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CDKN1A Gene

protein-coding   GIFtS: 73
GCID: GC06P037308

Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1)


(Previous symbol: CDKN1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1)1 2     Cyclin-Dependent Kinase Inhibitor 12
CDKN11 2 3 5     DNA Synthesis Inhibitor2
CIP12 3 5     Melanoma Differentiation Associated Protein 62
WAF12 3 5     p21CIP12
CAP202 3     Wild-Type P53-Activated Fragment 12
MDA-62 3     MDA63
SDI12 3     PIC13
CDK-Interacting Protein 12 3     Melanoma Differentiation-Associated Protein 63
P212     p213
CDK-Interaction Protein 12     

External Ids:    HGNC: 17841   Entrez Gene: 10262   Ensembl: ENSG000001247627   OMIM: 1168995   UniProtKB: P389363   
ORGUL members:         

Export aliases for CDKN1A gene to outside databases

Previous GC identifers: GC06P036648 GC06P036693 GC06P036754 GC06P036645 GC06P036364 GC06P036649 GC06P036761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKN1A Gene:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the
activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1.
The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein
mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein
can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a
regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically
cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the
execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for
this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CDKN1A Gene:
CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)) is a protein-coding gene. Diseases associated with CDKN1A include bladder transitional cell carcinoma, and thoracic cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and protein complex binding. An important paralog of this gene is CDKN1C.

UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular
proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing
phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in
the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At
higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex

Gene Wiki entry for CDKN1A (P21) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKN1A gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CDKN1A promoter sequence
   Search Chromatin IP Primers for CDKN1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKN1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.1

CDKN1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037308:  view genomic region     (about GC identifiers)

Start:
36,644,237 bp from pter      End:
36,655,116 bp from pter
Size:
10,880 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936 (See protein sequence)
Recommended Name: Cyclin-dependent kinase inhibitor 1  
Size: 164 amino acids; 18119 Da
Subunit: Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1
facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts
with PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its
N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear
translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E
inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA
repair. Interacts with PIM1
Sequence caution: Sequence=AAB59559.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAB59560.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for CDKN1A:
1AXC (3D)        2ZVV (3D)        2ZVW (3D)    
Secondary accessions: Q14010 Q6FI05 Q9BUT4

Explore the universe of human proteins at neXtProt for CDKN1A: NX_P38936

Explore proteomics data for CDKN1A at MOPED

Post-translational modifications: 

  • Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by
    GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A
    stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A
    to the cytoplasm and enhanced CDKN1A protein stability1
  • Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by
    the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV
    irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is
    PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the
    PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation
    by the proteasome pathway1
  • Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163.
    Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity)1
  • Ubiquitination2 at Lys75
  • Modification sites at PhosphoSitePlus

  • See CDKN1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000380.1  NP_001207706.1  NP_001207707.1  NP_510867.1  

    ENSEMBL proteins: 
     ENSP00000244741   ENSP00000362815   ENSP00000409259   ENSP00000384849  
    Reactome Protein details: P38936

    CDKN1A Human Recombinant Protein Products:

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    Novus Biologicals CDKN1A Proteins
    Novus Biologicals CDKN1A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDKN1A
    Cloud-Clone Corp. Proteins for CDKN1A

    CDKN1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN1A
    R&D Systems Antibodies for CDKN1A (p21/CIP1/CDKN1A)
    Cell Signaling Technology (CST) Antibodies for CDKN1A  (p21Cip1)
    OriGene Antibodies for CDKN1A
    OriGene Custom Antibody Services for CDKN1A
    Novus Biologicals CDKN1A Antibodies
    Abcam antibodies for CDKN1A
    Cloud-Clone Corp. Antibodies for CDKN1A
    ThermoFisher Antibody for CDKN1A
    LSBio Antibodies in human, mouse, rat for CDKN1A

    CDKN1A Assay Products:

    EMD Millipore Kits and Assays for the Analysis of CDKN1A
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for CDKN1A (p21Cip1)
    Enzo Life Sciences assays for CDKN1A
    Cloud-Clone Corp. ELISAs for CDKN1A
    Cloud-Clone Corp. CLIAs for CDKN1A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003175 CDI

    Graphical View of Domain Structure for InterPro Entry P38936

    ProtoNet protein and cluster: P38936

    1 Blocks protein domain: IPB003175 Cyclin-dependent kinase inhibitor

    UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
    Domain: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex:
    while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading
    to its ubiquitination
    Domain: The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex
    Similarity: Belongs to the CDI family


    CDKN1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDN1A_HUMAN, P38936
    Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular
    proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing
    phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in
    the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At
    higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex
    Induction: Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1

         Genatlas biochemistry entry for CDKN1A:
    wild type p53-activated fragment 1,p21,regulator of cell cycle,cyclin dependent kinases 2 and 4 (CDK2/CDK4)
    inhibitor protein,involved in cell cycle exit in megacaryocyte,inhibiting cycle progression by interacting with
    G1 cyclin/CDK complexes and PCNA,this inhibitory activity antagonizing apoptosis being located in cell nucleus
    while,apoptosis activity located in cytoplasm,cleaved by caspase 3 in the earlier stage of apoptosis,mutated in
    breast carcinoma,deleted in some papillary thyroid carcinoma,hybridizing with WI-7311,WI-10190,inhibited by AMPHL
    in early stage of muscle differentiation program,controlling differentiation of skeletal muscle and alveoli in
    the lung in parallel with P21 and myogenin,also functioning as a suppressor of malignant skin tumor formation and
    as a determinant of keratinocyte stem-cell potential

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity TAS7958916
    GO:0005515protein binding IPI15232106
    GO:0019912cyclin-dependent protein kinase activating kinase activity IDA9106657
    GO:0030332cyclin binding IEA--
    GO:0032403protein complex binding IEA--
         
    CDKN1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDKN1A:
     Decreased nuclei size in G2M 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdkn1a) (see all 26):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    CDKN1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDKN1A: Cdkn1atm1Tyj Cdkn1atm1Led

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKN1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDKN1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKN1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKN1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDKN1A:
    hsa-mir-519c-3p (MIRT006641), hsa-mir-423-3p (MIRT000589), hsa-mir-520b (MIRT000583), hsa-mir-520h (MIRT000582), hsa-mir-182-5p (MIRT000576), hsa-mir-299-5p (MIRT000593), hsa-mir-132-3p (MIRT000601), hsa-mir-302a-3p (MIRT004660), hsa-mir-28-5p (MIRT000595), hsa-mir-519d-3p (MIRT000586), hsa-mir-17-5p (MIRT000600), hsa-mir-519e-3p (MIRT000585), hsa-mir-146a-5p (MIRT004661), hsa-mir-146b-5p (MIRT004662), hsa-mir-335-5p (MIRT017254), hsa-mir-208b-3p (MIRT000598), hsa-mir-1229-3p (MIRT036272), hsa-let-7f-5p (MIRT032095), hsa-mir-106b-5p (MIRT000603), hsa-mir-572 (MIRT000581), hsa-let-7a-5p (MIRT032506), hsa-mir-208a-3p (MIRT000599), hsa-mir-125a-5p (MIRT000602), hsa-mir-345-5p (MIRT000592), hsa-mir-639 (MIRT000580), hsa-mir-519b-3p (MIRT000587), hsa-mir-515-3p (MIRT000588), hsa-mir-372-3p (MIRT000590), hsa-mir-98-5p (MIRT027507), hsa-mir-10b-5p (MIRT006369), hsa-mir-505-5p (MIRT037948), hsa-mir-657 (MIRT000578), hsa-mir-503-5p (MIRT000642), hsa-mir-520a-3p (MIRT000584), hsa-mir-654-3p (MIRT000579), hsa-mir-298 (MIRT000594), hsa-mir-20b-5p (MIRT000596), hsa-mir-1260b (MIRT052713), hsa-mir-106a-5p (MIRT001223), hsa-mir-363-3p (MIRT000591), hsa-mir-145-5p (MIRT000575), hsa-mir-519a-3p (MIRT006234), hsa-mir-942-5p (MIRT000574), hsa-mir-96-5p (MIRT003414), hsa-mir-93-5p (MIRT000577), hsa-mir-20a-5p (MIRT000597)

    Block miRNA regulation of human, mouse, rat CDKN1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKN1A (see all 48):
    hsa-let-7d hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmidCDKN1A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN1A (NM_000389)
    Sino Biological Human cDNA Clone for CDKN1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN1A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDN1A_HUMAN, P38936: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular2
    mitochondrion2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----

    CDKN1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKN1A About   (see all 84)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glioma
    Glioma0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    Prostate cancer0.39
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    3E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CDKN1A
        Apoptosis Signaling Pathways
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDKN1A (see all 16)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Glucocorticoid Receptor Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CDKN1A
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CDKN1A (see all 15)
        Transcription Androgen Receptor nuclear signaling
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction AKT signaling

    Selected BioSystems Pathways for CDKN1A (see all 29)
        Cell cycle
    DNA damage response
    Senescence and Autophagy
    Adipogenesis
    G1 to S cell cycle control


    Selected Reactome Pathways for CDKN1A (see all 11)
        AKT phosphorylates targets in the cytosol
    SCF(Skp2)-mediated degradation of p27/p21
    Transcriptional activation of cell cycle inhibitor p21
    Orc1 removal from chromatin
    Cyclin E associated events during G1/S transition

    1 PharmGKB Pathway for CDKN1A
        Celecoxib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CDKN1A) (see all 21):
        ErbB signaling pathway
    HIF-1 signaling pathway
    FoxO signaling pathway
    Cell cycle
    p53 signaling pathway


    CDKN1A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN1A (see all 32): 
              Lung Cancer in human mouse rat
              Prostate Cancer in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDKN1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDKN1A (P389361, 2, 3 ENSP000002447414) via UniProtKB, MINT, STRING, and/or I2D (see all 367)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-375077,EBI-295644 MINT-3370718 MINT-50418 I2D: score=8 STRING: ENSP00000257904
    SKP1P632081, 2, 3, ENSP000002314874EBI-375077,EBI-307486 MINT-1774098 MINT-1774140 I2D: score=1 STRING: ENSP00000231487
    CCND2P302791, 2, 3, ENSP000002612544EBI-375077,EBI-748789 MINT-2635378 I2D: score=5 STRING: ENSP00000261254
    DDAH2O958652, 3MINT-8251783 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8251783 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS8242751
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle IMP17553787
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation IDA9106657

    CDKN1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKN1A (CDN1A)

    Selected Novoseek inferred chemical compound relationships for CDKN1A gene (see all 147)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    depsipeptide 67.4 46 15014036 (7), 12767524 (5), 12773551 (4), 15024582 (3) (see all 14)
    suberoylanilide hydroxamic acid 62.5 10 17634558 (4), 16877001 (1), 18541724 (1), 19157955 (1) (see all 7)
    pic 1 62 14 7493356 (3), 7676688 (1), 9363658 (1), 11299759 (1)
    butyrate 60.5 82 9695075 (5), 13678314 (5), 9663465 (4), 9618491 (3) (see all 33)
    pxd-101 57.8 1 19172229 (1)
    7-hydroxystaurosporine 56.2 4 19259937 (1), 11092986 (1)
    optimax 54.3 1 15385108 (1)
    bortezomib 54 18 19661301 (3), 19020781 (2), 15609327 (1), 15464472 (1) (see all 9)
    noxa 53.2 19 18340116 (2), 16363065 (2), 14749479 (1), 17043642 (1) (see all 11)
    doxorubicin 51.8 101 15601469 (6), 17974990 (6), 15823547 (4), 12151346 (4) (see all 38)



    CDKN1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDKN1A gene (4 alternative transcripts): 
    NM_000389.4  NM_001220777.1  NM_001220778.1  NM_078467.2  

    Unigene Cluster for CDKN1A:

    Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
    Hs.370771  [show with all ESTs]
    Unigene Representative Sequence: NM_001220778
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459970 ENST00000244741(uc021yzb.1 uc021yzc.1 uc011dtq.2 uc003omm.4)
    ENST00000373711 ENST00000478800 ENST00000462537 ENST00000448526 ENST00000405375(uc003omn.3)

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    hsa-let-7d hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-208a
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      QuantiFast Probe-based Assays in human, mouse, rat CDKN1A

    Additional mRNA sequence: 

    AB209881.1 AB451290.1 AB451422.1 AK298901.1 BC000275.1 BC000312.2 BC001935.1 BC013967.2 
    BT006719.1 CR536533.1 L25610.1 L26165.1 L47232.1 L47233.1 S67388.1 U03106.1 
    U09579.1 

    19 DOTS entries:

    DT.95096850  DT.75163257  DT.100683496  DT.100683499  DT.95096855  DT.100830436  DT.100038552  DT.121328015 
    DT.100672380  DT.102834224  DT.121328011  DT.95096852  DT.95096862  DT.95321978  DT.100691442  DT.121327971 
    DT.95112086  DT.97765072  DT.100683502 

    Selected AceView cDNA sequences (see all 966):

    CA421306 AI813378 BM554128 CF131951 AL701944 CF131859 CN480778 AW338097 
    BQ940274 CF132236 AI147453 BC000312 CR590203 CF132699 CF132036 BQ933082 
    BM503398 CF131578 BE263622 BM559647 BI335910 CR612385 CD742552 AI073360 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDKN1A (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                    -     -     -     -     -     -     -     -     -                                             
    SP2:                                            -     -     -     -     -           -                                 
    SP3:                                            -     -     -     -     -                                             
    SP4:                                                        -     -     -                                             
    SP5:                                                              -     -                                             


    ECgene alternative splicing isoforms for CDKN1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKN1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCCTGGTT
    CDKN1A Expression
    About this image


    CDKN1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Dental Placode Cells Dental Placode
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    CDKN1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKN1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370771

    UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
    Tissue specificity: Expressed in all adult tissues, with 5-fold lower levels observed in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDKN1A (see all 32): 
              Lung Cancer in human mouse rat
              Prostate Cancer in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN1A gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkn1a1 , 5 cyclin-dependent kinase inhibitor 1A (P21)1, 5 76.52(n)1
    79.25(a)1
      17 (15.12 cM)5
    125751  NM_007669.41  NP_031695.11 
     290909795 
    chicken
    (Gallus gallus)
    Aves CIP16
    Gallus gallus cdk inhibitor CIP1 (p21) (CIP1), mRN...
    39(a)
    1 ↔ 1
    26(1543127-1545030)
    lizard
    (Anolis carolinensis)
    Reptilia CDKN1A6
    cyclin-dependent kinase inhibitor 1A (p21, Cip1)
    40(a)
    1 ↔ 1
    4(123542677-123558278)
    zebrafish
    (Danio rerio)
    Actinopterygii cdkn1a6
    cyclin-dependent kinase inhibitor 1A
    30(a)
    1 ↔ 1
    22(577559-582981) ENSDARG00000076554


    ENSEMBL Gene Tree for CDKN1A (if available)
    TreeFam Gene Tree for CDKN1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKN1A gene
    CDKN1C2  CDKN1B2  
    3 SIMAP similar genes for CDKN1A using alignment to 2 protein entries:     CDN1A_HUMAN (see all proteins):
    CDKN1C    p27 kip1    CDKN1B

    CDKN1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKN1A (see all 376)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18012701,2,,4
    C,F,A,Hnon-pathogenic136563234(+) CTGAGC/ACGCGA 8 /R /S mis132Minor allele frequency- A:0.17NS MN NA EA NEA_ME WA CSA EU 9329
    rs47140031,2
    C,F,A,H--36553522(+) TCTGAC/TGAGCC 1 -- us2k19Minor allele frequency- T:0.32NA WA CSA EA 370
    rs747534421,2
    C,F--36553566(+) CCCCAA/GTGCAG 2 -- us2k12Minor allele frequency- G:0.02CSA WA 120
    rs1137785471,2
    F--36553623(+) GTGGTG/ATCTCC 2 -- us2k12Minor allele frequency- A:0.33CSA 6
    rs109476221,2
    C,F,A,H--36553664(+) AGGGCC/TGACAT 2 -- us2k19Minor allele frequency- T:0.32NA WA CSA EA 371
    rs589165111,2
    C--36553667(+) GCCGA-/CATGGG 2 -- us2k10--------
    rs1153683501,2
    F--36553750(+) GGCCCC/GTCTGT 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1866326161,2
    --36553766(+) CATGCC/TCAGCG 2 -- us2k10--------
    rs1428350921,2
    C--36553770(+) CCCAGC/TGGCAA 2 -- us2k10--------
    rs1142687781,2
    F--36553808(+) AGCCAG/TGAACA 2 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for CDKN1A (36644237 - 36655116 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDKN1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885807CNV Loss21882294

    Human Gene Mutation Database (HGMD): CDKN1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDKN1A
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKN1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116899    OMIM disorders: --

    Selected diseases for CDKN1A (see all 229):    
    About MalaCards
    bladder transitional cell carcinoma    thoracic cancer    invasive bladder transitional cell carcinoma    tongue cancer
    gastrointestinal lymphoma    transitional cell carcinoma    extramedullary plasmacytoma    papilloma
    wermer syndrome    lung adenoma    maxillary sinus squamous cell carcinoma    superficial spreading melanoma
    esophagus adenocarcinoma    bladder transitional cell papilloma    hypervitaminosis a    nodular malignant melanoma
    verrucous carcinoma    keratoacanthoma    adenocarcinoma in situ    cervical adenocarcinoma

    10 diseases from the University of Copenhagen DISEASES database for CDKN1A:
    Retinoblastoma     Carcinoma     Breast cancer     Prostate cancer
    Colorectal cancer     Hepatocellular carcinoma     Leukemia     Lung cancer
    Melanoma     Malignant glioma

    CDKN1A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CDKN1A gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 81.9 127 11306502 (3), 15752352 (2), 9650754 (2), 10769022 (2) (see all 99)
    tumors 78.9 1092 12792888 (6), 10931462 (6), 12872447 (6), 15966178 (6) (see all 99)
    cancer 73.9 261 9030251 (4), 1959989 (3), 7812982 (3), 9000576 (2) (see all 99)
    colon cancer 67.9 67 19572978 (3), 19723919 (3), 19150257 (2), 11212250 (2) (see all 49)
    carcinoma squamous cell 62.4 111 10445528 (6), 17203174 (4), 9440786 (3), 11277421 (2) (see all 76)
    breast cancer 62.2 175 11872638 (4), 20086099 (4), 12142081 (3), 17941827 (3) (see all 99)
    carcinoma 59.9 177 9607584 (6), 8883416 (5), 9236898 (4), 17384651 (3) (see all 99)
    colon carcinoma 58.9 46 10782880 (3), 15601469 (2), 9618491 (2), 15165036 (2) (see all 31)
    prostate cancer 58.6 83 12151346 (6), 16281084 (3), 14743466 (3), 15077174 (3) (see all 53)
    ataxia telangiectasia 56.6 13 12576328 (1), 19259937 (1), 12174591 (1), 18386191 (1) (see all 9)

    Genetic Association Database (GAD): CDKN1A
    Human Genome Epidemiology (HuGE) Navigator: CDKN1A (105 documents)
    Tumor Gene Database (TGDB): CDKN1A

    Export disorders for CDKN1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKN1A gene, integrated from 10 sources (see all 3579):
    (articles sorted by number of sources associating them with CDKN1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. (PubMed id 7753561)1, 2, 9 Jiang H.... Fisher P.B. (Oncogene 1995)
    2. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. (PubMed id 19536131)1, 2, 9 Lee E.-W.... Song J. (EMBO J. 2009)
    3. Association of polymorphisms in APOE, p53, and p21 with primary open-angle glaucoma in Turkish patients. (PubMed id 19578553)1, 4, 9 Saglar E....Ogus A. (Mol. Vis. 2009)
    4. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. (PubMed id 12431783)1, 2, 9 Wang Z....Magnuson N.S. (Biochim. Biophys. Acta 2002)
    5. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study. (PubMed id 19910837)1, 4, 9 Chen J....Frazier M.L. (Pancreas 2010)
    6. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. (PubMed id 18694622)1, 4, 9 Chen J....Frazier M.L. (Cancer Lett. 2008)
    7. [Association of polymorphisms of p21cip1 and p27kip1 genes with susceptibilities of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (PubMed id 16480585)1, 4, 9 Guo W....Zhang J.H. (Ai Zheng 2006)
    8. The nonsynonymous single-nucleotide polymorphisms in codon 31 of p21 gene and the susceptibility to cervical cancer in Chinese women. (PubMed id 19820361)1, 4, 9 Tian Q....Xie X. (Int. J. Gynecol. Cancer 2009)
    9. Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women. (PubMed id 11179504)1, 4, 9 Harima Y....Ohnishi T. (Int. J. Mol. Med. 2001)
    10. P53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in Korean women. (PubMed id 20524403)1, 4, 9 Roh J.W....Kang S.B. (Oncol. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1026 HGNC: 1784 AceView: CDKN1A Ensembl:ENSG00000124762 euGenes: HUgn1026
    ECgene: CDKN1A Kegg: 1026 H-InvDB: CDKN1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDKN1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN1A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDKN1A gene:
    Search GeneIP for patents involving CDKN1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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