CDKN2B-AS1 Gene
RNA gene GIFtS: 27
GCID: GC09P021994
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CDKN2B antisense RNA 1(Previous name: CDKN2B antisense RNA 1 (non-protein coding) )
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Aliases
for CDKN2B-AS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
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| CDKN2B Antisense RNA 11 2 | | NCRNA000891 2 | | ANRIL1 2 5 | | P15AS1 | | CDKN2BAS1 2 5 | | RP11-145E5.41 | | CDKN2B-AS1 2 | | CDKN2B Antisense RNA 1 (Non-Protein Coding)1 |
| External Ids: | HGNC: 343411 | Entrez Gene: 1000489122 | Ensembl: ENSG000002404987 | OMIM: 6131495 | | ORGUL members: | |
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| NONCODE:n343082 n386487 n343083 n341663 | |
Export aliases for CDKN2B-AS1 gene to outside databases
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Summaries
for CDKN2B-AS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for CDKN2B-AS1:
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21 locus, which is the strongest geneticsusceptibility locus for cardiovascular diseases, and also linked to several cancers, intracranial aneurysm, type-2diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Manydisease-associated single-nucleotide polymorphisms in this locus affect the structure and expression of this gene,suggesting that modulation of this gene expression mediates disease susceptibility. This gene interacts with bothpolycomb repressive complex-1 (PRC1) and -2 (PRC2), and may function as a regulator for epigenetic transcriptionalrepression. Multiple alternatively spliced transcript variants have been generated from this gene, and all of them arelong non-coding RNAs. It has been found that some of splice variants are tissue specific, and different splicevariants may have distinct roles in cell physiology. (provided by RefSeq, Jun 2012)
Gene Wiki entry for CDKN2B-AS1 (CDKN2BAS)
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Genomic Views
for CDKN2B-AS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CDKN2B-AS1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDKN2B-AS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B-AS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p21.3 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p21.3CDKN2B-AS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P021994: view genomic region
(about GC identifiers)
Start:
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21,994,777 bp from pter |
End:
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22,121,096 bp from pter |
Size:
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126,320 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
- n343083
- n386487
- n343082
- n341663
21994789 22057943 22121096 chr9
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Proteins
for CDKN2B-AS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for CDKN2B-AS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for CDKN2B-AS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B-AS1 |
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Pathways & Interactions
for CDKN2B-AS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDKN2B-AS1
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Drugs & Compounds
for CDKN2B-AS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDKN2B-AS1
Search CenterWatch for drugs/clinical trials and news about CDKN2B-AS1 
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Transcripts
for CDKN2B-AS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for CDKN2B-AS1: CDKN2B antisense RNA 1 Hs.493614 [show with all ESTs]Unigene Representative Sequence: NR_00352917 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468603 ENST00000584351(uc010miw.1) ENST00000583719(uc022bef.1)
ENST00000580467(uc022bed.1 uc022bee.1 uc010mix.1) ENST00000585267
ENST00000580576 ENST00000428597(uc003zpm.3 uc022beg.1 uc022beh.1 uc022bei.1 uc022bej.1 uc022bek.1 uc022bel.1 uc022bem.1 uc022ben.1 uc010miz.3)
ENST00000582301 ENST00000584816 ENST00000584020 ENST00000577551 ENST00000584637
ENST00000581051 ENST00000582072 ENST00000455933 ENST00000421632 ENST00000422420
Additional cDNA sequence: AB548314.1 BC038540.1 DQ485453.1 DQ485454.1 EU741058.1 NR_003529.3 NR_047532.1 NR_047533.1 NR_047534.1 NR_047535.1 NR_047536.1 NR_047537.1 NR_047538.1 NR_047539.1 NR_047540.1 NR_047541.1 NR_047542.1 NR_047543.1 4 DOTS entries: DT.70102474 DT.100008880 DT.444664 DT.75175573
GeneLoc Exon Structure
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Expression
for CDKN2B-AS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for CDKN2B-AS1:none
CDKN2B-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATCCTCAT
About this image
Genevestigator expression for CDKN2B-AS1
SOURCE GeneReport for Unigene cluster: Hs.493614
SABiosciences Custom PCR Arrays for CDKN2B-AS1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CDKN2B-AS1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B-AS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B-AS1 |
Orthologs
for CDKN2B-AS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for CDKN2B-AS1 (if available)
TreeFam Gene Tree for CDKN2B-AS1 (if available) |
Paralogs
for CDKN2B-AS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for CDKN2B-AS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CDKN2B-AS1 (21994777 - 22121096 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDKN2B-AS1: --
Human Gene Mutation Database (HGMD): CDKN2B-AS1
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CDKN2B-AS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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CDKN2B-AS1 for disorders About GeneDecksing
OMIM gene information: 613149
OMIM disorders: --
18  diseases for CDKN2B-AS1: About MalaCardsintracranial aneurysm glaucoma periodontitis endometriosis
open-angle glaucoma alzheimer's disease coronary heart disease intrahepatic cholangiocarcinoma
myocardial infarction gigantism neurofibromatosis cholangiocarcinoma
nasopharyngitis melanoma acute lymphoblastic leukemia atherosclerosis
lymphoblastic leukemia leukemia
Export disorders for CDKN2B-AS1 gene to outside databases
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Publications
for CDKN2B-AS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDKN2B-AS1 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with CDKN2B-AS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Long non-coding RNA ANRIL (CDKN2B-AS) is induced by th e ATM-E2F1 signaling pathway. (PubMed id 23416462)1, 3 Wan G....Lu X. (2013)
- Genome-wide association study identifies susceptibili ty loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. (PubMed id 21532571)1, 3 Burdon K.P....Craig J.E. (2011)
- Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (PubMed id 18048406)1, 3 Broadbent H.M....Watkins H. (2008)
- Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. (PubMed id 17440112)1, 3 Pasmant E....Bieche I. (2007)
- Recent studies of the human chromosome 9p21 locus, whi ch is associated with atherosclerosis in human populations. (PubMed id 22258902)1 Holdt L.M. and Teupser D. (2012)
- Intronic RNAs mediate EZH2 regulation of epigenetic ta rgets. (PubMed id 22659877)1 Guil S....Esteller M. (2012)
- Variants on chromosome 9p21.3 correlated with ANRIL ex pression contribute to stroke risk and recurrence in a large prospective stroke population. (PubMed id 22034006)1 Zhang W....Hui R. (2012)
- Association between chromosome 9p21 variants and the a nkle-brachial index identified by a meta-analysis of 21 genome-wide association studies. (PubMed id 22199011)1 Murabito J.M....Kronenberg F. (2012)
- Genome-wide association study of coronary artery disea se in the Japanese. (PubMed id 21971053)1 Takeuchi F....Kato N. (2012)
- Common variants in CDKN2B-AS1 associated with optic-ne rve vulnerability of glaucoma identified by genome-wide association studies in J apanese. (PubMed id 22428042)1 Nakano M....Tashiro K. (2012)
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External Searches for CDKN2B-AS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CDKN2B-AS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CDKN2B-AS1 gene
(According to HUGE)
About This Section
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Specialized Databases showing CDKN2B-AS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CDKN2B-AS1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CDKN2B-AS1 gene:
Search GeneIP for patents involving CDKN2B-AS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDKN2B-AS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDKN2B-AS1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN2B-AS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B-AS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN2B-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B-AS1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B-AS1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B-AS1 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B-AS1 |
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