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CDON Gene

protein-coding   GIFtS: 64
GCID: GC11M125866

Cell Adhesion Associated, Oncogene Regulated

(Previous name: Cdon homolog (mouse))
  See CDON-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Adhesion Associated, Oncogene Regulated1 2     CDON12
CDO2 3 5     ORCAM2
Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes1 2     Cdon Homolog2
HPE112 5     Surface Glycoprotein, Ig Superfamily Member2
Cdon Homolog (Mouse)1     

External Ids:    HGNC: 171041   Entrez Gene: 509372   Ensembl: ENSG000000643097   OMIM: 6087075   UniProtKB: Q4KMG03   

Export aliases for CDON gene to outside databases

Previous GC identifers: GC11M127831 GC11M127343 GC11M125368 GC11M125335 GC11M121768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDON Gene:
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein
contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a
member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and
positively regulates myogenesis. (provided by RefSeq, Aug 2011)

GeneCards Summary for CDON Gene:
CDON (cell adhesion associated, oncogene regulated) is a protein-coding gene. Diseases associated with CDON include holoprosencephaly 11, and cdon-related holoprosencephaly. An important paralog of this gene is BOC.

UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle
precursor cells. Promotes differentiation of myogenic cells (By similarity)

Gene Wiki entry for CDON Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDON gene promoter:
         E2F-3a   E2F-4   E2F-5   MyoD   E2F-2   E2F   E2F-1   POU2F1   POU2F1a   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDON promoter sequence
   Search Chromatin IP Primers for CDON

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDON


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

CDON Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDON gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M125866:  view genomic region     (about GC identifiers)

Start:
125,825,691 bp from pter      End:
125,933,230 bp from pter
Size:
107,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0 (See protein sequence)
Recommended Name: Cell adhesion molecule-related/down-regulated by oncogenes precursor  
Size: 1287 amino acids; 139147 Da
Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By
similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH
and SHH
3 PDB 3D structures from and Proteopedia for CDON:
3D1M (3D)        3N1F (3D)        3N1Q (3D)    
Secondary accessions: O14631
Alternative splicing: 2 isoforms:  Q4KMG0-1   Q4KMG0-2   

Explore the universe of human proteins at neXtProt for CDON: NX_Q4KMG0

Explore proteomics data for CDON at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn88, Asn100, Asn180, Asn287, Asn294, Asn342, Asn427, Asn570, Asn873, Ser932
  • Modification sites at PhosphoSitePlus

  • See CDON Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230526.1  NP_058648.4  

    ENSEMBL proteins: 
     ENSP00000376458   ENSP00000432901   ENSP00000263577   ENSP00000436755   ENSP00000432571  
     ENSP00000434212   ENSP00000436940   ENSP00000437176  
    Reactome Protein details: Q4KMG0

    CDON Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CDON (CDO)
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    OriGene Protein Over-expression Lysate for CDON
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    Novus Biologicals CDON Protein
    Novus Biologicals CDON Lysate
    Sino Biological Recombinant Protein for CDON
    Sino Biological Cell Lysate for CDON
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CDON 

     
    antibodies-online proteins for CDON (6 products) 

     
    Search antibodies-online for peptides for CDON

    CDON Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDON
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    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CDON
    antibodies-online antibodies for CDON (33 products) 

    CDON Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CDON 
    antibodies-online kits for CDON (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q4KMG0

    ProtoNet protein and cluster: Q4KMG0

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with CDON           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDON_HUMAN, Q4KMG0
    Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle
    precursor cells. Promotes differentiation of myogenic cells (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11782431
         
    Find genes that share ontologies with CDON           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdon):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size/body  limbs/digits/tail  mortality/aging  nervous system 
     respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with CDON           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDON: Cdontm1Aok Cdontm1Rsk

       genOway: Develop your customized and physiologically relevant rodent model for CDON

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDON:
    hsa-mir-96-5p (MIRT027875), hsa-mir-192-5p (MIRT026933), hsa-mir-124-3p (MIRT023201), hsa-mir-335-5p (MIRT019131), hsa-mir-34a-5p (MIRT025580)

    Block miRNA regulation of human, mouse, rat CDON using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDON (see all 71):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-146a hsa-miR-200a hsa-miR-3138 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDON 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDON
    Predesigned siRNA for gene silencing in human, mouse, rat CDON

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CDON

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    OriGene ORF clones in mouse, rat for CDON
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    GenScript: all cDNA clones in your preferred vector: CDON (NM_016952)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDON
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDON

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDON 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDON


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDON_HUMAN, Q4KMG0: Cell membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031012colocalizes with extracellular matrix TAS--

    Find genes that share ontologies with CDON           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDON About    
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family


    Find genes that share SuperPaths with CDON           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CDON
        Signaling events mediated by the Hedgehog family


    1 Reactome Pathway for CDON
        CDO in myogenesis


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDON: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDON

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for CDON (Q4KMG01, 2, 3 ENSP000002635774) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-7016840,EBI-375543 MINT-7221388 MINT-7221365 I2D: score=2 STRING: ENSP00000361423
    BOCQ9BWV13, ENSP000003475464I2D: score=2 STRING: ENSP00000347546
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CDH15P552913, ENSP000002897464I2D: score=1 STRING: ENSP00000289746
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001708cell fate specification IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0002088lens development in camera-type eye IEA--
    GO:0007155cell adhesion TAS9214393
    GO:0007224smoothened signaling pathway IEA--

    Find genes that share ontologies with CDON           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDON



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDON gene (2 alternative transcripts): 
    NM_001243597.1  NM_016952.4  

    Unigene Cluster for CDON:

    Cell adhesion associated, oncogene regulated
    Hs.38034  [show with all ESTs]
    Unigene Representative Sequence: NM_001243597
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392693(uc001qdb.4 uc009zbw.3 uc001qdc.4) ENST00000531738
    ENST00000263577 ENST00000534661(uc001qdd.4) ENST00000531830 ENST00000525625(uc009zbx.3)
    ENST00000531586 ENST00000527967 ENST00000534818
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDON using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDON (see all 71):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-146a hsa-miR-200a hsa-miR-3138 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDON 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDON
    Clone
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    OriGene clones in human, mouse for CDON (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDON (NM_016952)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDON
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDON
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CDON
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDON
      QuantiTect SYBR Green Assays in human, mouse, rat CDON
      QuantiFast Probe-based Assays in human, mouse, rat CDON

    Additional mRNA sequence: 

    AB209396.1 AF004841.2 AF086259.1 AK022986.1 AK309694.1 BC098583.1 BC112362.1 BC114435.1 

    4 DOTS entries:

    DT.40122115  DT.95130287  DT.120717624  DT.40130993 

    17 AceView cDNA sequences:

    NM_016952 AA435888 BX492188 BV179989 AA398836 BV180409 AF004841 CA407337 
    CA406818 BG924472 BX282476 BQ694971 BE542045 BX647207 CF594141 AL832223 
    BE154333 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDON    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
    SP1:        -                                                           -                                                                 -               
    SP2:        -                                                           -                                                                                 
    SP3:                                                                                                                                      -               
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for CDON

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDON expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGTATCA
    CDON Expression
    About this image


    CDON expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Limb (Muscoskeletal System)
             Autopod
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
     
     Heart (Cardiovascular System)
    CDON Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDON Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38034
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDON: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDON
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDON
    QuantiTect SYBR Green Assays in human, mouse, rat CDON
    QuantiFast Probe-based Assays in human, mouse, rat CDON
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDON

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDON gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdon1 , 5 cell adhesion molecule-related/down-regulated by oncogenes1, 5 82.43(n)1
    82.48(a)1
      9 (20.24 cM)5
    578101  NM_021339.21  NP_067314.21 
     354211285 
    chicken
    (Gallus gallus)
    Aves CDON6
    cell adhesion associated, oncogene regulated
    62(a)
    1 ↔ 1
    24(322587-362342) ENSGALG00000000939
    lizard
    (Anolis carolinensis)
    Reptilia CDON6
    cell adhesion associated, oncogene regulated
    62(a)
    1 ↔ 1
    GL343322.1(301048-324114)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdon-A2 cell adhesion molecule-related/down-regulated by oncogenes 75.28(n)    AF388035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10c022 wufa10c02 76.7(n)   334938  CA408053.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ihog6
    boi6
    (see all 3)
    brother of ihog
    (see all 3)
    20(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(6945464-6948808)
    X(2338200-2364036)


    ENSEMBL Gene Tree for CDON (if available)
    TreeFam Gene Tree for CDON (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDON gene
    BOC2  
    7 SIMAP similar genes for CDON using alignment to 7 protein entries:     CDON_HUMAN (see all proteins):
    MUSK    BOC    FGFR3    DCC    OBSCN    HMCN2
    TTN

    Find genes that share paralogs with CDON           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CDON (see all 13)
    PGOHUM00000257813 PGOHUM00000242410 PGOHUM00000242411 PGOHUM00000257903 PGOHUM00000257904


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDON (see all 2510)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459834701,2,,4
    C,FHoloprosencephaly 11 (HPE11)4 --125738149(+) CCTGGG/CTGTTT 4 /T /S mis12Minor allele frequency- C:0.01NA EU 5875
    VAR_0665014
    Holoprosencephaly 11 (HPE11)4--see VAR_0665012 T A mis40--------
    VAR_0664984
    Holoprosencephaly 11 (HPE11)4--see VAR_0664982 P A mis40--------
    VAR_0665024
    Holoprosencephaly 11 (HPE11)4--see VAR_0665022 S R mis40--------
    VAR_0665004
    Holoprosencephaly 11 (HPE11)4--see VAR_0665002 V E mis40--------
    VAR_0664994
    Holoprosencephaly 11 (HPE11)4--see VAR_0664992 V M mis40--------
    rs1412214341,2
    Cuntested1125753457(+) TTTCCA/C/GGAGTC 4 S syn10--------
    rs358289391,2
    C--121784888(+) TTTTT-/TTTTTT 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1430146171,2
    C--121786210(+) CATTT-/GTA   
       GGTAG
    GTAGG
    2 -- int10--------
    rs1123453521,2
    C--121786231(+) GTAGGA/TAGGTA 2 -- int11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for CDON (125825691 - 125933230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDON:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819513CNV Loss19587683
    nsv535CNV Loss18451855
    esv32964CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): CDON
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDON
    DNA2.0 Custom Variant and Variant Library Synthesis for CDON

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608707   
    OMIM disorders: 614226  
    UniProtKB/Swiss-Prot: CDON_HUMAN, Q4KMG0
  • Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing
    forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically
    heterogeneous and associated with several distinct facies and phenotypic variability. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 9 diseases for CDON:    
    About MalaCards
    holoprosencephaly 11    cdon-related holoprosencephaly    septopreoptic holoprosencephaly    midline interhemispheric variant of holoprosencephaly
    alobar holoprosencephaly    lobar holoprosencephaly    single median maxillary central incisor    semilobar holoprosencephaly
    holoprosencephaly

    1 disease from the University of Copenhagen DISEASES database for CDON:
    Holoprosencephaly

    Find genes that share disorders with CDON           About GenesLikeMe

    Genetic Association Database (GAD): CDON
    Human Genome Epidemiology (HuGE) Navigator: CDON (1 document)

    Export disorders for CDON gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDON gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with CDON)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PubMed id 9214393)1, 2, 3, 9 Kang J.-S....Krauss R.S. (J. Cell Biol. 1997)
    2. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. (PubMed id 21802063)1, 2 Bae G.U....Krauss R.S. (Am. J. Hum. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PubMed id 20519495)1, 2 Kavran J.M....Leahy D.J. (J. Biol. Chem. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PubMed id 12634428)1, 9 Kang J.-S.... Krauss R.S. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. (PubMed id 12720294)1, 9 Wegorzewska M....Kang J.S. (Mol. Carcinog. 2003)
    8. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. (PubMed id 23704328)1 Fatemifar G....Evans D.M. (Hum. Mol. Genet. 2013)
    9. Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication. (PubMed id 22326621)1 Sanchez-Arrones L....Bovolenta P. (amp 2012)
    10. Genetic variants associated with breast size also influence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (BMC Med. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50937 HGNC: 17104 AceView: CDON Ensembl:ENSG00000064309 euGenes: HUgn50937
    ECgene: CDON H-InvDB: CDON

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDON Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDON Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDON gene:
    Search GeneIP for patents involving CDON

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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