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CDO1 Gene

protein-coding   GIFtS: 63
GCID: GC05M115140

Cysteine Dioxygenase Type 1

(Previous names: cysteine dioxygenase, type I)
  See CDO1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine Dioxygenase Type 11 2
Cysteine Dioxygenase, Type I1 2
CDO2 3
CDO-I2 3
EC 1.13.11.203 8
Cysteine Dioxygenase Type I3

External Ids:    HGNC: 17951   Entrez Gene: 10362   Ensembl: ENSG000001295967   OMIM: 6039435   UniProtKB: Q168783   

Export aliases for CDO1 gene to outside databases

Previous GC identifers: GC05M114908 GC05M115547 GC05M115171 GC05M115216 GC05M115168 GC05M110321


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDO1 Gene:
CDO1 (cysteine dioxygenase type 1) is a protein-coding gene. Diseases associated with CDO1 include hepatoblastoma. GO annotations related to this gene include ferrous iron binding and cysteine dioxygenase activity.

UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
Function: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds
including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an
important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow
range




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDO1 gene promoter:
         POU2F2 (Oct-2.1)   oct-B3   oct-B2   FOXD1   POU2F2   Evi-1   POU2F1   POU2F1a   c-Myb   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDO1 promoter sequence
   Search Chromatin IP Primers for CDO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q23.2

CDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDO1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M115140:  view genomic region     (about GC identifiers)

Start:
115,140,430 bp from pter      End:
115,152,651 bp from pter
Size:
12,222 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878 (See protein sequence)
Recommended Name: Cysteine dioxygenase type 1  
Size: 200 amino acids; 22972 Da
Cofactor: Binds 1 iron ion per subunit. Zinc to a much lesser extent
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for CDO1:
2IC1 (3D)    
Secondary accessions: B2RAK4 P78513 Q6FHZ8 Q8TB64

Explore the universe of human proteins at neXtProt for CDO1: NX_Q16878

Explore proteomics data for CDO1 at MOPED

Post-translational modifications: 

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion,
    and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl
    hydrogen1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDO1 (Q16878) (see all 6)
     FDQRTGH  YTRNLVD  TFHSKFG  NLMILCWG 


    See CDO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001792.2  
    ENSEMBL proteins: 
     ENSP00000250535  
    Reactome Protein details: Q16878

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    Cloud-Clone Corp. Proteins for CDO1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011051 RmlC_Cupin
     IPR010300 Cys_dOase_I
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q16878

    ProtoNet protein and cluster: Q16878

    1 Blocks protein domain: IPB010300 Cysteine dioxygenase type I

    UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Similarity: Belongs to the cysteine dioxygenase family


    Find genes that share domains with CDO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDO1_HUMAN, Q16878
    Function: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds
    including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an
    important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow
    range
    Catalytic activity: L-cysteine + O(2) = 3-sulfinoalanine
    Induction: In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for CDO1:
    cysteine dioxygenase-1,cytosolic,expressed in liver

         Enzyme Number (IUBMB): EC 1.13.11.201 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding ----
    GO:0008198ferrous iron binding IEA--
    GO:0017172cysteine dioxygenase activity TAS--
    GO:0047800cysteamine dioxygenase activity ----
         
    Find genes that share ontologies with CDO1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDO1:
     Increased G1 DNA content  Increased HPV18 LCR reporter a 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdo1):
     behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging  reproductive system 
     respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with CDO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdo1tm1.1Mhst for CDO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDO1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDO1

    miRNA
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    miRTarBase miRNAs that target CDO1:
    hsa-mir-124-3p (MIRT022885)

    Block miRNA regulation of human, mouse, rat CDO1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CDO1:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidCDO1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for CDO1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS12110289

    Find genes that share ontologies with CDO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDO1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Degradation of cysteine and homocysteine0.00
    Cysteine and methionine metabolism0.35
    taurine biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of methionine degradation
    superpathway of methionine degradation
    L-cysteine degradation I0.00
    4Transcription CREB pathway
    Transcription CREB pathway0.34
    5Taurine and hypotaurine metabolism
    Taurine and hypotaurine metabolism0.31


    Find genes that share SuperPaths with CDO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CDO1
        Transcription CREB pathway

    3 BioSystems Pathways for CDO1
        taurine biosynthesis
    superpathway of methionine degradation
    L-cysteine degradation I


    1 Reactome Pathway for CDO1
        Degradation of cysteine and homocysteine


    3 Kegg Pathways  (Kegg details for CDO1):
        Cysteine and methionine metabolism
    Taurine and hypotaurine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDO1: 

              Amino Acid Metabolism I in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for CDO1 (Q168783 ENSP000002505354) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    MAPK14Q165393I2D: score=1 
    SPAG9O602713I2D: score=1 
    CSADENSP000002670854STRING: ENSP00000267085
    CTHENSP000003599764STRING: ENSP00000359976
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000097sulfur amino acid biosynthetic process TAS12110289
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0006534cysteine metabolic process TAS12110289
    GO:0006954inflammatory response TAS12110289

    Find genes that share ontologies with CDO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDO1

    5 HMDB Compounds for CDO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Sulfinoalanine3-Sulphino-L-alanine (see all 9)1115-65-7--
    IronArmco iron (see all 19)7439-89-6--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--

    2 DrugBank Compounds for CDO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17135237 16492780 16355974 17657274
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for CDO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine sulfinic acid 93.1 8 18308719 (1), 10936171 (1), 19011731 (1), 11008216 (1) (see all 7)
    taurine 76.4 16 12871209 (3), 10936171 (2), 14553911 (1), 11008216 (1) (see all 7)
    cysteine 73.9 73 14644768 (5), 17327371 (4), 19011731 (3), 11101006 (3) (see all 22)
    sulfate 47.8 4 18308719 (1), 11101006 (1), 14514920 (1)
    oligonucleotide 15.2 3 8835096 (1), 14514920 (1)



    Find genes that share compounds with CDO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDO1 gene: 
    NM_001801.2  

    Unigene Cluster for CDO1:

    Cysteine dioxygenase, type I
    Hs.442378  [show with all ESTs]
    Unigene Representative Sequence: NM_001801
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250535(uc003krg.3) ENST00000502631 ENST00000504877 ENST00000504613

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    hsa-miR-607
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK130357.1 AK314231.1 BC024241.2 CR536540.1 D85777.1 Z23010.1 Z31357.1 

    9 DOTS entries:

    DT.216274  DT.100693226  DT.101978494  DT.100798407  DT.100798408  DT.100737449  DT.101957002  DT.91718020 
    DT.92427054 

    Selected AceView cDNA sequences (see all 179):

    CR606190 AI684890 R93062 AA497033 BG565556 BI770353 AU117783 CR536540 
    BQ181453 BQ637817 N39918 AI357339 CR607883 AI937866 CR598067 D85777 
    CA397470 BG190603 BX503343 BX399040 AI744535 BQ004854 AA661846 AI049893 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDO1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:              -     -                                                         
    SP2:                    -                             -                           
    SP3:                                -                 -                           
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for CDO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATAGTCA
    CDO1 Expression
    About this image


    CDO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cushion Mesenchymal Cells Endocardium
             Heart Tube
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    CDO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442378

    UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also
    detected in hepatoblastoma Hep-G2 cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDO1: 
              Amino Acid Metabolism I in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDO1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdo11 , 5 cysteine dioxygenase 1, cytosolic1, 5 87.33(n)1
    92(a)1
      18 (24.75 cM)5
    125831  NM_033037.31  NP_149026.11 
     467132055 
    chicken
    (Gallus gallus)
    Aves CDO11 cysteine dioxygenase, type I 75.25(n)
    78.79(a)
      427391  XM_424964.3  XP_424964.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDO16
    cysteine dioxygenase type 1
    76(a)
    1 ↔ 1
    GL343193.1(8359708-8377266)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686562 hypothetical protein MGC68656 77.32(n)    BC060414.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731812 hypothetical protein MGC73181 74.28(n)   393714  BC059531.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54931 , 3 cysteine dioxygenase3
    CG54931
    52(a)3
    59.18(n)1
    57.3(a)1
      55E23
    371391  NM_001259481.11  NP_001246410.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F56F10.33
    cdo-11
    cytenine dioxygenase3
    cdo-11
    50(a)3
    56.44(n)1
    50(a)1
      X(897348-899507)3
    1804341  NM_075767.31  NP_508168.11 


    ENSEMBL Gene Tree for CDO1 (if available)
    TreeFam Gene Tree for CDO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDO1 gene
    1 SIMAP similar gene for CDO1 using alignment to 1 protein entry:     CDO1_HUMAN:
    CDO-1

    Find genes that share paralogs with CDO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDO1 (see all 333)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361704
    A colorectal cancer sample4--see VAR_0361702 E Q mis40--------
    rs1441171221,2
    --115139947(+) CACTTC/TGGGAG 1 -- int10--------
    rs1164069771,2
    C,F--115139984(+) GGAGAT/CCGAGA 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1486993021,2
    --115139986(+) AGATCA/GAGACC 1 -- int10--------
    rs1382522191,2
    C--115140011(+) CCCCG-/TCTCTAC 1 -- int10--------
    rs1422278381,2
    C--115140143(+) ACCCCA/GTCTCT 1 -- int10--------
    rs1843217151,2
    C--115140215(+) GAGGCC/TGAGGC 1 -- int10--------
    rs1900354821,2
    C--115140264(+) GAGCCA/GAGATT 1 -- int10--------
    rs357578541,2
    C--115140315(+) AAAAA-/ACCATT 1 -- int12Minor allele frequency- A:0.25NA 4
    rs100627581,2
    C--115140317(+) ctcaaC/Aaaaaa 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for CDO1 (115140430 - 115152651 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDO1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDO1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603943    OMIM disorders: --

    1 disease for CDO1:    
    About MalaCards
    hepatoblastoma


    Find genes that share disorders with CDO1           About GenesLikeMe

    3 Novoseek inferred disease relationships for CDO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 54.4 2 10427686 (1), 12871209 (1)
    necrosis 0 2 11101006 (1)
    tumors 0 2 11101006 (1)


    Export disorders for CDO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDO1 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with CDO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PubMed id 7524679)1, 2, 3, 9 McCann K.P.... Ramsden D.B. (Biochim. Biophys. Acta 1994)
    2. Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. (PubMed id 9497919)1, 2, 9 Ramsden D.B....Williams A.C. (Mol. Pathol. 1997)
    3. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. (PubMed id 17135237)2, 7 Ye S.... Rao Z. (J. Biol. Chem. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Development of an in vitro model for cysteine dioxygenase expression in the brain. (PubMed id 11101006)1, 9 Qusti S....Ramsden D.B. (Cell Biol. Toxicol. 2000)
    6. Human cysteine dioxygenase gene: structural organization, tissue- specific expression and downregulation by phorbol 12-myristate 13- acetate. (PubMed id 10427686)2, 9 Tsuboyama-Kasaoka N....Totani M. (Biosci. Biotechnol. Biochem. 1999)
    7. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. (PubMed id 17327371)1, 9 Dominy J.E....Stipanuk M.H. (Am. J. Physiol. Endocrinol. Metab. 2007)
    8. Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells. (PubMed id 12871209)1, 9 Satsu H....Shimizu M. (Biochem. J. 2003)
    9. Why do cysteine dioxygenase enzymes contain a 3-His ligand motif rather than a 2His/1Asp motif like most nonheme dioxygenases? (PubMed id 19199799)1, 9 de Visser S.P. and Straganz G.D. (J Phys Chem A 2009)
    10. Structure and mechanism of mouse cysteine dioxygenase. (PubMed id 16492780)7, 9 McCoy J.G....Phillips G.N. (Proc. Natl. Acad. Sci. U.S.A. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1036 HGNC: 1795 AceView: CDO1 Ensembl:ENSG00000129596 euGenes: HUgn1036
    ECgene: CDO1 Kegg: 1036 H-InvDB: CDO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDO1 gene:
    Search GeneIP for patents involving CDO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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