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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDKN1B Gene

protein-coding   GIFtS: 72
GCID: GC12P012867

Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1)1 2     P27KIP12
KIP12 3 5     Cyclin-Dependent Kinase Inhibitor 1B2
CDKN42 5     Cyclin-Dependent Kinase Inhibitor P273
MEN42 5     p27Kip13
MEN1B2     

External Ids:    HGNC: 17851   Entrez Gene: 10272   Ensembl: ENSG000001112767   OMIM: 6007785   UniProtKB: P465273   

Export aliases for CDKN1B gene to outside databases

Previous GC identifers: GC12P012597 GC12P013015 GC12P012768 GC12P012761 GC12P012639


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN1B Gene:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor
CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes,
and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its
CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular
transition from quiescence to the proliferative state. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDKN1B Gene: 
CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)) is a protein-coding gene. Diseases associated with CDKN1B include mature t-cell and nk-cell neoplasm, and blastic plasmacytoid dendritic cell, and among its related super-pathways are G1-S Phase Transition and Mitotic G1-G1/S phases. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein phosphatase binding. An important paralog of this gene is CDKN1C.

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and
cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly,
stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin
type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry

Gene Wiki entry for CDKN1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKN1B gene promoter:
         AP-1   ATF-2   MyoD   GATA-1   FOXO4   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKN1B promoter sequence
   Search SABiosciences Chromatin IP Primers for CDKN1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1-p12   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.1-p12

CDKN1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P012867:  view genomic region     (about GC identifiers)

Start:
12,867,992 bp from pter      End:
12,875,305 bp from pter
Size:
7,314 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527 (See protein sequence)
Recommended Name: Cyclin-dependent kinase inhibitor 1B  
Size: 198 amino acids; 22073 Da
Subunit: Forms a ternary compex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is
inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome
complex; the interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear
import and degradation of phosphorylated CDKN1B. Interacts with CCND1 and SNX6 (By similarity). Interacts
(Thr-198-phosphorylated form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB
nor YWHAZ; the interaction with YWHAQ results in translocation to the cytoplasm. Interacts with AKT1 and LYN; the
interactions lead to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest.
Interacts (unphosphorylated form) with CDK2. Forms a ternary complex, cyclin D/CDK4/CDKN1B. Interacts
(phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction is required for cyclin D/CDK4 complex assembly,
induces nuclear translocation and activates the CDK4 kinase activity. Interacts with GRB2. Interacts with PIM1.
Identified in a complex with SKP1, SKP2 and CKS1B. Interacts with UHMK1; the interaction leads to cytoplasmic
mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts also with CDK1
Subcellular location: Nucleus. Cytoplasm. Endosome (By similarity). Note=Nuclear and cytoplasmic in quiescent
cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes
cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the
cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the
nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal
degradation (By similarity)
Miscellaneous: Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial
tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate
3 PDB 3D structures from and Proteopedia for CDKN1B:
1H27 (3D)        1JSU (3D)        2AST (3D)    
Secondary accessions: Q16307 Q5U0H2 Q9BUS6

Explore the universe of human proteins at neXtProt for CDKN1B: NX_P46527

Explore proteomics data for CDKN1B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is
    the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein
    stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain
    cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is
    required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein
    ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by
    PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88
    and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues
    by G-CSF
  • UniProtKB: Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus,
    by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing
    SCF(SKP2)-like complex; leads to its degradation
  • UniProtKB: Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46527

  • CDKN1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDKN1B Protein Expression
    REFSEQ proteins: NP_004055.1  
    ENSEMBL proteins: 
     ENSP00000228872   ENSP00000379629   ENSP00000407597  
    Reactome Protein details: P46527
    Human Recombinant Protein Products for CDKN1B: 
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    Novus Biologicals CDKN1B Proteins
    Novus Biologicals CDKN1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CDKN1B
    Cloud-Clone Corp. Proteins for CDKN1B 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11800646
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA12093740
    GO:0005768endosome IEA--
    GO:0005829cytosol TAS--

    CDKN1B for ontologies           About GeneDecksing



    CDKN1B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN1B
    R&D Systems Antibodies for CDKN1B (p27/Kip1)
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    Abcam antibodies for CDKN1B
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    ThermoFisher Antibody for CDKN1B
    LSBio Antibodies in human, mouse, rat for CDKN1B 

    Assay Products for CDKN1B: 
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for CDKN1B (p27Kip1)
    Enzo Life Sciences assays for CDKN1B
    Cloud-Clone Corp. ELISAs for CDKN1B 
    Cloud-Clone Corp. CLIAs for CDKN1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003175 CDI

    Graphical View of Domain Structure for InterPro Entry P46527

    ProtoNet protein and cluster: P46527

    1 Blocks protein domain: IPB003175 Cyclin-dependent kinase inhibitor

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Domain: A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity
    Similarity: Belongs to the CDI family


    CDKN1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN1B_HUMAN, P46527
    Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and
    cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly,
    stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin
    type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry
    Induction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cells
    progress toward S-phase

         Genatlas biochemistry entry for CDKN1B:
    cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and in the cellular
    response after DNA damage in cell cycle exit in megacaryocyte,regulator of cell cycle,critical terminal effector
    of signal transduction pathways that control cell differentiation,overexpressed with CCND3 in agressive B cell
    lymphomas,underexpressed in the development and progression of oral squamous cell carcinoma and in
    thyroid,colon,breast,prostate and superficial bladder carcinomas,deleted in leukemias and other cancers with poor
    prognosis (pancreatic adenocarcinomas)degraded by proteasomes in gliomas

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IEA--
    GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activity TAS8033212
    GO:0005515protein binding IPI12082530
    GO:0008656contributes to cysteine-type endopeptidase activator activity involved in apoptotic process IDA19266349
    GO:0019903protein phosphatase binding IPI19838216
         
    CDKN1B for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDKN1B:
     Cell division defect  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Increased cell number in G2M,  

         15/24 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Cdkn1b) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    CDKN1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDKN1B: Cdkn1btm1Kin Cdkn1btm1Ako Cdkn1btm2.1Mlf Cdkn1btm3Mlf Cdkn1btm1Mlf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDKN1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDKN1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN1B 

    miRNA
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    miRTarBase miRNAs that target CDKN1B:
    hsa-mir-192 (MIRT005064), hsa-mir-181a (MIRT004554), hsa-mir-222 (MIRT000131), hsa-mir-221 (MIRT000137), hsa-mir-128 (MIRT004417), hsa-mir-190 (MIRT005066), hsa-mir-24 (MIRT005063), hsa-mir-218 (MIRT005067), hsa-mir-196a (MIRT005065)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN1B
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN1B (see all 60):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-429 hsa-miR-488 hsa-miR-105 hsa-miR-3171 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidCDKN1B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDKN1B About   (see all 67)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    5Glioma
    Prostate cancer0.39
    Signaling Pathways in Glioblastoma0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for CDKN1B (see all 8)
        Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Role of SCF complex in cell cycle regulation
    Development Role of Activin A in cell differentiation and proliferation
    Development Thrombopoietin-regulated cell processes
    Cell cycle ESR1 regulation of G1/S transition

    1 R&D Systems Pathway for CDKN1B
        Akt Signaling Pathway

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN1B (see all 13)
        ErbB2-ErbB3 Heterodimers
    HGF Pathway
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling

    1 Cell Signaling Technology (CST) Pathway for CDKN1B
        Cell Cycle / Checkpoint Control

    5/8 GeneGo (Thomson Reuters) Pathways for CDKN1B (see all 8)
        Signal transduction AKT signaling
    Development Thrombopoietin-regulated cell processes
    Development Role of Activin A in cell differentiation and proliferation
    Cell cycle Role of SCF complex in cell cycle regulation
    Development Thrombopoetin signaling via JAK-STAT pathway

    5/27 BioSystems Pathways for CDKN1B (see all 27)
        DNA damage response
    Senescence and Autophagy
    Cell cycle
    G1 to S cell cycle control
    DNA damage response (only ATM dependent)


    5/52        Reactome Pathways for CDKN1B (see all 52)
        Orc1 removal from chromatin
    Signaling by EGFR in Cancer
    G1/S DNA Damage Checkpoints
    S Phase
    Downstream signal transduction

    1 PharmGKB Pathway for CDKN1B
        Celecoxib Pathway, Pharmacodynamics

    5/14         Kegg Pathways  (Kegg details for CDKN1B) (see all 14):
        ErbB signaling pathway
    HIF-1 signaling pathway
    Cell cycle
    PI3K-Akt signaling pathway
    Hepatitis B


    CDKN1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/182 Interacting proteins for CDKN1B (P465271, 2, 3 ENSP000002288724) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCND2P302792, 3, ENSP000002612544MINT-67874 I2D: score=6 STRING: ENSP00000261254
    ARHGDIAP525652, 3, ENSP000002693214MINT-63858 I2D: score=5 STRING: ENSP00000269321
    CCNA2P202481, 3, ENSP000002740264EBI-519280,EBI-457097 I2D: score=5 STRING: ENSP00000274026
    COPS5Q929051, 3, ENSP000003505124EBI-519280,EBI-594661 I2D: score=5 STRING: ENSP00000350512
    GRB2P629932, 3, ENSP000003390074MINT-7219650 I2D: score=5 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS8033212
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006813potassium ion transport IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA19266349

    CDKN1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDKN1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    10/102 Novoseek inferred chemical compound relationships for CDKN1B gene (see all 102)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 55.1 8 15588951 (2), 12242656 (1), 19443725 (1), 11709727 (1) (see all 7)
    leptomycin b 50.2 9 15735731 (3), 16842750 (1), 11889117 (1)
    eb 1089 49.4 6 12586749 (3), 16340750 (2), 10640426 (1)
    1,25 dihydroxy vitamin d3 44.6 17 9697881 (5), 9652739 (2), 16883603 (1), 16322758 (1) (see all 8)
    mg 132 43.8 2 15173011 (1), 12646415 (1)
    ciglitazone 43.5 9 15763423 (6), 15951157 (1)
    trastuzumab 43.1 20 15611642 (6), 14648698 (3), 15173011 (2), 15642702 (1) (see all 7)
    bromodeoxyuridine 43 2 11738067 (1)
    mimosine 42.6 8 10623466 (4), 10530763 (1), 15855174 (1), 15923641 (1)
    rapamycin 41.5 14 20097763 (3), 8895523 (2), 12393532 (1), 16862180 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about CDKN1B / CDN1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDKN1B gene: 
    NM_004064.3  

    Unigene Cluster for CDKN1B:

    Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
    Hs.238990  [show with all ESTs]
    Unigene Representative Sequence: NM_004064
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477087 ENST00000228872(uc001rat.2) ENST00000396340 ENST00000442489

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB451291.1 AB451423.1 AF247551.1 AJ616234.1 AK298335.1 AK312461.1 AY004255.1 BC001971.1 
    BT019553.1 BT019554.1 CR457399.1 U10906.1 

    13 DOTS entries:

    DT.417848  DT.100820961  DT.95238381  DT.95374074  DT.100820955  DT.100820956  DT.101970489  DT.121171409 
    DT.121171413  DT.91687599  DT.95374072  DT.95374076  DT.92038526 

    24/236 AceView cDNA sequences (see all 236):

    NM_004064 BG928753 R81658 BM055406 AI201163 CR592928 H13167 AA749161 
    BQ029289 BF221469 AI339337 AI380694 BF061836 CA337570 AA614403 AI284117 
    AA897321 U10906 CA450020 H88763 AA563693 AI419631 AW022687 AA988214 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDKN1B expression in normal human tissues (normalized intensities)      CDKN1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTGCAT
    CDKN1B Expression
    About this image


    CDKN1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer

    See CDKN1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDKN1B

    SOURCE GeneReport for Unigene cluster: Hs.238990

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN1B (see all 15): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN1B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn1b1 , 5 cyclin-dependent kinase inhibitor 1B1, 5 87.24(n)1
    87.76(a)1
      6 (65.77 cM)5
    125761  NM_009875.41  NP_034005.21 
     1349204015 
    chicken
    (Gallus gallus)
    Aves CDKN1B1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) 76.6(n)
    68.69(a)
      374106  NM_204256.2  NP_989587.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDKN1B6
    Uncharacterized protein
    44(a)
    1 ↔ 1
    GL343579.1(387419-392046)
    zebrafish
    (Danio rerio)
    Actinopterygii BC056746.12   -- 76.24(n)    BC056746.1 


    ENSEMBL Gene Tree for CDKN1B (if available)
    TreeFam Gene Tree for CDKN1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDKN1B gene
    CDKN1C2  CDKN1A2  
    3 SIMAP similar genes for CDKN1B using alignment to 6 protein entries:     CDN1B_HUMAN (see all proteins):
    p27 kip1    CDKN1C    CDKN1A

    CDKN1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/194 SNPs in CDKN1B are shown (see all 194)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178321,2
    Cpathogenic112740089(+) CGAGTA/GGCAAG 2 * W stg10--------
    VAR_0644294
    ----see VAR_0644292 P L mis40--------
    rs362282031,2
    C--12737489(+) ACCCC-/TGTCCT 1 -- us2k10--------
    rs37592171,2
    C,F,H--12737540(+) CAAGAC/TAGCTG 1 -- us2k127Minor allele frequency- T:0.07EA NA NS CSA WA 4394
    rs1413280631,2
    --12737601(+) ACCCAC/GGGCCT 1 -- us2k10--------
    rs1149625571,2
    F--12737760(+) CTAGTC/TCTGAC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs357567411,2
    C,F--12737789(-) CCAGGG/AACATG 1 -- us2k15Minor allele frequency- A:0.08NA CSA WA 244
    rs1470197341,2
    --12737831(+) CGTGGC/TAAAAA 1 -- us2k10--------
    rs1381869511,2
    --12738131(+) CCCTGC/TTCATC 1 -- us2k10--------
    rs773882281,2
    C--12738247(+) GACATC/GGTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDKN1B (12867992 - 12875305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDKN1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745567CNV Deletion23290073
    nsv898812CNV Loss21882294
    nsv898813CNV Loss21882294
    nsv898811CNV Gain21882294


    Human Gene Mutation Database (HGMD): CDKN1B
    SABiosciences Cancer Mutation PCR Assays
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    Prostate Cancer
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600778   
    OMIM disorders: 610755  
    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
  • Multiple endocrine neoplasia 4 (MEN4) [MIM:610755]: Multiple endocrine neoplasia (MEN) syndromes are
    inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and
    MEN2. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/170 diseases for CDKN1B (see all 170):    About MalaCards
    mature t-cell and nk-cell neoplasm    blastic plasmacytoid dendritic cell    periampullary adenocarcinoma    multiple endocrine neoplasia type 4
    multiple endocrine neoplasia    familial isolated pituitary adenoma    spindle cell sarcoma    basaloid squamous cell carcinoma
    hypervitaminosis a    cervical adenocarcinoma    acute lymphoblastic leukemia, childhood    papilloma
    pleomorphic carcinoma    cholangiocarcinoma    wermer syndrome    collecting duct carcinoma
    ewing's family of tumors    prolymphocytic leukemia    t-cell prolymphocytic leukemia    parathyroid adenoma

    8 diseases from the University of Copenhagen DISEASES database for CDKN1B:
    Retinoblastoma     Carcinoma     Wermer syndrome     Carney complex
    Leukemia     Breast cancer     Prostate cancer     Adenoma

    CDKN1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for CDKN1B gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 80.4 45 12783864 (2), 9083081 (2), 16740772 (2), 8916935 (1) (see all 40)
    tumors 68.8 455 12605366 (8), 10329035 (6), 19293259 (5), 10559792 (5) (see all 99)
    cancer 61 123 9683802 (3), 11266285 (2), 19082479 (2), 10404130 (2) (see all 82)
    aggressiveness 56.8 15 19866239 (2), 10223564 (2), 9864434 (1), 10514396 (1) (see all 13)
    multiple endocrine neoplasia type 1 56 5 17613552 (1), 18673462 (1), 17299066 (1), 17803708 (1)
    prostate cancer 52.5 71 15265403 (4), 14960249 (3), 17070313 (3), 9458103 (3) (see all 37)
    multiple endocrine neoplasia 51.8 8 17961654 (1), 18710468 (1), 17097557 (1), 17613552 (1) (see all 5)
    carcinoma 51.7 63 18036045 (5), 9426067 (5), 12150617 (3), 9466585 (3) (see all 33)
    carcinoma squamous cell 51.2 35 11854065 (2), 15645120 (2), 9683778 (2), 12530030 (2) (see all 28)
    lip squamous cell carcinoma 50.6 3 14662421 (2), 15743689 (1)

    Genetic Association Database (GAD): CDKN1B
    Human Genome Epidemiology (HuGE) Navigator: CDKN1B (63 documents)
    Tumor Gene Database (TGDB): CDKN1B

    Export disorders for CDKN1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDKN1B gene, integrated from 9 sources (see all 1592):
    (articles sorted by number of sources associating them with CDKN1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. (PubMed id 8033212)1, 2, 3, 9 Polyak K.... Massague J. (1994)
    2. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2, 9 Fujita N.... Tsuruo T. (2002)
    3. [Association of polymorphisms of p21cip1 and p27kip1 genes with susceptibilities of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma] (PubMed id 16480585)1, 4, 9 Guo W....Zhang J.H. (2006)
    4. Allelic variant at -79 (C>T) in CDKN1B (p27Kip1) c onfers an increased risk of thyroid cancer and alters mRNA levels. (PubMed id 20075119)1, 4, 9 Landa I....Robledo M. (2010)
    5. Detection of gene copy number aberrations in mantle c ell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4, 9 Jardin F....Tilly H. (2009)
    6. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. (PubMed id 17008550)1, 4, 9 Healy J....Sinnett D. (2007)
    7. Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women. (PubMed id 16804901)1, 4, 9 Ma H....Shen H. (2006)
    8. The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PubMed id 15627896)1, 4, 9 Schondorf T....Hoopmann M. (2004)
    9. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4, 9 Goode E.L....Sellers T.A. (2009)
    10. Germline mutations in the CDKN1B gene encoding p27(Kip1) are a rare cause of Multiple Endocrine Neoplasia type 1. (PubMed id 18673462)1, 4, 9 Owens M....Vaidya B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1027 HGNC: 1785 AceView: CDKN1B Ensembl:ENSG00000111276 euGenes: HUgn1027
    ECgene: CDKN1B Kegg: 1027 H-InvDB: CDKN1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDKN1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDKN1B gene:
    Search GeneIP for patents involving CDKN1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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