Aliases for CDKN1C Gene
External Ids for CDKN1C Gene
Previous Symbols for CDKN1C Gene
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for CDKN1C Gene
CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (P57, Kip2)) is a Protein Coding gene. Diseases associated with CDKN1C include beckwith-wiedemann syndrome due to cdkn1c mutation and image syndrome. Among its related pathways are Endochondral Ossification and Cell Cycle / Checkpoint Control. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN1A.
UniProtKB/Swiss-Prot for CDKN1C Gene
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life