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CDKN1B Gene

protein-coding GIFtS: 71

GC12P012761

cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDKN4 ^², ⁵
KIP1 ^¹, ², ³, ⁵
MEN1B ^²
MEN4 ^², ⁵
P27KIP1 ^¹, ²
p27Kip1 ^³

Descriptions
Cyclin-dependent kinase inhibitor p27 ^³
cyclin-dependent kinase inhibitor 1B ^²
cyclin-dependent kinase inhibitor 1B (p27, Kip1) ^²

External Ids
HGNC: 1785¹
Entrez Gene: 1027²
UniProtKB: P46527³
Ensembl: ENSG00000111276⁷

Search outside databases for aliases for CDKN1B gene

Previous GC identifers: GC12P012597 GC12P013015 GC12P012768

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDKN1B:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK

inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or

cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of

this protein, which is triggered by its CDK dependent phosphorylation and subsequent

ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the

proliferative state. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Function: Important regulator of cell cycle progrssion. Involved in G1 arrest. Potent inhibitor of

cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as

CDK4. Regulated by phosphorylation and degradation events

Gene Wiki entry for CDKN1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDKN1B gene

Entrez Gene cytogenetic band: 12p13.1-p12 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p13.1-p12

CDKN1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P012761: (about GC identifiers)

Start:	12,761,576 bp from pter
End:	12,766,570 bp from pter
Size:	4,995 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527 (See protein sequence)

Recommended Name: Cyclin-dependent kinase inhibitor 1B

Size: 198 amino acids; 22073 Da

Subunit: Interacts with NUP50; the interaction leads to nuclear import and degradation of

phosphorylated p27kip1. Interacts with COPS5, subunit of the COP9 signalosome complex; the

interaction leads to p27KIP degradation. Interacts with SPDYA in the SPDYA/CDK2/p27kip1 complex.

Interacts (Thr-198 phosphorylated-form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE

and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocation to the

cytoplasm. Interacts with AKT1, LYN and UHMK1; the interactions lead to cytoplasmic mislocation,

phosphorylation of p27kip1 and inhibition of cell cycle arrest. Interacts (unphosphorylated form)

with CDK2. Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction induces

nuclear translocation. Interacts with GRB2

Subcellular location: Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or

RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes

cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in

translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates

nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89

Miscellaneous: Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in

various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and

prostate

PDB structures from and Proteopedia :

1H27 (3D)

1JSU (3D)

2AST (3D)

Secondary accessions: Q16307 Q5U0H2 Q9BUS6

Post-translational modifications:

Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation

on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1)

phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by

mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in

the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3

proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal

degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be

suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88

and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on

tyrosine residues by G-CSF¹

Ubiquitinated; in the cytoplasm by the KPC1/KPC2 complex and, in the nucleus, by SCF/SKP2. The

latter requires prior phosphorylation on Thr-187¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004055.1

ENSEMBL proteins:

ENSP00000228872 ENSP00000379629

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for CDKN1B
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tumour suppressors, p27 KIP 1)
	Human Recombinant Proteins from Abnova (CDKN1B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12093740
GO:0005737	cytoplasm	IDA	12093740
GO:0005829	cytosol	EXP	12244303

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Antibodies for CDKN1B:

	Invitrogen Antibodies for CDKN1B
	Millipore Mono- and Polyclonal Antibodies for the study of CDKN1B
	Sigma-Aldrich Antibodies for CDKN1B
	R&D Systems Antibodies for CDKN1B (p27/Kip1)
	Cell Signaling Technology (CST) Antibodies for CDKN1B (p27Kip1)
	Antibodies from Abcam (Tumour suppressors, p27 KIP 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDKN1B)
	Novus Biologicals Antibodies for CDKN1B

Assays for CDKN1B:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CDKN1B
	R&D Systems ELISAs for CDKN1B (p27/Kip1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P46527

ProtoNet protein and cluster: P46527

1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Domain: A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2

inhibitory activity

Similarity: Belongs to the CDI family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN1B)
		Millipore RNAi Products for the Analysis of CDKN1B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDKN1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004064

Applied Biosystems Silencer® siRNAs for CDKN1B

Sigma-Aldrich siRNA and siRNA Panels for CDKN1B

Sigma-Aldrich shRNA Panels and shRNA for CDKN1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDKN1B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004064
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004064
untagged cDNA clone in CMV expression vector: NM_004064

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004064

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Function: Important regulator of cell cycle progrssion. Involved in G1 arrest. Potent inhibitor of

cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as

CDK4. Regulated by phosphorylation and degradation events

Induction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen

stimulation as cells progress toward S-phase

Genatlas biochemistry entry for CDKN1B:

cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and

in the cellular response after DNA damage in cell cycle exit in megacaryocyte,regulator of cell

cycle,critical terminal effector of signal transduction pathways that control cell

differentiation,overexpressed with CCND3 in agressive B cell lymphomas,underexpressed in the

development and progression of oral squamous cell carcinoma and in thyroid,colon,breast,prostate

and superficial bladder carcinomas,deleted in leukemias and other cancers with poor prognosis

(pancreatic adenocarcinomas)degraded by proteasomes in gliomas

15/24 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Cdkn1b) (see all 24 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004860	protein kinase inhibitor activity	IEA	--
GO:0004861	cyclin-dependent protein kinase inhibitor activity	TAS	10918569
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	TAS	8033212
GO:0005515	protein binding	IPI	8756624 9840943 12082530 15057270 15652749 15890360 16326706 17254966 17254967

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for CDKN1B (Your Favorite Gene powered by Ingenuity) (see all 12 )

Molecular Mechanisms of Cancer
VDR/RXR Activation
Prostate Cancer Signaling
Antiproliferative Role of Somatostatin Receptor 2
Aryl Hydrocarbon Receptor Signaling

GeneDecks CDKN1B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDKN1B

5/196 Interacting proteins for CDKN1B (ENSP00000228872³ P46527^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 196 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCNA2	P20248¹	STRING (score=.999) EBI-519280, EBI-457097
CCND1	P24385¹	STRING (score=.999) EBI-519280, EBI-375001
CCNE1	P24864¹	STRING (score=.999) EBI-519280, EBI-519526
CCNE2	O96020¹	STRING (score=.995) EBI-519280, EBI-375033
CDK5	Q00535¹	STRING (score=.974) EBI-519280, EBI-1041567

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	8033212
GO:0000082	G1/S transition of mitotic cell cycle	IDA	10208428
GO:0006917	induction of apoptosis	IDA	10208428
GO:0007049	cell cycle	IEA	--
GO:0007050	cell cycle arrest	IMP	12093740

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CDKN1B:

Inhibitor

Browse Tocris compounds for CDKN1B
10/39 Novoseek chemical compound relationships for CDKN1B gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1,25 dihydroxy vitamin d3	43.95	17	9697881 (5), 9652739 (2), 16883603 (1), 16322758 (1) (see all 8)
mimosine	43.86	8	10623466 (4), 10530763 (1), 15855174 (1), 15923641 (1)
bromodeoxyuridine	41.23	2	11738067 (1)
phosphatidylinositol	38.75	4	12939297 (2), 10229195 (1), 11010972 (1)
[alcl]	37.94	1	12153002 (1)
pd 98,059	36.76	10	10906152 (2), 11027833 (1), 19037990 (1), 15298730 (1) (see all 8)
lipofectamine	36.56	5	16842750 (1), 18662588 (1)
epoxomicin	35.90	2	15588951 (2)
thymidine	30.16	4	11079678 (2), 11688513 (1), 12502791 (1)
wortmannin	26.23	4	15588951 (1), 12918102 (1), 18385518 (1), 16479173 (1)

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5 PharmGKB drug compound relationships for CDKN1B gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
docetaxel	FA	14578462
gemcitabine	FA	14578462
pravastatin	FA	10477139
tamoxifen	FA	12907235
trastuzumab	FA	14578462

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN1B)
		Millipore RNAi Products for the Analysis of CDKN1B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDKN1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004064

Sigma-Aldrich siRNA and siRNA Panels for CDKN1B

Sigma-Aldrich shRNA Panels and shRNA for CDKN1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004064

REFSEQ mRNAs for CDKN1B gene:

NM_004064.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004064

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004064
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004064
                                 untagged cDNA clone in CMV expression vector: NM_004064

Additional cDNA sequence:

AB451291.1 AB451423.1 AF247551.1 AJ616234.1 AK298335.1 AK312461.1 AY004255.1 BC001971.1

BT019553.1 BT019554.1 CR457399.1 CR592928.1 U10906.1

13 DOTS entries:

DT.417848 DT.91687599 DT.92038526 DT.100820961 DT.95238381 DT.95374074 DT.100820955 DT.100820956

DT.121171409 DT.95374076 DT.101970489 DT.121171413 DT.95374072

24/236 AceView cDNA sequences (see all 236 ):

AA563693 BM055406 CB158193 NM_004064 AI284117 AA897321 AA506275 CA337570

AI093778 CB216548 AA749161 H13167 AA429206 AI339337 BG928753 AI419631

AA988214 CR592928 BQ029289 CA450020 U10906 AA614403 R81658 AI201163

highest scoring ESTs for CDKN1B:

AI680672 AA062552 AA063159 AA128541 AA172029 AA172264 AA180797 AA180937 AA192725 AA206836

Unigene Cluster for CDKN1B:

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Hs.238990 [show with all ESTs]

Unigene Representative Sequence: NM_004064

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000228872 ENST00000396340

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDKN1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDKN1B

¹ / ² / ³

6 probe-sets matching CDKN1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52535_s_at²^{, 3}	U95-C	1	1.00	1.00	0.87	1.46	AI680672	1.00	1.00	1.00	1
33848_r_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.80	U10906	0.80	1.00	0.91	1
33847_s_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.19	U10906	0.80	1.00	0.91	1
2034_s_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.57	U10906	0.80	1.00	0.91	1
209112_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001971	0.80	1.00	0.91	1
209112_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTGTGCAT

SOURCE GeneReport for Unigene cluster: Hs.238990
Expression variation in blood from EXPOLDB for CDKN1B
UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in
liver and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDKN1B gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDKN1B¹	--	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	89.56(n) 90.4(a)	403429 NM_001002957.1 NP_001002957.1
chimpanzee (Pan troglodytes)	CDKN1B¹	--	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	99.38(n) 99.38(a)	466947 XM_522347.2 XP_522347.2
cow (Bos taurus)	CDKN1B¹	--	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	90.24(n) 90.91(a)	512613 XM_590159.3 XP_590159.3
rat (Rattus norvegicus)	Cdkn1b¹	--	cyclin-dependent kinase inhibitor 1B	87.59(n) 87.24(a)	83571 NM_031762.2 NP_113950.2
mouse (Mus musculus)	Cdkn1b^{1, 5}	6 (62.00 cM)⁵	cyclin-dependent kinase inhibitor 1B^{1, 5}	87.24(n)¹ 87.76(a)¹	12576¹ NM_009875.3¹ NP_034005.2¹ AA408329⁵ AI843786⁵ (see all 19)

About this table Species with no ortholog for CDKN1B

ENSEMBL Gene Tree for CDKN1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDKN1B gene

CDKN1C² CDKN1A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/51 NCBI SNPs in CDKN1B are shown (see all 51 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs34330^1,2	A,C,F,H	12761962(+)	`CGGGCC/TGCGTA`	1	--	ut5¹ ese³		18	NA NS EU EA WA MN CSAM	1716
	rs7330^1,2	A,C,F,H	12766184(+)	`TTTTTA/CAAGGA`	1	--	ut3¹ ese³		12	MN EA WA NS CSAM	1416
	rs3093728^1,2	C,F,H	12761775(+)	`CTCTCC/GGCTTG`	1	--	ut5¹ ese³		5	NS EU WA	762
	rs4251697^1,2	C,F,H	12765729(+)	`ACACTG/AGCTAA`	1	--	ut3¹ ese³		6	NS EU EA WA	774
	rs2066827^1,2	C,F,H	12762366(+)	`GGATGT/GCAGCG`	1	G/V	mis¹		23	NA MN NS CSAM EA EU WA	2316
	rs3759217^1,2	C,F,H	12759719(+)	`CAAGAC/TAGCTG`	1	--	ng5¹		12	EA NA EU WA	2460
	rs2066828^1,2	C,F,H	12762083(+)	`TGGAGC/TGGATG`	1	R/W	mis¹ ese³		13	NA NS MN EA WA CSAM	1510
--	rs4251698^1,2	C,F	12765838(+)	`TTTTTT/AAAAAA`	1	--	ut3¹		2	NS	352
--	rs4251696^1,2	C,F	12765409(+)	`AATGAT/CCTGCC`	1	--	ut3¹		2	NS	340
	rs10237^1,2	C,F	12766272(-)	`TTTTCC/AATACA`	1	--	ut3¹ ese³		6	MN CSAM EA	592

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HapMap Linkage Disequilibrium images for CDKN1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600778 disorders: 610755

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4)

[MIM:610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the

thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2

10/96 Novoseek disease relationships for CDKN1B gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	80.16	39	12783864 (2), 9083081 (2), 16740772 (2), 8916935 (1) (see all 35)
tumors	68.56	418	12605366 (8), 10329035 (6), 19293259 (5), 10559792 (5) (see all 99)
cancer	60.79	113	9683802 (3), 11266285 (2), 19082479 (2), 10404130 (2) (see all 76)
aggressiveness	56.59	12	10223564 (2), 9864434 (1), 10514396 (1), 15073847 (1) (see all 11)
lip squamous cell carcinoma	53.34	3	14662421 (2), 15743689 (1)
carcinoma squamous cell	53.04	35	11854065 (2), 15645120 (2), 9683778 (2), 12530030 (2) (see all 28)
multiple endocrine neoplasia type 1	52.92	5	17613552 (1), 18673462 (1), 17299066 (1), 17803708 (1)
carcinoma	51.79	60	18036045 (5), 9426067 (5), 12150617 (3), 9466585 (3) (see all 30)
multiple endocrine neoplasia	51.32	8	17961654 (1), 18710468 (1), 17097557 (1), 17613552 (1) (see all 5)
prostate cancer	50.42	70	15265403 (4), 14960249 (3), 17070313 (3), 9458103 (3) (see all 36)

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2 PharmGKB disease relationships for CDKN1B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	FA	14578462
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

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Human Gene Mutation Database: CDKN1B
Genetic Association Database: CDKN1B
Human Genome Epidemiology Navigator: CDKN1B (34 documents)
Tumor Gene Database: CDKN1B

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1227 PubMed articles for CDKN1B gene (see all 1227 ):

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. (PubMed id 8033212)^{1, 2, 3, 4} Polyak K.... Massague J. (1994)
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)^{1, 3, 4} Fujita N....Tsuruo T. (2002)
The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PubMed id 15627896)^{1, 3, 6} Schondorf T....Hoopmann M. (2004)
A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction. (PubMed id 15061869)^{1, 3, 6} Gonzalez P....Andres V. (2004)
Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. (PubMed id 7882309)^{1, 3, 4} Pietenpol J.A.... Rowley J.D. (1995)
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. (PubMed id 17254966)^{3, 4} Grimmler M....Hengst L. (2007)
Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans. (PubMed id 17030811)^{3, 4} Pellegata N.S.... Atkinson M.J. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer. (PubMed id 15026335)^{3, 6} Chang B.L....Xu J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1027	HGNC: 1785	AceView: CDKN1B	Ensembl:ENSG00000111276	euGenes: HUgn1027
ECgene: CDKN1B	H-InvDB: CDKN1B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDKN1B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn1b/

Licensable Technologies for CDKN1B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CDKN1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDKN1B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDKN1B)
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	Chimera RNAi (CDKN1B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDKN1B (p27Kip1)

	Recombinant Proteins (Tumour suppressors, p27 KIP 1)
	Antibodies (Tumour suppressors, p27 KIP 1)

Search OriGene for CDKN1B

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDKN1B

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CDKN1B Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for CDKN1B

Summaries
for CDKN1B

Genomic Location
for CDKN1B

Proteins
for CDKN1B

Protein Domains/
Families
for CDKN1B

Gene Function
for CDKN1B

Pathways & Interactions
for CDKN1B

Drugs & Compounds
for CDKN1B

Transcripts
for CDKN1B

Expression
for CDKN1B

Orthologs
for CDKN1B

Paralogs
for CDKN1B

SNPs/Variants
for CDKN1B

Disorders & Mutations
for CDKN1B

Medical News
for CDKN1B

Publications
for CDKN1B

Search for CDKN1B

Genome Databases showing CDKN1B

Other Databases showing CDKN1B

Specialized Databases showing CDKN1B

Licensable Technologies
for CDKN1B

Services
for CDKN1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDKN1B Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor CDKN1B

Summariesfor CDKN1B

Genomic Locationfor CDKN1B

Proteinsfor CDKN1B

Protein Domains/Familiesfor CDKN1B

Gene Functionfor CDKN1B

Pathways & Interactionsfor CDKN1B

Drugs & Compoundsfor CDKN1B

Transcriptsfor CDKN1B

Expression for CDKN1B

Orthologsfor CDKN1B

Paralogsfor CDKN1B

SNPs/Variantsfor CDKN1B

Disorders & Mutationsfor CDKN1B

Medical Newsfor CDKN1B

Publicationsfor CDKN1B

Search for CDKN1B

Genome Databases showing CDKN1B

Other Databases showing CDKN1B

Specialized Databases showing CDKN1B

Licensable Technologiesfor CDKN1B

Servicesfor CDKN1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDKN1B

Summaries
for CDKN1B

Genomic Location
for CDKN1B

Proteins
for CDKN1B

Protein Domains/
Families
for CDKN1B

Gene Function
for CDKN1B

Pathways & Interactions
for CDKN1B

Drugs & Compounds
for CDKN1B

Transcripts
for CDKN1B

Expression
for CDKN1B

Orthologs
for CDKN1B

Paralogs
for CDKN1B

SNPs/Variants
for CDKN1B

Disorders & Mutations
for CDKN1B

Medical News
for CDKN1B

Publications
for CDKN1B

Licensable Technologies
for CDKN1B

Services
for CDKN1B