V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CDKN2B Gene

protein-coding GIFtS: 66

GC09M021992

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDK4I ^¹, ²
INK4B ^¹, ², ⁵
MTS-2 ^³
MTS2 ^¹, ², ³, ⁵
OTTHUMP00000021154 ^²
OTTHUMP00000021155 ^²
P15 ^¹, ², ⁵
TP15 ^¹, ²
p14-INK4b ^³
p14_INK4B ^²
p15-INK4b ^³
p15INK4B ^³
p15INK4b ^¹, ²
p15_INK4B ^²

Descriptions
CDK inhibitory protein ^²
CDK4B inhibitor ^²
Multiple tumor suppressor 2 ^², ³
cyclin-dependent kinase 4 inhibitor B ^²
cyclin-dependent kinase inhibitor 2B ^²
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) ^²
cyclin-dependent kinases 4 and 6 binding protein ^²
p14_CDK inhibitor ^²
p15 CDK inhibitor ^²

External Ids
HGNC: 1788¹
Entrez Gene: 1030²
UniProtKB: P42772³
Ensembl: ENSG00000147883⁷

Search outside databases for aliases for CDKN2B gene

Previous GC identifers: GC09M022331 GC09M022204 GC09M021994

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDKN2B:

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated

and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor,

which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the

encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The

expression of this gene was found to be dramatically induced by TGF beta, which suggested its role

in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this

gene, which encode distinct proteins, have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta

induced cell cycle arrest

Gene Wiki entry for CDKN2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDKN2B gene

Entrez Gene cytogenetic band: 9p21 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p21

CDKN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M021992: (about GC identifiers)

Start:	21,992,902 bp from pter
End:	21,999,312 bp from pter
Size:	6,411 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 4 inhibitor B

Size: 138 amino acids; 14722 Da

Subunit: Heterodimer of CDKN2B with CDK4 or CDK6

Secondary accessions: Q6FI09

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004927.2 NP_511042.1

ENSEMBL proteins:

ENSP00000369487 ENSP00000276925

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (p15 INK4b)
	Human Recombinant Proteins from Abnova (CDKN2B)

OriGene Purified Recombinant Human Protein: CDKN2B

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	16943770

About this table

Antibodies for CDKN2B:

	Invitrogen Antibodies for CDKN2B
	Millipore Mono- and Polyclonal Antibodies for the study of CDKN2B
	Sigma-Aldrich Antibodies for CDKN2B
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDKN2B (p15INK4B)
	Antibodies from Abcam (p15 INK4b), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDKN2B)
	Novus Biologicals Antibodies for CDKN2B

Assays for CDKN2B:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CDKN2B
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P42772

ProtoNet protein and cluster: P42772

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family

Similarity: Contains 4 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDKN2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004936

Applied Biosystems Silencer® siRNAs for CDKN2B

Sigma-Aldrich siRNA and siRNA Panels for CDKN2B

Sigma-Aldrich shRNA Panels and shRNA for CDKN2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDKN2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004936
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004936
untagged cDNA clones in CMV expression vector (see all 2): NM_004936

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004936

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta

induced cell cycle arrest

Genatlas biochemistry entry for CDKN2B:

cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor,p15,regulator of cell cycle,passage through

the G1 checkpoint,tightly linked and highly homolog to CDKN2A

9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cdkn2b):

endocrine/exocrine gland	growth/size	hematopoietic system	immune system	no phenotypic analysis
renal/urinary system	reproductive system	skin/coat/nails	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IDA	8078588
GO:0005515	protein binding	IPI	16169070
GO:0019901	protein kinase binding	IPI	8078588

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for CDKN2B (Your Favorite Gene powered by Ingenuity)

Cell Cycle: G1/S Checkpoint Regulation
Glioma Signaling
Small Cell Lung Cancer Signaling
Molecular Mechanisms of Cancer

GeneDecks CDKN2B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDKN2B

5/52 Interacting proteins for CDKN2B (P42772¹ ENSP00000276925³) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK4	P11802¹, ENSP00000257904³	EBI-711280, EBI-295644 STRING (score=.999)
CDK6	ENSP00000265734³	STRING (score=.999)
CDKN2A	ENSP00000355153³	STRING (score=.995)
ZBTB17	ENSP00000364885³	STRING (score=.984)
CCND1	ENSP00000227507³	STRING (score=.983)

About this table

5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IDA	8078588
GO:0000086	G2/M transition of mitotic cell cycle	IMP	17553787
GO:0007050	cell cycle arrest	IMP	17553787
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	16943770
GO:0031575	G1/S transition checkpoint	IMP	17553787

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CDKN2B:

Inhibitor

Browse Tocris compounds for CDKN2B
8 Novoseek chemical compound relationships for CDKN2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1	20.02	5	16871886 (2), 14693046 (1), 11082295 (1)
5-methylcytosine	17.80	1	9808523 (1)
o6-methylguanine	17.33	2	15197802 (1)
pd 98,059	9.15	2	16322252 (1), 17513607 (1)
p003	0.00	1	12750706 (1)
threonine	0.00	1	8703847 (1)
dihydrofolate	0.00	3	11380466 (2), 11106643 (1)
tyrosine	0.00	1	11853794 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDKN2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004936

Sigma-Aldrich siRNA and siRNA Panels for CDKN2B

Sigma-Aldrich shRNA Panels and shRNA for CDKN2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004936 NM_078487

REFSEQ mRNAs for CDKN2B gene (2 alternative transcripts):

NM_004936.3 NM_078487.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004936 NM_078487

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004936
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004936
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004936

Additional cDNA sequence:

AF004819.1 AF488409.1 AF488410.1 AF488411.1 AF488731.1 BC014469.1 BC018984.2 CR536529.1

L36844.1 U17075.1

5 DOTS entries:

DT.40207564 DT.91660559 DT.95150832 DT.121147154 DT.75102662

24/264 AceView cDNA sequences (see all 264 ):

N44213 BM843979 AA826886 AF488410 BQ441101 BX502404 NM_004936 BF000057

BM126144 CR536529 AW328497 AF004819 BM831598 CK904818 AI859893 NM_078487

AI160044 BM701855 BM719878 CR604976 BG031050 BG178804 BM055160 CB160611

highest scoring ESTs for CDKN2B:

AF004819 L36844 AA975511 AI983437 AU100332 AU279609 BC014469 BG718749 BG765173 BG767760

Unigene Cluster for CDKN2B:

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Hs.72901 [show with all ESTs]

Unigene Representative Sequence: NM_078487

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B

ExUns:	1a	·	1b	·	1c	^	2a	·	2b
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for CDKN2B

2 Ensembl transcripts including schematic representations:

ENST00000380142 ENST00000276925

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDKN2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDKN2B

¹ / ² / ³

9 probe-sets matching CDKN2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34624_at²^{, 3}	U95-A	1	1.00	1.00	-0.06	0.11	AF004819	1.00	0.90	0.95	1
1607_at²^{, 3}	U95-A	1	1.00	1.00	-0.17	0.15	L36844	1.00	0.90	0.95	1
75652_at²^{, 3}	U95-E	2	1.00	0.97	0.92	0.82	AI983437	0.80	0.88	0.84	1
54310_at²^{, 3}	U95-B	1	0.94	1.00	0.96	0.74	AA975511	0.80	0.88	0.84	1
73132_r_at²^{, 3}	U95-E	6	0.81	0.44	0.41	1.46	AA909181	0.40	0.33	0.37	2
236313_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW444761	0.60	0.83	0.73	1
207530_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004936	0.60	0.83	0.73	1
236313_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207530_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDKN2B for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTCCTGCTT

SOURCE GeneReport for Unigene cluster: Hs.72901
Expression variation in blood from EXPOLDB for CDKN2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDKN2B gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	CDKN2B¹	--	cyclin-dependent kinase inhibitor 2B (p15, inhibits more	86.77(n) 86.26(a)	527124 NM_001075894.1 NP_001069362.1
rat (Rattus norvegicus)	Cdkn2b¹	--	cyclin-dependent kinase inhibitor 2B (p15, inhibits more	84.11(n) 88.28(a)	25164 NM_130812.1 NP_570825.1
mouse (Mus musculus)	Cdkn2b^{1, 5}	4 (42.70 cM)⁵	cyclin-dependent kinase inhibitor 2B (p15, inhibits more^{1, 5}	84.37(n)¹ 88.28(a)¹	12579¹ NM_007670.3¹ NP_031696.1¹ AF015460⁵ AF059567⁵ (see all 18)
chicken (Gallus gallus)	CDKN2A¹	--	cyclin-dependent kinase inhibitor 2A (melanoma, p16, more	70.4(n) 63.79(a)	395076 NM_204433.1 NP_989764.1

About this table Species with no ortholog for CDKN2B

ENSEMBL Gene Tree for CDKN2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDKN2B gene

CDKN2C² CDKN2D²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Polymorphism: Genetic variations in CDKN2B may underlie susceptibility to uveal melanoma

[MIM:155720]. Uveal melanoma is the most common type of ocular malignant tumor, consisting of

overgrowth of uveal melanocytes and often preceded by a uveal nevus

10/79 NCBI SNPs in CDKN2B are shown (see all 79 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2069418^1,2	A,C,F,H	21999698(-)	`AGAAAG/CACGGA`	2	--	ng3¹		13	NA EU EA WA NS	2680
	rs1063192^1,2	C,F,H,O	21993367(-)	`ACAACT/CTGATA`	2	--	ut3¹		15	NS MN NA EU EA WA	1502
--	rs2069416^1,2	A,C,F,H	22000004(-)	`TCTTAA/C/TAGTAT`	2	--	ng3¹		7	NA EU EA WA NS	1966
	rs495490^1,2	C,F,H	22000412(-)	`AAAAAT/CTGTTC`	2	--	ng3¹		19	EA NA EU WA NS	1634
	rs3217989^1,2	C,F,H	21993790(-)	`TGAAAA/GCTATT`	2	--	ut3¹		11	NS EU EA WA	1068
	rs3217986^1,2	C,F,H	21995330(-)	`AGAGGA/CTGTGC`	2	--	ut3¹ ese³		22	NS EU EA WA NA	2010
	rs3217994^1,2	C,F,H	21992864(-)	`CACCTA/GAGTGG`	2	--	ng5¹		12	NS EU EA WA NA	1123
	rs3808845^1,2	C,F,H	22000575(+)	`AAAAAG/ACTCTT`	2	--	ng3¹ tfbs³		4	EU EA WA	416
	rs3217973^1,2	C,F,H	21999960(-)	`ACTCTC/TAATCT`	2	--	ng3¹		9	NS EU EA WA	972
	rs3217992^1,2	C,F,H	21993223(-)	`GTATTG/AAAATA`	2	--	ut3¹		14	NS EA NA EU WA	1245

About this table

HapMap Linkage Disequilibrium images for CDKN2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600431

UniProtKB/Swiss-Prot: CDN2B_HUMAN, P42772

Defects in CDKN2B are involved in tumor formation

10/86 Novoseek disease relationships for CDKN2B gene (see all 86 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	71.64	14	16140969 (1), 17513607 (1), 9058294 (1), 9327828 (1) (see all 13)
t-all	69.19	39	9041181 (5), 9399648 (4), 10778944 (4), 8630377 (2) (see all 15)
tumors	68.54	343	7563186 (5), 11764089 (4), 8689637 (4), 9816033 (4) (see all 99)
myelodysplastic syndromes	66.17	21	17095538 (2), 9269757 (2), 9531610 (2), 11167795 (2) (see all 13)
multiple tumors	65.60	3	8957063 (1), 9827724 (1), 9698532 (1)
lymphoblastic leukemia acute	61.80	27	7780130 (2), 7994022 (2), 8683987 (1), 8816064 (1) (see all 21)
allelic loss	61.79	6	7780130 (1), 9501299 (1), 11874489 (1), 8855819 (1)
allelic imbalance	61.41	7	18564286 (1), 18712977 (1), 18331779 (1)
primary tumor	61.06	12	7882348 (1), 8760309 (1), 9698478 (1), 8689636 (1) (see all 9)
lymphoblastic leukemia acute childhood	59.77	14	9399648 (2), 9737691 (2), 8816064 (1), 12661005 (1) (see all 8)

About this table

Human Gene Mutation Database: CDKN2B
Genetic Association Database: CDKN2B
Human Genome Epidemiology Navigator: CDKN2B (66 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

5-Azacytidine in Myelodysplastic Syndromes: Correlation Between Clinical Responses and CDKN2B Promoter Methylation: Presented at MDS

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/631 PubMed articles for CDKN2B gene (see all 631 ):

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (PubMed id 8078588)^{1, 2, 3, 4} Hannon G.J. and Beach D. (1994)
Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. (PubMed id 12556369)^{3, 4, 6} Hearle N.... Houlston R.S. (2003)
Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)^{1, 3, 6} Soto Martinez J.L....Lopez-Nevot M.A. (2005)
Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. (PubMed id 10892805)^{1, 3, 4} Yuan C.... Tsai M.D. (2000)
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (PubMed id 7882351)^{1, 3, 4} Okamoto A.... Harris C.C. (1995)
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. (PubMed id 8001816)^{1, 3, 4} Guan K.-L.... Xiong Y. (1994)
Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694)^{3, 6} Starinsky S....Friedman E. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. (PubMed id 11668523)^{3, 6} Kumar R....Hemminki K. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1030	HGNC: 1788	AceView: CDKN2AandCDKN2B	Ensembl:ENSG00000147883	euGenes: HUgn1030
ECgene: CDKN2B	H-InvDB: CDKN2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDKN2B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn2b/

Licensable Technologies for CDKN2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDKN2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDKN2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDKN2B		Antibodies for CDKN2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDKN2B		Small molecules for CDKN2B
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDKN2B)
	Antibodies (CDKN2B)
	Chimera RNAi (CDKN2B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDKN2B (p15INK4B)

	Recombinant Proteins (p15 INK4b)
	Antibodies (p15 INK4b)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CDKN2B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDKN2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDKN2B Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CDKN2B Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CDKN2B

Summaries
for CDKN2B

Genomic Location
for CDKN2B

Proteins
for CDKN2B

Protein Domains/
Families
for CDKN2B

Gene Function
for CDKN2B

Pathways & Interactions
for CDKN2B

Drugs & Compounds
for CDKN2B

Transcripts
for CDKN2B

Expression
for CDKN2B

Orthologs
for CDKN2B

Paralogs
for CDKN2B

SNPs/Variants
for CDKN2B

Disorders & Mutations
for CDKN2B

Medical News
for CDKN2B

Publications
for CDKN2B

Search for CDKN2B

Genome Databases showing CDKN2B

Other Databases showing CDKN2B

Specialized Databases showing CDKN2B

Licensable Technologies
for CDKN2B

Services
for CDKN2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDKN2B (Gene Symbol)
CDK4I
INK4B
MTS-2
MTS2
OTTHUMP00000021154
OTTHUMP00000021155
P15
TP15
p14-INK4b
p14_INK4B
p15-INK4b
p15INK4B
p15INK4b
p15_INK4B
CDK inhibitory protein
CDK4B inhibitor
Multiple tumor suppressor 2
cyclin-dependent kinase 4 inhibitor B
cyclin-dependent kinase inhibitor 2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
cyclin-dependent kinases 4 and 6 binding protein
p14_CDK inhibitor
p15 CDK inhibitor

CDKN2B Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CDKN2B

Summariesfor CDKN2B

Genomic Locationfor CDKN2B

Proteinsfor CDKN2B

Protein Domains/Familiesfor CDKN2B

Gene Functionfor CDKN2B

Pathways & Interactionsfor CDKN2B

Drugs & Compoundsfor CDKN2B

Transcriptsfor CDKN2B

Expression for CDKN2B

Orthologsfor CDKN2B

Paralogsfor CDKN2B

SNPs/Variantsfor CDKN2B

Disorders & Mutationsfor CDKN2B

Medical Newsfor CDKN2B

Publicationsfor CDKN2B

Search for CDKN2B

Genome Databases showing CDKN2B

Other Databases showing CDKN2B

Specialized Databases showing CDKN2B

Licensable Technologiesfor CDKN2B

Servicesfor CDKN2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDKN2B

Summaries
for CDKN2B

Genomic Location
for CDKN2B

Proteins
for CDKN2B

Protein Domains/
Families
for CDKN2B

Gene Function
for CDKN2B

Pathways & Interactions
for CDKN2B

Drugs & Compounds
for CDKN2B

Transcripts
for CDKN2B

Expression
for CDKN2B

Orthologs
for CDKN2B

Paralogs
for CDKN2B

SNPs/Variants
for CDKN2B

Disorders & Mutations
for CDKN2B

Medical News
for CDKN2B

Publications
for CDKN2B

Licensable Technologies
for CDKN2B

Services
for CDKN2B