Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDNF Gene

Aliases for CDNF Gene

  • Cerebral Dopamine Neurotrophic Factor 2 3 5
  • Conserved Dopamine Neurotrophic Factor 2 3 4
  • Arginine-Rich, Mutated In Early Stage Tumors-Like 1 2 3
  • ARMET-Like Protein 1 3 4
  • ARMETL1 3 4

External Ids for CDNF Gene

Previous HGNC Symbols for CDNF Gene

  • ARMETL1

Previous GeneCards Identifiers for CDNF Gene

  • GC10M014902
  • GC10M014861

Summaries for CDNF Gene

GeneCards Summary for CDNF Gene

CDNF (Cerebral Dopamine Neurotrophic Factor) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.

UniProtKB/Swiss-Prot for CDNF Gene

  • Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDNF Gene

Genomics for CDNF Gene

Regulatory Elements for CDNF Gene

Enhancers for CDNF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F014872 0.7 ENCODE 11.5 -34.7 -34729 1.2 ZNF664 MAZ MTA2 JUNB TBX21 ZBTB40 CDNF HSPA14 ENSG00000272853 LOC100421372
GH10F014542 0.9 Ensembl ENCODE 11.2 +295.0 295011 1.9 CTCF SAP130 NR2F1 RAD21 NR2F2 YY1 TEAD3 RARA POLR2A NR2F6 FAM107B CDNF HSPA14 GC10M014524 LOC105376429
GH10F014889 0.2 ENCODE 11.1 -51.0 -51002 0.2 CTCF CBX3 TAL1 ZNF644 CHAMP1 ZNF7 NCOR1 NR2F6 TRIM24 CREM CDNF HSPA14 GAPDHP45 C10orf111 RPP38 PIR33358 GC10M014904
GH10F014535 0.2 ENCODE 11.1 +302.3 302323 0.8 ELF3 ARID4B FEZF1 RAD21 YY1 HMG20B NFYC CEBPB PPARG KAT8 CDNF HSPA14 GC10M014524 LOC105376429
GH10F014537 0.5 ENCODE 11.1 +301.5 301479 0.2 CTCF SAP130 CEBPG RAD21 SMC3 CREM SOX5 ZNF654 HLF REST CDNF HSPA14 FAM107B GC10M014524 LOC105376429
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDNF on UCSC Golden Path with GeneCards custom track

Promoters for CDNF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001421291 75 3001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for CDNF Gene

Chromosome:
10
Start:
14,819,245 bp from pter
End:
14,838,575 bp from pter
Size:
19,331 bases
Orientation:
Minus strand

Genomic View for CDNF Gene

Genes around CDNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDNF Gene

Proteins for CDNF Gene

  • Protein details for CDNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AH0-CDNF_HUMAN
    Recommended name:
    Cerebral dopamine neurotrophic factor
    Protein Accession:
    Q49AH0
    Secondary Accessions:
    • A2RUU0
    • B4DVW3

    Protein attributes for CDNF Gene

    Size:
    187 amino acids
    Molecular mass:
    20964 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDNF Gene

    Alternative splice isoforms for CDNF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDNF Gene

Post-translational modifications for CDNF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDNF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDNF Gene

Domains & Families for CDNF Gene

Protein Domains for CDNF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDNF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AH0

UniProtKB/Swiss-Prot:

CDNF_HUMAN :
  • Belongs to the ARMET family.
Family:
  • Belongs to the ARMET family.
genes like me logo Genes that share domains with CDNF: view

No data available for Gene Families for CDNF Gene

Function for CDNF Gene

Molecular function for CDNF Gene

UniProtKB/Swiss-Prot Function:
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
UniProtKB/Swiss-Prot Induction:
Not induced by endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CDNF: view
genes like me logo Genes that share phenotypes with CDNF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDNF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDNF Gene

Localization for CDNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDNF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDNF Gene COMPARTMENTS Subcellular localization image for CDNF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with CDNF: view

Pathways & Interactions for CDNF Gene

SuperPathways for CDNF Gene

No Data Available

Interacting Proteins for CDNF Gene

Selected Interacting proteins: Q49AH0-CDNF_HUMAN for CDNF Gene via IID

Gene Ontology (GO) - Biological Process for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IBA --
GO:0071542 dopaminergic neuron differentiation IBA --
genes like me logo Genes that share ontologies with CDNF: view

No data available for Pathways by source and SIGNOR curated interactions for CDNF Gene

Transcripts for CDNF Gene

Unigene Clusters for CDNF Gene

Cerebral dopamine neurotrophic factor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDNF Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for CDNF Gene

GeneLoc Exon Structure for
CDNF
ECgene alternative splicing isoforms for
CDNF

Expression for CDNF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDNF Gene

mRNA differential expression in normal tissues according to GTEx for CDNF Gene

This gene is overexpressed in Muscle - Skeletal (x8.2) and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CDNF Gene

This gene is overexpressed in Tonsil (38.9), Liver (22.1), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDNF Gene



Protein tissue co-expression partners for CDNF Gene

NURSA nuclear receptor signaling pathways regulating expression of CDNF Gene:

CDNF

SOURCE GeneReport for Unigene cluster for CDNF Gene:

Hs.559067

mRNA Expression by UniProt/SwissProt for CDNF Gene:

Q49AH0-CDNF_HUMAN
Tissue specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
genes like me logo Genes that share expression patterns with CDNF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDNF Gene

Orthologs for CDNF Gene

This gene was present in the common ancestor of animals.

Orthologs for CDNF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDNF 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CDNF 34 35
  • 87.52 (n)
dog
(Canis familiaris)
Mammalia CDNF 34 35
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Cdnf 34 16 35
  • 82.89 (n)
rat
(Rattus norvegicus)
Mammalia Cdnf 34
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia CDNF 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDNF 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDNF 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdnf 34
  • 67.13 (n)
zebrafish
(Danio rerio)
Actinopterygii cdnf 34 35
  • 59.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Manf 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.23 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9334 35
  • 47 (a)
OneToMany
Species where no ortholog for CDNF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDNF Gene

ENSEMBL:
Gene Tree for CDNF (if available)
TreeFam:
Gene Tree for CDNF (if available)

Paralogs for CDNF Gene

Paralogs for CDNF Gene

(1) SIMAP similar genes for CDNF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDNF: view

Variants for CDNF Gene

Sequence variations from dbSNP and Humsavar for CDNF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10906771 -- 14,839,577(+) AAAAA(A/C)AAAAA intron-variant, upstream-variant-2KB
rs111208036 -- 14,826,250(+) AAGCA(G/T)AAGAA intron-variant
rs111346775 -- 14,827,885(+) AGACT(-/CT)GTCTC intron-variant
rs111369384 -- 14,826,479(+) AAGAA(A/G)AAAAA intron-variant
rs111388859 -- 14,819,859(+) AATAC(C/T)AACAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDNF Gene

Variant ID Type Subtype PubMed ID
nsv1043133 CNV loss 25217958
nsv471664 CNV gain+loss 15918152
nsv5899 CNV insertion 18451855

Variation tolerance for CDNF Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDNF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDNF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDNF Gene

Disorders for CDNF Gene

Relevant External Links for CDNF

Human Genome Epidemiology (HuGE) Navigator
CDNF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDNF

No disorders were found for CDNF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDNF Gene

Publications for CDNF Gene

  1. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. (PMID: 17611540) Lindholm P. … Saarma M. (Nature 2007) 2 3 4 64
  2. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PMID: 19258449) Parkash V. … Goldman A. (Protein Eng. Des. Sel. 2009) 3 4 64
  3. Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. (PMID: 25975173) Kemppainen S. … Tanila H. (Behav. Brain Res. 2015) 3 64
  4. The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against I+-Synuclein Oligomers. (PMID: 26149686) Latge C. … Foguel D. (J. Biol. Chem. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CDNF Gene

  • Cloud-Clone Corp. Antibodies for CDNF
  • Cloud-Clone Corp. Proteins for CDNF
  • Cloud-Clone Corp Assay Kits for CDNF

Sources for CDNF Gene

Content
Loading form....