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CDKN2AIPNL Gene

protein-coding   GIFtS: 37
GCID: GC05M133756

CDKN2A Interacting Protein N-Terminal Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDKN2A Interacting Protein N-Terminal Like1 2
CDKN2A-Interacting Protein N-Terminal-Like Protein2 3
CDKN2AIP N-Terminal-Like Protein2

External Ids:    HGNC: 305451   Entrez Gene: 913682   Ensembl: ENSG000002371907   UniProtKB: Q96HQ23   

Export aliases for CDKN2AIPNL gene to outside databases

Previous GC identifer: GC05M128922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDKN2AIPNL Gene:
CDKN2AIPNL (CDKN2A interacting protein N-terminal like) is a protein-coding gene. An important paralog of this gene is CDKN2AIP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN2AIPNL gene promoter:
         AML1a   GCNF   Olf-1   Lmo2   FOXJ2 (long isoform)   GCNF-1   PPAR-gamma2   FOXJ2   GCNF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN2AIPNL promoter sequence
   Search Chromatin IP Primers for CDKN2AIPNL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN2AIPNL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

CDKN2AIPNL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN2AIPNL gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M133756:  view genomic region     (about GC identifiers)

Start:
133,737,756 bp from pter      End:
133,747,598 bp from pter
Size:
9,843 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: C2AIL_HUMAN, Q96HQ2 (See protein sequence)
Recommended Name: CDKN2AIP N-terminal-like protein  
Size: 116 amino acids; 13196 Da
Secondary accessions: Q8WVE3
Alternative splicing: 2 isoforms:  Q96HQ2-1   Q96HQ2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDKN2AIPNL: NX_Q96HQ2

Explore proteomics data for CDKN2AIPNL at MOPED


See CDKN2AIPNL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_542387.1  
ENSEMBL proteins: 
 ENSP00000394183   ENSP00000378456  

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antibodies-online kits for CDKN2AIPNL (8 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR021859 DUF3469

Graphical View of Domain Structure for InterPro Entry Q96HQ2

ProtoNet protein and cluster: Q96HQ2

UniProtKB/Swiss-Prot: C2AIL_HUMAN, Q96HQ2
Similarity: Belongs to the CARF family


Find genes that share domains with CDKN2AIPNL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 MGI phenotypic allele for Cdkn2aipnl (no phenotypes)

Find genes that share phenotypes with CDKN2AIPNL           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CDKN2AIPNL

miRNA
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miRTarBase miRNAs that target CDKN2AIPNL:
hsa-mir-92a-3p (MIRT049773)

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Selected qRT-PCR Assays for microRNAs that regulate CDKN2AIPNL (see all 11):
hsa-miR-130a* hsa-miR-4305 hsa-miR-23c hsa-miR-340 hsa-miR-583 hsa-miR-4294 hsa-miR-23b hsa-miR-558
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
mitochondrion1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDKN2AIPNL
Interactions:

    Search GeneGlobe Interaction Network for CDKN2AIPNL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CDKN2AIPNL (C2AIL)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CDKN2AIPNL gene: 
NM_080656.2  

Unigene Cluster for CDKN2AIPNL:

CDKN2A interacting protein N-terminal like
Hs.156506  [show with all ESTs]
Unigene Representative Sequence: NM_080656
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000458198(uc011cxs.2) ENST00000395009
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat CDKN2AIPNL

Additional mRNA sequence: 

AK057925.1 BC008293.1 BC018086.1 

6 DOTS entries:

DT.86846428  DT.202096  DT.97838822  DT.91713079  DT.95126629  DT.100712520 

Selected AceView cDNA sequences (see all 82):

AW590901 BU506898 AI261644 CR604625 BE396801 AK057925 BX336064 CR591520 
BU163724 BX335513 CR602620 AW439849 CR612048 CD722093 AI341611 AI377680 
BU621747 CR612735 BU159010 BQ670189 AI885154 BX096509 BX439619 BE855534 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CDKN2AIPNL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGGCGGACA
CDKN2AIPNL Expression
About this image

CDKN2AIPNL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CDKN2AIPNL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.156506
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2AIPNL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CDKN2AIPNL gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cdkn2aipnl1 , 5 CDKN2A interacting protein N-terminal like1, 5 89.08(n)1
96.55(a)1
  11 (31.78 cM)5
526261  NM_029976.31  NP_084252.11 
 519676615 
lizard
(Anolis carolinensis)
Reptilia CDKN2AIPNL6
CDKN2A interacting protein N-terminal like
65(a)
1 ↔ 1
2(130952241-130961927)
African clawed frog
(Xenopus laevis)
Amphibia Xl.271362 Xenopus laevis cDNA clone IMAGE6881328, partial cds 74.69(n)    BC053806.1 
zebrafish
(Danio rerio)
Actinopterygii cdkn2aipnl1 CDKN2A interacting protein N-terminal like 64.76(n)
53.33(a)
  450034  NM_001006055.1  NP_001006055.1 
fruit fly
(Drosophila melanogaster)
Insecta CG313016
--
5(a)
1 → many
3R(11171953-11173734)


ENSEMBL Gene Tree for CDKN2AIPNL (if available)
TreeFam Gene Tree for CDKN2AIPNL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CDKN2AIPNL gene
CDKN2AIP2  NKRF2  
1 SIMAP similar gene for CDKN2AIPNL using alignment to 1 protein entry:     C2AIL_HUMAN:
CDKN2AIP

Find genes that share paralogs with CDKN2AIPNL           About GenesLikeMe


3 Pseudogenes.org Pseudogenes for CDKN2AIPNL
PGOHUM00000248373 PGOHUM00000244458 PGOHUM00000240000


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CDKN2AIPNL (see all 189)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1846137941,2
--133737267(+) GAGAGC/GGGGTA 1 -- int10--------
rs3280421,2
C,F,H--133737275(+) GTACAG/TAACAG 1 -- int116Minor allele frequency- T:0.25MN NS EA NA 2176
rs1153813751,2
F--133737452(+) CTGACC/TGGACG 1 -- int11Minor allele frequency- T:0.01NA 120
rs1442289771,2
--133737462(+) GAAGCC/TCCGGA 1 -- int10--------
rs1487295191,2
--133737466(+) CCCCGA/GAATCC 1 -- int10--------
rs1889304291,2
--133737482(+) CAATTC/TGTTTT 1 -- int10--------
rs1438786261,2
C--133737609(+) TATGGC/TATAGG 1 -- int10--------
rs1817615841,2
--133737613(+) GTATAA/GGTATG 1 -- int10--------
rs1873157791,2
--133737759(+) TATTAC/TATCAA 1 -- ut310--------
rs1906146571,2
--133738061(+) GCTGGA/GATTAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for CDKN2AIPNL (133737756 - 133747598 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CDKN2AIPNL: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CDKN2AIPNL
DNA2.0 Custom Variant and Variant Library Synthesis for CDKN2AIPNL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CDKN2AIPNL gene integrated from 10 sources:
(articles sorted by number of sources associating them with CDKN2AIPNL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 91368 HGNC: 30545 AceView: MGC13017 Ensembl:ENSG00000237190 euGenes: HUgn91368
ECgene: CDKN2AIPNL H-InvDB: CDKN2AIPNL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CDKN2AIPNL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CDKN2AIPNL gene:
Search GeneIP for patents involving CDKN2AIPNL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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