Set Analyses:
Advanced Search

Advanced Search

Search By
Section (entire)

or upload a file of gene symbols

Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21


protein-coding   GIFtS: 68
GCID: GC09M021992

Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)1 2     CDK Inhibitory Protein2
MTS22 3 5     CDK4B Inhibitor2
Multiple Tumor Suppressor 22 3     Cyclin-Dependent Kinase 4 Inhibitor B2
MTS-22 3     Cyclin-Dependent Kinases 4 And 6 Binding Protein2
p14-INK4b2 3     p14_INK4B2
p15-INK4b2 3     P14_CDK Inhibitor2
INK4B2 5     P15 CDK Inhibitor2
P152 5     p15INK4b2
CDK4I2     p15_INK4B2
TP152     p15INK4B3

External Ids:    HGNC: 17881   Entrez Gene: 10302   Ensembl: ENSG000001478837   OMIM: 6004315   UniProtKB: P427723   

Export aliases for CDKN2B gene to outside databases

Previous GC identifers: GC09M022331 GC09M022204 GC09M021994

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN2B Gene:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in
a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4
or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth
regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically
induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively
spliced transcript variants of this gene, which encode distinct proteins, have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDKN2B Gene: 
CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) is a protein-coding gene. Diseases associated with CDKN2B include acute lymphoblastic leukemia, childhood, and laryngeal squamous cell carcinoma, and among its related super-pathways are G1-S Phase Transition and Mitotic G1-G1/S phases. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
cycle arrest

Gene Wiki entry for CDKN2B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKN2B gene promoter:
         PPAR-gamma1   Sp1   p53   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN2B promoter sequence
   Search SABiosciences Chromatin IP Primers for CDKN2B

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21

CDKN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021992:  view genomic region     (about GC identifiers)

22,002,902 bp from pter      End:
22,009,362 bp from pter
6,461 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4 inhibitor B  
Size: 138 amino acids; 14722 Da
Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6
Subcellular location: Cytoplasm. Note=Also found in the nucleus
Secondary accessions: O15125 Q6FI09
Alternative splicing: 2 isoforms:  P42772-1   P42772-2   

Explore the universe of human proteins at neXtProt for CDKN2B: NX_P42772

Explore proteomics data for CDKN2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42772

  • CDKN2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDKN2B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004927.2  NP_511042.1  

    ENSEMBL proteins: 
     ENSP00000276925   ENSP00000369487   ENSP00000445136  
    Reactome Protein details: P42772
    Human Recombinant Protein Products for CDKN2B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CDKN2B
    OriGene Protein Over-expression Lysate for CDKN2B
    OriGene MassSpec for CDKN2B 
    OriGene Custom Protein Services for CDKN2B
    GenScript Custom Purified and Recombinant Proteins Services for CDKN2B
    Novus Biologicals CDKN2B Protein
    Novus Biologicals CDKN2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDKN2B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18564286
    GO:0005737cytoplasm IDA16943770
    GO:0005829cytosol TAS--

    CDKN2B for ontologies           About GeneDecksing

    CDKN2B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN2B
    R&D Systems Antibodies for CDKN2B (p15INK4b/CDKN2B)
    OriGene Antibodies for CDKN2B
    OriGene Custom Antibody Services for CDKN2B
    GenScript Custom Superior Antibodies Services for CDKN2B
    Novus Biologicals CDKN2B Antibodies
    Abcam antibodies for CDKN2B
    Cloud-Clone Corp. Antibodies for CDKN2B 
    ThermoFisher Antibodies for CDKN2B
    LSBio Antibodies in human, mouse, rat for CDKN2B 

    Assay Products for CDKN2B: 
    EMD Millipore Kits and Assays for the Analysis of CDKN2B
    OriGene Custom Assay Services for CDKN2B
    Browse R&D Systems for biochemical assays
    GenScript CDKN2B-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDKN2B 
    Cloud-Clone Corp. CLIAs for CDKN2B

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P42772

    ProtoNet protein and cluster: P42772

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
    Similarity: Contains 4 ANK repeats

    CDKN2B for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN2B_HUMAN, P42772
    Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
    cycle arrest

         Genatlas biochemistry entry for CDKN2B:
    cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1
    checkpoint,tightly linked and highly homolog to CDKN2A

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity NAS9230210
    GO:0005515protein binding IPI16169070
    GO:0019901protein kinase binding IPI8078588
    CDKN2B for ontologies           About GeneDecksing

         4 GenomeRNAi human phenotypes for CDKN2B:
     Decreased cilium length  Decreased cilium length after   Decreased telomerase activity  Increased cell number in G2M,  

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdkn2b):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system 

    CDKN2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDKN2B: Cdkn2btm1Bbd Cdkn2btm1Brn Cdkn2a/Cdkn2bCdkn2a/tm1Brn Cdkn2a/Cdkn2bCdkn2a/tm2Brn Cdkn2btm2Brn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDKN2B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDKN2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN2B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN2B 

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN2B
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN2B (see all 25):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDKN2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN2B

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for CDKN2B
    Sirion Biotech Customized adenovirus for overexpression of CDKN2B

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDKN2B (see all 13)
    OriGene ORF clones in mouse, rat for CDKN2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2B (NM_004936)
    Sino Biological Human cDNA Clone for CDKN2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
    Sirion Biotech Customized lentivirus for stable overexpression of CDKN2B 
                         Customized lentivirus expression plasmids for stable overexpression of CDKN2B 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for CDKN2B
    LifeMap BioReagents: cell line associated with CDKN2B: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDKN2B About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    3Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CDKN2B
        Development Role of Activin A in cell differentiation and proliferation
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN2B
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Pancreatic Adenocarcinoma

    3 GeneGo (Thomson Reuters) Pathways for CDKN2B
        Cell cycle Regulation of G1/S transition (part 1)
    Development Role of Activin A in cell differentiation and proliferation
    Development TGF-beta receptor signaling

    5 BioSystems Pathways for CDKN2B
        G1 to S cell cycle control
    Signaling Pathways in Glioblastoma
    Integrated Pancreatic Cancer Pathway
    Regulation of nuclear SMAD2/3 signaling
    Validated targets of C-MYC transcriptional repression

    5/11        Reactome Pathways for CDKN2B (see all 11)
        G1 Phase
    Generic Transcription Pathway
    Mitotic G1-G1/S phases
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Cell Cycle

    5/6         Kegg Pathways  (Kegg details for CDKN2B) (see all 6):
        Cell cycle
    TGF-beta signaling pathway
    HTLV-I infection
    Pathways in cancer
    Viral carcinogenesis

    CDKN2B for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for CDKN2B (P427721, 2, 3 ENSP000002769254) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-711280,EBI-295644 MINT-8251348 I2D: score=6 STRING: ENSP00000257904
    CDK8P493363, ENSP000003709384I2D: score=1 STRING: ENSP00000370938
    CDK6Q005341, ENSP000002657344EBI-711280,EBI-295663 STRING: ENSP00000265734
    ZBTB17Q131053, ENSP000003648954I2D: score=1 STRING: ENSP00000364895
    MAGEA11P433643, ENSP000003473584I2D: score=4 STRING: ENSP00000347358
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA8078588
    GO:0000086G2/M transition of mitotic cell cycle IMP17553787
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    CDKN2B for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDKN2B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDKN2B (CDN2B)

    10/19 Novoseek inferred chemical compound relationships for CDKN2B gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methylthioadenosine 75.7 10 18163473 (1), 12661005 (1), 16618910 (1), 19272367 (1) (see all 7)
    5-aza-2'deoxycytidine 70.4 28 12351408 (3), 18718068 (3), 19881540 (2), 15015578 (2) (see all 12)
    sodium bisulfite 64.2 3 17369979 (1), 9808523 (1), 10637497 (1)
    tgf beta1 18.1 5 16871886 (2), 14693046 (1), 11082295 (1)
    5-methylcytosine 16.1 1 9808523 (1)
    o6-methylguanine 15.9 2 15197802 (1)
    retinoic acid 7.43 3 10896783 (1), 15839997 (1)
    pd 98,059 7.28 2 16322252 (1), 17513607 (1)
    arsenite 4.79 3 11877046 (3)
    azathioprine 2.25 1 15015578 (1)

    Search CenterWatch for drugs/clinical trials and news about CDKN2B / CDN2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDKN2B gene (2 alternative transcripts): 
    NM_004936.3  NM_078487.2  

    Unigene Cluster for CDKN2B:

    Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
    Hs.72901  [show with all ESTs]
    Unigene Representative Sequence: NM_078487
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276925(uc003zpn.3 uc003zpo.3) ENST00000579591 ENST00000380142

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN2B
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN2B (see all 25):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDKN2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN2B
    OriGene clones in human, mouse for CDKN2B (see all 13)
    OriGene ORF clones in mouse, rat for CDKN2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2B (NM_004936)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
    Sirion Biotech Customized lentivirus for stable overexpression of CDKN2B 
                         Customized lentivirus expression plasmids for stable overexpression of CDKN2B 
    OriGene qPCR primer pairs and template standards for CDKN2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CDKN2B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDKN2B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B

    Additional mRNA sequence: 

    AF004819.1 AF488409.1 AF488410.1 AF488411.1 AF488731.1 BC014469.1 BC018984.2 CR536529.1 
    L36844.1 U17075.1 

    5 DOTS entries:

    DT.40207564  DT.91660559  DT.121147154  DT.75102662  DT.95150832 

    24/264 AceView cDNA sequences (see all 264):

    N44213 AA826886 BX502404 CR536529 CR604976 BM475019 BM831598 BG178804 
    AF488409 NM_078487 BM719878 BM843979 BM055160 BM701855 BQ441101 NM_004936 
    CB160611 BF000057 AI160044 AU279609 BC014469 BQ002393 AW328497 AF488410 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               

    ECgene alternative splicing isoforms for CDKN2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDKN2B expression in normal human tissues (normalized intensities)      CDKN2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CDKN2B Expression
    About this image

    CDKN2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebral Cortex
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Granulosa Cells Primary Follicle
             ovary ; follicle cells   
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See CDKN2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDKN2B

    SOURCE GeneReport for Unigene cluster: Hs.72901

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN2B (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

    OriGene qPCR primer pairs and template standards for CDKN2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CDKN2B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDKN2B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN2B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Cdkn2b1 , 5 cyclin-dependent kinase inhibitor 2B (p15, inhibits more1, 5 84.37(n)1
      4 (42.15 cM)5
    125791  NM_007670.41  NP_031696.11 
    (Gallus gallus)
    Aves CDKN2B1 cyclin-dependent kinase inhibitor 2B (p15, inhibits more 70.4(n)
      395076  NM_204433.1  NP_989764.1 
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    1 → many
    (Danio rerio)
    Actinopterygii CDKN2B6
    cyclin-dependent kinase inhibitor 2B (p15, inhibit...
    1 → many

    ENSEMBL Gene Tree for CDKN2B (if available)
    TreeFam Gene Tree for CDKN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section
    Paralogs for CDKN2B gene
    CDKN2A2  CDKN2C2  CDKN2D2  
    8 SIMAP similar genes for CDKN2B using alignment to 4 protein entries:     CDN2B_HUMAN (see all proteins):
    p15    CDKN2A    CDKN2D    CDKN2C    ANKRD54    TNKS2
    ANKRD28    ANKRD65

    CDKN2B for paralogs           About GeneDecksing

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in CDKN2B are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 9 posSequence#AA
    Lung adenocarcinoma4--see VAR_0014892 A V mis40--------
    Lung adenocarcinoma4--see VAR_0014882 G E mis40--------
    --21997231(+) AATTAC/TAGAAT 2 -- ds50010--------
    C--21997246(+) AAAAAA/GAAAAA 2 -- ds50010--------
    C,F--21997326(-) ACTTAC/-ACTGA 2 -- ds50011Minor allele frequency- -:0.02NS 170
    --21997487(+) GGCGTC/TTGGGG 2 -- ds50010--------
    C,F,H--21997633(-) CACCTA/GAGTGG 2 -- ds500120Minor allele frequency- G:0.07NS EA NA WA 2093
    --21997829(+) CAGGAA/CTCATG 2 -- ut310--------
    C--21997938(-) CCACCT/CGGCAG 2 -- ut31 ese32Minor allele frequency- C:0.01NS NA 156
    C,F,H--21997992(-) GTATTG/AAAATA 2 -- ut3130Minor allele frequency- A:0.34NS EA NA WA 3159

    HapMap Linkage Disequilibrium report for CDKN2B (22002902 - 22009362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDKN2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8426CNV Loss18304495
    nsv892748CNV Loss21882294
    nsv824877CNV Loss20364138
    nsv892746CNV Loss21882294
    nsv892745CNV Gain21882294
    nsv892747CNV Gain21882294

    Human Gene Mutation Database (HGMD): CDKN2B
    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing CDKN2B:
    Oncogenes & Tumor Suppressor Genes 384HC
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing CDKN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600431    OMIM disorders: --

    20/124 diseases for CDKN2B (see all 124):    About MalaCards
    acute lymphoblastic leukemia, childhood    laryngeal squamous cell carcinoma    thyroid lymphoma    skin melanoma
    primary malignant lymphoma    adult acute lymphocytic leukemia    diffuse astrocytoma    multiple familial trichoepithelioma
    coronary restenosis    anaplastic oligodendroglioma    pleomorphic xanthoastrocytoma    ewing's family of tumors
    oligodendroglioma    acute lymphocytic leukemia    lymphoblastic lymphoma    anaplastic astrocytoma
    myelodysplastic syndromes    mycosis fungoides    actinic keratosis    refractory anemia

    1 disease from the University of Copenhagen DISEASES database for CDKN2B:

    CDKN2B for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/86 Novoseek inferred disease relationships for CDKN2B gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 70.7 14 16140969 (1), 17513607 (1), 9058294 (1), 9327828 (1) (see all 13)
    tumors 68.2 350 7563186 (5), 11764089 (4), 8689637 (4), 9816033 (4) (see all 99)
    t-all 67.9 39 9041181 (5), 9399648 (4), 10778944 (4), 8630377 (2) (see all 15)
    myelodysplastic syndromes 66 21 17095538 (2), 9269757 (2), 9531610 (2), 11167795 (2) (see all 13)
    multiple tumors 64.3 3 8957063 (1), 9827724 (1), 9698532 (1)
    allelic imbalance 62.4 7 18564286 (1), 18712977 (1), 18331779 (1)
    lymphoblastic leukemia acute 61.2 29 7780130 (2), 7994022 (2), 8683987 (1), 8816064 (1) (see all 22)
    allelic loss 61.1 6 7780130 (1), 9501299 (1), 11874489 (1), 8855819 (1)
    primary tumor 60.1 12 7882348 (1), 8760309 (1), 9698478 (1), 8689636 (1) (see all 9)
    lymphoblastic leukemia acute childhood 58.2 14 9399648 (2), 9737691 (2), 8816064 (1), 12661005 (1) (see all 8)

    Genetic Association Database (GAD): CDKN2B
    Human Genome Epidemiology (HuGE) Navigator: CDKN2B (146 documents)

    Export disorders for CDKN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDKN2B gene, integrated from 9 sources (see all 796) (see top 10):
    (articles sorted by number of sources associating them with CDKN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PubMed id 8078588)1, 2, 3, 9 Hannon G.J. and Beach D. (1994)
    2. Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)1, 4, 9 Soto Martinez J.L....Lopez-Nevot M.A. (2005)
    3. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (PubMed id 7882351)1, 2, 9 Okamoto A.... Harris C.C. (1995)
    4. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. (PubMed id 19141585)1, 4, 9 Agarwal S.K....Marx S.J. (2009)
    5. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. (PubMed id 17008550)1, 4, 9 Healy J....Sinnett D. (2007)
    6. MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. (PubMed id 19272367)1, 4, 9 Yang X.C....Wang X.F. (2009)
    7. Genetic variants in the cell cycle control pathways c ontribute to early onset colorectal cancer in Lynch syndrome. (PubMed id 19690970)1, 4, 9 Chen J....Frazier M.L. (2009)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (2008)
    10. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PubMed id 17928989)1, 4, 9 Horikoshi M....Kadowaki T. (2007)
    11. Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma. (PubMed id 17909067)1, 4, 9 Ruiz-Llorente S....Robledo M. (2007)
    12. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PubMed id 17409409)1, 4, 9 Gayther S.A....Pharoah P.D. (2007)
    13. Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. (PubMed id 10892805)1, 2, 9 Yuan C.... Tsai M.D. (2000)
    14. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)1, 2, 9 Guan K.-L.... Xiong Y. (1994)
    15. A genome-wide association study in the Japanese popula tion confirms 9p21 and 14q23 as susceptibility loci for primary open angle glauc oma. (PubMed id 22419738)1, 4 Osman W....Nakamura Y. (2012)
    16. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    17. Glycemia determines the effect of type 2 diabetes ris k genes on insulin secretion. (PubMed id 20802253)1, 4 Heni M....HAoring H.U. (2010)
    18. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (2010)
    19. Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort. (PubMed id 20616309)1, 4 Pechlivanis S....Moebus S. (2010)
    20. Polygenic risk variants for type 2 diabetes susceptib ility modify age at diagnosis in monogenic HNF1A diabetes. (PubMed id 19794065)1, 4 Lango Allen H....Weedon M.N. (2010)
    21. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and H HEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (2010)
    22. Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. (PubMed id 20386740)1, 4 Cunnington M.S....Keavney B. (2010)
    23. Improvements in glucose homeostasis in response to re gular exercise are influenced by the PPARG Pro12Ala variant: results from the H ERITAGE Family Study. (PubMed id 20043145)1, 4 Ruchat S.M....PAcrusse L. (2010)
    24. Evidence of Interaction between Type 2 Diabetes Susce ptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-Re lated Phenotypes. (PubMed id 20215779)1, 4 Ruchat S.M....PAcrusse L. (2010)
    25. A genome-wide association study of nasopharyngeal car cinoma identifies three new susceptibility loci. (PubMed id 20512145)1, 4 Bei J.X....Zeng Y.X. (2010)
    26. Genome-wide association study of intracranial aneurys m identifies three new risk loci. (PubMed id 20364137)1, 4 Yasuno K....GA1nel M. (2010)
    27. Interaction between 5 genetic variants and allergy in glioma risk. (PubMed id 20462933)1, 4 Schoemaker M.J....Swerdlow A.J. (2010)
    28. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    29. Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (2010)
    30. Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. (PubMed id 19933996)1, 4 Zhao J....Grant S.F. (2010)
    31. Detecting rare variants for complex traits using fami ly and unrelated data. (PubMed id 19847924)1, 4 Zhu X....Elston R.C. (2010)
    32. Genetic risk profiles identify different molecular et iologies for glioma. (PubMed id 20847058)1, 4 Simon M....Sanson M. (2010)
    33. Implication of genetic variants near SLC30A8, HHEX, C DKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Ch inese population. (PubMed id 20509872)1, 4 Han X....Ji L. (2010)
    34. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collabora tive study. (PubMed id 20712903)1, 4 Morgan A.R....Mitchell E.A. (2010)
    35. Association study of genetic variants in eight genes/ loci with type 2 diabetes in a Han Chinese population. (PubMed id 20550665)1, 4 Lin Y....Yang Z. (2010)
    36. Combining genetic markers and clinical risk factors i mproves the risk assessment of impaired glucose metabolism. (PubMed id 20384434)1, 4 Ruchat S.M....PAcrusse L. (2010)
    37. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. (PubMed id 20075150)1, 4 Talmud P.J....Humphries S.E. (2010)
    38. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PubMed id 20161779)1, 4 Wen J....Hu R. (2010)
    39. Impact of single nucleotide polymorphisms and of clin ical risk factors on newa89onset diabetes mellitus in HIVa89infected individuals. (PubMed id 20879858)1, 4 Rotger M....Tarr P.E. (2010)
    40. Combined risk allele score of eight type 2 diabetes g enes is associated with reduced first-phase glucose-stimulated insulin secretio n during hyperglycemic clamps. (PubMed id 19808892)1, 4 't Hart L.M....Fritsche A. (2010)
    41. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    42. A genome-wide association study of optic disc paramet ers. (PubMed id 20548946)1, 4 Ramdas W.D....van Duijn C.M. (2010)
    43. A multilocus genetic risk score for coronary heart di sease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (2010)
    44. Polymorphisms identified through genome-wide associat ion studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. (PubMed id 19892838)1, 4 Tan J.T....Tai E.S. (2010)
    45. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    46. Additive effect of multiple genetic variants on the r isk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (2010)
    47. Genetic susceptibility to type 2 diabetes is associat ed with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (2010)
    48. The susceptibility CDKN2 locus may have a role on pro gnosis of melanoma patients. (PubMed id 20231302)1, 4 Casula M....Palmieri G. (2010)
    49. Confirmation of an association of single-nucleotide p olymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. (PubMed id 20395613)1, 4 Hashikata H....Koizumi A. (2010)
    50. Association of single nucleotide polymorphisms on chr omosome 9p21.3 with platelet reactivity: a potential mechanism for increased va scular disease. (PubMed id 20858905)1, 4 Musunuru K....Mitchell B.D. (2010)
    51. A composite scoring of genotypes discriminates corona ry heart disease risk beyond conventional risk factors in the Boston Puerto Ric an Health Study. (PubMed id 19501493)1, 4 Junyent M....Ordovas J.M. (2009)
    52. Variants in the CDKN2B and RTEL1 regions are associat ed with high-grade glioma susceptibility. (PubMed id 19578366)1, 4 Wrensch M....Wiencke J.K. (2009)
    53. Detection of gene copy number aberrations in mantle c ell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4 Jardin F....Tilly H. (2009)
    54. Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. (PubMed id 19592620)1, 4 Zhao J....Grant S.F. (2009)
    55. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. (PubMed id 19139842)1, 4 Lin X....Mooser V. (2009)
    56. Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. (PubMed id 19247372)1, 4 Miyake K....Kasuga M. (2009)
    57. Genome-wide association study identifies five suscept ibility loci for glioma. (PubMed id 19578367)1, 4 Shete S....Houlston R.S. (2009)
    58. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. (PubMed id 19214202)1, 4 Schaefer A.S....Schreiber S. (2009)
    59. Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. (PubMed id 19324937)1, 4 Brito E.C....Franks P.W. (2009)
    60. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese populatio n. (PubMed id 19862325)1, 4 Hu C....Jia W. (2009)
    61. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    62. Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study. (PubMed id 19741166)1, 4 Kelliny C....Langenberg C. (2009)
    63. Association of common type 2 diabetes risk gene varia nts and posttransplantation diabetes mellitus in renal allograft recipients in Korea. (PubMed id 19741467)1, 4 Kang E.S....Kim Y.S. (2009)
    64. Underlying genetic models of inheritance in establish ed type 2 diabetes associations. (PubMed id 19602701)1, 4 Salanti G....Ioannidis J.P. (2009)
    65. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. (PubMed id 19225753)1, 4 Pulizzi N....Eriksson J.G. (2009)
    66. New common variants affecting susceptibility to basal cell carcinoma. (PubMed id 19578363)1, 4 Stacey S.N....Stefansson K. (2009)
    67. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. (PubMed id 19056611)1, 4 Timpson N.J....McCarthy M.I. (2009)
    68. Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism. (PubMed id 19258437)1, 4 van Hoek M....Roseboom T.J. (2009)
    69. Association of 18 confirmed susceptibility loci for t ype 2 diabetes with indices of insulin release, proinsulin conversion, and insu lin sensitivity in 5,327 nondiabetic Finnish men. (PubMed id 19502414)1, 4 StancA!kovA! A....Laakso M. (2009)
    70. ETV6-RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis. (PubMed id 19665068)1, 4 Emerenciano M....Pombo-de-Oliveira M.S. (2009)
    71. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)1, 4  ....Altshuler D. (2009)
    72. Type 2 diabetes risk alleles are associated with reduced size at birth. (PubMed id 19228808)1, 4 Freathy R.M....Hattersley A.T. (2009)
    73. Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. (PubMed id 19279076)1, 4 Qi L....Hu F.B. (2009)
    74. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. (PubMed id 19166692)1, 4 van der Net J.B....Steyerberg E.W. (2009)
    75. The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. (PubMed id 19293724)1, 4 Wahlstrand B....Melander O. (2009)
    76. Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas. (PubMed id 19383911)1, 4 Kuo K.T....Wang T.L. (2009)
    77. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. (PubMed id 19380854)1, 4 Cornelis M.C....Hu F.B. (2009)
    78. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4 Goode E.L....Sellers T.A. (2009)
    79. Use of multiple metabolic and genetic markers to impr ove the prediction of type 2 diabetes: the EPIC-Potsdam Study. (PubMed id 19720844)1, 4 Schulze M.B....Joost H.G. (2009)
    80. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)
    81. Frequent genomic abnormalities in acute myeloid leuke mia/myelodysplastic syndrome with normal karyotype. (PubMed id 19144660)1, 4 Akagi T....Koeffler H.P. (2009)
    82. The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity. (PubMed id 19258404)1, 4 Haupt A....HAoring H.U. (2009)
    83. Confirmation of multiple risk Loci and genetic impact s by a genome-wide association study of type 2 diabetes in the Japanese populat ion. (PubMed id 19401414)1, 4 Takeuchi F....Kato N. (2009)
    84. Genetic variants on chromosome 9p21 and ischemic stro ke in Chinese. (PubMed id 19559344)1, 4 Hu W.L....Wang X.F. (2009)
    85. Common type 2 diabetes risk gene variants associate with gestational diabetes. (PubMed id 18984664)1, 4 Lauenborg J....Hansen T. (2009)
    86. Explorative study to identify novel candidate genes r elated to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (2009)
    87. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PubMed id 18372903)1, 4 Zeggini E....Altshuler D. (2008)
    88. Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). (PubMed id 18437351)1, 4 Hertel J.K....Njolstad P.R. (2008)
    89. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. (PubMed id 19002430)1, 4 Cho Y.M....Jang H.C. (2008)
    90. Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study. (PubMed id 18925945)1, 4 Dehghan A....Witteman J.C. (2008)
    91. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PubMed id 18599554)1, 4 van der Net J.B....Sijbrands E.J. (2008)
    92. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4 Driver K.E....Dunning A.M. (2008)
    93. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. (PubMed id 18991055)1, 4 Lee Y.H....Lee H.C. (2008)
    94. Association analysis of type 2 diabetes Loci in type 1 diabetes. (PubMed id 18426861)1, 4 Qu H.Q....Polychronakos C. (2008)
    95. Clinical risk factors, DNA variants, and the development of type 2 diabetes. (PubMed id 19020324)1, 4 Lyssenko V....Groop L. (2008)
    96. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. (PubMed id 18591388)1, 4 Lango H....Weedon M.N. (2008)
    97. Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. (PubMed id 18461161)1, 4 Cauchi S....Froguel P. (2008)
    98. Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 Genes Confer Risk of Type 2 Diabetes Independently of BMI in the German KORA Studies. (PubMed id 18597214)1, 4 Herder C....Illig T. (2008)
    99. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. (PubMed id 18469204)1, 4 Ng M.C....Cho N.H. (2008)
    100. Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids. (PubMed id 18368387)1, 4 Duesing K....Gibson F. (2008)
    101. Susceptibility loci for intracranial aneurysm in European and Japanese populations. (PubMed id 18997786)1, 4 Bilguvar K....GA1nel M. (2008)
    102. Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. (PubMed id 19033397)1, 4 Tabara Y....Makino H. (2008)
    103. Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. (PubMed id 18618095)1, 4 Groenewoud M.J....van Haeften T.W. (2008)
    104. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. (PubMed id 18162508)1, 4 Omori S....Maeda S. (2008)
    106. Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population. (PubMed id 18516622)1, 4 Bronstein M....Darvasi A. (2008)
    107. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. (PubMed id 18633108)1, 4 Wu Y....Lin X. (2008)
    108. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. (PubMed id 18477659)1, 4 Horikawa Y....Kasuga M. (2008)
    109. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (2008)
    110. Genotype score in addition to common risk factors for prediction of type 2 diabetes. (PubMed id 19020323)1, 4 Meigs J.B....Cupples L.A. (2008)
    111. Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. (PubMed id 19082521)1, 4 Ruchat S.M....PAcrusse L. (2008)
    112. Association Analysis of Variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761 and CDKN2B with Type 2 Diabetes and Related Quantitative Traits in Pima Indians. (PubMed id 19008344)1, 4 Rong R....Baier L.J. (2008)
    113. Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles. (PubMed id 18719881)1, 4 Pascoe L....Walker M. (2008)
    114. Genome-wide association study of susceptibility alleles for coronary artery disease. (PubMed id 18489844)1, 4 Marian A.J. (2008)
    115. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. (PubMed id 18210030)1, 4 Cauchi S....Froguel P. (2008)
    116. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PubMed id 17463248)1, 4 Scott L.J....Boehnke M. (2007)
    117. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. (PubMed id 17463246)1, 4  ....Purcell S. (2007)
    118. A common variant of the p16(INK4a) genetic region is associated with physical function in older people. (PubMed id 17459456)1, 4 Melzer D....Pharoah P.D. (2007)
    119. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. (PubMed id 17827400)1, 4 Grarup N....Pedersen O. (2007)
    120. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4  . (2007)
    121. A common allele on chromosome 9 associated with coronary heart disease. (PubMed id 17478681)1, 4 McPherson R....Cohen J.C. (2007)
    122. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. (PubMed id 17463249)1, 4 Zeggini E....Hattersley A.T. (2007)
    123. A common variant on chromosome 9p21 affects the risk of myocardial infarction. (PubMed id 17478679)1, 4 Helgadottir A....Stefansson K. (2007)
    124. Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. (PubMed id 17804762)1, 4 Pascoe L.... . (2007)
    125. Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694)1, 4 Starinsky S....Friedman E. (2005)
    126. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    127. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    128. Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. (PubMed id 12556369)1, 4 Hearle N.... Houlston R.S. (2003)
    129. A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. (PubMed id 11668523)1, 4 Kumar R....Hemminki K. (2001)
    130. Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor. (PubMed id 9230210)1, 2 Tsubari M.... Laiho M. (1997)
    131. A cell cycle regulator potentially involved in genesis of many tumor types. (PubMed id 8153634)1, 2 Kamb A....Skolnick M.H. (1994)
    132. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. (PubMed id 19164764)1, 9 Basu S....Dong F. (2009)
    133. Signatures of polycomb repression and reduced H3K4 tr imethylation are associated with p15INK4b DNA methylation in AML. (PubMed id 20190193)1, 9 Paul T.A....Wolff L. (2010)
    134. Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer. (PubMed id 16872319)1, 9 Ishiguro A....Munakata A. (2006)
    135. Genomic structure, expression and mutational analysis of the P15 (MTS2) gene. (PubMed id 7675459)1, 9 Stone S....Kamb A. (1995)
    136. Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis. (PubMed id 15112341)1, 9 Qin Y....Sun Z.F. (2004)
    137. Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. (PubMed id 16943770)1, 9 Chen Z....Pflugfelder S.C. (2006)
    138. p15 mRNA expression detected by real-time quantitative reverse transcriptase-polymerase chain reaction correlates with the methylation density of the gene in adult acute leukemia. (PubMed id 15755508)1, 9 Matsuno N....Asou N. (2005)
    139. Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. (PubMed id 9111314)1, 9 Sandhu C....Stampfer M.R. (1997)
    140. Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer. (PubMed id 16000597)1, 9 Liu Z....Wei Q. (2005)
    141. DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance. (PubMed id 19727727)1, 9 Stanganelli C....Slavutsky I. (2010)
    142. Immunohistochemical determination of the P15 protein expression in cutaneous squamous cell carcinoma. (PubMed id 18564286)1, 9 Moad A.I....Mabruk M.J. (2009)
    143. p15 promoter methylation - A novel prognostic marker in glioblastoma patients. (PubMed id 19424593)1, 9 Wemmert S....Urbschat S. (2009)
    144. Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis. (PubMed id 18331779)1, 9 Kanellou P....Spandidos D.A. (2008)
    145. Hypermethylation of the p15INK4B gene promoter in B-chronic lymphocytic leukemia. (PubMed id 17546638)1, 9 Papageorgiou S.G....Economopoulos T. (2007)
    146. Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome. (PubMed id 11874489)1, 9 Scarisbrick J.J....Whittaker S.J. (2002)
    147. Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. (PubMed id 10574984)1, 9 Rich J.N....Wang X.F. (1999)
    148. The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. (PubMed id 9042862)1, 9 Reynisdottir I. and Massague J. (1997)
    149. Homozygous deletion of CDKN2A (p16, p14) and CDKN2B ( p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study . (PubMed id 19837270)1, 9 Kim M....Lee D.S. (2009)
    150. Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours. (PubMed id 17803708)1, 9 Lindberg D....Westin G. (2008)
    151. Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders. (PubMed id 15813917)1, 9 Kawamata N....Oshimi K. (2005)
    152. [Synergistic effects of VPA and As2O3 on Molt-4 cells in vitro and its possible mechanisms] (PubMed id 19099629)1, 9 Ye B.G....Lin C.M. (2008)
    153. Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors. (PubMed id 18551412)1, 9 Almeida L.O....Casartelli C. (2008)
    154. Aberrant methylation of multiple genes in gastric carcinomas. (PubMed id 17652530)1, 9 Zhao Y.F....Jie Zheng . (2007)
    155. Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma. (PubMed id 15937071)1, 9 Laud K....Bressac-de Paillerets B. (2006)
    156. Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2B. (PubMed id 15819981)1, 9 Soto J.L....Lopez-Nevot M.A. (2005)
    157. ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. (PubMed id 17513607)1, 9 Koyama M....Sakai T. (2007)
    158. Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression. (PubMed id 16799475)1, 9 Zhang Z....Liu J. (2006)
    159. Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma. (PubMed id 16618910)1, 9 Worsham M.J....Benninger M.S. (2006)
    160. Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. (PubMed id 15475071)1, 9 Scott S.A....DeCoteau J.F. (2004)
    161. p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. (PubMed id 14519636)1, 9 Perrone F....Pilotti S. (2003)
    162. Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression. (PubMed id 11859969)1, 9 Simon M....Schramm J. (2001)
    163. Deletion of p16 and p15 genes in brain tumors. (PubMed id 7987828)1, 9 Jen J.... Vogelstein B. (1994)
    164. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    165. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    166. Genome-wide association study of coronary and aortic c alcification implicates risk loci for coronary artery disease and myocardial inf arction. (PubMed id 23561647)1 van Setten Bakker P.I. (2013)
    167. Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma. (PubMed id 23275143)1 Krajnovic M....Krtolica K. (2013)
    168. Loss of CDKN2B promotes p53-dependent smooth muscle ce ll apoptosis and aneurysm formation. (PubMed id 23162013)1 Leeper N.J....Quertermous T. (2013)
    169. JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia. (PubMed id 22086844)1 Nakamura S....Ohnishi K. (2013)
    170. A genome-wide association study identifies GRK5 and RA SGRP1 as type 2 diabetes loci in Chinese Hans. (PubMed id 22961080)1 Li H....Lin X. (2013)
    171. Resequencing and clinical associations of the 9p21.3 r egion: a comprehensive investigation in the Framingham heart study. (PubMed id 23315372)1 Johnson A.D....O'Donnell C.J. (2013)
    172. Identification of human protein interaction domains us ing an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)1 Waaijers S....Boxem M. (2013)
    173. Common genetic variants in the 9p21 region and their a ssociations with multiple tumours. (PubMed id 23361049)1 Gu F....Yang X.R. (2013)
    174. Elite Model for the Generation of Induced Pluripotent Cancer Cells (iPCs). (PubMed id 23418593)1 Lai J.... Wang X. (2013)
    175. Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian po pulation. (PubMed id 23504555)1 do Nascimento Borges B....Harada M.L. (2013)
    176. Interferon-g activates expression of p15 and p16 regar dless of 9p21.3 coronary artery disease risk genotype. (PubMed id 23199516)1 Almontashiri N.A....Stewart A.F. (2013)
    177. Association between chromosome 9p21 variants and the a nkle-brachial index identified by a meta-analysis of 21 genome-wide association studies. (PubMed id 22199011)1 Murabito J.M....Kronenberg F. (2012)
    178. 1000 Genomes-based imputation identifies novel and ref ined associations for the Wellcome Trust Case Control Consortium phase 1 Data. (PubMed id 22293688)1 Huang J....Li Y. (2012)
    179. TGF-b-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex. (PubMed id 22560925)1 Thillainadesan G....Torchia J. (2012)
    180. Several mechanisms lead to the inactivation of the CDK N2A (P16), P14ARF, or CDKN2B (P15) genes in the GCB and ABC molecular DLBCL subt ypes. (PubMed id 22619049)1 Guney S....Bastard C. (2012)
    181. Genome-wide association meta-analysis identifies new e ndometriosis risk loci. (PubMed id 23104006)1 Nyholt D.R....Montgomery G.W. (2012)
    182. Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of bla st cells. (PubMed id 22772967)1 Kraguljac Kurtovic N....Krtolica K. (2012)
    183. Functional analyses of coronary artery disease associa ted variation on chromosome 9p21 in vascular smooth muscle cells. (PubMed id 22706276)1 Motterle A....Ye S. (2012)
    184. Genome-wide association study of coronary artery disea se in the Japanese. (PubMed id 21971053)1 Takeuchi F....Kato N. (2012)
    185. CDKN2B polymorphism is associated with primary open-an gle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies. (PubMed id 22761751)1 Cao D....Hejtmancik J.F. (2012)
    186. Analysis of p15INK4b and p16INK4a gene methylation in patients with oral squamous cell carcinoma. (PubMed id 22212460)1 Kordi-Tamandani D.M....Torkamanzehi A. (2012)
    187. Methylation of p15INK4b and expression of ANRIL on chr omosome 9p21 are associated with coronary artery disease. (PubMed id 23091611)1 Zhuang J....Xu Y. (2012)
    188. Genetic variants at the 9p21 locus contribute to ather osclerosis through modulation of ANRIL and CDKN2A/B. (PubMed id 22178423)1 Congrains A....Rakugi H. (2012)
    189. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)
    190. Monitoring of methylation changes in 9p21 region in pa tients with myelodysplastic syndromes and acute myeloid leukemia. (PubMed id 22248274)1 Cechova H....Cermak J. (2012)
    191. Common variants on chromosome 9p21 are associated with normal tension glaucoma. (PubMed id 22792221)1 Takamoto M....Tokunaga K. (2012)
    192. SNP in the genome-wide association study hotspot on ch romosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes. (PubMed id 22643932)1 Fagerholm E....Groop P.H. (2012)
    193. Genetic investigation into the endophenotypic status o f central corneal thickness and optic disc parameters in relation to open-angle glaucoma. (PubMed id 22840486)1 Dimasi D.P....Craig J.E. (2012)
    194. Long non-coding RNA ANRIL is required for the PRC2 re cruitment to and silencing of p15(INK4B) tumor suppressor gene. (PubMed id 21151178)1 Kotake Y....Xiong Y. (2011)
    195. A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia. (PubMed id 21414664)1 Iacobucci I....Martinelli G. (2011)
    196. Chromosome 7p11.2 (EGFR) variation influences glioma risk. (PubMed id 21531791)1 Sanson M....Simon M. (2011)
    197. Common genetic variants associated with open-angle gl aucoma. (PubMed id 21427129)1 Ramdas W.D....van Duijn C.M. (2011)
    198. CDKN2BAS is associated with periodontitis in differen t European populations and is activated by bacterial infection. (PubMed id 20978019)1 Schaefer A.S....Schreiber S. (2011)
    199. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1 Schunkert H....Samani N.J. (2011)
    200. DNA copy number profile discriminates between esophag eal adenocarcinoma and squamous cell carcinoma and represents an independent pr ognostic parameter in esophageal adenocarcinoma. (PubMed id 21757289)1 Rumiato E....Saggioro D. (2011)
    201. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    202. Association of six single nucleotide polymorphisms wit h gestational diabetes mellitus in a Chinese population. (PubMed id 22096510)1 Wang Y....Liu J. (2011)
    203. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    204. CDKN2A/B alterations impair prognosis in adult BCR-ABL 1-positive acute lymphoblastic leukemia patients. (PubMed id 22134481)1 Iacobucci I....Martinelli G. (2011)
    205. Genome-wide association study for coronary artery calc ification with follow-up in myocardial infarction. (PubMed id 22144573)1 O'Donnell C.J....Witteman J.C. (2011)
    206. Joint associations between genetic variants and repro ductive factors in glioma risk among women. (PubMed id 21920947)1 Wang S.S....Rajaraman P. (2011)
    207. Aberrant methylation of tumor suppressor genes in pat ients with refractory anemia with ring sideroblasts. (PubMed id 20864173)1 Valencia A....Sanz G.F. (2011)
    208. A common variant in the CDKN2B gene on chromosome 9p2 1 protects against coronary artery disease in Americans of African ancestry. (PubMed id 21270820)1 Kral B.G....Becker D.M. (2011)
    209. Cell-dependent kinase inhibitor 2A and 2B genetic var iability in patients with Alzheimer's disease. (PubMed id 21069533)1 Cortini F....Galimberti D. (2011)
    210. Prognostic significance of p14ARF, p15INK4b, and p16I NK4a inactivation in malignant peripheral nerve sheath tumors. (PubMed id 21262917)1 Endo M....Oda Y. (2011)
    211. Association of copy number loss of CDKN2B and PTCH1 w ith poor overall survival in patients with pulmonary squamous cell carcinoma. (PubMed id 21889114)1 Zhao Y....Zhu Z.Z. (2011)
    212. Glucose tolerance, insulin sensitivity and insulin re lease in European non-diabetic carriers of a polymorphism upstream of CDKN2A an d CDKN2B. (PubMed id 21234743)1 Hribal M.L....Sesti G. (2011)
    213. Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN 2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque. (PubMed id 20637465)1 Holdt L.M....Teupser D. (2011)
    214. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. (PubMed id 21573907)1 Parra E.J....Cruz M. (2011)
    215. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    216. Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffu se large B-cell lymphomas. (PubMed id 21638516)1 Guney S....Bastard C. (2011)
    217. Expression of linear and novel circular forms of an I NK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. (PubMed id 21151960)1 Burd C.E....Sharpless N.E. (2010)
    218. Epigenetic alterations of p15(INK4B) and p16(INK4A) g enes in pediatric primary myelodysplastic syndrome. (PubMed id 20658957)1 Rodrigues E.F....De Souza Fernandez T. (2010)
    219. Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks. (PubMed id 20663777)1 Camacho C.V....Burma S. (2010)
    220. Diabetes genes and prostate cancer in the Atheroscler osis Risk in Communities study. (PubMed id 20142250)4 Meyer T.E....Folsom A.R. (2010)
    221. [Phenylhexyl isothiocyanate induces gene p15 re-expre ssion by regulating histone methylation and DNA demethylation in Molt-4 cells]. (PubMed id 20561406)1 Ma X.D....Zheng R.J. (2010)
    222. p15INK4b methylation correlates with thrombocytopenia , blast percentage, and survival in myelodysplastic syndromes in a dose depende nt manner: quantitation using pyrosequencing study. (PubMed id 19782398)1 Kim M....Lee D.S. (2010)
    223. Genome-wide association study identifies five new bre ast cancer susceptibility loci. (PubMed id 20453838)1 Turnbull C....Easton D.F. (2010)
    224. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne Sanjose S. (2010)
    225. Polymorphisms in promoter sequences of the p15 ( INK4 B ) and PTEN genes of normal Japanese individuals. (PubMed id 20862607)1 Ohsaka Y....Nishino H. (2010)
    226. Genomic profiling of adult acute lymphoblastic leukem ia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. (PubMed id 20435627)1 Okamoto R....Koeffler H.P. (2010)
    227. Epigenetic regulation of the INK4b-ARF-INK4a locus: i n sickness and in health. (PubMed id 20716961)1 Popov N. and Gil J. (2010)
    228. Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide pol ymorphisms. (PubMed id 20889853)1 de Miguel-Yanes J.M....Meigs J.B. (2010)
    229. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    230. Strategies to re-express epigenetically silenced p15( INK4b) and p21(WAF1) genes in acute myeloid leukemia. (PubMed id 21124069)1 Geyer C.R. (2010)
    231. Up-regulation of activation-induced cytidine deaminas e causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. (PubMed id 20637757)1 Matsumoto Y....Chiba T. (2010)
    232. CDKN2A-CDKN2B deletion defines an aggressive subset o f cutaneous T-cell lymphoma. (PubMed id 20118908)1 Laharanne E....Merlio J.P. (2010)
    233. Frequency and clinical relevance of DNA microsatellit e alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pedi atric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia . (PubMed id 19586936)1 Krieger D....Burkhardt B. (2010)
    234. Common genetic polymorphisms in Moyamoya and atherosc lerotic disease in Europeans. (PubMed id 20694560)1 Roder C....Krischek B. (2010)
    235. Arsenic trioxide inhibits DNA methyltransferase and r estores expression of methylation-silenced CDKN2B/CDKN2A genes in human hematol ogic malignant cells. (PubMed id 20596618)1 Fu H.Y....Fan L.P. (2010)
    236. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1 Voight B.F.... . (2010)
    237. Differential gene expression in young and senescent e ndothelial cells under static and laminar shear stress conditions. (PubMed id 19409979)1 Mun G.I....Boo Y.C. (2009)
    238. Promoter methylation of P15(INK4B) gene is possibly a ssociated with parvovirus B19 infection in adult acute leukemias. (PubMed id 18384396)1 Yalcin A....Tezcan S. (2009)
    239. Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification. (PubMed id 19056724)1 Guo P....Dong J.T. (2009)
    240. MS-qFRET: a quantum dot-based method for analysis of DNA methylation. (PubMed id 19443857)1 Bailey V.J....Wang T.H. (2009)
    241. Deregulation of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in basal cell carcinoma. (PubMed id 19298278)1 Kanellou P....Spandidos D.A. (2009)
    242. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    243. Id2 suppression of p15 counters TGF-beta-mediated gro wth inhibition of melanoma cells. (PubMed id 19368689)1 Schlegel N.C....Hoek K.S. (2009)
    244. No association of multiple type 2 diabetes loci with type 1 diabetes. (PubMed id 19455305)4 Raj S.M....Todd J.A. (2009)
    245. Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia. (PubMed id 19109226)1 Yang H....Garcia-Manero G. (2009)
    246. Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood. (PubMed id 19484265)1 Novara F....Zuffardi O. (2009)
    247. Novel mutation of the cyclin-dependent kinase 4 gene in a Chinese patient with intimal sarcoma of the pulmonary artery. (PubMed id 19493449)1 Gao F....Zhang S. (2009)
    248. Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
    249. Preferentially different mechanisms of inactivation o f 9p21 gene cluster in liver fluke-related cholangiocarcinoma. (PubMed id 19200577)1 Chinnasri P....Limpaiboon T. (2009)
    250. Gene methylation in pleural mesothelioma: correlations with clinico-pathological features and patient's follow-up. (PubMed id 17920725)1 Destro A....Roncalli M. (2008)
    251. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. (PubMed id 18694974)1 van Hoek M....Janssens A.C. (2008)
    252. Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity. (PubMed id 18212765)1 Lindgren C.M. and McCarthy M.I. (2008)
    253. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. (PubMed id 18332116)1 Kia S.K....Verrijzer C.P. (2008)
    254. High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka. (PubMed id 18284544)1 Takeshima M....Abiko Y. (2008)
    255. Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. (PubMed id 18625718)1 Thillainadesan G....Torchia J. (2008)
    256. Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation. (PubMed id 18071362)1 Hallor K.H....Mertens F. (2008)
    257. The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrest. (PubMed id 17553787)1 Wall S.J....DeClerck Y.A. (2007)
    258. Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. (PubMed id 16909113)1 Weber R.G....Reifenberger G. (2007)
    259. Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia. (PubMed id 17074388)1 Ogawa M....Koike K. (2007)
    260. The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma. (PubMed id 17885492)1 Khouja M.H....Holm R. (2007)
    261. High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway. (PubMed id 17597576)1 Chen Y.H....Chuang L.Y. (2007)
    262. Epigenetic events underlie the pathogenesis of sinonasal papillomas. (PubMed id 17673925)1 Stephen J.K....Worsham M.J. (2007)
    263. Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma. (PubMed id 17900658)1 Chim C.S....Srivastava G. (2007)
    264. Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene. (PubMed id 17316622)1 Hitomi T....Sakai T. (2007)
    265. Aberrant methylation in pediatric myelodysplastic syndrome. (PubMed id 16890288)1 Vidal D.O....Vettore A.L. (2007)
    266. Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome. (PubMed id 16682076)1 Hofmann W.K....Koeffler H.P. (2006)
    267. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    268. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    269. Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia. (PubMed id 15978938)1 Canalli A.A....Garcia-Manero G. (2005)
    270. Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2. (PubMed id 15917995)1 Wen-Sheng W. and Jun-Ming H. (2005)
    271. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    272. [Expression and methylation of CpG islands in the pro moter of p15INK4B gene in children with acute myeloid leukemia] (PubMed id 15833197)1 Wen F.Q....Cao L.Z. (2005)
    273. Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage. (PubMed id 15580267)1 Wanzel M....Eilers M. (2005)
    274. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    275. Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. (PubMed id 15093610)1 Ho J....Lebrun J.J. (2004)
    276. Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer. (PubMed id 12684640)1 Yeh K.T....Shih M.C. (2003)
    277. p15(INK4b) in HDAC inhibitor-induced growth arrest. (PubMed id 14623092)1 Hitomi T....Sakai T. (2003)
    278. Reduced p16 expression correlates with lymphatic invasion in colorectal cancers. (PubMed id 14696398)1 Tada T....Nagawa H. (2003)
    279. Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. (PubMed id 12970781)1 Christiansen D.H....Pedersen-Bjergaard J. (2003)
    280. ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. (PubMed id 12592382)1 Wen-Sheng W. (2003)
    281. Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein. (PubMed id 12007796)1 Vogel L....Meijer L. (2002)
    282. Deletion analysis of p16(INKa) and p15(INKb) in relapsed childhood acute lymphoblastic leukemia. (PubMed id 12036898)1 Graf Einsiedel H....Seeger K. (2002)
    283. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    284. Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumors. (PubMed id 11692873)1 Orlow I. and Cordon-Cardo C. (2002)
    285. Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma. (PubMed id 12060387)1 Child F.J....Whittaker S.J. (2002)
    286. Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer. (PubMed id 11992549)1 Kudoh K....Uchida K. (2002)
    287. Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. (PubMed id 11695244)1 Agiostratidou G....Gonos E.S. (2001)
    288. Repression of p15INK4b expression by Myc through association with Miz-1. (PubMed id 11283613)1 Staller P....Eilers M. (2001)
    289. Expression of cyclin-dependent kinase inhibitor p15(I NK4B) during normal and leukemic myeloid differentiation. (PubMed id 10812241)1 Teofili L....Larocca L.M. (2000)
    290. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    291. Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma. (PubMed id 9815774)4 Gao L....Hogg D. (1997)
    292. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. (PubMed id 9163429)1 Iavarone A. and Massague J. (1997)
    293. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. (PubMed id 7478582)1 Hall M....Peters G. (1995)
    294. Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. (PubMed id 9399648)9 Iravani M....Price C.M. (1997)
    295. p15(INK4b) in bladder carcinomas: decreased expression in superficial tumours. (PubMed id 11720438)9 Le Frere-Belda M.A....Radvanyi F. (2001)
    296. Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines. (PubMed id 7547637)9 Zhou X....Meltzer S.J. (1995)
    297. Acquisition of p16(INK4A) and p15(INK4B) gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia. (PubMed id 10090949)9 Maloney K.W....Hunger S.P. (1999)
    298. Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16). (PubMed id 17283131)9 Markus J....Wolff L. (2007)
    299. Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression. (PubMed id 17258075)9 Scott S.A....DeCoteau J.F. (2007)
    300. The absence of the p15INK4B gene alterations in adult patients with precursor B-cell acute lymphoblastic leukaemia is a favourable prognostic factor. (PubMed id 12028019)9 Hoshino K....Mitsuya H. (2002)
    301. Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. (PubMed id 11764089)9 Wolter M....Reifenberger G. (2001)
    302. Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas. (PubMed id 10541865)9 Simon M....Schramm J. (1999)
    303. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. (PubMed id 9041181)9 Batova A....Yu A.L. (1997)
    304. Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance. (PubMed id 11413509)9 Chim C.S....Kwong Y.L. (2001)
    305. Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas. (PubMed id 9827724)9 Elisei R....Fagin J.A. (1998)
    306. Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations. (PubMed id 9737691)9 Maloney K.W....Hunger S.P. (1998)
    307. Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas. (PubMed id 9037130)9 Yoshimoto K....Itakura M. (1997)
    308. Deletion of the p16 and p15 genes in human bladder tumors. (PubMed id 7563186)9 Orlow I....Cordon-Cardo C. (1995)
    309. Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors. (PubMed id 7576106)9 Packenham J.P....Devereux T.R. (1995)
    310. Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. (PubMed id 7742529)9 Hatta Y....Koeffler H.P. (1995)
    311. [Impact of p16INK4A and p15INK4B on human hepatocellular carcinoma cell proliferation and apoptosis] (PubMed id 15079795)9 Qin Y....Sun Z.F. (2004)
    312. Molecular analysis of the INK4A and INK4B gene loci in human breast cancer cell lines and primary carcinomas. (PubMed id 11369056)9 Bisogna M....Van Zee K.J. (2001)
    313. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. (PubMed id 10939591)9 Fuxe J....Pettersson R.F. (2000)
    314. Deletion of p16 and p15 genes In schistosomiasis-associated bladder cancer (SABC). (PubMed id 10958872)9 Eissa S....Khalifa A. (2000)
    315. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. (PubMed id 9531610)9 Quesnel B....Fenaux P. (1998)
    316. Expression of p15INK4B in normal hematopoiesis. (PubMed id 9808052)9 Teofili L....Larocca L.M. (1998)
    317. Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. (PubMed id 8595411)9 Suzuki H....Abraham J.M. (1995)
    318. Promoter methylation status of p15 and p21 genes in HPP-CFCs of bone marrow of patients with psoriasis. (PubMed id 19153068)9 Zhang K....Niu X. (2009)
    319. Prognostic value of cell-cycle regulators and cellular biomarkers in laryngeal squamous cell carcinoma. (PubMed id 18602381)9 Swellam M....Adly A. (2008)
    320. Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene. (PubMed id 19014416)9 Candiloro I.L....Dobrovic A. (2008)
    321. Immunohistochemical expression of P15 (INK4B) and SMAD4 in advanced gastric cancer. (PubMed id 18507057)9 Sakellariou S....Pavlakis K. (2008)
    322. Adverse prognostic impact of CDKN2B hyper-methylation in acute promyelocytic leukemia. (PubMed id 16753865)9 Chim C.S. and Kwong Y.L. (2006)
    323. p15 (INK4B) and E-cadherin CpG island methylation is frequent in Egyptian acute myeloid leukemia. (PubMed id 17671532)9 El-Shakankiry N.H. and Mossallam G.I. (2006)
    324. Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma. (PubMed id 16343074)9 Fukai K....Saisho H. (2005)
    325. P16INK4A and p15INK4B gene alteration associated with oxidative stress in renal cell carcinomas after the chernobyl accident (pilot study). (PubMed id 12218456)9 Romanenko A....Llombart-Bosch A. (2002)
    326. Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas. (PubMed id 12213729)9 Garcia M.J....Rivas C. (2002)
    327. [Expression of p16INK4a, p15INK4b, p21WAF1/Clip1 cell cycle inhibitors on blastic cells in patients with acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) ] (PubMed id 12600181)9 Kapelko-Sl/owik K....Kuliczkowski K. (2002)
    328. Relationship of p15 and p16 gene alterations to elevated dihydrofolate reductase in childhood acute lymphoblastic leukaemia. (PubMed id 11380466)9 Shah S.J....Matherly L.H. (2001)
    329. Inactivation of the p14(ARF), p15(INK4B) and p16(INK4A) genes is a frequent event in human oral squamous cell carcinomas. (PubMed id 11435176)9 Shintani S....Matsumura T. (2001)
    330. Alternative splicing of the p15 cdk inhibitor in glioblastoma multiforme. (PubMed id 11563632)9 Simon M....Schramm J. (2001)
    331. Molecular analysis of tumor suppressor genes, Rb, p53, p16INK4A, p15INK4B and p14ARF in natural killer cell neoplasms. (PubMed id 11676855)9 Sakajiri S....Oshimi K. (2001)
    332. Cumulation of TP53 mutations and p16INK4A/p15INK4B homozygous deletions in human papilloma virus type 16 positive scrotal cancer. (PubMed id 10087941)9 GA1ran S. and Pak I. (1999)
    333. Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma. (PubMed id 10537333)9 Xing E.P....Yang C.S. (1999)
    334. Frequent methylation silencing of p15(INK4b) (MTS2) and p16(INK4a) (MTS1) in B-cell and T-cell lymphomas. (PubMed id 10477703)9 Baur A.S....Chaubert P. (1999)
    335. Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival. (PubMed id 9890173)9 Orlow I....Cordon-Cardo C. (1999)
    336. p16INK4 and p15INK4B alterations in primary gynecologic malignancy. (PubMed id 9159345)9 Wong Y.F....Chang A.M. (1997)
    337. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. (PubMed id 9116295)9 Ng M.H....Huang D.P. (1997)
    338. Alterations of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features. (PubMed id 9447829)9 Ohnishi H....Hayashi Y. (1997)
    339. Alterations of p16INK4A and p15INK4B genes in gastric carcinomas. (PubMed id 9366289)9 Lee Y.Y....Bang Y.J. (1997)
    340. Expression of the tumour suppressor genes p15 and p16 in malignant melanoma. (PubMed id 8873047)9 Robinson W.A....Hersey P. (1996)
    341. Abnormalities of p16, p15 and CDK4 genes in recurrent malignant astrocytomas. (PubMed id 8760309)9 Saxena A....Ali I.U. (1996)
    342. Partial deletions of the CDKN2 and MTS2 putative tumor suppressor genes in a myxoid chondrosarcoma. (PubMed id 8689636)9 Jagasia A.A....Iyer A.P. (1996)
    343. Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas. (PubMed id 8689637)9 Jagasia A.A....Iyer A.P. (1996)
    344. Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas. (PubMed id 7630644)9 Li Y.J....Hamelin R. (1995)
    345. Homozygous deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non-small cell lung cancers. (PubMed id 9816033)9 Packenham J.P....Devereux T.R. (1995)
    346. p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. (PubMed id 17713536)9 Krimpenfort P....Berns A. (2007)
    347. Deletions of p15 and p16 in schistosomal bladder cancer correlate with transforming growth factor-alpha expression. (PubMed id 15589816)9 Swellam M....AbuGabel K.M. (2004)
    348. The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR. (PubMed id 12932666)9 Wong T.S....Yuen A.P. (2003)
    349. Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. (PubMed id 11435325)9 Teofili L....Larocca L.M. (2001)
    350. Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. (PubMed id 11485924)9 Bostrom J....Reifenberger G. (2001)
    351. Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes. (PubMed id 10764143)9 Aoki E....Murate T. (2000)
    352. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. (PubMed id 10634644)9 Guo S.X....Hayashi Y. (2000)
    353. Abnormalities of tumor suppressor genes P16 and P15 in primary maxillofacial squamous cell carcinomas. (PubMed id 10432931)9 Zhao Y....Xiao C. (1999)
    354. Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China. (PubMed id 9934853)9 Xing E.P....Yang C.S. (1999)
    355. Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. (PubMed id 9554401)9 Heidenreich A....Srivastava S. (1998)
    356. Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. (PubMed id 9537438)9 Iolascon A....Della Ragione F. (1998)
    357. Hypermethylation of p15/ink4b/MTS2 gene is differentially implicated among non-Hodgkin's lymphomas. (PubMed id 9639423)9 Martinez-Delgado B....Benitez J. (1998)
    358. Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas. (PubMed id 8855819)9 Tahara H....Arnold A. (1996)
    359. Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. (PubMed id 7994022)9 Hebert J....Sigaux F. (1994)
    360. p15Ink4b: dual function in myelopoiesis and inactivation in myeloid disease. (PubMed id 18029205)9 Rosu-Myles M. and Wolff L. (2008)
    361. Promoter hypermethylation analysis in myelodysplastic syndromes: diagnostic & prognostic implication. (PubMed id 18316853)9 Solomon P.R....Shanmugam G. (2008)
    362. Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. (PubMed id 15851765)9 Bueso-Ramos C....Garcia-Manero G. (2005)
    363. Establishment and partial characterization of five malignant glioma cell lines. (PubMed id 15875906)9 Zhang L....Naganuma H. (2005)
    364. 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. (PubMed id 16010433)9 Matsuzaki Y....Sakai T. (2005)
    365. [Expression of PTKs CDK4 and p15 in the middle ear cholesteatomatous epithelium] (PubMed id 15620145)9 Sun W....Su J. (2004)
    366. Methylation profiling in multiple myeloma. (PubMed id 15109538)9 Chim C.S....Liang R. (2004)
    367. Cell cycle regulators in bladder cancer: relationship to schistosomiasis. (PubMed id 15590562)9 Eissa S....El-Ahmady O. (2004)
    368. Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias. (PubMed id 14513284)9 Chim C.S....Kwong Y.L. (2003)
    369. Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. (PubMed id 14681685)9 Wolff L....Perella C. (2003)
    370. Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis. (PubMed id 12750706)9 Teofili L....Larocca L.M. (2003)
    371. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. (PubMed id 12351408)9 Daskalakis M....Lubbert M. (2002)
    372. Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation. (PubMed id 11593429)9 Schmidt M....Wolff L. (2001)
    373. KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients. (PubMed id 11532526)9 Dodge J.E....List A.F. (2001)
    374. Analysis of cyclin-dependent kinase inhibitor expression and methylation patterns in human prostate cancers. (PubMed id 10797499)9 Nguyen T.T....Jones P.A. (2000)
    375. Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia. (PubMed id 10778944)9 Omura-Minamisawa M....Yu A.L. (2000)
    376. [Deletions and aberrant transcription of p16 and p15 genes in childhood acute lymphoblastic leukemia] (PubMed id 11721435)9 Fu G....Zhang R. (1999)
    377. [Homozygous deletion and methylation of p16 and p15 gene in acute leukemia] (PubMed id 11721412)9 Chen W....Zhu J. (1999)
    378. Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. (PubMed id 12894891)9 Yonghao T....Yandell D.W. (1999)
    379. Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma. (PubMed id 9536218)9 Wagner S.N....Goos M. (1998)
    380. Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb. (PubMed id 9697882)9 GrA...Ralfkiaer E. (1998)
    381. Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages. (PubMed id 9570245)9 Wu M.S....Lin J.T. (1998)
    382. Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma. (PubMed id 9616165)9 Elenitoba-Johnson K.S....Raffeld M. (1998)
    383. Absence of p15INK4B and p16INK4A gene alterations in primary cervical carcinoma tissues and cell lines with human papillomavirus infection. (PubMed id 9698478)9 Kim J.W....Kim I.K. (1998)
    384. Association of CDKN2A(p16)/CDKN2B(p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma. (PubMed id 9624535)9 Hamada K....Yokota J. (1998)
    385. Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation. (PubMed id 9792305)9 Wong I.H....Huang D.P. (1998)
    386. P53, p15INK4B, p16INK4A and p57KIP2 mutations during the progression of chronic myeloid leukemia. (PubMed id 10069444)9 Guran S....Yalcin A. (1998)
    387. Infrequent mutations and no methylation of CDKN2A (P16/MTS1) and CDKN2B (p15/MTS2) in hepatocellular carcinoma in Taiwan. (PubMed id 9893670)9 Lin Y.W....Sheu J.C. (1998)
    388. Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours. (PubMed id 9000591)9 Schmidt E.E....Collins V.P. (1997)
    389. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. (PubMed id 9041182)9 Herman J.G....Baylin S.B. (1997)
    390. Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma. (PubMed id 9012694)9 Tasaka T....Koeffler H.P. (1997)
    391. Establishment of a novel human B-cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes. (PubMed id 9600110)9 Nagai M....Takahara J. (1997)
    392. Alterations in the tumor suppressor genes p53, RB, p16/MTS1, and p15/MTS2 in human pancreatic cancer and hepatoma cell lines. (PubMed id 9058294)9 Kaino M. (1997)
    393. Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. (PubMed id 9269757)9 Uchida T....Murate T. (1997)
    394. Molecular analysis of the INK4 family of genes in prostate carcinomas. (PubMed id 9112579)9 Park D.J....Koeffler H.P. (1997)
    395. The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes. (PubMed id 8873383)9 Stadler W.M. and Olopade O.I. (1996)
    396. p16ink4a gene and hematological malignancies. (PubMed id 8724524)9 Quesnel B....Fenaux P. (1996)
    397. Inactivation of the p15INK4B and p16INK4 genes in hematologic malignancies. (PubMed id 9031104)9 Heyman M. and Einhorn S. (1996)
    398. Growth suppression of esophageal cancer cells by p16INK4 and p15INK4B in vitro. (PubMed id 9166536)9 Zhou X....Meltzer S.J. (1996)
    399. [Analysis of cyclin dependent kinase inhibitors, p16INK4a and p15INK4b gene, in acute lymphoblastic leukemias] (PubMed id 8816064)9 Kaname M....Gomi K. (1996)
    400. Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers. (PubMed id 8631583)9 Rusin M.R....Harris C.C. (1996)
    401. A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations. (PubMed id 8878451)9 Zhang S....Kumanishi T. (1996)
    402. p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia. (PubMed id 7780130)9 Rasool O....Einhorn S. (1995)
    403. Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2). (PubMed id 8587124)9 Jiang P....Kamb A. (1995)
    404. Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias. (PubMed id 7577621)9 Nakamaki T....Tsuruoka N. (1995)
    405. Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. (PubMed id 7606711)9 Xiao S....Fletcher J.A. (1995)
    406. p16INK4A and p15INK4B gene deletions in primary leukemias. (PubMed id 7795238)9 Haidar M.A....Albitar M. (1995)
    407. Codeletion of p15 and p16 in primary malignant mesothelioma. (PubMed id 7630635)9 Xio S....Fletcher J.A. (1995)
    408. Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines. (PubMed id 7577470)9 Southgate J....Selby P. (1995)
    409. Reexpression of epigenetically silenced AML tumor sup pressor genes by SUV39H1 inhibition. (PubMed id 19881540)9 Lakshmikuttyamma A....Geyer C.R. (2010)
    410. Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia. (PubMed id 15755284)9 Hasegawa D....Nakahata T. (2005)
    411. The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells. (PubMed id 14976051)9 Schmidt M....Wolff L. (2004)
    412. Consistent inactivation of p19(Arf) but not p15(Ink4b) in murine myeloid cells transformed in vivo by deregulated c-Myc. (PubMed id 12642863)9 Haviernik P....Wolff L. (2003)
    413. Translation of p15.5INK4B, an N-terminally extended and fully active form of p15INK4B, is initiated from an upstream GUG codon. (PubMed id 10763830)9 Fuxe J....Pettersson R.F. (2000)
    414. Mutations of p16 and p15 tumor suppressor genes and replication errors contribute independently to the pathogenesis of sporadic malignant melanoma. (PubMed id 9617435)9 Matsumura Y....Takebe H. (1998)
    415. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. (PubMed id 9639410)9 Drexler H.G. (1998)
    416. Deletion of P15 (MTS2) in head and neck squamous cell carcinomas. (PubMed id 9698532)9 Roesler J.M....Wang M.B. (1998)
    417. Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma. (PubMed id 9168184)9 Platz A....Ringborg U. (1997)
    418. Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. (PubMed id 9164185)9 Yamada Y....Tomonaga M. (1997)
    419. Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells. (PubMed id 9001419)9 Schwaller J....Tobler A. (1997)
    420. Analysis of the Rb gene and cyclin-dependent kinase 4 inhibitor genes (p16INK4 and p15INK4B) in human ovarian carcinoma cell lines. (PubMed id 9194486)9 Yaginuma Y....Ishikawa M. (1997)
    421. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. (PubMed id 8630377)9 Cayuela J.M....Sigaux F. (1996)
    422. Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma. (PubMed id 8703847)9 Iolascon A....Schettini F. (1996)
    423. Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors. (PubMed id 7585567)9 Linardopoulos S....Balmain A. (1995)
    424. Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. (PubMed id 7712460)9 Knapek D.F....Walker C.L. (1995)
    425. Tongue epithelial KT-1 cell-cycle arrest by TGF-beta associated with induction of p21(Cip1) and p15 (Ink4b). (PubMed id 20094776)9 Nakamura S....Ookura T. (2009)
    426. [Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro] (PubMed id 18718068)9 Yang L....Ding X.S. (2008)
    427. Aberrant gene promoter methylation in plasma cell dyscrasias. (PubMed id 18410922)9 Martin P....Bellas C. (2008)
    428. Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. (PubMed id 17438096)9 Zhang Y.J....Santella R.M. (2007)
    429. [Regulation of growth inhibition by transforming growth factor beta1 in rhabdomyosarcoma RD cell line] (PubMed id 15634452)9 Ye L....Wang H. (2004)
    430. [Growth and gene expression of leukemia cell after treated with methylation inhibitor 5-aza-2'-deoxycytidine] (PubMed id 15555266)9 Qiao S.K....Guo X.N. (2004)
    431. Evaluation of hypermethylated tumor suppressor genes as tumor markers in mouth and throat rinsing fluid, nasopharyngeal swab and peripheral blood of nasopharygeal carcinoma patient. (PubMed id 12767073)9 Chang H.W....Yuen A.P. (2003)
    432. Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma. (PubMed id 12672028)9 Viswanathan M....Shanmugam G. (2003)
    433. Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas. (PubMed id 12874790)9 Kawakami T....Okada Y. (2003)
    434. [p15 gene expression in acute lymphoblastic leukemia cell line Molt4 induced by arsenic trioxide] (PubMed id 11877046)9 Jin H....Yu L. (2001)
    435. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. (PubMed id 11283614)9 Seoane J....Massague J. (2001)
    436. Deletion of chromosomes 9p and 17 associated with abnormal expression of p53, p16/MTS1 and p15/MTS2 gene protein in hepatocellular carcinomas. (PubMed id 11776078)9 Shao J....Liew C. (2000)
    437. Alteration of p16 and p15 genes in common epithelial ovarian tumors. (PubMed id 9133447)9 Fujita M....Murata Y. (1997)
    438. Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion. (PubMed id 9044834)9 Gray-Bablin J....Keyomarsi K. (1997)
    439. The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. (PubMed id 9121451)9 Datto M.B....Wang X.F. (1997)
    440. Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. (PubMed id 8895759)9 Flores J.F....Fountain J.W. (1996)
    441. A frequent mutation/polymorphism in tumor suppressor gene INK4B (MTS-2) in papillary and medullary thyroid cancer. (PubMed id 8957499)9 Goretzki P.E....Roeher H.D. (1996)
    442. Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers. (PubMed id 8650244)9 Nobori T....Carson D.A. (1996)
    443. Deletion and transfection analysis of the p15/MTS2 gene in malignant gliomas. (PubMed id 8526910)9 Tenan M....Finocchiaro G. (1995)
    444. Infrequent somatic mutations of the p16 and p15 genes in human bladder cancer: p16 mutations occur only in low-grade and superficial bladder cancers. (PubMed id 8747595)9 Miyamoto H....Hosaka M. (1995)
    445. Homozygous loss of the p15INK4B gene (and not the p16INK4 gene) during tumor progression in a sporadic melanoma patient. (PubMed id 7585628)9 Glendening J.M....Fountain J.W. (1995)
    446. Homozygous deletions of p16INK4A/MTS1 and p15INK4B/MTS2 genes in glioma cells and primary glioma tissues. (PubMed id 7497469)9 Izumoto S....Hayakawa T. (1995)
    447. Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. (PubMed id 7606004)9 Takeuchi S....Schwaller J. (1995)
    448. Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients. (PubMed id 19818350)9 Iyer P....Soliman A.S. (2010)
    449. [Gene profiling after knocking-down the expression of NS gene in prostate cancer PC-3 cells] (PubMed id 20021940)9 Liu R.L....Li S.Z. (2009)
    450. TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1. (PubMed id 19022773)9 Spender L.C. and Inman G.J. (2009)
    451. Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors. (PubMed id 19330828)9 Kuo L.T....Tu Y.K. (2009)
    452. Aberrant promotor methylation in MDS hematopoietic cells during in vitro lineage specific differentiation is differently associated with DNMT isoforms. (PubMed id 18829110)9 Hopfer O....Hofmann W.K. (2009)
    453. Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with hepatitis C virus infection. (PubMed id 18492017)9 Hayashi T....Shiomi S. (2009)
    454. [The inhibition effect and its molecular mechanism of human cervical cancer oncogene siRNA on hepatocarcinoma cells] (PubMed id 18752750)9 Yang Y....Liu A.D. (2008)
    455. Double-minute MYC amplification and deletion of MTAP, CDKN2A, CDKN2B, and ELAVL2 in an acute myeloid leukemia characterized by oligonucleotide-array comparative genomic hybridization. (PubMed id 18503831)9 Kamath A....Li P. (2008)
    456. NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. (PubMed id 18348652)9 Chen X.J....Zhou S.Y. (2008)
    457. Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy. (PubMed id 18271923)9 Saito K....Kuwano H. (2008)
    458. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. (PubMed id 18185590)9 Yu W....Cui H. (2008)
    459. Aberrant methylation in promoter regions of cyclin-dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland. (PubMed id 18254776)9 Daa T....Yokoyama S. (2008)
    460. The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2. (PubMed id 18183498)9 Hu C.T....Wu W.S. (2008)
    461. Promoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma. (PubMed id 18723830)9 Ko E....Kim D.H. (2008)
    462. [Correlations of CpG island methylator phenotype and OPCML gene methylation to carcinogenesis of hepatocellular carcinoma] (PubMed id 16764763)9 Liu W.J....Yuan Y.F. (2006)
    463. Aberrant promoter hypermethylation profile of cell cycle regulatory genes in malignant astrocytomas. (PubMed id 17016577)9 Ohta T....Fukushima T. (2006)
    464. Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor. (PubMed id 16871886)9 Zhang L....Naganuma H. (2006)
    465. Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways. (PubMed id 17034532)9 Murao K....Arase S. (2006)
    466. [Deletion of p15 and pl6 genes and overexpression of STK15 gene in primary hepatocellular carcinoma] (PubMed id 15760556)9 Zhao J.M....Fu B.Y. (2005)
    467. [Clinical significance of the expression of DNA methyltransferase genes (DNMT) in acute leukemia patients.] (PubMed id 15854288)9 Qiao S.K....Wang Y. (2005)
    468. [Expression of six gene proteins in laryngeal carcinomas and their significance] (PubMed id 16248464)9 Wu X....Zhou L. (2005)
    469. Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation. (PubMed id 15833857)9 PAcrez de Castro I....Pellicer A. (2005)
    470. Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. (PubMed id 15970925)9 BAocklund L.M....Collins V.P. (2005)
    471. Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. (PubMed id 15467712)9 Yang B....Clark D.P. (2005)
    472. Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells. (PubMed id 14676836)9 Huang H....Tindall D.J. (2004)
    473. [Effect of overexpression of Smad7 gene on cell proliferation.] (PubMed id 15555279)9 Huo Y.Y....Wu D.C. (2004)
    474. Aberrant methylation of p14(ARF), p15(INK4b) and p16(INK4a) genes and location of the primary site in pulmonary squamous cell carcinoma. (PubMed id 15260845)9 Furonaka O....Inai K. (2004)
    475. Activation of expression of p15, p73 and E-cadherin in leukemic cells by different concentrations of 5-aza-2'-deoxycytidine (Decitabine). (PubMed id 15015578)9 Farinha N.J....Momparler R.L. (2004)
    476. [Association of homozygous deletion of p15 and p16 ge ne and amplification of EGFR gene in laryngeal squamous cell carcinoma] (PubMed id 15473298)9 Li F.C....Sun K.L. (2004)
    477. Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. (PubMed id 14719065)9 Lin S.Y....Chang J.G. (2004)
    478. Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. (PubMed id 15201966)9 Matsushita C....Taguchi H. (2004)
    479. [Deletion of p15 and p16 genes and overexpression of STK15 gene in human laryngeal squamous cell carcinoma] (PubMed id 12812651)9 Li F.C....Sun K.L. (2003)
    480. Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (PubMed id 14581362)9 Watanabe T....Yokoyama T. (2003)
    481. Differential gene methylation in undifferentiated nasopharyngeal carcinoma. (PubMed id 12632081)9 Wong T.S....Yuen A.P. (2003)
    482. Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance. (PubMed id 12899712)9 Chim C.S....Kwong Y.L. (2003)
    483. Aberrant promoter CpG methylation as a molecular marker for disease monitoring in natural killer cell lymphomas. (PubMed id 12823347)9 Siu L.L....Kwong Y.L. (2003)
    484. Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN. (PubMed id 14519639)9 Backlund L.M....Collins V.P. (2003)
    485. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. (PubMed id 11839665)9 Chan M.W....To K.F. (2002)
    486. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. (PubMed id 11801549)9 Kwong J....Huang D.P. (2002)
    487. Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. (PubMed id 11167795)9 Tien H.F....Shen M.C. (2001)
    488. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. (PubMed id 11413518)9 Leung W.K....Sung J.J. (2001)
    489. [Detection of hypermethylation of p15 gene in patients with acute leukemia by polymerase chain reaction] (PubMed id 11876990)9 Chen F. and Zeng X. (2000)
    490. Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation. (PubMed id 10997979)9 Furukawa Y....Matsuda M. (2000)
    491. [Mechanism of resistance to growth inhibition by transforming growth factor-beta 1 (TGF-beta 1) in primary lung cancer and new molecular targets in therapy] (PubMed id 10945024)9 Gemma A....Kudoh S. (2000)
    492. Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway. (PubMed id 10454538)9 Warner B.J....Massague J. (1999)
    493. Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia. (PubMed id 10071127)9 Kawamura M....Hayashi Y. (1999)
    494. Deletion of p16INK4A/CDKN2 and p15INK4B in human somatic cell hybrids and hybrid-derived tumors. (PubMed id 9950215)9 Kuerbitz S.J....Graff J.R. (1999)
    495. The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity. (PubMed id 10066746)9 Sun J....Sebti S.M. (1999)
    496. The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. (PubMed id 10585406)9 Hu P.P....Wang X.F. (1999)
    497. p53 and p16INK4A mutations during the progression of glomus tumor. (PubMed id 10079377)9 GA1ran S. and Tali E.T. (1999)
    498. Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-beta-induced cell cycle arrest of gastric carcinoma cells. (PubMed id 10376964)9 Kang S.H....Kim S.J. (1999)
    499. Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins. (PubMed id 10362250)9 Sangfelt O....Grander D. (1999)
    500. Structural and functional analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in neuroblastoma. (PubMed id 9432125)9 Iolascon A....Ragione F.D. (1998)
    501. Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma. (PubMed id 9591637)9 Dreyling M.H....Olopade O.I. (1998)
    502. The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. (PubMed id 9466670)9 Prins J.B....Versnel M.A. (1998)
    503. Differential myeloma cell responsiveness to interferon-alpha correlates with differential induction of p19(INK4d) and cyclin D2 expression. (PubMed id 9565604)9 Arora T. and Jelinek D.F. (1998)
    504. Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds. (PubMed id 9416844)9 Flores J.F....Fountain J.W. (1997)
    505. The commonly deleted region at 9p21-22 in lymphoblastic leukemias spans at least 400 kb and includes p16 but not p15 or the IFN gene cluster. (PubMed id 9009086)9 Aguiar R.C....Cross N.C. (1997)
    506. De novo methylation of tumour suppressor genes CDKN2A and CDKN2B is a rare finding in B-cell chronic lymphocytic leukaemia. (PubMed id 9375748)9 Martel V....Jonveaux P. (1997)
    507. Comparative detection and quantitation of human CDK inhibitor mRNA expression of p15INK4B, p16INK4A, p16beta, p18INK4C, p19INK4D, p21WAF1, p27KIP1 and p57KIP2 by RT-PCR using a polycompetitive internal standard. (PubMed id 9432039)9 Schwaller J....Tobler A. (1997)
    508. [Alteration of p15 and p16 gene in gastric cancer] (PubMed id 9263516)9 Fushida S....Miyazaki I. (1997)
    509. Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. (PubMed id 9393981)9 Kovar H....Gadner H. (1997)
    510. Absence of p18 mutations or deletions in lymphoid malignancies. (PubMed id 8637248)9 Otsuki T....Raffeld M. (1996)
    511. Expression of CDK inhibitor genes in immortalized and carcinoma derived breast cell lines. (PubMed id 8712723)9 Zhou J.N. and Linder S. (1996)
    512. Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors. (PubMed id 8621248)9 Sato K....Ohgaki H. (1996)
    513. Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. (PubMed id 7478613)9 Nakagawa K....Kelley M.J. (1995)
    514. Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. (PubMed id 7882348)9 Otsuki T....Raffeld M. (1995)
    515. Oligonucleotide array-CGH identifies genomic subgroup s and prognostic markers for tumor stage mycosis fungoides. (PubMed id 19759554)9 Salgado R....Espinet B. (2010)
    516. Deletion at chromosome arm 9p in relation to BRAF/NRA S mutations and prognostic significance for primary melanoma. (PubMed id 20140953)9 Conway C....Newton-Bishop J.A. (2010)
    517. Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia. (PubMed id 20237504)9 Deneberg S....Lehmann S. (2010)
    518. Spectral karyotypic and comparative genomic analysis of the endocrine pancreatic tumor cell line BON-1. (PubMed id 19887762)9 Lopez J.R....Speel E.J. (2010)
    519. Tocotrienols inhibited growth and induced apoptosis i n human HeLa cells through the cell cycle signaling pathway. (PubMed id 20150225)9 Wu S.J. and Ng L.T. (2010)
    520. Epigenetic changes in therapy-related MDS/AML. (PubMed id 19874806)9 Voso M.T....Leone G. (2010)
    521. CTCF is a DNA methylation-sensitive positive regulato r of the INK/ARF locus. (PubMed id 20051228)9 Rodriguez C....Piette J. (2010)
    522. Multi-step aberrant CpG island hyper-methylation is a ssociated with the progression of adult T-cell leukemia/lymphoma. (PubMed id 20019193)9 Sato H....Yoshino T. (2010)
    523. Genome-wide high-resolution analysis of DNA copy numb er alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array. (PubMed id 19603524)9 Mantripragada K.K....Upadhyaya M. (2009)
    524. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (PubMed id 19208363)9 Trobridge P....Grady W.M. (2009)
    525. High-resolution analysis of aberrant regions in autos omal chromosomes in human leukemia THP-1 cell line. (PubMed id 19635138)9 Adati N....Kojima T. (2009)
    526. Relationship between CAD risk genotype in the chromos ome 9p21 locus and gene expression. Identification of eight new ANRIL splice va riants. (PubMed id 19888323)9 Folkersen L....Eriksson P. (2009)
    527. Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis. (PubMed id 19056458)9 Liou S.F....Yeh J.L. (2009)
    528. Expression of p18(INK4C) is Down-regulated in Human Pituitary Adenomas. (PubMed id 19401813)9 Hossain M.G....Yoshimoto K. (2009)
    529. DNA hypermethylation profiles in squamous cell carcinoma of the vulva. (PubMed id 19047905)9 Stephen J.K....Worsham M.J. (2009)
    530. Accumulation of aberrant CpG hypermethylation by Heli cobacter pylori infection promotes development and progression of gastric MALT lymphoma. (PubMed id 19639175)9 Kondo T....Yoshino T. (2009)
    531. Varying etiologies lead to different molecular change s in Australian and South African hepatocellular carcinomas. (PubMed id 19787262)9 Herath N.I....MacDonald G.A. (2009)
    532. Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma. (PubMed id 19060847)9 Sinn D.H....Kim K.M. (2009)
    533. The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation. (PubMed id 18923142)9 Cheng F....Zagon I.S. (2009)
    534. Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. (PubMed id 18539616)9 Amara K....Korbi S. (2008)
    535. Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. (PubMed id 17977648)9 Singh A.P....Batra S.K. (2008)
    536. Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma. (PubMed id 18712977)9 Alhebshi H.M....Mabruk M.J. (2008)
    537. Reprimo as a potential biomarker for early detection in gastric cancer. (PubMed id 18829507)9 Bernal C....Corvalan A.H. (2008)
    538. Losses of 3p14 and 9p21 as shown by fluorescence in situ hybridization are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis. (PubMed id 18163473)9 Schwarz S....Brockhoff G. (2008)
    539. Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma. (PubMed id 18310086)9 Christensen B.C....Kelsey K.T. (2008)
    540. A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. (PubMed id 18413836)9 Klisovic R.B....Marcucci G. (2008)
    541. Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. (PubMed id 18264082)9 Vivekanandan P. and Torbenson M. (2008)
    542. Circulating DNA in the blood of gastric cancer patients. (PubMed id 18837952)9 Kolesnikova E.V....Rykova E.Y. (2008)
    543. Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. (PubMed id 18241037)9 Chen J....Fan J.B. (2008)
    544. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. (PubMed id 18523155)9 Kroeger H....Issa J.P. (2008)
    545. Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays. (PubMed id 18519675)9 Nancarrow D.J....Whiteman D.C. (2008)
    546. Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. (PubMed id 18938072)9 RamA-rez N....GarcA-a-Foncillas J. (2008)
    547. Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs). (PubMed id 18438954)9 Haller F....FA1zesi L. (2008)
    548. [Detection of p15 gene methylation or deletion status in different malignant cell lines by using hemi-nested methylation specific polymerase chain reaction] (PubMed id 17493352)9 Lin F.A....Fan L.P. (2007)
    549. DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. (PubMed id 17549390)9 Oh B.K....Park Y.N. (2007)
    550. Characterization of genetic alteration patterns in hu man esophageal squamous cell carcinoma using selected microsatellite markers sp anning multiple loci. (PubMed id 17390007)9 Cai Y.C....Yang C.S. (2007)
    551. Modeling INK4/ARF tumor suppression in the mouse. (PubMed id 17311533)9 Berger J.H. and Bardeesy N. (2007)
    552. Reduced XPC messenger RNA level may predict a poor outcome of patients with nonsmall cell lung cancer. (PubMed id 17508409)9 Wu Y.H....Lee H. (2007)
    553. Quantitative high-resolution CpG island mapping with Pyrosequencing reveals disease-specific methylation patterns of the CDKN2B gene in myelodysplastic syndrome and myeloid leukemia. (PubMed id 17095538)9 Brakensiek K....Lehmann U. (2007)
    554. [Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes] (PubMed id 17369979)9 Zavala G L....Corvalan R A. (2007)
    555. Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome. (PubMed id 17350682)9 BogdanoviA8 G....PopoviA8 S. (2007)
    556. DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation. (PubMed id 17577921)9 Hopfer O....Hofmann W.K. (2007)
    557. Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. (PubMed id 17784872)9 Yamaguchi T....Sakai T. (2007)
    558. High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. (PubMed id 17997817)9 Klein-Scory S....Schwarte-Waldhoff I. (2007)
    559. HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese. (PubMed id 17454594)9 Au W.Y....Liang R. (2007)
    560. Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses. (PubMed id 17206475)9 Muhlisch J....Fruhwald M.C. (2007)
    561. Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. (PubMed id 17376510)9 Milne A.N....Weterman M.A. (2007)
    562. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. (PubMed id 17230231)9 Jost E....Galm O. (2007)
    563. CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. (PubMed id 16707594)9 Chang M.S....Fukayama M. (2006)
    564. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. (PubMed id 16537562)9 Peng D.F....Hirohashi S. (2006)
    565. The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951. (PubMed id 16818274)9 Mirebeau D....Cave H. (2006)
    566. Inactivation of CDKN2A, CDKN2B and MTAP in childhood B-lineage acute lymphobastic leukemia. (PubMed id 16818264)9 Beverloo H.B. (2006)
    567. Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas. (PubMed id 16989737)9 Gray S.E....Mabruk M. (2006)
    568. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. (PubMed id 16928264)9 Yang H.J....Ngan H.Y. (2006)
    569. Glucocorticoid up-regulates transforming growth factor-beta (TGF-beta) type II receptor and enhances TGF-beta signaling in human prostate cancer PC-3 cells. (PubMed id 16887915)9 Li Z....Lu J. (2006)
    570. Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. (PubMed id 16081515)9 Hellerbrand C....Bosserhoff A.K. (2006)
    571. The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (PubMed id 17043023)9 Sarasquete M.E....San Miguel J.F. (2006)
    572. Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma. (PubMed id 16616114)9 Michalowski M.B....Plantaz D. (2006)
    573. A FoxO-Smad synexpression group in human keratinocytes. (PubMed id 16908841)9 Gomis R.R....MassaguAc J. (2006)
    574. Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing. (PubMed id 16185764)9 Nagasawa T....Wasik M.A. (2006)
    575. Molecular and cytogenetic subgroups of oropharyngeal squamous cell carcinoma. (PubMed id 17121883)9 Perrone F....Pilotti S. (2006)
    576. Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia. (PubMed id 16039715)9 Yang Y....Koeffler H.P. (2006)
    577. Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. (PubMed id 16369045)9 Cheng Y.W....Barany F. (2006)
    578. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. (PubMed id 16505103)9 Mantena S.K....Katiyar S.K. (2006)
    579. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. (PubMed id 16140969)9 Burdette J.E....Woodruff T.K. (2005)
    580. Probing the chromosome 9p21 region susceptible to DNA double-strand breaks in human cells in vivo by restriction enzyme transfer. (PubMed id 16007206)9 Sato M....Kohno T. (2005)
    581. In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages. (PubMed id 15738662)9 Lowenheim H....Knipper M. (2005)
    582. Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells. (PubMed id 15839997)9 Wang L....Colbert M.C. (2005)
    583. Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia. (PubMed id 15755503)9 Kumagai T....Koeffler H.P. (2005)
    584. Absence of p16 and p27 gene rearrangements and mutations in de novo myelodysplastic syndromes. (PubMed id 16104874)9 Papageorgiou S.G....Economopoulos T. (2005)
    585. Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. (PubMed id 15753386)9 Panopoulou E....Fotsis T. (2005)
    586. Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells. (PubMed id 16322252)9 Hu X....Manni A. (2005)
    587. Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival. (PubMed id 15837753)9 GrafstrAPm E....Platz A. (2005)
    588. Characterization of Sno expression in malignant melanoma. (PubMed id 15809735)9 Poser I....Bosserhoff A.K. (2005)
    589. Clinical experience with decitabine in North American patients with myelodysplastic syndrome. (PubMed id 16273408)9 Yee K.W....Giles F.J. (2005)
    590. Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas. (PubMed id 15892004)9 Liu Y....Ng H.K. (2005)
    591. Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia. (PubMed id 15737564)9 Tsellou E....Petridou E. (2005)
    592. Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. (PubMed id 16192589)9 Roman-Gomez J....Torres A. (2005)
    593. Progressive methylation during the serrated neoplasia pathway of the colorectum. (PubMed id 15389252)9 Dong S.M....Kim K.M. (2005)
    594. Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPA): Its usefulness as an adjunctive diagnostic tool for melanocytic tumors. (PubMed id 16054806)9 Takata M....Saida T. (2005)
    595. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer. (PubMed id 15942635)9 Leung W.K....Sung J.J. (2005)
    596. Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. (PubMed id 15164098)9 Inoue R....Wade-Martins R. (2004)
    597. Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK. (PubMed id 14971655)9 Ceryak S....Patierno S.R. (2004)
    598. Role for BRG1 in cell cycle control and tumor suppression. (PubMed id 14673169)9 Hendricks K.B....Lees E. (2004)
    599. Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. (PubMed id 14688019)9 Lindsey J.C....Clifford S.C. (2004)
    600. DNA methylation changes in multiple myeloma. (PubMed id 15318245)9 Galm O....Osieka R. (2004)
    601. Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21-23 in the biology of favourable stage 4 tumours. (PubMed id 15305192)9 Mora J....Gerald W.L. (2004)
    602. Systematic multiplex polymerase chain reaction and reverse transcription-polymerase chain reaction analyses of changes in copy number and expression of proto-oncogenes and tumor suppressor genes in cancer tissues and cell lines. (PubMed id 15490458)9 Yamamoto M....Yamamoto F. (2004)
    603. Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas. (PubMed id 15531468)9 Gallardo F....Servitje O. (2004)
    604. Molecular pathogenesis of meningiomas. (PubMed id 15674477)9 Perry A....Reifenberger G. (2004)
    605. DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. (PubMed id 15197802)9 Seidl S....ZAPchbauer-MA1ller S. (2004)
    606. Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. (PubMed id 14647420)9 Han S.U....Kim S.J. (2004)
    607. High-throughput method for detecting DNA methylation. (PubMed id 15262448)9 Hou P....Lu Z. (2004)
    608. High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population. (PubMed id 14732922)9 Hu N....Goldstein A.M. (2004)
    609. Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. (PubMed id 15477587)9 Scandura J.M....Nimer S.D. (2004)
    610. Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma. (PubMed id 15221997)9 Chang H.W....Yuen A.P. (2004)
    611. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (PubMed id 15367334)9 Yu J....Zhu J. (2004)
    612. CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. (PubMed id 15154012)9 GutiAcrrez M.I....Bhatia K. (2004)
    613. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. (PubMed id 15526363)9 Xu X.L....Zhu J.D. (2004)
    614. Hypermethylation of CpG islands in primary and metastatic human prostate cancer. (PubMed id 15026333)9 Yegnasubramanian S....Nelson W.G. (2004)
    615. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. (PubMed id 15198948)9 Roman-Gomez J....Torres A. (2004)
    616. p14ARF, p15INK4b and p16INK4a methylation status in chronic myelogenous leukemia. (PubMed id 15370242)9 Kusy S....Roche J. (2004)
    617. Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma. (PubMed id 15073117)9 Wong T.S....Yuen A.P. (2004)
    618. Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. (PubMed id 15386372)9 Bai A.H....Leung W.K. (2004)
    619. Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia. (PubMed id 15495254)9 Ekmekci C.G....Bhatia K. (2004)
    620. Cell cycle regulators at the ocular surface. (PubMed id 15106924)9 Zieske J.D....Guo X. (2004)
    621. NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner. (PubMed id 15588951)9 Slupianek A. and Skorski T. (2004)
    622. Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup. (PubMed id 12970785)9 Gutierrez M.I....Bhatia K. (2003)
    623. Epigenetic targets in hematopoietic malignancies. (PubMed id 14528273)9 Claus R. and LA1bbert M. (2003)
    624. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. (PubMed id 12554760)9 Yao M.W....Maas R.L. (2003)
    625. Aberrant methylation in promoter-associated CpG islan ds of multiple genes in therapy-related leukemia. (PubMed id 12888905)9 Uehara E....Koeffler H.P. (2003)
    626. Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells. (PubMed id 12559313)9 Kawakami T....Okada Y. (2003)
    627. Clinical and genetic characteristics of Japanese Burkitt lymphomas with or without leukemic presentation. (PubMed id 12841388)9 Namiki T....Kaneko Y. (2003)
    628. Detection of cell-cycle regulators in failed arteriovenous fistulas for haemodialysis. (PubMed id 12637654)9 de Graaf R....Tordoir J.H. (2003)
    629. Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia. (PubMed id 12548613)9 Garcia-Manero G....Issa J.P. (2003)
    630. Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. (PubMed id 12845670)9 Edamoto Y....Ohgaki H. (2003)
    631. Deregulation of the RB pathway in human testicular germ cell tumours. (PubMed id 12754735)9 Bartkova J....Bartek J. (2003)
    632. Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. (PubMed id 12875987)9 Behrmann I....Bosserhoff A.K. (2003)
    633. Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors. (PubMed id 12963998)9 Obana K....Hayashi Y. (2003)
    634. Characterization of gastrin-induced cytostatic effect on cell proliferation in experimental malignant gliomas. (PubMed id 12657185)9 Lefranc F....Kiss R. (2003)
    635. Mutation analysis of candidate genes in melanoma-prone families: evidence of different pathogenetic mechanisms at chromosome 9P21. (PubMed id 14646620)9 Casula M....Palmieri G. (2003)
    636. [Effects of hexamethylene bisacetamide on cell cycle and expression of its regulatory proteins in HL-60 cells] (PubMed id 14575541)9 Wang Q.H....Liu Y. (2003)
    637. TGF beta1 induces multiple independent signals to regulate human trophoblastic differentiation: mechanistic insights. (PubMed id 12943995)9 Rama S....Rao A.J. (2003)
    638. Distinct methylation profiles of glioma subtypes. (PubMed id 12794756)9 Uhlmann K....Laird P.W. (2003)
    639. CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia. (PubMed id 12661005)9 Bertin R....Cave H. (2003)
    640. [Effects of two LMP1 variants on resistance of CNE1 cell strain to TGF-beta1] (PubMed id 14693046)9 Huang H. and Huang P.C. (2003)
    641. Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions. (PubMed id 12959350)9 Lossos I.S. and Levy R. (2003)
    642. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. (PubMed id 12937151)9 Yang B....Clark D.P. (2003)
    643. Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. (PubMed id 12565816)9 Gartel A.L. and Shchors K. (2003)
    644. [Homozygous deletion of p16 and p15 genes in laryngeal squamous cell carcinoma] (PubMed id 11836682)9 Li F....Sun K. (2002)
    645. Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study. (PubMed id 11853794)9 Hofmann W.K....Ottmann O.G. (2002)
    646. Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation. (PubMed id 11960918)9 Smeds J....Kumar R. (2002)
    647. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. (PubMed id 12448005)9 To K.F....Sung J.J. (2002)
    648. Cyclin D-dependent kinases, INK4 inhibitors and cancer. (PubMed id 11960696)9 Ortega S....Barbacid M. (2002)
    649. [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1] (PubMed id 12667347)9 Tong H. and Lin M. (2002)
    650. Cell cycle control genes and hematopoietic cell differentiation. (PubMed id 11999551)9 Furukawa Y. (2002)
    651. Hypermethylation of the p15(INK4B) gene in acute leukemia and myelodysplastic syndromes. (PubMed id 12150726)9 Chen H. and Wu S. (2002)
    652. Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. (PubMed id 11840272)9 Kulkarni M.S....Williams M.E. (2002)
    653. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. (PubMed id 12143052)9 Roncalli M....Coggi G. (2002)
    654. Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. (PubMed id 11945174)9 Yoon G....Lee J.H. (2002)
    655. Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms. (PubMed id 12460470)9 Sugimoto K.J....Oshimi K. (2002)
    656. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. (PubMed id 12433278)9 Yu J....Zhu J. (2002)
    657. Hypermethylation of gene promoters in hematological neoplasia. (PubMed id 12469326)9 Chim C.S....Kwong Y.L. (2002)
    658. [Inhibitory effect on proliferation of KG1a cell line by methyltransferase inhibitors] (PubMed id 12513759)9 Chen H....Wang J.Z. (2002)
    659. Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. (PubMed id 11325847)9 Matsushima-Nishiu M....Nakamura Y. (2001)
    660. Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors. (PubMed id 11487055)9 Dong S.M....Ng H.K. (2001)
    661. Molecular genetic abnormalities in premalignant lung lesions: biological and clinical implications. (PubMed id 11432708)9 Niklinski J....Pluygers E. (2001)
    662. Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas. (PubMed id 11642545)9 Nam D.H....Kim J.H. (2001)
    663. p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells. (PubMed id 11795482)9 Draus J.M....McMasters K.M. (2001)
    664. One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus. (PubMed id 11704876)9 Gilley J. and Fried M. (2001)
    665. A long distance-PCR derived FISH probe detects a deletion between p15 and p16 in CML and T-ALL patients. (PubMed id 11351270)9 Bleichert A....von Eggeling F. (2001)
    666. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. (PubMed id 11423975)9 Dauphinot L....Delattre O. (2001)
    667. [Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of medulloblastoma--results of a genomewide methylation scan] (PubMed id 11528554)9 FrA1hwald M.C....Plass C. (2001)
    668. Dynamic DNA methylation change in the CpG island regi on of p15 during human myeloid development. (PubMed id 11602627)9 Sakashita K....Kubota T. (2001)
    669. Repression of human reduced folate carrier gene expression by wild type p53. (PubMed id 11106643)9 Ding B.C....Matherly L.H. (2001)
    670. [Molecular mechanisms controlling the cell cycle: fundamental aspects and implications for oncology] (PubMed id 11355576)9 Viallard J.F....Reiffers J. (2001)
    671. A PCR-Based Method for Studying DNA Methylation. (PubMed id 12843452)9 Ariel M. (2001)
    672. Bladder cancer. I. Molecular and genetic basis of carcinogenesis. (PubMed id 11464028)9 Brandau S. and BAPhle A. (2001)
    673. Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia. (PubMed id 11243384)9 Uchida T....Saito H. (2001)
    674. Primary malignant lymphoma of the brain: analysis of MMAC1 (PTEN) tumor suppressor gene. (PubMed id 11908870)9 Ding X....Kumanishi T. (2001)
    675. A gene hypermethylation profile of human cancer. (PubMed id 11309270)9 Esteller M....Herman J.G. (2001)
    676. A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2. (PubMed id 11581254)9 Prall O.W....Sutherland R.L. (2001)
    677. Increased expression of p27Kip1 arrests neuroblastoma cell growth. (PubMed id 11464914)9 Matsuo T....Thiele C.J. (2001)
    678. Atherosclerosis and cancer: common molecular pathways of disease development and progression. (PubMed id 11795276)9 Ross J.S....Ginsburg G.S. (2001)
    679. H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism. (PubMed id 10698496)9 Delgado M.D....LeA^n J. (2000)
    680. Clonality analysis by methylation-specific PCR for the human androgen-receptor gene (HUMARA-MSP). (PubMed id 10637497)9 Uchida T....Kinoshita T. (2000)
    681. Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line. (PubMed id 10721718)9 Pacheco T.R....Maxwell I.H. (2000)
    682. Malignant hematopoietic cell lines: in vitro models for the study of myelodysplastic syndromes. (PubMed id 10654445)9 Drexler H.G. (2000)
    683. Anti-sense oligonucleotide of p21(waf1/cip1) prevents interleukin 4-mediated elevation of p27(kip1) in low grade astrocytoma cells. (PubMed id 10698511)9 Liu J....Barna B.P. (2000)
    684. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. (PubMed id 11126361)9 Schmid M....Carson D.A. (2000)
    685. Cyclin A down-regulation in TGFbeta1-arrested follicular lymphoma cells. (PubMed id 11082295)9 Djaborkhel R....MA1ller J. (2000)
    686. Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells. (PubMed id 10896783)9 Hsu S.L....Chang C.D. (2000)
    687. High frequency of loss of heterozygosity on chromosome region 9p21-p22 but lack of p16INK4a/p19ARF mutations in greek patients with basal cell carcinoma of the skin. (PubMed id 10998150)9 Saridaki Z....Spandidos D.A. (2000)
    688. Dissociation of bone morphogenetic protein-mediated growth arrest and apoptosis of mouse B cells by HPV-16 E6/E7. (PubMed id 10854068)9 Yamato K....Nishihara T. (2000)
    689. Aneuploidy of chromosome 9 and the tumor suppressor g enes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally adva nced prostate cancer. (PubMed id 11025389)9 Heidenreich B....Sesterhenn I.A. (2000)
    690. [Mechanism of tumorigenesis caused by tumor suppressor gene] (PubMed id 10879046)9 Hayashi Y. (2000)
    691. Analysis of G(1)/S checkpoint regulators in metastatic melanoma. (PubMed id 10862049)9 Sauroja I....Pyrhonen S. (2000)
    692. Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. (PubMed id 10884382)9 Jin Y.H....Lee S.K. (2000)
    693. Stem cell factor inhibits erythroid differentiation by modulating the activity of G1-cyclin-dependent kinase complexes: a role for p27 in erythroid differentiation coupled G1 arrest. (PubMed id 10845428)9 Tamir A....Ben-David Y. (2000)
    694. Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas. (PubMed id 10773403)9 Zhuang S.M....SAPderkvist P. (2000)
    695. Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells. (PubMed id 10338330)9 Rizos H....Mann G.J. (1999)
    696. DNA methylation changes and multiple myeloma. (PubMed id 10492069)9 Ng M.H....Lo K.W. (1999)
    697. Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity. (PubMed id 10207089)9 Tsubari M....Laiho M. (1999)
    698. Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex. (PubMed id 9927424)9 Ellis M....Mittnacht S. (1999)
    699. Comparative molecular genetic profiles of anaplastic astrocytomas/glioblastomas multiforme and their subsequent recurrences. (PubMed id 10022821)9 Saxena A....Ali I.U. (1999)
    700. The cyclin-dependent kinase inhibitors p18INK4c and p19INK4d are highly expressed in CD34+ progenitor and acute myeloid leukaemic cells but not in normal differentiated myeloid cells. (PubMed id 10468852)9 Tschan M.P....Tobler A. (1999)
    701. Deletions of the INK4A gene in superficial bladder tumors. Association with recurrence. (PubMed id 10393843)9 Orlow I....Cordon-Cardo C. (1999)
    702. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. (PubMed id 9916800)9 Cameron E.E....Baylin S.B. (1999)
    703. [Study on the methylation of p15 gene CpG islands in acute leukemia: using methylation-specific PCR method] (PubMed id 11721363)9 Zhang Y....Yu L. (1999)
    704. The prognostic significance of p16INK4a/p14ARF and p15INK4b deletions in adult acute lymphoblastic leukemia. (PubMed id 10430092)9 Faderl S....Albitar M. (1999)
    705. Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C). (PubMed id 10556039)9 Yuan C.... Tsai M.-D. (1999)
    706. [Mutations of several tumor suppressor genes in primary retinoblastoma] (PubMed id 11776785)9 Huang Q....Yandell D.W. (1999)
    707. Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model. (PubMed id 10490845)9 Kazianis S....Nairn R.S. (1999)
    708. Orthotopic models of human pancreatic cancer. (PubMed id 10415855)9 CapellA! G....LluA-s F. (1999)
    709. TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression. (PubMed id 9863014)9 Voss M....Naumann M. (1999)
    710. Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas. (PubMed id 10416984)9 Buschges R....Reifenberger G. (1999)
    711. Establishment and characterization of 12 human colorectal-carcinoma cell lines. (PubMed id 10362137)9 Oh J.H....Park J.G. (1999)
    712. Establishment of two glioma cell lines from two surgical specimens obtained at different times from the same individual. (PubMed id 10359144)9 Onda K....Kumanishi T. (1999)
    713. TaqMan PCR-based gene dosage assay for predictive testing in individuals from a cancer family with INK4 locus haploinsufficiency. (PubMed id 10388473)9 Laurendeau I....Vidaud D. (1999)
    714. Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway. (PubMed id 10469453)9 Berner J.M....Lothe R.A. (1999)
    715. Establishment and characterization of human laryngeal squamous cell carcinoma cell lines. (PubMed id 10369293)9 Ku J.L....Park J.G. (1999)
    716. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. (PubMed id 10073286)9 Tsihlias J....Slingerland J. (1999)
    717. Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma. (PubMed id 10086736)9 Moller M.B....Pedersen N.T. (1999)
    718. Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (PubMed id 9973227)9 van Dekken H....Rosenberg C. (1999)
    719. Induced differentiation of U937 cells by 1,25-dihydroxyvitamin D3 involves cell cycle arrest in G1 that is preceded by a transient proliferative burst and an increase in cyclin expression. (PubMed id 10194452)9 Rots N.Y....Freedman L.P. (1999)
    720. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. (PubMed id 10446989)9 Melki J.R....Clark S.J. (1999)
    721. Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia. (PubMed id 10512159)9 Matherly L.H. and Taub J.W. (1999)
    722. Germ-line deletion involving the INK4 locus in familial proneness to melanoma and nervous system tumors. (PubMed id 9622062)9 Bahuau M....Vidaud M. (1998)
    723. Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines. (PubMed id 9790510)9 Kumar R....Hemminki K. (1998)
    724. The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia. (PubMed id 9426690)9 Hori Y....Nobori T. (1998)
    725. Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. (PubMed id 9598804)9 Walker G.J....Fountain J.W. (1998)
    726. Expression of cell cycle regulatory genes in chronic myelogenous leukemia. (PubMed id 9825572)9 Iolascon A....Faienza M.F. (1998)
    727. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. (PubMed id 9843571)9 Shen X....Wang X.F. (1998)
    728. Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence. (PubMed id 9704925)9 Erickson S....GrandAcr D. (1998)
    729. High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene. (PubMed id 10036997)9 Uchida T....Murate T. (1998)
    730. Insensitivity to growth inhibition by TGF-beta1 correlates with a lack of inhibition of the CDK2 activity in prostate carcinoma cells. (PubMed id 9794232)9 Cipriano S.C. and Chen Y.Q. (1998)
    731. Alterations in DNA methylation: a fundamental aspect of neoplasia. (PubMed id 9338076)9 Baylin S.B....Issa J.P. (1998)
    732. Rare loss of heterozygosity of the MTS1 and MTS2 tumor suppressor genes in differentiated human thyroid cancer. (PubMed id 9808321)9 Schulte K.M....RAPher H.D. (1998)
    733. Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines. (PubMed id 9673367)9 Fujishita T....Kobayashi M. (1998)
    734. Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). (PubMed id 9782052)9 Baumgartner R....Holak T.A. (1998)
    735. [Inhibitors of cyclins/CDK of the 9p21 chromosomal region and malignant hemopathies] (PubMed id 9817058)9 Quesnel B. (1998)
    736. Molecular comparison of human and mouse pulmonary adenocarcinomas. (PubMed id 9659582)9 Malkinson A.M. (1998)
    737. Immediate onset of DNA synthesis in remnant rat liver after 90% hepatectomy by an administration of follistatin. (PubMed id 9875645)9 Kogure K....Kojima I. (1998)
    738. Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia. (PubMed id 9446664)9 Gardie B....Sigaux F. (1998)
    739. An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes. (PubMed id 9501299)9 Malumbres M....Pellicer A. (1998)
    740. Selective variegated methylation of the p15 CpG island in acute myeloid leukemia. (PubMed id 9808523)9 Dodge J.E....Futscher B.W. (1998)
    741. Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia. (PubMed id 9422538)9 Chilosi M....Inghirami G. (1998)
    742. Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells. (PubMed id 9486855)9 Guo Y. and Kyprianou N. (1998)
    743. Shortened survival after relapse in T-cell acute lymphoblastic leukemia patients with p16/p15 deletions. (PubMed id 9279366)9 Diccianni M.B....Yu A.L. (1997)
    744. Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma. (PubMed id 9378820)9 GonzA!lez M.V....Coto E. (1997)
    745. Allelic loss determination in chronic lymphocytic leukemia by immunomagnetic bead sorting and microsatellite marker analysis. (PubMed id 9018124)9 Gartenhaus R.B. (1997)
    746. Deletion and differential expression of p16INK4a in mouse lung tumors. (PubMed id 9054597)9 Belinsky S.A....Tesfaigzi J. (1997)
    747. DNA methylation changes in hematologic malignancies: biologic and clinical implications. (PubMed id 9130685)9 Issa J.P....Herman J.G. (1997)
    748. Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-alpha in hematopoietic cell lines. (PubMed id 9053838)9 Sangfelt O....GrandAcr D. (1997)
    749. Inactivation of cyclin-dependent kinase inhibitor genes and development of human acute leukemias. (PubMed id 9130611)9 Ragione F.D. and Iolascon A. (1997)
    750. The role of proto-oncogenes in coronary restenosis. (PubMed id 9327828)9 Muller D.W. (1997)
    751. Effects of exogenous p16INK4a on growth of cells with various status of cell-cycle regulators. (PubMed id 9177281)9 Suzuki-Takahashi I....Kitagawa M. (1997)
    752. Analysis of p18INK4C in adult T-cell leukaemia and non-Hodgkin's lymphoma. (PubMed id 9401081)9 Hatta Y....Koeffler H.P. (1997)
    753. Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes. (PubMed id 9111168)9 Nakamaki T....Koeffler H.P. (1997)
    754. Primary malignant lymphoma of the brain: demonstration of frequent p16 and p15 gene deletions. (PubMed id 8698617)9 Kumanishi T....Washiyama K. (1996)
    755. Sensitivity to transforming growth factor beta 1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC down-regulation and p21waf1 induction are important early events. (PubMed id 8891333)9 Malliri A....Ozanne B. (1996)
    756. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. (PubMed id 8760298)9 Loughran O....Parkinson E.K. (1996)
    757. Exclusive p15INK4B gene deletions in acute lymphocytic leukemia include the E1 beta exon of the p16INK4 gene. (PubMed id 8608263)9 Heyman M....SAPderhAoll S. (1996)
    758. Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors. (PubMed id 8934552)9 Zariwala M. and Xiong Y. (1996)
    759. Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood. (PubMed id 8683987)9 Ohnishi H....Hayashi Y. (1996)
    760. Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines. (PubMed id 9414383)9 Kitahara K....Tahara E. (1996)
    761. Altered regulation of G1 cyclins in oxidant-induced growth arrest of lung alveolar epithelial cells. Accumulation of inactive cyclin E-DCK2 complexes. (PubMed id 8810266)9 Corroyer S....Clement A. (1996)
    762. A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. (PubMed id 8656689)9 Heyman M....Johansson B. (1996)
    763. Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. (PubMed id 8622065)9 Heyman M....Einhorn S. (1996)
    764. The gene for multiple familial trichoepithelioma maps to chromosome 9p21. (PubMed id 8752837)9 Harada H....Ko M.S. (1996)
    765. Mutational analysis of the p15 and p16 genes in acute leukaemias. (PubMed id 8616035)9 Sill H....Cross N.C. (1996)
    766. Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan. (PubMed id 8957063)9 Wu M.S....Lin J.T. (1996)
    767. Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies. (PubMed id 8652807)9 Hangaishi A....Hirai H. (1996)
    768. [Analysis of the p16INK4, p15INK4B genes abnormality and the amplification of cyclin D1 gene in esophageal cancer] (PubMed id 8920671)9 Takamura H....Miyazaki I. (1996)
    769. Role of the cyclin-dependent kinase 4 and 6 inhibitor gene family p15, p16, p18 and p19 in leukemia and lymphoma. (PubMed id 9031081)9 Siebert R....Opalka B. (1996)
    770. Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas. (PubMed id 8912526)9 Shi S.T. (1996)
    771. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. (PubMed id 8631003)9 Herman J.G....Baylin S.B. (1996)
    772. [Cyclin-dependent kinase inhibitors in mammal cells] (PubMed id 9592231)9 Jiang H. and Wang Y.C. (1996)
    773. A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism. (PubMed id 8847892)9 Urashima M....Anderson K.C. (1996)
    774. TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip 1. (PubMed id 8957087)9 FlA...Slingerland J.M. (1996)
    775. Cyclin-dependent kinase inhibitors (CKIs) and hematological malignancies. (PubMed id 8891723)9 Baghdassarian N. and Ffrench M. (1996)
    776. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. (PubMed id 8790415)9 Herman J.G....Baylin S.B. (1996)
    777. Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines. (PubMed id 8797888)9 Akama Y....Tahara E. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
    Free Text  

      Query String
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1030 HGNC: 1788 AceView: CDKN2AandCDKN2B Ensembl:ENSG00000147883 euGenes: HUgn1030
    ECgene: CDKN2B Kegg: 1030 H-InvDB: CDKN2B

    (According to HUGE)
    About This Section

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    PharmGKB entry for CDKN2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDKN2B gene:
    Search GeneIP for patents involving CDKN2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN2B
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of CDKN2B
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

     Antibodies for CDKN2B (p15INK4b/CDKN2B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDKN2B   OriGene RNAi products in human, mouse, rat for CDKN2B  
     OriGene qPCR primer pairs and template standards for CDKN2B   OriGene Protein Over-expression Lysate for CDKN2B  
     OriGene MassSpec something-or-other for CDKN2B   OriGene clones in human, mouse for CDKN2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDKN2B   OriGene Purified Protein for CDKN2B  
     OriGene ORF clones in mouse, rat for CDKN2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDKN2B   OriGene Custom Protein Services for CDKN2B  

     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDKN2B
     QIAGEN SeqTarget long-range PCR primers for resequencing CDKN2B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN2B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B
     GenScript Custom Purified and Recombinant Proteins Services for CDKN2B GenScript cDNA clones with any tag delivered in your preferred vector for CDKN2B
     GenScript CDKN2B-Activity-based Kinase Assay for Compound Screening GenScript Custom Superior Antibodies Services for CDKN2B
     GenScript Custom overexpressing Cell Line Services for CDKN2B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDKN2B promoter
     Search Chromatin IP Primers for CDKN2B
     RT2 qPCR Primer Assay in human, mouse, rat CDKN2B
     GNC Network for CDKN2B
     SABiosciences PCR Arrays including human, mouse, rat CDKN2B
     Search Tocris compounds for CDKN2B (CDN2B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CDKN2B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDKN2B antibodies
     CDKN2B proteins
     CDKN2B lysates
     Antibodies for CDKN2B
     See all of Abcam's Antibodies, Kits and Proteins for CDKN2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins

     Proteins for CDKN2B
     Antibodies for CDKN2B
     ELISAs for CDKN2B
     CLIAs for CDKN2B
     Cell Line associated with CDKN2B: PureStem ES-210, Ecto-ntu Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B
     SwitchGear 3'UTR luciferase reporter plasmids for CDKN2B
     SwitchGear Promoter luciferase reporter plasmids for CDKN2B
     ThermoFisher Antibodies for CDKN2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDKN2B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDKN2B
     lentivirus for stable overexpression of CDKN2B
     lentivirus expression plasmids for stable overexpression of CDKN2B
     adenovirus for overexpression of CDKN2B
     LSBio Antibodies in human, mouse, rat for CDKN2B
    Customized transgenic rodents for:
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDKN2B gene at Home site.
    hostname: index build: 106 solr: 1.4