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Aliases for CDKN2AIP Gene

Aliases for CDKN2AIP Gene

  • CDKN2A Interacting Protein 2 3 5
  • Collaborates/Cooperates With ARF (Alternate Reading Frame) Protein 2 3
  • Collaborator Of ARF 3 4
  • CaRF 3 4
  • CDKN2A-Interacting Protein 3

External Ids for CDKN2AIP Gene

Previous GeneCards Identifiers for CDKN2AIP Gene

  • GC04P184603
  • GC04P184365
  • GC04P180125

Summaries for CDKN2AIP Gene

Entrez Gene Summary for CDKN2AIP Gene

  • The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDKN2AIP Gene

CDKN2AIP (CDKN2A Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include RNA binding and p53 binding. An important paralog of this gene is NKRF.

UniProtKB/Swiss-Prot for CDKN2AIP Gene

  • Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2AIP Gene

Genomics for CDKN2AIP Gene

Regulatory Elements for CDKN2AIP Gene

Enhancers for CDKN2AIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G182915 1.1 ENCODE 28.8 -526.7 -526671 3.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CDKN2AIP DCTD ENSG00000272646
GH04G183442 1.1 ENCODE 26.6 -0.1 -79 3.8 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 MLX ZFP64 SIN3A ARID4B DMAP1 CDKN2AIP RWDD4 TRAPPC11 LOC100127981
GH04G184280 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +837.9 837857 4.5 HDGF FOXA2 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 FEZF1 PRIMPOL MYL12BP2 CDKN2AIP ENSG00000251878 RNU6-1053P LINC02363 ENPP6 CENPU CASP3 IRF2
GH04G183406 1.6 FANTOM5 Ensembl ENCODE 15.3 -35.1 -35131 5.5 HDGF PKNOX1 FOXA2 ARNT SIN3A YBX1 YY1 CBX5 ZNF143 JUNB CDKN2AIP LOC100127981 LOC100533630
GH04G184353 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +911.5 911499 4.6 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 LINC02363 IRF2 PRIMPOL CDKN2AIP ENSG00000251878 CFAP97 ACSL1 ENSG00000248206 LINC02362
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDKN2AIP on UCSC Golden Path with GeneCards custom track

Promoters for CDKN2AIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176814 109 2601 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for CDKN2AIP Gene

Chromosome:
4
Start:
183,444,591 bp from pter
End:
183,449,064 bp from pter
Size:
4,474 bases
Orientation:
Plus strand

Genomic View for CDKN2AIP Gene

Genes around CDKN2AIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2AIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2AIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2AIP Gene

Proteins for CDKN2AIP Gene

  • Protein details for CDKN2AIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXV6-CARF_HUMAN
    Recommended name:
    CDKN2A-interacting protein
    Protein Accession:
    Q9NXV6
    Secondary Accessions:
    • Q8TBM5
    • Q9NYH0

    Protein attributes for CDKN2AIP Gene

    Size:
    580 amino acids
    Molecular mass:
    61125 Da
    Quaternary structure:
    • Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3. Interacts with XRN2 (PubMed:24462208).
    SequenceCaution:
    • Sequence=AAF68967.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

neXtProt entry for CDKN2AIP Gene

Post-translational modifications for CDKN2AIP Gene

Other Protein References for CDKN2AIP Gene

No data available for DME Specific Peptides for CDKN2AIP Gene

Domains & Families for CDKN2AIP Gene

Protein Domains for CDKN2AIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDKN2AIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXV6

UniProtKB/Swiss-Prot:

CARF_HUMAN :
  • Belongs to the CARF family.
Family:
  • Belongs to the CARF family.
genes like me logo Genes that share domains with CDKN2AIP: view

No data available for Gene Families for CDKN2AIP Gene

Function for CDKN2AIP Gene

Molecular function for CDKN2AIP Gene

UniProtKB/Swiss-Prot Function:
Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
UniProtKB/Swiss-Prot Induction:
Up-regulated during replicative senescence, in response to DNA-damaging drugs, telomere unprotection and oncogenic Ras-induced stress. Induced by proteasomal inhibitor MG132. Up-regulated at G1 and G2 stages of cell cycle.

Gene Ontology (GO) - Molecular Function for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 15109303
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 12581788
genes like me logo Genes that share ontologies with CDKN2AIP: view
genes like me logo Genes that share phenotypes with CDKN2AIP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDKN2AIP Gene

Localization for CDKN2AIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2AIP Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKN2AIP gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001652 granular component IDA 12154087
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 12154087
GO:0005730 nucleolus IDA 12154087
genes like me logo Genes that share ontologies with CDKN2AIP: view

Pathways & Interactions for CDKN2AIP Gene

SuperPathways for CDKN2AIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 24825908
GO:0009967 positive regulation of signal transduction IMP 15109303
GO:0030307 positive regulation of cell growth IMP 24825908
GO:0030308 negative regulation of cell growth IMP 12154087
GO:0031647 regulation of protein stability IMP 12154087
genes like me logo Genes that share ontologies with CDKN2AIP: view

No data available for Pathways by source and SIGNOR curated interactions for CDKN2AIP Gene

Drugs & Compounds for CDKN2AIP Gene

No Compound Related Data Available

Transcripts for CDKN2AIP Gene

Unigene Clusters for CDKN2AIP Gene

CDKN2A interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2AIP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for CDKN2AIP Gene

GeneLoc Exon Structure for
CDKN2AIP
ECgene alternative splicing isoforms for
CDKN2AIP

Expression for CDKN2AIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDKN2AIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDKN2AIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6) and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDKN2AIP Gene



Protein tissue co-expression partners for CDKN2AIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDKN2AIP Gene:

CDKN2AIP

SOURCE GeneReport for Unigene cluster for CDKN2AIP Gene:

Hs.644077

mRNA Expression by UniProt/SwissProt for CDKN2AIP Gene:

Q9NXV6-CARF_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for CDKN2AIP Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with CDKN2AIP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKN2AIP Gene

Orthologs for CDKN2AIP Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKN2AIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN2AIP 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia CDKN2AIP 34 35
  • 91.26 (n)
cow
(Bos Taurus)
Mammalia CDKN2AIP 34 35
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Cdkn2aip 34
  • 87.57 (n)
mouse
(Mus musculus)
Mammalia Cdkn2aip 34 16 35
  • 85.13 (n)
oppossum
(Monodelphis domestica)
Mammalia CDKN2AIP 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDKN2AIP 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN2AIP 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2aip 34
  • 65.94 (n)
Str.7491 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68690 34
zebrafish
(Danio rerio)
Actinopterygii cdkn2aip 34 35
  • 56.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31301 35
  • 13 (a)
OneToMany
Species where no ortholog for CDKN2AIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2AIP Gene

ENSEMBL:
Gene Tree for CDKN2AIP (if available)
TreeFam:
Gene Tree for CDKN2AIP (if available)

Paralogs for CDKN2AIP Gene

Paralogs for CDKN2AIP Gene

(2) SIMAP similar genes for CDKN2AIP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDKN2AIP: view

Variants for CDKN2AIP Gene

Sequence variations from dbSNP and Humsavar for CDKN2AIP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs193921061 Uncertain significance 183,446,598(+) GCCAC(G/T)ATTGT reference, missense, utr-variant-3-prime
rs1000801073 -- 183,445,202(+) CCCGG(A/C)TGCCC intron-variant
rs1000956513 -- 183,445,483(+) CACAA(A/G)TAGGA intron-variant
rs1001196996 -- 183,443,579(+) AAAAA(G/T)TTCAT upstream-variant-2KB
rs1001628424 -- 183,443,732(+) TAACA(A/G)GGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDKN2AIP Gene

Variant ID Type Subtype PubMed ID
esv26305 CNV gain 19812545
nsv1030766 CNV gain 25217958
nsv1033995 CNV gain 25217958

Variation tolerance for CDKN2AIP Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.22; 94.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKN2AIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDKN2AIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKN2AIP Gene

Disorders for CDKN2AIP Gene

Relevant External Links for CDKN2AIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDKN2AIP

No disorders were found for CDKN2AIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDKN2AIP Gene

Publications for CDKN2AIP Gene

  1. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. (PMID: 12154087) Hasan M.K. … Wadhwa R. (J. Biol. Chem. 2002) 2 3 4 64
  2. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. (PMID: 24825908) Cheung C.T. … Wadhwa R. (J. Biol. Chem. 2014) 3 4 64
  3. Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. (PMID: 24485912) Singh R. … Wadhwa R. (Exp. Cell Res. 2014) 3 4 64
  4. CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor- suppressor pathway. (PMID: 17460193) Kamrul H.M. … Kaul S.C. (Ann. N. Y. Acad. Sci. 2007) 3 4 64
  5. CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints. (PMID: 16803988) Kaul S.C. … Wadhwa R. (Ann. N. Y. Acad. Sci. 2006) 2 3 64

Products for CDKN2AIP Gene

Sources for CDKN2AIP Gene

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