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CDKN2C Gene

protein-coding   GIFtS: 64
GCID: GC01P051427

Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits CDK4)

  See CDKN2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits CDK4)1 2     Cyclin-Dependent Kinase 6 Inhibitor P182
p18-INK62 3     p182
INK4C2 5     p18-INK4C2
CDK6 Inhibitor P182     CDKN63
Cyclin-Dependent Inhibitor2     Cyclin-Dependent Kinase 6 Inhibitor3
Cyclin-Dependent Kinase 4 Inhibitor C2     p18-INK4c3

External Ids:    HGNC: 17891   Entrez Gene: 10312   Ensembl: ENSG000001230807   OMIM: 6033695   UniProtKB: P427733   

Export aliases for CDKN2C gene to outside databases

Previous GC identifers: GC01P051060 GC01P050315 GC01P050784 GC01P050796 GC01P051138 GC01P049551


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKN2C Gene:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This
protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus
function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was
shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a
wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating
spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this
gene, which encode an identical protein, have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDKN2C Gene:
CDKN2C (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)) is a protein-coding gene. Diseases associated with CDKN2C include anaplastic oligodendroglioma, and oligodendroglioma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773
Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated
dependence on endogenous retinoblastoma protein RB

Gene Wiki entry for CDKN2C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN2C gene promoter:
         GR   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDKN2C promoter sequence
   Search Chromatin IP Primers for CDKN2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

CDKN2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P051427:  view genomic region     (about GC identifiers)

Start:
51,426,417 bp from pter      End:
51,440,309 bp from pter
Size:
13,893 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4 inhibitor C  
Size: 168 amino acids; 18127 Da
Subunit: Heterodimer of p18 with CDK6
6 PDB 3D structures from and Proteopedia for CDKN2C:
1BU9 (3D)        1G3N (3D)        1IHB (3D)        1MX2 (3D)        1MX4 (3D)        1MX6 (3D)    
Secondary accessions: Q8TB83

Explore the universe of human proteins at neXtProt for CDKN2C: NX_P42773

Explore proteomics data for CDKN2C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDKN2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001253.1  NP_523240.1  

    ENSEMBL proteins: 
     ENSP00000262662   ENSP00000360826   ENSP00000379452  
    Reactome Protein details: P42773

    CDKN2C Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CDKN2C

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P42773

    ProtoNet protein and cluster: P42773

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773
    Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with CDKN2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN2C_HUMAN, P42773
    Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated
    dependence on endogenous retinoblastoma protein RB

         Genatlas biochemistry entry for CDKN2C:
    cyclin dependent kinase 6 (CDK6),inhibitor p18,regulator of cell cycle,passage through the G1 checkpoint,altered
    in a low fraction of oligodendroglial tumors

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IDA8001816
    GO:0005515protein binding IPI18394558
    GO:0019901protein kinase binding IPI8001816
         
    Find genes that share ontologies with CDKN2C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDKN2C:
     Paclitaxel antagonistic effect 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdkn2c):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     nervous system  renal/urinary system  reproductive system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with CDKN2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDKN2C: Cdkn2ctm1Yxi Cdkn2ctm1Bbd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKN2C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN2C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN2C

    miRNA
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    miRTarBase miRNAs that target CDKN2C:
    hsa-mir-34a-5p (MIRT025585)

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    4 qRT-PCR Assays for microRNAs that regulate CDKN2C:
    hsa-miR-3163 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDKN2C

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    Addgene plasmids for CDKN2C 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11800646
    GO:0005737cytoplasm IDA11800646
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDKN2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKN2C About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5GPCR Pathway
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with CDKN2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDKN2C
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for CDKN2C
        Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for CDKN2C
        G1 to S cell cycle control
    Signaling Pathways in Glioblastoma
    E2F transcription factor network

    4 Reactome Pathways for CDKN2C
        Oxidative Stress Induced Senescence
    Senescence-Associated Secretory Phenotype (SASP)
    Oncogene Induced Senescence
    Cyclin D associated events in G1


    3 Kegg Pathways  (Kegg details for CDKN2C):
        Cell cycle
    HTLV-I infection
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2C: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Lymphoma in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDKN2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDKN2C (P427731, 2, 3 ENSP000002626624) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-63749 I2D: score=5 STRING: ENSP00000269305
    APLP1P516932, 3MINT-63750 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-63755 I2D: score=5 
    COPS6Q7L5N12, 3MINT-63754 I2D: score=5 
    GDF9O603832, 3MINT-63748 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA8001816
    GO:0000082G1/S transition of mitotic cell cycle IDA10208428
    GO:0000278mitotic cell cycle TAS--
    GO:0007050cell cycle arrest IDA10208428
    GO:0008285negative regulation of cell proliferation IDA10208428

    Find genes that share ontologies with CDKN2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKN2C (CDN2C)

    2 Novoseek inferred chemical compound relationships for CDKN2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 0 2 8637234 (1), 8703847 (1)
    serine 0 2 8637234 (1), 8703847 (1)



    Find genes that share compounds with CDKN2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDKN2C gene (2 alternative transcripts): 
    NM_001262.2  NM_078626.2  

    Unigene Cluster for CDKN2C:

    Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
    Hs.525324  [show with all ESTs]
    Unigene Representative Sequence: AK091170
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262662(uc001csf.3) ENST00000371761(uc001csg.3) ENST00000396148

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    hsa-miR-3163 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2C 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CDKN2C
      QuantiFast Probe-based Assays in human, mouse, rat CDKN2C

    Additional mRNA sequence: 

    AF041248.1 AK021794.1 AK091170.1 BC000598.1 BC005041.1 BC016173.1 BC017036.1 CR450289.1 
    U17074.1 

    4 DOTS entries:

    DT.312436  DT.100786268  DT.100739628  DT.100840226 

    Selected AceView cDNA sequences (see all 156):

    BU509306 U17074 BF792127 AI421036 BM549119 AU279804 BM450858 AA482517 
    BM552303 BM727816 BC017036 NM_001262 AW510372 BU738383 BU660176 BM713150 
    BM474994 BM852457 BM904831 AA617663 BE886484 AW005436 BM712661 BE206507 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKN2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTGCAGA
    CDKN2C Expression
    About this image


    CDKN2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebellum
             Oligodendrocyte progenitor cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte progenitor cells
    CDKN2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKN2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525324

    UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773
    Tissue specificity: Highest levels found in skeletal muscle. Also found in pancreas and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2C: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Lymphoma in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN2C gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn2c1 , 5 cyclin-dependent kinase inhibitor 2C (p18, inhibits more1, 5 91.87(n)1
    92.26(a)1
      4 (51.32 cM)5
    125801  NM_007671.21  NP_031697.11 
     1096608765 
    chicken
    (Gallus gallus)
    Aves CDKN2C1 cyclin-dependent kinase inhibitor 2C (p18, inhibits more 77.49(n)
    80.89(a)
      429104  XM_004936780.1  XP_004936837.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDKN2C6
    cyclin-dependent kinase inhibitor 2C (p18, inhibit...
    67(a)
    1 ↔ 1
    4(113805102-113818121)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdkn2c1 cyclin-dependent kinase inhibitor 2C (p18, inhibits more 65.23(n)
    62.96(a)
      100144705  NM_001123460.1  NP_001116932.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdkn2c1 cyclin-dependent kinase inhibitor 2C (p18, inhibits more 53.95(n)
    53.95(a)
      555797  NM_001199994.1  NP_001186923.1 


    ENSEMBL Gene Tree for CDKN2C (if available)
    TreeFam Gene Tree for CDKN2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKN2C gene
    CDKN2A2  CDKN2B2  CDKN2D2  
    Selected SIMAP similar genes for CDKN2C using alignment to 3 protein entries:     CDN2C_HUMAN (see all proteins) (see all similar genes):
    CDKN2D    CDKN2B    CDKN2A    ANKRD2    ANKRD42    ANK2
    MIB1    PPP1R12B    ANKRD52    RAI14    ANK3    ANKRD29
    KIDINS220    DKFZp564M063    PSMD10    UACA    ANK1    ANKDD1B

    Find genes that share paralogs with CDKN2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKN2C (see all 151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0014904
    Breast cancer4--see VAR_0014902 A P mis40--------
    rs1472469021,2
    --51432375(+) ATGAAG/TCATAT 1 -- us2k10--------
    rs345942571,2
    C--51432411(+) ATGTT-/AAAAAA 1 -- us2k10--------
    rs557576401,2
    C--51432426(+) AAAAA-/A/AA  
            
    CCTTT
    1 -- us2k11NA 2
    rs1390778971,2
    --51432540(+) TTTTCC/TTTTTA 1 -- us2k10--------
    rs1857009131,2
    --51432643(+) TTATCA/GTAAGT 1 -- us2k10--------
    rs120631841,2
    C,F,H--51432657(+) CCTTAG/ATTGTT 1 -- us2k110Minor allele frequency- A:0.01NS EA NA 1398
    rs1132273471,2
    C,F--51432969(+) CGTCTG/ACATAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1899961221,2
    --51432981(+) TGTAAC/GAAAAA 1 -- us2k10--------
    rs1448937571,2
    C--51432986(+) GAAAA-/AGAGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDKN2C (51426417 - 51440309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDKN2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv225n71CNV Loss21882294
    nsv870748CNV Loss21882294
    dgv224n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): CDKN2C
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CDKN2C:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CDKN2C
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603369    OMIM disorders: --

    8 diseases for CDKN2C:    
    About MalaCards
    anaplastic oligodendroglioma    oligodendroglioma    chromosome 1p deletion    wermer syndrome
    familial melanoma    parathyroid adenoma    pancreatic endocrine tumors    myelodysplastic syndromes


    Find genes that share disorders with CDKN2C           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDKN2C gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaplastic oligodendroglioma 66.3 1 10515227 (1)
    retinoblastoma 65.5 7 15107819 (1), 15349907 (1), 16210085 (1), 15172750 (1) (see all 6)
    oligodendroglial tumors 65.3 2 10515227 (2)
    oligodendroglioma 56.2 11 11800646 (3), 10517502 (3), 10994011 (1)
    allelic loss 55.6 1 10517502 (1)
    tumors 45.1 63 10515227 (4), 14645011 (4), 11263500 (3), 8637248 (3) (see all 31)
    lymphoid neoplasm 44.6 1 8637248 (1)
    acute leukemia 39.2 2 8637234 (1), 8652384 (1)
    leukemogenesis 38.9 1 8628020 (1)
    somatic mutations 35 6 19401813 (2), 11263500 (1), 8938142 (1)

    Genetic Association Database (GAD): CDKN2C
    Human Genome Epidemiology (HuGE) Navigator: CDKN2C (14 documents)

    Export disorders for CDKN2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKN2C gene, integrated from 10 sources (see all 162):
    (articles sorted by number of sources associating them with CDKN2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)1, 2, 3, 9 Guan K.-L.... Xiong Y. (Genes Dev. 1994)
    2. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. (PubMed id 9636670)1, 2, 3, 9 Blais A.... Labrie C. (Biochem. Biophys. Res. Commun. 1998)
    3. Deletions of CDKN2C in multiple myeloma: biological and clinical implications. (PubMed id 18829482)1, 4, 9 Leone P.E....Morgan G.J. (Clin. Cancer Res. 2008)
    4. Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. (PubMed id 10074345)1, 2, 9 Li J....Tsai M.-D. (Biochemistry 1999)
    5. A p18 mutant defective in CDK6 binding in human breast cancer cells. (PubMed id 8840966)1, 2, 9 Lapointe J.... Labrie C. (Cancer Res. 1996)
    6. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4, 9 Goode E.L....Sellers T.A. (amp 2009)
    7. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. (PubMed id 19141585)1, 4, 9 Agarwal S.K....Marx S.J. (J. Clin. Endocrinol. Metab. 2009)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (Clin. Cancer Res. 2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    10. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (Carcinogenesis 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1031 HGNC: 1789 AceView: CDKN2C Ensembl:ENSG00000123080 euGenes: HUgn1031
    ECgene: CDKN2C Kegg: 1031 H-InvDB: CDKN2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDKN2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN2C Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn2c/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDKN2C gene:
    Search GeneIP for patents involving CDKN2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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