Customized inducible knockdown cell line services for CDON Sirion Biotech Customized stable overexpressing cell line services for CDON Sirion Biotech Customized inducible overexpressing cell line services for CDON

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDON

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of p38 alpha/beta MAPK

	Activation of p38 alpha/beta MAPK	1.00			CDO in myogenesis	0.55
	Nuclear translocation of p38 MAPK	0.94			Myogenesis	0.55

Signaling events mediated by the Hedgehog family

Signaling events mediated by the Hedgehog family

1.00

Axon guidance

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for CDON

Signaling events mediated by the Hedgehog family

5 Reactome Pathways for CDON

	Activation of p38 alpha/beta MAPK
	Developmental Biology
	Myogenesis
	Nuclear translocation of p38 MAPK
	CDO in myogenesis

CDON for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDON

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/23 Interacting proteins for CDON (Q4KMG0^{2, 3} ENSP00000263577⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-7221388 MINT-7221365 I2D: score=2 STRING: ENSP00000361423
BOC	Q9BWV1³, ENSP00000347546⁴	I2D: score=2 STRING: ENSP00000347546
CDH2	P19022³, ENSP00000269141⁴	I2D: score=2 STRING: ENSP00000269141
CDH1	P12830³, ENSP00000261769⁴	I2D: score=1 STRING: ENSP00000261769
CDH15	P55291³, ENSP00000289746⁴	I2D: score=1 STRING: ENSP00000289746

About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001708	cell fate specification	IEA	--
GO:0001934	positive regulation of protein phosphorylation	IEA	--
GO:0002088	lens development in camera-type eye	IEA	--
GO:0007155	cell adhesion	TAS	9214393
GO:0007224	smoothened signaling pathway	IEA	--

CDON for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDON
Search CenterWatch for drugs/clinical trials and news about CDON

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDON gene (2 alternative transcripts):

NM_001243597.1 NM_016952.4

Unigene Cluster for CDON:

Cell adhesion associated, oncogene regulated

Hs.38034 [show with all ESTs]

Unigene Representative Sequence: NM_001243597

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392693(uc001qdb.4 uc009zbw.3 uc001qdc.4) ENST00000531738

ENST00000263577 ENST00000534661(uc001qdd.4) ENST00000531830 ENST00000525625(uc009zbx.3)

ENST00000531586 ENST00000527967 ENST00000534818

miRNA Products:		OriGene 3'-UTR Clone: CDON Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDON
		8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate CDON (see all 71):
		hsa-miR-323-3p hsa-miR-100* hsa-miR-146a hsa-miR-200a hsa-miR-3138 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: CDON 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDON (see all 7) OriGene shRNA RFP: CDON OriGene siRNA: CDON
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDON
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDON

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDON (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDON OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDON (NM_016952)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDON
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDON

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDON Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDON
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDON
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDON

Additional cDNA sequence:

AB209396.1 AF004841.2 AF086259.1 AK022986.1 AK309694.1 BC098583.1 BC112362.1 BC114435.1

4 DOTS entries:

DT.40122115 DT.95130287 DT.120717624 DT.40130993

17 AceView cDNA sequences:

CA406818 BV180409 CA407337 NM_016952 BV179989 AA435888 BX492188 AF004841

AA398836 BQ694971 BX282476 BE542045 BG924472 AL832223 BX647207 CF594141

BE154333

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CDON About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b
SP1:			-																				-																						-
SP2:			-																				-
SP3:																																													-
SP4:

ECgene alternative splicing isoforms for CDON

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDON expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTGTATCA

About this image

CDON expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDON Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDON

SOURCE GeneReport for Unigene cluster: Hs.38034

SABiosciences Expression via Pathway-Focused PCR Arrays including CDON:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Targets in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDON

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDON

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CDON gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDON¹	Cdon homolog (mouse)	59.48(n) 57.63(a)		419710 XM_417853.3 XP_417853.3
lizard (Anolis carolinensis)	Reptilia	CDON⁶	--	62(a)	1 ↔ 1	GL343322.1(301048-324053)
African clawed frog (Xenopus laevis)	Amphibia	cdon-A²	cell adhesion molecule-related/down-regulated by oncogenes	75.28(n)		AF388035.1
zebrafish (Danio rerio)	Actinopterygii	wufa10c02²	wufa10c02	76.7(n)		334938 CA408053.1
fruit fly (Drosophila melanogaster)	Insecta	boi¹	brother of ihog	40.19(n) 29.19(a)		31229 NM_001201611.1 NP_001188540.1

ENSEMBL Gene Tree for CDON (if available)
TreeFam Gene Tree for CDON (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDON gene

ROBO2² ROBO1² NEO1² ROBO4² IGDCC4² BOC² DCC² PRTG²

IGDCC3² ROBO3²

9 SIMAP similar genes for CDON using alignment to 7 protein entries: CDON_HUMAN (see all proteins):

MUSK BOC FGFR3 DCC OBSCN HMCN2

TTN CNTN4 IGLV3-25

CDON for paralogs About GeneDecksing

5/13 Pseudogenes.org Pseudogenes for CDON (see all 13)
PGOHUM00000257813 PGOHUM00000242410 PGOHUM00000242411 PGOHUM00000257903 PGOHUM00000257904

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141221434^1,2	C	other	123400784(+)	`TTTCCA/C/GGAGTC`	6	S	syn¹		0	--	--	--	--
rs78946779^1,2	F	--	121768409(+)	`GGAGCT/GGGCCC`	3	--	ds500¹ int¹		1		EA	120
rs79685272^1,2	C,F	--	121768728(+)	`GGTTTC/TGGCTA`	3	--	ut3¹ int¹		1		WA	118
rs61917811^1,2		--	121768889(+)	`AAACAG/AAACGT`	3	--	ut3¹ int¹		1		NA	2
rs73019367^1,2	C	--	121768946(+)	`GCGCTC/AGGTTA`	3	--	ut3¹ int¹		3		CSA WA	121
rs116746244^1,2	C,F	--	121768978(+)	`TGAGGC/TGGGAC`	3	--	ut3¹ int¹		1		WA	118
rs74527873^1,2		--	121769031(+)	`CTTCCC/TTCCAA`	3	--	ut3¹ int¹		2		CSA WA	119
rs77815115^1,2	F	--	121769294(+)	`AGTATT/CCCCAC`	3	--	ut3¹ int¹		1		WA	118
rs73019370^1,2	C	--	121769732(+)	`GAAAAA/TCATTA`	3	--	ut3¹ int¹		0	--	--	--	--
rs116579152^1,2	C,F	--	121769816(+)	`GAAGGA/GACATG`	3	--	ut3¹ int¹		1		WA	118

HapMap Linkage Disequilibrium report for CDON (125825691 - 125933230 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CDON
2 CNVs: 58499 6905
Human Gene Mutation Database (HGMD): CDON

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDON

DNA2.0 Custom Variant and Variant Library Synthesis for CDON

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDON for disorders About GeneDecksing

OMIM gene information: 608707 OMIM disorders: --

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0

Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:614226]. HPE11 is a structural anomaly

of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres.

Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability

9 diseases for CDON: About MalaCards

blind loop syndrome duodenal obstruction holoprosencephaly duodenitis

blindness rhabdomyosarcoma cerebritis prostatitis

neuronitis

1 disease from the University of Copenhagen DISEASES database for CDON:

Holoprosencephaly

Human Genome Epidemiology (HuGE) Navigator: CDON (1 document)

Export disorders for CDON gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDON gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with CDON)

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CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PubMed id 9214393)^{1, 2, 3, 9} Kang J.-S....Krauss R.S. (1997)
Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. (PubMed id 21802063)^{1, 2} Bae G.U....Krauss R.S. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PubMed id 12634428)^{1, 9} Kang J.-S.... Krauss R.S. (2003)
Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. (PubMed id 12720294)^{1, 9} Wegorzewska M....Kang J.S. (2003)
Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication. (PubMed id 22326621)¹ Sanchez-Arrones L....Bovolenta P. (2012)
Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)¹ Eriksson N....Tung J.Y. (2012)
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. (PubMed id 22881374)¹ Cummings A.C....Haines J.L. (2012)
Identification of transmembrane protein in prostate c ancer by the Escherichia coli ampicillin secretion trap: expression of CDON is involved in tumor cell growth and invasion. (PubMed id 21849809)¹ Hayashi T....Yasui W. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 50937	HGNC: 17104	AceView: CDON	Ensembl:ENSG00000064309	euGenes: HUgn50937
ECgene: CDON	H-InvDB: CDON

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDON	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDON	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CDON gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDON gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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