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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDKN2B Gene

protein-coding   GIFtS: 68
GCID: GC09M021992

Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)1 2     CDK Inhibitory Protein2
MTS22 3 5     CDK4B Inhibitor2
Multiple Tumor Suppressor 22 3     Cyclin-Dependent Kinase 4 Inhibitor B2
MTS-22 3     Cyclin-Dependent Kinases 4 And 6 Binding Protein2
p14-INK4b2 3     p14_INK4B2
p15-INK4b2 3     P14_CDK Inhibitor2
INK4B2 5     P15 CDK Inhibitor2
P152 5     p15INK4b2
CDK4I2     p15_INK4B2
TP152     p15INK4B3

External Ids:    HGNC: 17881   Entrez Gene: 10302   Ensembl: ENSG000001478837   OMIM: 6004315   UniProtKB: P427723   

Export aliases for CDKN2B gene to outside databases

Previous GC identifers: GC09M022331 GC09M022204 GC09M021994


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN2B Gene:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in
a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4
or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth
regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically
induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively
spliced transcript variants of this gene, which encode distinct proteins, have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDKN2B Gene: 
CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) is a protein-coding gene. Diseases associated with CDKN2B include acute lymphoblastic leukemia, childhood, and laryngeal squamous cell carcinoma, and among its related super-pathways are G1-S Phase Transition and Mitotic G1-G1/S phases. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
cycle arrest

Gene Wiki entry for CDKN2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKN2B gene promoter:
         PPAR-gamma1   Sp1   p53   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN2B promoter sequence
   Search SABiosciences Chromatin IP Primers for CDKN2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21

CDKN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021992:  view genomic region     (about GC identifiers)

Start:
22,002,902 bp from pter      End:
22,009,362 bp from pter
Size:
6,461 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4 inhibitor B  
Size: 138 amino acids; 14722 Da
Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6
Subcellular location: Cytoplasm. Note=Also found in the nucleus
Secondary accessions: O15125 Q6FI09
Alternative splicing: 2 isoforms:  P42772-1   P42772-2   

Explore the universe of human proteins at neXtProt for CDKN2B: NX_P42772

Explore proteomics data for CDKN2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42772

  • CDKN2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDKN2B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004927.2  NP_511042.1  

    ENSEMBL proteins: 
     ENSP00000276925   ENSP00000369487   ENSP00000445136  
    Reactome Protein details: P42772
    Human Recombinant Protein Products for CDKN2B: 
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    Novus Biologicals CDKN2B Protein
    Novus Biologicals CDKN2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDKN2B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18564286
    GO:0005737cytoplasm IDA16943770
    GO:0005829cytosol TAS--

    CDKN2B for ontologies           About GeneDecksing



    CDKN2B Antibody Products: 
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    Novus Biologicals CDKN2B Antibodies
    Abcam antibodies for CDKN2B
    Cloud-Clone Corp. Antibodies for CDKN2B 
    ThermoFisher Antibodies for CDKN2B
    LSBio Antibodies in human, mouse, rat for CDKN2B 

    Assay Products for CDKN2B: 
    EMD Millipore Kits and Assays for the Analysis of CDKN2B
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDKN2B 
    Cloud-Clone Corp. CLIAs for CDKN2B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P42772

    ProtoNet protein and cluster: P42772

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
    Similarity: Contains 4 ANK repeats


    CDKN2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN2B_HUMAN, P42772
    Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
    cycle arrest

         Genatlas biochemistry entry for CDKN2B:
    cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1
    checkpoint,tightly linked and highly homolog to CDKN2A

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity NAS9230210
    GO:0005515protein binding IPI16169070
    GO:0019901protein kinase binding IPI8078588
         
    CDKN2B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDKN2B:
     Decreased cilium length  Decreased cilium length after   Decreased telomerase activity  Increased cell number in G2M,  

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdkn2b):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system 
     tumorigenesis 

    CDKN2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDKN2B: Cdkn2btm1Bbd Cdkn2btm1Brn Cdkn2a/Cdkn2bCdkn2a/tm1Brn Cdkn2a/Cdkn2bCdkn2a/tm2Brn Cdkn2btm2Brn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDKN2B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDKN2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN2B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN2B 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN2B
    25 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN2B (see first 8):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    hsa-miR-3143 hsa-miR-330-3p hsa-miR-375 hsa-miR-3121-3p hsa-miR-556-3p hsa-miR-1290 hsa-miR-4324 hsa-miR-154
    hsa-miR-519c-3p hsa-miR-432 hsa-miR-519b-3p hsa-miR-33a* hsa-miR-2355-5p hsa-miR-582-5p hsa-miR-3913-5p hsa-miR-608
    hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for CDKN2B
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CDKN2B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for CDKN2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2B (NM_004936)
    Sino Biological Human cDNA Clone for CDKN2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
    Sirion Biotech Customized lentivirus for stable overexpression of CDKN2B 
                         Customized lentivirus expression plasmids for stable overexpression of CDKN2B 

    Cell Line
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    LifeMap BioReagents: cell line associated with CDKN2B: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDKN2B About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    3Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CDKN2B
        Development Role of Activin A in cell differentiation and proliferation
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN2B
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Pancreatic Adenocarcinoma

    3 GeneGo (Thomson Reuters) Pathways for CDKN2B
        Cell cycle Regulation of G1/S transition (part 1)
    Development Role of Activin A in cell differentiation and proliferation
    Development TGF-beta receptor signaling

    5 BioSystems Pathways for CDKN2B
        G1 to S cell cycle control
    Signaling Pathways in Glioblastoma
    Integrated Pancreatic Cancer Pathway
    Regulation of nuclear SMAD2/3 signaling
    Validated targets of C-MYC transcriptional repression


    5/11        Reactome Pathways for CDKN2B (see all 11)
        G1 Phase
    Generic Transcription Pathway
    Mitotic G1-G1/S phases
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Cell Cycle


    5/6         Kegg Pathways  (Kegg details for CDKN2B) (see all 6):
        Cell cycle
    TGF-beta signaling pathway
    HTLV-I infection
    Pathways in cancer
    Viral carcinogenesis


    CDKN2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for CDKN2B (P427721, 2, 3 ENSP000002769254) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-711280,EBI-295644 MINT-8251348 I2D: score=6 STRING: ENSP00000257904
    CDK8P493363, ENSP000003709384I2D: score=1 STRING: ENSP00000370938
    CDK6Q005341, ENSP000002657344EBI-711280,EBI-295663 STRING: ENSP00000265734
    ZBTB17Q131053, ENSP000003648954I2D: score=1 STRING: ENSP00000364895
    MAGEA11P433643, ENSP000003473584I2D: score=4 STRING: ENSP00000347358
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA8078588
    GO:0000086G2/M transition of mitotic cell cycle IMP17553787
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    CDKN2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDKN2B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDKN2B (CDN2B)

    10/19 Novoseek inferred chemical compound relationships for CDKN2B gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methylthioadenosine 75.7 10 18163473 (1), 12661005 (1), 16618910 (1), 19272367 (1) (see all 7)
    5-aza-2'deoxycytidine 70.4 28 12351408 (3), 18718068 (3), 19881540 (2), 15015578 (2) (see all 12)
    sodium bisulfite 64.2 3 17369979 (1), 9808523 (1), 10637497 (1)
    tgf beta1 18.1 5 16871886 (2), 14693046 (1), 11082295 (1)
    5-methylcytosine 16.1 1 9808523 (1)
    o6-methylguanine 15.9 2 15197802 (1)
    retinoic acid 7.43 3 10896783 (1), 15839997 (1)
    pd 98,059 7.28 2 16322252 (1), 17513607 (1)
    arsenite 4.79 3 11877046 (3)
    azathioprine 2.25 1 15015578 (1)

    Search CenterWatch for drugs/clinical trials and news about CDKN2B / CDN2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDKN2B gene (2 alternative transcripts): 
    NM_004936.3  NM_078487.2  

    Unigene Cluster for CDKN2B:

    Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
    Hs.72901  [show with all ESTs]
    Unigene Representative Sequence: NM_078487
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276925(uc003zpn.3 uc003zpo.3) ENST00000579591 ENST00000380142
    ENST00000539462(uc022beo.1)

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN2B (see all 25):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
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    OriGene qPCR primer pairs and template standards for CDKN2B
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B

    Additional mRNA sequence: 

    AF004819.1 AF488409.1 AF488410.1 AF488411.1 AF488731.1 BC014469.1 BC018984.2 CR536529.1 
    L36844.1 U17075.1 

    5 DOTS entries:

    DT.40207564  DT.91660559  DT.121147154  DT.75102662  DT.95150832 

    24/264 AceView cDNA sequences (see all 264):

    N44213 AA826886 BX502404 CR536529 CR604976 BM475019 BM831598 BG178804 
    AF488409 NM_078487 BM719878 BM843979 BM055160 BM701855 BQ441101 NM_004936 
    CB160611 BF000057 AI160044 AU279609 BC014469 BQ002393 AW328497 AF488410 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for CDKN2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDKN2B expression in normal human tissues (normalized intensities)      CDKN2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCTGCTT
    CDKN2B Expression
    About this image


    CDKN2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebral Cortex
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Granulosa Cells Primary Follicle
             ovary ; follicle cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See CDKN2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDKN2B

    SOURCE GeneReport for Unigene cluster: Hs.72901

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN2B (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN2B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn2b1 , 5 cyclin-dependent kinase inhibitor 2B (p15, inhibits more1, 5 84.37(n)1
    88.28(a)1
      4 (42.15 cM)5
    125791  NM_007670.41  NP_031696.11 
     893062895 
    chicken
    (Gallus gallus)
    Aves CDKN2B1 cyclin-dependent kinase inhibitor 2B (p15, inhibits more 70.4(n)
    63.79(a)
      395076  NM_204433.1  NP_989764.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    57(a)
    1 → many
    2(61354501-61364127)
    zebrafish
    (Danio rerio)
    Actinopterygii CDKN2B6
    cyclin-dependent kinase inhibitor 2B (p15, inhibit...
    44(a)
    1 → many
    1(25011641-25013679)


    ENSEMBL Gene Tree for CDKN2B (if available)
    TreeFam Gene Tree for CDKN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDKN2B gene
    CDKN2A2  CDKN2C2  CDKN2D2  
    8 SIMAP similar genes for CDKN2B using alignment to 4 protein entries:     CDN2B_HUMAN (see all proteins):
    p15    CDKN2A    CDKN2D    CDKN2C    ANKRD54    TNKS2
    ANKRD28    ANKRD65

    CDKN2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in CDKN2B are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0014894
    Lung adenocarcinoma4--see VAR_0014892 A V mis40--------
    VAR_0014884
    Lung adenocarcinoma4--see VAR_0014882 G E mis40--------
    rs1474873281,2
    --21997231(+) AATTAC/TAGAAT 2 -- ds50010--------
    rs726936181,2
    C--21997246(+) AAAAAA/GAAAAA 2 -- ds50010--------
    rs32179951,2
    C,F--21997326(-) ACTTAC/-ACTGA 2 -- ds50011Minor allele frequency- -:0.02NS 170
    rs1400639651,2
    --21997487(+) GGCGTC/TTGGGG 2 -- ds50010--------
    rs32179941,2
    C,F,H--21997633(-) CACCTA/GAGTGG 2 -- ds500120Minor allele frequency- G:0.07NS EA NA WA 2093
    rs1817364501,2
    --21997829(+) CAGGAA/CTCATG 2 -- ut310--------
    rs32179931,2
    C--21997938(-) CCACCT/CGGCAG 2 -- ut31 ese32Minor allele frequency- C:0.01NS NA 156
    rs32179921,2
    C,F,H--21997992(-) GTATTG/AAAATA 2 -- ut3130Minor allele frequency- A:0.34NS EA NA WA 3159

    HapMap Linkage Disequilibrium report for CDKN2B (22002902 - 22009362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDKN2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8426CNV Loss18304495
    nsv892748CNV Loss21882294
    nsv824877CNV Loss20364138
    nsv892746CNV Loss21882294
    nsv892745CNV Gain21882294
    nsv892747CNV Gain21882294


    Human Gene Mutation Database (HGMD): CDKN2B
    SABiosciences Cancer Mutation PCR Assays
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    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing CDKN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600431    OMIM disorders: --

    20/124 diseases for CDKN2B (see all 124):    About MalaCards
    acute lymphoblastic leukemia, childhood    laryngeal squamous cell carcinoma    thyroid lymphoma    skin melanoma
    primary malignant lymphoma    adult acute lymphocytic leukemia    diffuse astrocytoma    multiple familial trichoepithelioma
    coronary restenosis    anaplastic oligodendroglioma    pleomorphic xanthoastrocytoma    ewing's family of tumors
    oligodendroglioma    acute lymphocytic leukemia    lymphoblastic lymphoma    anaplastic astrocytoma
    myelodysplastic syndromes    mycosis fungoides    actinic keratosis    refractory anemia

    1 disease from the University of Copenhagen DISEASES database for CDKN2B:
    Cancer

    CDKN2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/86 Novoseek inferred disease relationships for CDKN2B gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 70.7 14 16140969 (1), 17513607 (1), 9058294 (1), 9327828 (1) (see all 13)
    tumors 68.2 350 7563186 (5), 11764089 (4), 8689637 (4), 9816033 (4) (see all 99)
    t-all 67.9 39 9041181 (5), 9399648 (4), 10778944 (4), 8630377 (2) (see all 15)
    myelodysplastic syndromes 66 21 17095538 (2), 9269757 (2), 9531610 (2), 11167795 (2) (see all 13)
    multiple tumors 64.3 3 8957063 (1), 9827724 (1), 9698532 (1)
    allelic imbalance 62.4 7 18564286 (1), 18712977 (1), 18331779 (1)
    lymphoblastic leukemia acute 61.2 29 7780130 (2), 7994022 (2), 8683987 (1), 8816064 (1) (see all 22)
    allelic loss 61.1 6 7780130 (1), 9501299 (1), 11874489 (1), 8855819 (1)
    primary tumor 60.1 12 7882348 (1), 8760309 (1), 9698478 (1), 8689636 (1) (see all 9)
    lymphoblastic leukemia acute childhood 58.2 14 9399648 (2), 9737691 (2), 8816064 (1), 12661005 (1) (see all 8)

    Genetic Association Database (GAD): CDKN2B
    Human Genome Epidemiology (HuGE) Navigator: CDKN2B (146 documents)

    Export disorders for CDKN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDKN2B gene, integrated from 9 sources (see all 796):
    (articles sorted by number of sources associating them with CDKN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PubMed id 8078588)1, 2, 3, 9 Hannon G.J. and Beach D. (1994)
    2. Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)1, 4, 9 Soto Martinez J.L....Lopez-Nevot M.A. (2005)
    3. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (PubMed id 7882351)1, 2, 9 Okamoto A.... Harris C.C. (1995)
    4. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. (PubMed id 19141585)1, 4, 9 Agarwal S.K....Marx S.J. (2009)
    5. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. (PubMed id 17008550)1, 4, 9 Healy J....Sinnett D. (2007)
    6. MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. (PubMed id 19272367)1, 4, 9 Yang X.C....Wang X.F. (2009)
    7. Genetic variants in the cell cycle control pathways c ontribute to early onset colorectal cancer in Lynch syndrome. (PubMed id 19690970)1, 4, 9 Chen J....Frazier M.L. (2009)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (2008)
    10. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PubMed id 17928989)1, 4, 9 Horikoshi M....Kadowaki T. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1030 HGNC: 1788 AceView: CDKN2AandCDKN2B Ensembl:ENSG00000147883 euGenes: HUgn1030
    ECgene: CDKN2B Kegg: 1030 H-InvDB: CDKN2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDKN2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN2B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn2b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDKN2B gene:
    Search GeneIP for patents involving CDKN2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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