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Aliases for CDO1 Gene

Aliases for CDO1 Gene

  • Cysteine Dioxygenase Type 1 2 3 5
  • Cysteine Dioxygenase, Type I 2 3
  • EC 1.13.11.20 4 63
  • CDO-I 3 4
  • Cysteine Dioxygenase Type I 4
  • CDO 4

External Ids for CDO1 Gene

Previous GeneCards Identifiers for CDO1 Gene

  • GC05M114908
  • GC05M115547
  • GC05M115171
  • GC05M115216
  • GC05M115168
  • GC05M110321
  • GC05M115140

Summaries for CDO1 Gene

GeneCards Summary for CDO1 Gene

CDO1 (Cysteine Dioxygenase Type 1) is a Protein Coding gene. Diseases associated with CDO1 include Holoprosencephaly 11 and Hepatoblastoma. Among its related pathways are Taurine and hypotaurine metabolism and superpathway of methionine degradation. GO annotations related to this gene include iron ion binding and cysteamine dioxygenase activity.

UniProtKB/Swiss-Prot for CDO1 Gene

  • Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDO1 Gene

Genomics for CDO1 Gene

Regulatory Elements for CDO1 Gene

Enhancers for CDO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDO1 on UCSC Golden Path with GeneCards custom track

Promoters for CDO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDO1 Gene

Chromosome:
5
Start:
115,804,733 bp from pter
End:
115,816,954 bp from pter
Size:
12,222 bases
Orientation:
Minus strand

Genomic View for CDO1 Gene

Genes around CDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDO1 Gene

Proteins for CDO1 Gene

  • Protein details for CDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16878-CDO1_HUMAN
    Recommended name:
    Cysteine dioxygenase type 1
    Protein Accession:
    Q16878
    Secondary Accessions:
    • B2RAK4
    • P78513
    • Q6FHZ8
    • Q8TB64

    Protein attributes for CDO1 Gene

    Size:
    200 amino acids
    Molecular mass:
    22972 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CDO1 Gene

neXtProt entry for CDO1 Gene

Proteomics data for CDO1 Gene at MOPED

Selected DME Specific Peptides for CDO1 Gene

Post-translational modifications for CDO1 Gene

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDO1 Gene

Antibody Products

Domains & Families for CDO1 Gene

Protein Domains for CDO1 Gene

Suggested Antigen Peptide Sequences for CDO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16878

UniProtKB/Swiss-Prot:

CDO1_HUMAN :
  • Belongs to the cysteine dioxygenase family.
Family:
  • Belongs to the cysteine dioxygenase family.
genes like me logo Genes that share domains with CDO1: view

No data available for Gene Families for CDO1 Gene

Function for CDO1 Gene

Molecular function for CDO1 Gene

GENATLAS Biochemistry:
cysteine dioxygenase-1,cytosolic,expressed in liver
UniProtKB/Swiss-Prot CatalyticActivity:
L-cysteine + O(2) = 3-sulfinoalanine.
UniProtKB/Swiss-Prot Function:
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
UniProtKB/Swiss-Prot Induction:
In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA).

Enzyme Numbers (IUBMB) for CDO1 Gene

Gene Ontology (GO) - Molecular Function for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008198 ferrous iron binding IEA --
genes like me logo Genes that share ontologies with CDO1: view
genes like me logo Genes that share phenotypes with CDO1: view

Animal Models for CDO1 Gene

MGI Knock Outs for CDO1:

Animal Model Products

miRNA for CDO1 Gene

miRTarBase miRNAs that target CDO1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDO1 Gene

Localization for CDO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDO1 Gene COMPARTMENTS Subcellular localization image for CDO1 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDO1 Gene

Pathways & Interactions for CDO1 Gene

genes like me logo Genes that share pathways with CDO1: view

UniProtKB/Swiss-Prot Q16878-CDO1_HUMAN

  • Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

SIGNOR curated interactions for CDO1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000097 sulfur amino acid biosynthetic process TAS 12110289
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0006534 cysteine metabolic process TAS 12110289
GO:0006954 inflammatory response TAS 12110289
GO:0007595 lactation IEA --
genes like me logo Genes that share ontologies with CDO1: view

Drugs & Compounds for CDO1 Gene

(5) Drugs for CDO1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Cysteine Approved Nutra Target 0
3-Sulfinoalanine Experimental Pharma 0
NADH Nutra Target 0

(6) Additional Compounds for CDO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with CDO1: view

Transcripts for CDO1 Gene

Unigene Clusters for CDO1 Gene

Cysteine dioxygenase, type I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CDO1 Gene

GeneLoc Exon Structure for
CDO1
ECgene alternative splicing isoforms for
CDO1

Expression for CDO1 Gene

mRNA expression in normal human tissues for CDO1 Gene

mRNA differential expression in normal tissues according to GTEx for CDO1 Gene

This gene is overexpressed in Liver (x10.6) and Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for CDO1 Gene

This gene is overexpressed in Breast (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDO1 Gene



SOURCE GeneReport for Unigene cluster for CDO1 Gene Hs.442378

mRNA Expression by UniProt/SwissProt for CDO1 Gene

Q16878-CDO1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
genes like me logo Genes that share expression patterns with CDO1: view

Protein tissue co-expression partners for CDO1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDO1 Gene

Orthologs for CDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDO1 35
  • 91.33 (n)
  • 92.5 (a)
CDO1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDO1 35
  • 92.83 (n)
  • 94 (a)
CDO1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdo1 35
  • 87.33 (n)
  • 92 (a)
Cdo1 16
Cdo1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDO1 35
  • 99.67 (n)
  • 100 (a)
CDO1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdo1 35
  • 88 (n)
  • 92 (a)
oppossum
(Monodelphis domestica)
Mammalia CDO1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDO1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDO1 35
  • 75.25 (n)
  • 78.79 (a)
CDO1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDO1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdo1 35
  • 75.33 (n)
  • 79 (a)
MGC75851 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68656 35
zebrafish
(Danio rerio)
Actinopterygii zgc73181 35
fruit fly
(Drosophila melanogaster)
Insecta CG5493 37
  • 52 (a)
CG5493 35
  • 59.18 (n)
  • 57.3 (a)
CG5493 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005153 35
  • 58.43 (n)
  • 59.55 (a)
worm
(Caenorhabditis elegans)
Secernentea F56F10.3 37
  • 50 (a)
cdo-1 35
  • 56.44 (n)
  • 50 (a)
cdo-1 36
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5694 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06625 35
  • 52.61 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10917 36
  • 45 (a)
OneToOne
Species with no ortholog for CDO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDO1 Gene

ENSEMBL:
Gene Tree for CDO1 (if available)
TreeFam:
Gene Tree for CDO1 (if available)

Paralogs for CDO1 Gene

(1) SIMAP similar genes for CDO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDO1: view

No data available for Paralogs for CDO1 Gene

Variants for CDO1 Gene

Sequence variations from dbSNP and Humsavar for CDO1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_023536 -
VAR_036170 A colorectal cancer sample
rs718584 -- 115,805,024(-) ATGTA(G/T)ATGTC downstream-variant-500B, utr-variant-3-prime
rs34850 -- 115,807,048(+) GCAGA(C/G)TAAGG intron-variant
rs154757 -- 115,812,961(+) AGAAT(C/T)GCTTG intron-variant

Variation tolerance for CDO1 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDO1 Gene

Human Gene Mutation Database (HGMD)
CDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDO1 Gene

Disorders for CDO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDO1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
holoprosencephaly 11
  • holoprosencephaly-11
hepatoblastoma
  • hbl
- elite association - COSMIC cancer census association via MalaCards
Search CDO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDO1
genes like me logo Genes that share disorders with CDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDO1 Gene

Publications for CDO1 Gene

  1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PMID: 7524679) McCann K.P. … Ramsden D.B. (Biochim. Biophys. Acta 1994) 2 3 4 23 67
  2. Structure and mechanism of mouse cysteine dioxygenase. (PMID: 16492780) McCoy J.G. … Phillips G.N. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 25 26
  3. Why do cysteine dioxygenase enzymes contain a 3-His ligand motif rather than a 2His/1Asp motif like most nonheme dioxygenases? (PMID: 19199799) de Visser S.P. … Straganz G.D. (J Phys Chem A 2009) 3 23
  4. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. (PMID: 17327371) Dominy J.E. … Stipanuk M.H. (Am. J. Physiol. Endocrinol. Metab. 2007) 3 23
  5. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. (PMID: 17135237) Ye S. … Rao Z. (J. Biol. Chem. 2007) 25 26

Products for CDO1 Gene

Sources for CDO1 Gene

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