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Aliases for CDKN3 Gene

Aliases for CDKN3 Gene

  • Cyclin-Dependent Kinase Inhibitor 3 2 3
  • Cyclin-Dependent Kinase-Interacting Protein 2 3 4
  • CDK2-Associated Dual Specificity Phosphatase 2 3
  • CDK2-Associated Dual-Specificity Phosphatase 3 4
  • Cyclin-Dependent Kinase Interactor 1 3 4
  • Kinase Associated Phosphatase 2 3
  • Kinase-Associated Phosphatase 3 4
  • CDI1 3 4
  • CIP2 3 4
  • KAP 3 4
  • Cyclin-Dependent Kinase Interacting Protein 2 3
  • Cdk-Associated Protein Phosphatase 3
  • Cyclin-Dependent Kinase Inhibitor 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KAP1 3

External Ids for CDKN3 Gene

Previous GeneCards Identifiers for CDKN3 Gene

  • GC14P052187
  • GC14P048659
  • GC14P052853
  • GC14P053933
  • GC14P054863
  • GC14P035026

Summaries for CDKN3 Gene

Entrez Gene Summary for CDKN3 Gene

  • The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for CDKN3 Gene

CDKN3 (Cyclin-Dependent Kinase Inhibitor 3) is a Protein Coding gene. Diseases associated with CDKN3 include bubonic plague and hepatocellular carcinoma. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for CDKN3 Gene

  • May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at Thr-160 in a cyclin-dependent manner.

Gene Wiki entry for CDKN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN3 Gene

Genomics for CDKN3 Gene

Regulatory Elements for CDKN3 Gene

Genomic Location for CDKN3 Gene

Start:
54,396,849 bp from pter
End:
54,420,218 bp from pter
Size:
23,370 bases
Orientation:
Plus strand

Genomic View for CDKN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN3 Gene

Proteins for CDKN3 Gene

  • Protein details for CDKN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16667-CDKN3_HUMAN
    Recommended name:
    Cyclin-dependent kinase inhibitor 3
    Protein Accession:
    Q16667
    Secondary Accessions:
    • Q53ZU6
    • Q5U0M4
    • Q6P1N8
    • Q99585
    • Q9BPW7
    • Q9BY36
    • Q9C042
    • Q9C046
    • Q9C047
    • Q9C049
    • Q9C051
    • Q9C053

    Protein attributes for CDKN3 Gene

    Size:
    212 amino acids
    Molecular mass:
    23805 Da
    Quaternary structure:
    • Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.

    Three dimensional structures from OCA and Proteopedia for CDKN3 Gene

    Alternative splice isoforms for CDKN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDKN3 Gene

Proteomics data for CDKN3 Gene at MOPED

Post-translational modifications for CDKN3 Gene

  • Ubiquitination at Lys184
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDKN3 Gene

Domains for CDKN3 Gene

Gene Families for CDKN3 Gene

HGNC:
  • DUSPC :Protein tyrosine phosphatases / Class I Cys-based PTPs : CDC14s

Protein Domains for CDKN3 Gene

Suggested Antigen Peptide Sequences for CDKN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16667

UniProtKB/Swiss-Prot:

CDKN3_HUMAN :
  • Q16667
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with CDKN3: view

Function for CDKN3 Gene

Molecular function for CDKN3 Gene

GENATLAS Biochemistry: cyclin dependent kinases CDC2 (CDK1) and CDK2 (CDC2/CDK2) inhibitor,expressed at the G1 to S transition of the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at Thr-160 in a cyclin-dependent manner.
UniProtKB/Swiss-Prot Induction: Up-regulated in breast and prostate cancer cells.

Enzyme Numbers (IUBMB) for CDKN3 Gene

Gene Ontology (GO) - Molecular Function for CDKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004722 protein serine/threonine phosphatase activity IDA 12745075
GO:0004725 protein tyrosine phosphatase activity IDA 8242750
GO:0005515 protein binding IPI 11463386
GO:0008138 protein tyrosine/serine/threonine phosphatase activity TAS 8242750
genes like me logo Genes that share ontologies with CDKN3: view
genes like me logo Genes that share phenotypes with CDKN3: view

miRNA for CDKN3 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDKN3 Gene

Localization for CDKN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN3 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN3 Gene COMPARTMENTS Subcellular localization image for CDKN3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CDKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IDA 10669749
genes like me logo Genes that share ontologies with CDKN3: view

Pathways for CDKN3 Gene

SuperPathways for CDKN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8242750
GO:0000082 G1/S transition of mitotic cell cycle TAS 8127873
GO:0006470 protein dephosphorylation --
GO:0007050 cell cycle arrest IDA 8242750
GO:0008285 negative regulation of cell proliferation TAS 8242750
genes like me logo Genes that share ontologies with CDKN3: view

No data available for Pathways by source for CDKN3 Gene

Compounds for CDKN3 Gene

(3) HMDB Compounds for CDKN3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(123) Novoseek inferred chemical compound relationships for CDKN3 Gene

Compound -log(P) Hits PubMed IDs
okadaic acid 92.6 112
calyculin a 88.8 72
tyrosine 86.7 147
threonine 84.8 103
phosphotyrosine 82.7 61
genes like me logo Genes that share compounds with CDKN3: view

Transcripts for CDKN3 Gene

Unigene Clusters for CDKN3 Gene

Cyclin-dependent kinase inhibitor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6: -

Relevant External Links for CDKN3 Gene

GeneLoc Exon Structure for
CDKN3
ECgene alternative splicing isoforms for
CDKN3

Expression for CDKN3 Gene

mRNA expression in normal human tissues for CDKN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDKN3 Gene

This gene is overexpressed in Testis (23.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKN3 Gene

SOURCE GeneReport for Unigene cluster for CDKN3 Gene Hs.84113

genes like me logo Genes that share expressions with CDKN3: view

No data available for mRNA Expression by UniProt/SwissProt for CDKN3 Gene

Orthologs for CDKN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN3 35
  • 99.53 (n)
  • 98.58 (a)
CDKN3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN3 35
  • 91.67 (n)
  • 91.98 (a)
CDKN3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkn3 35
  • 88.47 (n)
  • 89.57 (a)
Cdkn3 16
Cdkn3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDKN3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDKN3 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDKN3 35
  • 69.42 (n)
  • 66.99 (a)
CDKN3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN3 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4052 35
zebrafish
(Danio rerio)
Actinopterygii cdkn3 35
  • 64.08 (n)
  • 59.71 (a)
cdkn3 36
  • 59 (a)
OneToOne
Dr.24317 35
Species with no ortholog for CDKN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN3 Gene

ENSEMBL:
Gene Tree for CDKN3 (if available)
TreeFam:
Gene Tree for CDKN3 (if available)

Paralogs for CDKN3 Gene

No data available for Paralogs for CDKN3 Gene

Variants for CDKN3 Gene

Sequence variations from dbSNP and Humsavar for CDKN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1007397 -- 54,420,336(+) GTAAT(A/G)CTGAA downstream-variant-500B
rs1803843 - 54,417,875(+) CCTGT(C/T)TGACA reference, missense
rs1884013 -- 54,398,079(+) TGAGC(G/T)GATAT intron-variant
rs1884014 -- 54,398,245(+) AGGTG(C/G)TTACA intron-variant
rs2103777 -- 54,407,305(+) TCCCC(G/T)TTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN3 Gene

Variant ID Type Subtype PubMed ID
nsv832801 CNV Gain 17160897

Relevant External Links for CDKN3 Gene

HapMap Linkage Disequilibrium report
CDKN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN3 Gene

Disorders for CDKN3 Gene

UniProtKB/Swiss-Prot

CDKN3_HUMAN
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269 PubMed:10987270}. Note=The gene represented in this entry may be involved in disease pathogenesis.

(96) Novoseek inferred disease relationships for CDKN3 Gene

Disease -log(P) Hits PubMed IDs
cowden disease 78.7 20
lafora disease 68.3 12
bannayan-zonana syndrome 67.2 3
centronuclear myopathy 64 5
paired helical filament 61.8 1

Relevant External Links for CDKN3

Genetic Association Database (GAD)
CDKN3
Human Genome Epidemiology (HuGE) Navigator
CDKN3
genes like me logo Genes that share disorders with CDKN3: view

Publications for CDKN3 Gene

  1. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PMID: 8242750) Gyuris J. … Brent R. (Cell 1993) 2 3 4 23
  2. Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. (PMID: 10669749) Lee S.W. … Aaronson S.A. (Mol. Cell. Biol. 2000) 3 4 23
  3. Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. (PMID: 15671017) Chinami M. … Adra C.N. (J. Biol. Chem. 2005) 3 4 23
  4. Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). (PMID: 7698009) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1995) 2 3 23
  5. Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. (PMID: 12745075) Yeh C.-T. … Chao M.-L. (Biochem. Biophys. Res. Commun. 2003) 3 4 23

Products for CDKN3 Gene

Sources for CDKN3 Gene

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