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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDKN1B Gene

protein-coding GIFtS: 70
GCID: GC12P012867

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Explore 198 diseases affiliated with
CDKN1B via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1)¹ ²		MEN1B²
KIP1¹ ² ³ ⁵		Cyclin-Dependent Kinase Inhibitor 1B²
P27KIP1¹ ²		Cyclin-Dependent Kinase Inhibitor P27³
CDKN4² ⁵		P27Kip1¹
MEN4² ⁵

External Ids:	HGNC: 1785¹	Entrez Gene: 1027²	Ensembl: ENSG00000111276⁷	OMIM: 600778⁵	UniProtKB: P46527³

Export aliases for CDKN1B gene to outside databases

Previous GC identifers: GC12P012597 GC12P013015 GC12P012768 GC12P012761 GC12P012639

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN1B:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21.

The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus

controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent

phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from

quiescence to the proliferative state. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and

cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability,

and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4

complexes depending on its phosphorylation state and/or stoichometry

Gene Wiki entry for CDKN1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDKN1B gene promoter:
AP-1 ATF-2 MyoD GATA-1 FOXO4 FOXO1a c-Jun FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDKN1B promoter sequence

Search SABiosciences Chromatin IP Primers for CDKN1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1-p12 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p13.1-p12

CDKN1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN1B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P012867: view genomic region (about GC identifiers)

Start:	12,867,992 bp from pter	End:	12,875,305 bp from pter
Size:	7,314 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527 (See protein sequence)

Recommended Name: Cyclin-dependent kinase inhibitor 1B

Size: 198 amino acids; 22073 Da

Subunit: Forms a ternary compex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by

CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex; the

interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear import and degradation

of phosphorylated CDKN1B. Interacts with CCND1 and SNX6 (By similarity). Interacts (Thr-198-phosphorylated form) with

14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ

results in translocation to the cytoplasm. Interacts with AKT1 and LYN; the interactions lead to cytoplasmic

mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts (unphosphorylated form) with

CDK2. Forms a ternary complex, cyclin D/CDK4/CDKN1B. Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the

interaction is required for cyclin D/CDK4 complex assembly, induces nuclear translocation and activates the CDK4

kinase activity. Interacts with GRB2. Interacts with PIM1. Identified in a complex with SKP1, SKP2 and CKS1B.

Interacts with UHMK1; the interaction leads to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of

cell cycle arrest. Interacts also with CDK1

Subcellular location: Nucleus. Cytoplasm. Endosome (By similarity). Note=Nuclear and cytoplasmic in quiescent cells.

AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle

progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell

cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on

phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By

similarity)

Miscellaneous: Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial

tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate

3 PDB 3D structures from and Proteopedia for CDKN1B:

1H27 (3D)

1JSU (3D)

2AST (3D)

Secondary accessions: Q16307 Q5U0H2 Q9BUS6

Explore the universe of human proteins at neXtProt for CDKN1B: NX_P46527

Post-translational modifications:

Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the

major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability.

Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines.

The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction

with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation.

Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an

inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is

required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF¹

Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by

SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like

complex; leads to its degradation¹

Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P46527

CDKN1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004055.1

ENSEMBL proteins:

ENSP00000228872 ENSP00000379629 ENSP00000407597

Reactome Protein details: P46527
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for CDKN1B
	Uscn Proteins for CDKN1B

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11800646
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	12093740
GO:0005768	endosome	IEA	--
GO:0005829	cytosol	TAS	--

CDKN1B for ontologies About GeneDecksing

CDKN1B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN1B
	R&D Systems Antibodies for CDKN1B (p27/Kip1)
	R&D Systems Secondary Antibodies, Controls, & Staining Reagents for CDKN1B (p27/Kip1)
	Cell Signaling Technology (CST) Antibodies for CDKN1B (p27Kip1)
	OriGene Antibodies (see all 6): CDKN1B OriGene Custom Antibody Services for CDKN1B
	GenScript Custom Superior Antibodies Services for CDKN1B
	Novus Biologicals CDKN1B Antibodies
	Abcam antibodies for CDKN1B
	Uscn Antibodies for CDKN1B
	ThermoFisher Antibody for CDKN1B

Assay Products for CDKN1B:

	Browse Kits and Assays available from EMD Millipore
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	Enzo Life Sciences assays for CDKN1B
	Uscn ELISAs and CLIAs for CDKN1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDKN1B for domains About GeneDecksing

1 InterPro domain/family:

IPR003175 CDI

Graphical View of Domain Structure for InterPro Entry P46527

ProtoNet protein and cluster: P46527

1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Domain: A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity

Similarity: Belongs to the CDI family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and

cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability,

and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4

complexes depending on its phosphorylation state and/or stoichometry

Induction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cells

progress toward S-phase

Genatlas biochemistry entry for CDKN1B:

cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and in the cellular

response after DNA damage in cell cycle exit in megacaryocyte,regulator of cell cycle,critical terminal effector of

signal transduction pathways that control cell differentiation,overexpressed with CCND3 in agressive B cell

lymphomas,underexpressed in the development and progression of oral squamous cell carcinoma and in

thyroid,colon,breast,prostate and superficial bladder carcinomas,deleted in leukemias and other cancers with poor

prognosis (pancreatic adenocarcinomas)degraded by proteasomes in gliomas

miRNA Products:		miRTarBase miRNAs that target CDKN1B: hsa-mir-192 (MIRT005064), hsa-mir-181a (MIRT004554), hsa-mir-222 (MIRT000131), hsa-mir-221 (MIRT000137), hsa-mir-128 (MIRT004417), hsa-mir-190 (MIRT005066), hsa-mir-24 (MIRT005063), hsa-mir-218 (MIRT005067), hsa-mir-196a (MIRT005065)

		OriGene 3'-UTR Clone: CDKN1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN1B
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN1B (see all 60):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-429 hsa-miR-488 hsa-miR-105 hsa-miR-3171 hsa-miR-890

		SwitchGear 3'UTR luciferase reporter plasmid: CDKN1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKN1B (see all 7) OriGene shRNA RFP: CDKN1B OriGene siRNA: CDKN1B
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: CDKN1B (NM_004064)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN1B

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IEA	--
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	TAS	8033212
GO:0005515	protein binding	IPI	--
GO:0008656	contributes to cysteine-type endopeptidase activator activity involved in apoptotic process	IDA	19266349
GO:0016301	kinase activity	--	--

CDKN1B for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for CDKN1B:

Cell division defect	Decreased influenza A H1N1 (A/	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r
Increased cell number in G2M,

Animal Models:
Mouse knock-outs for CDKN1B: Cdkn1b^tm1Kin Cdkn1b^tm1Ako Cdkn1b^tm2.1Mlf Cdkn1b^tm3Mlf Cdkn1b^tm1Mlf
15/24 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Cdkn1b) (see all 24):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging

CDKN1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/59 super-pathways (see all 59) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/15 pathways (see all 15)
p53-Dependent G1/S DNA damage checkpoint	0.83	Removal of licensing factors from origins	0.68
p53-Dependent G1 DNA Damage Response	0.83	Cyclin E associated events during G1/S transition	0.67
G1/S DNA Damage Checkpoints	0.79	Cyclin A:Cdk2-associated events at S phase entry	0.66
Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75	Synthesis of DNA	0.51

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PIP3 activates AKT signaling	1.00	PI3K/AKT activation	0.97
PI3K/AKT Signaling in Cancer	1.00	GAB1 signalosome	0.96
PI3K events in ERBB2 signaling	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB4 signaling	1.00	Signaling by SCF-KIT	0.72

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	1.00			Cyclin D associated events in G1	0.32
	G1-S Phase Transition	0.67			G1 Phase	0.32

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for CDKN1B (see all 8)

	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle Role of SCF complex in cell cycle regulation
	Development Role of Activin A in cell differentiation and proliferation
	Development Thrombopoietin-regulated cell processes
	Cell cycle ESR1 regulation of G1/S transition

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN1B (see all 13)

	ErbB2-ErbB3 Heterodimers
	HGF Pathway
	Molecular Mechanisms of Cancer
	Calpain Protease Regulates Cellular Mechanics
	TOB in T-Cell Signaling

1 Cell Signaling Technology (CST) Pathway for CDKN1B

Cell Cycle / Checkpoint Control

5/8 GeneGo (Thomson Reuters) Pathways for CDKN1B (see all 8)

	Signal transduction AKT signaling
	Development Thrombopoietin-regulated cell processes
	Development Role of Activin A in cell differentiation and proliferation
	Cell cycle Role of SCF complex in cell cycle regulation
	Development Thrombopoetin signaling via JAK-STAT pathway

5/26 BioSystems Pathways for CDKN1B (see all 26)

	ErbB signaling pathway
	G1 to S cell cycle control
	Oncostatin M Signaling Pathway
	Signaling Pathways in Glioblastoma
	Senescence and Autophagy

5/51 Reactome Pathways for CDKN1B (see all 51)

	Orc1 removal from chromatin
	Signaling by EGFR in Cancer
	G1/S DNA Damage Checkpoints
	S Phase
	Downstream signal transduction

1 PharmGKB Pathway for CDKN1B

Celecoxib Pathway, Pharmacodynamics

5/7 Kegg Pathways (Kegg details for CDKN1B) (see all 7):

	ErbB signaling pathway
	Cell cycle
	Measles
	Pathways in cancer
	Prostate cancer

CDKN1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDKN1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/182 Interacting proteins for CDKN1B (P46527^{1, 2, 3} ENSP00000228872⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 182)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCND2	P30279²^,³, ENSP00000261254⁴	MINT-67874 I2D: score=6 STRING: ENSP00000261254
ARHGDIA	P52565²^,³, ENSP00000269321⁴	MINT-63858 I2D: score=5 STRING: ENSP00000269321
CCNA2	P20248¹^,³, ENSP00000274026⁴	EBI-519280,EBI-457097 I2D: score=5 STRING: ENSP00000274026
COPS5	Q92905¹^,³, ENSP00000350512⁴	EBI-519280,EBI-594661 I2D: score=5 STRING: ENSP00000350512
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-7219650 I2D: score=5 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	8033212
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--

CDKN1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDKN1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDKN1B
10/102 Novoseek chemical compound relationships for CDKN1B gene (see all 102) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ly294002	55.1	8	15588951 (2), 12242656 (1), 19443725 (1), 11709727 (1) (see all 7)
leptomycin b	50.2	9	15735731 (3), 16842750 (1), 11889117 (1)
eb 1089	49.4	6	12586749 (3), 16340750 (2), 10640426 (1)
1,25 dihydroxy vitamin d3	44.6	17	9697881 (5), 9652739 (2), 16883603 (1), 16322758 (1) (see all 8)
mg 132	43.8	2	15173011 (1), 12646415 (1)
ciglitazone	43.5	9	15763423 (6), 15951157 (1)
trastuzumab	43.1	20	15611642 (6), 14648698 (3), 15173011 (2), 15642702 (1) (see all 7)
bromodeoxyuridine	43	2	11738067 (1)
mimosine	42.6	8	10623466 (4), 10530763 (1), 15855174 (1), 15923641 (1)
rapamycin	41.5	14	20097763 (3), 8895523 (2), 12393532 (1), 16862180 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about CDKN1B / CDN1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDKN1B gene:

NM_004064.3

Unigene Cluster for CDKN1B:

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Hs.238990 [show with all ESTs]

Unigene Representative Sequence: NM_004064

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477087 ENST00000228872(uc001rat.2) ENST00000396340 ENST00000442489

miRNA Products:		OriGene 3'-UTR Clone: CDKN1B Browse OriGene MicroRNA Expression Plasmids
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		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN1B (see all 60):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-429 hsa-miR-488 hsa-miR-105 hsa-miR-3171 hsa-miR-890

		SwitchGear 3'UTR luciferase reporter plasmid: CDKN1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN1B

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Additional cDNA sequence:

AB451291.1 AB451423.1 AF247551.1 AJ616234.1 AK298335.1 AK312461.1 AY004255.1 BC001971.1

BT019553.1 BT019554.1 CR457399.1 U10906.1

13 DOTS entries:

DT.417848 DT.100820961 DT.95238381 DT.95374074 DT.100820955 DT.100820956 DT.101970489 DT.121171409

DT.121171413 DT.91687599 DT.95374072 DT.95374076 DT.92038526

24/236 AceView cDNA sequences (see all 236):

BG928753 AW022687 AI419631 AA988214 AA614403 AW023852 BF221469 H13167

AI339337 CA337570 CA450020 U10906 AI671934 BM055406 AA749161 AA897321

AA506275 BQ029289 AI093778 AI380694 AI284117 AI201163 R81658 CR592928

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDKN1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTGCAT

About this image

CDKN1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Muller Glia Cells

Selective marker (cell-identifying gene)

Muller Glia, Retina

Kidney

Podocyte Layer

Podocytes

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDKN1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDKN1B

SOURCE GeneReport for Unigene cluster: Hs.238990

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN1B (see all 15):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Leukemia in human mouse rat

Autophagy in human mouse rat

Liver Cancer in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDKN1B gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdkn1b^{1 , 5}	cyclin-dependent kinase inhibitor 1B^{1, 5}	87.24(n)¹ 87.76(a)¹		6 (65.77 cM)⁵ 12576¹ NM_009875.4¹ NP_034005.2¹ 134920401⁵
chicken (Gallus gallus)	Aves	CDKN1B¹	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	76.6(n) 68.69(a)		374106 NM_204256.2 NP_989587.1
lizard (Anolis carolinensis)	Reptilia	CDKN1B⁶	--	48(a)	1 ↔ 1	GL343579.1(387419-392046)
zebrafish (Danio rerio)	Actinopterygii	BC056746.1²	--	76.24(n)		BC056746.1

ENSEMBL Gene Tree for CDKN1B (if available)
TreeFam Gene Tree for CDKN1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDKN1B gene

CDKN1C² CDKN1A²

3 SIMAP similar genes for CDKN1B using alignment to 6 protein entries: CDN1B_HUMAN (see all proteins):

p27 kip1 CDKN1C CDKN1A

CDKN1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121917832^1,2	C	pathogenic	12640591(+)	`CGAGTA/GGCAAG`	2	* W	stg¹		0	--	--	--	--
rs36228203^1,2	C,	--	12637993(+)	`ACCCC-/TGTCCT`	1	--	us2k¹		0	--	--	--	--
rs35756741^1,2	C,F,	--	12638293(-)	`CCAGGG/AACATG`	1	--	us2k¹		5		NA CSA WA	244
rs201923582^1,2	C	--	12639137(+)	`TTTTTG/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs11055028^1,2	C	--	12639301(+)	`TTCTGA/GGTTAA`	1	--	us2k¹		0	--	--	--	--
rs248743^1,2	C,F,	--	12639378(+)	`CCAGCC/TCCCCC`	1	--	us2k¹		3		NA WA	122
rs36228499^1,2	C,	--	12639527(-)	`TCCTCG/TCCCGG`	1	--	us2k¹		5		NA WA EA	362
rs36228495^1,2	C	--	12639679(+)	`GCAGGC/TTTGTT`	1	--	us2k¹		1		CSA	2
rs3093728^1,2	C,F,H,	--	12640099(+)	`CTCTCC/GGCTTG`	1	--	ut5¹ ese³		5		NS	762
rs2066828^1,2	C,F	--	12640407(+)	`TGGAGC/TGGATG`	2	R W	mis¹ ese³		12		NA NS MN	1218

HapMap Linkage Disequilibrium report for CDKN1B (12867992 - 12875305 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDKN1B: --
Human Gene Mutation Database (HGMD): CDKN1B

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing CDKN1B:

Oncogenes & Tumor Suppressor Genes 384HC

Prostate Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKN1B

DNA2.0 Custom Variant and Variant Library Synthesis for CDKN1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDKN1B for disorders           About GeneDecksing

OMIM gene information: 600778
OMIM disorders: 610755
UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrine

neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic

overlap of both MEN1 and MEN2

20/198 diseases for CDKN1B (see all 198): About MalaCards

blastic plasmacytoid dendritic cell multiple endocrine neoplasia monoclonal gammopathy of undetermined significance mature t-cell and nk-cell neoplasm

multiple endocrine neoplasia type 4 anaplastic large cell lymphoma diffuse large b-cell lymphoma squamous cell carcinoma

central nervous system lymphoma fallopian tube carcinoma non-small cell lung carcinoma collecting duct carcinoma

b-cell lymphomas hypervitaminosis a parathyroid adenoma basaloid squamous cell carcinoma

carcinoma testicular germ cell tumor cervical squamous cell carcinoma clear cell renal cell carcinoma

8 diseases from the University of Copenhagen DISEASES database for CDKN1B:

Retinoblastoma Carcinoma Wermer syndrome Carney complex

Leukemia Breast cancer Prostate cancer Adenoma

10/96 Novoseek disease relationships for CDKN1B gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	80.4	45	12783864 (2), 9083081 (2), 16740772 (2), 8916935 (1) (see all 40)
tumors	68.8	455	12605366 (8), 10329035 (6), 19293259 (5), 10559792 (5) (see all 99)
cancer	61	123	9683802 (3), 11266285 (2), 19082479 (2), 10404130 (2) (see all 82)
aggressiveness	56.8	15	19866239 (2), 10223564 (2), 9864434 (1), 10514396 (1) (see all 13)
multiple endocrine neoplasia type 1	56	5	17613552 (1), 18673462 (1), 17299066 (1), 17803708 (1)
prostate cancer	52.5	71	15265403 (4), 14960249 (3), 17070313 (3), 9458103 (3) (see all 37)
multiple endocrine neoplasia	51.8	8	17961654 (1), 18710468 (1), 17097557 (1), 17613552 (1) (see all 5)
carcinoma	51.7	63	18036045 (5), 9426067 (5), 12150617 (3), 9466585 (3) (see all 33)
carcinoma squamous cell	51.2	35	11854065 (2), 15645120 (2), 9683778 (2), 12530030 (2) (see all 28)
lip squamous cell carcinoma	50.6	3	14662421 (2), 15743689 (1)

Genetic Association Database (GAD): CDKN1B
Human Genome Epidemiology (HuGE) Navigator: CDKN1B (63 documents)
Tumor Gene Database (TGDB): CDKN1B

Export disorders for CDKN1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDKN1B gene, integrated from 9 sources (see all 1552):
(articles sorted by number of sources associating them with CDKN1B)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. (PubMed id 8033212)^{1, 2, 3, 9} Polyak K.... Massague J. (1994)
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)^{1, 2, 9} Fujita N.... Tsuruo T. (2002)
The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PubMed id 15627896)^{1, 4, 9} Schondorf T....Hoopmann M. (2004)
A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction. (PubMed id 15061869)^{1, 4, 9} Gonzalez P....Andres V. (2004)
Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. (PubMed id 7882309)^{1, 2, 9} Pietenpol J.A.... Rowley J.D. (1995)
Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. (PubMed id 21423214)^{1, 2} Jakel H.... Hengst L. (2011)
A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization. (PubMed id 20824794)^{1, 2} Molatore S.... Pellegata N.S. (2010)
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)^{1, 2} Morishita D.... Fujita N. (2008)
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. (PubMed id 17254966)^{1, 2} Grimmler M.... Hengst L. (2007)
Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans. (PubMed id 17030811)^{1, 2} Pellegata N.S.... Atkinson M.J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1027	HGNC: 1785	AceView: CDKN1B	Ensembl:ENSG00000111276	euGenes: HUgn1027
ECgene: CDKN1B	Kegg: 1027	H-InvDB: CDKN1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDKN1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDKN1B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn1b/

Intellectual Property for CDKN1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDKN1B gene:
Search GeneIP for patents involving CDKN1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CDKN1B Gene

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

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Lymphoblastic Leukemia Acute Childhood
Lymphoma Large Cell
Retinoblastoma
Pituitary Tumors
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aggressiveness
ADENOCARCINOMA LUNG
COLON CARCINOMA
PARATHYROID ADENOMA
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OVARIAN CARCINOMA
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solid tumor
Carcinoma Squamous Cell
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THYROID CARCINOMA
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CDKN1B Gene

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

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