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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDKN2B-AS1 Gene

RNA gene   GIFtS: 27
GCID: GC09P021994

CDKN2B Antisense RNA 1

(Previous name: CDKN2B antisense RNA 1 (non-protein coding))
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
CDKN2B Antisense RNA 11 2     P15 Antisense RNA1
ANRIL2 5     Prostate Cancer Associated Transcript 121
CDKN2BAS2 5     CDKN2B-AS2
Antisense RNA In The INK4 Locus1     NCRNA000892
CDKN2B Antisense RNA (Non-Protein Coding)1     PCAT122
CDKN2B Antisense RNA 1 (Non-Protein Coding)1     p15AS2
Non-Protein Coding RNA 891     

External Ids:    HGNC: 343411   Entrez Gene: 1000489122   Ensembl: ENSG000002404987   OMIM: 6131495   
ORGUL members:         
NONCODE14:n343083 n346507 n341663 n343082 n386487 see all 7      

Export aliases for CDKN2B-AS1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN2B-AS1 Gene:
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21 locus, which is the strongest
genetic susceptibility locus for cardiovascular diseases, and also linked to several cancers, intracranial
aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and
glaucoma. Many disease-associated single-nucleotide polymorphisms in this locus affect the structure and
expression of this gene, suggesting that modulation of this gene expression mediates disease susceptibility. This
gene interacts with both polycomb repressive complex-1 (PRC1) and -2 (PRC2), and may function as a regulator for
epigenetic transcriptional repression. Multiple alternatively spliced transcript variants have been generated
from this gene, and all of them are long non-coding RNAs. It has been found that some of splice variants are
tissue specific, and different splice variants may have distinct roles in cell physiology. (provided by RefSeq,
Jun 2012)

GeneCards Summary for CDKN2B-AS1 Gene: 
CDKN2B-AS1 (CDKN2B antisense RNA 1) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with CDKN2B-AS1 include intracranial aneurysm, and endometriosis.

Gene Wiki entry for CDKN2B-AS1 (CDKN2BAS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDKN2B-AS1
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.3   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21.3

CDKN2B-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2B-AS1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P021994:  view genomic region     (about GC identifiers)

Start:
21,994,777 bp from pter      End:
22,121,096 bp from pter
Size:
126,320 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CDKN2B-AS1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDKN2B-AS1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDKN2B-AS1

Search CenterWatch for drugs/clinical trials and news about CDKN2B-AS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for CDKN2B-AS1:

CDKN2B antisense RNA 1
Hs.493614  [show with all ESTs]
Unigene Representative Sequence: NR_003529
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000468603 ENST00000584351(uc010miw.1) ENST00000583719(uc022bef.1)
ENST00000580467(uc022bed.1 uc022bee.1 uc010mix.1) ENST00000585267
ENST00000580576 ENST00000428597(uc003zpm.3 uc022beg.1 uc022beh.1 uc022bei.1 uc022bej.1 uc022bek.1 uc022bel.1 uc022bem.1 uc022ben.1 uc010miz.3)
ENST00000582301 ENST00000584816 ENST00000584020 ENST00000577551 ENST00000584637
ENST00000581051 ENST00000582072 ENST00000455933 ENST00000421632 ENST00000422420


miRNA
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Primer
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Additional mRNA sequence: 

AB548314.1 BC038540.1 DQ485453.1 DQ485454.1 EU741058.1 NR_003529.3 NR_047532.1 NR_047533.1 
NR_047534.1 NR_047535.1 NR_047536.1 NR_047537.1 NR_047538.1 NR_047539.1 NR_047540.1 NR_047541.1 
NR_047542.1 NR_047543.1 

4 DOTS entries:

DT.70102474  DT.100008880  DT.444664  DT.75175573 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for CDKN2B-AS1:none

CDKN2B-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATCCTCAT
CDKN2B-AS1 Expression
About this image


Genevestigator expression for CDKN2B-AS1

SOURCE GeneReport for Unigene cluster: Hs.493614
    SABiosciences Custom PCR Arrays for CDKN2B-AS1
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B-AS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for CDKN2B-AS1 (if available)
TreeFam Gene Tree for CDKN2B-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/2816 SNPs in CDKN2B-AS1 are shown (see all 2816)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2009593861,2
--21959894(+) CCTTT-/TATGGGT 13 -- int10--------
rs1820545601,2
--21996534(+) TTTCTG/TTATAG 13 -- int10--------
rs351588951,2
C,F--21996624(+) GATCCTT/-TTATG 13 -- int13Minor allele frequency- -:0.41NA EA 22
rs1136468861,2
C,F--21996646(+) TGCACCT/-ATGCC 13 -- int12Minor allele frequency- -:0.30CSA EA 20
rs1905648961,2
C--21996647(+) GCACCC/TATGCC 13 -- int10--------
rs760374471,2
C,F--21996712(+) GGGGGG/ACATTA 13 -- int11Minor allele frequency- A:0.04EA 120
rs736528161,2
C,F--21996780(+) AAAACG/AATGTC 13 -- int13Minor allele frequency- A:0.15WA CSA 121
rs736528171,2
C,F--21996835(+) GGGAGC/AGGTGA 13 -- int13Minor allele frequency- A:0.14WA CSA 121
rs736528181,2
C--21996863(+) ACAATG/ATAACT 13 -- int13Minor allele frequency- A:0.15WA CSA 121
rs1173079631,2
C,F--21996930(+) TTGAAG/ATCGCT 13 -- int11Minor allele frequency- A:0.01NA 120

HapMap Linkage Disequilibrium report for CDKN2B-AS1 (21994777 - 22121096 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/12 variations for CDKN2B-AS1 (see all 12):    About this table     
Variant IDTypeSubtypePubMed ID
esv1998859CNV Deletion18987734
esv2738282CNV Deletion23290073
esv2589724CNV Deletion19546169
dgv1306e201CNV Deletion23290073
esv1002544CNV Insertion20482838
nsv416308CNV Loss16902084
nsv892746CNV Loss21882294
nsv8426CNV Loss18304495
nsv824877CNV Loss20364138
nsv892748CNV Loss21882294


Human Gene Mutation Database (HGMD): CDKN2B-AS1
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613149    OMIM disorders: --

20/21 diseases for CDKN2B-AS1 (see all 21):    About MalaCards
intracranial aneurysm    endometriosis    periodontitis    glaucoma
neurofibroma    gigantism    neurofibromatosis    alzheimer's disease
open-angle glaucoma    abdominal aortic aneurysm    coronary heart disease    aortic aneurysm
intrahepatic cholangiocarcinoma    cholangiocarcinoma    nasopharyngitis    acute lymphoblastic leukemia
lymphoblastic leukemia    myocardial infarction    atherosclerosis    melanoma


CDKN2B-AS1 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Export disorders for CDKN2B-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CDKN2B-AS1 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with CDKN2B-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by th e ATM-E2F1 signaling pathway. (PubMed id 23416462)1, 3 Wan G....Lu X. (2013)
  2. Genome-wide association study identifies susceptibili ty loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. (PubMed id 21532571)1, 3 Burdon K.P....Craig J.E. (2011)
  3. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (PubMed id 18048406)1, 3 Broadbent H.M....Watkins H. (2008)
  4. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. (PubMed id 17440112)1, 3 Pasmant E....Bieche I. (2007)
  5. The large non-coding RNA ANRIL, which is associated wi th atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1 , VAMP3 and C11ORF10. (PubMed id 23813974)1 Bochenek G....Schaefer A.S. (2013)
  6. A genome-wide association study of a coronary artery d isease risk variant. (PubMed id 23364394)1 Lee J.Y....Lee J.Y. (2013)
  7. Genome-wide association study of coronary and aortic c alcification implicates risk loci for coronary artery disease and myocardial inf arction. (PubMed id 23561647)1 van Setten J....de Bakker P.I. (2013)
  8. An Italian association study and meta-analysis with pr evious GWAS confirm WNT4, CDKN2BAS and FN1 as the first identified susceptibilit y loci for endometriosis. (PubMed id 23142796)1 Pagliardini L....Di Blasio A.M. (2013)
  9. Resequencing and clinical associations of the 9p21.3 r egion: a comprehensive investigation in the Framingham heart study. (PubMed id 23315372)1 Johnson A.D....O'Donnell C.J. (2013)
  10. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100048912 HGNC: 34341 Ensembl:ENSG00000240498 euGenes: HUgn100048912 ECgene: CDKN2B-AS1
H-InvDB: CDKN2B-AS1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CDKN2B-AS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CDKN2B-AS1 gene:
Search GeneIP for patents involving CDKN2B-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search LifeMap BioReagents cell lines for CDKN2B-AS1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B-AS1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CDKN2B-AS1
 Browse SwitchGear Promoter luciferase reporter plasmids for CDKN2B-AS1
 Search ThermoFisher Antibodies for CDKN2B-AS1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B-AS1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CDKN2B-AS1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDKN2B-AS1
Customized:
 lentivirus for stable overexpression
 lentivirus expression plasmids for stable overexpression
 adenovirus for overexpression
 Search LSBio for Antibodies for CDKN2B-AS1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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