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Aliases for CDKN2AIP Gene

Aliases for CDKN2AIP Gene

  • CDKN2A Interacting Protein 2 3 5
  • Collaborates/Cooperates With ARF (Alternate Reading Frame) Protein 2 3
  • Collaborator Of ARF 3 4
  • CaRF 3 4

External Ids for CDKN2AIP Gene

Previous GeneCards Identifiers for CDKN2AIP Gene

  • GC04P184603
  • GC04P184365
  • GC04P180125

Summaries for CDKN2AIP Gene

Entrez Gene Summary for CDKN2AIP Gene

  • The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDKN2AIP Gene

CDKN2AIP (CDKN2A Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include RNA binding and p53 binding. An important paralog of this gene is CDKN2AIPNL.

UniProtKB/Swiss-Prot for CDKN2AIP Gene

  • Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2AIP Gene

Genomics for CDKN2AIP Gene

Regulatory Elements for CDKN2AIP Gene

Enhancers for CDKN2AIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDKN2AIP on UCSC Golden Path with GeneCards custom track

Promoters for CDKN2AIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDKN2AIP on UCSC Golden Path with GeneCards custom track

Genomic Location for CDKN2AIP Gene

183,444,591 bp from pter
183,449,064 bp from pter
4,474 bases
Plus strand

Genomic View for CDKN2AIP Gene

Genes around CDKN2AIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2AIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2AIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2AIP Gene

Proteins for CDKN2AIP Gene

  • Protein details for CDKN2AIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CDKN2A-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q8TBM5
    • Q9NYH0

    Protein attributes for CDKN2AIP Gene

    580 amino acids
    Molecular mass:
    61125 Da
    Quaternary structure:
    • Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3.
    • Sequence=AAF68967.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

neXtProt entry for CDKN2AIP Gene

Proteomics data for CDKN2AIP Gene at MOPED

Post-translational modifications for CDKN2AIP Gene

Other Protein References for CDKN2AIP Gene

Antibody Products

No data available for DME Specific Peptides for CDKN2AIP Gene

Domains & Families for CDKN2AIP Gene

Protein Domains for CDKN2AIP Gene


Suggested Antigen Peptide Sequences for CDKN2AIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Belongs to the CARF family.
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Belongs to the CARF family.
genes like me logo Genes that share domains with CDKN2AIP: view

No data available for Gene Families for CDKN2AIP Gene

Function for CDKN2AIP Gene

Molecular function for CDKN2AIP Gene

UniProtKB/Swiss-Prot Function:
Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
UniProtKB/Swiss-Prot Induction:
Up-regulated during replicative senescence, in response to DNA-damaging drugs, telomere unprotection and oncogenic Ras-induced stress. Induced by proteasomal inhibitor MG132. Up-regulated at G1 and G2 stages of cell cycle.
genes like me logo Genes that share phenotypes with CDKN2AIP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDKN2AIP Gene

Localization for CDKN2AIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2AIP Gene

Nucleus, nucleoplasm.

Subcellular locations from

Jensen Localization Image for CDKN2AIP Gene COMPARTMENTS Subcellular localization image for CDKN2AIP gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for CDKN2AIP Gene

Pathways & Interactions for CDKN2AIP Gene

SuperPathways for CDKN2AIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKN2AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 24825908
genes like me logo Genes that share ontologies with CDKN2AIP: view

No data available for Pathways by source and SIGNOR curated interactions for CDKN2AIP Gene

Drugs & Compounds for CDKN2AIP Gene

No Compound Related Data Available

Transcripts for CDKN2AIP Gene

Unigene Clusters for CDKN2AIP Gene

CDKN2A interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2AIP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for CDKN2AIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKN2AIP Gene

mRNA expression in normal human tissues for CDKN2AIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDKN2AIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6) and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKN2AIP Gene

SOURCE GeneReport for Unigene cluster for CDKN2AIP Gene Hs.644077

mRNA Expression by UniProt/SwissProt for CDKN2AIP Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CDKN2AIP: view

Protein tissue co-expression partners for CDKN2AIP Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CDKN2AIP Gene

Orthologs for CDKN2AIP Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKN2AIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDKN2AIP 35
  • 88.14 (n)
  • 89.58 (a)
  • 93 (a)
(Canis familiaris)
Mammalia CDKN2AIP 35
  • 91.26 (n)
  • 92.36 (a)
  • 91 (a)
(Mus musculus)
Mammalia Cdkn2aip 35
  • 85.13 (n)
  • 86.74 (a)
Cdkn2aip 16
Cdkn2aip 36
  • 84 (a)
(Pan troglodytes)
Mammalia CDKN2AIP 35
  • 99.77 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdkn2aip 35
  • 87.57 (n)
  • 88.34 (a)
(Monodelphis domestica)
Mammalia CDKN2AIP 36
  • 61 (a)
(Gallus gallus)
Aves CDKN2AIP 36
  • 45 (a)
(Anolis carolinensis)
Reptilia CDKN2AIP 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2aip 35
  • 65.94 (n)
  • 66.87 (a)
Str.7491 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68690 35
(Danio rerio)
Actinopterygii cdkn2aip 35
  • 56.98 (n)
  • 54.65 (a)
cdkn2aip 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31301 36
  • 13 (a)
Species with no ortholog for CDKN2AIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2AIP Gene

Gene Tree for CDKN2AIP (if available)
Gene Tree for CDKN2AIP (if available)

Paralogs for CDKN2AIP Gene

Paralogs for CDKN2AIP Gene

(2) SIMAP similar genes for CDKN2AIP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDKN2AIP: view

Variants for CDKN2AIP Gene

Sequence variations from dbSNP and Humsavar for CDKN2AIP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1133036 -- 183,448,808(+) ATAAT(C/T)AGATG utr-variant-3-prime
rs4241768 -- 183,442,734(+) TAATT(A/T)AAAAA upstream-variant-2KB
rs4241769 -- 183,443,205(+) CTTGC(C/T)ATGGT upstream-variant-2KB
rs4241770 -- 183,443,214(+) GTCCC(C/G)TTGCC upstream-variant-2KB
rs4241771 -- 183,443,448(+) TAGCT(A/G)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDKN2AIP Gene

Variant ID Type Subtype PubMed ID
esv26305 CNV Gain 19812545

Variation tolerance for CDKN2AIP Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.22; 94.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDKN2AIP Gene

Disorders for CDKN2AIP Gene

Relevant External Links for CDKN2AIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDKN2AIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDKN2AIP Gene

Publications for CDKN2AIP Gene

  1. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. (PMID: 12154087) Hasan M.K. … Wadhwa R. (J. Biol. Chem. 2002) 2 3 4 67
  2. CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints. (PMID: 16803988) Kaul S.C. … Wadhwa R. (Ann. N. Y. Acad. Sci. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CDKN2AIP Gene

Sources for CDKN2AIP Gene