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Aliases for CDO1 Gene

Aliases for CDO1 Gene

  • Cysteine Dioxygenase Type 1 2 3
  • Cysteine Dioxygenase, Type I 2 3
  • EC 1.13.11.20 4 63
  • CDO-I 3 4
  • CDO 3 4
  • Cysteine Dioxygenase Type I 4

External Ids for CDO1 Gene

Previous GeneCards Identifiers for CDO1 Gene

  • GC05M114908
  • GC05M115547
  • GC05M115171
  • GC05M115216
  • GC05M115168
  • GC05M110321
  • GC05M115140

Summaries for CDO1 Gene

GeneCards Summary for CDO1 Gene

CDO1 (Cysteine Dioxygenase Type 1) is a Protein Coding gene. Diseases associated with CDO1 include hepatoblastoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ferrous iron binding and cysteine dioxygenase activity.

UniProtKB/Swiss-Prot for CDO1 Gene

  • Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDO1 Gene

Genomics for CDO1 Gene

Regulatory Elements for CDO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDO1 Gene

Start:
115,804,733 bp from pter
End:
115,816,954 bp from pter
Size:
12,222 bases
Orientation:
Minus strand

Genomic View for CDO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDO1 Gene

Proteins for CDO1 Gene

  • Protein details for CDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16878-CDO1_HUMAN
    Recommended name:
    Cysteine dioxygenase type 1
    Protein Accession:
    Q16878
    Secondary Accessions:
    • B2RAK4
    • P78513
    • Q6FHZ8
    • Q8TB64

    Protein attributes for CDO1 Gene

    Size:
    200 amino acids
    Molecular mass:
    22972 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) cation per subunit. Zn(2+) can be used to a much lesser extent.;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CDO1 Gene

neXtProt entry for CDO1 Gene

Proteomics data for CDO1 Gene at MOPED

Selected DME Specific Peptides for CDO1 Gene

Post-translational modifications for CDO1 Gene

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CDO1 Gene

Protein Domains for CDO1 Gene

Suggested Antigen Peptide Sequences for CDO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16878

UniProtKB/Swiss-Prot:

CDO1_HUMAN :
  • Q16878
Family:
  • Belongs to the cysteine dioxygenase family.
genes like me logo Genes that share domains with CDO1: view

No data available for Gene Families for CDO1 Gene

Function for CDO1 Gene

Molecular function for CDO1 Gene

GENATLAS Biochemistry: cysteine dioxygenase-1,cytosolic,expressed in liver
UniProtKB/Swiss-Prot CatalyticActivity: L-cysteine + O(2) = 3-sulfinoalanine
UniProtKB/Swiss-Prot Function: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range
UniProtKB/Swiss-Prot Induction: In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA).

Enzyme Numbers (IUBMB) for CDO1 Gene

Gene Ontology (GO) - Molecular Function for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding --
GO:0008198 ferrous iron binding IEA --
GO:0017172 cysteine dioxygenase activity TAS --
GO:0047800 cysteamine dioxygenase activity --
genes like me logo Genes that share ontologies with CDO1: view
genes like me logo Genes that share phenotypes with CDO1: view

Animal Models for CDO1 Gene

MGI Knock Outs for CDO1:

Animal Model Products

CRISPR Products

miRNA for CDO1 Gene

miRTarBase miRNAs that target CDO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDO1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CDO1 Gene

Localization for CDO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDO1 Gene COMPARTMENTS Subcellular localization image for CDO1 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 12110289
genes like me logo Genes that share ontologies with CDO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDO1 Gene

Pathways for CDO1 Gene

genes like me logo Genes that share pathways with CDO1: view

PCR Array Products

UniProtKB/Swiss-Prot Q16878-CDO1_HUMAN

  • Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2

Gene Ontology (GO) - Biological Process for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0000097 sulfur amino acid biosynthetic process TAS 12110289
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0006534 cysteine metabolic process TAS 12110289
GO:0006954 inflammatory response TAS 12110289
genes like me logo Genes that share ontologies with CDO1: view

Compounds for CDO1 Gene

(5) HMDB Compounds for CDO1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Sulfinoalanine
  • 3-Sulphino-L-alanine
1115-65-7
Iron
  • Armco iron
7439-89-6
L-Cysteine
  • (+)-2-Amino-3-mercaptopropionic acid
52-90-4
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
Oxygen
  • Oxygen
7782-44-7

(2) Drugbank Compounds for CDO1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Cysteine
  • (R)-2-Amino-3-mercaptopropanoic acid
52-90-4 target
NADH
  • beta-DPNH
606-68-8 target

(5) Novoseek inferred chemical compound relationships for CDO1 Gene

Compound -log(P) Hits PubMed IDs
cysteine sulfinic acid 93.1 7
taurine 76.4 10
cysteine 73.9 37
sulfate 47.8 3
oligonucleotide 15.2 2
genes like me logo Genes that share compounds with CDO1: view

Transcripts for CDO1 Gene

mRNA/cDNA for CDO1 Gene

Unigene Clusters for CDO1 Gene

Cysteine dioxygenase, type I:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CDO1 Gene

GeneLoc Exon Structure for
CDO1
ECgene alternative splicing isoforms for
CDO1

Expression for CDO1 Gene

mRNA expression in normal human tissues for CDO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDO1 Gene

This gene is overexpressed in Liver (10.6) and Nerve - Tibial (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDO1 Gene

SOURCE GeneReport for Unigene cluster for CDO1 Gene Hs.442378

mRNA Expression by UniProt/SwissProt for CDO1 Gene

Q16878-CDO1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
genes like me logo Genes that share expressions with CDO1: view

In Situ Assay Products

Orthologs for CDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDO1 35
  • 99.67 (n)
  • 100 (a)
CDO1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDO1 35
  • 91.33 (n)
  • 92.5 (a)
CDO1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDO1 35
  • 92.83 (n)
  • 94 (a)
CDO1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdo1 35
  • 87.33 (n)
  • 92 (a)
Cdo1 16
Cdo1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDO1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDO1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdo1 35
  • 88 (n)
  • 92 (a)
chicken
(Gallus gallus)
Aves CDO1 35
  • 75.25 (n)
  • 78.79 (a)
CDO1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDO1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68656 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdo1 35
  • 75.33 (n)
  • 79 (a)
MGC75851 35
zebrafish
(Danio rerio)
Actinopterygii zgc73181 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005153 35
  • 58.43 (n)
  • 59.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5493 35
  • 59.18 (n)
  • 57.3 (a)
CG5493 36
  • 43 (a)
OneToOne
CG5493 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea cdo-1 35
  • 56.44 (n)
  • 50 (a)
cdo-1 36
  • 47 (a)
OneToOne
F56F10.3 37
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06625 35
  • 52.61 (n)
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5694 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10917 36
  • 45 (a)
OneToOne
Species with no ortholog for CDO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDO1 Gene

ENSEMBL:
Gene Tree for CDO1 (if available)
TreeFam:
Gene Tree for CDO1 (if available)

Paralogs for CDO1 Gene

Selected SIMAP similar genes for CDO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDO1: view

No data available for Paralogs for CDO1 Gene

Variants for CDO1 Gene

Sequence variations from dbSNP and Humsavar for CDO1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs12782 -- 115,816,552(-) ACATC(C/T)TTACG utr-variant-5-prime, nc-transcript-variant
rs26531 -- 115,814,828(-) GAAGA(A/C)GTTGA intron-variant
rs34850 -- 115,807,048(+) GCAGA(C/G)TAAGG intron-variant
rs34869 -- 115,816,997(-) GCCAT(C/G)TCCTC upstream-variant-2KB
rs154757 -- 115,812,961(+) AGAAT(C/T)GCTTG intron-variant

Relevant External Links for CDO1 Gene

HapMap Linkage Disequilibrium report
CDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDO1 Gene

Disorders for CDO1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDO1 Gene including...

Search for CDO1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for CDO1 Gene

Disease -log(P) Hits PubMed IDs
hepatoblastoma 54.4 2
necrosis 0 1
tumors 0 1
genes like me logo Genes that share disorders with CDO1: view

No data available for UniProtKB/Swiss-Prot for CDO1 Gene

Publications for CDO1 Gene

  1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PMID: 7524679) McCann K.P. … Ramsden D.B. (Biochim. Biophys. Acta 1994) 2 3 4 23
  2. Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. (PMID: 9497919) Ramsden D.B. … Williams A.C. (Mol. Pathol. 1997) 3 4 23
  3. Human cysteine dioxygenase gene: structural organization, tissue- specific expression and downregulation by phorbol 12-myristate 13- acetate. (PMID: 10427686) Tsuboyama-Kasaoka N. … Totani M. (Biosci. Biotechnol. Biochem. 1999) 4 23
  4. Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase. (PMID: 8835096) Jeremiah S. … Povey S. (Ann. Hum. Genet. 1996) 3 23
  5. Development of an in vitro model for cysteine dioxygenase expression in the brain. (PMID: 11101006) Qusti S. … Ramsden D.B. (Cell Biol. Toxicol. 2000) 3 23

Products for CDO1 Gene

Sources for CDO1 Gene

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