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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDKN2B Gene

protein-coding GIFtS: 67
GCID: GC09M021992

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Explore 135 diseases affiliated with
CDKN2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)¹ ²		P15-INK4b¹
MTS2¹ ² ³ ⁵		CDK Inhibitory Protein²
INK4B¹ ² ⁵		CDK4B Inhibitor²
P15¹ ² ⁵		Cyclin-Dependent Kinase 4 Inhibitor B²
CDK4I¹ ²		Cyclin-Dependent Kinases 4 And 6 Binding Protein²
TP15¹ ²		P14_INK4B¹
P15INK4b¹		P14_CDK Inhibitor²
Multiple Tumor Suppressor 2² ³		P15 CDK Inhibitor²
MTS-2² ³		P15_INK4B¹
P14-INK4b¹		P15INK4B¹

External Ids:	HGNC: 1788¹	Entrez Gene: 1030²	Ensembl: ENSG00000147883⁷	OMIM: 600431⁵	UniProtKB: P42772³

Export aliases for CDKN2B gene to outside databases

Previous GC identifers: GC09M022331 GC09M022204 GC09M021994

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN2B:

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a

wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or

CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator

that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta,

which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of

this gene, which encode distinct proteins, have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle

arrest

Gene Wiki entry for CDKN2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDKN2B gene promoter:
PPAR-gamma1 Sp1 p53 AP-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDKN2B promoter sequence

Search SABiosciences Chromatin IP Primers for CDKN2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p21

CDKN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2B gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021992: view genomic region (about GC identifiers)

Start:	22,002,902 bp from pter	End:	22,009,362 bp from pter
Size:	6,461 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 4 inhibitor B

Size: 138 amino acids; 14722 Da

Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6

Subcellular location: Cytoplasm. Note=Also found in the nucleus

Secondary accessions: O15125 Q6FI09

Alternative splicing: 2 isoforms: P42772-1 P42772-2

Explore the universe of human proteins at neXtProt for CDKN2B: NX_P42772

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42772

CDKN2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004927.2 NP_511042.1

ENSEMBL proteins:

ENSP00000276925 ENSP00000369487 ENSP00000445136

Reactome Protein details: P42772
Human Recombinant Protein Products for CDKN2B:

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	Novus Biologicals CDKN2B Protein Novus Biologicals CDKN2B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDKN2B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18564286
GO:0005737	cytoplasm	IDA	16943770
GO:0005829	cytosol	TAS	--

CDKN2B for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDKN2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDKN2B for domains About GeneDecksing

2 InterPro domains/families:

IPR002110 Ankyrin_rpt

IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry P42772

ProtoNet protein and cluster: P42772

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family

Similarity: Contains 4 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDN2B_HUMAN, P42772

Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle

arrest

Genatlas biochemistry entry for CDKN2B:

cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1

checkpoint,tightly linked and highly homolog to CDKN2A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004861	cyclin-dependent protein kinase inhibitor activity	NAS	9230210
GO:0005515	protein binding	IPI	19447967
GO:0019901	protein kinase binding	IPI	8078588

CDKN2B for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for CDKN2B:

Decreased cilium length

Decreased cilium length after

Decreased telomerase activity

Increased cell number in G2M,

11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdkn2b):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
integument	mortality/aging	no phenotypic analysis	renal/urinary system	reproductive system
tumorigenesis

CDKN2B for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CDKN2B: Cdkn2b^tm1Bbd Cdkn2b^tm1Brn Cdkn2a/Cdkn2b^{Cdkn2a/tm1Brn} Cdkn2a/Cdkn2b^{Cdkn2a/tm2Brn} Cdkn2b^tm2Brn

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDKN2B

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		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN2B (see all 25):
		hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115

		SwitchGear 3'UTR luciferase reporter plasmid: CDKN2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKN2B (see all 7) OriGene shRNA RFP: CDKN2B OriGene siRNA: CDKN2B
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	1.00			Cyclin D associated events in G1	0.32
	G1-S Phase Transition	0.67			G1 Phase	0.32

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Signaling by TGF-beta Receptor Complex	0.61
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.63

Development_TGF-beta receptor signaling

Development_TGF-beta receptor signaling

1.00

Development TGF-beta receptor signaling

0.96

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CDKN2B

	Development Role of Activin A in cell differentiation and proliferation
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN2B

	G1-S Phase Transition
	Cyclins and Cell Cycle Regulation
	Molecular Mechanisms of Cancer
	Pancreatic Adenocarcinoma

1 Cell Signaling Technology (CST) Pathway for CDKN2B

Cell Cycle / Checkpoint Control

3 GeneGo (Thomson Reuters) Pathways for CDKN2B

	Cell cycle Regulation of G1/S transition (part 1)
	Development Role of Activin A in cell differentiation and proliferation
	Development TGF-beta receptor signaling

5/6 BioSystems Pathways for CDKN2B (see all 6)

	Signaling Pathways in Glioblastoma
	G1 to S cell cycle control
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Validated targets of C-MYC transcriptional repression

5/12 Reactome Pathways for CDKN2B (see all 12)

	G1 Phase
	SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
	Generic Transcription Pathway
	Mitotic G1-G1/S phases
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

4 Kegg Pathways (Kegg details for CDKN2B):

	Cell cycle
	TGF-beta signaling pathway
	Pathways in cancer
	Small cell lung cancer

CDKN2B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDKN2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for CDKN2B (P42772^{1, 2, 3} ENSP00000276925⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK4	P11802¹^,²^,³, ENSP00000257904⁴	EBI-711280,EBI-295644 MINT-8251348 I2D: score=6 STRING: ENSP00000257904
CDK8	P49336³, ENSP00000370938⁴	I2D: score=1 STRING: ENSP00000370938
ZBTB17	Q13105³, ENSP00000364895⁴	I2D: score=1 STRING: ENSP00000364895
MAGEA11	P43364³, ENSP00000347358⁴	I2D: score=4 STRING: ENSP00000347358
IKBKAP	O95163³	I2D: score=5

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IDA	8078588
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	IMP	17553787
GO:0000278	mitotic cell cycle	TAS	--
GO:0006351	transcription, DNA-dependent	TAS	--

CDKN2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDKN2B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDKN2B
10/19 Novoseek chemical compound relationships for CDKN2B gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-methylthioadenosine	75.7	10	18163473 (1), 12661005 (1), 16618910 (1), 19272367 (1) (see all 7)
5-aza-2'deoxycytidine	70.4	28	12351408 (3), 18718068 (3), 19881540 (2), 15015578 (2) (see all 12)
sodium bisulfite	64.2	3	17369979 (1), 9808523 (1), 10637497 (1)
tgf beta1	18.1	5	16871886 (2), 14693046 (1), 11082295 (1)
5-methylcytosine	16.1	1	9808523 (1)
o6-methylguanine	15.9	2	15197802 (1)
retinoic acid	7.43	3	10896783 (1), 15839997 (1)
pd 98,059	7.28	2	16322252 (1), 17513607 (1)
arsenite	4.79	3	11877046 (3)
azathioprine	2.25	1	15015578 (1)

Search CenterWatch for drugs/clinical trials and news about CDKN2B / CDN2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDKN2B gene (2 alternative transcripts):

NM_004936.3 NM_078487.2

Unigene Cluster for CDKN2B:

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Hs.72901 [show with all ESTs]

Unigene Representative Sequence: NM_078487

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000276925(uc003zpn.3 uc003zpo.3) ENST00000579591 ENST00000380142

ENST00000539462(uc022beo.1)

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		hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-605 hsa-miR-944 hsa-miR-519a hsa-miR-3122 hsa-miR-125b hsa-miR-2115

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B

Additional cDNA sequence:

AF004819.1 AF488409.1 AF488410.1 AF488411.1 AF488731.1 BC014469.1 BC018984.2 CR536529.1

L36844.1 U17075.1

5 DOTS entries:

DT.40207564 DT.91660559 DT.121147154 DT.75102662 DT.95150832

24/264 AceView cDNA sequences (see all 264):

NM_004936 CR604976 AF488410 AI160044 BM475019 CB160611 BG178804 AF488731

AF488409 CK904818 BM843979 BG031050 NM_078487 BM126144 CR536529 BQ002393

BM055160 N44213 AI859893 AU279609 AF004819 AW328497 BM831598 BC014469

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b
SP1:					-
SP2:

ECgene alternative splicing isoforms for CDKN2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDKN2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCCTGCTT

About this image

CDKN2B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Cardiomyocyte-like cells (Spontaneous differen...)

See CDKN2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDKN2B

SOURCE GeneReport for Unigene cluster: Hs.72901

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN2B (see all 9):

Oncogenes & Tumor Suppressor Genes in human mouse rat

Lung Cancer in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Leukemia in human mouse rat

Lymphoma in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2B gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDKN2B¹	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) less	70.4(n) 63.79(a)		395076 NM_204433.1 NP_989764.1
lizard (Anolis carolinensis)	Reptilia	CDKN2A⁶	--	54(a)	1 → many	2(61354584-61364127)
zebrafish (Danio rerio)	Actinopterygii	BX323448.3⁶	--	45(a)	1 → many	1(25011641-25013679)

ENSEMBL Gene Tree for CDKN2B (if available)
TreeFam Gene Tree for CDKN2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CDKN2B gene

CDKN2A² CDKN2C² CDKN2D²

9 SIMAP similar genes for CDKN2B using alignment to 4 protein entries: CDN2B_HUMAN (see all proteins):

p15 CDKN2A CDKN2D CDKN2C ANKRD54 TNKS2

ANKRD28 ANKRD65 ANK2

CDKN2B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72693618^1,2	C	--	21965746(+)	`AAAAAA/GAAAAA`	2	--	ds500¹		0	--	--	--	--
rs3217994^1,2	C,F,H	--	21966133(-)	`CACCTA/GAGTGG`	2	--	ds500¹		20		NS EA NA WA	2093
rs3217993^1,2	C	--	21966438(-)	`CCACCT/CGGCAG`	2	--	ut3¹ ese³		2		NS NA	156
rs78827673^1,2	C	--	21966538(+)	`GTTTGA/CTTTAA`	2	--	ut3¹		0	--	--	--	--
rs3217990^1,2	C,F	--	21966790(-)	`AAAATC/ACCTTA`	2	--	ut3¹		2		NS WA	168
rs79203451^1,2	C	--	21966987(+)	`TCTTTA/G/TTTCCA`	4	--	ut3¹		0	--	--	--	--
rs3217989^1,2	C,F,H	--	21967059(-)	`TGAAAA/GCTATT`	2	--	ut3¹		20		NS EA NA WA CSA	1962
rs3217988^1,2	C,F,H	--	21967351(-)	`gatagG/Atattg`	2	--	ut3¹		4		NS NA	240
rs72693621^1,2	C	--	21967353(+)	`ATACCC/TATCTC`	2	--	ut3¹		0	--	--	--	--
rs41306083^1,2		--	21967591(+)	`GTTCCT/GTTTTT`	2	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for CDKN2B (22002902 - 22009362 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CDKN2B
5 CNVs: 95873 82897 95875 33079 82898
Human Gene Mutation Database (HGMD): CDKN2B

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing CDKN2B:

Oncogenes & Tumor Suppressor Genes 384HC

Pancreatic Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN2B

DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDKN2B for disorders           About GeneDecksing

OMIM gene information: 600431    OMIM disorders: --

20/135 diseases for CDKN2B (see all 135):    About MalaCards

monoclonal gammopathy of undetermined significance malignant peripheral nerve sheath tumor adult acute lymphocytic leukemia mycosis fungoides

non-small cell lung carcinoma pleomorphic xanthoastrocytoma laryngeal squamous cell carcinoma squamous cell carcinoma

anaplastic oligodendroglioma multiple familial trichoepithelioma acute lymphocytic leukemia testicular germ cell tumor

actinic keratosis non-hodgkin lymphoma acute lymphoblastic leukemia, childhood soft tissue sarcoma

type 2 diabetes mellitus multiple endocrine neoplasia lymphoblastic leukemia trichoepithelioma

1 disease from the University of Copenhagen DISEASES database for CDKN2B:

Cancer

10/86 Novoseek disease relationships for CDKN2B gene (see all 86) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	70.7	14	16140969 (1), 17513607 (1), 9058294 (1), 9327828 (1) (see all 13)
tumors	68.2	350	7563186 (5), 11764089 (4), 8689637 (4), 9816033 (4) (see all 99)
t-all	67.9	39	9041181 (5), 9399648 (4), 10778944 (4), 8630377 (2) (see all 15)
myelodysplastic syndromes	66	21	17095538 (2), 9269757 (2), 9531610 (2), 11167795 (2) (see all 13)
multiple tumors	64.3	3	8957063 (1), 9827724 (1), 9698532 (1)
allelic imbalance	62.4	7	18564286 (1), 18712977 (1), 18331779 (1)
lymphoblastic leukemia acute	61.2	29	7780130 (2), 7994022 (2), 8683987 (1), 8816064 (1) (see all 22)
allelic loss	61.1	6	7780130 (1), 9501299 (1), 11874489 (1), 8855819 (1)
primary tumor	60.1	12	7882348 (1), 8760309 (1), 9698478 (1), 8689636 (1) (see all 9)
lymphoblastic leukemia acute childhood	58.2	14	9399648 (2), 9737691 (2), 8816064 (1), 12661005 (1) (see all 8)

Genetic Association Database (GAD): CDKN2B
Human Genome Epidemiology (HuGE) Navigator: CDKN2B (146 documents)

Export disorders for CDKN2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDKN2B gene, integrated from 9 sources (see all 777):
(articles sorted by number of sources associating them with CDKN2B)

Utopia: connect your pdf to the dynamic
world of online information

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PubMed id 8078588)^{1, 2, 3, 9} Hannon G.J. and Beach D. (1994)
Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)^{1, 4, 9} Soto Martinez J.L....Lopez-Nevot M.A. (2005)
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (PubMed id 7882351)^{1, 2, 9} Okamoto A.... Harris C.C. (1995)
Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. (PubMed id 10892805)^{1, 2, 9} Yuan C.... Tsai M.D. (2000)
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)^{1, 2, 9} Guan K.-L.... Xiong Y. (1994)
Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694)^{1, 4} Starinsky S....Friedman E. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. (PubMed id 12556369)^{1, 4} Hearle N.... Houlston R.S. (2003)
A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. (PubMed id 11668523)^{1, 4} Kumar R....Hemminki K. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1030	HGNC: 1788	AceView: CDKN2AandCDKN2B	Ensembl:ENSG00000147883	euGenes: HUgn1030
ECgene: CDKN2B	Kegg: 1030	H-InvDB: CDKN2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDKN2B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDKN2B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn2b/

Intellectual Property for CDKN2B gene
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Patent Information for CDKN2B gene:
Search GeneIP for patents involving CDKN2B

GeneCards and IP:
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CDKN2B Gene

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

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CDKN2B (Gene Symbol)
Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)
MTS2
INK4B
P15
CDK4I
TP15
P15INK4b
Multiple Tumor Suppressor 2
MTS-2
P14-INK4b
P15-INK4b
CDK Inhibitory Protein
CDK4B Inhibitor
Cyclin-Dependent Kinase 4 Inhibitor B
Cyclin-Dependent Kinases 4 And 6 Binding Protein
P14_INK4B
P14_CDK Inhibitor
P15 CDK Inhibitor
P15_INK4B
P15INK4B

Lymphoblastic Leukemia Acute Childhood
Anaplastic Oligodendroglioma
Microsatellite Instability
Retinoblastoma
GASTRIC TUMOR
Lymphoma T-Cell
Anaplastic Astrocytoma
Multiple tumors
NSCLC
primary tumor
Mycosis Fungoides
Carcinoma Transitional Cell
Cancer
Monoclonal gammopathy
somatic mutations
ADENOCARCINOMA GASTRIC
Lymphoma
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
Ependymoma
HNSCC
carcinoma transitional cell bladder
Bladder Tumors
SKIN MELANOMA
MYELOMA
prostate cancer
Malignant mesothelioma
Tumors
Lymphoblastic Leukemia Acute
Nervous System Tumor
Glioblastoma
Anemia Refractory
MPNST
Lymphoma T-Cell Cutaneous
Malignant Glioma
neoplastic transformation
Glioblastoma Multiforme
Gastric Cancer
lymphoid neoplasm
Myeloid Leukemia
Brain Tumors
Melanoma
Colon Cancer
bladder cancer
ESOPHAGEAL CARCINOMA
Medulloblastoma
Leukemia Lymphocytic Chronic
Adenoma Follicular
Glioma
PITUITARY ADENOMA
Monosomy
Oligodendroglioma
Astrocytoma
Carcinoma
B-ALL
ACUTE LEUKEMIA
Leukemia
Myeloid Leukemia Chronic
Blast Crisis
Allelic Loss
Hematopoietic Malignancies
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
metastatic melanoma
laryngeal squamous cell carcinoma
AML adult
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Hematologic Malignancies
Cancer Lung
oligodendroglial tumors
Meningioma
anaplastic meningioma
Lymphoma B-Cell
T-ALL
AML childhood
Carcinoma Squamous Cell
Allelic Imbalance
Lymphoma Large Cell Diffuse
Chromosomal Aberrations
Lymphoma Non-Hodgkins
Adult Acute Lymphocytic Leukemia
leukemogenesis
Plasmacytoma
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC
Papilloma

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CDKN2B Gene

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

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