V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CDKN1A Gene

protein-coding GIFtS: 69

GC06P036754

cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CDKN1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAP20 ^¹, ², ³
CDKN1 ^², ³, ⁵
CIP1 ^¹, ², ³, ⁵
MDA-6 ^², ³
MDA6 ^³
OTTHUMP00000016298 ^²
P21 ^¹, ²
PIC1 ^³
SDI1 ^¹, ², ³
WAF1 ^¹, ², ³, ⁵
p21 ^³
p21CIP1 ^¹, ²
p21Cip1/Waf1 ^¹, ²

Descriptions
CDK-interacting protein 1 ^³
CDK-interaction protein 1 ^²
DNA synthesis inhibitor ^²
Melanoma differentiation-associated protein 6 ^³
cyclin-dependent kinase inhibitor 1A ^²
cyclin-dependent kinase inhibitor 1A (p21, Cip1) ^²
melanoma differentiation associated protein 6 ^²
wild-type p53-activated fragment 1 ^²

External Ids
HGNC: 1784¹
Entrez Gene: 1026²
UniProtKB: P38936³
Ensembl: ENSG00000124762⁷

Search outside databases for aliases for CDKN1A gene

Previous GC identifers: GC06P036648 GC06P036693

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDKN1A:

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and

inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell

cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor

protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in

response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear

antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA

replication and DNA damage repair. This protein was reported to be specifically cleaved by

CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in

the execution of apoptosis following caspase activation. Two alternatively spliced variants, which

encode an identical protein, have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936

Function: May be the important intermediate by which p53 mediates its role as an inhibitor of

cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase

activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking

cell cycle progression

Gene Wiki entry for CDKN1A (P21)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDKN1A gene

Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.1

CDKN1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P036754: (about GC identifiers)

Start:	36,754,465 bp from pter
End:	36,763,087 bp from pter
Size:	8,623 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936 (See protein sequence)

Recommended Name: Cyclin-dependent kinase inhibitor 1

Size: 164 amino acids; 18119 Da

Subcellular location: Cytoplasm. Nucleus

PDB structures from and Proteopedia :

1AXC (3D)

Secondary accessions: Q14010 Q9BUT4

Post-translational modifications:

Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000380.1 NP_510867.1

ENSEMBL proteins:

ENSP00000362815 ENSP00000384849 ENSP00000244741

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (p21)
	Human Recombinant Proteins from Abnova (CDKN1A)

OriGene Purified Recombinant Human Protein: CDKN1A

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	9190208 9632134 9840943 10323868 11231585 11931757 16782892
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IEA	--

About this table

Antibodies for CDKN1A:

	Invitrogen Antibodies for CDKN1A
	Millipore Mono- and Polyclonal Antibodies for the study of CDKN1A
	Sigma-Aldrich Antibody Arrays and Antibodies for CDKN1A
	R&D Systems Antibodies for CDKN1A (p21/CIP1/CDKN1A)
	Cell Signaling Technology (CST) Antibodies for CDKN1A (p21Cip1)
	Antibodies from Abcam (p21), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDKN1A)
	Novus Biologicals Antibodies for CDKN1A

Assays for CDKN1A:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CDKN1A
	R&D Systems ELISAs for CDKN1A (p21/CIP1/CDKN1A) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for CDKN1A (p21Cip1)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P38936

ProtoNet protein and cluster: P38936

1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor

UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936

Similarity: Belongs to the CDI family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN1A)
		Millipore RNAi Products for the Analysis of CDKN1A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDKN1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_078467

Applied Biosystems Silencer® siRNAs for CDKN1A

Sigma-Aldrich siRNA and siRNA Panels for CDKN1A

Sigma-Aldrich shRNA Panels and shRNA for CDKN1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDKN1A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000389
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000389
untagged cDNA clones in CMV expression vector (see all 2): NM_000389

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_078467

UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936

Function: May be the important intermediate by which p53 mediates its role as an inhibitor of

cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase

activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking

cell cycle progression

Induction: By p53, mezerein (antileukemic compound) and interferon beta

Genatlas biochemistry entry for CDKN1A:

wild type p53-activated fragment 1,p21,regulator of cell cycle,cyclin dependent kinases 2 and 4

(CDK2/CDK4) inhibitor protein,involved in cell cycle exit in megacaryocyte,inhibiting cycle

progression by interacting with G1 cyclin/CDK complexes and PCNA,this inhibitory activity

antagonizing apoptosis being located in cell nucleus while,apoptosis activity located in

cytoplasm,cleaved by caspase 3 in the earlier stage of apoptosis,mutated in breast

carcinoma,deleted in some papillary thyroid carcinoma,hybridizing with WI-7311,WI-10190,inhibited

by AMPHL in early stage of muscle differentiation program,controlling differentiation of skeletal

muscle and alveoli in the lung in parallel with P21 and myogenin,also functioning as a suppressor

of malignant skin tumor formation and as a determinant of keratinocyte stem-cell potential

15/24 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cdkn1a) (see all 24 ):

cellular	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004860	protein kinase inhibitor activity	IEA	--
GO:0004861	cyclin-dependent protein kinase inhibitor activity	TAS	8242751
GO:0008270	zinc ion binding	IEA	--
GO:0030332	cyclin binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for CDKN1A (Your Favorite Gene powered by Ingenuity) (see all 20 )

PI3K/AKT Signaling
VDR/RXR Activation
Bladder Cancer Signaling
Aryl Hydrocarbon Receptor Signaling
ATM Signaling

GeneDecks CDKN1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDKN1A

5/30 Interacting proteins for CDKN1A (P38936^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 30 )
Interactant Interaction Details
GeneCard External ID(s)
CDK2 P24941¹^,² EBI-375077, EBI-375096 MINT-2635357 MINT-73323 MINT-3370697 MINT-50415 EBI-375077, EBI-375096 MINT-2635357 MINT-73323 MINT-3370697 MINT-50415
CDK4 P11802¹^,² EBI-375077, EBI-295644 MINT-3370718 MINT-50418 EBI-375077, EBI-295644 MINT-3370718 MINT-50418
CCNA1 P78396¹^,² EBI-375077, EBI-375065 MINT-50429 EBI-375077, EBI-375065 MINT-50429
CCNB2 O95067¹^,² EBI-375077, EBI-375024 MINT-50432 EBI-375077, EBI-375024 MINT-50432
CCND1 P24385¹^,² EBI-375077, EBI-375001 MINT-50437 EBI-375077, EBI-375001 MINT-50437
About this table
5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 10208428
GO:0000086 G2/M transition of mitotic cell cycle IMP 17553787
GO:0006974 response to DNA damage stimulus IEA --
GO:0007050 cell cycle arrest IEA --
GO:0008285 negative regulation of cell proliferation IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CDKN1A:

Inhibitor

Browse Tocris compounds for CDKN1A
10/45 Novoseek chemical compound relationships for CDKN1A gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pic 1	62.91	14	7493356 (3), 7676688 (1), 9363658 (1), 11299759 (1)
delta 7-pga1	52.52	1	9685248 (1)
eupatilin	49.23	3	19281788 (1), 16393120 (1)
noxa	48.18	17	18340116 (2), 16363065 (2), 14749479 (1), 17951408 (1) (see all 9)
thymidine	45.76	25	18850315 (2), 17192405 (2), 15016620 (2), 17295239 (2) (see all 19)
hrgbeta1	44.11	7	16596219 (3), 9652748 (2)
bromodeoxyuridine	44.06	18	11390614 (2), 11309295 (2), 9736425 (1), 12732930 (1) (see all 11)
mimosine	42.61	11	9401002 (2), 10530763 (2), 12429910 (1), 9488034 (1) (see all 7)
pd 98,059	42.50	24	16322252 (2), 10753954 (2), 17409429 (2), 11447172 (2) (see all 14)
perifosine	41.20	5	14744793 (2), 16760642 (1)

About this table

6 PharmGKB drug compound relationships for CDKN1A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
5-fluorouracil	CO FA	12973835
cyclophosphamide	CO FA	12973835
docetaxel	FA	14578462
gemcitabine	FA	14578462
methotrexate	CO FA	12973835
trastuzumab	FA	14578462

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDKN1A)
		Millipore RNAi Products for the Analysis of CDKN1A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDKN1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_078467

Sigma-Aldrich siRNA and siRNA Panels for CDKN1A

Sigma-Aldrich shRNA Panels and shRNA for CDKN1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000389 NM_078467

REFSEQ mRNAs for CDKN1A gene (2 alternative transcripts):

NM_000389.3 NM_078467.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000389 NM_078467

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000389
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000389
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000389

Additional cDNA sequence:

AB209881.1 AB451290.1 AB451422.1 AK298901.1 AK309512.1 AY008263.1 BC000275.1 BC000312.2

BC001935.1 BC013967.2 BT006719.1 CR536533.1 CR590203.1 CR593617.1 CR606246.1 CR612385.1

CR617250.1 CR621127.1 L25610.1 L26165.1 L47232.1 L47233.1 S67388.1 U03106.1

U09579.1 XM_001718276.1

24 DOTS entries:

DT.95096850 DT.75163257 DT.100683496 DT.100683499 DT.95096855 DT.100830436 DT.100038552 DT.100672380

DT.100690377 DT.121328015 DT.121328011 DT.92458565 DT.95096862 DT.102834224 DT.121327971 DT.95096852

DT.95321978 DT.100691442 DT.121328010 DT.92458582 DT.95096868 DT.95112086 DT.97765072 DT.100683502

24/966 AceView cDNA sequences (see all 966 ):

CF132036 CF131876 CF131916 BM756685 AA376995 AI365137 AW129949 BM503238

AI274741 CF131859 CF132004 CF132002 BM990130 BQ213794 BM460429 CF132291

BF219722 AI862747 CR612385 BE161226 CF132027 CA450180 BM904248 BX378708

highest scoring ESTs for CDKN1A:

U03106 AA029109 AA029196 AA029873 AA065009 AA069286 AA069702 AA069979 AA083831 AA134593

Unigene Cluster for CDKN1A:

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Hs.370771 [show with all ESTs]

Unigene Representative Sequence: NM_078467

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CDKN1A (see all 9 )

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	·	4d	·	4e	·	4f	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	·	10d
SP1:							-		-		-		-		-		-		-		-		-
SP2:															-		-		-		-		-				-
SP3:															-		-		-		-		-
SP4:																			-		-		-
SP5:																					-		-

About this scheme

ECgene alternative splicing isoforms for CDKN1A

3 Ensembl transcripts including schematic representations:

ENST00000373711 ENST00000405375 ENST00000244741

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDKN1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDKN1A

¹ / ² / ³

4 probe-sets matching CDKN1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2031_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U03106	1.00	1.00	1.00	1
202284_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000389	0.60	1.00	0.82	1
202284_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555186_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDKN1A for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.370771
Expression variation in blood from EXPOLDB for CDKN1A
UniProtKB/Swiss-Prot: CDN1A_HUMAN, P38936
Tissue specificity: Expressed in all adult human tissues, with 5-fold lower levels observed in the
brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDKN1A gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDKN1A¹	--	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	83.33(n) 82.93(a)	474890 XM_532125.2 XP_532125.2
chimpanzee (Pan troglodytes)	CDKN1A¹	--	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	99.8(n) 100(a)	747442 XM_001157015.1 XP_001157015.1
cow (Bos taurus)	CDKN1A¹	--	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	82.4(n) 81.99(a)	513497 XM_591188.3 XP_591188.2
rat (Rattus norvegicus)	Cdkn1a¹	--	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	76.54(n) 76.54(a)	114851 NM_080782.3 NP_542960.1
mouse (Mus musculus)	Cdkn1a^{1, 5}	17 (15.23 cM)⁵	cyclin-dependent kinase inhibitor 1A (P21)^{1, 5}	76.52(n)¹ 79.25(a)¹	12575¹ NM_007669.3¹ NP_031695.1¹ AB017817⁵ AB017818⁵ (see all 20)

About this table Species with no ortholog for CDKN1A

ENSEMBL Gene Tree for CDKN1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDKN1A gene

CDKN1C² CDKN1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/34 NCBI SNPs in CDKN1A are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 76)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1801270^1,2	A,C,F,H	36759949(+)	`CTGAGC/ACGCGA`	2	R/S	mis¹		14	NS EU EA WA MN CSAM NA	1318
	rs876581^1,2	A,C,F,H	36763423(-)	`TGTCAG/ATCTTT`	2	--	ng3¹		18	EU EA WA NS NA	1818
	rs4986866^1,2	C,F,H	36759867(+)	`AGAACC/TGGCTG`	2	P/L	mis¹		10	MN CSAM EA EU WA NA	888
	rs1059234^1,2	C,F,H	36761575(+)	`GCCTGC/TAGTCC`	2	--	ut3¹		16	NA EA NS MN CSAM EU WA	1496
	rs4986867^1,2	C,F,H	36760045(+)	`GACTTC/AGCCTG`	2	L/F	mis¹		10	MN CSAM EA EU WA	1006
	rs3176358^1,2	F,H	36761940(+)	`CCATCG/ACTGTC`	2	--	ut3¹ ese³		5	NS EU EA WA	600
	rs3176359^1,2	C,F	36762720(+)	`GCAGCG/AGAACA`	2	--	ut3¹ ese³		5	NS EA NA	1804
	rs12721594^1,2	H	36759999(+)	`TGAGCG/AATGGA`	2	Q/R	mis¹		4	EU EA WA	420
--	rs3176357^1,2	F	36761593(+)	`GCGAGG/CGCCTC`	2	--	ut3¹ ese³		1	NS	178
--	rs4986868^1,2	C,F	36759868(+)	`GAACYG/AGCTGG`	2	P/P	syn¹		8	MN CSAM EA NA	550

About this table

HapMap Linkage Disequilibrium images for CDKN1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116899

10/91 Novoseek disease relationships for CDKN1A gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	82.15	121	11306502 (3), 15752352 (2), 9650754 (2), 10769022 (2) (see all 97)
tumors	78.56	1027	12792888 (6), 10931462 (6), 12872447 (6), 15966178 (6) (see all 99)
cancer	72.75	247	9030251 (4), 1959989 (3), 7812982 (3), 9000576 (2) (see all 99)
colon cancer	64.95	54	19150257 (2), 11212250 (2), 14560994 (2), 16533812 (2) (see all 41)
carcinoma squamous cell	62.36	107	10445528 (6), 17203174 (4), 9440786 (3), 11277421 (2) (see all 73)
breast cancer	61.10	158	11872638 (4), 12142081 (3), 17941827 (3), 11748377 (3) (see all 94)
carcinoma	59.36	162	9607584 (6), 8883416 (5), 9236898 (4), 17384651 (3) (see all 99)
colon carcinoma	58.71	45	10782880 (3), 15601469 (2), 9618491 (2), 15165036 (2) (see all 30)
prostate cancer	58.45	82	12151346 (6), 16281084 (3), 14743466 (3), 15077174 (3) (see all 52)
glioblastoma	56.24	45	10328545 (7), 9307270 (3), 10757313 (3), 8662996 (3) (see all 24)

About this table

2 PharmGKB disease relationships for CDKN1A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	CO FA	12973835 14578462
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Human Gene Mutation Database: CDKN1A
Genetic Association Database: CDKN1A
Human Genome Epidemiology Navigator: CDKN1A (66 documents)
Tumor Gene Database: CDKN1A

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2718 PubMed articles for CDKN1A gene (see all 2718 ):

The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. (PubMed id 7753561)^{1, 3, 4} Jiang H....Fisher P.B. (1995)
Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan. (PubMed id 16289646)^{1, 3, 6} Lai K.C....Tsai F.J. (2005)
Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15. (PubMed id 15960923)^{1, 3, 6} Soto Martinez J.L....Lopez-Nevot M.A. (2005)
Waf-1 (p21) and p53 polymorphisms in breast cancer. (PubMed id 11815410)^{1, 3, 6} Keshava C....Weston A. (2002)
Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women. (PubMed id 11179504)^{1, 3, 6} Harima Y....Ohnishi T. (2001)
Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. (PubMed id 10753973)^{1, 3, 4} Scott M.T.... Ball K.L. (2000)
Gene-gene and gene-environmental interactions of p53, p21, and IRF-1 polymorphisms in Korean women with cervix cancer. (PubMed id 14764039)^{1, 3, 6} Lee J.E....Park J.S. (2004)
p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer. (PubMed id 15598783)^{1, 3, 6} Huang S.P....Huang C.H. (2004)
p21 gene codon 31 polymorphism is associated with bladder cancer. (PubMed id 12474524)^{1, 3, 6} Chen W.C....Tsai F.J. (2002)
p21 is a universal inhibitor of cyclin kinases. (PubMed id 8259214)^{1, 3, 4} Xiong Y.... Beach D. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1026	HGNC: 1784	AceView: CDKN1A	Ensembl:ENSG00000124762	euGenes: HUgn1026
ECgene: CDKN1A	H-InvDB: CDKN1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDKN1A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdkn1a/

Licensable Technologies for CDKN1A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDKN1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDKN1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDKN1A		Antibodies for CDKN1A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDKN1A		Small molecules for CDKN1A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDKN1A)
	Antibodies (CDKN1A)
	Chimera RNAi (CDKN1A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDKN1A (p21Cip1)

	Recombinant Proteins (p21)
	Antibodies (p21)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CDKN1A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDKN1A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDKN1A Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CDKN1A Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for CDKN1A

Summaries
for CDKN1A

Genomic Location
for CDKN1A

Proteins
for CDKN1A

Protein Domains/
Families
for CDKN1A

Gene Function
for CDKN1A

Pathways & Interactions
for CDKN1A

Drugs & Compounds
for CDKN1A

Transcripts
for CDKN1A

Expression
for CDKN1A

Orthologs
for CDKN1A

Paralogs
for CDKN1A

SNPs/Variants
for CDKN1A

Disorders & Mutations
for CDKN1A

Medical News
for CDKN1A

Publications
for CDKN1A

Search for CDKN1A

Genome Databases showing CDKN1A

Other Databases showing CDKN1A

Specialized Databases showing CDKN1A

Licensable Technologies
for CDKN1A

Services
for CDKN1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDKN1A (Gene Symbol)
CAP20
CDKN1
CIP1
MDA-6
MDA6
OTTHUMP00000016298
P21
PIC1
SDI1
WAF1
p21
p21CIP1
p21Cip1/Waf1
CDK-interacting protein 1
CDK-interaction protein 1
DNA synthesis inhibitor
Melanoma differentiation-associated protein 6
cyclin-dependent kinase inhibitor 1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
melanoma differentiation associated protein 6
wild-type p53-activated fragment 1

CDKN1A Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor CDKN1A

Summariesfor CDKN1A

Genomic Locationfor CDKN1A

Proteinsfor CDKN1A

Protein Domains/Familiesfor CDKN1A

Gene Functionfor CDKN1A

Pathways & Interactionsfor CDKN1A

Drugs & Compoundsfor CDKN1A

Transcriptsfor CDKN1A

Expression for CDKN1A

Orthologsfor CDKN1A

Paralogsfor CDKN1A

SNPs/Variantsfor CDKN1A

Disorders & Mutationsfor CDKN1A

Medical Newsfor CDKN1A

Publicationsfor CDKN1A

Search for CDKN1A

Genome Databases showing CDKN1A

Other Databases showing CDKN1A

Specialized Databases showing CDKN1A

Licensable Technologiesfor CDKN1A

Servicesfor CDKN1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDKN1A

Summaries
for CDKN1A

Genomic Location
for CDKN1A

Proteins
for CDKN1A

Protein Domains/
Families
for CDKN1A

Gene Function
for CDKN1A

Pathways & Interactions
for CDKN1A

Drugs & Compounds
for CDKN1A

Transcripts
for CDKN1A

Expression
for CDKN1A

Orthologs
for CDKN1A

Paralogs
for CDKN1A

SNPs/Variants
for CDKN1A

Disorders & Mutations
for CDKN1A

Medical News
for CDKN1A

Publications
for CDKN1A

Licensable Technologies
for CDKN1A

Services
for CDKN1A