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Aliases for CDKN1B Gene

Aliases for CDKN1B Gene

  • Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1) 2 3
  • KIP1 3 4 6
  • P27KIP1 3 4
  • CDKN4 3 6
  • MEN4 3 6
  • Cyclin-Dependent Kinase Inhibitor P27 4
  • Cyclin-Dependent Kinase Inhibitor 1B 3
  • MEN1B 3

External Ids for CDKN1B Gene

Summaries for CDKN1B Gene

Entrez Gene Summary for CDKN1B Gene

  • This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

GeneCards Summary for CDKN1B Gene

CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1)) is a Protein Coding gene. Diseases associated with CDKN1B include periampullary adenocarcinoma and multiple endocrine neoplasia, type iv. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein phosphatase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN1A.

UniProtKB/Swiss-Prot for CDKN1B Gene

  • Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Wiki entry for CDKN1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN1B Gene

Genomics for CDKN1B Gene

Genomic Location for CDKN1B Gene

Start:
12,715,058 bp from pter
End:
12,722,371 bp from pter
Size:
7,314 bases
Orientation:
Plus strand

Genomic View for CDKN1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKN1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN1B Gene

Regulatory Elements for CDKN1B Gene

Proteins for CDKN1B Gene

  • Protein details for CDKN1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46527-CDN1B_HUMAN
    Recommended name:
    Cyclin-dependent kinase inhibitor 1B
    Protein Accession:
    P46527
    Secondary Accessions:
    • Q16307
    • Q5U0H2
    • Q9BUS6

    Protein attributes for CDKN1B Gene

    Size:
    198 amino acids
    Molecular mass:
    22073 Da
    Quaternary structure:
    • Forms a ternary complex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated CDKN1B. Interacts with CCND1 and SNX6 (By similarity). Interacts (Thr-198-phosphorylated form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocation to the cytoplasm. Interacts with AKT1 and LYN; the interactions lead to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts (unphosphorylated form) with CDK2. Forms a ternary complex, cyclin D/CDK4/CDKN1B. Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction is required for cyclin D/CDK4 complex assembly, induces nuclear translocation and activates the CDK4 kinase activity. Interacts with GRB2. Interacts with PIM1. Identified in a complex with SKP1, SKP2 and CKS1B. Interacts with UHMK1; the interaction leads to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts also with CDK1. Dephosphorylated on Thr-187 by PPM1H, leading to CDKN1B stability (PubMed:22586611).
    Miscellaneous:
    • Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate

    Three dimensional structures from OCA and Proteopedia for CDKN1B Gene

neXtProt entry for CDKN1B Gene

Proteomics data for CDKN1B Gene at MOPED

Post-translational modifications for CDKN1B Gene

  • Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK1 and CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.
  • Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity).
  • Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDKN1B Gene

Domains for CDKN1B Gene

Protein Domains for CDKN1B Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CDN1B_HUMAN
Domain:
  • A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity:
    • P46527
Family:
  • Belongs to the CDI family.:
    • P46527
genes like me logo Genes that share domains with CDKN1B: view

No data available for Gene Families for CDKN1B Gene

Function for CDKN1B Gene

Molecular function for CDKN1B Gene

GENATLAS Biochemistry: cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and in the cellular response after DNA damage in cell cycle exit in megacaryocyte,regulator of cell cycle,critical terminal effector of signal transduction pathways that control cell differentiation,overexpressed with CCND3 in agressive B cell lymphomas,underexpressed in the development and progression of oral squamous cell carcinoma and in thyroid,colon,breast,prostate and superficial bladder carcinomas,deleted in leukemias and other cancers with poor prognosis (pancreatic adenocarcinomas)degraded by proteasomes in gliomas
UniProtKB/Swiss-Prot Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
UniProtKB/Swiss-Prot Induction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cells progress toward S-phase.

Gene Ontology (GO) - Molecular Function for CDKN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA --
GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity TAS 8033212
GO:0005515 protein binding IPI 12082530
GO:0008656 contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process IDA 19266349
GO:0019903 protein phosphatase binding IPI 19838216
genes like me logo Genes that share ontologies with CDKN1B: view
genes like me logo Genes that share phenotypes with CDKN1B: view

Animal Models for CDKN1B Gene

MGI Knock Outs for CDKN1B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDKN1B Gene

Localization for CDKN1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKN1B Gene

Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKN1B Gene COMPARTMENTS Subcellular localization image for CDKN1B gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
endosome 2
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDKN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11800646
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 12093740
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDKN1B: view

Pathways for CDKN1B Gene

SuperPathways for CDKN1B Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 PI-3K cascade
3 Signaling by FGFR
4 Cyclins and Cell Cycle Regulation
.31
5 Cell cycle Role of SCF complex in cell cycle regulation
genes like me logo Genes that share pathways with CDKN1B: view

Gene Ontology (GO) - Biological Process for CDKN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8033212
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001666 response to hypoxia IEA --
GO:0006813 potassium ion transport IEA --
genes like me logo Genes that share ontologies with CDKN1B: view

Compounds for CDKN1B Gene

(102) Novoseek inferred chemical compound relationships for CDKN1B Gene

Compound -log(P) Hits PubMed IDs
ly294002 55.1 8
leptomycin b 50.2 5
eb 1089 49.4 6
1,25 dihydroxy vitamin d3 44.6 13
mg 132 43.8 2
genes like me logo Genes that share compounds with CDKN1B: view

Transcripts for CDKN1B Gene

mRNA/cDNA for CDKN1B Gene

Unigene Clusters for CDKN1B Gene

Cyclin-dependent kinase inhibitor 1B (p27, Kip1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN1B Gene

No ASD Table

Relevant External Links for CDKN1B Gene

GeneLoc Exon Structure for
CDKN1B
ECgene alternative splicing isoforms for
CDKN1B

Expression for CDKN1B Gene

mRNA expression in normal human tissues for CDKN1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKN1B Gene

SOURCE GeneReport for Unigene cluster for CDKN1B Gene Hs.238990

mRNA Expression by UniProt/SwissProt for CDKN1B Gene

P46527-CDN1B_HUMAN
Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney
genes like me logo Genes that share expressions with CDKN1B: view

Orthologs for CDKN1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDKN1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN1B 36
  • 100 (n)
  • 100 (a)
CDKN1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN1B 36
  • 90.24 (n)
  • 90.91 (a)
CDKN1B 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN1B 36
  • 89.56 (n)
  • 90.4 (a)
CDKN1B 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkn1b 36
  • 87.24 (n)
  • 87.76 (a)
Cdkn1b 16
Cdkn1b 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDKN1B 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDKN1B 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkn1b 36
  • 87.59 (n)
  • 87.24 (a)
chicken
(Gallus gallus)
Aves CDKN1B 36
  • 76.6 (n)
  • 68.69 (a)
CDKN1B 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKN1B 37
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdkn1ba 37
  • 39 (a)
OneToMany
cdkn1bb 37
  • 42 (a)
OneToMany
cdkn1bb 37
  • 42 (a)
OneToMany
LOC100534692 36
  • 64.16 (n)
  • 60.22 (a)
Species with no ortholog for CDKN1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN1B Gene

ENSEMBL:
Gene Tree for CDKN1B (if available)
TreeFam:
Gene Tree for CDKN1B (if available)

Paralogs for CDKN1B Gene

Paralogs for CDKN1B Gene

Selected SIMAP similar genes for CDKN1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CDKN1B: view

Variants for CDKN1B Gene

Sequence variations from dbSNP and Humsavar for CDKN1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7330 -- 12,721,983(+) TTTTT(A/C)AAGGA utr-variant-3-prime
rs10237 -- 12,722,071(-) TTTTC(A/C)ATACA utr-variant-3-prime
rs34326 -- 12,722,532(-) GAAAA(C/T)AGTAA downstream-variant-500B
rs34327 -- 12,720,814(+) TTGCC(C/T)ACTGT intron-variant
rs34328 -- 12,720,719(+) TCACA(C/T)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN1B Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv898811 CNV Gain 21882294
nsv898812 CNV Loss 21882294
nsv898813 CNV Loss 21882294

Relevant External Links for CDKN1B Gene

HapMap Linkage Disequilibrium report
CDKN1B
Human Gene Mutation Database (HGMD)
CDKN1B

Disorders for CDKN1B Gene

(1) OMIM Diseases for CDKN1B Gene (600778)

UniProtKB/Swiss-Prot

CDN1B_HUMAN
  • Multiple endocrine neoplasia 4 (MEN4) [MIM:610755]: Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2. Note=The disease is caused by mutations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for CDKN1B Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 80.4 43
tumors 68.8 233
cancer 61 100
aggressiveness 56.8 15
multiple endocrine neoplasia type 1 56 4

Relevant External Links for CDKN1B

Genetic Association Database (GAD)
CDKN1B
Human Genome Epidemiology (HuGE) Navigator
CDKN1B
Tumor Gene Database (TGDB):
CDKN1B
genes like me logo Genes that share disorders with CDKN1B: view

Publications for CDKN1B Gene

  1. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PMID: 12042314) Fujita N. … Tsuruo T. (J. Biol. Chem. 2002) 3 4 23
  2. A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction. (PMID: 15061869) GonzA!lez P. … AndrAcs V. (BMC Biol. 2004) 3 23 49
  3. The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PMID: 15627896) SchAPndorf T. … Hoopmann M. (Tumour Biol. 2004) 3 23 49
  4. [Association of polymorphisms of p21cip1 and p27kip1 genes with susceptibilities of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (PMID: 16480585) Guo W. … Zhang J.H. (Ai Zheng 2006) 3 23 49
  5. Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women. (PMID: 16804901) Ma H. … Shen H. (Int. J. Cancer 2006) 3 23 49

Products for CDKN1B Gene

Sources for CDKN1B Gene

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