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CDKN2C Gene

protein-coding GIFtS: 63

GC01P051138

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CDKN6 ^³
INK4C ^¹, ², ⁵
OTTHUMP00000009730 ^²
OTTHUMP00000009731 ^²
OTTHUMP00000046546 ^²
p18 ^²
p18-INK4C ^²
p18-INK4c ^³
p18-INK6 ^³

Descriptions
CDK6 inhibitor p18 ^²
Cyclin-dependent kinase 6 inhibitor ^³
cyclin-dependent inhibitor ^²
cyclin-dependent kinase 4 inhibitor C ^²
cyclin-dependent kinase 6 inhibitor p18 ^²
cyclin-dependent kinase inhibitor 2C ^²
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) ^²

External Ids
HGNC: 1789¹
Entrez Gene: 1031²
UniProtKB: P42773³
Ensembl: ENSG00000123080⁷

Search outside databases for aliases for CDKN2C gene

Previous GC identifers: GC01P051060 GC01P050315 GC01P050784 GC01P050796

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CDKN2C:

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase

inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation

of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1

progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a

manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the

knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in

suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which

encode an identical protein, have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773

Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation

with a correlated dependence on endogenous retinoblastoma protein RB

Gene Wiki entry for CDKN2C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDKN2C gene

Entrez Gene cytogenetic band: 1p32 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p32.3

CDKN2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P051138: (about GC identifiers)

Start:	51,199,005 bp from pter
End:	51,212,897 bp from pter
Size:	13,893 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 4 inhibitor C

Size: 168 amino acids; 18127 Da

Subunit: Heterodimer of p18 with CDK6

PDB structures from and Proteopedia :

1BU9 (3D)

1G3N (3D)

1IHB (3D)

1MX2 (3D)

1MX4 (3D)

1MX6 (3D)

Secondary accessions: Q8TB83

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001253.1 NP_523240.1

ENSEMBL proteins:

ENSP00000360826 ENSP00000262662 ENSP00000379452

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (p18 INK4c)
	Human Recombinant Proteins from Abnova (CDKN2C)

OriGene Purified Recombinant Human Protein: CDKN2C

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11800646
GO:0005737	cytoplasm	IDA	11800646

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Antibodies for CDKN2C:

	Invitrogen Antibodies for CDKN2C
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CDKN2C
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDKN2C (p18INK4C)
	Antibodies from Abcam (p18 INK4c), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDKN2C)
	Novus Biologicals Antibodies for CDKN2C

Assays for CDKN2C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P42773

ProtoNet protein and cluster: P42773

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773

Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family

Similarity: Contains 4 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN2C)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001262

Applied Biosystems Silencer® siRNAs for CDKN2C

Sigma-Aldrich siRNA and siRNA Panels for CDKN2C

Sigma-Aldrich shRNA Panels and shRNA for CDKN2C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDKN2C
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001262
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001262
untagged cDNA clones in CMV expression vector (see all 2): NM_001262

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001262

UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773

Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation

with a correlated dependence on endogenous retinoblastoma protein RB

Genatlas biochemistry entry for CDKN2C:

cyclin dependent kinase 6 (CDK6),inhibitor p18,regulator of cell cycle,passage through the G1

checkpoint,altered in a low fraction of oligodendroglial tumors

15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cdkn2c):

	behavior/neurological	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging
nervous system	renal/urinary system	reproductive system	respiratory system	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IDA	8001816
GO:0005515	protein binding	IPI	17353931
GO:0019901	protein kinase binding	IPI	8001816

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for CDKN2C (Your Favorite Gene powered by Ingenuity)

Molecular Mechanisms of Cancer
Glioma Signaling

GeneDecks CDKN2C for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CDKN2C

5/33 Interacting proteins for CDKN2C (ENSP00000360826³ P42773^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 33 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK4	P11802¹	STRING (score=.999) EBI-711290, EBI-295644
CDK6	Q00534¹	STRING (score=.999) EBI-711290, EBI-295663
TP53	P04637²	STRING (score=.754) MINT-63749
APLP1	P51693²	MINT-63750
COPS6	Q7L5N1²	MINT-63754

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IDA	8001816
GO:0000082	G1/S transition of mitotic cell cycle	IDA	10208428
GO:0006917	induction of apoptosis	IDA	10208428
GO:0007049	cell cycle	IEA	--
GO:0007050	cell cycle arrest	IDA	10208428

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CDKN2C:

Inhibitor

Browse Tocris compounds for CDKN2C
1 Novoseek chemical compound relationship for CDKN2C gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	0.00	2	8637234 (1), 8703847 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN2C)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001262

Sigma-Aldrich siRNA and siRNA Panels for CDKN2C

Sigma-Aldrich shRNA Panels and shRNA for CDKN2C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001262 NM_078626

REFSEQ mRNAs for CDKN2C gene (2 alternative transcripts):

NM_001262.2 NM_078626.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001262 NM_078626

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001262
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001262
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001262

4 DOTS entries:

DT.312436 DT.100786268 DT.100739628 DT.100840226

24/156 AceView cDNA sequences (see all 156 ):

CR450289 BE206507 AW510372 BC017036 BM549119 AA617663 BM759636 BE855470

BM727816 AI421036 AA424974 BX353053 BM712661 CR612337 BM852457 AA482517

BM450858 BC005041 BE885012 BM552303 AU279804 BM762005 BM713150 BM928342

highest scoring ESTs for CDKN2C:

AF041248 AA022638 AA022649 AA285308 AA417884 AA424974 AA452363 AA482517 AA495966 AA617663

Unigene Clusters for CDKN2C:

Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Hs.525324 [show with all ESTs], Hs.716664 [show with all ESTs]

Unigene Representative Sequences: AK091170, NM_078626

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000371761 ENST00000262662 ENST00000396148

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CDKN2C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDKN2C

¹ / ² / ³

5 probe-sets matching CDKN2C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36053_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF041248	1.00	1.00	1.00	1
211792_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U17074	0.80	1.00	0.91	1
204159_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001262	0.60	1.00	0.82	1
211792_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204159_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDKN2C for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.525324 Hs.716664
Expression variation in blood from EXPOLDB for CDKN2C
UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773
Tissue specificity: Highest levels found in skeletal muscle. Also found in pancreas and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CDKN2C gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDKN2C¹	--	cyclin-dependent kinase inhibitor 2C (p18, inhibits more	94.44(n) 95.24(a)	475359 XM_844679.1 XP_849772.1
chimpanzee (Pan troglodytes)	CDKN2C¹	--	cyclin-dependent kinase inhibitor 2C (p18, inhibits more	100(n) 100(a)	469319 XM_001137894.1 XP_001137894.1
cow (Bos taurus)	CDKN2C¹	--	cyclin-dependent kinase inhibitor 2C (p18, inhibits more	95.04(n) 94.05(a)	505691 XM_582018.3 XP_582018.1
rat (Rattus norvegicus)	Cdkn2c¹	--	cyclin-dependent kinase inhibitor 2C (p18, inhibits more	91.87(n) 92.86(a)	54238 NM_131902.3 NP_571977.1
mouse (Mus musculus)	Cdkn2c^{1, 5}	4 (24.70 cM)⁵	cyclin-dependent kinase inhibitor 2C (p18, inhibits more^{1, 5}	91.87(n)¹ 92.26(a)¹	12580¹ NM_007671.2¹ NP_031697.1¹ AI323293⁵ AI853181⁵ (see all 14)

About this table Species with no ortholog for CDKN2C

ENSEMBL Gene Tree for CDKN2C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CDKN2C gene

CDKN2B² CDKN2D²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/69 NCBI SNPs in CDKN2C are shown (see all 69 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs12855^1,2	A,C,F,H,O	51212681(+)	`ACAGGC/TTTATG`	2	--	ut3¹ ese³		12	NS MN EU EA WA	1446
	rs3176445^1,2	C,F,H	51205748(+)	`CCCAGA/GTATTT`	1	--	ng5¹		5	NS EU EA WA	562
	rs3176447^1,2	C,F,H	51206275(+)	`TTTCAT/AAAAAT`	2	--	ng5¹ ese³		15	NS EU EA WA MN	1776
	rs3176446^1,2	C,F,H	51206250(+)	`TTCTTA/GCATAT`	2	--	ng5¹ ese³		5	NS EU EA WA	584
	rs3176450^1,2	C,F	51207185(+)	`GCCTGT/CAGGGG`	2	--	ut5¹ ng5¹		1	NS	164
--	rs3176451^1,2	F	51207191(+)	`AGGGGT/CGAAAG`	2	--	ng5¹ ut5¹ ese³		1	NS	166
	rs12063184^1,2	H	51205245(+)	`CCTTAG/ATTGTT`	1	--	ng5¹		4	EU EA WA	418
--	rs3176475^1,2	C	51212816(+)	`ATCTCA/GACACC`	2	--	ut3¹ ese³		1	NS	180
--	rs3176452^1,2	F	51207355(+)	`GACCGC/TGAGAG`	2	--	ut5¹ ng5¹ ese³		1	NS	172
	rs2500450^1,2	C,F,H	51212500(-)	`GCCCCG/ATTTGC`	2	N/N	syn¹ ese³		5	NS EU EA WA	584

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HapMap Linkage Disequilibrium images for CDKN2C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603369

UniProtKB/Swiss-Prot: CDN2C_HUMAN, P42773

Defects in CDKN2C are involved in tumor formation

10/32 Novoseek disease relationships for CDKN2C gene (see all 32 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anaplastic oligodendroglioma	67.49	1	10515227 (1)
oligodendroglial tumors	66.66	2	10515227 (2)
retinoblastoma	66.32	7	15107819 (1), 15349907 (1), 16210085 (1), 15172750 (1) (see all 6)
oligodendroglioma	57.29	11	11800646 (3), 10517502 (3), 10994011 (1)
allelic loss	51.51	1	10517502 (1)
lymphoid neoplasm	46.27	1	8637248 (1)
tumors	45.00	62	10515227 (4), 14645011 (4), 11263500 (3), 8637248 (3) (see all 30)
acute leukemia	40.30	2	8637234 (1), 8652384 (1)
leukemogenesis	40.11	1	8628020 (1)
lymphoblastic leukemia acute	32.42	4	8637234 (2), 7606004 (1), 14513284 (1)

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Genetic Association Database: CDKN2C
Human Genome Epidemiology Navigator: CDKN2C (9 documents)

(Possibly Related Articles in Doctor's Guide)
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EHA: Microarray Transcript Profiling Distinguishes Transient from Acute Type of Megakaryoblastic Leukaemia in Down Syndrome

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/136 PubMed articles for CDKN2C gene (see all 136 ):

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)^{1, 2, 3, 4} Guan K.-L.... Xiong Y. (1994)
Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. (PubMed id 9636670)^{1, 2, 3, 4} Blais A....Labrie C. (1998)
Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. (PubMed id 10074345)^{1, 3, 4} Li J....Tsai M.-D. (1999)
A p18 mutant defective in CDK6 binding in human breast cancer cells. (PubMed id 8840966)^{1, 3, 4} Lapointe J.... Labrie C. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. (PubMed id 11668523)^{3, 6} Kumar R....Hemminki K. (2001)
Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations. (PubMed id 9437433)^{3, 4} Venkataramani R.... Marmorstein R. (1998)
Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. (PubMed id 14645011)^{1, 3} Sanchez-Aguilera A....Garcia J.F. (2004)
Deletions of CDKN2C in multiple myeloma: biological and clinical implications. (PubMed id 18829482)^{1, 3} Leone P.E....Morgan G.J. (2008)
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c). (PubMed id 15107819)^{1, 3} Matsuzaki Y....Sakai T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1031	HGNC: 1789	AceView: CDKN2C	Ensembl:ENSG00000123080	euGenes: HUgn1031
ECgene: CDKN2C	H-InvDB: CDKN2C

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDKN2C	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn2c/

Licensable Technologies for CDKN2C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CDKN2C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDKN2C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for CDKN2C		Antibodies for CDKN2C
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDKN2C		Small molecules for CDKN2C
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies & Assays for CDKN2C (p18INK4C)

	Recombinant Proteins (p18 INK4c)
	Antibodies (p18 INK4c)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CDKN2C

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CDKN2C Gene at Home site.
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CDKN2C Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for CDKN2C

Summaries
for CDKN2C

Genomic Location
for CDKN2C

Proteins
for CDKN2C

Protein Domains/
Families
for CDKN2C

Gene Function
for CDKN2C

Pathways & Interactions
for CDKN2C

Drugs & Compounds
for CDKN2C

Transcripts
for CDKN2C

Expression
for CDKN2C

Orthologs
for CDKN2C

Paralogs
for CDKN2C

SNPs/Variants
for CDKN2C

Disorders & Mutations
for CDKN2C

Medical News
for CDKN2C

Publications
for CDKN2C

Search for CDKN2C

Genome Databases showing CDKN2C

Other Databases showing CDKN2C

Specialized Databases showing CDKN2C

Licensable Technologies
for CDKN2C

Services
for CDKN2C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDKN2C Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor CDKN2C

Summariesfor CDKN2C

Genomic Locationfor CDKN2C

Proteinsfor CDKN2C

Protein Domains/Familiesfor CDKN2C

Gene Functionfor CDKN2C

Pathways & Interactionsfor CDKN2C

Drugs & Compoundsfor CDKN2C

Transcriptsfor CDKN2C

Expression for CDKN2C

Orthologsfor CDKN2C

Paralogsfor CDKN2C

SNPs/Variantsfor CDKN2C

Disorders & Mutationsfor CDKN2C

Medical Newsfor CDKN2C

Publicationsfor CDKN2C

Search for CDKN2C

Genome Databases showing CDKN2C

Other Databases showing CDKN2C

Specialized Databases showing CDKN2C

Licensable Technologiesfor CDKN2C

Servicesfor CDKN2C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDKN2C

Summaries
for CDKN2C

Genomic Location
for CDKN2C

Proteins
for CDKN2C

Protein Domains/
Families
for CDKN2C

Gene Function
for CDKN2C

Pathways & Interactions
for CDKN2C

Drugs & Compounds
for CDKN2C

Transcripts
for CDKN2C

Expression
for CDKN2C

Orthologs
for CDKN2C

Paralogs
for CDKN2C

SNPs/Variants
for CDKN2C

Disorders & Mutations
for CDKN2C

Medical News
for CDKN2C

Publications
for CDKN2C

Licensable Technologies
for CDKN2C

Services
for CDKN2C