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CDKN2B Gene

protein-coding   GIFtS: 68
GCID: GC09M021992

Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)1 2     CDK Inhibitory Protein2
MTS22 3 5     CDK4B Inhibitor2
Multiple Tumor Suppressor 22 3     Cyclin-Dependent Kinase 4 Inhibitor B2
MTS-22 3     Cyclin-Dependent Kinases 4 And 6 Binding Protein2
p14-INK4b2 3     p14_INK4B2
p15-INK4b2 3     P14_CDK Inhibitor2
INK4B2 5     P15 CDK Inhibitor2
P152 5     p15INK4b2
CDK4I2     p15_INK4B2
TP152     p15INK4B3

External Ids:    HGNC: 17881   Entrez Gene: 10302   Ensembl: ENSG000001478837   OMIM: 6004315   UniProtKB: P427723   

Export aliases for CDKN2B gene to outside databases

Previous GC identifers: GC09M022331 GC09M022204 GC09M021994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKN2B Gene:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in
a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4
or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth
regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically
induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively
spliced transcript variants of this gene, which encode distinct proteins, have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDKN2B Gene:
CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) is a protein-coding gene. Diseases associated with CDKN2B include thyroid lymphoma, and acute lymphoblastic leukemia, childhood. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
cycle arrest

Gene Wiki entry for CDKN2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN2B gene promoter:
         PPAR-gamma1   Sp1   p53   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN2B promoter sequence
   Search Chromatin IP Primers for CDKN2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p21

CDKN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M021992:  view genomic region     (about GC identifiers)

Start:
22,002,902 bp from pter      End:
22,009,362 bp from pter
Size:
6,461 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4 inhibitor B  
Size: 138 amino acids; 14722 Da
Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6
Secondary accessions: O15125 Q6FI09
Alternative splicing: 2 isoforms:  P42772-1   P42772-2   

Explore the universe of human proteins at neXtProt for CDKN2B: NX_P42772

Explore proteomics data for CDKN2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDKN2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004927.2  NP_511042.1  

    ENSEMBL proteins: 
     ENSP00000276925   ENSP00000369487   ENSP00000445136  
    Reactome Protein details: P42772

    CDKN2B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDKN2B

    CDKN2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN2B
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    Abcam antibodies for CDKN2B
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    ThermoFisher Antibodies for CDKN2B
    LSBio Antibodies in human, mouse, rat for CDKN2B

    CDKN2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CDKN2B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDKN2B
    Cloud-Clone Corp. CLIAs for CDKN2B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P42772

    ProtoNet protein and cluster: P42772

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family
    Similarity: Contains 4 ANK repeats


    CDKN2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN2B_HUMAN, P42772
    Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell
    cycle arrest

         Genatlas biochemistry entry for CDKN2B:
    cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1
    checkpoint,tightly linked and highly homolog to CDKN2A

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity NAS9230210
    GO:0005515protein binding IPI16169070
    GO:0019901protein kinase binding IPI8078588
         
    CDKN2B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDKN2B:
     Decreased cilium length  Decreased cilium length after   Decreased telomerase activity  Increased cell number in G2M,  

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdkn2b):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system 
     tumorigenesis 

    CDKN2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDKN2B: Cdkn2btm1Bbd Cdkn2btm1Brn Cdkn2a/Cdkn2bCdkn2a/tm1Brn Cdkn2a/Cdkn2bCdkn2a/tm2Brn Cdkn2btm2Brn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKN2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDKN2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDKN2B:
    hsa-mir-375 (MIRT019955), hsa-mir-98-5p (MIRT027714), hsa-mir-374b-5p (MIRT016027)

    Block miRNA regulation of human, mouse, rat CDKN2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKN2B (see all 25):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDKN2B
    Predesigned siRNA for gene silencing in human, mouse, rat CDKN2B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CDKN2B (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2B (NM_004936)
    Sino Biological Human cDNA Clone for CDKN2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B

    Cell Line
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    ESI BIO PureStem Progenitor for CDKN2B: 
    PureStem ES-210, Ecto-ntu Progenitor
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDN2B_HUMAN, P42772: Cytoplasm. Note=Also found in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA16943770
    GO:0005829cytosol TAS--

    CDKN2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKN2B About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    3Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    4Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDKN2B
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Pancreatic Adenocarcinoma

    3 GeneGo (Thomson Reuters) Pathways for CDKN2B
        Cell cycle Regulation of G1/S transition (part 1)
    Development Role of Activin A in cell differentiation and proliferation
    Development TGF-beta receptor signaling

    5 BioSystems Pathways for CDKN2B
        G1 to S cell cycle control
    Signaling Pathways in Glioblastoma
    Integrated Pancreatic Cancer Pathway
    Regulation of nuclear SMAD2/3 signaling
    Validated targets of C-MYC transcriptional repression


    5 Reactome Pathways for CDKN2B
        Oxidative Stress Induced Senescence
    Senescence-Associated Secretory Phenotype (SASP)
    Oncogene Induced Senescence
    Cyclin D associated events in G1
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


    Selected Kegg Pathways  (Kegg details for CDKN2B) (see all 7):
        FoxO signaling pathway
    Cell cycle
    TGF-beta signaling pathway
    HTLV-I infection
    Pathways in cancer


    CDKN2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2B (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDKN2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDKN2B (P427721, 2, 3 ENSP000002769254) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-711280,EBI-295644 MINT-8251348 I2D: score=6 STRING: ENSP00000257904
    CDK8P493363, ENSP000003709384I2D: score=1 STRING: ENSP00000370938
    CDK6Q005341, ENSP000002657344EBI-711280,EBI-295663 STRING: ENSP00000265734
    ZBTB17Q131053, ENSP000003648954I2D: score=1 STRING: ENSP00000364895
    MAGEA11P433643, ENSP000003473584I2D: score=4 STRING: ENSP00000347358
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA8078588
    GO:0000086G2/M transition of mitotic cell cycle IMP17553787
    GO:0000278mitotic cell cycle TAS--
    GO:0001889liver development IEA--
    GO:0006351transcription, DNA-templated TAS--

    CDKN2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKN2B (CDN2B)

    Selected Novoseek inferred chemical compound relationships for CDKN2B gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methylthioadenosine 75.7 10 18163473 (1), 12661005 (1), 16618910 (1), 19272367 (1) (see all 7)
    5-aza-2'deoxycytidine 70.4 28 12351408 (3), 18718068 (3), 19881540 (2), 15015578 (2) (see all 12)
    sodium bisulfite 64.2 3 17369979 (1), 9808523 (1), 10637497 (1)
    tgf beta1 18.1 5 16871886 (2), 14693046 (1), 11082295 (1)
    5-methylcytosine 16.1 1 9808523 (1)
    o6-methylguanine 15.9 2 15197802 (1)
    retinoic acid 7.43 3 10896783 (1), 15839997 (1)
    pd 98,059 7.28 2 16322252 (1), 17513607 (1)
    arsenite 4.79 3 11877046 (3)
    azathioprine 2.25 1 15015578 (1)



    CDKN2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDKN2B gene (2 alternative transcripts): 
    NM_004936.3  NM_078487.2  

    Unigene Cluster for CDKN2B:

    Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
    Hs.72901  [show with all ESTs]
    Unigene Representative Sequence: NM_078487
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276925(uc003zpn.3 uc003zpo.3) ENST00000579591 ENST00000380142
    ENST00000539462(uc022beo.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDKN2B (see all 25):
    hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCDKN2B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN2B (NM_004936)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2B
    Primer
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    OriGene qPCR primer pairs and template standards for CDKN2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CDKN2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKN2B
      QuantiTect SYBR Green Assays in human, mouse, rat CDKN2B
      QuantiFast Probe-based Assays in human, mouse, rat CDKN2B

    Additional mRNA sequence: 

    AF004819.1 AF488409.1 AF488410.1 AF488411.1 AF488731.1 BC014469.1 BC018984.2 CR536529.1 
    L36844.1 U17075.1 

    5 DOTS entries:

    DT.40207564  DT.91660559  DT.121147154  DT.75102662  DT.95150832 

    Selected AceView cDNA sequences (see all 264):

    BM719878 BF000057 NM_078487 BM126144 AF488409 BM843979 CR604976 CB160611 
    CK904818 BM831598 AU279609 BM701855 CR536529 BQ002393 BM055160 N44213 
    AA826886 AF004819 BC014469 BG031050 BX502404 AW328497 NM_004936 AF488410 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for CDKN2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDKN2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCTGCTT
    CDKN2B Expression
    About this image


    CDKN2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Granulosa Cells Primary Follicle
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    CDKN2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKN2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72901

    UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772
    Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN2B (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDKN2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CDKN2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKN2B
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    QuantiFast Probe-based Assays in human, mouse, rat CDKN2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN2B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn2b1 , 5 cyclin-dependent kinase inhibitor 2B (p15, inhibits more1, 5 84.37(n)1
    88.28(a)1
      4 (42.15 cM)5
    125791  NM_007670.41  NP_031696.11 
     893062895 
    chicken
    (Gallus gallus)
    Aves CDKN2B1 cyclin-dependent kinase inhibitor 2B (p15, inhibits more 70.03(n)
    63.87(a)
      395076  NM_204433.1  NP_989764.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    2(61354501-61364127)


    ENSEMBL Gene Tree for CDKN2B (if available)
    TreeFam Gene Tree for CDKN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKN2B gene
    CDKN2A2  CDKN2C2  CDKN2D2  
    10 SIMAP similar genes for CDKN2B using alignment to 4 protein entries:     CDN2B_HUMAN (see all proteins):
    p15    CDKN2A    p14ARF    p16ink4a    CDKN2D    CDKN2C
    ANKRD54    TNKS2    ANKRD28    ANKRD65

    CDKN2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKN2B (see all 211)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0014894
    Lung adenocarcinoma4--see VAR_0014892 A V mis40--------
    VAR_0014884
    Lung adenocarcinoma4--see VAR_0014882 G E mis40--------
    rs1474873281,2
    --21997231(+) AATTAC/TAGAAT 2 -- ds50010--------
    rs726936181,2
    C--21997246(+) AAAAAA/GAAAAA 2 -- ds50010--------
    rs32179951,2
    C,F--21997326(-) ACTTAC/-ACTGA 2 -- ds50011Minor allele frequency- -:0.02NS 170
    rs1400639651,2
    --21997487(+) GGCGTC/TTGGGG 2 -- ds50010--------
    rs32179941,2
    C,F,H--21997633(-) CACCTA/GAGTGG 2 -- ds500120Minor allele frequency- G:0.07NS EA NA WA 2093
    rs1817364501,2
    --21997829(+) CAGGAA/CTCATG 2 -- ut310--------
    rs32179931,2
    C--21997938(-) CCACCT/CGGCAG 2 -- ut31 ese32Minor allele frequency- C:0.01NS NA 156
    rs32179921,2
    C,F,H--21997992(-) GTATTG/AAAATA 2 -- ut3130Minor allele frequency- A:0.34NS EA NA WA 3159

    HapMap Linkage Disequilibrium report for CDKN2B (22002902 - 22009362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDKN2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8426CNV Loss18304495
    nsv892748CNV Loss21882294
    nsv824877CNV Loss20364138
    nsv892746CNV Loss21882294
    nsv892745CNV Gain21882294
    nsv892747CNV Gain21882294

    Human Gene Mutation Database (HGMD): CDKN2B
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CDKN2B:
    Oncogenes & Tumor Suppressor Genes 384HC
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing CDKN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600431    OMIM disorders: --

    Selected diseases for CDKN2B (see all 131):    
    About MalaCards
    thyroid lymphoma    acute lymphoblastic leukemia, childhood    skin melanoma    multiple familial trichoepithelioma
    laryngeal squamous cell carcinoma    pleomorphic xanthoastrocytoma    adult acute lymphocytic leukemia    primary malignant lymphoma
    diffuse astrocytoma    coronary restenosis    anaplastic oligodendroglioma    lymphoblastic lymphoma
    ewing's family of tumors    oligodendroglioma    anaplastic astrocytoma    wermer syndrome
    acute leukemia    myelodysplastic syndromes    childhood leukemia    melanoma, malignant, somatic

    1 disease from the University of Copenhagen DISEASES database for CDKN2B:
    Cancer

    CDKN2B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CDKN2B gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 70.7 14 16140969 (1), 17513607 (1), 9058294 (1), 9327828 (1) (see all 13)
    tumors 68.2 350 7563186 (5), 11764089 (4), 8689637 (4), 9816033 (4) (see all 99)
    t-all 67.9 39 9041181 (5), 9399648 (4), 10778944 (4), 8630377 (2) (see all 15)
    myelodysplastic syndromes 66 21 17095538 (2), 9269757 (2), 9531610 (2), 11167795 (2) (see all 13)
    multiple tumors 64.3 3 8957063 (1), 9827724 (1), 9698532 (1)
    allelic imbalance 62.4 7 18564286 (1), 18712977 (1), 18331779 (1)
    lymphoblastic leukemia acute 61.2 29 7780130 (2), 7994022 (2), 8683987 (1), 8816064 (1) (see all 22)
    allelic loss 61.1 6 7780130 (1), 9501299 (1), 11874489 (1), 8855819 (1)
    primary tumor 60.1 12 7882348 (1), 8760309 (1), 9698478 (1), 8689636 (1) (see all 9)
    lymphoblastic leukemia acute childhood 58.2 14 9399648 (2), 9737691 (2), 8816064 (1), 12661005 (1) (see all 8)

    Genetic Association Database (GAD): CDKN2B
    Human Genome Epidemiology (HuGE) Navigator: CDKN2B (146 documents)

    Export disorders for CDKN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKN2B gene, integrated from 10 sources (see all 804) (see top 10):
    (articles sorted by number of sources associating them with CDKN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PubMed id 8078588)1, 2, 3, 9 Hannon G.J. and Beach D. (Nature 1994)
    2. Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)1, 4, 9 Soto MartA-nez J.L....LA^pez-Nevot M.A. (amp 2005)
    3. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (PubMed id 7882351)1, 2, 9 Okamoto A.... Harris C.C. (Cancer Res. 1995)
    4. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. (PubMed id 19141585)1, 4, 9 Agarwal S.K....Marx S.J. (J. Clin. Endocrinol. Metab. 2009)
    5. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. (PubMed id 17008550)1, 4, 9 Healy J....Sinnett D. (Blood 2007)
    6. MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. (PubMed id 19272367)1, 4, 9 Yang X.C....Wang X.F. (Clin. Biochem. 2009)
    7. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. (PubMed id 19690970)1, 4, 9 Chen J....Frazier M.L. (amp 2009)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (Clin. Cancer Res. 2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    10. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PubMed id 17928989)1, 4, 9 Horikoshi M....Kadowaki T. (Diabetologia 2007)
    11. Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma. (PubMed id 17909067)1, 4, 9 Ruiz-Llorente S....Robledo M. (Cancer Res. 2007)
    12. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PubMed id 17409409)1, 4, 9 Gayther S.A....Pharoah P.D. (Cancer Res. 2007)
    13. Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. (PubMed id 10892805)1, 2, 9 Yuan C.... Tsai M.D. (Protein Sci. 2000)
    14. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)1, 2, 9 Guan K.-L.... Xiong Y. (Genes Dev. 1994)
    15. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. (PubMed id 22419738)1, 4 Osman W....Nakamura Y. (Hum. Mol. Genet. 2012)
    16. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    17. A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. (PubMed id 19501493)1, 4 Junyent M....Ordovas J.M. (Nutr Metab Cardiovasc Dis 2010)
    18. Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. (PubMed id 20802253)1, 4 Heni M....HAoring H.U. (Diabetes 2010)
    19. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010)
    20. Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort. (PubMed id 20616309)1, 4 Pechlivanis S....Moebus S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    21. Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. (PubMed id 19794065)1, 4 Lango Allen H....Weedon M.N. (Diabetes 2010)
    22. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (Diabetologia 2010)
    23. Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. (PubMed id 20386740)1, 4 Cunnington M.S....Keavney B. (PLoS Genet. 2010)
    24. Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study. (PubMed id 20043145)1, 4 Ruchat S.M....PAcrusse L. (Diabetologia 2010)
    25. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. (PubMed id 20512145)1, 4 Bei J.X....Zeng Y.X. (Nat. Genet. 2010)
    26. Genome-wide association study of intracranial aneurysm identifies three new risk loci. (PubMed id 20364137)1, 4 Yasuno K....GA1nel M. (Nat. Genet. 2010)
    27. Interaction between 5 genetic variants and allergy in glioma risk. (PubMed id 20462933)1, 4 Schoemaker M.J....Swerdlow A.J. (Am. J. Epidemiol. 2010)
    28. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    29. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PubMed id 20574843)1, 4 Yang X.R....Goldstein A.M. (Fam. Cancer 2010)
    30. Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. (PubMed id 19933996)1, 4 Zhao J....Grant S.F. (Diabetes 2010)
    31. Detecting rare variants for complex traits using family and unrelated data. (PubMed id 19847924)1, 4 Zhu X....Elston R.C. (Genet. Epidemiol. 2010)
    32. Genetic risk profiles identify different molecular etiologies for glioma. (PubMed id 20847058)1, 4 Simon M....Sanson M. (Clin. Cancer Res. 2010)
    33. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. (PubMed id 20509872)1, 4 Han X....Ji L. (BMC Med. Genet. 2010)
    34. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (PubMed id 20712903)1, 4 Morgan A.R....Mitchell E.A. (BMC Med. Genet. 2010)
    35. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. (PubMed id 20550665)1, 4 Lin Y....Yang Z. (BMC Med. Genet. 2010)
    36. Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism. (PubMed id 20384434)1, 4 Ruchat S.M....PAcrusse L. (Ann. Med. 2010)
    37. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. (PubMed id 20075150)1, 4 Talmud P.J....Humphries S.E. (BMJ 2010)
    38. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PubMed id 20161779)1, 4 Wen J....Hu R. (PLoS ONE 2010)
    39. Impact of single nucleotide polymorphisms and of clinical risk factors on newa89onset diabetes mellitus in HIVa89infected individuals. (PubMed id 20879858)1, 4 Rotger M....Tarr P.E. (Clin. Infect. Dis. 2010)
    40. Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. (PubMed id 19808892)1, 4 't Hart L.M....Fritsche A. (Diabetes 2010)
    41. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    42. A genome-wide association study of optic disc parameters. (PubMed id 20548946)1, 4 Ramdas W.D....van Duijn C.M. (PLoS Genet. 2010)
    43. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (Lancet 2010)
    44. Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. (PubMed id 19892838)1, 4 Tan J.T....Tai E.S. (J. Clin. Endocrinol. Metab. 2010)
    45. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    46. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (Rev Esp Cardiol 2010)
    47. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (Hum. Hered. 2010)
    48. The susceptibility CDKN2 locus may have a role on prognosis of melanoma patients. (PubMed id 20231302)1, 4 Casula M....Palmieri G. (Ann. Oncol. 2010)
    49. Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. (PubMed id 20395613)1, 4 Hashikata H....Koizumi A. ( a journal of cerebral circulation 2010)
    50. Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. (PubMed id 20858905)1, 4 Musunuru K....Mitchell B.D. (Circ Cardiovasc Genet 2010)
    51. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. (PubMed id 19002430)1, 4 Cho Y.M....Jang H.C. (Diabetologia 2009)
    52. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. (PubMed id 19578366)1, 4 Wrensch M....Wiencke J.K. (Nat. Genet. 2009)
    53. Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4 Jardin F....Tilly H. (Br. J. Haematol. 2009)
    54. Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. (PubMed id 19592620)1, 4 Zhao J....Grant S.F. (Diabetes 2009)
    55. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. (PubMed id 19139842)1, 4 Lin X....Mooser V. (Diabetologia 2009)
    56. Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. (PubMed id 19247372)1, 4 Miyake K....Kasuga M. (J. Hum. Genet. 2009)
    57. Genome-wide association study identifies five susceptibility loci for glioma. (PubMed id 19578367)1, 4 Shete S....Houlston R.S. (Nat. Genet. 2009)
    58. Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes. (PubMed id 20215779)1, 4 Ruchat S.M....PAcrusse L. (J Nutrigenet Nutrigenomics 2009)
    59. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. (PubMed id 19214202)1, 4 Schaefer A.S....Schreiber S. (PLoS Genet. 2009)
    60. Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. (PubMed id 19324937)1, 4 Brito E.C....Franks P.W. (Diabetes 2009)
    61. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. (PubMed id 19862325)1, 4 Hu C....Jia W. (PLoS ONE 2009)
    62. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    63. Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study. (PubMed id 19741166)1, 4 Kelliny C....Langenberg C. (Diabetes 2009)
    64. Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. (PubMed id 19741467)1, 4 Kang E.S....Kim Y.S. (Transplantation 2009)
    65. Underlying genetic models of inheritance in established type 2 diabetes associations. (PubMed id 19602701)1, 4 Salanti G....Ioannidis J.P. (Am. J. Epidemiol. 2009)
    66. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. (PubMed id 19225753)1, 4 Pulizzi N....Eriksson J.G. (Diabetologia 2009)
    67. New common variants affecting susceptibility to basal cell carcinoma. (PubMed id 19578363)1, 4 Stacey S.N....Stefansson K. (Nat. Genet. 2009)
    68. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. (PubMed id 19056611)1, 4 Timpson N.J....McCarthy M.I. (Diabetes 2009)
    69. Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism. (PubMed id 19258437)1, 4 van Hoek M....Roseboom T.J. (Diabetes 2009)
    70. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. (PubMed id 19502414)1, 4 StancA!kovA! A....Laakso M. (Diabetes 2009)
    71. ETV6-RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis. (PubMed id 19665068)1, 4 Emerenciano M....Pombo-de-Oliveira M.S. (Cancer Genet. Cytogenet. 2009)
    72. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)1, 4  ....Altshuler D. (Nat. Genet. 2009)
    73. Type 2 diabetes risk alleles are associated with reduced size at birth. (PubMed id 19228808)1, 4 Freathy R.M....Hattersley A.T. (Diabetes 2009)
    74. Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. (PubMed id 19279076)1, 4 Qi L....Hu F.B. (Am. J. Clin. Nutr. 2009)
    75. Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. (PubMed id 19033397)1, 4 Tabara Y....Makino H. (Diabetes 2009)
    76. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. (PubMed id 19166692)1, 4 van der Net J.B....Steyerberg E.W. (Am. J. Cardiol. 2009)
    77. The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. (PubMed id 19293724)1, 4 Wahlstrand B....Melander O. (J. Hypertens. 2009)
    78. Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas. (PubMed id 19383911)1, 4 Kuo K.T....Wang T.L. (Cancer Res. 2009)
    79. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. (PubMed id 19380854)1, 4 Cornelis M.C....Hu F.B. (Ann. Intern. Med. 2009)
    80. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4 Goode E.L....Sellers T.A. (amp 2009)
    81. Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. (PubMed id 19720844)1, 4 Schulze M.B....Joost H.G. (Diabetes Care 2009)
    82. Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. (PubMed id 19082521)1, 4 Ruchat S.M....PAcrusse L. (Acta Diabetol 2009)
    83. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. (PubMed id 19008344)1, 4 Rong R....Baier L.J. (Diabetes 2009)
    84. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    85. Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype. (PubMed id 19144660)1, 4 Akagi T....Koeffler H.P. (Haematologica 2009)
    86. The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity. (PubMed id 19258404)1, 4 Haupt A....HAoring H.U. (J. Clin. Endocrinol. Metab. 2009)
    87. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. (PubMed id 19401414)1, 4 Takeuchi F....Kato N. (Diabetes 2009)
    88. Genetic variants on chromosome 9p21 and ischemic stroke in Chinese. (PubMed id 19559344)1, 4 Hu W.L....Wang X.F. (Brain Res. Bull. 2009)
    89. Common type 2 diabetes risk gene variants associate with gestational diabetes. (PubMed id 18984664)1, 4 Lauenborg J....Hansen T. (J. Clin. Endocrinol. Metab. 2009)
    90. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
    91. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PubMed id 18372903)1, 4 Zeggini E....Altshuler D. (Nat. Genet. 2008)
    92. Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). (PubMed id 18437351)1, 4 Hertel J.K....lstad P.R. (Diabetologia 2008)
    93. Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study. (PubMed id 18925945)1, 4 Dehghan A....Witteman J.C. (BMC Med 2008)
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    267. Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia. (PubMed id 17074388)1 Ogawa M....Koike K. (Leuk. Res. 2007)
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    269. High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway. (PubMed id 17597576)1 Chen Y.H....Chuang L.Y. (Arch. Biochem. Biophys. 2007)
    270. Epigenetic events underlie the pathogenesis of sinonasal papillomas. (PubMed id 17673925)1 Stephen J.K....Worsham M.J. (Mod. Pathol. 2007)
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    272. Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene. (PubMed id 17316622)1 Hitomi T....Sakai T. (FEBS Lett. 2007)
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    309. Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. (PubMed id 11764089)9 Wolter M....Reifenberger G. (J. Neuropathol. Exp. Neurol. 2001)
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    355. Deletions of p15 and p16 in schistosomal bladder cancer correlate with transforming growth factor-alpha expression. (PubMed id 15589816)9 Swellam M....AbuGabel K.M. (Clin. Biochem. 2004)
    356. The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR. (PubMed id 12932666)9 Wong T.S....Yuen A.P. (Eur. J. Cancer 2003)
    357. Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. (PubMed id 11435325)9 Teofili L....Larocca L.M. (Blood 2001)
    358. Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. (PubMed id 11485924)9 BostrAPm J....Reifenberger G. (Am. J. Pathol. 2001)
    359. Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes. (PubMed id 10764143)9 Aoki E....Murate T. (Leukemia 2000)
    360. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. (PubMed id 10634644)9 Guo S.X....Hayashi Y. (Leuk. Res. 2000)
    361. Abnormalities of tumor suppressor genes P16 and P15 in primary maxillofacial squamous cell carcinomas. (PubMed id 10432931)9 Zhao Y....Xiao C. (Cancer Genet. Cytogenet. 1999)
    362. Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China. (PubMed id 9934853)9 Xing E.P....Yang C.S. (Carcinogenesis 1999)
    363. Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. (PubMed id 9554401)9 Heidenreich A....Srivastava S. (J. Urol. 1998)
    364. Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. (PubMed id 9537438)9 Iolascon A....Della Ragione F. (Hepatology 1998)
    365. Hypermethylation of p15/ink4b/MTS2 gene is differentially implicated among non-Hodgkin's lymphomas. (PubMed id 9639423)9 Martinez-Delgado B....Benitez J. (Leukemia 1998)
    366. Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas. (PubMed id 8855819)9 Tahara H....Arnold A. (J. Clin. Endocrinol. Metab. 1996)
    367. Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. (PubMed id 7994022)9 Hebert J....Sigaux F. (Blood 1994)
    368. p15Ink4b: dual function in myelopoiesis and inactivation in myeloid disease. (PubMed id 18029205)9 Rosu-Myles M. and Wolff L. (amp 2008)
    369. Promoter hypermethylation analysis in myelodysplastic syndromes: diagnostic &amp; prognostic implication. (PubMed id 18316853)9 Solomon P.R....Shanmugam G. (Indian J. Med. Res. 2008)
    370. Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. (PubMed id 15851765)9 Bueso-Ramos C....Garcia-Manero G. (J. Clin. Oncol. 2005)
    371. Establishment and partial characterization of five malignant glioma cell lines. (PubMed id 15875906)9 Zhang L....Naganuma H. (Neuropathology 2005)
    372. 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. (PubMed id 16010433)9 Matsuzaki Y....Sakai T. (Int. J. Oncol. 2005)
    373. [Expression of PTKs CDK4 and p15 in the middle ear cholesteatomatous epithelium]. (PubMed id 15620145)9 Sun W....Su J. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2004)
    374. Methylation profiling in multiple myeloma. (PubMed id 15109538)9 Chim C.S....Liang R. (Leuk. Res. 2004)
    375. Cell cycle regulators in bladder cancer: relationship to schistosomiasis. (PubMed id 15590562)9 Eissa S....El-Ahmady O. (IUBMB Life 2004)
    376. Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias. (PubMed id 14513284)9 Chim C.S....Kwong Y.L. (Ann. Hematol. 2003)
    377. Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. (PubMed id 14681685)9 Wolff L....Perella C. (Oncogene 2003)
    378. Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis. (PubMed id 12750706)9 Teofili L....Larocca L.M. (Leukemia 2003)
    379. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. (PubMed id 12351408)9 Daskalakis M....LA1bbert M. (Blood 2002)
    380. Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation. (PubMed id 11593429)9 Schmidt M....Wolff L. (Oncogene 2001)
    381. KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients. (PubMed id 11532526)9 Dodge J.E....List A.F. (Leuk. Res. 2001)
    382. Analysis of cyclin-dependent kinase inhibitor expression and methylation patterns in human prostate cancers. (PubMed id 10797499)9 Nguyen T.T....Jones P.A. (Prostate 2000)
    383. Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia. (PubMed id 10778944)9 Omura-Minamisawa M....Yu A.L. (Clin. Cancer Res. 2000)
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    386. Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. (PubMed id 12894891)9 Yonghao T....Yandell D.W. (Chin. Med. Sci. J. 1999)
    387. Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma. (PubMed id 9536218)9 Wagner S.N....Goos M. (Br. J. Dermatol. 1998)
    388. Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb. (PubMed id 9697882)9 GrA...Ralfkiaer E. (Leukemia 1998)
    389. Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages. (PubMed id 9570245)9 Wu M.S....Lin J.T. (J. Gastroenterol. Hepatol. 1998)
    390. Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma. (PubMed id 9616165)9 Elenitoba-Johnson K.S....Raffeld M. (Blood 1998)
    391. Absence of p15INK4B and p16INK4A gene alterations in primary cervical carcinoma tissues and cell lines with human papillomavirus infection. (PubMed id 9698478)9 Kim J.W....Kim I.K. (Gynecol. Oncol. 1998)
    392. Association of CDKN2A(p16)/CDKN2B(p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma. (PubMed id 9624535)9 Hamada K....Yokota J. (amp 1998)
    393. Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation. (PubMed id 9792305)9 Wong I.H....Huang D.P. (Br. J. Haematol. 1998)
    394. P53, p15INK4B, p16INK4A and p57KIP2 mutations during the progression of chronic myeloid leukemia. (PubMed id 10069444)9 GA1ran S....YalAsin A. (Haematologia (Budap) 1998)
    395. Infrequent mutations and no methylation of CDKN2A (P16/MTS1) and CDKN2B (p15/MTS2) in hepatocellular carcinoma in Taiwan. (PubMed id 9893670)9 Lin Y.W....Sheu J.C. (Eur. J. Cancer 1998)
    396. Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours. (PubMed id 9000591)9 Schmidt E.E....Collins V.P. (Br. J. Cancer 1997)
    397. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. (PubMed id 9041182)9 Herman J.G....Baylin S.B. (Cancer Res. 1997)
    398. Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma. (PubMed id 9012694)9 Tasaka T....Koeffler H.P. (Br. J. Haematol. 1997)
    399. Establishment of a novel human B-cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes. (PubMed id 9600110)9 Nagai M....Takahara J. (Hematol Oncol 1997)
    400. Alterations in the tumor suppressor genes p53, RB, p16/MTS1, and p15/MTS2 in human pancreatic cancer and hepatoma cell lines. (PubMed id 9058294)9 Kaino M. (J. Gastroenterol. 1997)
    401. Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. (PubMed id 9269757)9 Uchida T....Murate T. (Blood 1997)
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    403. The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes. (PubMed id 8873383)9 Stadler W.M. and Olopade O.I. (Urol. Res. 1996)
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    406. Growth suppression of esophageal cancer cells by p16INK4 and p15INK4B in vitro. (PubMed id 9166536)9 Zhou X....Meltzer S.J. (Cancer J Sci Am 1996)
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    408. Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers. (PubMed id 8631583)9 Rusin M.R....Harris C.C. (Int. J. Cancer 1996)
    409. A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations. (PubMed id 8878451)9 Zhang S....Kumanishi T. (Jpn. J. Cancer Res. 1996)
    410. p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia. (PubMed id 7780130)9 Rasool O....Einhorn S. (Blood 1995)
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    412. Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias. (PubMed id 7577621)9 Nakamaki T....Tsuruoka N. (Br. J. Haematol. 1995)
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    415. Codeletion of p15 and p16 in primary malignant mesothelioma. (PubMed id 7630635)9 Xio S....Fletcher J.A. (Oncogene 1995)
    416. Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines. (PubMed id 7577470)9 Southgate J....Selby P. (Br. J. Cancer 1995)
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    419. The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells. (PubMed id 14976051)9 Schmidt M....Wolff L. (Blood 2004)
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    421. Translation of p15.5INK4B, an N-terminally extended and fully active form of p15INK4B, is initiated from an upstream GUG codon. (PubMed id 10763830)9 Fuxe J....Pettersson R.F. (Oncogene 2000)
    422. Mutations of p16 and p15 tumor suppressor genes and replication errors contribute independently to the pathogenesis of sporadic malignant melanoma. (PubMed id 9617435)9 Matsumura Y....Takebe H. (Arch. Dermatol. Res. 1998)
    423. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. (PubMed id 9639410)9 Drexler H.G. (Leukemia 1998)
    424. Deletion of P15 (MTS2) in head and neck squamous cell carcinomas. (PubMed id 9698532)9 Roesler J.M....Wang M.B. (J. Surg. Res. 1998)
    425. Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma. (PubMed id 9168184)9 Platz A....Ringborg U. (J. Natl. Cancer Inst. 1997)
    426. Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. (PubMed id 9164185)9 Yamada Y....Tomonaga M. (J. Clin. Oncol. 1997)
    427. Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells. (PubMed id 9001419)9 Schwaller J....Tobler A. (Leukemia 1997)
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    429. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. (PubMed id 8630377)9 Cayuela J.M....Sigaux F. (Blood 1996)
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    441. Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas. (PubMed id 12874790)9 Kawakami T....Okada Y. (amp 2003)
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    446. Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion. (PubMed id 9044834)9 Gray-Bablin J....Keyomarsi K. (Cancer Res. 1997)
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    489. Differential gene methylation in undifferentiated nasopharyngeal carcinoma. (PubMed id 12632081)9 Wong T.S....Yuen A.P. (Int. J. Oncol. 2003)
    490. Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance. (PubMed id 12899712)9 Chim C.S....Kwong Y.L. (Br. J. Haematol. 2003)
    491. Aberrant promoter CpG methylation as a molecular marker for disease monitoring in natural killer cell lymphomas. (PubMed id 12823347)9 Siu L.L....Kwong Y.L. (Br. J. Haematol. 2003)
    492. Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN. (PubMed id 14519639)9 BAocklund L.M....Collins V.P. (Clin. Cancer Res. 2003)
    493. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. (PubMed id 11839665)9 Chan M.W....To K.F. (Clin. Cancer Res. 2002)
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    495. Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. (PubMed id 11167795)9 Tien H.F....Shen M.C. (Br. J. Haematol. 2001)
    496. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. (PubMed id 11413518)9 Leung W.K....Sung J.J. (Cancer 2001)
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    498. Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation. (PubMed id 10997979)9 Furukawa Y....Matsuda M. (Br. J. Haematol. 2000)
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    500. Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway. (PubMed id 10454538)9 Warner B.J....MassaguAc J. (Mol. Cell. Biol. 1999)
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    502. Deletion of p16INK4A/CDKN2 and p15INK4B in human somatic cell hybrids and hybrid-derived tumors. (PubMed id 9950215)9 Kuerbitz S.J....Graff J.R. (amp 1999)
    503. The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity. (PubMed id 10066746)9 Sun J....Sebti S.M. (J. Biol. Chem. 1999)
    504. The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. (PubMed id 10585406)9 Hu P.P....Wang X.F. (J. Biol. Chem. 1999)
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    506. Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-beta-induced cell cycle arrest of gastric carcinoma cells. (PubMed id 10376964)9 Kang S.H....Kim S.J. (Br. J. Cancer 1999)
    507. Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins. (PubMed id 10362250)9 Sangfelt O....GrandAcr D. (Oncogene 1999)
    508. Structural and functional analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in neuroblastoma. (PubMed id 9432125)9 Iolascon A....Ragione F.D. (Pediatr. Res. 1998)
    509. Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma. (PubMed id 9591637)9 Dreyling M.H....Olopade O.I. (amp 1998)
    510. The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. (PubMed id 9466670)9 Prins J.B....Versnel M.A. (Int. J. Cancer 1998)
    511. Differential myeloma cell responsiveness to interferon-alpha correlates with differential induction of p19(INK4d) and cyclin D2 expression. (PubMed id 9565604)9 Arora T. and Jelinek D.F. (J. Biol. Chem. 1998)
    512. Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds. (PubMed id 9416844)9 Flores J.F....Fountain J.W. (Oncogene 1997)
    513. The commonly deleted region at 9p21-22 in lymphoblastic leukemias spans at least 400 kb and includes p16 but not p15 or the IFN gene cluster. (PubMed id 9009086)9 Aguiar R.C....Cross N.C. (Leukemia 1997)
    514. De novo methylation of tumour suppressor genes CDKN2A and CDKN2B is a rare finding in B-cell chronic lymphocytic leukaemia. (PubMed id 9375748)9 Martel V....Jonveaux P. (Br. J. Haematol. 1997)
    515. Comparative detection and quantitation of human CDK inhibitor mRNA expression of p15INK4B, p16INK4A, p16beta, p18INK4C, p19INK4D, p21WAF1, p27KIP1 and p57KIP2 by RT-PCR using a polycompetitive internal standard. (PubMed id 9432039)9 Schwaller J....Tobler A. (Br. J. Haematol. 1997)
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    517. Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. (PubMed id 9393981)9 Kovar H....Gadner H. (Oncogene 1997)
    518. Absence of p18 mutations or deletions in lymphoid malignancies. (PubMed id 8637248)9 Otsuki T....Raffeld M. (Leukemia 1996)
    519. Expression of CDK inhibitor genes in immortalized and carcinoma derived breast cell lines. (PubMed id 8712723)9 Zhou J.N. and Linder S. (Anticancer Res. 1996)
    520. Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors. (PubMed id 8621248)9 Sato K....Ohgaki H. (Int. J. Cancer 1996)
    521. Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. (PubMed id 7478613)9 Nakagawa K....Kelley M.J. (Oncogene 1995)
    522. Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. (PubMed id 7882348)9 Otsuki T....Raffeld M. (Cancer Res. 1995)
    523. Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides. (PubMed id 19759554)9 Salgado R....Espinet B. (J. Invest. Dermatol. 2010)
    524. Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. (PubMed id 20140953)9 Conway C....Newton-Bishop J.A. (amp 2010)
    525. Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia. (PubMed id 20237504)9 Deneberg S....Lehmann S. (Leukemia 2010)
    526. Spectral karyotypic and comparative genomic analysis of the endocrine pancreatic tumor cell line BON-1. (PubMed id 19887762)9 Lopez J.R....Speel E.J. (Neuroendocrinology 2010)
    527. Tocotrienols inhibited growth and induced apoptosis in human HeLa cells through the cell cycle signaling pathway. (PubMed id 20150225)9 Wu S.J. and Ng L.T. (Integr Cancer Ther 2010)
    528. Epigenetic changes in therapy-related MDS/AML. (PubMed id 19874806)9 Voso M.T....Leone G. (Chem. Biol. Interact. 2010)
    529. CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus. (PubMed id 20051228)9 Rodriguez C....Piette J. (Biochem. Biophys. Res. Commun. 2010)
    530. Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma. (PubMed id 20019193)9 Sato H....Yoshino T. (Am. J. Pathol. 2010)
    531. Genome-wide high-resolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array. (PubMed id 19603524)9 Mantripragada K.K....Upadhyaya M. (amp 2009)
    532. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (PubMed id 19208363)9 Trobridge P....Grady W.M. (Gastroenterology 2009)
    533. High-resolution analysis of aberrant regions in autosomal chromosomes in human leukemia THP-1 cell line. (PubMed id 19635138)9 Adati N....Kojima T. (BMC Res Notes 2009)
    534. Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants. (PubMed id 19888323)9 Folkersen L....Eriksson P. (PLoS ONE 2009)
    535. Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis. (PubMed id 19056458)9 Liou S.F....Yeh J.L. (Toxicology 2009)
    536. Expression of p18(INK4C) is down-regulated in human pituitary adenomas. (PubMed id 19401813)9 Hossain M.G....Yoshimoto K. (Endocr. Pathol. 2009)
    537. DNA hypermethylation profiles in squamous cell carcinoma of the vulva. (PubMed id 19047905)9 Stephen J.K....Worsham M.J. (Int. J. Gynecol. Pathol. 2009)
    538. Accumulation of aberrant CpG hypermethylation by Helicobacter pylori infection promotes development and progression of gastric MALT lymphoma. (PubMed id 19639175)9 Kondo T....Yoshino T. (Int. J. Oncol. 2009)
    539. Varying etiologies lead to different molecular changes in Australian and South African hepatocellular carcinomas. (PubMed id 19787262)9 Herath N.I....MacDonald G.A. (Int. J. Oncol. 2009)
    540. Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma. (PubMed id 19060847)9 Sinn D.H....Kim K.M. (Mod. Pathol. 2009)
    541. The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation. (PubMed id 18923142)9 Cheng F....Zagon I.S. (Mol. Biol. Cell 2009)
    542. Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. (PubMed id 18539616)9 Amara K....Korbi S. (Ann. Oncol. 2008)
    543. Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. (PubMed id 17977648)9 Singh A.P....Batra S.K. (Cancer Lett. 2008)
    544. Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma. (PubMed id 18712977)9 Alhebshi H.M....Mabruk M.J. (Asian Pac. J. Cancer Prev. 2008)
    545. Reprimo as a potential biomarker for early detection in gastric cancer. (PubMed id 18829507)9 Bernal C....Corvalan A.H. (Clin. Cancer Res. 2008)
    546. Losses of 3p14 and 9p21 as shown by fluorescence in situ hybridization are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis. (PubMed id 18163473)9 Schwarz S....Brockhoff G. (Cytometry A 2008)
    547. Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma. (PubMed id 18310086)9 Christensen B.C....Kelsey K.T. (Carcinogenesis 2008)
    548. A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. (PubMed id 18413836)9 Klisovic R.B....Marcucci G. (Clin. Cancer Res. 2008)
    549. Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. (PubMed id 18264082)9 Vivekanandan P. and Torbenson M. (Mod. Pathol. 2008)
    550. Circulating DNA in the blood of gastric cancer patients. (PubMed id 18837952)9 Kolesnikova E.V....Rykova E.Y. (Ann. N. Y. Acad. Sci. 2008)
    551. Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. (PubMed id 18241037)9 Chen J....Fan J.B. (Int. J. Cancer 2008)
    552. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. (PubMed id 18523155)9 Kroeger H....Issa J.P. (Blood 2008)
    553. Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays. (PubMed id 18519675)9 Nancarrow D.J....Whiteman D.C. (Cancer Res. 2008)
    554. Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. (PubMed id 18938072)9 RamA-rez N....GarcA-a-Foncillas J. (Eur. J. Cancer 2008)
    555. Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs). (PubMed id 18438954)9 Haller F....FA1zesi L. (J. Pathol. 2008)
    556. [Detection of p15 gene methylation or deletion status in different malignant cell lines by using hemi-nested methylation specific polymerase chain reaction]. (PubMed id 17493352)9 Lin F.A....Fan L.P. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007)
    557. DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. (PubMed id 17549390)9 Oh B.K....Park Y.N. (Int. J. Mol. Med. 2007)
    558. Characterization of genetic alteration patterns in human esophageal squamous cell carcinoma using selected microsatellite markers spanning multiple loci. (PubMed id 17390007)9 Cai Y.C....Yang C.S. (Int. J. Oncol. 2007)
    559. Modeling INK4/ARF tumor suppression in the mouse. (PubMed id 17311533)9 Berger J.H. and Bardeesy N. (Curr. Mol. Med. 2007)
    560. Reduced XPC messenger RNA level may predict a poor outcome of patients with nonsmall cell lung cancer. (PubMed id 17508409)9 Wu Y.H....Lee H. (Cancer 2007)
    561. Quantitative high-resolution CpG island mapping with Pyrosequencing reveals disease-specific methylation patterns of the CDKN2B gene in myelodysplastic syndrome and myeloid leukemia. (PubMed id 17095538)9 Brakensiek K....Lehmann U. (Clin. Chem. 2007)
    562. [Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes]. (PubMed id 17369979)9 Zavala G L....CorvalA!n R A. (Rev Med Chil 2007)
    563. Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome. (PubMed id 17350682)9 BogdanoviA8 G....PopoviA8 S. (Leuk. Res. 2007)
    564. DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation. (PubMed id 17577921)9 Hopfer O....Hofmann W.K. (Exp. Hematol. 2007)
    565. Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. (PubMed id 17784872)9 Yamaguchi T....Sakai T. (Cancer Sci. 2007)
    566. High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. (PubMed id 17997817)9 Klein-Scory S....Schwarte-Waldhoff I. (BMC Cancer 2007)
    567. HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese. (PubMed id 17454594)9 Au W.Y....Liang R. (amp 2007)
    568. Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses. (PubMed id 17206475)9 MA1hlisch J....FrA1hwald M.C. (J. Neurooncol. 2007)
    569. Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. (PubMed id 17376510)9 Milne A.N....Weterman M.A. (Hum. Pathol. 2007)
    570. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. (PubMed id 17230231)9 Jost E....Galm O. (Leukemia 2007)
    571. CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. (PubMed id 16707594)9 Chang M.S....Fukayama M. (Clin. Cancer Res. 2006)
    572. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. (PubMed id 16537562)9 Peng D.F....Hirohashi S. (Carcinogenesis 2006)
    573. The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951. (PubMed id 16818274)9 Mirebeau D....CavAc H. (Haematologica 2006)
    574. Inactivation of CDKN2A, CDKN2B and MTAP in childhood B-lineage acute lymphobastic leukemia. (PubMed id 16818264)9 Beverloo H.B. (Haematologica 2006)
    575. Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas. (PubMed id 16989737)9 Gray S.E....Mabruk M. (J. Cell. Mol. Med. 2006)
    576. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. (PubMed id 16928264)9 Yang H.J....Ngan H.Y. (BMC Cancer 2006)
    577. Glucocorticoid up-regulates transforming growth factor-beta (TGF-beta) type II receptor and enhances TGF-beta signaling in human prostate cancer PC-3 cells. (PubMed id 16887915)9 Li Z....Lu J. (Endocrinology 2006)
    578. Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. (PubMed id 16081515)9 Hellerbrand C....Bosserhoff A.K. (Carcinogenesis 2006)
    579. The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (PubMed id 17043023)9 Sarasquete M.E....San Miguel J.F. (Haematologica 2006)
    580. Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma. (PubMed id 16616114)9 Michalowski M.B....Plantaz D. (Cancer Genet. Cytogenet. 2006)
    581. A FoxO-Smad synexpression group in human keratinocytes. (PubMed id 16908841)9 Gomis R.R....MassaguAc J. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    582. Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing. (PubMed id 16185764)9 Nagasawa T....Wasik M.A. (Leuk. Res. 2006)
    583. Molecular and cytogenetic subgroups of oropharyngeal squamous cell carcinoma. (PubMed id 17121883)9 Perrone F....Pilotti S. (Clin. Cancer Res. 2006)
    584. Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia. (PubMed id 16039715)9 Yang Y....Koeffler H.P. (Leuk. Res. 2006)
    585. Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. (PubMed id 16369045)9 Cheng Y.W....Barany F. (Genome Res. 2006)
    586. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. (PubMed id 16505103)9 Mantena S.K....Katiyar S.K. (Mol. Cancer Ther. 2006)
    587. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. (PubMed id 16140969)9 Burdette J.E....Woodruff T.K. (Cancer Res. 2005)
    588. Probing the chromosome 9p21 region susceptible to DNA double-strand breaks in human cells in vivo by restriction enzyme transfer. (PubMed id 16007206)9 Sato M....Kohno T. (Oncogene 2005)
    589. In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages. (PubMed id 15738662)9 LAPwenheim H....Knipper M. (Tissue Eng. 2005)
    590. Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells. (PubMed id 15839997)9 Wang L....Colbert M.C. (amp 2005)
    591. Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia. (PubMed id 15755503)9 Kumagai T....Koeffler H.P. (Leuk. Res. 2005)
    592. Absence of p16 and p27 gene rearrangements and mutations in de novo myelodysplastic syndromes. (PubMed id 16104874)9 Papageorgiou S.G....Economopoulos T. (Eur. J. Haematol. 2005)
    593. Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. (PubMed id 15753386)9 Panopoulou E....Fotsis T. (Cancer Res. 2005)
    594. Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells. (PubMed id 16322252)9 Hu X....Manni A. (Cancer Res. 2005)
    595. Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival. (PubMed id 15837753)9 GrafstrAPm E....Platz A. (Clin. Cancer Res. 2005)
    596. Characterization of Sno expression in malignant melanoma. (PubMed id 15809735)9 Poser I....Bosserhoff A.K. (Int. J. Oncol. 2005)
    597. Clinical experience with decitabine in North American patients with myelodysplastic syndrome. (PubMed id 16273408)9 Yee K.W....Giles F.J. (Ann. Hematol. 2005)
    598. Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas. (PubMed id 15892004)9 Liu Y....Ng H.K. (Hum. Pathol. 2005)
    599. Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia. (PubMed id 15737564)9 Tsellou E....Petridou E. (Eur. J. Cancer 2005)
    600. Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. (PubMed id 16192589)9 Roman-Gomez J....Torres A. (J. Clin. Oncol. 2005)
    601. Progressive methylation during the serrated neoplasia pathway of the colorectum. (PubMed id 15389252)9 Dong S.M....Kim K.M. (Mod. Pathol. 2005)
    602. Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPA): Its usefulness as an adjunctive diagnostic tool for melanocytic tumors. (PubMed id 16054806)9 Takata M....Saida T. (J. Dermatol. Sci. 2005)
    603. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer. (PubMed id 15942635)9 Leung W.K....Sung J.J. (Br. J. Cancer 2005)
    604. Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. (PubMed id 15164098)9 Inoue R....Wade-Martins R. (Gene Ther. 2004)
    605. Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK. (PubMed id 14971655)9 Ceryak S....Patierno S.R. (Mol. Cell. Biochem. 2004)
    606. Role for BRG1 in cell cycle control and tumor suppression. (PubMed id 14673169)9 Hendricks K.B....Lees E. (Mol. Cell. Biol. 2004)
    607. Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. (PubMed id 14688019)9 Lindsey J.C....Clifford S.C. (Carcinogenesis 2004)
    608. DNA methylation changes in multiple myeloma. (PubMed id 15318245)9 Galm O....Osieka R. (Leukemia 2004)
    609. Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21-23 in the biology of favourable stage 4 tumours. (PubMed id 15305192)9 Mora J....Gerald W.L. (Br. J. Cancer 2004)
    610. Systematic multiplex polymerase chain reaction and reverse transcription-polymerase chain reaction analyses of changes in copy number and expression of proto-oncogenes and tumor suppressor genes in cancer tissues and cell lines. (PubMed id 15490458)9 Yamamoto M....Yamamoto F. (Electrophoresis 2004)
    611. Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas. (PubMed id 15531468)9 Gallardo F....Servitje O. (Haematologica 2004)
    612. Molecular pathogenesis of meningiomas. (PubMed id 15674477)9 Perry A....Reifenberger G. (J. Neurooncol. 2004)
    613. DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. (PubMed id 15197802)9 Seidl S....ZAPchbauer-MA1ller S. (Cancer 2004)
    614. Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. (PubMed id 14647420)9 Han S.U....Kim S.J. (Oncogene 2004)
    615. High-throughput method for detecting DNA methylation. (PubMed id 15262448)9 Hou P....Lu Z. (J. Biochem. Biophys. Methods 2004)
    616. High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population. (PubMed id 14732922)9 Hu N....Goldstein A.M. (amp 2004)
    617. Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. (PubMed id 15477587)9 Scandura J.M....Nimer S.D. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    618. Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma. (PubMed id 15221997)9 Chang H.W....Yuen A.P. (Cancer 2004)
    619. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (PubMed id 15367334)9 Yu J....Zhu J. (BMC Cancer 2004)
    620. CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. (PubMed id 15154012)9 GutiAcrrez M.I....Bhatia K. (Mod. Pathol. 2004)
    621. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. (PubMed id 15526363)9 Xu X.L....Zhu J.D. (World J. Gastroenterol. 2004)
    622. Hypermethylation of CpG islands in primary and metastatic human prostate cancer. (PubMed id 15026333)9 Yegnasubramanian S....Nelson W.G. (Cancer Res. 2004)
    623. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. (PubMed id 15198948)9 Roman-Gomez J....Torres A. (Blood 2004)
    624. p14ARF, p15INK4b and p16INK4a methylation status in chronic myelogenous leukemia. (PubMed id 15370242)9 Kusy S....Roche J. (amp 2004)
    625. Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma. (PubMed id 15073117)9 Wong T.S....Yuen A.P. (Clin. Cancer Res. 2004)
    626. Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. (PubMed id 15386372)9 Bai A.H....Leung W.K. (Int. J. Cancer 2004)
    627. Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia. (PubMed id 15495254)9 Ekmekci C.G....Bhatia K. (Am. J. Hematol. 2004)
    628. Cell cycle regulators at the ocular surface. (PubMed id 15106924)9 Zieske J.D....Guo X. (Exp. Eye Res. 2004)
    629. NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner. (PubMed id 15588951)9 Slupianek A. and Skorski T. (Exp. Hematol. 2004)
    630. Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup. (PubMed id 12970785)9 Gutierrez M.I....Bhatia K. (Leukemia 2003)
    631. Epigenetic targets in hematopoietic malignancies. (PubMed id 14528273)9 Claus R. and LA1bbert M. (Oncogene 2003)
    632. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. (PubMed id 12554760)9 Yao M.W....Maas R.L. (Mol. Endocrinol. 2003)
    633. Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia. (PubMed id 12888905)9 Uehara E....Koeffler H.P. (Int. J. Oncol. 2003)
    634. Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells. (PubMed id 12559313)9 Kawakami T....Okada Y. (Urology 2003)
    635. Clinical and genetic characteristics of Japanese Burkitt lymphomas with or without leukemic presentation. (PubMed id 12841388)9 Namiki T....Kaneko Y. (Int. J. Hematol. 2003)
    636. Detection of cell-cycle regulators in failed arteriovenous fistulas for haemodialysis. (PubMed id 12637654)9 de Graaf R....Tordoir J.H. (Nephrol. Dial. Transplant. 2003)
    637. Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia. (PubMed id 12548613)9 Garcia-Manero G....Issa J.P. (Cancer 2003)
    638. Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. (PubMed id 12845670)9 Edamoto Y....Ohgaki H. (Int. J. Cancer 2003)
    639. Deregulation of the RB pathway in human testicular germ cell tumours. (PubMed id 12754735)9 Bartkova J....Bartek J. (J. Pathol. 2003)
    640. Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. (PubMed id 12875987)9 Behrmann I....Bosserhoff A.K. (Am. J. Pathol. 2003)
    641. Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors. (PubMed id 12963998)9 Obana K....Hayashi Y. (Int. J. Oncol. 2003)
    642. Characterization of gastrin-induced cytostatic effect on cell proliferation in experimental malignant gliomas. (PubMed id 12657185)9 Lefranc F....Kiss R. (Neurosurgery 2003)
    643. Mutation analysis of candidate genes in melanoma-prone families: evidence of different pathogenetic mechanisms at chromosome 9P21. (PubMed id 14646620)9 Casula M....Palmieri G. (Melanoma Res. 2003)
    644. [Effects of hexamethylene bisacetamide on cell cycle and expression of its regulatory proteins in HL-60 cells]. (PubMed id 14575541)9 Wang Q.H....Liu Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2003)
    645. TGF beta1 induces multiple independent signals to regulate human trophoblastic differentiation: mechanistic insights. (PubMed id 12943995)9 Rama S....Rao A.J. (Mol. Cell. Endocrinol. 2003)
    646. Distinct methylation profiles of glioma subtypes. (PubMed id 12794756)9 Uhlmann K....Laird P.W. (Int. J. Cancer 2003)
    647. CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia. (PubMed id 12661005)9 Bertin R....CavAc H. (amp 2003)
    648. [Effects of two LMP1 variants on resistance of CNE1 cell strain to TGF-beta1]. (PubMed id 14693046)9 Huang H. and Huang P.C. (Ai Zheng 2003)
    649. Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions. (PubMed id 12959350)9 Lossos I.S. and Levy R. (Semin. Cancer Biol. 2003)
    650. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. (PubMed id 12937151)9 Yang B....Clark D.P. (Am. J. Pathol. 2003)
    651. Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. (PubMed id 12565816)9 Gartel A.L. and Shchors K. (Exp. Cell Res. 2003)
    652. [Homozygous deletion of p16 and p15 genes in laryngeal squamous cell carcinoma]. (PubMed id 11836682)9 Li F....Sun K. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002)
    653. Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study. (PubMed id 11853794)9 Hofmann W.K....Ottmann O.G. (Lancet 2002)
    654. Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation. (PubMed id 11960918)9 Smeds J....Kumar R. (Carcinogenesis 2002)
    655. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. (PubMed id 12448005)9 To K.F....Sung J.J. (Int. J. Cancer 2002)
    656. Cyclin D-dependent kinases, INK4 inhibitors and cancer. (PubMed id 11960696)9 Ortega S....Barbacid M. (Biochim. Biophys. Acta 2002)
    657. [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]. (PubMed id 12667347)9 Tong H. and Lin M. (Zhonghua Xue Ye Xue Za Zhi 2002)
    658. Cell cycle control genes and hematopoietic cell differentiation. (PubMed id 11999551)9 Furukawa Y. (amp 2002)
    659. Hypermethylation of the p15(INK4B) gene in acute leukemia and myelodysplastic syndromes. (PubMed id 12150726)9 Chen H. and Wu S. (Chin. Med. J. 2002)
    660. Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. (PubMed id 11840272)9 Kulkarni M.S....Williams M.E. (Leukemia 2002)
    661. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. (PubMed id 12143052)9 Roncalli M....Coggi G. (Hepatology 2002)
    662. Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. (PubMed id 11945174)9 Yoon G....Lee J.H. (Biochem. J. 2002)
    663. Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms. (PubMed id 12460470)9 Sugimoto K.J....Oshimi K. (Jpn. J. Cancer Res. 2002)
    664. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. (PubMed id 12433278)9 Yu J....Zhu J. (BMC Cancer 2002)
    665. Hypermethylation of gene promoters in hematological neoplasia. (PubMed id 12469326)9 Chim C.S....Kwong Y.L. (Hematol Oncol 2002)
    666. [Inhibitory effect on proliferation of KG1a cell line by methyltransferase inhibitors]. (PubMed id 12513759)9 Chen H....Wang J.Z. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2002)
    667. Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. (PubMed id 11325847)9 Matsushima-Nishiu M....Nakamura Y. (Cancer Res. 2001)
    668. Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors. (PubMed id 11487055)9 Dong S.M....Ng H.K. (J. Neuropathol. Exp. Neurol. 2001)
    669. Molecular genetic abnormalities in premalignant lung lesions: biological and clinical implications. (PubMed id 11432708)9 Niklinski J....Pluygers E. (Eur. J. Cancer Prev. 2001)
    670. Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas. (PubMed id 11642545)9 Nam D.H....Kim J.H. (amp 2001)
    671. p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells. (PubMed id 11795482)9 Draus J.M....McMasters K.M. (amp 2001)
    672. One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus. (PubMed id 11704876)9 Gilley J. and Fried M. (Oncogene 2001)
    673. A long distance-PCR derived FISH probe detects a deletion between p15 and p16 in CML and T-ALL patients. (PubMed id 11351270)9 Bleichert A....von Eggeling F. (Int. J. Mol. Med. 2001)
    674. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. (PubMed id 11423975)9 Dauphinot L....Delattre O. (Oncogene 2001)
    675. [Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of medulloblastoma--results of a genomewide methylation scan]. (PubMed id 11528554)9 FrA1hwald M.C....Plass C. (Klin Padiatr 2001)
    676. Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development. (PubMed id 11602627)9 Sakashita K....Kubota T. (J. Clin. Invest. 2001)
    677. Repression of human reduced folate carrier gene expression by wild type p53. (PubMed id 11106643)9 Ding B.C....Matherly L.H. (J. Biol. Chem. 2001)
    678. [Molecular mechanisms controlling the cell cycle: fundamental aspects and implications for oncology]. (PubMed id 11355576)9 Viallard J.F....Reiffers J. (Cancer Radiother 2001)
    679. A PCR-based method for studying DNA methylation. (PubMed id 12843452)9 Ariel M. (Methods Mol. Biol. 2001)
    680. Bladder cancer. I. Molecular and genetic basis of carcinogenesis. (PubMed id 11464028)9 Brandau S. and BAPhle A. (Eur. Urol. 2001)
    681. Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia. (PubMed id 11243384)9 Uchida T....Saito H. (Leukemia 2001)
    682. Primary malignant lymphoma of the brain: analysis of MMAC1 (PTEN) tumor suppressor gene. (PubMed id 11908870)9 Ding X....Kumanishi T. (Brain Tumor Pathol 2001)
    683. A gene hypermethylation profile of human cancer. (PubMed id 11309270)9 Esteller M....Herman J.G. (Cancer Res. 2001)
    684. A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2. (PubMed id 11581254)9 Prall O.W....Sutherland R.L. (J. Biol. Chem. 2001)
    685. Increased expression of p27Kip1 arrests neuroblastoma cell growth. (PubMed id 11464914)9 Matsuo T....Thiele C.J. (Med. Pediatr. Oncol. 2001)
    686. Atherosclerosis and cancer: common molecular pathways of disease development and progression. (PubMed id 11795276)9 Ross J.S....Ginsburg G.S. (Ann. N. Y. Acad. Sci. 2001)
    687. H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism. (PubMed id 10698496)9 Delgado M.D....LeA^n J. (Oncogene 2000)
    688. Clonality analysis by methylation-specific PCR for the human androgen-receptor gene (HUMARA-MSP). (PubMed id 10637497)9 Uchida T....Kinoshita T. (Leukemia 2000)
    689. Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line. (PubMed id 10721718)9 Pacheco T.R....Maxwell I.H. (Gene 2000)
    690. Malignant hematopoietic cell lines: in vitro models for the study of myelodysplastic syndromes. (PubMed id 10654445)9 Drexler H.G. (Leuk. Res. 2000)
    691. Anti-sense oligonucleotide of p21(waf1/cip1) prevents interleukin 4-mediated elevation of p27(kip1) in low grade astrocytoma cells. (PubMed id 10698511)9 Liu J....Barna B.P. (Oncogene 2000)
    692. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. (PubMed id 11126361)9 Schmid M....Carson D.A. (Oncogene 2000)
    693. Cyclin A down-regulation in TGFbeta1-arrested follicular lymphoma cells. (PubMed id 11082295)9 Djaborkhel R....MA1ller J. (Exp. Cell Res. 2000)
    694. Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells. (PubMed id 10896783)9 Hsu S.L....Chang C.D. (Exp. Cell Res. 2000)
    695. High frequency of loss of heterozygosity on chromosome region 9p21-p22 but lack of p16INK4a/p19ARF mutations in greek patients with basal cell carcinoma of the skin. (PubMed id 10998150)9 Saridaki Z....Spandidos D.A. (J. Invest. Dermatol. 2000)
    696. Dissociation of bone morphogenetic protein-mediated growth arrest and apoptosis of mouse B cells by HPV-16 E6/E7. (PubMed id 10854068)9 Yamato K....Nishihara T. (Exp. Cell Res. 2000)
    697. Aneuploidy of chromosome 9 and the tumor suppressor genes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally advanced prostate cancer. (PubMed id 11025389)9 Heidenreich B....Sesterhenn I.A. (Eur. Urol. 2000)
    698. [Mechanism of tumorigenesis caused by tumor suppressor gene]. (PubMed id 10879046)9 Hayashi Y. (Nippon Rinsho 2000)
    699. Analysis of G(1)/S checkpoint regulators in metastatic melanoma. (PubMed id 10862049)9 Sauroja I....PyrhAPnen S. (amp 2000)
    700. Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. (PubMed id 10884382)9 Jin Y.H....Lee S.K. (J. Biol. Chem. 2000)
    701. Stem cell factor inhibits erythroid differentiation by modulating the activity of G1-cyclin-dependent kinase complexes: a role for p27 in erythroid differentiation coupled G1 arrest. (PubMed id 10845428)9 Tamir A....Ben-David Y. (amp 2000)
    702. Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas. (PubMed id 10773403)9 Zhuang S.M....SAPderkvist P. (Cancer Lett. 2000)
    703. Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells. (PubMed id 10338330)9 Rizos H....Mann G.J. (Melanoma Res. 1999)
    704. DNA methylation changes and multiple myeloma. (PubMed id 10492069)9 Ng M.H....Lo K.W. (amp 1999)
    705. Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity. (PubMed id 10207089)9 Tsubari M....Laiho M. (Mol. Cell. Biol. 1999)
    706. Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex. (PubMed id 9927424)9 Ellis M....Mittnacht S. (EMBO J. 1999)
    707. Comparative molecular genetic profiles of anaplastic astrocytomas/glioblastomas multiforme and their subsequent recurrences. (PubMed id 10022821)9 Saxena A....Ali I.U. (Oncogene 1999)
    708. The cyclin-dependent kinase inhibitors p18INK4c and p19INK4d are highly expressed in CD34+ progenitor and acute myeloid leukaemic cells but not in normal differentiated myeloid cells. (PubMed id 10468852)9 Tschan M.P....Tobler A. (Br. J. Haematol. 1999)
    709. Deletions of the INK4A gene in superficial bladder tumors. Association with recurrence. (PubMed id 10393843)9 Orlow I....Cordon-Cardo C. (Am. J. Pathol. 1999)
    710. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. (PubMed id 9916800)9 Cameron E.E....Baylin S.B. (Nat. Genet. 1999)
    711. [Study on the methylation of p15 gene CpG islands in acute leukemia: using methylation-specific PCR method]. (PubMed id 11721363)9 Zhang Y....Yu L. (Zhonghua Xue Ye Xue Za Zhi 1999)
    712. The prognostic significance of p16INK4a/p14ARF and p15INK4b deletions in adult acute lymphoblastic leukemia. (PubMed id 10430092)9 Faderl S....Albitar M. (Clin. Cancer Res. 1999)
    713. Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C). (PubMed id 10556039)9 Yuan C.... Tsai M.-D. (J. Mol. Biol. 1999)
    714. [Mutations of several tumor suppressor genes in primary retinoblastoma]. (PubMed id 11776785)9 Huang Q....Yandell D.W. (Zhonghua Zhong Liu Za Zhi 1999)
    715. Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model. (PubMed id 10490845)9 Kazianis S....Nairn R.S. (Oncogene 1999)
    716. Orthotopic models of human pancreatic cancer. (PubMed id 10415855)9 CapellA! G....LluA-s F. (Ann. N. Y. Acad. Sci. 1999)
    717. TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression. (PubMed id 9863014)9 Voss M....Naumann M. (Int. J. Oncol. 1999)
    718. Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas. (PubMed id 10416984)9 BA1schges R....Reifenberger G. (Brain Pathol. 1999)
    719. Establishment and characterization of 12 human colorectal-carcinoma cell lines. (PubMed id 10362137)9 Oh J.H....Park J.G. (Int. J. Cancer 1999)
    720. Establishment of two glioma cell lines from two surgical specimens obtained at different times from the same individual. (PubMed id 10359144)9 Onda K....Kumanishi T. (J. Neurooncol. 1999)
    721. TaqMan PCR-based gene dosage assay for predictive testing in individuals from a cancer family with INK4 locus haploinsufficiency. (PubMed id 10388473)9 Laurendeau I....Vidaud D. (Clin. Chem. 1999)
    722. Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway. (PubMed id 10469453)9 Berner J.M....Lothe R.A. (amp 1999)
    723. Establishment and characterization of human laryngeal squamous cell carcinoma cell lines. (PubMed id 10369293)9 Ku J.L....Park J.G. (Laryngoscope 1999)
    724. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. (PubMed id 10073286)9 Tsihlias J....Slingerland J. (Annu. Rev. Med. 1999)
    725. Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma. (PubMed id 10086736)9 MA...Pedersen N.T. (Leukemia 1999)
    726. Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (PubMed id 9973227)9 van Dekken H....Rosenberg C. (Cancer Res. 1999)
    727. Induced differentiation of U937 cells by 1,25-dihydroxyvitamin D3 involves cell cycle arrest in G1 that is preceded by a transient proliferative burst and an increase in cyclin expression. (PubMed id 10194452)9 Rots N.Y....Freedman L.P. (Blood 1999)
    728. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. (PubMed id 10446989)9 Melki J.R....Clark S.J. (Cancer Res. 1999)
    729. Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia. (PubMed id 10512159)9 Matherly L.H. and Taub J.W. (amp 1999)
    730. Germ-line deletion involving the INK4 locus in familial proneness to melanoma and nervous system tumors. (PubMed id 9622062)9 Bahuau M....Vidaud M. (Cancer Res. 1998)
    731. Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines. (PubMed id 9790510)9 Kumar R....Hemminki K. (amp 1998)
    732. The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia. (PubMed id 9426690)9 Hori Y....Nobori T. (Int. J. Cancer 1998)
    733. Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. (PubMed id 9598804)9 Walker G.J....Fountain J.W. (amp 1998)
    734. Expression of cell cycle regulatory genes in chronic myelogenous leukemia. (PubMed id 9825572)9 Iolascon A....Faienza M.F. (Haematologica 1998)
    735. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. (PubMed id 9843571)9 Shen X....Wang X.F. (Mol. Biol. Cell 1998)
    736. Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence. (PubMed id 9704925)9 Erickson S....GrandAcr D. (Oncogene 1998)
    737. High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene. (PubMed id 10036997)9 Uchida T....Murate T. (amp 1998)
    738. Insensitivity to growth inhibition by TGF-beta1 correlates with a lack of inhibition of the CDK2 activity in prostate carcinoma cells. (PubMed id 9794232)9 Cipriano S.C. and Chen Y.Q. (Oncogene 1998)
    739. Alterations in DNA methylation: a fundamental aspect of neoplasia. (PubMed id 9338076)9 Baylin S.B....Issa J.P. (Adv. Cancer Res. 1998)
    740. Rare loss of heterozygosity of the MTS1 and MTS2 tumor suppressor genes in differentiated human thyroid cancer. (PubMed id 9808321)9 Schulte K.M....RAPher H.D. (Horm. Metab. Res. 1998)
    741. Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines. (PubMed id 9673367)9 Fujishita T....Kobayashi M. (Anticancer Res. 1998)
    742. Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). (PubMed id 9782052)9 Baumgartner R....Holak T.A. (Structure 1998)
    743. [Inhibitors of cyclins/CDK of the 9p21 chromosomal region and malignant hemopathies]. (PubMed id 9817058)9 Quesnel B. (Bull Cancer 1998)
    744. Molecular comparison of human and mouse pulmonary adenocarcinomas. (PubMed id 9659582)9 Malkinson A.M. (Exp. Lung Res. 1998)
    745. Immediate onset of DNA synthesis in remnant rat liver after 90% hepatectomy by an administration of follistatin. (PubMed id 9875645)9 Kogure K....Kojima I. (J. Hepatol. 1998)
    746. Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia. (PubMed id 9446664)9 Gardie B....Sigaux F. (Blood 1998)
    747. An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes. (PubMed id 9501299)9 Malumbres M....Pellicer A. (Mamm. Genome 1998)
    748. Selective variegated methylation of the p15 CpG island in acute myeloid leukemia. (PubMed id 9808523)9 Dodge J.E....Futscher B.W. (Int. J. Cancer 1998)
    749. Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia. (PubMed id 9422538)9 Chilosi M....Inghirami G. (Am. J. Pathol. 1998)
    750. Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells. (PubMed id 9486855)9 Guo Y. and Kyprianou N. (amp 1998)
    751. Shortened survival after relapse in T-cell acute lymphoblastic leukemia patients with p16/p15 deletions. (PubMed id 9279366)9 Diccianni M.B....Yu A.L. (Leuk. Res. 1997)
    752. Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma. (PubMed id 9378820)9 GonzA!lez M.V....Coto E. (J. Clin. Pathol. 1997)
    753. Allelic loss determination in chronic lymphocytic leukemia by immunomagnetic bead sorting and microsatellite marker analysis. (PubMed id 9018124)9 Gartenhaus R.B. (Oncogene 1997)
    754. Deletion and differential expression of p16INK4a in mouse lung tumors. (PubMed id 9054597)9 Belinsky S.A....Tesfaigzi J. (Carcinogenesis 1997)
    755. DNA methylation changes in hematologic malignancies: biologic and clinical implications. (PubMed id 9130685)9 Issa J.P....Herman J.G. (Leukemia 1997)
    756. Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-alpha in hematopoietic cell lines. (PubMed id 9053838)9 Sangfelt O....GrandAcr D. (Oncogene 1997)
    757. Inactivation of cyclin-dependent kinase inhibitor genes and development of human acute leukemias. (PubMed id 9130611)9 Ragione F.D. and Iolascon A. (amp 1997)
    758. The role of proto-oncogenes in coronary restenosis. (PubMed id 9327828)9 Muller D.W. (Prog Cardiovasc Dis 1997)
    759. Effects of exogenous p16INK4a on growth of cells with various status of cell-cycle regulators. (PubMed id 9177281)9 Suzuki-Takahashi I....Kitagawa M. (Biochem. Biophys. Res. Commun. 1997)
    760. Analysis of p18INK4C in adult T-cell leukaemia and non-Hodgkin's lymphoma. (PubMed id 9401081)9 Hatta Y....Koeffler H.P. (Br. J. Haematol. 1997)
    761. Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes. (PubMed id 9111168)9 Nakamaki T....Koeffler H.P. (Leuk. Res. 1997)
    762. Primary malignant lymphoma of the brain: demonstration of frequent p16 and p15 gene deletions. (PubMed id 8698617)9 Kumanishi T....Washiyama K. (Jpn. J. Cancer Res. 1996)
    763. Sensitivity to transforming growth factor beta 1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC down-regulation and p21waf1 induction are important early events. (PubMed id 8891333)9 Malliri A....Ozanne B. (amp 1996)
    764. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. (PubMed id 8760298)9 Loughran O....Parkinson E.K. (Oncogene 1996)
    765. Exclusive p15INK4B gene deletions in acute lymphocytic leukemia include the E1 beta exon of the p16INK4 gene. (PubMed id 8608263)9 Heyman M....SAPderhAoll S. (Blood 1996)
    766. Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors. (PubMed id 8934552)9 Zariwala M. and Xiong Y. (Oncogene 1996)
    767. Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood. (PubMed id 8683987)9 Ohnishi H....Hayashi Y. (Leukemia 1996)
    768. Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines. (PubMed id 9414383)9 Kitahara K....Tahara E. (amp 1996)
    769. Altered regulation of G1 cyclins in oxidant-induced growth arrest of lung alveolar epithelial cells. Accumulation of inactive cyclin E-DCK2 complexes. (PubMed id 8810266)9 Corroyer S....Clement A. (J. Biol. Chem. 1996)
    770. A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. (PubMed id 8656689)9 Heyman M....Johansson B. (Leukemia 1996)
    771. Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. (PubMed id 8622065)9 Heyman M....Einhorn S. (J. Clin. Oncol. 1996)
    772. The gene for multiple familial trichoepithelioma maps to chromosome 9p21. (PubMed id 8752837)9 Harada H....Ko M.S. (J. Invest. Dermatol. 1996)
    773. Mutational analysis of the p15 and p16 genes in acute leukaemias. (PubMed id 8616035)9 Sill H....Cross N.C. (Br. J. Haematol. 1996)
    774. Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan. (PubMed id 8957063)9 Wu M.S....Lin J.T. (Jpn. J. Cancer Res. 1996)
    775. Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies. (PubMed id 8652807)9 Hangaishi A....Hirai H. (Blood 1996)
    776. [Analysis of the p16INK4, p15INK4B genes abnormality and the amplification of cyclin D1 gene in esophageal cancer]. (PubMed id 8920671)9 Takamura H....Miyazaki I. (Nippon Rinsho 1996)
    777. Role of the cyclin-dependent kinase 4 and 6 inhibitor gene family p15, p16, p18 and p19 in leukemia and lymphoma. (PubMed id 9031081)9 Siebert R....Opalka B. (amp 1996)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1030 HGNC: 1788 AceView: CDKN2AandCDKN2B Ensembl:ENSG00000147883 euGenes: HUgn1030
    ECgene: CDKN2B Kegg: 1030 H-InvDB: CDKN2B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDKN2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN2B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn2b/

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    Patent Information for CDKN2B gene:
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