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Aliases for CDKN2A Gene

Aliases for CDKN2A Gene

  • Cyclin-Dependent Kinase Inhibitor 2A 2 3 4
  • MTS1 3 4 6
  • MLM 3 4 6
  • Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) 2 3
  • Cyclin-Dependent Kinase 4 Inhibitor A 3 4
  • Multiple Tumor Suppressor 1 3 4
  • P16-INK4A 3 4
  • P16INK4A 3 4
  • P14ARF 3 4
  • CDK4I 3 4
  • CDKN2 3 4
  • MTS-1 3 4
  • CMM2 3 6
  • P16 3 6
  • ARF 3 4
  • Cell Cycle Negative Regulator Beta 3
  • Alternative Reading Frame 4
  • CDK4 Inhibitor P16-INK4 3
  • P16-INK4 4
  • P16INK4 3
  • P19ARF 3
  • INK4A 3
  • INK4 3
  • TP16 3
  • P19 3
  • P14 3

External Ids for CDKN2A Gene

Previous Symbols for CDKN2A Gene

  • CDKN2
  • MLM

Summaries for CDKN2A Gene

Entrez Gene Summary for CDKN2A Gene

  • This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for CDKN2A Gene

CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A) is a Protein Coding gene. Diseases associated with CDKN2A include anthracosis and gallbladder adenoma. Among its related pathways are Glioma and Pathways in cancer. GO annotations related to this gene include protein kinase binding and p53 binding. An important paralog of this gene is CDKN2B.

UniProtKB/Swiss-Prot for CDKN2A Gene

  • Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its Lys63-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.

  • Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Gene Wiki entry for CDKN2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2A Gene

Genomics for CDKN2A Gene

Genomic Location for CDKN2A Gene

Start:
21,967,752 bp from pter
End:
21,995,301 bp from pter
Size:
27,550 bases
Orientation:
Minus strand

Genomic View for CDKN2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2A Gene

Regulatory Elements for CDKN2A Gene

Transcription factor binding sites by QIAGEN in the CDKN2A gene promoter:

Proteins for CDKN2A Gene

  • Protein details for CDKN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42771-CDN2A_HUMAN
    Recommended name:
    Cyclin-dependent kinase inhibitor 2A
    Protein Accession:
    P42771
    Secondary Accessions:
    • A5X2G7
    • D3DRK1
    • O95440
    • Q15191
    • Q5VVJ5
    • Q96B52
    • Q9NP05

    Protein attributes for CDKN2A Gene

    Size:
    156 amino acids
    Molecular mass:
    16533 Da
    Quaternary structure:
    • Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both T-172-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.
    SequenceCaution:
    • Sequence=AAB60645.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDKN2A Gene

    Alternative splice isoforms for CDKN2A Gene

  • Protein details for CDKN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N726-ARF_HUMAN
    Recommended name:
    Tumor suppressor ARF
    Protein Accession:
    Q8N726
    Secondary Accessions:
    • D3DRK2
    • Q13195
    • Q13399
    • Q16360
    • Q7KZR9

    Protein attributes for CDKN2A Gene

    Size:
    132 amino acids
    Molecular mass:
    13903 Da
    Quaternary structure:
    • Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Isoform smARF interacts with C1QBP.
    SequenceCaution:
    • Sequence=AAB01737.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC60649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH15960.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH21998.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAM77919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH70601.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW58600.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW58601.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDKN2A Gene

neXtProt entry for CDKN2A Gene

Proteomics data for CDKN2A Gene at MOPED

Post-translational modifications for CDKN2A Gene

  • Phosphorylation seems to increase interaction with CDK4.
  • Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardeless of the absence of lysine residues. Ubiquitination leads to its degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDKN2A Gene

Domains for CDKN2A Gene

Protein Domains for CDKN2A Gene

UniProtKB/Swiss-Prot:

ARF_HUMAN
Family:
  • Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.:
    • P42771
Similarity:
  • Contains 4 ANK repeats.:
    • P42771
genes like me logo Genes that share domains with CDKN2A: view

No data available for Gene Families for CDKN2A Gene

Function for CDKN2A Gene

Molecular function for CDKN2A Gene

GENATLAS Biochemistry: cyclin dependent kinases 4 and 6 (CDK4/CDK6) inhibitor p16 (p16INK4A),blocking them from phosphorylating RB1 and preventing exit from G1 phase of the cell cycle, encoding for an alternative reading frame p14ARF,homolog to murine p19ARF,putatively inducing G1 and G2 phase arrest,inactivated (LOH) in preneoplastic pancreatic duct lesions in head and neck cancer in progression and inactivated by hypermethylation in childhood lymphoblastic leukemia (see TSG9A)
UniProtKB/Swiss-Prot Function: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its Lys63-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.
UniProtKB/Swiss-Prot Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Gene Ontology (GO) - Molecular Function for CDKN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 9529249
GO:0003677 DNA binding IEA --
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 8259215
GO:0005515 protein binding IPI 11278317
GO:0008134 transcription factor binding IPI 19057511
genes like me logo Genes that share ontologies with CDKN2A: view
genes like me logo Genes that share phenotypes with CDKN2A: view

Animal Models for CDKN2A Gene

MGI Knock Outs for CDKN2A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDKN2A Gene

Localization for CDKN2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN2A Gene

Cytoplasm. Nucleus.
Nucleus, nucleolus. Nucleus, nucleoplasm.
Isoform smARF: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN2A Gene COMPARTMENTS Subcellular localization image for CDKN2A gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
extracellular 3
golgi apparatus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
plasma membrane 2
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDKN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16243918
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 16243918
GO:0005739 mitochondrion IMP 25217637
genes like me logo Genes that share ontologies with CDKN2A: view

Pathways for CDKN2A Gene

genes like me logo Genes that share pathways with CDKN2A: view

Gene Ontology (GO) - Biological Process for CDKN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 10208428
GO:0000209 protein polyubiquitination IDA 18305112
GO:0000278 mitotic cell cycle TAS --
GO:0000422 mitochondrion degradation IMP 25217637
GO:0001953 negative regulation of cell-matrix adhesion IMP 10205165
genes like me logo Genes that share ontologies with CDKN2A: view

Compounds for CDKN2A Gene

(119) Novoseek inferred chemical compound relationships for CDKN2A Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 76.1 60
5-methylthioadenosine 70.2 20
mtsi 67.9 3
sodium bisulfite 60.7 9
crcs 57.1 15
genes like me logo Genes that share compounds with CDKN2A: view

Transcripts for CDKN2A Gene

Unigene Clusters for CDKN2A Gene

Cyclin-dependent kinase inhibitor 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: -
SP6: - - - - - - - - -
SP7: -
SP8: -

Relevant External Links for CDKN2A Gene

GeneLoc Exon Structure for
CDKN2A
ECgene alternative splicing isoforms for
CDKN2A

Expression for CDKN2A Gene

mRNA expression in normal human tissues for CDKN2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDKN2A Gene

This gene is overexpressed in Pituitary (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDKN2A Gene

SOURCE GeneReport for Unigene cluster for CDKN2A Gene Hs.512599

mRNA Expression by UniProt/SwissProt for CDKN2A Gene

P42771-CDN2A_HUMAN
Tissue specificity: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
genes like me logo Genes that share expressions with CDKN2A: view

Orthologs for CDKN2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN2A 36
  • 99.15 (n)
  • 99.36 (a)
CDKN2A 37
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN2A 36
  • 85.04 (n)
  • 82.05 (a)
CDKN2A 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2A 36
  • 86.67 (n)
  • 82.86 (a)
mouse
(Mus musculus)
Mammalia Cdkn2a 36
  • 75.47 (n)
  • 74.4 (a)
Cdkn2a 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 57 (a)
ManyToMany
CDKN2A 37
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cdkn2a 36
  • 76.96 (n)
  • 78.05 (a)
chicken
(Gallus gallus)
Aves CDKN2B 37
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2b 36
  • 56.06 (n)
  • 57.27 (a)
zebrafish
(Danio rerio)
Actinopterygii BX323448.2 37
  • 45 (a)
ManyToMany
LOC100329528 36
  • 52.26 (n)
  • 47.46 (a)
Species with no ortholog for CDKN2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2A Gene

ENSEMBL:
Gene Tree for CDKN2A (if available)
TreeFam:
Gene Tree for CDKN2A (if available)

Paralogs for CDKN2A Gene

Paralogs for CDKN2A Gene

genes like me logo Genes that share paralogs with CDKN2A: view

Variants for CDKN2A Gene

Sequence variations from dbSNP and Humsavar for CDKN2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1800586 Pathogenic 21,974,861(-) GGAGA(C/G/T)GGGGA utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs2255962 -- 21,969,828(+) GAGGG(A/G)CCGAG intron-variant
rs2518719 -- 21,970,428(+) TGCAG(A/G)AGAGC intron-variant
rs2518720 -- 21,978,980(+) TGTAA(C/T)GCTCT intron-variant
rs2518721 -- 21,979,205(+) AAAGT(A/G)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN2A Gene

Variant ID Type Subtype PubMed ID
nsv8426 CNV Loss 18304495
nsv892745 CNV Gain 21882294
nsv892746 CNV Loss 21882294
esv1425040 CNV Deletion 17803354
nsv892747 CNV Gain 21882294

Relevant External Links for CDKN2A Gene

HapMap Linkage Disequilibrium report
CDKN2A
Human Gene Mutation Database (HGMD)
CDKN2A
Locus Specific Mutation Databases (LSDB)
CDKN2A

Disorders for CDKN2A Gene

(3) OMIM Diseases for CDKN2A Gene (600160)

UniProtKB/Swiss-Prot

ARF_HUMAN
  • Note=The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients.
  • Melanoma, cutaneous malignant 2 (CMM2) [MIM:155601]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:10651484, ECO:0000269 PubMed:10874641, ECO:0000269 PubMed:11506491, ECO:0000269 PubMed:12019208, ECO:0000269 PubMed:14646619, ECO:0000269 PubMed:19260062, ECO:0000269 PubMed:7987387, ECO:0000269 PubMed:8595405, ECO:0000269 PubMed:8653684, ECO:0000269 PubMed:8710906, ECO:0000269 PubMed:9328469, ECO:0000269 PubMed:9425228}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome (FAMMMPC) [MIM:606719]: An inherited cancer predisposition syndrome characterized by an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Li-Fraumeni syndrome (LFS) [MIM:151623]: Autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers. {ECO:0000269 PubMed:10484981}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Melanoma-astrocytoma syndrome (MASTS) [MIM:155755]: Characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. {ECO:0000269 PubMed:11136714}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for CDKN2A Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 88.2 151
tumors 85.7 447
melanoma 79.4 455
carcinoma squamous cell 79 232
microsatellite instability 78.5 37

Relevant External Links for CDKN2A

Genetic Association Database (GAD)
CDKN2A
Human Genome Epidemiology (HuGE) Navigator
CDKN2A
genes like me logo Genes that share disorders with CDKN2A: view

Publications for CDKN2A Gene

  1. Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. (PMID: 12556369) Hearle N. … Houlston R.S. (Invest. Ophthalmol. Vis. Sci. 2003) 3 4 23 49
  2. An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. (PMID: 12406345) Bertram C.G. … Newton Bishop J.A. (J. Invest. Dermatol. 2002) 3 23 49
  3. The CDKN2A tumour suppressor gene: no mutations detected in patients with melanoma and additional unrelated cancers. (PMID: 12459645) Alao J.P. … Retsas S. (Melanoma Res. 2002) 3 23 49
  4. Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene. (PMID: 12532425) Sakano S. … Larsson P. (Int. J. Cancer 2003) 3 23 49
  5. Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families. (PMID: 11008905) Goldstein A.M. … Demenais F. (Cancer Epidemiol. Biomarkers Prev. 2000) 3 23 49

Products for CDKN2A Gene

Sources for CDKN2A Gene

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