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Aliases for CDKN2B Gene

Aliases for CDKN2B Gene

  • Cyclin Dependent Kinase Inhibitor 2B 2 3 5
  • Cyclin-Dependent Kinase Inhibitor 2B (P15, Inhibits CDK4) 2 3
  • Multiple Tumor Suppressor 2 3 4
  • P14-INK4b 3 4
  • P15-INK4b 3 4
  • P15INK4b 3 4
  • MTS-2 3 4
  • MTS2 3 4
  • Cyclin-Dependent Kinases 4 And 6 Binding Protein 3
  • Cyclin-Dependent Kinase 4 Inhibitor B 3
  • CDK Inhibitory Protein 3
  • P14_CDK Inhibitor 3
  • P15 CDK Inhibitor 3
  • CDK4B Inhibitor 3
  • P14_INK4B 3
  • P15_INK4B 3
  • CDK4I 3
  • INK4B 3
  • TP15 3
  • P15 3

External Ids for CDKN2B Gene

Previous GeneCards Identifiers for CDKN2B Gene

  • GC09M022331
  • GC09M022204
  • GC09M021994

Summaries for CDKN2B Gene

Entrez Gene Summary for CDKN2B Gene

  • This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKN2B Gene

CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) is a Protein Coding gene. Diseases associated with CDKN2B include Adult Acute Lymphocytic Leukemia and Scrotal Carcinoma. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and HTLV-I infection. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2A.

UniProtKB/Swiss-Prot for CDKN2B Gene

  • Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Gene Wiki entry for CDKN2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2B Gene

Genomics for CDKN2B Gene

Regulatory Elements for CDKN2B Gene

Enhancers for CDKN2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F022039 0.9 Ensembl ENCODE 26.9 -31.7 -31690 3.7 GATAD2A SOX13 SOX5 FOXA3 CEBPB DPF2 CEBPG EP300 RARA JUND CDKN2B CDKN2A CDKN2B-AS1 MTAP CDKN2A-AS1 UBA52P6 ENSG00000274055
GH09F021986 1 Ensembl ENCODE 20.2 +21.6 21559 2.8 TBP PKNOX1 NFRKB RFX5 YY1 MAFK ZBTB20 NFE2L2 L3MBTL2 GFI1B CDKN2B CDKN2A-AS1 UBA52P6 CDKN2B-AS1 PIR47863 GC09M021977
GH09F022007 1 ENCODE 16.5 +0.4 383 2.3 ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 GLIS2 ZNF143 ZNF263 SP3 CDKN2B ENSG00000266446
GH09F022237 1.5 FANTOM5 Ensembl ENCODE 10.8 -230.3 -230261 4.8 TBP PKNOX1 TBL1XR1 INSM2 KLF17 FEZF1 BMI1 ZNF2 RAD21 ZNF335 UBA52P6 CDKN2B DMRTA1 ENSG00000236921 GC09M022287
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDKN2B on UCSC Golden Path with GeneCards custom track

Promoters for CDKN2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001469827 1163 3600 PKNOX1 ARID4B SIN3A ZNF48 ZNF2 YY1 GTF3C2 ZNF121 GLIS2 ZNF143

Genomic Location for CDKN2B Gene

22,002,903 bp from pter
22,009,363 bp from pter
6,461 bases
Minus strand

Genomic View for CDKN2B Gene

Genes around CDKN2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2B Gene

Proteins for CDKN2B Gene

  • Protein details for CDKN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor B
    Protein Accession:
    Secondary Accessions:
    • O15125
    • Q6FI09

    Protein attributes for CDKN2B Gene

    138 amino acids
    Molecular mass:
    14722 Da
    Quaternary structure:
    • Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6.

    Alternative splice isoforms for CDKN2B Gene


neXtProt entry for CDKN2B Gene

Post-translational modifications for CDKN2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDKN2B Gene

Domains & Families for CDKN2B Gene

Protein Domains for CDKN2B Gene


Suggested Antigen Peptide Sequences for CDKN2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
  • Contains 4 ANK repeats.
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with CDKN2B: view

No data available for Gene Families for CDKN2B Gene

Function for CDKN2B Gene

Molecular function for CDKN2B Gene

GENATLAS Biochemistry:
cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through the G1 checkpoint,tightly linked and highly homolog to CDKN2A
UniProtKB/Swiss-Prot Function:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Gene Ontology (GO) - Molecular Function for CDKN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity NAS 9230210
GO:0005515 protein binding IPI 16169070
GO:0016301 kinase activity IEA --
GO:0019901 protein kinase binding IPI 8078588
genes like me logo Genes that share ontologies with CDKN2B: view
genes like me logo Genes that share phenotypes with CDKN2B: view

Human Phenotype Ontology for CDKN2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDKN2B Gene

MGI Knock Outs for CDKN2B:

Animal Model Products

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDKN2B Gene

Localization for CDKN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2B Gene

Cytoplasm. Note=Also found in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKN2B gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CDKN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9230210
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 9230210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDKN2B: view

Pathways & Interactions for CDKN2B Gene

genes like me logo Genes that share pathways with CDKN2B: view

SIGNOR curated interactions for CDKN2B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDKN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8078588
GO:0000086 G2/M transition of mitotic cell cycle IMP 17553787
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IMP 17553787
GO:0007093 mitotic cell cycle checkpoint IMP 17553787
genes like me logo Genes that share ontologies with CDKN2B: view

Drugs & Compounds for CDKN2B Gene

(8) Drugs for CDKN2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for CDKN2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDKN2B: view

Transcripts for CDKN2B Gene

mRNA/cDNA for CDKN2B Gene

Unigene Clusters for CDKN2B Gene

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -

Relevant External Links for CDKN2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKN2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDKN2B Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2B Gene

This gene is overexpressed in Esophagus - Mucosa (x7.7) and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for CDKN2B Gene

This gene is overexpressed in Liver, secretome (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDKN2B Gene

Protein tissue co-expression partners for CDKN2B Gene

NURSA nuclear receptor signaling pathways regulating expression of CDKN2B Gene:


SOURCE GeneReport for Unigene cluster for CDKN2B Gene:


mRNA Expression by UniProt/SwissProt for CDKN2B Gene:

Tissue specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.
genes like me logo Genes that share expression patterns with CDKN2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDKN2B Gene

Orthologs for CDKN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDKN2B 34 35
  • 94.2 (n)
(Canis familiaris)
Mammalia CDKN2B 34 35
  • 87.44 (n)
  • 69 (a)
(Bos Taurus)
Mammalia CDKN2B 34 35
  • 86.77 (n)
(Mus musculus)
Mammalia Cdkn2b 34 16 35
  • 84.37 (n)
(Rattus norvegicus)
Mammalia Cdkn2b 34
  • 84.11 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
(Gallus gallus)
Aves CDKN2B 34 35
  • 70.03 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
Species where no ortholog for CDKN2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDKN2B Gene

Gene Tree for CDKN2B (if available)
Gene Tree for CDKN2B (if available)

Paralogs for CDKN2B Gene

Paralogs for CDKN2B Gene

(10) SIMAP similar genes for CDKN2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDKN2B: view

Variants for CDKN2B Gene

Sequence variations from dbSNP and Humsavar for CDKN2B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_001488 Lung adenocarcinoma
VAR_001489 Lung adenocarcinoma
rs1063192 -- 22,003,368(-) ACAAC(C/T)TGATA intron-variant, utr-variant-3-prime
rs10965209 -- 22,004,670(+) CTTTA(A/G)TTTGT intron-variant, utr-variant-3-prime
rs111751296 -- 22,004,972(+) TTCTT(C/T)CTCAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDKN2B Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv1018514 CNV gain 25217958
nsv613760 CNV loss 21841781
nsv824877 CNV loss 20364138
nsv8426 CNV loss 18304495

Variation tolerance for CDKN2B Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKN2B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN2B Gene

Disorders for CDKN2B Gene

MalaCards: The human disease database

(36) MalaCards diseases for CDKN2B Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adult acute lymphocytic leukemia
  • adult acute lymphoid leukemia
scrotal carcinoma
  • carcinoma of scrotum
skin melanoma
  • melanoma
malignant melanoma, somatic
  • dysplastic nevus syndrome
multiple endocrine neoplasia 1
  • multiple endocrine neoplasia, type i
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDKN2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDKN2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2B Gene

Publications for CDKN2B Gene

  1. MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. (PMID: 19272367) Yang X.C. … Wang X.F. (Clin. Biochem. 2009) 3 22 46 64
  2. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PMID: 8078588) Hannon G.J. … Beach D. (Nature 1994) 2 3 4 64
  3. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. (PMID: 22419738) Osman W. … Nakamura Y. (Hum. Mol. Genet. 2012) 3 46 64
  4. Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. (PMID: 19794065) Lango Allen H. … Weedon M.N. (Diabetes 2010) 3 46 64
  5. Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. (PMID: 19933996) Zhao J. … Grant S.F. (Diabetes 2010) 3 46 64

Products for CDKN2B Gene

Sources for CDKN2B Gene

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