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Aliases for CDKN2D Gene

Aliases for CDKN2D Gene

  • Cyclin Dependent Kinase Inhibitor 2D 2 3 5
  • Cyclin-Dependent Kinase Inhibitor 2D (P19, Inhibits CDK4) 2 3
  • P19-INK4D 3 4
  • Cell Cycle Inhibitor, Nur77 Associating Protein 3
  • Cyclin-Dependent Kinase 4 Inhibitor D P19 3
  • Inhibitor Of Cyclin-Dependent Kinase 4d 3
  • Cyclin-Dependent Kinase 4 Inhibitor D 3
  • CDK Inhibitor P19INK4d 3
  • INK4D 3
  • P19 3

External Ids for CDKN2D Gene

Previous GeneCards Identifiers for CDKN2D Gene

  • GC19M010808
  • GC19M010899
  • GC19M010522
  • GC19M010538
  • GC19M010677
  • GC19M010255

Summaries for CDKN2D Gene

Entrez Gene Summary for CDKN2D Gene

  • The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKN2D Gene

CDKN2D (Cyclin Dependent Kinase Inhibitor 2D) is a Protein Coding gene. Diseases associated with CDKN2D include Malignant Melanoma, Somatic and Deafness, Autosomal Recessive 68. Among its related pathways are Cellular Senescence and Cyclins and Cell Cycle Regulation. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2C.

UniProtKB/Swiss-Prot for CDKN2D Gene

  • Interacts strongly with CDK4 and CDK6 and inhibits them.

Gene Wiki entry for CDKN2D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2D Gene

Genomics for CDKN2D Gene

Regulatory Elements for CDKN2D Gene

Enhancers for CDKN2D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010601 1.7 FANTOM5 ENCODE dbSUPER 33.7 -35.1 -35065 4.4 ARID4B DMAP1 ZNF2 ZNF766 ZNF143 SP3 SP5 REST TBX21 ZNF610 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 QTRT1 ZNF627 PRKCSH RPL10P15 ILF3-AS1
GH19G010595 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.1 -27.1 -27142 2.0 USF1 ZSCAN4 MAX EBF1 EGR1 ADNP RELB ETV6 IKZF2 MTA2 KRI1 CDKN2D SLC44A2 ICAM3 ATG4D ILF3 TYK2 DNM2 C19orf38 S1PR5
GH19G010564 1.7 FANTOM5 ENCODE dbSUPER 24.6 +1.7 1667 5.8 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 KRI1 CDKN2D SLC44A2 TYK2
GH19G010593 1.2 Ensembl ENCODE dbSUPER 27.6 -25.1 -25058 1.6 HDGF KLF1 USF1 EBF1 EED RELB IKZF2 MTA2 BHLHE40 NR2F1 CDKN2D KRI1 ILF3 ATG4D LOC100820734 AP1M2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDKN2D on UCSC Golden Path with GeneCards custom track

Promoters for CDKN2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CDKN2D Gene

10,566,462 bp from pter
10,569,059 bp from pter
2,598 bases
Minus strand

Genomic View for CDKN2D Gene

Genes around CDKN2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2D Gene

Proteins for CDKN2D Gene

  • Protein details for CDKN2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor D
    Protein Accession:
    Secondary Accessions:
    • Q13102
    • Q6FGE9

    Protein attributes for CDKN2D Gene

    166 amino acids
    Molecular mass:
    17700 Da
    Quaternary structure:
    • Interacts with CDK6.

    Three dimensional structures from OCA and Proteopedia for CDKN2D Gene

neXtProt entry for CDKN2D Gene

Post-translational modifications for CDKN2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for CDKN2D

No data available for DME Specific Peptides for CDKN2D Gene

Domains & Families for CDKN2D Gene

Gene Families for CDKN2D Gene

Protein Domains for CDKN2D Gene

Suggested Antigen Peptide Sequences for CDKN2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
genes like me logo Genes that share domains with CDKN2D: view

Function for CDKN2D Gene

Molecular function for CDKN2D Gene

GENATLAS Biochemistry:
cyclin dependent kinase 4 and 6 (CDK4/CDK6) inhibitor,p19,regulator of the cell cycle,passage through the G1 checkpoint,expressed primarily in hematopoietic tissues
UniProtKB/Swiss-Prot Function:
Interacts strongly with CDK4 and CDK6 and inhibits them.

Gene Ontology (GO) - Molecular Function for CDKN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 8741839
GO:0005515 protein binding IPI 9751050
GO:0016301 kinase activity IEA --
GO:0019901 protein kinase binding IPI 8741839
genes like me logo Genes that share ontologies with CDKN2D: view
genes like me logo Genes that share phenotypes with CDKN2D: view

Human Phenotype Ontology for CDKN2D Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDKN2D Gene

MGI Knock Outs for CDKN2D:

Animal Model Products

CRISPR Products

miRNA for CDKN2D Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDKN2D Gene

Localization for CDKN2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2D Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKN2D gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CDKN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8741839
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15750620
GO:0005829 cytosol TAS --
GO:0097129 cyclin D2-CDK4 complex IEA --
genes like me logo Genes that share ontologies with CDKN2D: view

Pathways & Interactions for CDKN2D Gene

genes like me logo Genes that share pathways with CDKN2D: view

Pathways by source for CDKN2D Gene

1 GeneTex pathway for CDKN2D Gene
1 BioSystems pathway for CDKN2D Gene

SIGNOR curated interactions for CDKN2D Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDKN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8741839
GO:0000082 G1/S transition of mitotic cell cycle IDA 10208428
GO:0000731 DNA synthesis involved in DNA repair IMP 15750620
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IDA 10208428
genes like me logo Genes that share ontologies with CDKN2D: view

Drugs & Compounds for CDKN2D Gene

No Compound Related Data Available

Transcripts for CDKN2D Gene

mRNA/cDNA for CDKN2D Gene

Unigene Clusters for CDKN2D Gene

Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2D Gene

No ASD Table

Relevant External Links for CDKN2D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKN2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDKN2D Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2D Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for CDKN2D Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.8) and Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDKN2D Gene

Protein tissue co-expression partners for CDKN2D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDKN2D Gene:


SOURCE GeneReport for Unigene cluster for CDKN2D Gene:


Evidence on tissue expression from TISSUES for CDKN2D Gene

  • Blood(4.5)
  • Bone marrow(4.5)
  • Muscle(4.1)
  • Nervous system(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKN2D Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • integumentary
  • lymphatic
  • nervous
Head and neck:
  • brain
  • eye
  • head
  • skin
genes like me logo Genes that share expression patterns with CDKN2D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDKN2D Gene

Orthologs for CDKN2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDKN2D 34 35
  • 99.6 (n)
(Canis familiaris)
Mammalia CDKN2D 34
  • 87.93 (n)
(Bos Taurus)
Mammalia CDKN2D 34 35
  • 85.34 (n)
(Mus musculus)
Mammalia Cdkn2d 34 16 35
  • 81.73 (n)
(Monodelphis domestica)
Mammalia CDKN2D 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia CDKN2D 35
  • 59 (a)
(Anolis carolinensis)
Reptilia CDKN2D 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2d 34
  • 65.07 (n)
(Danio rerio)
Actinopterygii LOC100333252 34
  • 64.01 (n)
cdkn2d 35
  • 56 (a)
Species where no ortholog for CDKN2D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2D Gene

Gene Tree for CDKN2D (if available)
Gene Tree for CDKN2D (if available)

Paralogs for CDKN2D Gene

Paralogs for CDKN2D Gene

genes like me logo Genes that share paralogs with CDKN2D: view

Variants for CDKN2D Gene

Sequence variations from dbSNP and Humsavar for CDKN2D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000006425 -- 10,566,702(+) CAGCC(-/GGCCAA)GGCCA upstream-variant-2KB, cds-indel
rs1000122204 -- 10,570,041(+) TTTTT(C/G)TTTGT upstream-variant-2KB
rs1000445138 -- 10,568,792(+) CGTCC(C/G)GGCTC intron-variant, utr-variant-5-prime
rs1000577364 -- 10,570,212(+) TTAAA(C/T)CTTTT upstream-variant-2KB
rs1000809294 -- 10,570,238(+) CTGAC(C/T)AGATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDKN2D Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897
nsv833745 CNV loss 17160897

Variation tolerance for CDKN2D Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKN2D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN2D Gene

Disorders for CDKN2D Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDKN2D Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
malignant melanoma, somatic
  • familial melanoma
deafness, autosomal recessive 68
  • autosomal recessive nonsyndromic deafness 68
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDKN2D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDKN2D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2D Gene

Publications for CDKN2D Gene

  1. Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. (PMID: 8575754) Okuda T. … Downing J.R. (Genomics 1995) 2 3 4 22 64
  2. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato E.M. … Pharoah P.D. (Breast Cancer Res. 2008) 3 22 46 64
  3. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 22 46 64
  4. Mutation testing in melanoma families: INK4A, CDK4 and INK4D. (PMID: 10390011) Newton Bishop J.A. … Bishop D.T. (Br. J. Cancer 1999) 3 4 22 64
  5. Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). (PMID: 9782052) Baumgartner R. … Holak T.A. (Structure 1998) 3 4 22 64

Products for CDKN2D Gene

Sources for CDKN2D Gene

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