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Aliases for CDKN2B Gene

Aliases for CDKN2B Gene

  • Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4) 2 3
  • Multiple Tumor Suppressor 2 3 4
  • P14-INK4b 3 4
  • P15-INK4b 3 4
  • P15INK4b 3 4
  • MTS-2 3 4
  • MTS2 3 4
  • Cyclin-Dependent Kinases 4 And 6 Binding Protein 3
  • CDK Inhibitory Protein 3
  • P14_CDK Inhibitor 3
  • P15 CDK Inhibitor 3
  • CDK4B Inhibitor 3
  • P14_INK4B 3
  • P15_INK4B 3
  • CDK4I 3
  • INK4B 3
  • TP15 3
  • P15 3

External Ids for CDKN2B Gene

Previous GeneCards Identifiers for CDKN2B Gene

  • GC09M022331
  • GC09M022204
  • GC09M021994

Summaries for CDKN2B Gene

Entrez Gene Summary for CDKN2B Gene

  • This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKN2B Gene

CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4)) is a Protein Coding gene. Diseases associated with CDKN2B include scrotal carcinoma and multiple endocrine neoplasia 1. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot for CDKN2B Gene

  • Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest

Gene Wiki entry for CDKN2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2B Gene

Genomics for CDKN2B Gene

Regulatory Elements for CDKN2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDKN2B Gene

Chromosome:
9
Start:
22,002,903 bp from pter
End:
22,009,363 bp from pter
Size:
6,461 bases
Orientation:
Minus strand

Genomic View for CDKN2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2B Gene

Proteins for CDKN2B Gene

  • Protein details for CDKN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42772-CDN2B_HUMAN
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor B
    Protein Accession:
    P42772
    Secondary Accessions:
    • O15125
    • Q6FI09

    Protein attributes for CDKN2B Gene

    Size:
    138 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    • Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6

    Alternative splice isoforms for CDKN2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDKN2B Gene

Proteomics data for CDKN2B Gene at MOPED

Post-translational modifications for CDKN2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CDKN2B (p15INK4b/CDKN2B)

No data available for DME Specific Peptides for CDKN2B Gene

Domains & Families for CDKN2B Gene

Protein Domains for CDKN2B Gene

Suggested Antigen Peptide Sequences for CDKN2B Gene

Graphical View of Domain Structure for InterPro Entry

P42772

UniProtKB/Swiss-Prot:

CDN2B_HUMAN :
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with CDKN2B: view

No data available for Gene Families for CDKN2B Gene

Function for CDKN2B Gene

Molecular function for CDKN2B Gene

GENATLAS Biochemistry:
cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1 checkpoint,tightly linked and highly homolog to CDKN2A
UniProtKB/Swiss-Prot Function:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest

Gene Ontology (GO) - Molecular Function for CDKN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity NAS 9230210
GO:0005515 protein binding IPI 16169070
GO:0019901 protein kinase binding IPI 8078588
genes like me logo Genes that share ontologies with CDKN2B: view
genes like me logo Genes that share phenotypes with CDKN2B: view

Animal Models for CDKN2B Gene

MGI Knock Outs for CDKN2B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKN2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDKN2B Gene

Localization for CDKN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2B Gene

Cytoplasm. Note=Also found in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2B Gene COMPARTMENTS Subcellular localization image for CDKN2B gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDKN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9230210
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 9230210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDKN2B: view

Pathways & Interactions for CDKN2B Gene

genes like me logo Genes that share pathways with CDKN2B: view

PCR Array Products

SIGNOR curated interactions for CDKN2B Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDKN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8078588
GO:0000086 G2/M transition of mitotic cell cycle IMP 17553787
GO:0000278 mitotic cell cycle TAS --
GO:0001889 liver development IEA --
GO:0006351 transcription, DNA-templated TAS --
genes like me logo Genes that share ontologies with CDKN2B: view

Drugs & Compounds for CDKN2B Gene

(8) Drugs for CDKN2B Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 145
Cytarabine Approved, Investigational Pharma 995
Doxycycline Approved, Investigational Pharma 204
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1387
estrogen Pharma 0

(11) Additional Compounds for CDKN2B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Aza-2deoxycytidine
5-methylcytosine
  • 4-Amino-5-methyl-2-(1H)-Pyrimidinone
  • 4-Amino-5-methyl-2-pyrimidinol
  • 5-Methyl-Cytosine
  • 5-Methylcytosine
  • 5-Methylcytosine>96
554-01-8
5-methylthioadenosine
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
dihydrofolate
genes like me logo Genes that share compounds with CDKN2B: view

Transcripts for CDKN2B Gene

mRNA/cDNA for CDKN2B Gene

Unigene Clusters for CDKN2B Gene

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKN2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for CDKN2B Gene

GeneLoc Exon Structure for
CDKN2B
ECgene alternative splicing isoforms for
CDKN2B

Expression for CDKN2B Gene

mRNA expression in normal human tissues for CDKN2B Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2B Gene

This gene is overexpressed in Esophagus - Mucosa (x7.7) and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for CDKN2B Gene

This gene is overexpressed in Liver, secretome (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDKN2B Gene



SOURCE GeneReport for Unigene cluster for CDKN2B Gene Hs.72901

mRNA Expression by UniProt/SwissProt for CDKN2B Gene

P42772-CDN2B_HUMAN
Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.
genes like me logo Genes that share expression patterns with CDKN2B: view

Protein tissue co-expression partners for CDKN2B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDKN2B Gene

Orthologs for CDKN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDKN2B 35
  • 86.77 (n)
  • 86.26 (a)
CDKN2B 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2B 35
  • 87.44 (n)
  • 83.33 (a)
CDKN2A 36
  • 69 (a)
OneToMany
CDKN2B 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdkn2b 35
  • 84.37 (n)
  • 88.28 (a)
Cdkn2b 16
Cdkn2b 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDKN2B 35
  • 94.2 (n)
  • 93.48 (a)
CDKN2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkn2b 35
  • 84.11 (n)
  • 88.28 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
CDKN2A 36
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDKN2B 35
  • 70.03 (n)
  • 63.87 (a)
CDKN2B 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
Species with no ortholog for CDKN2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDKN2B Gene

ENSEMBL:
Gene Tree for CDKN2B (if available)
TreeFam:
Gene Tree for CDKN2B (if available)

Paralogs for CDKN2B Gene

Paralogs for CDKN2B Gene

(10) SIMAP similar genes for CDKN2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDKN2B: view

Variants for CDKN2B Gene

Sequence variations from dbSNP and Humsavar for CDKN2B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_001488 Lung adenocarcinoma
VAR_001489 Lung adenocarcinoma

Structural Variations from Database of Genomic Variants (DGV) for CDKN2B Gene

Variant ID Type Subtype PubMed ID
nsv8426 CNV Loss 18304495
nsv892745 CNV Gain 21882294
nsv892746 CNV Loss 21882294
nsv892747 CNV Gain 21882294
nsv824877 CNV Loss 20364138
nsv892748 CNV Loss 21882294

Variation tolerance for CDKN2B Gene

Residual Variation Intolerance Score: 41.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKN2B Gene

HapMap Linkage Disequilibrium report
CDKN2B
Human Gene Mutation Database (HGMD)
CDKN2B

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN2B Gene

Disorders for CDKN2B Gene

MalaCards: The human disease database

(37) MalaCards diseases for CDKN2B Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
scrotal carcinoma
  • carcinoma of scrotum
multiple endocrine neoplasia 1
  • multiple endocrine neoplasia type 1
adult acute lymphocytic leukemia
  • adult acute lymphoid leukemia
atypical neurofibroma
skin melanoma
  • melanoma
- elite association

Relevant External Links for CDKN2B

Genetic Association Database (GAD)
CDKN2B
Human Genome Epidemiology (HuGE) Navigator
CDKN2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDKN2B
genes like me logo Genes that share disorders with CDKN2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2B Gene

Publications for CDKN2B Gene

  1. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML. (PMID: 20190193) Paul T.A. … Wolff L. (Blood 2010) 23 67
  2. Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition. (PMID: 19881540) Lakshmikuttyamma A. … Geyer C.R. (Oncogene 2010) 23 67
  3. CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus. (PMID: 20051228) Rodriguez C. … Piette J. (Biochem. Biophys. Res. Commun. 2010) 23 67
  4. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. (PMID: 19164764) Basu S. … Dong F. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  5. DNA hypermethylation profiles in squamous cell carcinoma of the vulva. (PMID: 19047905) Stephen J.K. … Worsham M.J. (Int. J. Gynecol. Pathol. 2009) 23 67

Products for CDKN2B Gene

Sources for CDKN2B Gene

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