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CDKN1C Gene

protein-coding   GIFtS: 68

GC11M002861
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
(Previous name: Beckwith-Wiedemann syndrome )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: BWCR, BWS)
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Aliases &
Descriptions
for CDKN1C

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BWCR 2
BWS 2, 5
KIP2 1, 2, 3, 5
OTTHUMP00000011736 2
P57 1
WBS 2
p57 2
p57KIP2 3
Descriptions
Beckwith-Wiedemann syndrome 1
Cyclin-dependent kinase inhibitor p57 3
cyclin-dependent kinase inhibitor 1C 2
cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2
External Ids
HGNC: 17861
Entrez Gene: 10282
UniProtKB: P499183
Ensembl: ENSG000001297577
Search outside databases for aliases for CDKN1C gene

Previous GC identifers: GC11M003372 GC11M003107 GC11M002863 GC11M002869 GC11M002852

Summaries
for CDKN1C

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for CDKN1C:
The protein encoded by this gene is a tight-binding, strong inhibitor of several G1 cyclin/Cdk
complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in
sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor
candidate. Three transcript variants encoding two different isoforms have been found for this
gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDN1C_HUMAN, P49918
Function: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin
D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative
regulator of cell proliferation. May play a role in maintenance of the non-proliferative state
throughout life

Gene Wiki entry for CDKN1C (Cyclin-dependent_kinase_inhibitor_1C)

Genomic Location
for CDKN1C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CDKN1C gene  

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

CDKN1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002861:     (about GC identifiers)

Start:
 2,861,019 bp from pter
End:
 2,863,555 bp from pter
Size:
 2,537 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  

Proteins
for CDKN1C

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: CDN1C_HUMAN, P49918 (See protein sequence)
Recommended Name: Cyclin-dependent kinase inhibitor 1C  
Size: 316 amino acids; 32177 Da
Subcellular location: Nucleus (By similarity)
Alternative splicing: 2 isoforms:  P49918-1   P49918-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_000067.1  NP_001116102.1  NP_001116103.1  


    ENSEMBL proteins: 
    ENSP00000321019 ENSP00000370101 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (p57 Kip2)
    Human Recombinant Proteins from Abnova (CDKN1C)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA16943770 18029348
    About this table

    Antibodies for CDKN1C: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of CDKN1C
    Sigma-Aldrich Antibody Arrays and Antibodies for CDKN1C
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (p57 Kip2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CDKN1C)
    Novus Biologicals Antibody for CDKN1C

    Assays for CDKN1C: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for CDKN1C

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR003175 CDI


       GeneDecks  CDKN1C for the domains selected above  
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    Graphical View of Domain Structure for InterPro Entry P49918

    ProtoNet protein and cluster: P49918

    1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor

    UniProtKB/Swiss-Prot: CDN1C_HUMAN, P49918
    Similarity: Belongs to the CDI family

    Gene Function
    for CDKN1C

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CDKN1C)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CDKN1C)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000076

                  Applied Biosystems Silencer® siRNAs for CDKN1C

                  Sigma-Aldrich siRNA and siRNA Panels for CDKN1C  
                         Sigma-Aldrich shRNA Panels and shRNA for CDKN1C  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000076
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000076
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_000076 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000076

    UniProtKB/Swiss-Prot: CDN1C_HUMAN, P49918
    Function: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin
    D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative
    regulator of cell proliferation. May play a role in maintenance of the non-proliferative state
    throughout life

    Genatlas biochemistry entry for CDKN1C:
    cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p57 (KIP2),involved in the G1 phase
    arrest,regulator of cell cycle,critical terminal effector of signal transduction pathways that
    control cell differentiation,preferentially expressed from the maternal allele (paternally
    imprinted),mutated in familial Beckwith-Wiedemann syndrome or in patients with mosaic paternal
    isodisomies,controlling differentiation of skeletal muscle and alveoli in the lung in parallel
    with P21 and myogenin

    15/22 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cdkn1c) (see all 22 ):

    behavior/neurologicalcellularcraniofacialdigestive/alimentary
    embryogenesisendocrine/exocrine glandgrowth/sizehematopoietic systemhomeostasis/metabolism
    immune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tail

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860 protein kinase inhibitor activity IEA--
    GO:0004861 cyclin-dependent protein kinase inhibitor activity TAS7729684
    GO:0005515 protein binding IPI9106657
    GO:0045735 nutrient reservoir activity IEA--
    About this table

    Pathways & Interactions
    for CDKN1C

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for CDKN1C
     Transcription Role of VDR in regulation of genes involved in osteoporosis

       GeneDecks  CDKN1C for the pathways selected above  
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    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  CDKN1C  (Your Favorite Gene powered by Ingenuity) 
     Glucocorticoid Receptor Signaling

       GeneDecks  CDKN1C for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for CDKN1C):
     hsa04110 Cell cycle

       GeneDecks  CDKN1C for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CDKN1C 


    2 Interacting proteins for CDKN1C (P499181, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021EBI-519256, EBI-295644
    FBXL12Q9NXK82MINT-6804035 MINT-6804015 MINT-6803987 MINT-6804000 MINT-6803975 MINT-6804091
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079 regulation of cyclin-dependent protein kinase activity TAS7729684
    GO:0000080 G1 phase of mitotic cell cycle TAS7729684
    GO:0007050 cell cycle arrest TAS7729684
    GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP16943770
    GO:0045786 negative regulation of cell cycle IEA--
    About this table

    Drugs & Compounds
    for CDKN1C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for CDKN1C:
    Inhibitor

    Browse Tocris compounds for CDKN1C
    2 Novoseek chemical compound relationships for CDKN1C gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 4.18 1 14551533 (1)
    acth 0.00 1 9177379 (1)
    About this table


    Transcripts
    for CDKN1C

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CDKN1C)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CDKN1C)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000076

                  Sigma-Aldrich siRNA and siRNA Panels for CDKN1C  
                         Sigma-Aldrich shRNA Panels and shRNA for CDKN1C  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000076  NM_001122630  NM_001122631  

    REFSEQ mRNAs for CDKN1C gene (3 alternative transcripts): 

    NM_000076.2   NM_001122630.1   NM_001122631.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000076  NM_001122630  NM_001122631  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000076
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000076
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_000076 

    Additional cDNA sequence: 

    BC039188.1 BC067842.1 CR591638.1 CR605750.1 EU570054.1 U22398.1 

    7 DOTS entries:

    DT.451431  DT.91761320  DT.99974957  DT.95211419  DT.100781848  DT.100833529  DT.120680737 

    24/542 AceView cDNA sequences (see all 542 ):

    AI521194 AW024752 AI978714 CA776846 AW051576 AI033613 BF002322 AI089791 
    AI458925 R36168 BQ102202 BF196998 BM673714 CD676249 BE675663 T84306 
    AI149562 AI373334 BQ945970 CA942828 AI220670 W81170 BI439109 CD674854 

    highest scoring ESTs for CDKN1C:

    U22398 AI660190 BC067842 BE255483 BF726569 BI439016 BI439076 BI439085 BI918499 BM022003 

    Unigene Cluster for CDKN1C:

    Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
    Hs.106070  [show with all ESTs]
    Unigene Representative Sequence: NM_000076


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN1C

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -     -                     
    SP2:                          -     -                     
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      

    About this scheme

    ECgene alternative splicing isoforms for CDKN1C

    2 Ensembl transcripts including schematic representations:
    ENST00000313407  ENST00000380725  

    Expression
    for CDKN1C

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CDKN1C expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CDKN1C

    1 / 2 / 3

    11 probe-sets matching CDKN1C gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		39545_at2, 3 U95-A 1 1.00 1.00 0.97 1.35 U22398 1.00 1.00 1.00 1
    38673_s_at2, 3 U95-A 1 1.00 1.00 0.99 0.77 D64137 0.20 1.00 0.72 1
    1787_at2, 3 U95-A 2 1.00 0.97 0.99 0.90 U22398 1.00 1.00 1.00 1

    		213182_x_at2, 3 U133-A 1 1.00 1.00 -- -- R78668 0.40 1.00 0.76 1

    		213348_at2, 3 U133-A 1 1.00 1.00 -- -- N33167 0.40 1.00 0.76 1

    		216894_x_at2, 3 U133-A 1 1.00 1.00 -- -- D64137 0.20 1.00 0.72 1

    		219534_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000076 0.60 1.00 0.82 1

    		213182_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		213348_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		216894_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		219534_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  CDKN1C for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCCATCTAGC

    SOURCE GeneReport for Unigene cluster: Hs.106070

    Expression variation in blood from EXPOLDB for CDKN1C

    UniProtKB/Swiss-Prot: CDN1C_HUMAN, P49918
    Tissue specificity: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and
    testis. High levels are seen in the placenta while low levels are seen in the liver

    Orthologs
    for CDKN1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for CDKN1C gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    cow
    (Bos taurus)    		 CDKN1C1   -- cyclin-dependent kinase inhibitor 1C (p57, Kip2) 74.6(n)
    70.16(a)    		 510972  XM_001252310.1  XP_001252311.1 
    rat
    (Rattus norvegicus)    		 Cdkn1c1   -- cyclin-dependent kinase inhibitor 1C (P57) 72.83(n)
    61.39(a)    		 246060  NM_001033758.1  NP_001028930.1 
    mouse
    (Mus musculus)    		 Cdkn1c1, 5 7 (69.49 cM)5
    		 cyclin-dependent kinase inhibitor 1C (P57)1, 5 74.01(n)1
    64.69(a)1    		 125771  NM_009876.31  NP_034006.21 
     AF1601905  AI4283845  (see all 15)
    zebrafish
    (Danio rerio)    		 cdkn1c1   -- cyclin-dependent kinase inhibitor 1C (p57, Kip2) 50.26(n)
    40(a)    		 399483  NM_001002040.1  NP_001002040.1 
    rice
    (Oryza sativa)    		 Os.379272   -- Oryza sativa (japonica cultivar-group) cDNA cloneJ more 68.67(n)  AK100437.1 
    About this table        Species with no ortholog for CDKN1C

    ENSEMBL Gene Tree for CDKN1C

    Paralogs
    for CDKN1C

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CDKN1C gene
    CDKN1A2  CDKN1B2  

    SNPs/Variants
    for CDKN1C

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/42 NCBI SNPs in CDKN1C are shown (see all 42 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 58)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs4523381,2
    		C,F,H2864771(+) ATGAGG/TCAGGG 1 -- ng314Minor allele frequency- T:0.18EU EA WA 420
    --
    rs110244371,2
    		C,F,H2865232(+) TCTTAG/AGAAAA 1 -- ng3112Minor allele frequency- A:0.29EU EA WA 1256
    rs4505631,2
    		C,F,H2865541(+) CTGGAA/GGGAAG 1 -- ng315Minor allele frequency- G:0.29MN EU EA WA 596
    rs4312221,2
    		C,F2864975(+) CCCACC/TCCCAT 1 -- ng315Minor allele frequency- T:0.23MN CSAM EA 404
    rs4287301,2
    		C2865117(+) CCATTC/ATTGGC 1 -- ng315Minor allele frequency- A:0.00MN CSAM EA 404
    rs4209351,2
    		C2865124(+) TGGCTC/GTTGAT 1 -- ng315Minor allele frequency- G:0.00MN CSAM EA 404
    --
    rs4209031,2
    		C2865072(+) GTGAAC/GTGGAT 1 -- ng31 tfbs35Minor allele frequency- G:0.00MN CSAM EA 404
    --
    rs4209021,2
    		C2865070(+) GGGTGA/GASTGG 1 -- ng315Minor allele frequency- G:0.00MN CSAM EA 400
    --
    rs92826561,2
    		F2865233(-) GTTTTC/TYTAAG 1 -- ng315Minor allele frequency- T:0.17MN CSAM EA 368
    rs4287041,2
    		C2865079(+) GGATGG/AGACAG 1 -- ng31 tfbs35Minor allele frequency- A:0.00MN CSAM EA 404
    About this table

    HapMap Linkage Disequilibrium images for CDKN1C (up to first 250kb)

    Disorders & Mutations
    for CDKN1C

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 600856   disorders: 130650  

    UniProtKB/Swiss-Prot: CDN1C_HUMAN, P49918

  • Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a
    genetically heterogeneous disorder characterized by anterior abdominal wall defects including
    exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less
    frequent complications include specific developmental defects and a predisposition to embryonal
    tumors
  • Defects in CDKN1C are involved in tumor formation

    • 10/56 Novoseek disease relationships for CDKN1C gene (see all 56 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 94.10 48 8841187 (3), 10862080 (2), 15888726 (2), 16061564 (2) (see all 36)
    hydatidiform mole 73.33 10 15279631 (3), 12823708 (2), 15533819 (1), 17904617 (1) (see all 6)
    embryonal tumor 69.26 1 17638616 (1)
    macroglossia 62.56 1 17638616 (1)
    wilms tumor 61.81 10 8889507 (4), 9461119 (2), 8640801 (2), 8640800 (1)
    carcinoma adrenocortical 52.63 3 9177379 (2)
    umbilical hernia 51.71 3 10424811 (1), 11106355 (1), 15999116 (1)
    glomerulosclerosis, focal segmental 51.54 2 12631353 (1), 10916090 (1)
    omphalocele 50.29 5 17638616 (2), 18395877 (1)
    trophoblastic disease 49.13 2 9520940 (1), 15270611 (1)
    About this table

    GeneTests: CDKN1C
    Beckwith-Wiedemann Syndrome

    Human Gene Mutation Database: CDKN1C
    Genetic Association Database: CDKN1C
    Human Genome Epidemiology Navigator: CDKN1C (6 documents)

    Medical News
    for CDKN1C

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for CDKN1C

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/273 PubMed articles for CDKN1C gene (see all 273 ):

    Search for CDKN1C

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDKN1C

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 1028 HGNC: 1786 AceView: CDKN1C Ensembl:ENSG00000129757 euGenes: HUgn1028
    ECgene: CDKN1C H-InvDB: CDKN1C

    Other Databases showing CDKN1C

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing CDKN1C

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CDKN1C Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=CDKN1C

    Licensable Technologies
    for CDKN1C

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for CDKN1C

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CDKN1C:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CDKN1C-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for CDKN1C Antibodies for CDKN1C
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CDKN1C Small molecules for CDKN1C
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (CDKN1C)
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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (p57 Kip2)
     Antibodies (p57 Kip2)
     Search OriGene for CDKN1C
     Search Tocris compounds for CDKN1C




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for CDKN1C

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