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Aliases for CDKN2AIP Gene

Aliases for CDKN2AIP Gene

  • CDKN2A Interacting Protein 2 3
  • Collaborates/Cooperates With ARF (Alternate Reading Frame) Protein 2 3
  • Collaborator Of ARF 3 4
  • CARF 3 4
  • CDKN2A-Interacting Protein 3

External Ids for CDKN2AIP Gene

Summaries for CDKN2AIP Gene

GeneCards Summary for CDKN2AIP Gene

CDKN2AIP (CDKN2A Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include RNA binding and p53 binding. An important paralog of this gene is CDKN2AIPNL.

UniProtKB/Swiss-Prot for CDKN2AIP Gene

  • Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2AIP Gene

Genomics for CDKN2AIP Gene

Genomic Location for CDKN2AIP Gene

Start:
183,444,591 bp from pter
End:
183,448,198 bp from pter
Size:
3,608 bases
Orientation:
Plus strand

Genomic View for CDKN2AIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2AIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2AIP Gene

Regulatory Elements for CDKN2AIP Gene

Proteins for CDKN2AIP Gene

  • Protein details for CDKN2AIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXV6-CARF_HUMAN
    Recommended name:
    CDKN2A-interacting protein
    Protein Accession:
    Q9NXV6
    Secondary Accessions:
    • Q8TBM5
    • Q9NYH0

    Protein attributes for CDKN2AIP Gene

    Size:
    580 amino acids
    Molecular mass:
    61125 Da
    Quaternary structure:
    • Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3.
    SequenceCaution:
    • Sequence=AAF68967.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

neXtProt entry for CDKN2AIP Gene

Proteomics data for CDKN2AIP Gene at MOPED

Post-translational modifications for CDKN2AIP Gene

Other Protein References for CDKN2AIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDKN2AIP Gene

Domains for CDKN2AIP Gene

Protein Domains for CDKN2AIP Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CARF_HUMAN
Domain:
  • Contains 1 DRBM (double-stranded RNA-binding) domain.:
    • Q9NXV6
Family:
  • Belongs to the CARF family.:
    • Q9NXV6
genes like me logo Genes that share domains with CDKN2AIP: view

No data available for Gene Families for CDKN2AIP Gene

Function for CDKN2AIP Gene

Molecular function for CDKN2AIP Gene

UniProtKB/Swiss-Prot Function: Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
UniProtKB/Swiss-Prot Induction: Up-regulated during replicative senescence, in response to DNA-damaging drugs, telomere unprotection and oncogenic Ras-induced stress. Induced by proteasomal inhibitor MG132. Up-regulated at G1 and G2 stages of cell cycle.

Gene Ontology (GO) - Molecular Function for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 15109303
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 12581788
genes like me logo Genes that share ontologies with CDKN2AIP: view

miRNA for CDKN2AIP Gene

miRTarBase miRNAs that target CDKN2AIP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDKN2AIP Gene

Localization for CDKN2AIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2AIP Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2AIP Gene COMPARTMENTS Subcellular localization image for CDKN2AIP gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001652 granular component IDA 12154087
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 12154087
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDKN2AIP: view

Pathways for CDKN2AIP Gene

SuperPathways for CDKN2AIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 24825908
GO:0009967 positive regulation of signal transduction IMP 15109303
GO:0030307 positive regulation of cell growth IMP 24825908
GO:0030308 negative regulation of cell growth IMP 12154087
GO:0031647 regulation of protein stability IMP 12154087
genes like me logo Genes that share ontologies with CDKN2AIP: view

No data available for Pathways by source for CDKN2AIP Gene

Transcripts for CDKN2AIP Gene

Unigene Clusters for CDKN2AIP Gene

CDKN2A interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2AIP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for CDKN2AIP Gene

GeneLoc Exon Structure for
CDKN2AIP
ECgene alternative splicing isoforms for
CDKN2AIP

Expression for CDKN2AIP Gene

mRNA expression in normal human tissues for CDKN2AIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDKN2AIP Gene

SOURCE GeneReport for Unigene cluster for CDKN2AIP Gene Hs.644077

mRNA Expression by UniProt/SwissProt for CDKN2AIP Gene

Q9NXV6-CARF_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with CDKN2AIP: view

Orthologs for CDKN2AIP Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKN2AIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN2AIP 36
  • 99.77 (n)
  • 100 (a)
CDKN2AIP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN2AIP 36
  • 88.14 (n)
  • 89.58 (a)
CDKN2AIP 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2AIP 36
  • 91.26 (n)
  • 92.36 (a)
CDKN2AIP 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkn2aip 36
  • 85.13 (n)
  • 86.74 (a)
Cdkn2aip 16
Cdkn2aip 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDKN2AIP 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkn2aip 36
  • 87.57 (n)
  • 88.34 (a)
chicken
(Gallus gallus)
Aves CDKN2AIP 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN2AIP 37
  • 44 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68690 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2aip 36
  • 65.94 (n)
  • 66.87 (a)
Str.7491 36
zebrafish
(Danio rerio)
Actinopterygii cdkn2aip 36
  • 56.98 (n)
  • 54.65 (a)
cdkn2aip 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31301 37
  • 13 (a)
OneToMany
Species with no ortholog for CDKN2AIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2AIP Gene

ENSEMBL:
Gene Tree for CDKN2AIP (if available)
TreeFam:
Gene Tree for CDKN2AIP (if available)

Paralogs for CDKN2AIP Gene

Paralogs for CDKN2AIP Gene

Selected SIMAP similar genes for CDKN2AIP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDKN2AIP: view

Variants for CDKN2AIP Gene

Sequence variations from dbSNP and Humsavar for CDKN2AIP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3187025 -- 183,447,887(+) TGAAC(A/G)TGTCT utr-variant-3-prime
rs4241768 -- 183,442,734(+) TAATT(A/T)AAAAA upstream-variant-2KB
rs4241769 -- 183,443,205(+) CTTGC(C/T)ATGGT upstream-variant-2KB
rs4241770 -- 183,443,214(+) GTCCC(C/G)TTGCC upstream-variant-2KB
rs4241771 -- 183,443,448(+) TAGCT(A/G)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDKN2AIP Gene

Variant ID Type Subtype PubMed ID
esv26305 CNV Gain 19812545

Relevant External Links for CDKN2AIP Gene

HapMap Linkage Disequilibrium report
CDKN2AIP

Disorders for CDKN2AIP Gene

No disorders were found for CDKN2AIP Gene.

No data available for UniProtKB/Swiss-Prot for CDKN2AIP Gene

Publications for CDKN2AIP Gene

  1. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. (PMID: 12154087) Hasan M.K. … Wadhwa R. (J. Biol. Chem. 2002) 2 3 4
  2. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. (PMID: 24825908) Cheung C.T. … Wadhwa R. (J. Biol. Chem. 2014) 3 4
  3. A novel putative collaborator of p19ARF. (PMID: 12581788) Wadhwa R. … Kaul S.C. (Exp. Gerontol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. (PMID: 15109303) Hasan M.K. … Kaul S.C. (Biochem. J. 2004) 3 4

Products for CDKN2AIP Gene

Sources for CDKN2AIP Gene

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