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Aliases for CDKN2C Gene

Aliases for CDKN2C Gene

  • Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits CDK4) 2 3
  • P18-INK4C 3 4
  • P18-INK6 3 4
  • INK4C 3 6
  • Cyclin-Dependent Kinase 6 Inhibitor P18 3
  • Cyclin-Dependent Kinase 4 Inhibitor C 3
  • Cyclin-Dependent Kinase 6 Inhibitor 4
  • Cyclin-Dependent Inhibitor 3
  • CDK6 Inhibitor P18 3
  • CDKN6 4
  • P18 3

External Ids for CDKN2C Gene

Summaries for CDKN2C Gene

Entrez Gene Summary for CDKN2C Gene

  • The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKN2C Gene

CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits CDK4)) is a Protein Coding gene. Diseases associated with CDKN2C include anaplastic oligodendroglioma and chromosome 1p deletion. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2B.

UniProtKB/Swiss-Prot for CDKN2C Gene

  • Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB

Gene Wiki entry for CDKN2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2C Gene

Genomics for CDKN2C Gene

Genomic Location for CDKN2C Gene

Start:
50,960,745 bp from pter
End:
50,974,637 bp from pter
Size:
13,893 bases
Orientation:
Plus strand

Genomic View for CDKN2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2C Gene

Regulatory Elements for CDKN2C Gene

Transcription factor binding sites by QIAGEN in the CDKN2C gene promoter:

Proteins for CDKN2C Gene

  • Protein details for CDKN2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42773-CDN2C_HUMAN
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor C
    Protein Accession:
    P42773
    Secondary Accessions:
    • Q8TB83

    Protein attributes for CDKN2C Gene

    Size:
    168 amino acids
    Molecular mass:
    18127 Da
    Quaternary structure:
    • Heterodimer of p18 with CDK6

    Three dimensional structures from OCA and Proteopedia for CDKN2C Gene

neXtProt entry for CDKN2C Gene

Proteomics data for CDKN2C Gene at MOPED

Post-translational modifications for CDKN2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDKN2C Gene

Domains for CDKN2C Gene

Gene Families for CDKN2C Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for CDKN2C Gene

UniProtKB/Swiss-Prot:

CDN2C_HUMAN
Family:
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.:
    • P42773
Similarity:
  • Contains 4 ANK repeats.:
    • P42773
genes like me logo Genes that share domains with CDKN2C: view

Function for CDKN2C Gene

Molecular function for CDKN2C Gene

GENATLAS Biochemistry: cyclin dependent kinase 6 (CDK6),inhibitor p18,regulator of cell cycle,passage through the G1 checkpoint,altered in a low fraction of oligodendroglial tumors
UniProtKB/Swiss-Prot Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB

Gene Ontology (GO) - Molecular Function for CDKN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 8001816
GO:0005515 protein binding IPI 18394558
GO:0019901 protein kinase binding IPI 8001816
genes like me logo Genes that share ontologies with CDKN2C: view
genes like me logo Genes that share phenotypes with CDKN2C: view

Animal Models for CDKN2C Gene

MGI Knock Outs for CDKN2C:

miRNA for CDKN2C Gene

miRTarBase miRNAs that target CDKN2C

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDKN2C Gene

Localization for CDKN2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2C Gene COMPARTMENTS Subcellular localization image for CDKN2C gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CDKN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11800646
GO:0005737 cytoplasm IDA 11800646
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDKN2C: view

Pathways for CDKN2C Gene

genes like me logo Genes that share pathways with CDKN2C: view

Gene Ontology (GO) - Biological Process for CDKN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8001816
GO:0000082 G1/S transition of mitotic cell cycle IDA 10208428
GO:0000278 mitotic cell cycle TAS --
GO:0007050 cell cycle arrest IDA 10208428
GO:0008285 negative regulation of cell proliferation IDA 10208428
genes like me logo Genes that share ontologies with CDKN2C: view

Compounds for CDKN2C Gene

(2) Novoseek inferred chemical compound relationships for CDKN2C Gene

Compound -log(P) Hits PubMed IDs
threonine 0 2
serine 0 2
genes like me logo Genes that share compounds with CDKN2C: view

Transcripts for CDKN2C Gene

mRNA/cDNA for CDKN2C Gene

Unigene Clusters for CDKN2C Gene

Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2C Gene

No ASD Table

Relevant External Links for CDKN2C Gene

GeneLoc Exon Structure for
CDKN2C
ECgene alternative splicing isoforms for
CDKN2C

Expression for CDKN2C Gene

mRNA expression in normal human tissues for CDKN2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKN2C Gene

SOURCE GeneReport for Unigene cluster for CDKN2C Gene Hs.525324

mRNA Expression by UniProt/SwissProt for CDKN2C Gene

P42773-CDN2C_HUMAN
Tissue specificity: Highest levels found in skeletal muscle. Also found in pancreas and heart
genes like me logo Genes that share expressions with CDKN2C: view

Orthologs for CDKN2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN2C 36
  • 100 (n)
  • 100 (a)
CDKN2C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN2C 36
  • 95.04 (n)
  • 94.05 (a)
CDKN2C 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2C 36
  • 94.44 (n)
  • 95.24 (a)
CDKN2C 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkn2c 36
  • 91.87 (n)
  • 92.26 (a)
Cdkn2c 16
Cdkn2c 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDKN2C 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkn2c 36
  • 91.87 (n)
  • 92.86 (a)
chicken
(Gallus gallus)
Aves CDKN2C 36
  • 77.49 (n)
  • 80.89 (a)
CDKN2C 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN2C 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2c 36
  • 65.23 (n)
  • 62.96 (a)
zebrafish
(Danio rerio)
Actinopterygii cdkn2c 36
  • 53.95 (n)
  • 53.95 (a)
cdkn2c 37
  • 48 (a)
OneToOne
Species with no ortholog for CDKN2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2C Gene

ENSEMBL:
Gene Tree for CDKN2C (if available)
TreeFam:
Gene Tree for CDKN2C (if available)

Paralogs for CDKN2C Gene

Paralogs for CDKN2C Gene

genes like me logo Genes that share paralogs with CDKN2C: view

Variants for CDKN2C Gene

Sequence variations from dbSNP and Humsavar for CDKN2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12855 -- 50,974,421(+) ACAGG(C/T)TTATG utr-variant-3-prime
rs1043141 -- 50,974,105(+) GAAGG(C/T)CACCT reference, synonymous-codon
rs2487827 -- 50,972,230(-) CTGTC(C/T)CTAAA intron-variant
rs2500450 -- 50,974,240(-) GCCCC(A/G)TTTGC reference, synonymous-codon
rs3176444 -- 50,967,396(+) TTTTT(C/T)CTCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDKN2C Gene

Variant ID Type Subtype PubMed ID
dgv224n71 CNV Loss 21882294
dgv225n71 CNV Loss 21882294
nsv870748 CNV Loss 21882294

Relevant External Links for CDKN2C Gene

HapMap Linkage Disequilibrium report
CDKN2C
Human Gene Mutation Database (HGMD)
CDKN2C

Disorders for CDKN2C Gene

(32) Novoseek inferred disease relationships for CDKN2C Gene

Disease -log(P) Hits PubMed IDs
anaplastic oligodendroglioma 66.3 1
retinoblastoma 65.5 6
oligodendroglial tumors 65.3 2
oligodendroglioma 56.2 7
allelic loss 55.6 1

Relevant External Links for CDKN2C

Genetic Association Database (GAD)
CDKN2C
Human Genome Epidemiology (HuGE) Navigator
CDKN2C
genes like me logo Genes that share disorders with CDKN2C: view

No data available for UniProtKB/Swiss-Prot for CDKN2C Gene

Publications for CDKN2C Gene

  1. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PMID: 8001816) Guan K.-L. … Xiong Y. (Genes Dev. 1994) 2 3 4 23
  2. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. (PMID: 9636670) Blais A. … Labrie C. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. (PMID: 10074345) Li J. … Tsai M.-D. (Biochemistry 1999) 3 4 23
  4. A p18 mutant defective in CDK6 binding in human breast cancer cells. (PMID: 8840966) Lapointe J. … Labrie C. (Cancer Res. 1996) 3 4 23
  5. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 23 49

Products for CDKN2C Gene

Sources for CDKN2C Gene

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