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Aliases for CDKN2B-AS1 Gene

Subcategory (RNA class) for CDKN2B-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CDKN2B-AS1 Gene

  • CDKN2B Antisense RNA 1 2 3 5
  • CDKN2B Antisense RNA 1 (Non-Protein Coding) 2 3
  • Prostate Cancer Associated Transcript 12 2 3
  • P15 Antisense RNA 2 3
  • CDKN2B Antisense RNA (Non-Protein Coding) 2
  • Antisense Noncoding RNA In The INK4 Locus 3
  • Antisense RNA In The INK4 Locus 2
  • Non-Protein Coding RNA 89 2
  • NCRNA00089 3
  • CDKN2B-AS 3
  • CDKN2BAS 3
  • PCAT12 3
  • ANRIL 3
  • P15AS 3

External Ids for CDKN2B-AS1 Gene

Summaries for CDKN2B-AS1 Gene

Entrez Gene Summary for CDKN2B-AS1 Gene

  • This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

GeneCards Summary for CDKN2B-AS1 Gene

CDKN2B-AS1 (CDKN2B Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CDKN2B-AS1 include intracranial aneurysm and periodontitis.

Gene Wiki entry for CDKN2B-AS1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2B-AS1 Gene

Genomics for CDKN2B-AS1 Gene

Regulatory Elements for CDKN2B-AS1 Gene

Promoters for CDKN2B-AS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDKN2B-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDKN2B-AS1 Gene

Chromosome:
9
Start:
21,994,778 bp from pter
End:
22,121,097 bp from pter
Size:
126,320 bases
Orientation:
Plus strand

Genomic View for CDKN2B-AS1 Gene

Genes around CDKN2B-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2B-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2B-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2B-AS1 Gene

Proteins for CDKN2B-AS1 Gene

Post-translational modifications for CDKN2B-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CDKN2B-AS1 Gene

Domains & Families for CDKN2B-AS1 Gene

Gene Families for CDKN2B-AS1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDKN2B-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CDKN2B-AS1 Gene

Function for CDKN2B-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKN2B-AS1 Gene

Localization for CDKN2B-AS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2B-AS1 Gene COMPARTMENTS Subcellular localization image for CDKN2B-AS1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDKN2B-AS1 Gene

Pathways & Interactions for CDKN2B-AS1 Gene

SuperPathways for CDKN2B-AS1 Gene

No Data Available

Interacting Proteins for CDKN2B-AS1 Gene

Gene Ontology (GO) - Biological Process for CDKN2B-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDKN2B-AS1 Gene

Drugs & Compounds for CDKN2B-AS1 Gene

(1) Drugs for CDKN2B-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antiinflammatory agents, non-steroids Pharma 0
genes like me logo Genes that share compounds with CDKN2B-AS1: view

Transcripts for CDKN2B-AS1 Gene

mRNA/cDNA for CDKN2B-AS1 Gene

(18) Additional mRNA sequences :
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDKN2B-AS1 Gene

CDKN2B antisense RNA 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B-AS1 Gene

No ASD Table

Relevant External Links for CDKN2B-AS1 Gene

GeneLoc Exon Structure for
CDKN2B-AS1
ECgene alternative splicing isoforms for
CDKN2B-AS1

Expression for CDKN2B-AS1 Gene

mRNA expression in normal human tissues for CDKN2B-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2B-AS1 Gene

This gene is overexpressed in Colon - Transverse (x23.6), Small Intestine - Terminal Ileum (x9.8), and Pituitary (x4.0).

SOURCE GeneReport for Unigene cluster for CDKN2B-AS1 Gene Hs.493614

genes like me logo Genes that share expression patterns with CDKN2B-AS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDKN2B-AS1 Gene

Orthologs for CDKN2B-AS1 Gene

Evolution for CDKN2B-AS1 Gene

ENSEMBL:
Gene Tree for CDKN2B-AS1 (if available)
TreeFam:
Gene Tree for CDKN2B-AS1 (if available)

No data available for Orthologs for CDKN2B-AS1 Gene

Paralogs for CDKN2B-AS1 Gene

No data available for Paralogs for CDKN2B-AS1 Gene

Variants for CDKN2B-AS1 Gene

Sequence variations from dbSNP and Humsavar for CDKN2B-AS1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs496892 -- 22,024,352(-) aatcc(A/G)ctagc intron-variant
rs504318 -- 22,024,024(-) ctcaa(A/T)aatca intron-variant
rs597816 -- 22,021,173(-) atctg(A/G)tcttc intron-variant
rs598664 -- 22,027,552(-) TTTTT(A/G)GATGT intron-variant
rs599452 -- 22,027,403(-) CCTGT(C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN2B-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv8426 CNV Loss 18304495
nsv892745 CNV Gain 21882294
nsv892746 CNV Loss 21882294
nsv892747 CNV Gain 21882294
nsv824877 CNV Loss 20364138
nsv892748 CNV Loss 21882294
esv1998859 CNV Deletion 18987734
esv2738282 CNV Deletion 23290073
dgv1306e201 CNV Deletion 23290073
nsv416308 CNV Loss 16902084
esv1002544 CNV Insertion 20482838
esv2589724 CNV Deletion 19546169

Relevant External Links for CDKN2B-AS1 Gene

HapMap Linkage Disequilibrium report
CDKN2B-AS1
Human Gene Mutation Database (HGMD)
CDKN2B-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CDKN2B-AS1 Gene

Disorders for CDKN2B-AS1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CDKN2B-AS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
intracranial aneurysm
  • brain aneurysm
periodontitis
  • chronic pericementitis
aneurysm
  • aneurysms
endometriosis
laryngeal benign neoplasm
  • laryngeal tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDKN2B-AS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDKN2B-AS1
genes like me logo Genes that share disorders with CDKN2B-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2B-AS1 Gene

Publications for CDKN2B-AS1 Gene

  1. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. (PMID: 23416462) Wan G. … Lu X. (Cell. Signal. 2013) 2 3 67
  2. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. (PMID: 21532571) Burdon K.P. … Craig J.E. (Nat. Genet. 2011) 2 3
  3. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (PMID: 18048406) Broadbent H.M. … Watkins H. (Hum. Mol. Genet. 2008) 2 3
  4. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. (PMID: 17440112) Pasmant E. … BiA"che I. (Cancer Res. 2007) 2 3
  5. Abnormal expression patterns of WT1-as, MEG3 and ANRIL long non-coding RNAs in CD34+ cells from patients with primary myelofibrosis and their clinical correlations. (PMID: 24707949) Pennucci V. … Manfredini R. (Leuk. Lymphoma 2015) 3

Products for CDKN2B-AS1 Gene

Sources for CDKN2B-AS1 Gene

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