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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDKN3 Gene

protein-coding GIFtS: 56
GCID: GC14P054863

cyclin-dependent kinase inhibitor 3

Explore 198 diseases affiliated with
CDKN3 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase Inhibitor 3¹ ²		KAP1²
CDI1¹ ² ³		Cdk-Associated Protein Phosphatase²
KAP¹ ² ³		CDK2-Associated Dual Specificity Phosphatase²
Cyclin-Dependent Kinase Interactor 1² ³		Cyclin-Dependent Kinase Interacting Protein 2²
Cyclin-Dependent Kinase-Interacting Protein 2² ³		Kinase Associated Phosphatase²
Kinase-Associated Phosphatase² ³		EC 3.1.3.16³
CIP2² ³		EC 3.1.3.48³
CDK2-Associated Dual-Specificity Phosphatase² ³

External Ids:	HGNC: 1791¹	Entrez Gene: 1033²	Ensembl: ENSG00000100526⁷	OMIM: 123832⁵	UniProtKB: Q16667³

Export aliases for CDKN3 gene to outside databases

Previous GC identifers: GC14P052187 GC14P048659 GC14P052853 GC14P053933 GC14P035026

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN3:

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a

cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent

the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of

cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CDKN3_HUMAN, Q16667

Function: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing

either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner

Gene Wiki entry for CDKN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDKN3 gene promoter:
CUTL1 Nkx2-5 CBF-C CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDKN3 promoter sequence

Search SABiosciences Chromatin IP Primers for CDKN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22 Ensembl cytogenetic band: 14q22.2 HGNC cytogenetic band: 14q22

CDKN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P054863: view genomic region (about GC identifiers)

Start:	54,863,567 bp from pter	End:	54,886,936 bp from pter
Size:	23,370 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDKN3_HUMAN, Q16667 (See protein sequence)

Recommended Name: Cyclin-dependent kinase inhibitor 3

Size: 212 amino acids; 23805 Da

Subunit: Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts

(via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the

interaction enhances CDKN3 enzymatic activity

Subcellular location: Cytoplasm, perinuclear region

2 PDB 3D structures from and Proteopedia for CDKN3:

1FPZ (3D)

1FQ1 (3D)

Secondary accessions: Q53ZU6 Q5U0M4 Q6P1N8 Q99585 Q9BPW7 Q9BY36 Q9C042 Q9C046 Q9C047 Q9C049 Q9C051

Q9C053

Alternative splicing: 2 isoforms: Q16667-1 Q16667-2

Explore the universe of human proteins at neXtProt for CDKN3: NX_Q16667

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16667

CDKN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001124323.1 NP_005183.2

ENSEMBL proteins:

ENSP00000335357 ENSP00000440404 ENSP00000415333 ENSP00000396451 ENSP00000450711

ENSP00000445572 ENSP00000378944

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	ProSpec Recombinant Protein for CDKN3
	Uscn Proteins for CDKN3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0048471	perinuclear region of cytoplasm	IDA	10669749

CDKN3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CDKN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDKN3 for domains About GeneDecksing

3 InterPro domains/families:

IPR022778 CDKN3

IPR000387 Tyr/Dual-sp_Pase

IPR008425 CDK_inhib_3

Graphical View of Domain Structure for InterPro Entry Q16667

ProtoNet protein and cluster: Q16667

UniProtKB/Swiss-Prot: CDKN3_HUMAN, Q16667

Similarity: Belongs to the protein-tyrosine phosphatase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDKN3_HUMAN, Q16667

Function: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing

either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Induction: Up-regulated in breast and prostate cancer cells

Genatlas biochemistry entry for CDKN3:

cyclin dependent kinases CDC2 (CDK1) and CDK2 (CDC2/CDK2) inhibitor,expressed at the G1 to S transition of the cell

cycle

Enzyme Numbers (IUBMB): EC 3.1.3.16¹ EC 3.1.3.48¹

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate CDKN3:
		hsa-miR-3130-3p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004722	protein serine/threonine phosphatase activity	IDA	12745075
GO:0004725	protein tyrosine phosphatase activity	IDA	8242750
GO:0005515	protein binding	IPI	11463386
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	TAS	8242750

CDKN3 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for CDKN3:

Decreased focal adhesion (FA)	Decreased nuclei size in G2M	Increased cell death in breast	Increased gamma-H2AX phosphory
Paclitaxel antagonistic effect

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDKN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for CDKN3 (Q16667^{1, 2, 3} ENSP00000335357⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK2	P24941¹^,²^,³, ENSP00000266970⁴	EBI-1031527,EBI-375096 MINT-17387 MINT-17388 MINT-24981 I2D: score=6 STRING: ENSP00000266970
CDK3	Q00526²^,³, ENSP00000400088⁴	MINT-17536 I2D: score=3 STRING: ENSP00000400088
CDK1	P06493²^,³	MINT-14184 I2D: score=4
CDC25A	P30304³, ENSP00000303706⁴	I2D: score=2 STRING: ENSP00000303706
MS4A3	Q96HJ5³, ENSP00000278865⁴	I2D: score=2 STRING: ENSP00000278865

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	8242750
GO:0000082	G1/S transition of mitotic cell cycle	TAS	8127873
GO:0007050	cell cycle arrest	IDA	8242750
GO:0008285	negative regulation of cell proliferation	TAS	8242750
GO:0035335	peptidyl-tyrosine dephosphorylation	IDA	8242750

CDKN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDKN3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDKN3

3 HMDB Compounds for CDKN3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/123 Novoseek chemical compound relationships for CDKN3 gene (see all 123) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
okadaic acid	92.6	314	14692510 (4), 1324932 (2), 1328535 (2), 8883894 (2) (see all 99)
calyculin a	88.8	76	12207043 (2), 10358111 (2), 7617443 (1), 9003077 (1) (see all 70)
tyrosine	86.7	670	1723248 (3), 12616716 (3), 7542629 (3), 10318859 (3) (see all 99)
threonine	84.8	124	12562757 (3), 15704110 (2), 8209781 (2), 1325458 (1) (see all 99)
phosphotyrosine	82.7	65	8550553 (2), 1965146 (2), 11698252 (2), 15501071 (2) (see all 57)
p-nitrophenyl phosphate	80.3	40	1655274 (1), 12479873 (1), 18809681 (1), 20071031 (1) (see all 33)
serine	80	146	12562757 (3), 8209781 (2), 1373816 (1), 1325458 (1) (see all 99)
sodium orthovanadate	79.1	40	7510864 (1), 9298995 (1), 10633075 (1), 19833736 (1) (see all 36)
vanadate	78.2	66	18255153 (2), 9160662 (2), 1514600 (1), 8330859 (1) (see all 58)
phosphatidylinositol-3,4,5-trisphosphate	77.1	13	8537357 (1), 11250155 (1), 14561749 (1), 19689267 (1) (see all 13)

Search CenterWatch for drugs/clinical trials and news about CDKN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDKN3 gene (2 alternative transcripts):

NM_001130851.1 NM_005192.3

Unigene Cluster for CDKN3:

Cyclin-dependent kinase inhibitor 3

Hs.84113 [show with all ESTs]

Unigene Representative Sequence: BQ056337

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000555837 ENST00000335183(uc001xap.3 uc001xar.3 uc010aoj.2)

ENST00000543789(uc010aoi.1) ENST00000442975 ENST00000458126 ENST00000556102

ENST00000541304 ENST00000216414 ENST00000556305 ENST00000555777 ENST00000395577

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate CDKN3:
		hsa-miR-3130-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CDKN3 3' UTR sequence

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Additional cDNA sequence:

AF213033.1 AF213034.1 AF213035.1 AF213036.1 AF213037.1 AF213038.1 AF213039.1 AF213040.1

AF213041.1 AF213042.1 AF213044.1 AF213045.1 AF213046.1 AF213047.1 AF213048.1 AF213049.1

AF213050.1 AF213051.1 AF213052.1 AF213053.1 AK098653.1 AK293265.1 AY257474.1 AY257475.1

AY257476.1 AY257477.1 AY257478.1 AY257479.1 BC064965.1 BC103633.1 BT019451.1 CR407666.1

EF560750.1 L25876.1 L27711.1 U02681.1

6 DOTS entries:

DT.100689659 DT.120762491 DT.91702665 DT.455366 DT.95140632 DT.95363338

24/132 AceView cDNA sequences (see all 132):

AA284072 AK098653 AI372907 AA055005 CR609253 BM781889 BE794067 BU508532

AI075136 NM_005192 CA429066 CR621708 BM838292 CA423508 BP370235 BC064965

BM091308 BM842007 AI076701 AA257019 AA315766 BQ776294 AA158059 BU618918

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN3 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:
SP2:
SP3:																			-
SP4:											-
SP5:

ECgene alternative splicing isoforms for CDKN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDKN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGATATT

About this image

CDKN3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDKN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDKN3

SOURCE GeneReport for Unigene cluster: Hs.84113

SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN3:

Oncogenes & Tumor Suppressor Genes in human mouse rat

Cell Cycle in human mouse rat

Protein Phosphatases in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDKN3 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdkn3^{1 , 5}	cyclin-dependent kinase inhibitor 3^{1, 5}	88.47(n)¹ 89.57(a)¹		14 (24.28 cM)⁵ 72391¹ NM_028222.1¹ NP_082498.1¹ 46760541⁵
chicken (Gallus gallus)	Aves	CDKN3¹	cyclin-dependent kinase inhibitor 3 (CDK2-associated more	70.15(n) 68.66(a)		423562 NM_001252162.1 NP_001239091.1
lizard (Anolis carolinensis)	Reptilia	CDKN3⁶	--	66(a)	1 ↔ 1	GL343533.1(198289-204508)
zebrafish (Danio rerio)	Actinopterygii	Dr.24317²	Danio rerio, Similar to cyclin-dependent kinase inhibitor more	71.93(n)		BC049021.1

ENSEMBL Gene Tree for CDKN3 (if available)
TreeFam Gene Tree for CDKN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79949630^1,2		--	54861676(+)	`TTCTAC/TGTCTA`	2	--	us2k¹		1		WA	118
rs180761163^1,2		--	54861698(+)	`CCACCC/TACATT`	2	--	us2k¹		0	--	--	--	--
rs8007223^1,2	C,F,A,H,	--	54861808(+)	`CCCTAC/TTAAGG`	2	--	us2k¹		24		NS EA NA CSA WA	2556
rs184761431^1,2		--	54861827(+)	`TGAGGA/GAGCAG`	2	--	us2k¹		0	--	--	--	--
rs189164221^1,2		--	54861828(+)	`GAGGAA/GGCAGA`	2	--	us2k¹		0	--	--	--	--
rs149183544^1,2		--	54861845(+)	`TTAAA-/AGAGAGC`	2	--	us2k¹		0	--	--	--	--
rs73268884^1,2	C,	--	54861855(+)	`GCAGTA/GTTTCC`	2	--	us2k¹		2		WA	120
rs181560720^1,2		--	54861863(+)	`TCCCAA/CGTAGC`	2	--	us2k¹		0	--	--	--	--
rs144751403^1,2		--	54861906(+)	`TTTGGA/CCTTTG`	2	--	us2k¹		0	--	--	--	--
rs4251585^1,2	F	--	54862007(+)	`TGGAAA/GATCTC`	2	--	us2k¹		1		NS	168

HapMap Linkage Disequilibrium report for CDKN3 (54863567 - 54886936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDKN3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CDKN3 for disorders About GeneDecksing

OMIM gene information: 123832 OMIM disorders: --

UniProtKB/Swiss-Prot: CDKN3_HUMAN, Q16667

Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550]

20/198 diseases for CDKN3 (see all 198): About MalaCards

bannayan-riley-ruvalcaba syndrome peutz-jeghers syndrome bubonic plague estrogen-receptor negative breast cancer

adult-onset still's disease b-cell non-hodgkin lymphoma progressive myoclonus epilepsy cerebral cavernous malformations

cavernous malformation diffuse large b-cell lymphoma human t-cell leukemia virus type 1 non-hodgkin lymphoma

myoclonus epilepsy complex regional pain syndrome juvenile myelomonocytic leukemia tropical spastic paraparesis

centronuclear myopathy non-small cell lung carcinoma spastic paraparesis b-cell lymphomas

10/96 Novoseek disease relationships for CDKN3 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cowden disease	78.7	21	11297621 (1), 15120218 (1), 17489063 (1), 18794875 (1) (see all 20)
lafora disease	68.3	14	14532330 (3), 12915448 (1), 15651314 (1), 15930137 (1) (see all 10)
bannayan-zonana syndrome	67.2	3	11964046 (1), 9256433 (1), 10959096 (1)
centronuclear myopathy	64	6	10900271 (1), 12884002 (1), 17008356 (1), 11001925 (1) (see all 5)
paired helical filament	61.8	1	8529836 (1)
tumors	57.8	405	10903528 (3), 15205473 (2), 1965146 (2), 16142898 (2) (see all 99)
cancer	56.3	166	12616716 (3), 19636948 (2), 9787181 (1), 15205473 (1) (see all 99)
progressive myoclonus epilepsies	54.7	5	15930137 (1), 11001928 (1), 11355878 (1), 11739371 (1) (see all 5)
glioblastoma	54.4	27	17483362 (2), 17219740 (1), 18088600 (1), 18804099 (1) (see all 24)
cmt4b	53.7	1	12646134 (1)

Human Genome Epidemiology (HuGE) Navigator: CDKN3 (1 document)

Export disorders for CDKN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDKN3 gene, integrated from 9 sources (see all 2412):
(articles sorted by number of sources associating them with CDKN3)

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Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)^{1, 2, 3, 9} Gyuris J.... Brent R. (1993)
Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. (PubMed id 10669749)^{1, 2, 9} Lee S.W....Aaronson S.A. (2000)
Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. (PubMed id 15671017)^{1, 2, 9} Chinami M.... Adra C.N. (2005)
Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. (PubMed id 12745075)^{1, 2, 9} Yeh C.-T.... Chao M.-L. (2003)
Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). (PubMed id 7698009)^{1, 3, 9} Demetrick D.J....Beach D.H. (1995)
Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. (PubMed id 10987270)^{1, 2, 9} Yeh C.-T.... Liaw Y.-F. (2000)
Human HTm4 is a hematopoietic cell cycle regulator. (PubMed id 11781350)^{1, 2} Donato J.-L.... Adra C.N. (2002)
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. (PubMed id 11463386)^{1, 2} Song H....Barford D. (2001)
Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase- interacting phosphatase KAP in the absence of cyclin. (PubMed id 7569954)^{1, 2} Poon R.Y.C. and Hunter T. (1995)
KAP: a dual specificity phosphatase that interacts with cyclin- dependent kinases. (PubMed id 8127873)^{1, 2} Hannon G.J.... Beach D. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1033	HGNC: 1791	AceView: CDKN3	Ensembl:ENSG00000100526	euGenes: HUgn1033
ECgene: CDKN3	H-InvDB: CDKN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDKN3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDKN3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn3/

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cyclin-dependent kinase inhibitor 3

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CDKN3 Gene

cyclin-dependent kinase inhibitor 3

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