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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDKN2D Gene

protein-coding GIFtS: 61
GCID: GC19M010677

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Explore 28 diseases affiliated with
CDKN2D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4)¹ ²		Cyclin-Dependent Kinase 4 Inhibitor D²
INK4D¹ ²		Cyclin-Dependent Kinase 4 Inhibitor D P19²
P19¹		Inhibitor Of Cyclin-Dependent Kinase 4d²
CDK Inhibitor P19INK4d²		P19-INK4D¹
Cell Cycle Inhibitor, Nur77 Associating Protein²		P19-INK4d¹

External Ids:	HGNC: 1790¹	Entrez Gene: 1032²	Ensembl: ENSG00000129355⁷	OMIM: 600927⁵	UniProtKB: P55273³

Export aliases for CDKN2D gene to outside databases

Previous GC identifers: GC19M010808 GC19M010899 GC19M010522 GC19M010538 GC19M010255

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN2D:

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has

been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as

a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was

found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression

during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in

repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which

encode an identical protein, have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDN2D_HUMAN, P55273

Function: Interacts strongly with CDK4 and CDK6 and inhibits them

Gene Wiki entry for CDKN2D

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDKN2D gene promoter:
CBF-A CBF-B p53 NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDKN2D promoter sequence

Search SABiosciences Chromatin IP Primers for CDKN2D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13

CDKN2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2D gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M010677: view genomic region (about GC identifiers)

Start:	10,677,138 bp from pter	End:	10,679,735 bp from pter
Size:	2,598 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDN2D_HUMAN, P55273 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 4 inhibitor D

Size: 166 amino acids; 17700 Da

Subunit: Interacts with CDK6

Subcellular location: Nucleus. Cytoplasm

2 PDB 3D structures from and Proteopedia for CDKN2D:

1BD8 (3D)

1BI8 (3D)

Secondary accessions: Q13102 Q6FGE9

Explore the universe of human proteins at neXtProt for CDKN2D: NX_P55273

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55273

CDKN2D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001791.1 NP_524145.1

ENSEMBL proteins:

ENSP00000377224 ENSP00000337056

Reactome Protein details: P55273
Human Recombinant Protein Products for CDKN2D:

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	Uscn Proteins for CDKN2D

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	15750620
GO:0005737	cytoplasm	IDA	15750620
GO:0005829	cytosol	TAS	--

CDKN2D for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CDKN2D

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDKN2D for domains About GeneDecksing

2 InterPro domains/families:

IPR002110 Ankyrin_rpt

IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry P55273

ProtoNet protein and cluster: P55273

UniProtKB/Swiss-Prot: CDN2D_HUMAN, P55273

Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family

Similarity: Contains 4 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDN2D_HUMAN, P55273

Function: Interacts strongly with CDK4 and CDK6 and inhibits them

Genatlas biochemistry entry for CDKN2D:

cyclin dependent kinase 4 and 6 (CDK4/CDK6) inhibitor,p19,regulator of the cell cycle,passage through the G1

checkpoint,expressed primarily in hematopoietic tissues

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IDA	8741839
GO:0019901	protein kinase binding	IPI	8741839

CDKN2D for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CDKN2D:

Increased Salmonella enterica

Increased cell number in G1, a

13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdkn2d):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
homeostasis/metabolism	mortality/aging	muscle	nervous system	reproductive system
respiratory system	tumorigenesis	vision/eye

CDKN2D for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDKN2D

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		hsa-miR-548am hsa-miR-548d-3p hsa-miR-362-3p hsa-miR-539 hsa-miR-451 hsa-miR-570 hsa-miR-329 hsa-miR-548x

		SwitchGear 3'UTR luciferase reporter plasmid: CDKN2D 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2D

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	1.00			Cyclin D associated events in G1	0.32
	G1-S Phase Transition	0.67			G1 Phase	0.32

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Cell cycle

Cell cycle

0.57

G1 to S cell cycle control

0.38

Development_PDGF signaling via STATs and NF-kB

Immune response_IL-10 signaling pathway

0.28

Immune response IL-10 signaling pathway

0.28

IL-10 Pathway

IL-10 Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CDKN2D

Immune response IL-10 signaling pathway

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN2D

	G1-S Phase Transition
	Cyclins and Cell Cycle Regulation
	IL-10 Pathway
	Molecular Mechanisms of Cancer
	Pancreatic Adenocarcinoma

1 GeneGo (Thomson Reuters) Pathway for CDKN2D

Immune response IL-10 signaling pathway

1 BioSystems Pathway for CDKN2D

G1 to S cell cycle control

5 Reactome Pathways for CDKN2D

	G1 Phase
	Mitotic G1-G1/S phases
	Cell Cycle
	Cell Cycle, Mitotic
	Cyclin D associated events in G1

1 Kegg Pathway (Kegg details for CDKN2D):

Cell cycle

CDKN2D for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDKN2D

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/18 Interacting proteins for CDKN2D (P55273^{2, 3} ENSP00000337056⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBC1D17	Q9HA65²^,³, ENSP00000221543⁴	MINT-67668 I2D: score=4 STRING: ENSP00000221543
CDK4	P11802³, ENSP00000257904⁴	I2D: score=5 STRING: ENSP00000257904
BRCA1	P38398³, ENSP00000350283⁴	I2D: score=1 STRING: ENSP00000350283
CDK6	Q00534³, ENSP00000265734⁴	I2D: score=5 STRING: ENSP00000265734
ACTG1	P63261³	I2D: score=1

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IDA	8741839
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	IDA	10208428
GO:0000278	mitotic cell cycle	TAS	--
GO:0000731	DNA synthesis involved in DNA repair	IMP	15750620

CDKN2D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDKN2D
Search CenterWatch for drugs/clinical trials and news about CDKN2D / CDN2D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDKN2D gene (2 alternative transcripts):

NM_001800.3 NM_079421.2

Unigene Cluster for CDKN2D:

Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Hs.435051 [show with all ESTs]

Unigene Representative Sequence: NM_001800

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393599(uc002mpa.3) ENST00000335766(uc002mpb.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CDKN2D Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-548am hsa-miR-548d-3p hsa-miR-362-3p hsa-miR-539 hsa-miR-451 hsa-miR-570 hsa-miR-329 hsa-miR-548x

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Additional cDNA sequence:

BC001822.2 CR542158.1 U20498.1 U40343.1 U49399.1

2 DOTS entries:

DT.95103286 DT.100749508

24/126 AceView cDNA sequences (see all 126):

AA488276 CK824084 AI824257 CA424868 BF901939 NM_079421 BU689358 CR614055

BU542469 BM272734 BF902747 NM_001800 BI028054 BM142409 BI031174 BE504281

BC001822 BF902750 BF901942 BF901940 BI028447 AI057178 AI268736 BE503625

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDKN2D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAAAAAAA

About this image

CDKN2D expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDKN2D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDKN2D

SOURCE GeneReport for Unigene cluster: Hs.435051

SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN2D:

Cellular Senescence in human mouse rat

Cancer Drug Resistance in human mouse rat

MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2D gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdkn2d^{1 , 5}	cyclin-dependent kinase inhibitor 2D (p19, inhibits more^{1, 5}	81.73(n)¹ 86.75(a)¹		9 (7.76 cM)⁵ 12581¹ NM_009878.3¹ NP_034008.2¹ 21288463⁵
lizard (Anolis carolinensis)	Reptilia	CDKN2D⁶	--	67(a)	1 ↔ 1	2(80414391-80420306)
zebrafish (Danio rerio)	Actinopterygii	LOC100333252¹	cyclin-dependent kinase 4 inhibitor D-like	62.39(n) 58.78(a)		100333252 XM_002662236.2 XP_002662282.1

ENSEMBL Gene Tree for CDKN2D (if available)
TreeFam Gene Tree for CDKN2D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDKN2D gene

CDKN2A² CDKN2C² CDKN2B²

18/25 SIMAP similar genes for CDKN2D using alignment to 1 protein entry: CDN2D_HUMAN(see all similar genes):

CDKN2C CDKN2B ANK1 ANK3 CDKN2A ANK2

ANKRD1 ANKRD44 LOC91526 ANKRD52 ANKDD1A ANKK1

ANKRD28 CASKIN1 HACE1 TNKS ANKRD2 ANKRD50

CDKN2D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3218221^1,2	C,F,H	--	10254860(-)	`GAAACC/TGCGAG`	2	--	ds500¹		5		NS NA	520
rs3218219^1,2	C,F,H	--	10255159(-)	`TTGTAC/TAGCGT`	2	--	ut3¹ ese³		4		NS NA	356
rs3218218^1,2	C,F,H	--	10255320(-)	`AGGGAG/ACCTAG`	2	--	ut3¹		5		NS NA	580
rs3218217^1,2	C	--	10256253(-)	`GGGGGG/TCTGTT`	2	--	int¹		1		NS	180
rs3218216^1,2	C,F	--	10256363(-)	`TCTGGG/AGGCCC`	2	--	int¹		2		NS WA	298
rs3218214^1,2	C	--	10256569(-)	`TCCCTG/AGGAGA`	2	--	int¹		2		NS WA	296
rs191046350^1,2		--	10676812(+)	`TCCCTG/TTCGCC`	1	--	us2k¹		0	--	--	--	--
rs115421999^1,2	F	--	10676957(+)	`TCCCTT/ACCGTT`	1	--	us2k¹		1		WA	118
rs183274333^1,2		--	10677049(+)	`ATCCAA/CGATCC`	1	--	us2k¹		0	--	--	--	--
rs142212397^1,2		--	10677287(+)	`ACTCAC/TAACTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDKN2D (10677138 - 10679735 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDKN2D: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN2D

DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2D

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDKN2D for disorders           About GeneDecksing

OMIM gene information: 600927    OMIM disorders: --

20/28 diseases for CDKN2D (see all 28):    About MalaCards

testicular germ cell tumor multiple endocrine neoplasia germ cell tumor acute lymphoblastic leukemia

sporadic breast cancer lymphoblastic leukemia acute myeloid leukemia epithelial ovarian cancer

pituitary adenoma myeloid leukemia neuronitis malignant glioma

ovarian cancer myelodysplastic syndrome leukemia osteosarcoma

breast cancer adenoma nasopharyngitis prostate carcinoma

5 Novoseek disease relationships for CDKN2D gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	50.2	3	10962575 (1), 15172750 (1), 15738662 (1)
leukemia t-cell	38.7	1	15107822 (1)
cancer	26.3	5	10962575 (1), 19401813 (1), 18507837 (1)
osteosarcoma	22.1	2	9244358 (2)
tumors	16.7	5	9111168 (1), 11301189 (1), 15738662 (1), 9244358 (1)

Human Genome Epidemiology (HuGE) Navigator: CDKN2D (11 documents)
Tumor Gene Database (TGDB): CDKN2D

Export disorders for CDKN2D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDKN2D gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with CDKN2D)

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Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. (PubMed id 8575754)^{1, 2, 3, 9} Okuda T.... Downing J.R. (1995)
Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. (PubMed id 8741839)^{1, 2, 9} Guan K.L.... Xiong Y. (1996)
Mutation testing in melanoma families: INK4A, CDK4 and INK4D. (PubMed id 10390011)^{1, 2, 9} Newton Bishop J.A....Bishop D.T. (1999)
Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). (PubMed id 9782052)^{1, 2, 9} Baumgartner R....Holak T.A. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. (PubMed id 9751050)^{1, 2} Russo A.A.... Pavletich N.P. (1998)
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. (PubMed id 7739548)^{1, 2} Chan F.K.M.... Winoto A. (1995)
Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. (PubMed id 10962575)^{1, 9} Bartkova J....Bartek J. (2000)
Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. (PubMed id 15107822)^{1, 9} Yokota T....Sakai T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1032	HGNC: 1790	AceView: CDKN2D	Ensembl:ENSG00000129355	euGenes: HUgn1032
ECgene: CDKN2D	Kegg: 1032	H-InvDB: CDKN2D

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDKN2D	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDKN2D	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn2d/

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CDKN2D Gene

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

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cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

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