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Aliases for CDKN2C Gene

Aliases for CDKN2C Gene

  • Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits CDK4) 2 3
  • P18-INK4C 3 4
  • P18-INK6 3 4
  • Cyclin-Dependent Kinase 6 Inhibitor P18 3
  • Cyclin-Dependent Kinase 6 Inhibitor 4
  • Cyclin-Dependent Inhibitor 3
  • CDK6 Inhibitor P18 3
  • CDKN6 4
  • INK4C 3
  • P18 3

External Ids for CDKN2C Gene

Previous GeneCards Identifiers for CDKN2C Gene

  • GC01P051060
  • GC01P050315
  • GC01P050784
  • GC01P050796
  • GC01P051138
  • GC01P051427
  • GC01P049551

Summaries for CDKN2C Gene

Entrez Gene Summary for CDKN2C Gene

  • The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKN2C Gene

CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits CDK4)) is a Protein Coding gene. Diseases associated with CDKN2C include choriocarcinoma of the testis and multiple endocrine neoplasia 1. Among its related pathways are GPCR Pathway and ERK Signaling. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2B.

UniProtKB/Swiss-Prot for CDKN2C Gene

  • Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB

Gene Wiki entry for CDKN2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2C Gene

Genomics for CDKN2C Gene

Regulatory Elements for CDKN2C Gene

Transcription factor binding sites by QIAGEN in the CDKN2C gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDKN2C Gene

Chromosome:
1
Start:
50,960,745 bp from pter
End:
50,974,637 bp from pter
Size:
13,893 bases
Orientation:
Plus strand

Genomic View for CDKN2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2C Gene

Proteins for CDKN2C Gene

  • Protein details for CDKN2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42773-CDN2C_HUMAN
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor C
    Protein Accession:
    P42773
    Secondary Accessions:
    • Q8TB83

    Protein attributes for CDKN2C Gene

    Size:
    168 amino acids
    Molecular mass:
    18127 Da
    Quaternary structure:
    • Heterodimer of p18 with CDK6

    Three dimensional structures from OCA and Proteopedia for CDKN2C Gene

neXtProt entry for CDKN2C Gene

Proteomics data for CDKN2C Gene at MOPED

Post-translational modifications for CDKN2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2C Gene

Antibody Products

  • R&D Systems Antibodies for CDKN2C (p18INK4c/CDKN2C)
  • Cell Signaling Technology (CST) Antibodies for CDKN2C (CDKN2C)

No data available for DME Specific Peptides for CDKN2C Gene

Domains & Families for CDKN2C Gene

Gene Families for CDKN2C Gene

Protein Domains for CDKN2C Gene

Graphical View of Domain Structure for InterPro Entry

P42773

UniProtKB/Swiss-Prot:

CDN2C_HUMAN :
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with CDKN2C: view

Function for CDKN2C Gene

Molecular function for CDKN2C Gene

GENATLAS Biochemistry:
cyclin dependent kinase 6 (CDK6),inhibitor p18,regulator of cell cycle,passage through the G1 checkpoint,altered in a low fraction of oligodendroglial tumors
UniProtKB/Swiss-Prot Function:
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB

Gene Ontology (GO) - Molecular Function for CDKN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 8001816
GO:0005515 protein binding IPI 8840966
GO:0019901 protein kinase binding IPI 8001816
genes like me logo Genes that share ontologies with CDKN2C: view
genes like me logo Genes that share phenotypes with CDKN2C: view

Animal Models for CDKN2C Gene

MGI Knock Outs for CDKN2C:

Animal Model Products

CRISPR Products

miRNA for CDKN2C Gene

miRTarBase miRNAs that target CDKN2C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKN2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDKN2C Gene

Localization for CDKN2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2C Gene COMPARTMENTS Subcellular localization image for CDKN2C gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CDKN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11800646
GO:0005737 cytoplasm IDA 11800646
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDKN2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDKN2C Gene

Pathways & Interactions for CDKN2C Gene

genes like me logo Genes that share pathways with CDKN2C: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CDKN2C Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CDKN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8001816
GO:0000082 G1/S transition of mitotic cell cycle IDA 10208428
GO:0000278 mitotic cell cycle TAS --
GO:0007050 cell cycle arrest IDA 10208428
GO:0008285 negative regulation of cell proliferation IDA 10208428
genes like me logo Genes that share ontologies with CDKN2C: view

Drugs & Compounds for CDKN2C Gene

(10) Drugs for CDKN2C Gene - From: ApexBio and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AT7519 Investigational Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0
PHA-848125 Pharma CDK inhibitor,potent and ATP-competitive 0
genes like me logo Genes that share compounds with CDKN2C: view

Transcripts for CDKN2C Gene

mRNA/cDNA for CDKN2C Gene

Unigene Clusters for CDKN2C Gene

Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKN2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2C Gene

No ASD Table

Relevant External Links for CDKN2C Gene

GeneLoc Exon Structure for
CDKN2C
ECgene alternative splicing isoforms for
CDKN2C

Expression for CDKN2C Gene

mRNA expression in normal human tissues for CDKN2C Gene

Protein differential expression in normal tissues from HIPED for CDKN2C Gene

This gene is overexpressed in Ovary (22.9) and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKN2C Gene



SOURCE GeneReport for Unigene cluster for CDKN2C Gene Hs.525324

mRNA Expression by UniProt/SwissProt for CDKN2C Gene

P42773-CDN2C_HUMAN
Tissue specificity: Highest levels found in skeletal muscle. Also found in pancreas and heart
genes like me logo Genes that share expression patterns with CDKN2C: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDKN2C Gene

Orthologs for CDKN2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDKN2C 35
  • 95.04 (n)
  • 94.05 (a)
CDKN2C 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2C 35
  • 94.44 (n)
  • 95.24 (a)
CDKN2C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkn2c 35
  • 91.87 (n)
  • 92.26 (a)
Cdkn2c 16
Cdkn2c 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDKN2C 35
  • 100 (n)
  • 100 (a)
CDKN2C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkn2c 35
  • 91.87 (n)
  • 92.86 (a)
oppossum
(Monodelphis domestica)
Mammalia CDKN2C 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDKN2C 35
  • 77.49 (n)
  • 80.89 (a)
CDKN2C 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN2C 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2c 35
  • 65.23 (n)
  • 62.96 (a)
zebrafish
(Danio rerio)
Actinopterygii cdkn2c 35
  • 53.95 (n)
  • 53.95 (a)
cdkn2c 36
  • 48 (a)
OneToOne
Species with no ortholog for CDKN2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2C Gene

ENSEMBL:
Gene Tree for CDKN2C (if available)
TreeFam:
Gene Tree for CDKN2C (if available)

Paralogs for CDKN2C Gene

Paralogs for CDKN2C Gene

genes like me logo Genes that share paralogs with CDKN2C: view

Variants for CDKN2C Gene

Sequence variations from dbSNP and Humsavar for CDKN2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10028 -- 50,974,577(+) ACTTT(G/T)TTTTT utr-variant-3-prime
rs12855 -- 50,974,421(+) ACAGG(C/T)TTATG utr-variant-3-prime
rs1043141 -- 50,974,105(+) GAAGG(C/T)CACCT reference, synonymous-codon
rs2487827 -- 50,972,230(-) CTGTC(C/T)CTAAA intron-variant
rs2500450 -- 50,974,240(-) GCCCC(A/G)TTTGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CDKN2C Gene

Variant ID Type Subtype PubMed ID
dgv224n71 CNV Loss 21882294
dgv225n71 CNV Loss 21882294
nsv870748 CNV Loss 21882294

Variation tolerance for CDKN2C Gene

Residual Variation Intolerance Score: 48.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKN2C Gene

HapMap Linkage Disequilibrium report
CDKN2C
Human Gene Mutation Database (HGMD)
CDKN2C

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN2C Gene

Disorders for CDKN2C Gene

MalaCards: The human disease database

(10) MalaCards diseases for CDKN2C Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
choriocarcinoma of the testis
  • testicular choriocarcinoma
multiple endocrine neoplasia 1
  • multiple endocrine neoplasia type 1
angular cheilitis
  • cheilosis
anaplastic oligodendroglioma
  • oligodendroglial neoplasm
testicular malignant germ cell cancer
  • malignant germ cell tumor of testis
- elite association

Relevant External Links for CDKN2C

Genetic Association Database (GAD)
CDKN2C
Human Genome Epidemiology (HuGE) Navigator
CDKN2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDKN2C
genes like me logo Genes that share disorders with CDKN2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2C Gene

Publications for CDKN2C Gene

  1. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. (PMID: 9636670) Blais A. … Labrie C. (Biochem. Biophys. Res. Commun. 1998) 2 23 67
  2. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PMID: 8001816) Guan K.-L. … Xiong Y. (Genes Dev. 1994) 2 23 67
  3. The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation. (PMID: 18923142) Cheng F. … Zagon I.S. (Mol. Biol. Cell 2009) 23 67
  4. Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines. (PMID: 19509251) Eguchi T. … Kotani H. (Mol. Cancer Ther. 2009) 23 67
  5. Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling. (PMID: 18984860) BeA S. … Campo E. (Blood 2009) 23 67

Products for CDKN2C Gene

Sources for CDKN2C Gene

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