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CDKN2D Gene

protein-coding   GIFtS: 64
GCID: GC19M010677

Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4)

  See CDKN2D-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4)1 2     Cyclin-Dependent Kinase 4 Inhibitor D P192
INK4D2     Inhibitor Of Cyclin-Dependent Kinase 4d2
CDK Inhibitor P19INK4d2     p192
Cell Cycle Inhibitor, Nur77 Associating Protein2     p19-INK4D2
Cyclin-Dependent Kinase 4 Inhibitor D2     p19-INK4d3

External Ids:    HGNC: 17901   Entrez Gene: 10322   Ensembl: ENSG000001293557   OMIM: 6009275   UniProtKB: P552733   

Export aliases for CDKN2D gene to outside databases

Previous GC identifers: GC19M010808 GC19M010899 GC19M010522 GC19M010538 GC19M010255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKN2D Gene:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This
protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases,
thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript
of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a
maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown
to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced
variants of this gene, which encode an identical protein, have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDKN2D Gene:
CDKN2D (cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)) is a protein-coding gene. Diseases associated with CDKN2D include melanoma, malignant, somatic, and osteosarcoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot: CDN2D_HUMAN, P55273
Function: Interacts strongly with CDK4 and CDK6 and inhibits them

Gene Wiki entry for CDKN2D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN2D gene promoter:
         CBF-A   CBF-B   p53   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN2D promoter sequence
   Search Chromatin IP Primers for CDKN2D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

CDKN2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2D gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010677:  view genomic region     (about GC identifiers)

Start:
10,677,138 bp from pter      End:
10,679,735 bp from pter
Size:
2,598 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDN2D_HUMAN, P55273 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4 inhibitor D  
Size: 166 amino acids; 17700 Da
Subunit: Interacts with CDK6
2 PDB 3D structures from and Proteopedia for CDKN2D:
1BD8 (3D)        1BI8 (3D)    
Secondary accessions: Q13102 Q6FGE9

Explore the universe of human proteins at neXtProt for CDKN2D: NX_P55273

Explore proteomics data for CDKN2D at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDKN2D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001791.1  NP_524145.1  

    ENSEMBL proteins: 
     ENSP00000377224   ENSP00000337056  
    Reactome Protein details: P55273

    CDKN2D Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P55273

    ProtoNet protein and cluster: P55273

    UniProtKB/Swiss-Prot: CDN2D_HUMAN, P55273
    Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with CDKN2D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN2D_HUMAN, P55273
    Function: Interacts strongly with CDK4 and CDK6 and inhibits them

         Genatlas biochemistry entry for CDKN2D:
    cyclin dependent kinase 4 and 6 (CDK4/CDK6) inhibitor,p19,regulator of the cell cycle,passage through the G1
    checkpoint,expressed primarily in hematopoietic tissues

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IDA8741839
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI8741839
         
    Find genes that share ontologies with CDKN2D           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDKN2D:
     Increased Salmonella enterica   Increased cell number in G1, a 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdkn2d):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  muscle  nervous system  reproductive system 
     respiratory system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with CDKN2D           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKN2D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDKN2D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN2D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN2D

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDKN2D:
    hsa-mir-26b-5p (MIRT028887), hsa-mir-192-5p (MIRT026171), hsa-mir-331-3p (MIRT043416), hsa-mir-215-5p (MIRT024530)

    Block miRNA regulation of human, mouse, rat CDKN2D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKN2D (see all 11):
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-362-3p hsa-miR-539 hsa-miR-451 hsa-miR-570 hsa-miR-329 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDKN2D
    Predesigned siRNA for gene silencing in human, mouse, rat CDKN2D

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2D (NM_079421)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDN2D_HUMAN, P55273: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15750620
    GO:0005737cytoplasm IDA15750620
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDKN2D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKN2D About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5GPCR Pathway
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with CDKN2D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDKN2D
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Pancreatic Adenocarcinoma

    1 GeneGo (Thomson Reuters) Pathway for CDKN2D
        Immune response IL-10 signaling pathway

    1 BioSystems Pathway for CDKN2D
        G1 to S cell cycle control


    4 Reactome Pathways for CDKN2D
        Oxidative Stress Induced Senescence
    Senescence-Associated Secretory Phenotype (SASP)
    Oncogene Induced Senescence
    Cyclin D associated events in G1


    2 Kegg Pathways  (Kegg details for CDKN2D):
        FoxO signaling pathway
    Cell cycle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2D: 
              Cellular Senescence in human mouse rat
              Cancer Drug Resistance in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDKN2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CDKN2D (P552731, 2, 3 ENSP000003370564) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK6Q005341, 3, ENSP000002657344EBI-745859,EBI-295663 I2D: score=5 STRING: ENSP00000265734
    TBC1D17Q9HA652, 3, ENSP000002215434MINT-67668 I2D: score=4 STRING: ENSP00000221543
    CDK4P118023, ENSP000002579044I2D: score=5 STRING: ENSP00000257904
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    ACTG1P632613I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA8741839
    GO:0000082G1/S transition of mitotic cell cycle IDA10208428
    GO:0000278mitotic cell cycle TAS--
    GO:0000731DNA synthesis involved in DNA repair IMP15750620
    GO:0007050cell cycle arrest IDA10208428

    Find genes that share ontologies with CDKN2D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKN2D (CDN2D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDKN2D gene (2 alternative transcripts): 
    NM_001800.3  NM_079421.2  

    Unigene Cluster for CDKN2D:

    Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
    Hs.435051  [show with all ESTs]
    Unigene Representative Sequence: NM_001800
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393599(uc002mpa.3) ENST00000335766(uc002mpb.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDKN2D (see all 11):
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-362-3p hsa-miR-539 hsa-miR-451 hsa-miR-570 hsa-miR-329 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2D 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CDKN2D

    Additional mRNA sequence: 

    BC001822.2 CR542158.1 U20498.1 U40343.1 U49399.1 

    2 DOTS entries:

    DT.95103286  DT.100749508 

    Selected AceView cDNA sequences (see all 126):

    BF902750 CK824084 BI031174 BF901942 BE504281 BF902747 CA424868 NM_079421 
    AI824257 AA488276 CR614055 BM272734 BU689358 BM142409 BF901939 NM_001800 
    BI028054 BU542469 BC001822 AI421483 AW016510 AI540069 BE675345 BU077480 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKN2D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAAAAAAA
    CDKN2D Expression
    About this image


    CDKN2D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
    CDKN2D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKN2D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435051
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2D: 
              Cellular Senescence in human mouse rat
              Cancer Drug Resistance in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDKN2D
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN2D gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn2d1 , 5 cyclin-dependent kinase inhibitor 2D (p19, inhibits more1, 5 81.73(n)1
    86.75(a)1
      9 (7.76 cM)5
    125811  NM_009878.31  NP_034008.21 
     212884635 
    lizard
    (Anolis carolinensis)
    Reptilia CDKN2D6
    cyclin-dependent kinase inhibitor 2D (p19, inhibit...
    67(a)
    1 ↔ 1
    2(80414391-80420306)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdkn2d1 cyclin-dependent kinase inhibitor 2D (p19, inhibits more 65.07(n)
    68.49(a)
      780300  NM_001079371.1  NP_001072839.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003332521 cyclin-dependent kinase 4 inhibitor D-like 64.01(n)
    60.87(a)
      100333252  XM_002662236.3  XP_002662282.2 


    ENSEMBL Gene Tree for CDKN2D (if available)
    TreeFam Gene Tree for CDKN2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CDKN2D gene
    CDKN2A2  CDKN2C2  CDKN2B2  
    Selected SIMAP similar genes for CDKN2D using alignment to 1 protein entry:     CDN2D_HUMAN(see all similar genes):
    CDKN2C    CDKN2B    ANK3    ANK1    CDKN2A    ANK2
    ANKRD1    ANKRD44    LOC91526    ANKDD1B    ANKRD52    ANKDD1A
    ANKK1    ANKRD28    CASKIN1    HACE1    TNKS    ANKRD2

    Find genes that share paralogs with CDKN2D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKN2D (see all 94)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32182221,2
    C,F,H--10613677(-) ACAGAG/ACCGCC 1 -- ds500122Minor allele frequency- A:0.38NS EA NA WA CSA 2489
    rs1910463501,2
    --10613808(+) TCCCTG/TTCGCC 1 -- ds50010--------
    rs32182211,2
    C,F,H--10613937(-) GAAACC/TGCGAG 1 -- ds50015Minor allele frequency- T:0.02NS NA 520
    rs1154219991,2
    C,F--10613953(+) TCCCTT/ACCGTT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1832743331,2
    --10614045(+) ATCCAA/CGATCC 1 -- ds50010--------
    rs32182191,2
    C,F,H--10614236(-) TTGTAC/TAGCGT 1 -- ut31 ese34Minor allele frequency- T:0.01NS NA 356
    rs1422123971,2
    --10614283(+) ACTCAC/TAACTC 1 -- ut310--------
    rs32182181,2
    C,F,H--10614397(-) AGGGAG/ACCTAG 1 -- ut315Minor allele frequency- A:0.01NS NA 580
    rs1828372311,2
    C--10614462(+) CAGCAG/TCCTGA 1 -- ut310--------
    rs1884049571,2
    --10614536(+) CACCAA/CAAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDKN2D (10677138 - 10679735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDKN2D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911045CNV Loss21882294
    nsv833744CNV Loss17160897
    nsv911047CNV Loss21882294
    nsv911046CNV Loss21882294
    nsv911042CNV Loss21882294
    nsv833745CNV Loss17160897
    dgv3727n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600927    OMIM disorders: --

    2 diseases for CDKN2D:    
    About MalaCards
    melanoma, malignant, somatic    osteosarcoma


    Find genes that share disorders with CDKN2D           About GenesLikeMe

    5 Novoseek inferred disease relationships for CDKN2D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 50.2 3 10962575 (1), 15172750 (1), 15738662 (1)
    leukemia t-cell 38.7 1 15107822 (1)
    cancer 26.3 5 10962575 (1), 19401813 (1), 18507837 (1)
    osteosarcoma 22.1 2 9244358 (2)
    tumors 16.7 5 9111168 (1), 11301189 (1), 15738662 (1), 9244358 (1)

    Genetic Association Database (GAD): CDKN2D
    Human Genome Epidemiology (HuGE) Navigator: CDKN2D (11 documents)
    Tumor Gene Database (TGDB): CDKN2D

    Export disorders for CDKN2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKN2D gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with CDKN2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. (PubMed id 8575754)1, 2, 3, 9 Okuda T.... Downing J.R. (Genomics 1995)
    2. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. (PubMed id 8741839)1, 2, 9 Guan K.L.... Xiong Y. (Mol. Biol. Cell 1996)
    3. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    4. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (Carcinogenesis 2008)
    5. Mutation testing in melanoma families: INK4A, CDK4 and INK4D. (PubMed id 10390011)1, 2, 9 Newton Bishop J.A....Bishop D.T. (Br. J. Cancer 1999)
    6. Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). (PubMed id 9782052)1, 2, 9 Baumgartner R....Holak T.A. (Structure 1998)
    7. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    8. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4 Goode E.L....Sellers T.A. (amp 2009)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    10. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. (PubMed id 19141585)1, 4 Agarwal S.K....Marx S.J. (J. Clin. Endocrinol. Metab. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1032 HGNC: 1790 AceView: CDKN2D Ensembl:ENSG00000129355 euGenes: HUgn1032
    ECgene: CDKN2D Kegg: 1032 H-InvDB: CDKN2D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDKN2D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN2D Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn2d/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDKN2D gene:
    Search GeneIP for patents involving CDKN2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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