CDKN2AIP Gene
protein-coding GIFtS: 45
GCID: GC04P184365
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CDKN2A interacting protein
| |
Aliases
for CDKN2AIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDKN2A Interacting Protein1 2 | | CARF1 2 3 | | Collaborator Of ARF2 3 | | FLJ200361 | | CDKN2A-Interacting Protein2 | | Collaborates/Cooperates With ARF (Alternate Reading Frame) Protein2 |
Export aliases for CDKN2AIP gene to outside databasesPrevious GC identifers: GC04P184603 GC04P180125 |
Summaries
for CDKN2AIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CARF_HUMAN, Q9NXV6Function: Activates p53/TP53 by CDKN2A-dependent and CDKN2A-independent pathways
|
Genomic Views
for CDKN2AIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDKN2AIP gene promoter:
GR AML1a GR-beta CUTL1 Tal-1beta POU3F2 E47 FOXJ2 (long isoform) GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDKN2AIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2AIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1CDKN2AIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P184365: view genomic region
(about GC identifiers)
Start:
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184,365,744 bp from pter |
End:
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184,369,351 bp from pter |
Size:
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3,608 bases |
Orientation:
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plus strand |
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Proteins
for CDKN2AIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CARF_HUMAN, Q9NXV6 (See
protein sequence)Recommended Name: CDKN2A-interacting protein Size: 580 amino acids; 61125 Da
Subunit: Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2
Subcellular location: Nucleus, nucleoplasm
Sequence caution: Sequence=AAF68967.1; Type=Frameshift; Positions=4;
Secondary accessions: Q8TBM5 Q9NYH0Explore the universe of human proteins at neXtProt for CDKN2AIP: NX_Q9NXV6
Post-translational modifications:
May be ubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXV6
CDKN2AIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060102.1
ENSEMBL proteins: ENSP00000427108 ENSP00000303788 ENSP00000421308
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CDKN2AIP for ontologies About GeneDecksing
CDKN2AIP Antibody Products:
Assay Products for CDKN2AIP: |
Protein
Domains /
Families
for CDKN2AIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDKN2AIP for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NXV6ProtoNet protein and cluster: Q9NXV6 UniProtKB/Swiss-Prot: CARF_HUMAN, Q9NXV6Similarity: Belongs to the CARF familySimilarity: Contains 1 DRBM (double-stranded RNA-binding) domain |
Function
for CDKN2AIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CARF_HUMAN, Q9NXV6Function: Activates p53/TP53 by CDKN2A-dependent and CDKN2A-independent pathways
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN2AIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN2AIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2AIP |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CDKN2AIP for ontologies About GeneDecksing
|
Pathways & Interactions
for CDKN2AIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN2AIP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/741 Interacting proteins for CDKN2AIP (Q9NXV62, 3 ENSP000003037884) via UniProtKB, MINT, STRING, and/or I2D (see all 741)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CDKN2AIP for ontologies About GeneDecksing
|
Drugs & Compounds
for CDKN2AIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDKN2AIP
Search CenterWatch for drugs/clinical trials and news about CDKN2AIP / CARF
|
Transcripts
for CDKN2AIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDKN2AIP gene: NM_017632.2 Unigene Cluster for CDKN2AIP: CDKN2A interacting protein Hs.644077 [show with all ESTs]Unigene Representative Sequence: AF2467055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504169(uc003ivp.1) ENST00000302350(uc003ivq.1) ENST00000510928
ENST00000506835 ENST00000502924
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN2AIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN2AIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDKN2AIP (NM_017632) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDKN2AIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2AIP |
Additional cDNA sequence: AF246705.1 AK000043.1 AK096180.1 AK225848.1 BC022270.1 BX538162.1 8 DOTS entries: DT.101982926 DT.444684 DT.102825022 DT.95165760 DT.121242685 DT.100772181 DT.91944931 DT.40294567 24/120 AceView cDNA sequences (see all 120): H85892 BG499946 AI521910 AL519574 BX423525 BQ549226 AA622329 AI954610 BU634171 BM461879 CB136069 AI769671 BM455747 BX394679 BF001809 CR623662 CB135399 NM_017632 AK000043 AI815643 BX096398 CB153556 AK096180 AA705963
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2AIP About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c |
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| SP1: | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDKN2AIP
|
Expression
for CDKN2AIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDKN2AIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTGGGTT
About this image
See CDKN2AIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDKN2AIP
SOURCE GeneReport for Unigene cluster: Hs.644077
UniProtKB/Swiss-Prot: CARF_HUMAN, Q9NXV6Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for CDKN2AIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDKN2AIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDKN2AIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2AIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2AIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2AIP |
Orthologs
for CDKN2AIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CDKN2AIP gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDKN2AIP1 |
CDKN2A interacting protein |
56.15(n)
49.82(a) |
|
769372 XM_003641181.1 XP_003641229.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CDKN2AIP6 |
-- |
45(a) |
1 ↔ 1 |
5(113826720-113831499) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC686902 |
hypothetical protein MGC68690 |
75.72(n) |
|
BC060029.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1016581 |
zgc:101658 |
52.25(n)
47.24(a) |
|
450065 NM_001006085.1 NP_001006085.1 |
ENSEMBL Gene Tree for CDKN2AIP (if available)
TreeFam Gene Tree for CDKN2AIP (if available) |
Paralogs
for CDKN2AIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDKN2AIP gene
- CDKN2AIPNL2 NKRF2
2 SIMAP similar genes for CDKN2AIP using alignment to 3 protein entries: CARF_HUMAN (see all proteins):DKFZp686M0665 CDKN2AIPNL
CDKN2AIP for paralogs About GeneDecksing
|
Genomic Variants
for CDKN2AIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDKN2AIP
1 CNV: 68862 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN2AIP |
|
Disorders
/ Diseases
for CDKN2AIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CDKN2AIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDKN2AIP gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with CDKN2AIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. (PubMed id 12154087)1, 2, 3 Hasan M.K.... Wadhwa R. (2002)
- CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor- suppressor pathway. (PubMed id 17460193)1, 2 Kamrul H.M.... Kaul S.C. (2007)
- CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints. (PubMed id 16803988)1, 3 Kaul S.C....Wadhwa R. (2006)
- Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. (PubMed id 15109303)1, 2 Hasan M.K....Kaul S.C. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A novel putative collaborator of p19ARF. (PubMed id 12581788)1, 2 Wadhwa R.... Kaul S.C. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Analysis of indel variations in the human disease-asso ciated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. (PubMed id 22552337)1 Kim R.N....Park H.S. (2012)
|
External Searches for CDKN2AIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDKN2AIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDKN2AIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDKN2AIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDKN2AIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDKN2AIP gene:
Search GeneIP for patents involving CDKN2AIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDKN2AIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDKN2AIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN2AIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN2AIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN2AIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKN2AIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKN2AIP |
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 | | | CDKN2AIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN2AIP |
|  |  |  | | | | Search ThermoFisher Antibodies for CDKN2AIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN2AIP |
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