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Aliases for CDKN2B-AS1 Gene

Subcategory (RNA class) for CDKN2B-AS1 Gene

antisense

Quality Score for this RNA gene is

3

Aliases for CDKN2B-AS1 Gene

  • CDKN2B Antisense RNA 1 2 3
  • CDKN2B Antisense RNA 1 (Non-Protein Coding) 2 3
  • Prostate Cancer Associated Transcript 12 2 3
  • P15 Antisense RNA 2 3
  • CDKN2BAS 3 6
  • ANRIL 3 6
  • CDKN2B Antisense RNA (Non-Protein Coding) 2
  • Antisense Noncoding RNA In The INK4 Locus 3
  • Antisense RNA In The INK4 Locus 2
  • Non-Protein Coding RNA 89 2
  • NCRNA00089 3
  • CDKN2B-AS 3
  • PCAT12 3
  • P15AS 3

External Ids for CDKN2B-AS1 Gene

ORGUL Members for CDKN2B-AS1 Gene

Summaries for CDKN2B-AS1 Gene

Entrez Gene Summary for CDKN2B-AS1 Gene

  • This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

GeneCards Summary for CDKN2B-AS1 Gene

CDKN2B-AS1 (CDKN2B Antisense RNA 1) is a RNA Gene, and belongs to antisense RNA class. Diseases associated with CDKN2B-AS1 include intracranial aneurysm and endometriosis.

Gene Wiki entry for CDKN2B-AS1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2B-AS1 Gene

Genomics for CDKN2B-AS1 Gene

Genomic Location for CDKN2B-AS1 Gene

Start:
21,994,778 bp from pter
End:
22,121,097 bp from pter
Size:
126,320 bases
Orientation:
Plus strand

Genomic View for CDKN2B-AS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2B-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2B-AS1 Gene

No data available for Regulatory Elements for CDKN2B-AS1 Gene

Proteins for CDKN2B-AS1 Gene

Post-translational modifications for CDKN2B-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CDKN2B-AS1 Gene

Domains for CDKN2B-AS1 Gene

Gene Families for CDKN2B-AS1 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs
genes like me logo Genes that share domains with CDKN2B-AS1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for CDKN2B-AS1 Gene

Function for CDKN2B-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDKN2B-AS1 Gene

Localization for CDKN2B-AS1 Gene

No data available for Gene Ontology (GO) - Cellular Components for CDKN2B-AS1 Gene

Pathways for CDKN2B-AS1 Gene

SuperPathways for CDKN2B-AS1 Gene

No Data Available

Interacting Proteins for CDKN2B-AS1 Gene

Gene Ontology (GO) - Biological Process for CDKN2B-AS1 Gene

None

No data available for Pathways by source for CDKN2B-AS1 Gene

Compounds for CDKN2B-AS1 Gene

(1) PharmGKB related drug/compound annotations for CDKN2B-AS1 Gene

Drug/compound Annotation
"Antiinflammatory agents, non-steroids" CA
genes like me logo Genes that share compounds with CDKN2B-AS1: view

Transcripts for CDKN2B-AS1 Gene

mRNA/cDNA for CDKN2B-AS1 Gene

(18) Additional mRNA sequences :
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDKN2B-AS1 Gene

CDKN2B antisense RNA 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B-AS1 Gene

No ASD Table

Relevant External Links for CDKN2B-AS1 Gene

GeneLoc Exon Structure for
CDKN2B-AS1
ECgene alternative splicing isoforms for
CDKN2B-AS1

Expression for CDKN2B-AS1 Gene

mRNA expression in normal human tissues for CDKN2B-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2B-AS1 Gene

This gene is overexpressed in Colon - Transverse (23.6), Small Intestine - Terminal Ileum (9.8), and Pituitary (4.0).

SOURCE GeneReport for Unigene cluster for CDKN2B-AS1 Gene Hs.493614

genes like me logo Genes that share expressions with CDKN2B-AS1: view

Orthologs for CDKN2B-AS1 Gene

Evolution for CDKN2B-AS1 Gene

ENSEMBL:
Gene Tree for CDKN2B-AS1 (if available)
TreeFam:
Gene Tree for CDKN2B-AS1 (if available)

No data available for Orthologs for CDKN2B-AS1 Gene

Paralogs for CDKN2B-AS1 Gene

No data available for Paralogs for CDKN2B-AS1 Gene

Variants for CDKN2B-AS1 Gene

Sequence variations from dbSNP and Humsavar for CDKN2B-AS1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs490005 -- 22,020,494(-) ctctg(C/T)tggtg intron-variant
rs496892 -- 22,024,352(-) aatcc(A/G)ctagc intron-variant
rs504318 -- 22,024,024(-) ctcaa(A/T)aatca intron-variant
rs518394 -- 22,019,674(-) ACACA(C/G)tcctc intron-variant
rs523096 -- 22,019,130(-) caatg(C/T)tttcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN2B-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv8426 CNV Loss 18304495
nsv892745 CNV Gain 21882294
nsv892746 CNV Loss 21882294
nsv892747 CNV Gain 21882294
nsv824877 CNV Loss 20364138
nsv892748 CNV Loss 21882294
esv1998859 CNV Deletion 18987734
esv2738282 CNV Deletion 23290073
dgv1306e201 CNV Deletion 23290073
nsv416308 CNV Loss 16902084
esv1002544 CNV Insertion 20482838
esv2589724 CNV Deletion 19546169

Relevant External Links for CDKN2B-AS1 Gene

HapMap Linkage Disequilibrium report
CDKN2B-AS1
Human Gene Mutation Database (HGMD)
CDKN2B-AS1

Disorders for CDKN2B-AS1 Gene

genes like me logo Genes that share disorders with CDKN2B-AS1: view

No data available for UniProtKB/Swiss-Prot for CDKN2B-AS1 Gene

Publications for CDKN2B-AS1 Gene

  1. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (PMID: 18048406) Broadbent H.M. … Watkins H. (Hum. Mol. Genet. 2008) 2 3
  2. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. (PMID: 21532571) Burdon K.P. … Craig J.E. (Nat. Genet. 2011) 2 3
  3. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. (PMID: 23416462) Wan G. … Lu X. (Cell. Signal. 2013) 2 3
  4. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. (PMID: 17440112) Pasmant E. … BiA"che I. (Cancer Res. 2007) 2 3
  5. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. (PMID: 17463249) Zeggini E. … Hattersley A.T. (Science 2007) 3

Products for CDKN2B-AS1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CDKN2B-AS1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CDKN2B-AS1
    • Block miRNA regulation of CDKN2B-AS1 using miScript Target Protectors

    Sources for CDKN2B-AS1 Gene

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