CDNF Gene
protein-coding GIFtS: 48
GCID: GC10M014771
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cerebral dopamine neurotrophic factor(Previous names: arginine-rich, mutated in early stage tumors-like 1 )
(Previous symbol: ARMETL1)
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Aliases
for CDNF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cerebral Dopamine Neurotrophic Factor1 2 | | ARMETL11 2 3 | | Arginine-Rich, Mutated In Early Stage Tumors-Like 11 2 | | Conserved Dopamine Neurotrophic Factor2 3 | | ARMET-Like Protein 12 3 |
Export aliases for CDNF gene to outside databasesPrevious GC identifers: GC10M014902 GC10M014861 |
Summaries
for CDNF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CDNF_HUMAN, Q49AH0Function: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration ofdopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents thedegeneration of dopaminergic neurons in substantia nigra (By similarity)
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Genomic Views
for CDNF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CDNF
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDNF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDNF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13CDNF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M014771: view genomic region
(about GC identifiers)
Start:
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14,861,249 bp from pter |
End:
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14,880,574 bp from pter |
Size:
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19,326 bases |
Orientation:
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minus strand |
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Proteins
for CDNF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDNF_HUMAN, Q49AH0 (See
protein sequence)Recommended Name: Cerebral dopamine neurotrophic factor precursor Size: 187 amino acids; 20964 Da
Subcellular location: Secreted
1 PDB 3D structure from  and Proteopedia  for CDNF:2W50 (3D)
Secondary accessions: A2RUU0 B4DVW3Alternative splicing: 2 isoforms: Q49AH0-1 Q49AH0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CDNF: NX_Q49AH0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q49AH0
CDNF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001025125.2
ENSEMBL proteins: ENSP00000367703 ENSP00000419395
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CDNF for ontologies About GeneDecksing
CDNF Antibody Products:
Assay Products for CDNF: |
Protein
Domains /
Families
for CDNF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDNF for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q49AH0ProtoNet protein and cluster: Q49AH0 UniProtKB/Swiss-Prot: CDNF_HUMAN, Q49AH0Similarity: Belongs to the ARMET family |
Function
for CDNF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDNF_HUMAN, Q49AH0Function: Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration ofdopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents thedegeneration of dopaminergic neurons in substantia nigra (By similarity)Induction: Not induced by endoplasmic reticulum stress
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDNF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDNF |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008083 | growth factor activity |
IEA | -- |
CDNF for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CDNF:
|
Pathways & Interactions
for CDNF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDNF
|
Drugs & Compounds
for CDNF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDNF
Search CenterWatch for drugs/clinical trials and news about CDNF
|
Transcripts
for CDNF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDNF gene: NM_001029954.2 Unigene Cluster for CDNF: Cerebral dopamine neurotrophic factor Hs.559067 [show with all ESTs]Unigene Representative Sequence: BC0378725 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378442(uc001inb.1 uc010qbv.1 uc001inc.1) ENST00000378441
ENST00000467405 ENST00000466269 ENST00000465530
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDNF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDNF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDNF (NM_001029954) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDNF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDNF |
Additional cDNA sequence: AK131035.1 BC037872.1 BC133042.1 BC133044.1 BC144619.1 5 DOTS entries: DT.435105 DT.95320632 DT.121272798 DT.95262524 DT.86848108 24/25 AceView cDNA sequences (see all 25): AA018896 F31353 CK903443 BI964826 AI810745 BG742772 BI963176 AI214900 BQ025443 AI807908 AA019552 BG213461 AA885943 BC037872 AW450272 AK131035 BI464979 BM984171 BG742840 T68138 AV657190 AA018863 BQ321568 AA019437
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CDNF About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b |
|---|
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| SP1: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDNF
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Expression
for CDNF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDNF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTTGTGT
About this image
See CDNF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDNF
SOURCE GeneReport for Unigene cluster: Hs.559067
UniProtKB/Swiss-Prot: CDNF_HUMAN, Q49AH0Tissue specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the opticnerve and corpus callosum
SABiosciences Custom PCR Arrays for CDNF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDNF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDNF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDNF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDNF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDNF |
Orthologs
for CDNF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDNF gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cdnf1 , 5 |
cerebral dopamine neurotrophic factor1, 5 |
82.89(n)1
77.54(a)1 |
|
2 (1.99 cM)5
2275261 NM_177647.41 NP_808315.11
35130305 |
zebrafish
(Danio rerio) |
Actinopterygii |
cdnf6 |
cerebral dopamine neurotrophic factor |
46(a) |
1 ↔ 1 |
4(8650204-8654638) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Manf6 |
Mesencephalic astrocyte-derived neurotrophic facto... |
46(a) |
1 → many |
3R(12175126-12176523) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y54G2A.236 |
MANF/CDNF-like protein |
43(a) |
1 → many |
IV(2927513-2928421) |
ENSEMBL Gene Tree for CDNF (if available)
TreeFam Gene Tree for CDNF (if available) |
Paralogs
for CDNF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDNF gene
- MANF2
1 SIMAP similar gene for CDNF using alignment to 1 protein entry: CDNF_HUMAN:MANF
CDNF for paralogs About GeneDecksing
|
Genomic Variants
for CDNF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDNF (14861249 - 14880574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDNF: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDNF |
|
Disorders
/ Diseases
for CDNF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDNF for disorders About GeneDecksing
OMIM gene information: 611233
OMIM disorders: --
8  diseases for CDNF: About MalaCardscerebritis corpus callosum cocaine dependence parkinson's disease
hepatocellular carcinoma carcinoma pancreatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for CDNF:Parkinson's disease Human Genome Epidemiology (HuGE) Navigator: CDNF (2 documents)
Export disorders for CDNF gene to outside databases
|
Publications
for CDNF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDNF gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CDNF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. (PubMed id 17611540)1, 2, 3 Lindholm P.... Saarma M. (2007)
- The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PubMed id 19258449)1, 2 Parkash V.... Goldman A. (2009)
- Analysis of mutations and the association between pol ymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkins on disease. (PubMed id 21320571)1 Choi J.M....Kim Y.J. (2011)
- Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. (PubMed id 19429035)1 Lohoff F.W....Oslin D.W. (2009)
- Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. (PubMed id 18561914)2 Apostolou A....Fang S. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. (PubMed id 11752456)1 Xu X.R.... Han Z.G. (2001)
|
External Searches for CDNF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDNF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDNF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDNF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDNF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDNF gene:
Search GeneIP for patents involving CDNF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDNF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for CDNF | | OriGene Custom Protein Services for CDNF | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDNF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDNF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDNF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDNF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDNF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDNF |
| |
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| |  |  |  |  | | | | | | Recombinant Protein for CDNF |
|
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 | | | CDNF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDNF |
|  |  |  | | | | ThermoFisher Antibodies for CDNF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDNF |
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