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Aliases for CDNF Gene

Aliases for CDNF Gene

  • Cerebral Dopamine Neurotrophic Factor 2 3
  • Conserved Dopamine Neurotrophic Factor 2 3 4
  • Arginine-Rich, Mutated In Early Stage Tumors-Like 1 2 3
  • ARMET-Like Protein 1 3 4
  • ARMETL1 3 4
  • ARMETL1, 6

External Ids for CDNF Gene

Previous Symbols for CDNF Gene

  • ARMETL1

Summaries for CDNF Gene

GeneCards Summary for CDNF Gene

CDNF (Cerebral Dopamine Neurotrophic Factor) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.

UniProtKB/Swiss-Prot for CDNF Gene

  • Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDNF Gene

Genomics for CDNF Gene

Genomic Location for CDNF Gene

Start:
14,819,250 bp from pter
End:
14,838,575 bp from pter
Size:
19,326 bases
Orientation:
Minus strand

Genomic View for CDNF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDNF Gene

No data available for Regulatory Elements for CDNF Gene

Proteins for CDNF Gene

  • Protein details for CDNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AH0-CDNF_HUMAN
    Recommended name:
    Cerebral dopamine neurotrophic factor
    Protein Accession:
    Q49AH0
    Secondary Accessions:
    • A2RUU0
    • B4DVW3

    Protein attributes for CDNF Gene

    Size:
    187 amino acids
    Molecular mass:
    20964 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDNF Gene

    Alternative splice isoforms for CDNF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDNF Gene

Proteomics data for CDNF Gene at MOPED

Post-translational modifications for CDNF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDNF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDNF Gene

Domains for CDNF Gene

Protein Domains for CDNF Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CDNF_HUMAN
Family:
  • Belongs to the ARMET family.:
    • Q49AH0
genes like me logo Genes that share domains with CDNF: view

No data available for Gene Families for CDNF Gene

Function for CDNF Gene

Molecular function for CDNF Gene

UniProtKB/Swiss-Prot Function: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
UniProtKB/Swiss-Prot Induction: Not induced by endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CDNF: view

Phenotypes for CDNF Gene

GenomeRNAi human phenotypes for CDNF:
genes like me logo Genes that share phenotypes with CDNF: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDNF Gene

Localization for CDNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDNF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDNF Gene COMPARTMENTS Subcellular localization image for CDNF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CDNF: view

Pathways for CDNF Gene

SuperPathways for CDNF Gene

No Data Available

Interacting Proteins for CDNF Gene

Gene Ontology (GO) - Biological Process for CDNF Gene

None

No data available for Pathways by source for CDNF Gene

Transcripts for CDNF Gene

Unigene Clusters for CDNF Gene

Cerebral dopamine neurotrophic factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDNF Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for CDNF Gene

GeneLoc Exon Structure for
CDNF
ECgene alternative splicing isoforms for
CDNF

Expression for CDNF Gene

mRNA expression in normal human tissues for CDNF Gene

mRNA differential expression in normal tissues according to GTEx for CDNF Gene

This gene is overexpressed in Muscle - Skeletal (8.2) and Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CDNF Gene

SOURCE GeneReport for Unigene cluster for CDNF Gene Hs.559067

mRNA Expression by UniProt/SwissProt for CDNF Gene

Q49AH0-CDNF_HUMAN
Tissue specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
genes like me logo Genes that share expressions with CDNF: view

Orthologs for CDNF Gene

This gene was present in the common ancestor of animals.

Orthologs for CDNF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDNF 36
  • 99.29 (n)
  • 98.93 (a)
CDNF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDNF 36
  • 87.52 (n)
  • 87.7 (a)
CDNF 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDNF 36
  • 87.34 (n)
  • 87.7 (a)
CDNF 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdnf 36
  • 82.89 (n)
  • 77.54 (a)
Cdnf 16
Cdnf 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDNF 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDNF 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdnf 36
  • 82.71 (n)
  • 80.75 (a)
lizard
(Anolis carolinensis)
Reptilia CDNF 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdnf 36
  • 67.13 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii cdnf 36
  • 59.28 (n)
  • 53.69 (a)
cdnf 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Manf 37
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.23 37
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9334 37
  • 47 (a)
OneToMany
Species with no ortholog for CDNF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDNF Gene

ENSEMBL:
Gene Tree for CDNF (if available)
TreeFam:
Gene Tree for CDNF (if available)

Paralogs for CDNF Gene

Paralogs for CDNF Gene

Selected SIMAP similar genes for CDNF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDNF: view

Variants for CDNF Gene

Sequence variations from dbSNP and Humsavar for CDNF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1901650 -- 14,822,888(+) TAAAT(A/T)TTTAT intron-variant
rs2278871 -- 14,819,402(+) TTATA(C/T)GGTTT utr-variant-3-prime
rs2895609 -- 14,832,574(+) ttaga(A/G)gttct intron-variant
rs3740113 -- 14,828,387(+) CTTAC(C/G)CCTGT intron-variant
rs4598568 -- 14,823,754(+) actcc(A/T)gggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDNF Gene

Variant ID Type Subtype PubMed ID
nsv471664 CNV Gain+Loss 15918152
nsv5899 CNV Insertion 18451855

Relevant External Links for CDNF Gene

HapMap Linkage Disequilibrium report
CDNF

Disorders for CDNF Gene

(1) University of Copenhagen DISEASES for CDNF Gene

Relevant External Links for CDNF

Human Genome Epidemiology (HuGE) Navigator
CDNF
genes like me logo Genes that share disorders with CDNF: view

No data available for UniProtKB/Swiss-Prot for CDNF Gene

Publications for CDNF Gene

  1. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. (PMID: 17611540) Lindholm P. … Saarma M. (Nature 2007) 2 3 4
  2. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PMID: 19258449) Parkash V. … Goldman A. (Protein Eng. Des. Sel. 2009) 3 4
  3. Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. (PMID: 19429035) Lohoff F.W. … Oslin D.W. (Neurosci. Lett. 2009) 3
  4. Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. (PMID: 21320571) Choi J.M. … Kim Y.J. (Neurosci. Lett. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for CDNF Gene

Sources for CDNF Gene

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