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CDKN2B Gene

protein-coding   GIFtS: 68
GCID: GC09M021992

Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)

  See CDKN2B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)1 2     CDK Inhibitory Protein2
MTS22 3 5     CDK4B Inhibitor2
Multiple Tumor Suppressor 22 3     Cyclin-Dependent Kinase 4 Inhibitor B2
MTS-22 3     Cyclin-Dependent Kinases 4 And 6 Binding Protein2
p14-INK4b2 3     p14_INK4B2
p15-INK4b2 3     P14_CDK Inhibitor2
INK4B2 5     P15 CDK Inhibitor2
P152 5     p15INK4b2
CDK4I2     p15_INK4B2
TP152     p15INK4B3

External Ids:    HGNC: 17881   Entrez Gene: 10302   Ensembl: ENSG000001478837   OMIM: 6004315   UniProtKB: P427723   

Export aliases for CDKN2B gene to outside databases

Previous GC identifers: GC09M022331 GC09M022204 GC09M021994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKN2B Gene:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in
a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4
or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth
regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically
induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively
spliced transcript variants of this gene, which encode distinct proteins, have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDKN2B Gene:
CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) is a protein-coding gene. Diseases associated with CDKN2B include thyroid lymphoma, and skin melanoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
cycle arrest

Gene Wiki entry for CDKN2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN2B gene promoter:
         PPAR-gamma1   Sp1   p53   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN2B promoter sequence
   Search Chromatin IP Primers for CDKN2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21

CDKN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021992:  view genomic region     (about GC identifiers)

Start:
22,002,902 bp from pter      End:
22,009,362 bp from pter
Size:
6,461 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4 inhibitor B  
Size: 138 amino acids; 14722 Da
Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6
Secondary accessions: O15125 Q6FI09
Alternative splicing: 2 isoforms:  P42772-1   P42772-2   

Explore the universe of human proteins at neXtProt for CDKN2B: NX_P42772

Explore proteomics data for CDKN2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDKN2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004927.2  NP_511042.1  

    ENSEMBL proteins: 
     ENSP00000276925   ENSP00000369487   ENSP00000445136  
    Reactome Protein details: P42772

    CDKN2B Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDKN2B

     
    Search eBioscience for Proteins for CDKN2B 

     
    antibodies-online proteins for CDKN2B (5 products) 

     
    antibodies-online peptides for CDKN2B

    CDKN2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN2B
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    antibodies-online antibodies for CDKN2B (85 products) 

    CDKN2B Assay Products:

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    antibodies-online kits for CDKN2B (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P42772

    ProtoNet protein and cluster: P42772

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with CDKN2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN2B_HUMAN, P42772
    Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
    cycle arrest

         Genatlas biochemistry entry for CDKN2B:
    cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1
    checkpoint,tightly linked and highly homolog to CDKN2A

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity NAS9230210
    GO:0005515protein binding IPI16169070
    GO:0019901protein kinase binding IPI8078588
         
    Find genes that share ontologies with CDKN2B           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDKN2B:
     Decreased cilium length  Decreased cilium length after   Decreased telomerase activity  Increased cell number in G2M,  

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdkn2b):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with CDKN2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDKN2B: Cdkn2btm1Bbd Cdkn2btm1Brn Cdkn2a/Cdkn2bCdkn2a/tm1Brn Cdkn2a/Cdkn2bCdkn2a/tm2Brn Cdkn2btm2Brn

       genOway: Develop your customized and physiologically relevant rodent model for CDKN2B

    miRNA
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    miRTarBase miRNAs that target CDKN2B:
    hsa-mir-375 (MIRT019955), hsa-mir-98-5p (MIRT027714), hsa-mir-374b-5p (MIRT016027)

    Block miRNA regulation of human, mouse, rat CDKN2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKN2B (see all 25):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDKN2B
    Predesigned siRNA for gene silencing in human, mouse, rat CDKN2B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2B (NM_004936)
    Sino Biological Human cDNA Clone for CDKN2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
    Addgene plasmids for CDKN2B 

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    ESI BIO PureStem Progenitor for CDKN2B: 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12122) for CDKN2B 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDN2B_HUMAN, P42772: Cytoplasm. Note=Also found in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA16943770
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDKN2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKN2B About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    3Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    4Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with CDKN2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDKN2B
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Pancreatic Adenocarcinoma

    3 GeneGo (Thomson Reuters) Pathways for CDKN2B
        Cell cycle Regulation of G1/S transition (part 1)
    Development Role of Activin A in cell differentiation and proliferation
    Development TGF-beta receptor signaling

    5 BioSystems Pathways for CDKN2B
        G1 to S cell cycle control
    Signaling Pathways in Glioblastoma
    Integrated Pancreatic Cancer Pathway
    Regulation of nuclear SMAD2/3 signaling
    Validated targets of C-MYC transcriptional repression


    5 Reactome Pathways for CDKN2B
        Oxidative Stress Induced Senescence
    Senescence-Associated Secretory Phenotype (SASP)
    Oncogene Induced Senescence
    Cyclin D associated events in G1
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


    Selected Kegg Pathways  (Kegg details for CDKN2B) (see all 7):
        FoxO signaling pathway
    Cell cycle
    TGF-beta signaling pathway
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2B (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDKN2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDKN2B (P427721, 2, 3 ENSP000002769254) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-711280,EBI-295644 MINT-8251348 I2D: score=6 STRING: ENSP00000257904
    CDK8P493363, ENSP000003709384I2D: score=1 STRING: ENSP00000370938
    CDK6Q005341, ENSP000002657344EBI-711280,EBI-295663 STRING: ENSP00000265734
    ZBTB17Q131053, ENSP000003648954I2D: score=1 STRING: ENSP00000364895
    MAGEA11P433643, ENSP000003473584I2D: score=4 STRING: ENSP00000347358
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA8078588
    GO:0000086G2/M transition of mitotic cell cycle IMP17553787
    GO:0000278mitotic cell cycle TAS--
    GO:0001889liver development IEA--
    GO:0006351transcription, DNA-templated TAS--

    Find genes that share ontologies with CDKN2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKN2B (CDN2B)

    Selected Novoseek inferred chemical compound relationships for CDKN2B gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methylthioadenosine 75.7 10 18163473 (1), 12661005 (1), 16618910 (1), 19272367 (1) (see all 7)
    5-aza-2'deoxycytidine 70.4 28 12351408 (3), 18718068 (3), 19881540 (2), 15015578 (2) (see all 12)
    sodium bisulfite 64.2 3 17369979 (1), 9808523 (1), 10637497 (1)
    tgf beta1 18.1 5 16871886 (2), 14693046 (1), 11082295 (1)
    5-methylcytosine 16.1 1 9808523 (1)
    o6-methylguanine 15.9 2 15197802 (1)
    retinoic acid 7.43 3 10896783 (1), 15839997 (1)
    pd 98,059 7.28 2 16322252 (1), 17513607 (1)
    arsenite 4.79 3 11877046 (3)
    azathioprine 2.25 1 15015578 (1)



    Find genes that share compounds with CDKN2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDKN2B gene (2 alternative transcripts): 
    NM_004936.3  NM_078487.2  

    Unigene Cluster for CDKN2B:

    Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
    Hs.72901  [show with all ESTs]
    Unigene Representative Sequence: NM_078487
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276925(uc003zpn.3 uc003zpo.3) ENST00000579591 ENST00000380142
    ENST00000539462(uc022beo.1)
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    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
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    eBioscience FlowRNA Probe Sets ( VA1-12122) for CDKN2B 

    Additional mRNA sequence: 

    AF004819.1 AF488409.1 AF488410.1 AF488411.1 AF488731.1 BC014469.1 BC018984.2 CR536529.1 
    L36844.1 U17075.1 

    5 DOTS entries:

    DT.40207564  DT.91660559  DT.121147154  DT.75102662  DT.95150832 

    Selected AceView cDNA sequences (see all 264):

    BM719878 BF000057 NM_078487 BM126144 AF488409 BM843979 CR604976 CB160611 
    CK904818 BM831598 AU279609 BM701855 CR536529 BQ002393 BM055160 N44213 
    AA826886 AF004819 BC014469 BG031050 BX502404 AW328497 NM_004936 AF488410 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for CDKN2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDKN2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCTGCTT
    CDKN2B Expression
    About this image


    CDKN2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Granulosa Cells Primary Follicle
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    CDKN2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKN2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72901

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2B (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN2B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn2b1 , 5 cyclin-dependent kinase inhibitor 2B (p15, inhibits more1, 5 84.37(n)1
    88.28(a)1
      4 (42.15 cM)5
    125791  NM_007670.41  NP_031696.11 
     893062895 
    chicken
    (Gallus gallus)
    Aves CDKN2B1 cyclin-dependent kinase inhibitor 2B (p15, inhibits more 70.03(n)
    63.87(a)
      395076  NM_204433.1  NP_989764.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    2(61354501-61364127)


    ENSEMBL Gene Tree for CDKN2B (if available)
    TreeFam Gene Tree for CDKN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKN2B gene
    CDKN2A2  CDKN2C2  CDKN2D2  
    10 SIMAP similar genes for CDKN2B using alignment to 4 protein entries:     CDN2B_HUMAN     Q8NIA6_HUMAN     K7PPU3_HUMAN     Q5ZEY8_HUMAN(see first protein):
    p15    CDKN2A    p14ARF    p16ink4a    CDKN2D    CDKN2C
    ANKRD54    TNKS2    ANKRD28    ANKRD65

    Find genes that share paralogs with CDKN2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKN2B (see all 211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0014894
    Lung adenocarcinoma4--see VAR_0014892 A V mis40--------
    VAR_0014884
    Lung adenocarcinoma4--see VAR_0014882 G E mis40--------
    rs1474873281,2
    --21997231(+) AATTAC/TAGAAT 2 -- ds50010--------
    rs726936181,2
    C--21997246(+) AAAAAA/GAAAAA 2 -- ds50010--------
    rs32179951,2
    C,F--21997326(-) ACTTAC/-ACTGA 2 -- ds50011Minor allele frequency- -:0.02NS 170
    rs1400639651,2
    --21997487(+) GGCGTC/TTGGGG 2 -- ds50010--------
    rs32179941,2
    C,F,H--21997633(-) CACCTA/GAGTGG 2 -- ds500120Minor allele frequency- G:0.07NS EA NA WA 2093
    rs1817364501,2
    --21997829(+) CAGGAA/CTCATG 2 -- ut310--------
    rs32179931,2
    C--21997938(-) CCACCT/CGGCAG 2 -- ut31 ese32Minor allele frequency- C:0.01NS NA 156
    rs32179921,2
    C,F,H--21997992(-) GTATTG/AAAATA 2 -- ut3130Minor allele frequency- A:0.34NS EA NA WA 3159

    HapMap Linkage Disequilibrium report for CDKN2B (22002902 - 22009362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDKN2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8426CNV Loss18304495
    nsv892748CNV Loss21882294
    nsv824877CNV Loss20364138
    nsv892746CNV Loss21882294
    nsv892745CNV Gain21882294
    nsv892747CNV Gain21882294

    Human Gene Mutation Database (HGMD): CDKN2B
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CDKN2B:
    Oncogenes & Tumor Suppressor Genes 384HC
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing CDKN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600431    OMIM disorders: --

    Selected diseases for CDKN2B (see all 23):    
    About MalaCards
    thyroid lymphoma    skin melanoma    laryngeal squamous cell carcinoma    multiple familial trichoepithelioma
    primary malignant lymphoma    anaplastic oligodendroglioma    adult acute lymphocytic leukemia    oligodendroglioma
    wermer syndrome    ewing's family of tumors    diffuse astrocytoma    coronary restenosis
    melanoma, malignant, somatic    pleomorphic xanthoastrocytoma    lymphoblastic lymphoma    anaplastic astrocytoma
    actinic keratosis    myelodysplastic syndromes    acute lymphocytic leukemia    glomus tumor

    1 disease from the University of Copenhagen DISEASES database for CDKN2B:
    Cancer

    Find genes that share disorders with CDKN2B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDKN2B gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 70.7 14 16140969 (1), 17513607 (1), 9058294 (1), 9327828 (1) (see all 13)
    tumors 68.2 350 7563186 (5), 11764089 (4), 8689637 (4), 9816033 (4) (see all 99)
    t-all 67.9 39 9041181 (5), 9399648 (4), 10778944 (4), 8630377 (2) (see all 15)
    myelodysplastic syndromes 66 21 17095538 (2), 9269757 (2), 9531610 (2), 11167795 (2) (see all 13)
    multiple tumors 64.3 3 8957063 (1), 9827724 (1), 9698532 (1)
    allelic imbalance 62.4 7 18564286 (1), 18712977 (1), 18331779 (1)
    lymphoblastic leukemia acute 61.2 29 7780130 (2), 7994022 (2), 8683987 (1), 8816064 (1) (see all 22)
    allelic loss 61.1 6 7780130 (1), 9501299 (1), 11874489 (1), 8855819 (1)
    primary tumor 60.1 12 7882348 (1), 8760309 (1), 9698478 (1), 8689636 (1) (see all 9)
    lymphoblastic leukemia acute childhood 58.2 14 9399648 (2), 9737691 (2), 8816064 (1), 12661005 (1) (see all 8)

    Genetic Association Database (GAD): CDKN2B
    Human Genome Epidemiology (HuGE) Navigator: CDKN2B (146 documents)

    Export disorders for CDKN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKN2B gene, integrated from 10 sources (see all 804):
    (articles sorted by number of sources associating them with CDKN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PubMed id 8078588)1, 2, 3, 9 Hannon G.J. and Beach D. (Nature 1994)
    2. Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)1, 4, 9 Soto MartA-nez J.L....LA^pez-Nevot M.A. (amp 2005)
    3. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (PubMed id 7882351)1, 2, 9 Okamoto A.... Harris C.C. (Cancer Res. 1995)
    4. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. (PubMed id 19141585)1, 4, 9 Agarwal S.K....Marx S.J. (J. Clin. Endocrinol. Metab. 2009)
    5. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. (PubMed id 17008550)1, 4, 9 Healy J....Sinnett D. (Blood 2007)
    6. MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. (PubMed id 19272367)1, 4, 9 Yang X.C....Wang X.F. (Clin. Biochem. 2009)
    7. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. (PubMed id 19690970)1, 4, 9 Chen J....Frazier M.L. (amp 2009)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (Clin. Cancer Res. 2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    10. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PubMed id 17928989)1, 4, 9 Horikoshi M....Kadowaki T. (Diabetologia 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1030 HGNC: 1788 AceView: CDKN2AandCDKN2B Ensembl:ENSG00000147883 euGenes: HUgn1030
    ECgene: CDKN2B Kegg: 1030 H-InvDB: CDKN2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDKN2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN2B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn2b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDKN2B gene:
    Search GeneIP for patents involving CDKN2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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