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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDKN1A Gene

protein-coding   GIFtS: 71
GCID: GC06P036649

cyclin-dependent kinase inhibitor 1A (p21, Cip1)


(Previous symbol: CDKN1)
 Explore 260 diseases affiliated with
CDKN1A via
MalaCards
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 Human Malady Compendium 
Biological research products
for CDKN1A    

Aliases
for CDKN1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1)1 2     P21Cip1/Waf11
CDKN11 2 3 5     CDK-Interaction Protein 12
CIP11 2 3 5     Cyclin-Dependent Kinase Inhibitor 12
WAF11 2 3 5     DNA Synthesis Inhibitor2
CAP201 2 3     Melanoma Differentiation Associated Protein 62
SDI11 2 3     Wild-Type P53-Activated Fragment 12
P211 2     MDA63
P21CIP11     PIC13
MDA-62 3     Melanoma Differentiation-Associated Protein 63
CDK-Interacting Protein 12 3     P211 2

External Ids:    HGNC: 17841   Entrez Gene: 10262   Ensembl: ENSG000001247627   OMIM: 1168995   UniProtKB: P389363   

Export aliases for CDKN1A gene to outside databases

Previous GC identifers: GC06P036648 GC06P036693 GC06P036754 GC06P036645 GC06P036364


Summaries
for CDKN1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDKN1A:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of
cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of
this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the
p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with
proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase
DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases,
which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following
caspase activation. Multiple alternatively spliced variants have been found for this gene. (provided by RefSeq, Nov
2010)

UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular
proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing
phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the
nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher
stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex

Gene Wiki entry for CDKN1A (P21)


Genomic Views
for CDKN1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKN1A gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CDKN1A promoter sequence
   Search SABiosciences Chromatin IP Primers for CDKN1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKN1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.1

CDKN1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036649:  view genomic region     (about GC identifiers)

Start:
 36,644,305 bp from pter      End:
 36,655,116 bp from pter
Size:
 10,812 bases      Orientation:
 plus strand

Proteins
for CDKN1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936 (See protein sequence)
Recommended Name: Cyclin-dependent kinase inhibitor 1  
Size: 164 amino acids; 18119 Da
Subunit: Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1
facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts with
PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal
domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and
promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E inactivation at the
G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Interacts with
PIM1
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAB59559.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAB59560.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for CDKN1A:
1AXC (3D)        2ZVV (3D)        2ZVW (3D)    
Secondary accessions: Q14010 Q9BUT4

Explore the universe of human proteins at neXtProt for CDKN1A: NX_P38936

Post-translational modifications:

  • Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta
    • enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and
    inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm
    and enhanced CDKN1A protein stability1
  • Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the
    • DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV
    irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is
    PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP
    box, recruit the DCX(DTL) complex, leading to its degradation1
  • Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by
    • HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P38936

    • CDKN1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_000380.1  NP_001207706.1  NP_001207707.1  NP_510867.1  

    ENSEMBL proteins: 
     ENSP00000244741   ENSP00000362815   ENSP00000409259   ENSP00000384849  
    Reactome Protein details: P38936
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CDKN1A
    OriGene Purified Protein: CDKN1A
    OriGene Protein Over-expression Lysate: CDKN1A
    OriGene Custom Protein Services for CDKN1A 
    GenScript Custom Purified and Recombinant Proteins Services for CDKN1A
    Novus Biologicals CDKN1A Proteins
    Novus Biologicals CDKN1A Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CDKN1A
    Uscn Proteins for CDKN1A

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0005634nucleus IDA11343236
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    CDKN1A for ontologies           About GeneDecksing



    CDKN1A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDKN1A
    R&D Systems Antibodies for CDKN1A (p21/CIP1/CDKN1A)
    Cell Signaling Technology (CST) Antibodies for CDKN1A  (p21Cip1)
    OriGene Antibodies (see all 3): CDKN1A
    OriGene Custom Antibody Services for CDKN1A 
    GenScript Custom Superior Antibodies Services for CDKN1A
    Novus Biologicals CDKN1A Antibodies
    Abcam antibodies for CDKN1A 
    Uscn Antibodies for CDKN1A
    ThermoFisher Antibody for CDKN1A

    Assay Products for CDKN1A: 
    EMD Millipore Kits and Assays for the Analysis of CDKN1A
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for CDKN1A (p21/CIP1/CDKN1A)         (see all)
    GenScript CDKN1A-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for CDKN1A (p21Cip1)
    Enzo Life Sciences assays for CDKN1A
    Uscn ELISAs and CLIAs for CDKN1A

    Protein Domains /
    Families
    for CDKN1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDKN1A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003175 CDI

    Graphical View of Domain Structure for InterPro Entry P38936

    ProtoNet protein and cluster: P38936

    1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor

    UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
    Domain: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while
    the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its
    ubiquitination
    Domain: The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex
    Similarity: Belongs to the CDI family


    Function
    for CDKN1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
    Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular
    proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing
    phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the
    nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher
    stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex
    Induction: Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1

         Genatlas biochemistry entry for CDKN1A:
    wild type p53-activated fragment 1,p21,regulator of cell cycle,cyclin dependent kinases 2 and 4 (CDK2/CDK4) inhibitor
    protein,involved in cell cycle exit in megacaryocyte,inhibiting cycle progression by interacting with G1 cyclin/CDK
    complexes and PCNA,this inhibitory activity antagonizing apoptosis being located in cell nucleus while,apoptosis
    activity located in cytoplasm,cleaved by caspase 3 in the earlier stage of apoptosis,mutated in breast
    carcinoma,deleted in some papillary thyroid carcinoma,hybridizing with WI-7311,WI-10190,inhibited by AMPHL in early
    stage of muscle differentiation program,controlling differentiation of skeletal muscle and alveoli in the lung in
    parallel with P21 and myogenin,also functioning as a suppressor of malignant skin tumor formation and as a determinant
    of keratinocyte stem-cell potential

    miRNA
    Products:            		miRTarBase miRNAs that target CDKN1A:
    hsa-mir-423-3p (MIRT000589), hsa-mir-520b (MIRT000583), hsa-mir-520h (MIRT000582), hsa-mir-182 (MIRT000576), hsa-mir-299-5p (MIRT000593), hsa-mir-132 (MIRT000601), hsa-mir-302a (MIRT004660), hsa-mir-28-5p (MIRT000595), hsa-mir-519d (MIRT000586), hsa-mir-17 (MIRT000600), hsa-mir-519e (MIRT000585), hsa-mir-146a (MIRT004661), hsa-mir-146b-5p (MIRT004662), hsa-mir-208b (MIRT000598), hsa-mir-106b (MIRT000603), hsa-mir-572 (MIRT000581), hsa-mir-208a (MIRT000599), hsa-mir-125a-5p (MIRT000602), hsa-mir-345 (MIRT000592), hsa-mir-639 (MIRT000580), hsa-mir-519b-3p (MIRT000587), hsa-mir-515-3p (MIRT000588), hsa-mir-372 (MIRT000590), hsa-mir-657 (MIRT000578), hsa-mir-503 (MIRT000642), hsa-mir-520a-3p (MIRT000584), hsa-mir-654-3p (MIRT000579), hsa-mir-298 (MIRT000594), hsa-mir-20b (MIRT000596), hsa-mir-106a (MIRT001223), hsa-mir-363 (MIRT000591), hsa-mir-145 (MIRT000575), hsa-mir-942 (MIRT000574), hsa-mir-96 (MIRT003414), hsa-mir-93 (MIRT000577), hsa-mir-20a (MIRT000597)

    OriGene 3'-UTR Clone (see all 2): CDKN1A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKN1A
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN1A (see all 48):
    hsa-let-7d hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmid: CDKN1A 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of CDKN1A Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKN1A (see all 7)
    OriGene shRNA RFP: CDKN1A
    OriGene siRNA: CDKN1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKN1A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDKN1A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN1A (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKN1A (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CDKN1A (NM_000389)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKN1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN1A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDKN1A
    Search LifeMap BioReagents cell lines for CDKN1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN1A

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein kinase inhibitor activity IEA--
    GO:0005515protein binding IPI--
    GO:0019912cyclin-dependent protein kinase activating kinase activity IDA9106657
    GO:0030332cyclin binding IEA--
    GO:0032403protein complex binding IEA--


    CDKN1A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CDKN1A:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-outs for CDKN1A: Cdkn1atm1Tyj Cdkn1atm1Led
         15/25 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cdkn1a) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    CDKN1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDKN1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/69 super-pathways (see all 69) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/15 pathways (see all 15)
    		p53-Dependent G1/S DNA damage checkpoint0.83
    		Removal of licensing factors from origins0.68
    		p53-Dependent G1 DNA Damage Response0.83
    		Cyclin E associated events during G1/S transition 0.67
    		G1/S DNA Damage Checkpoints0.79
    		Cyclin A:Cdk2-associated events at S phase entry0.66
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		Synthesis of DNA0.51
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    4Transcriptional activation of cell cycle inhibitor p21
    		Transcriptional activation of cell cycle inhibitor p21 1.00
    		Transcriptional activation of p53 responsive genes 1.00
    		Transcriptional activation of p21 by p53 after DNA damage1.00
    		AKT phosphorylates targets in the cytosol0.08
    5Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		Estrogen-mediated S-Phase Entry0.55
    		G2-M Phase Transition0.59
    		p53 Signaling0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 EMD Millipore Pathways for CDKN1A (see all 17)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Androgen Receptor nuclear signaling
    Development TGF-beta receptor signaling
    Development Role of Activin A in cell differentiation and proliferation
    Transcription P53 signaling pathway

    1 R&D Systems Pathway for CDKN1A
        Apoptosis Signaling Pathways

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDKN1A (see all 16)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Glucocorticoid Receptor Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CDKN1A
        Cell Cycle / Checkpoint Control

    5/15 GeneGo (Thomson Reuters) Pathways for CDKN1A (see all 15)
        Transcription Androgen Receptor nuclear signaling
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction AKT signaling

    5/28 BioSystems Pathways for CDKN1A (see all 28) 
        DNA damage response
    Cell cycle
    G1 to S cell cycle control
    miRNAs involved in DDR
    Senescence and Autophagy

    5/24        Reactome Pathways for CDKN1A (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Mitotic G1-G1/S phases
    Transcriptional activation of cell cycle inhibitor p21
    DNA Replication
    Removal of licensing factors from origins

    1 PharmGKB Pathway for CDKN1A
        Celecoxib Pathway, Pharmacodynamics

    5/10         Kegg Pathways  (Kegg details for CDKN1A) (see all 10):
        ErbB signaling pathway
    Cell cycle
    p53 signaling pathway
    Hepatitis C
    Pathways in cancer


    CDKN1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/335 Interacting proteins for CDKN1A (P389361, 2, 3 ENSP000002447414) via UniProtKB, MINT, STRING, and/or I2D (see all 335)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-375077,EBI-295644 MINT-3370718 MINT-50418 I2D: score=8 STRING: ENSP00000257904
    TP53P046372, 3, ENSP000002693054MINT-1891378 MINT-8252340 I2D: score=3 STRING: ENSP00000269305
    SKP1P632082, 3, ENSP000002314874MINT-1774098 MINT-1774140 I2D: score=1 STRING: ENSP00000231487
    PCNAP120041, 3, ENSP000003684384EBI-375077,EBI-358311 I2D: score=7 STRING: ENSP00000368438
    CCNB1P146352, 3, ENSP000002564424MINT-50660 I2D: score=6 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000079regulation of cyclin-dependent protein kinase activity TAS8242751
    GO:0000080G1 phase of mitotic cell cycle TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--


    CDKN1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDKN1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDKN1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDKN1A
    10/147 Novoseek chemical compound relationships for CDKN1A gene (see all 147)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    depsipeptide 67.4 46 15014036 (7), 12767524 (5), 12773551 (4), 15024582 (3) (see all 14)
    suberoylanilide hydroxamic acid 62.5 10 17634558 (4), 16877001 (1), 18541724 (1), 19157955 (1) (see all 7)
    pic 1 62 14 7493356 (3), 7676688 (1), 9363658 (1), 11299759 (1)
    butyrate 60.5 82 9695075 (5), 13678314 (5), 9663465 (4), 9618491 (3) (see all 33)
    pxd-101 57.8 1 19172229 (1)
    7-hydroxystaurosporine 56.2 4 19259937 (1), 11092986 (1)
    optimax 54.3 1 15385108 (1)
    bortezomib 54 18 19661301 (3), 19020781 (2), 15609327 (1), 15464472 (1) (see all 9)
    noxa 53.2 19 18340116 (2), 16363065 (2), 14749479 (1), 17043642 (1) (see all 11)
    doxorubicin 51.8 101 15601469 (6), 17974990 (6), 15823547 (4), 12151346 (4) (see all 38)

    Search CenterWatch for drugs/clinical trials and news about CDKN1A / CDN1A 

    Transcripts
    for CDKN1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDKN1A gene (4 alternative transcripts): 
    NM_000389.4  NM_001220777.1  NM_001220778.1  NM_078467.2  

    Unigene Cluster for CDKN1A:

    Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
    Hs.370771  [show with all ESTs]
    Unigene Representative Sequence: NM_001220778
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459970 ENST00000244741(uc021yzb.1 uc021yzc.1 uc011dtq.2 uc003omm.4)
    ENST00000373711 ENST00000478800 ENST00000462537 ENST00000448526 ENST00000405375(uc003omn.3)


    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKN1A (see all 48):
    hsa-let-7d hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmid: CDKN1A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKN1A (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AB209881.1 AB451290.1 AB451422.1 AK298901.1 BC000275.1 BC000312.2 BC001935.1 BC013967.2 
    BT006719.1 CR536533.1 L25610.1 L26165.1 L47232.1 L47233.1 S67388.1 U03106.1 
    U09579.1 

    19 DOTS entries:

    DT.95096850  DT.75163257  DT.100683496  DT.100683499  DT.95096855  DT.100830436  DT.100038552  DT.121328015 
    DT.100672380  DT.121328011  DT.95096852  DT.95096862  DT.95321978  DT.100691442  DT.121327971  DT.95112086 
    DT.97765072  DT.100683502  DT.102834224 

    24/966 AceView cDNA sequences (see all 966):

    BX402366 CF127818 CF132157 CF132002 AA534613 BE795904 CF132253 BQ003565 
    CA450180 CF132228 AW246700 CF131859 BG236329 BM554128 BM457854 BQ017971 
    BU539527 AI073360 BU176479 BI870130 AA962447 AL542973 CF132235 AA310434 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN1A (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                    -     -     -     -     -     -     -     -     -                                             
    SP2:                                            -     -     -     -     -           -                                 
    SP3:                                            -     -     -     -     -                                             
    SP4:                                                        -     -     -                                             
    SP5:                                                              -     -                                             


    ECgene alternative splicing isoforms for CDKN1A

    Expression
    for CDKN1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDKN1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTCCTGGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDKN1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/31 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 31) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneCervical VertebraeChondrocytesBone, Cartilage
    BoneLumbar VertebraeChondrocytesBone, Cartilage
    BoneSacral VertebraeChondrocytesBone, Cartilage
    BoneStylopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneThoracic RibChondrocytesBone, Cartilage
    BoneThoracic VertebraeChondrocytesBone, Cartilage
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    LimbForelimb Dorsal MusclesMyoblastsSkeletal Muscle
    LimbForelimb Ventral MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See CDKN1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDKN1A

    SOURCE GeneReport for Unigene cluster: Hs.370771

    UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
    Tissue specificity: Expressed in all adult tissues, with 5-fold lower levels observed in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN1A (see all 32): 
              Lung Cancer in human mouse rat
              Prostate Cancer in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat

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    Orthologs
    for CDKN1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDKN1A gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDKN1A6
    		 Uncharacterized protein
    		 42(a)
    		 1 ↔ 1
    		 1(74373197-74373976)
    lizard
    (Anolis carolinensis)    		 Reptilia CDKN1A6
    		 --
    		 37(a)
    		 1 ↔ 1
    		 4(123553048-123554163)
    zebrafish
    (Danio rerio)    		 Actinopterygii cdkn1a6
    		 cyclin-dependent kinase inhibitor 1A
    		 32(a)
    		 1 ↔ 1
    		 22(577559-582981)


    ENSEMBL Gene Tree for CDKN1A (if available)
    TreeFam Gene Tree for CDKN1A (if available) 

    Paralogs
    for CDKN1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDKN1A gene
    CDKN1C2  CDKN1B2  
    3 SIMAP similar genes for CDKN1A using alignment to 3 protein entries:     CDN1A_HUMAN (see all proteins):
    CDKN1C    p27 kip1    CDKN1B

    CDKN1A for paralogs           About GeneDecksing



    Genomic Variants
    for CDKN1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in CDKN1A are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs18012701,2
    		C,F,A,H,non-pathogenic36651971(+) CTGAGC/ACGCGA 8 /R /S mis132Minor allele frequency- A:0.17NS MN NA EA WA CSA EU 9329
    rs47140031,2
    		C,F,A,H,--36642260(+) TCTGAC/TGAGCC 1 -- us2k19Minor allele frequency- T:0.32NA WA CSA EA 370
    rs747534421,2
    		--36642304(+) CCCCAA/GTGCAG 2 -- us2k12Minor allele frequency- G:0.02CSA WA 120
    rs1137785471,2
    		F,--36642361(+) GTGGTG/ATCTCC 2 -- us2k12Minor allele frequency- A:0.33CSA 6
    rs109476221,2
    		C,F,A,H,--36642402(+) AGGGCC/TGACAT 2 -- us2k19Minor allele frequency- T:0.32NA WA CSA EA 371
    rs589165111,2
    		C,--36642405(+) GCCGA-/CATGGG 2 -- us2k10--------
    rs1153683501,2
    		F,--36642488(+) GGCCCC/GTCTGT 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1866326161,2
    		--36642504(+) CATGCC/TCAGCG 2 -- us2k10--------
    rs1428350921,2
    		--36642508(+) CCCAGC/TGGCAA 2 -- us2k10--------
    rs1142687781,2
    		--36642546(+) AGCCAG/TGAACA 2 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for CDKN1A (36644305 - 36655116 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDKN1A: --
    Human Gene Mutation Database (HGMD): CDKN1A

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    Disorders / Diseases
    for CDKN1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDKN1A for disorders           About GeneDecksing

    OMIM gene information: 116899    OMIM disorders: --

    20/260 diseases for CDKN1A (see all 260):    About MalaCards
    li-fraumeni syndrome    open-angle glaucoma    squamous cell carcinoma    superficial spreading melanoma
    diffuse large b-cell lymphoma    human t-cell leukemia virus type 1    primary open angle glaucoma    maxillary sinus squamous cell carcinoma
    invasive bladder transitional cell carcinoma    gliomatosis cerebri    melanoma    bladder transitional cell carcinoma
    recurrent respiratory papillomatosis    dna topoisomerase ii    bladder transitional cell papilloma    extramedullary plasmacytoma
    non-small cell lung carcinoma    actinic cheilitis    nijmegen breakage syndrome    adenomatous polyposis coli

    10 diseases from the University of Copenhagen DISEASES database for CDKN1A:
    Retinoblastoma     Carcinoma     Breast cancer     Prostate cancer
    Colorectal cancer     Hepatocellular carcinoma     Leukemia     Lung cancer
    Malignant glioma     Melanoma

    10/91 Novoseek disease relationships for CDKN1A gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 81.9 127 11306502 (3), 15752352 (2), 9650754 (2), 10769022 (2) (see all 99)
    tumors 78.9 1092 12792888 (6), 10931462 (6), 12872447 (6), 15966178 (6) (see all 99)
    cancer 73.9 261 9030251 (4), 1959989 (3), 7812982 (3), 9000576 (2) (see all 99)
    colon cancer 67.9 67 19572978 (3), 19723919 (3), 19150257 (2), 11212250 (2) (see all 49)
    carcinoma squamous cell 62.4 111 10445528 (6), 17203174 (4), 9440786 (3), 11277421 (2) (see all 76)
    breast cancer 62.2 175 11872638 (4), 20086099 (4), 12142081 (3), 17941827 (3) (see all 99)
    carcinoma 59.9 177 9607584 (6), 8883416 (5), 9236898 (4), 17384651 (3) (see all 99)
    colon carcinoma 58.9 46 10782880 (3), 15601469 (2), 9618491 (2), 15165036 (2) (see all 31)
    prostate cancer 58.6 83 12151346 (6), 16281084 (3), 14743466 (3), 15077174 (3) (see all 53)
    ataxia telangiectasia 56.6 13 12576328 (1), 19259937 (1), 12174591 (1), 18386191 (1) (see all 9)

    Genetic Association Database (GAD): CDKN1A
    Human Genome Epidemiology (HuGE) Navigator: CDKN1A (105 documents)
    Tumor Gene Database (TGDB): CDKN1A

    Export disorders for CDKN1A gene to outside databases

    Publications
    for CDKN1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDKN1A gene, integrated from 9 sources (see all 3465):
    (articles sorted by number of sources associating them with CDKN1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. (PubMed id 7753561)1, 2, 9 Jiang H.... Fisher P.B. (1995)
    2. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. (PubMed id 19536131)1, 2, 9 Lee E.-W.... Song J. (2009)
    3. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. (PubMed id 12431783)1, 2, 9 Wang Z....Magnuson N.S. (2002)
    4. Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women. (PubMed id 11179504)1, 4, 9 Harima Y....Ohnishi T. (2001)
    5. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (PubMed id 18794347)1, 2, 9 Abbas T....Dutta A. (2008)
    6. Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan. (PubMed id 16289646)1, 4, 9 Lai K.C....Tsai F.J. (2005)
    7. Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)1, 4, 9 Soto Martinez J.L....Lopez-Nevot M.A. (2005)
    8. p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer. (PubMed id 15598783)1, 4, 9 Huang S.P....Huang C.H. (2004)
    9. Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. (PubMed id 10753973)1, 2, 9 Scott M.T.... Ball K.L. (2000)
    10. Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck. (PubMed id 15878916)1, 4, 9 Li G....Wei Q. (2005)

    External Searches for CDKN1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDKN1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1026 HGNC: 1784 AceView: CDKN1A Ensembl:ENSG00000124762 euGenes: HUgn1026
    ECgene: CDKN1A Kegg: 1026 H-InvDB: CDKN1A

    Other Databases showing CDKN1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDKN1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDKN1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKN1A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn1a/

    Intellectual Property
    for CDKN1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDKN1A gene:
    Search GeneIP for patents involving CDKN1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     Recombinant Protein for CDKN1A




     CDKN1A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CDKN1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKN1A
     SwitchGear 3'UTR luciferase reporter plasmids for CDKN1A
     SwitchGear Promoter luciferase reporter plasmids for CDKN1A
     ThermoFisher Antibody for CDKN1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKN1A
           
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