CDKN2C Gene

Aliases
for CDKN2C gene

Previous GC identifers: GC01P051060 GC01P050315 GC01P050784 GC01P050796 GC01P051138 GC01P049551

Summaries
for CDKN2C gene

Genomic Views
for CDKN2C gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_032977.9  

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDKN2C promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2C

CDKN2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P051427:  view genomic region     (about GC identifiers)

Proteins
for CDKN2C gene

6 PDB 3D structures from and Proteopedia for CDKN2C:

1BU9 (3D)        1G3N (3D)        1IHB (3D)        1MX2 (3D)        1MX4 (3D)        1MX6 (3D)    

Explore the universe of human proteins at neXtProt for CDKN2C: NX_P42773

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CDKN2C OriGene Protein Over-expression Lysate (see all 3): CDKN2C OriGene Custom Protein Services for CDKN2C
	GenScript Custom Purified and Recombinant Proteins Services for CDKN2C
	Novus Biologicals CDKN2C Proteins Novus Biologicals CDKN2C Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CDKN2C
	Uscn Proteins for CDKN2C

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CDKN2C (p18INK4c/CDKN2C)
	Cell Signaling Technology (CST) Antibodies for CDKN2C
	OriGene Antibodies (see all 9): CDKN2C OriGene Custom Antibody Services for CDKN2C
	GenScript Custom Superior Antibodies Services for CDKN2C
	Novus Biologicals CDKN2C Antibodies
	Search for Antibodies for CDKN2C at Abcam
	Uscn Antibodies for CDKN2C
	ThermoFisher Antibody for CDKN2C

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript CDKN2C-Activity-based Kinase Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDKN2C

Protein Domains /
Families
for CDKN2C gene

ProtoNet protein and cluster: P42773

Function
for CDKN2C gene

miRNA Products:		OriGene 3'-UTR Clone: CDKN2C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN2C
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN2C:
		hsa-miR-3163 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-4275
		SwitchGear 3'UTR luciferase reporter plasmid: CDKN2C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKN2C (see all 7) OriGene shRNA RFP: CDKN2C OriGene siRNA: CDKN2C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN2C

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CDKN2C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN2C (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN2C (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2C (NM_001262)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDKN2C
		Search LifeMap BioReagents cell lines for CDKN2C

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2C

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cdkn2c)

Pathways & Interactions
for CDKN2C gene

	Super-pathway	contained gene-specific pathways
1	Cyclins and Cell Cycle Regulation	Cyclins and Cell Cycle Regulation 1.00 Cyclin D associated events in G1 0.32 G1-S Phase Transition 0.67 G1 Phase 0.32
2	Cell Cycle	Cell Cycle 1.00 Cell Cycle, Mitotic 0.84
3	Cell cycle	Cell cycle 0.57 G1 to S cell cycle control 0.38
4	Cell Cycle / Checkpoint Control	Cell Cycle / Checkpoint Control 1.00
5	E2F transcription factor network	E2F transcription factor network 1.00

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN2C

	G1-S Phase Transition
	Cyclins and Cell Cycle Regulation
	Molecular Mechanisms of Cancer
	Pancreatic Adenocarcinoma

1 Cell Signaling Technology (CST) Pathway for CDKN2C

Cell Cycle / Checkpoint Control

3 BioSystems Pathways for CDKN2C

	Signaling Pathways in Glioblastoma
	G1 to S cell cycle control
	E2F transcription factor network

5        Reactome Pathways for CDKN2C

	G1 Phase
	Mitotic G1-G1/S phases
	Cell Cycle
	Cell Cycle, Mitotic
	Cyclin D associated events in G1

1         Kegg Pathway  (Kegg details for CDKN2C)

Cell cycle

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for CDKN2C gene

Transcripts
for CDKN2C gene

Expression
for CDKN2C gene

CDKN2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATTGCAGA

Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)			Cartilage, Neural Crest
	PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
	PureStem™ progenitor W8 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDKN2C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDKN2C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2C

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2C

Orthologs
for CDKN2C gene

Paralogs
for CDKN2C gene

Paralogs for CDKN2C gene

CDKN2A²  CDKN2B²  CDKN2D²  

18/39 SIMAP similar genes for CDKN2C using alignment to 3 protein entries:     CDN2C_HUMAN (see all proteins) (see all similar genes):

CDKN2D    CDKN2B    CDKN2A    ANKRD2    ANKRD42    ANK2

MIB1    PPP1R12B    ANKRD52    RAI14    ANKRD29    KIDINS220

ANK3    DKFZp564M063    PSMD10    UACA    ANK1    ANKK1

CDKN2C for paralogs           About GeneDecksing

Genomic Variants
for CDKN2C gene

10/125 NCBI SNPs in CDKN2C are shown (see all 125)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1472469021,2		--	51432375(+)	ATGAAG/TCATAT	1	--	us2k1		0	--	--	--	--
rs345942571,2	C	--	51432411(+)	ATGTT-/AAAAAA	1	--	us2k1		0	--	--	--	--
rs1390778971,2		--	51432540(+)	TTTTCC/TTTTTA	1	--	us2k1		0	--	--	--	--
rs1857009131,2		--	51432643(+)	TTATCA/GTAAGT	1	--	us2k1		0	--	--	--	--
rs120631841,2	C,F,H	--	51432657(+)	CCTTAG/ATTGTT	1	--	us2k1		10		NS EA NA	1398
rs1132273471,2		--	51432969(+)	CGTCTG/ACATAT	1	--	us2k1		1		CSA	2
rs1899961221,2		--	51432981(+)	TGTAAC/GAAAAA	1	--	us2k1		0	--	--	--	--
rs1448937571,2		--	51432986(+)	GAAAA-/AGAGAGT	1	--	us2k1		0	--	--	--	--
rs31764441,2	C	--	51433068(+)	TTTTTT/CCTCAA	1	--	us2k1 trp3		2		NS NA	148
rs1509116381,2		--	51433143(+)	CTCTTC/GCTGGA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDKN2C (51426417 - 51440309 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CDKN2C: --
Human Gene Mutation Database (HGMD): CDKN2C

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing CDKN2C: Glioma Oncogenes & Tumor Suppressor Genes 384HC

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN2C

DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2C

Disorders / Diseases
for CDKN2C gene

20/61 diseases for CDKN2C

10/32 Novoseek disease relationships for CDKN2C gene (see all 32)    About this table

Publications
for CDKN2C gene

PubMed articles for CDKN2C gene, integrated from 9 sources (see all 158): (articles sorted by number of sources associating them with CDKN2C)

Utopia: connect your pdf to the dynamic world of online information

1. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)^{1, 2, 3, 9} Guan K.-L.... Xiong Y. (1994)
2. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. (PubMed id 9636670)^{1, 2, 3, 9} Blais A....Labrie C. (1998)
3. Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. (PubMed id 10074345)^{1, 2, 9} Li J....Tsai M.-D. (1999)
4. A p18 mutant defective in CDK6 binding in human breast cancer cells. (PubMed id 8840966)^{1, 2, 9} Lapointe J.... Labrie C. (1996)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. (PubMed id 11668523)^{1, 4} Kumar R....Hemminki K. (2001)
7. Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations. (PubMed id 9437433)^{1, 2} Venkataramani R.... Marmorstein R. (1998)
8. Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. (PubMed id 14645011)^{1, 9} Sanchez-Aguilera A....Garcia J.F. (2004)
9. Expression of p18(INK4C) is Down-regulated in Human Pituitary Adenomas. (PubMed id 19401813)^{1, 9} Hossain M.G....Yoshimoto K. (2009)
10. Deletions of CDKN2C in multiple myeloma: biological and clinical implications. (PubMed id 18829482)^{1, 9} Leone P.E....Morgan G.J. (2008)

External Searches for CDKN2C gene

Genome Databases showing CDKN2C gene

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Products
for CDKN2C gene