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Aliases for CDO1 Gene

Aliases for CDO1 Gene

  • Cysteine Dioxygenase Type 1 2 3 5
  • Cysteine Dioxygenase, Type I 2 3
  • EC 1.13.11.20 4 58
  • CDO-I 3 4
  • Cysteine Dioxygenase Type I 4
  • CDO 4

External Ids for CDO1 Gene

Previous GeneCards Identifiers for CDO1 Gene

  • GC05M114908
  • GC05M115547
  • GC05M115171
  • GC05M115216
  • GC05M115168
  • GC05M110321
  • GC05M115140

Summaries for CDO1 Gene

GeneCards Summary for CDO1 Gene

CDO1 (Cysteine Dioxygenase Type 1) is a Protein Coding gene. Diseases associated with CDO1 include Hepatoblastoma and Esophagus Adenocarcinoma. Among its related pathways are Metabolism and Sulfur amino acid metabolism. GO annotations related to this gene include iron ion binding and cysteamine dioxygenase activity.

UniProtKB/Swiss-Prot for CDO1 Gene

  • Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

Additional gene information for CDO1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDO1 Gene

Genomics for CDO1 Gene

Regulatory Elements for CDO1 Gene

Enhancers for CDO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H115838 1.2 ENCODE 34.4 -25.2 -25173 6 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 CDO1 ATG12 PGGT1B GC05M115886
GH05H115815 0.9 ENCODE 33.1 +0.4 430 1 TBP ZSCAN4 ZNF76 ZNF2 RAD21 YY1 GLIS2 ZNF391 EGR2 SP3 CDO1 ATG12 PGGT1B GC05M115775 RNU2-49P
GH05H115806 0.5 ENCODE 30.2 +10.0 9961 1 GATA3 BCL6 DPF2 PRDM1 CDO1 RNU2-49P ENSG00000251118 ATG12 AP3S1 TMED7 TMED7-TICAM2 GC05M115775
GH05H115734 0.7 FANTOM5 12.9 +81.8 81771 0 FOXA2 MAX REST RAD21 FOXA1 JUND ATF3 CEBPA HNF4G ZBTB33 CDO1 ENSG00000251118 RNU2-49P LVRN ENSG00000248709 ENSG00000249021
GH05H115856 1.1 Ensembl ENCODE 6.2 -40.4 -40388 2 PKNOX1 FOXA2 ARNT NFIB ZNF133 FEZF1 ZNF2 ZNF366 ZSCAN5C ZNF362 ENSG00000250015 ATG12 PGGT1B AP3S1 CDO1 GC05M115886
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDO1 on UCSC Golden Path with GeneCards custom track

Promoters for CDO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000185586 254 1000 TBP ZSCAN4 INSM2 ZNF76 ZNF2 RAD21 YY1 GLIS2 ZNF391 EGR2

Genomic Location for CDO1 Gene

Chromosome:
5
Start:
115,804,733 bp from pter
End:
115,816,954 bp from pter
Size:
12,222 bases
Orientation:
Minus strand

Genomic View for CDO1 Gene

Genes around CDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDO1 Gene

Proteins for CDO1 Gene

  • Protein details for CDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16878-CDO1_HUMAN
    Recommended name:
    Cysteine dioxygenase type 1
    Protein Accession:
    Q16878
    Secondary Accessions:
    • B2RAK4
    • P78513
    • Q6FHZ8
    • Q8TB64

    Protein attributes for CDO1 Gene

    Size:
    200 amino acids
    Molecular mass:
    22972 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CDO1 Gene

neXtProt entry for CDO1 Gene

Selected DME Specific Peptides for CDO1 Gene

Q16878:
  • LQGNLKETLF
  • FDQRTGH
  • NLMILCWG
  • TFHSKFG
  • ENQCAYINDS
  • YTRNLVD

Post-translational modifications for CDO1 Gene

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDO1 Gene

Domains & Families for CDO1 Gene

Gene Families for CDO1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDO1 Gene

Suggested Antigen Peptide Sequences for CDO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16878

UniProtKB/Swiss-Prot:

CDO1_HUMAN :
  • Belongs to the cysteine dioxygenase family.
Family:
  • Belongs to the cysteine dioxygenase family.
genes like me logo Genes that share domains with CDO1: view

Function for CDO1 Gene

Molecular function for CDO1 Gene

GENATLAS Biochemistry:
cysteine dioxygenase-1,cytosolic,expressed in liver
UniProtKB/Swiss-Prot CatalyticActivity:
L-cysteine + O(2) = 3-sulfinoalanine.
UniProtKB/Swiss-Prot Function:
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
UniProtKB/Swiss-Prot Induction:
In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA).

Enzyme Numbers (IUBMB) for CDO1 Gene

Phenotypes From GWAS Catalog for CDO1 Gene

Gene Ontology (GO) - Molecular Function for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008198 ferrous iron binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA --
GO:0017172 cysteine dioxygenase activity TAS --
genes like me logo Genes that share ontologies with CDO1: view
genes like me logo Genes that share phenotypes with CDO1: view

Animal Models for CDO1 Gene

MGI Knock Outs for CDO1:

Animal Model Products

CRISPR Products

miRNA for CDO1 Gene

miRTarBase miRNAs that target CDO1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDO1
  • Applied Biological Materials Clones for CDO1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDO1 Gene

Localization for CDO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDO1 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS,IEA 12110289
genes like me logo Genes that share ontologies with CDO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDO1 Gene

Pathways & Interactions for CDO1 Gene

genes like me logo Genes that share pathways with CDO1: view

UniProtKB/Swiss-Prot Q16878-CDO1_HUMAN

  • Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

SIGNOR curated interactions for CDO1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000097 sulfur amino acid biosynthetic process TAS 12110289
GO:0006534 cysteine metabolic process TAS 12110289
GO:0006954 inflammatory response TAS 12110289
GO:0007595 lactation IEA --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with CDO1: view

Drugs & Compounds for CDO1 Gene

(6) Drugs for CDO1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Cysteine Approved Nutra Target 0
Oxygen Approved, Vet_approved Pharma 0
3-Sulfinoalanine Experimental Pharma 0
NADH Nutra Target 0

(5) Additional Compounds for CDO1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with CDO1: view

Transcripts for CDO1 Gene

Unigene Clusters for CDO1 Gene

Cysteine dioxygenase, type I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDO1
  • Applied Biological Materials Clones for CDO1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CDO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CDO1 Gene

GeneLoc Exon Structure for
CDO1
ECgene alternative splicing isoforms for
CDO1

Expression for CDO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDO1 Gene

mRNA differential expression in normal tissues according to GTEx for CDO1 Gene

This gene is overexpressed in Liver (x10.6) and Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for CDO1 Gene

This gene is overexpressed in Breast (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDO1 Gene



Protein tissue co-expression partners for CDO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDO1 Gene:

CDO1

SOURCE GeneReport for Unigene cluster for CDO1 Gene:

Hs.442378

mRNA Expression by UniProt/SwissProt for CDO1 Gene:

Q16878-CDO1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.

Evidence on tissue expression from TISSUES for CDO1 Gene

  • Nervous system(4.8)
  • Liver(4.6)
genes like me logo Genes that share expression patterns with CDO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDO1 Gene

Orthologs for CDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDO1 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia CDO1 33 34
  • 92.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDO1 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDO1 33 34
  • 91.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CDO1 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdo1 33
  • 88 (n)
mouse
(Mus musculus)
Mammalia Cdo1 33 16 34
  • 87.33 (n)
chicken
(Gallus gallus)
Aves CDO1 33 34
  • 75.25 (n)
lizard
(Anolis carolinensis)
Reptilia CDO1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdo1 33
  • 75.33 (n)
MGC75851 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68656 33
zebrafish
(Danio rerio)
Actinopterygii zgc73181 33
fruit fly
(Drosophila melanogaster)
Insecta CG5493 35 33 34
  • 59.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005153 33
  • 58.43 (n)
worm
(Caenorhabditis elegans)
Secernentea cdo-1 33 34
  • 56.44 (n)
F56F10.3 35
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06625 33
  • 52.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10917 34
  • 45 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5694 33
Species where no ortholog for CDO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDO1 Gene

ENSEMBL:
Gene Tree for CDO1 (if available)
TreeFam:
Gene Tree for CDO1 (if available)

Paralogs for CDO1 Gene

(1) SIMAP similar genes for CDO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDO1: view

No data available for Paralogs for CDO1 Gene

Variants for CDO1 Gene

Sequence variations from dbSNP and Humsavar for CDO1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036170 A colorectal cancer sample
rs1000579373 -- 115,810,227(+) CCACA(C/T)AGGAA intron-variant
rs1000727074 -- 115,804,259(+) AGGCC(A/G)AGGCG downstream-variant-500B
rs1000858561 -- 115,815,378(+) CCAGG(G/T)CACCT intron-variant
rs1001042153 -- 115,809,133(+) GCAGG(C/T)CCACG intron-variant

Variation tolerance for CDO1 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDO1 Gene

Human Gene Mutation Database (HGMD)
CDO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDO1 Gene

Disorders for CDO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDO1 Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatoblastoma
  • hbl
esophagus adenocarcinoma
  • adenocarcinoma of esophagus
- elite association - COSMIC cancer census association via MalaCards
Search CDO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDO1
genes like me logo Genes that share disorders with CDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDO1 Gene

Publications for CDO1 Gene

  1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PMID: 7524679) McCann KP … Ramsden DB (Biochimica et biophysica acta 1994) 2 3 4 22 60
  2. Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. (PMID: 9497919) Ramsden DB … Williams AC (Molecular pathology : MP 1997) 3 4 22 60
  3. Why do cysteine dioxygenase enzymes contain a 3-His ligand motif rather than a 2His/1Asp motif like most nonheme dioxygenases? (PMID: 19199799) de Visser SP … Straganz GD (The journal of physical chemistry. A 2009) 3 22 60
  4. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. (PMID: 17327371) Dominy JE … Stipanuk MH (American journal of physiology. Endocrinology and metabolism 2007) 3 22 60
  5. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. (PMID: 17135237) Ye S … Rao Z (The Journal of biological chemistry 2007) 4 25 60

Products for CDO1 Gene

  • Addgene plasmids for CDO1

Sources for CDO1 Gene

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