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CDKN1B Gene

protein-coding   GIFtS: 72
GCID: GC12P012867

Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1)

  See CDKN1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1)1 2     P27KIP12
KIP12 3 5     Cyclin-Dependent Kinase Inhibitor 1B2
CDKN42 5     Cyclin-Dependent Kinase Inhibitor P273
MEN42 5     p27Kip13
MEN1B2     

External Ids:    HGNC: 17851   Entrez Gene: 10272   Ensembl: ENSG000001112767   OMIM: 6007785   UniProtKB: P465273   
ORGUL members:         

Export aliases for CDKN1B gene to outside databases

Previous GC identifers: GC12P012597 GC12P013015 GC12P012768 GC12P012761 GC12P012639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKN1B Gene:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor
CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes,
and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its
CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular
transition from quiescence to the proliferative state. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDKN1B Gene:
CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)) is a protein-coding gene. Diseases associated with CDKN1B include mature t-cell and nk-cell neoplasm, and periampullary adenocarcinoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein phosphatase binding. An important paralog of this gene is CDKN1C.

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and
cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly,
stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin
type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry

Gene Wiki entry for CDKN1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN1B gene promoter:
         AP-1   ATF-2   MyoD   GATA-1   FOXO4   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN1B promoter sequence
   Search Chromatin IP Primers for CDKN1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1-p12   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.1-p12

CDKN1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P012867:  view genomic region     (about GC identifiers)

Start:
12,867,992 bp from pter      End:
12,875,305 bp from pter
Size:
7,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527 (See protein sequence)
Recommended Name: Cyclin-dependent kinase inhibitor 1B  
Size: 198 amino acids; 22073 Da
Subunit: Forms a ternary complex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is
inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome
complex; the interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear
import and degradation of phosphorylated CDKN1B. Interacts with CCND1 and SNX6 (By similarity). Interacts
(Thr-198-phosphorylated form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB
nor YWHAZ; the interaction with YWHAQ results in translocation to the cytoplasm. Interacts with AKT1 and LYN; the
interactions lead to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest.
Interacts (unphosphorylated form) with CDK2. Forms a ternary complex, cyclin D/CDK4/CDKN1B. Interacts
(phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction is required for cyclin D/CDK4 complex assembly,
induces nuclear translocation and activates the CDK4 kinase activity. Interacts with GRB2. Interacts with PIM1.
Identified in a complex with SKP1, SKP2 and CKS1B. Interacts with UHMK1; the interaction leads to cytoplasmic
mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts also with CDK1
Miscellaneous: Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial
tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate
3 PDB 3D structures from and Proteopedia for CDKN1B:
1H27 (3D)        1JSU (3D)        2AST (3D)    
Secondary accessions: Q16307 Q5U0H2 Q9BUS6

Explore the universe of human proteins at neXtProt for CDKN1B: NX_P46527

Explore proteomics data for CDKN1B at MOPED

Post-translational modifications: 

  • Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is
    the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein
    stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain
    cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is
    required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK1 and CDK2 leads to protein
    ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by
    PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88
    and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues
    by G-CSF1
  • Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus,
    by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing
    SCF(SKP2)-like complex; leads to its degradation1
  • Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDKN1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004055.1  
    ENSEMBL proteins: 
     ENSP00000228872   ENSP00000379629   ENSP00000407597  
    Reactome Protein details: P46527

    CDKN1B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDKN1B
    Cloud-Clone Corp. Proteins for CDKN1B

     
    Search eBioscience for Proteins for CDKN1B 

    CDKN1B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN1B
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    Enzo Life Sciences assays for CDKN1B
    Cloud-Clone Corp. ELISAs for CDKN1B
    Cloud-Clone Corp. CLIAs for CDKN1B
    Search eBioscience for ELISAs for CDKN1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003175 CDI

    Graphical View of Domain Structure for InterPro Entry P46527

    ProtoNet protein and cluster: P46527

    1 Blocks protein domain: IPB003175 Cyclin-dependent kinase inhibitor

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Domain: A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity
    Similarity: Belongs to the CDI family


    Find genes that share domains with CDKN1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN1B_HUMAN, P46527
    Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and
    cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly,
    stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin
    type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry
    Induction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cells
    progress toward S-phase

         Genatlas biochemistry entry for CDKN1B:
    cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and in the cellular
    response after DNA damage in cell cycle exit in megacaryocyte,regulator of cell cycle,critical terminal effector
    of signal transduction pathways that control cell differentiation,overexpressed with CCND3 in agressive B cell
    lymphomas,underexpressed in the development and progression of oral squamous cell carcinoma and in
    thyroid,colon,breast,prostate and superficial bladder carcinomas,deleted in leukemias and other cancers with poor
    prognosis (pancreatic adenocarcinomas)degraded by proteasomes in gliomas

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IEA--
    GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activity TAS8033212
    GO:0005515protein binding IPI12082530
    GO:0008656contributes to cysteine-type endopeptidase activator activity involved in apoptotic process IDA19266349
    GO:0019903protein phosphatase binding IPI19838216
         
    Find genes that share ontologies with CDKN1B           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDKN1B:
     Cell division defect  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Increased cell number in G2M,  

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Cdkn1b) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with CDKN1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDKN1B: Cdkn1btm1Kin Cdkn1btm1Ako Cdkn1btm2.1Mlf Cdkn1btm3Mlf Cdkn1btm1Mlf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKN1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDKN1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN1B

    miRNA
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    miRTarBase miRNAs that target CDKN1B:
    hsa-mir-192-5p (MIRT005064), hsa-mir-181a-5p (MIRT004554), hsa-mir-222-3p (MIRT000131), hsa-mir-221-3p (MIRT000137), hsa-mir-1260b (MIRT052676), hsa-mir-98-5p (MIRT027709), hsa-mir-190a-5p (MIRT005066), hsa-mir-24-3p (MIRT005063), hsa-mir-128b (MIRT006589), hsa-mir-218-5p (MIRT005067), hsa-mir-196a-5p (MIRT005065)

    Block miRNA regulation of human, mouse, rat CDKN1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKN1B (see all 60):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-429 hsa-miR-488 hsa-miR-105 hsa-miR-3171 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidCDKN1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDKN1B

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    Clone
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    Addgene plasmids for CDKN1B 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDN1B_HUMAN, P46527: Nucleus. Cytoplasm. Endosome (By similarity). Note=Nuclear and cytoplasmic in quiescent
    cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes
    cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the
    cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the
    nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal
    degradation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    endosome2
    extracellular2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11800646
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA12093740
    GO:0005768endosome IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDKN1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKN1B About   (see all 70)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    5Glioma
    Prostate cancer0.39
    Signaling Pathways in Glioblastoma0.36


    Find genes that share SuperPaths with CDKN1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CDKN1B
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDKN1B (see all 13)
        ErbB2-ErbB3 Heterodimers
    HGF Pathway
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling

    1 Cell Signaling Technology (CST) Pathway for CDKN1B
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CDKN1B (see all 8)
        Signal transduction AKT signaling
    Development Thrombopoietin-regulated cell processes
    Development Role of Activin A in cell differentiation and proliferation
    Cell cycle Role of SCF complex in cell cycle regulation
    Development Thrombopoetin signaling via JAK-STAT pathway

    Selected BioSystems Pathways for CDKN1B (see all 28)
        Cell cycle
    DNA damage response
    Senescence and Autophagy
    G1 to S cell cycle control
    DNA damage response (only ATM dependent)


    Selected Reactome Pathways for CDKN1B (see all 10)
        AKT phosphorylates targets in the cytosol
    SCF(Skp2)-mediated degradation of p27/p21
    Orc1 removal from chromatin
    Cyclin E associated events during G1/S transition
    p53-Dependent G1 DNA Damage Response

    1 PharmGKB Pathway for CDKN1B
        Celecoxib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CDKN1B) (see all 15):
        ErbB signaling pathway
    HIF-1 signaling pathway
    FoxO signaling pathway
    Cell cycle
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN1B (see all 15): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDKN1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDKN1B (P465271, 2, 3 ENSP000002288724) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273481, 2, 3, ENSP000002380814EBI-519280,EBI-359854 MINT-8006094 MINT-17888 MINT-8008250 MINT-8008504 MINT-17889 MINT-8007803 MINT-8008511 I2D: score=5 STRING: ENSP00000238081
    CCND2P302792, 3, ENSP000002612544MINT-67874 I2D: score=6 STRING: ENSP00000261254
    ARHGDIAP525652, 3, ENSP000002693214MINT-63858 I2D: score=5 STRING: ENSP00000269321
    CCNA2P202481, 3, ENSP000002740264EBI-519280,EBI-457097 I2D: score=5 STRING: ENSP00000274026
    COPS5Q929051, 3, ENSP000003505124EBI-519280,EBI-594661 I2D: score=5 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS8033212
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001666response to hypoxia IEA--
    GO:0006813potassium ion transport IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKN1B (CDN1B)

    Selected Novoseek inferred chemical compound relationships for CDKN1B gene (see all 102)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 55.1 8 15588951 (2), 12242656 (1), 19443725 (1), 11709727 (1) (see all 7)
    leptomycin b 50.2 9 15735731 (3), 16842750 (1), 11889117 (1)
    eb 1089 49.4 6 12586749 (3), 16340750 (2), 10640426 (1)
    1,25 dihydroxy vitamin d3 44.6 17 9697881 (5), 9652739 (2), 16883603 (1), 16322758 (1) (see all 8)
    mg 132 43.8 2 15173011 (1), 12646415 (1)
    ciglitazone 43.5 9 15763423 (6), 15951157 (1)
    trastuzumab 43.1 20 15611642 (6), 14648698 (3), 15173011 (2), 15642702 (1) (see all 7)
    bromodeoxyuridine 43 2 11738067 (1)
    mimosine 42.6 8 10623466 (4), 10530763 (1), 15855174 (1), 15923641 (1)
    rapamycin 41.5 14 20097763 (3), 8895523 (2), 12393532 (1), 16862180 (1) (see all 9)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDKN1B gene: 
    NM_004064.4  

    Unigene Cluster for CDKN1B:

    Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
    Hs.238990  [show with all ESTs]
    Unigene Representative Sequence: NM_004064
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477087 ENST00000228872(uc001rat.2) ENST00000396340 ENST00000442489

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    hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-429 hsa-miR-488 hsa-miR-105 hsa-miR-3171 hsa-miR-890
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    Flow Cytometry
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    Additional mRNA sequence: 

    AB451291.1 AB451423.1 AF247551.1 AJ616234.1 AK298335.1 AK312461.1 AY004255.1 BC001971.1 
    BT019553.1 BT019554.1 CR457399.1 U10906.1 

    13 DOTS entries:

    DT.417848  DT.100820961  DT.95238381  DT.95374074  DT.100820955  DT.100820956  DT.101970489  DT.121171409 
    DT.121171413  DT.91687599  DT.95374072  DT.95374076  DT.92038526 

    Selected AceView cDNA sequences (see all 236):

    U10906 AA988214 BF221469 BG928753 CA450020 AW022687 H13167 AI419631 
    AA897321 CB216548 AA749161 AA737055 R81658 CR592928 CA337570 AA429206 
    AA563693 BM055406 AI201163 AI671934 NM_004064 AW023852 AI339337 BF061836 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKN1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTGCAT
    CDKN1B Expression
    About this image


    CDKN1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Muller Glia Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
    CDKN1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKN1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.238990

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN1B (see all 15): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
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              Leukemia in human mouse rat
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN1B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn1b1 , 5 cyclin-dependent kinase inhibitor 1B1, 5 87.24(n)1
    87.76(a)1
      6 (65.77 cM)5
    125761  NM_009875.41  NP_034005.21 
     1349204015 
    chicken
    (Gallus gallus)
    Aves CDKN1B1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) 76.6(n)
    68.69(a)
      374106  NM_204256.2  NP_989587.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDKN1B6
    cyclin-dependent kinase inhibitor 1B (p27, Kip1)
    41(a)
    1 ↔ 1
    GL343579.1(387419-392046)
    zebrafish
    (Danio rerio)
    Actinopterygii BC056746.12   -- 76.24(n)    BC056746.1 


    ENSEMBL Gene Tree for CDKN1B (if available)
    TreeFam Gene Tree for CDKN1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKN1B gene
    CDKN1C2  CDKN1A2  
    3 SIMAP similar genes for CDKN1B using alignment to 6 protein entries:     CDN1B_HUMAN (see all proteins):
    p27 kip1    CDKN1C    CDKN1A

    Find genes that share paralogs with CDKN1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKN1B (see all 194)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178321,2
    Cpathogenic112740089(+) CGAGTA/GGCAAG 2 * W stg10--------
    rs362282031,2
    C--12737489(+) ACCCC-/TGTCCT 1 -- us2k10--------
    rs37592171,2
    C,F,H--12737540(+) CAAGAC/TAGCTG 1 -- us2k127Minor allele frequency- T:0.07EA NA NS CSA WA 4394
    rs1413280631,2
    --12737601(+) ACCCAC/GGGCCT 1 -- us2k10--------
    rs1149625571,2
    F--12737760(+) CTAGTC/TCTGAC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs357567411,2
    C,F--12737789(-) CCAGGG/AACATG 1 -- us2k15Minor allele frequency- A:0.08NA CSA WA 244
    rs1470197341,2
    --12737831(+) CGTGGC/TAAAAA 1 -- us2k10--------
    rs1381869511,2
    --12738131(+) CCCTGC/TTCATC 1 -- us2k10--------
    rs773882281,2
    C--12738247(+) GACATC/GGTTGT 1 -- us2k10--------
    rs1821637241,2
    --12738354(+) TGTTCG/TGAGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDKN1B (12867992 - 12875305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDKN1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745567CNV Deletion23290073
    nsv898812CNV Loss21882294
    nsv898813CNV Loss21882294
    nsv898811CNV Gain21882294

    Human Gene Mutation Database (HGMD): CDKN1B
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CDKN1B:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing CDKN1B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600778   
    OMIM disorders: 610755  
    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
  • Multiple endocrine neoplasia 4 (MEN4) [MIM:610755]: Multiple endocrine neoplasia (MEN) syndromes are
    inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and
    MEN2. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for CDKN1B (see all 22):    
    About MalaCards
    mature t-cell and nk-cell neoplasm    periampullary adenocarcinoma    multiple endocrine neoplasia type 4    wermer syndrome
    familial isolated pituitary adenoma    blastic plasmacytoid dendritic cell    multiple endocrine neoplasia    hypervitaminosis a
    small cell neuroendocrine carcinoma    t-cell prolymphocytic leukemia    follicular adenoma    papilloma
    renal fibrosis    cervical adenocarcinoma    tuberous sclerosis    cholangiocarcinoma
    adenocarcinoma    colorectal cancer    hepatocellular carcinoma    pancreatic cancer

    8 diseases from the University of Copenhagen DISEASES database for CDKN1B:
    Retinoblastoma     Carcinoma     Wermer syndrome     Carney complex
    Leukemia     Breast cancer     Prostate cancer     Adenoma

    Find genes that share disorders with CDKN1B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDKN1B gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 80.4 45 12783864 (2), 9083081 (2), 16740772 (2), 8916935 (1) (see all 40)
    tumors 68.8 455 12605366 (8), 10329035 (6), 19293259 (5), 10559792 (5) (see all 99)
    cancer 61 123 9683802 (3), 11266285 (2), 19082479 (2), 10404130 (2) (see all 82)
    aggressiveness 56.8 15 19866239 (2), 10223564 (2), 9864434 (1), 10514396 (1) (see all 13)
    multiple endocrine neoplasia type 1 56 5 17613552 (1), 18673462 (1), 17299066 (1), 17803708 (1)
    prostate cancer 52.5 71 15265403 (4), 14960249 (3), 17070313 (3), 9458103 (3) (see all 37)
    multiple endocrine neoplasia 51.8 8 17961654 (1), 18710468 (1), 17097557 (1), 17613552 (1) (see all 5)
    carcinoma 51.7 63 18036045 (5), 9426067 (5), 12150617 (3), 9466585 (3) (see all 33)
    carcinoma squamous cell 51.2 35 11854065 (2), 15645120 (2), 9683778 (2), 12530030 (2) (see all 28)
    lip squamous cell carcinoma 50.6 3 14662421 (2), 15743689 (1)

    Genetic Association Database (GAD): CDKN1B
    Human Genome Epidemiology (HuGE) Navigator: CDKN1B (63 documents)
    Tumor Gene Database (TGDB): CDKN1B

    Export disorders for CDKN1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKN1B gene, integrated from 10 sources (see all 1612):
    (articles sorted by number of sources associating them with CDKN1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. (PubMed id 8033212)1, 2, 3, 9 Polyak K.... Massague J. (Cell 1994)
    2. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2, 9 Fujita N.... Tsuruo T. (J. Biol. Chem. 2002)
    3. [Association of polymorphisms of p21cip1 and p27kip1 genes with susceptibilities of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (PubMed id 16480585)1, 4, 9 Guo W....Zhang J.H. (Ai Zheng 2006)
    4. Allelic variant at -79 (C&gt;T) in CDKN1B (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels. (PubMed id 20075119)1, 4, 9 Landa I....Robledo M. (Endocr. Relat. Cancer 2010)
    5. Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4, 9 Jardin F....Tilly H. (Br. J. Haematol. 2009)
    6. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. (PubMed id 17008550)1, 4, 9 Healy J....Sinnett D. (Blood 2007)
    7. Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women. (PubMed id 16804901)1, 4, 9 Ma H....Shen H. (Int. J. Cancer 2006)
    8. The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PubMed id 15627896)1, 4, 9 SchAPndorf T....Hoopmann M. (Tumour Biol. 2004)
    9. Germline mutations in the CDKN1B gene encoding p27 Kip1 are a rare cause of multiple endocrine neoplasia type 1. (PubMed id 18673462)1, 4, 9 Owens M....Vaidya B. (Clin. Endocrinol. (Oxf) 2009)
    10. No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 18543099)1, 4, 9 Spurdle A.B....Chenevix-Trench G. (Breast Cancer Res. Treat. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1027 HGNC: 1785 AceView: CDKN1B Ensembl:ENSG00000111276 euGenes: HUgn1027
    ECgene: CDKN1B Kegg: 1027 H-InvDB: CDKN1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDKN1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDKN1B gene:
    Search GeneIP for patents involving CDKN1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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