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CDKL5 Gene

protein-coding   GIFtS: 65
GCID: GC0XP018443

Cyclin-Dependent Kinase-Like 5

(Previous name: serine/threonine kinase 9)
(Previous symbol: STK9)
  See CDKL5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase-Like 51 2     EIEE22 5
STK91 2 3 5     ISSX2 5
Serine/Threonine Kinase 91 2     Cyclin Dependent Kinase 5 Transcript2
Serine/Threonine-Protein Kinase 92 3     EC 2.7.118
EC 2.7.11.223 8     

External Ids:    HGNC: 114111   Entrez Gene: 67922   Ensembl: ENSG000000080867   OMIM: 3002035   UniProtKB: O760393   

Export aliases for CDKL5 gene to outside databases

Previous GC identifers: GC0XP017109 GC0XP017645 GC0XP017805 GC0XP018203 GC0XP018353 GC0XP016199


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKL5 Gene:
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase
activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known
as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDKL5 Gene:
CDKL5 (cyclin-dependent kinase-like 5) is a protein-coding gene. Diseases associated with CDKL5 include epileptic encephalopathy, early infantile, 2, and cdkl5-related angelman-like syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is CDKL1.

UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039
Function: Mediates phosphorylation of MECP2

Gene Wiki entry for CDKL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKL5 gene promoter:
         Sox5   HFH-1   Cart-1   FOXD3   Hlf   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKL5 promoter sequence
   Search Chromatin IP Primers for CDKL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.13   HGNC cytogenetic band: Xp22

CDKL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKL5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP018443:  view genomic region     (about GC identifiers)

Start:
18,443,703 bp from pter      End:
18,671,749 bp from pter
Size:
228,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039 (See protein sequence)
Recommended Name: Cyclin-dependent kinase-like 5  
Size: 1030 amino acids; 115538 Da
Subunit: Interacts with MECP2
Caution: It is uncertain whether Met-1 or Met-10 is the initiator
Sequence caution: Sequence=CAA61445.1; Type=Frameshift; Positions=415;
1 PDB 3D structure from and Proteopedia for CDKL5:
4BGQ (3D)    
Secondary accessions: G9B9X4 Q14198 Q5H985 Q8IYC7 Q9UJL6
Alternative splicing: 2 isoforms:  O76039-1   O76039-2   (Predominant transcript in brain)

Explore the universe of human proteins at neXtProt for CDKL5: NX_O76039

Explore proteomics data for CDKL5 at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDKL5 (O76039) (see all 6)
     WSVGCIL  SEIDQLF  KLYLVFE  PYGKSVD 


    See CDKL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032420.1  NP_003150.1  

    ENSEMBL proteins: 
     ENSP00000369332   ENSP00000369325  

    CDKL5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase-like 5
    Cyclin-dependent kinase-like (CDKL) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O76039

    ProtoNet protein and cluster: O76039

    UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDKL5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDKL5_HUMAN, O76039
    Function: Mediates phosphorylation of MECP2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA16935860
    GO:0004674protein serine/threonine kinase activity TAS9721213
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IDA16935860
         
    Find genes that share ontologies with CDKL5           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDKL5:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death in HCC-19  Increased colony dispersion (i 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdkl5):
     behavior/neurological  nervous system  taste/olfaction 

    Find genes that share phenotypes with CDKL5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdkl5tm1.1Joez for CDKL5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKL5
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    miRTarBase miRNAs that target CDKL5:
    hsa-mir-222-3p (MIRT046657)

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    Sino Biological Human cDNA Clone for CDKL5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDKL5_HUMAN, O76039: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0032587colocalizes with ruffle membrane ISS--
    GO:0032839dendrite cytoplasm ISS--

    Find genes that share ontologies with CDKL5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDKL5 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37
    2BDNF signaling pathway
    BDNF signaling pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDKL5
        Sperm Motility

    1 BioSystems Pathway for CDKL5
        BDNF signaling pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDKL5
    Interactions:

        Search GeneGlobe Interaction Network for CDKL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CDKL5 (O760392, 3 ENSP000003693254) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110107 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111019 I2D: score=3 STRING: ENSP00000357656
    MECP2P516083, ENSP000003955354I2D: score=1 STRING: ENSP00000395535
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    MGMTENSP000003021114STRING: ENSP00000302111
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration ISS--
    GO:0006468protein phosphorylation TAS9721213
    GO:0032855positive regulation of Rac GTPase activity ISS--
    GO:0045773positive regulation of axon extension ISS--
    GO:0046777protein autophosphorylation IDA16935860

    Find genes that share ontologies with CDKL5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKL5

    2 HMDB Compounds for CDKL5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDKL5 gene (2 alternative transcripts): 
    NM_001037343.1  NM_003159.2  

    Unigene Cluster for CDKL5:

    Cyclin-dependent kinase-like 5
    Hs.659851  [show with all ESTs]
    Unigene Representative Sequence: BC036091
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379996(uc022btn.1 uc004cym.3) ENST00000379989(uc004cyn.3)
    ENST00000463994
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CDKL5

    Additional mRNA sequence: 

    AK056879.1 AK307444.1 AY217744.1 BC010966.1 BC036091.1 HQ171445.1 X89059.1 Y15057.1 

    4 DOTS entries:

    DT.409032  DT.97771331  DT.95234867  DT.75136827 

    22 AceView cDNA sequences:

    NM_003159 AA398911 AY217744 BC010966 Y15057 AI569744 CD675032 AK056879 
    W07775 AI582736 BI559845 CB153498 BX096833 BE831003 BC036091 X89059 
    AL704691 AA403214 AI286150 N80713 BF679133 AA228740 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDKL5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -                                                                           
    SP2:        -     -     -     -     -                                                                           
    SP3:                                -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CDKL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAACCAA
    CDKL5 Expression
    About this image


    CDKL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CDKL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659851

    UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039
    Tissue specificity: Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDKL5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkl51 , 5 cyclin-dependent kinase-like 51, 5 89.38(n)1
    95.8(a)1
      X (73.95 cM)5
    3822531  NM_001024624.21  NP_001019795.11 
     1607843085 
    chicken
    (Gallus gallus)
    Aves CDKL51 cyclin-dependent kinase-like 5 79.68(n)
    83.54(a)
      428001  XM_425571.3  XP_425571.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDKL56
    cyclin-dependent kinase-like 5
    75(a)
    1 ↔ 1
    3(122890920-123000894)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.228262 Xenopus laevis transcribed sequence with strong similarity more 84.46(n)    BJ059534.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdkl51 cyclin-dependent kinase-like 5 65.86(n)
    68.02(a)
      559341  NM_001130771.1  NP_001124243.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68006
    --
    32(a)
    1 → many
    3R(17601860-17602935)
    worm
    (Caenorhabditis elegans)
    Secernentea dyf-186
    Protein DYF-18 (dyf-18) mRNA, complete cds
    31(a)
    1 → many
    IV(11798665-11801088) WBGene00010349
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN286
    Serine/threonine protein kinase, subunit of the tr...
    31(a)
    1 → many
    IV(267698-268699) YDL108W


    ENSEMBL Gene Tree for CDKL5 (if available)
    TreeFam Gene Tree for CDKL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKL5 gene
    CDKL12  CDK202  CDKL22  CDKL32  CDK72  CDKL42  
    17 SIMAP similar genes for CDKL5 using alignment to 1 protein entry:     CDKL5_HUMAN:
    CDK2    CDK3    CDK7    CDKL2    PCTK1    MAPK1
    CDK6    CDK4    CDK10    GSK3B    MAPK12    MAPK14
    MAPK11    MAPK13    CDK9    MAPK8    MOK

    Find genes that share paralogs with CDKL5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKL5 (see all 2742)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0580284
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580282 T I mis40--------
    VAR_0580254
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580252 H R mis40--------
    VAR_0580224
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580222 A V mis40--------
    VAR_0580304
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580302 N T mis40--------
    VAR_0376354
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0376352 P L mis40--------
    VAR_0419984
    An ovarian serous carcinoma sample4--see VAR_0419982 P Q mis40--------
    VAR_0419974
    A metastatic melanoma sample4--see VAR_0419972 A T mis40--------
    VAR_0365784
    A colorectal cancer sample4--see VAR_0365782 N H mis40--------
    VAR_0580294
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580292 C Y mis40--------
    VAR_0235614
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0235612 R S mis40--------
    VAR_0580234
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580232 I N mis40--------
    VAR_0580244
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580242 I T mis40--------
    VAR_0580274
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580272 L P mis40--------
    VAR_0580324
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580322 V M mis40--------
    VAR_0235604
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0235602 C F mis40--------
    VAR_0580264
    Epileptic encephalopathy, early infantile, 2 (EIEE2)4--see VAR_0580262 R P mis40--------
    rs1224601591,2
    Cpathogenic118496083(+) TGTGGC/TGATCA 4 A V mis10--------
    rs626412351,2
    Cpathogenic118507010(+) AAACAA/C/TTGTGG 6 N T I mis10--------
    rs1224601571,2
    Cpathogenic118513529(+) ACTGTG/TTGACT 4 C F mis10--------
    rs617497001,2
    Cpathogenic118515911(+) ACCAGA/TTGGTA 4 R S mis10--------
    rs2676067151,2
    Cpathogenic118515919(+) GTATCA/C/GGTCCC 6 Q P R mis10--------
    rs2676067131,2
    Cpathogenic118530086(+) CTTGAC/TAGAAC 4 T I mis10--------
    rs2676067141,2
    Cpathogenic118530095(+) ACAGTA/GTTTGA 4 Y C mis10--------
    rs1224601581,2
    Cpathogenic118560060(+) AGAGCC/TAGCCA 4 Q * stg10--------
    rs1998147421,2
    Cuntested118496126(+) TATATA/GTATAT 2 -- int10--------
    rs48252611,2
    C,F,A,Huntested118511336(+) AAGCTA/CTGTAT 2 -- int120Minor allele frequency- N:0.00NS EA NA 2195
    rs2676084481,2
    Cuntested118511392(+) TTACGA/GGCCTA 2 -- int10--------
    rs2676084781,2
    Cuntested118513559(+) TTAAGC/TCCTGG 2 -- int10--------
    rs2676084931,2
    Cuntested118515918(+) GGTATA/C/TGGTCC 4 R W mis10--------
    rs750579281,2
    Cuntested118519522(+) ATAATC/GTCTTC 2 -- int10--------
    rs617539771,2
    Cuntested118535840(+) AGAACC/TGCCAC 4 R C mis10--------
    rs2018932871,2
    Cuntested118536033(+) CCAAAC/TTGCGG 4 T I mis10--------
    rs2676083951,2
    Cuntested118536185(+) CACGTC/TGAACC 4 R * stg10--------
    rs1448785641,2
    Cuntested118536402(+) GAGCAT/CAGGGC 4 /T /I mis11Minor allele frequency- C:0.00NA 4546
    rs1478197581,2
    Cuntested118540577(+) ACCCAA/GTCTCC 2 -- int10--------
    rs354781501,2,,4
    C,F,Huntested118551548(+) ATCTCA/CAACAG 4 Q P mis13Minor allele frequency- C:0.03NS NA 3092
    rs2676086561,2
    Cuntested118551553(+) AAACAA/C/GTAAGT 4 -- spd10--------
    rs37524841,2
    C,F,A,Huntested118551670(+) CATTTA/TTGCAC 2 -- int124--NS EA NA WA CSA 2550
    rs2021535511,2
    Cuntested118582150(+) CAAACC/TGAGCC 4 R * stg10--------
    rs356933261,2,,4
    C,Funtested118585130(+) TCTTCA/GTGAGA 4 M V mis19Minor allele frequency- G:0.94NA NS EA WA 5042
    rs360221831,2
    C,F,Huntested118585138(+) AGACAC/G/TGTTAT 6 H Q mis1 syn16NA NS 5082
    rs1391551101,2
    C,Funtested118585219(+) CTGACA/C/GGGCAA 6 T syn11NA 4540
    rs1403182051,2
    --18355496(+) ACTTCC/TGGTTC 1 -- us2k10--------
    rs1831873361,2
    --18355530(+) AAAATG/TATTCA 1 -- us2k10--------
    rs731915141,2
    C,F--18355628(+) TGGATC/TCACGT 1 -- us2k10--------
    rs1877765431,2
    --18355714(+) TGCCTC/GTGACT 1 -- us2k10--------
    rs1926906591,2
    --18355998(+) CGTGCC/TTTTCC 1 -- us2k10--------
    rs1839261741,2
    --18356169(+) TCATCA/CTCCTT 1 -- us2k10--------
    rs1511717911,2
    C--18356215(+) CATTTC/GTACTG 1 -- us2k10--------
    rs1391151061,2
    --18356359(+) GCTGCA/TGTGTA 1 -- us2k10--------
    rs1877113231,2
    --18356744(+) ACCCCC/GGCAGC 1 -- us2k10--------
    rs1922606291,2
    --18356767(+) AGTCAC/TGATCT 1 -- us2k10--------
    rs1844070211,2
    --18357013(+) AACCCC/GAGGAC 1 -- us2k10--------
    rs1890186411,2
    --18357047(+) CTACCA/GGAAGG 1 -- us2k10--------
    rs1918648981,2
    --18357048(+) TACCAG/TAAGGG 1 -- us2k10--------
    rs1848657421,2
    --18357158(+) CGCTTC/TTGCTA 1 -- us2k10--------
    rs1893245811,2
    --18357164(+) TGCTAC/GAGGGC 1 -- us2k10--------
    rs1807041091,2
    --18357409(+) GCGCCG/TGTTCC 1 -- int10--------
    rs1871881701,2
    --18357412(+) CCGGTC/TCCCCC 1 -- int10--------
    rs37888151,2
    C,F,H--18358228(-) TTAAAT/ATCCAG 1 -- int14Minor allele frequency- A:0.09NS EA 418
    rs1892131511,2
    --18358280(+) CTGTGC/TATCTG 1 -- int10--------
    rs1815891391,2
    C--18358331(+) AAAAGA/TTTACA 1 -- int10--------
    rs1450225551,2
    C--18358369(+) CAGAAA/GCAGGA 1 -- int10--------
    rs1859989341,2
    --18358673(+) TTTTTA/TAAAAA 1 -- int10--------
    rs1904892311,2
    --18358911(+) GTTGGG/TGGGGA 1 -- int10--------
    rs1409738461,2
    C--18359161(+) TCTTTA/GAATTG 1 -- int10--------
    rs1814337301,2
    C--18359226(+) TCAAAA/C/GAGTTG 1 -- int10--------
    rs1863441941,2
    --18359352(+) TTTTCC/TTGGCT 1 -- int10--------
    rs1908019721,2
    C--18359374(+) TTTATA/TCATGA 1 -- int10--------
    rs1827114311,2
    --18359550(+) CTCCCA/C/GTTGAA 1 -- int10--------
    rs1879683141,2
    --18359931(+) ATTGGC/GTGTAA 1 -- int10--------
    rs1911821311,2
    --18360390(+) TCTTTA/GTCATC 1 -- int10--------
    rs1832941651,2
    --18360569(+) TTGATA/CGTTTT 1 -- int10--------
    rs2009700961,2
    --18360579(+) TAGAA-/TTTTTT 1 -- int10--------
    rs1876662661,2
    --18360670(+) CTTCAC/GACTGA 1 -- int10--------
    rs1930876151,2
    --18360708(+) GTGGGC/TGTGAA 1 -- int10--------
    rs1847979471,2
    C--18360789(+) AAGTTA/GTTTAT 1 -- int10--------
    rs1880723771,2
    --18361240(+) GACACC/TGGGTC 1 -- int10--------
    rs1924011931,2
    --18361410(+) GGCGGC/GGTCTC 1 -- int10--------
    rs2006627361,2
    C--18361536(-) AGGAAC/TTCAAA 1 -- int10--------
    rs1835074071,2
    --18361718(+) ACTTTC/TCTAAC 1 -- int10--------
    rs1467424061,2
    C--18361847(+) GGACTG/TTGATT 1 -- int10--------
    rs1880896851,2
    --18361877(+) AGGCTA/TCGAAG 1 -- int10--------
    rs1412284971,2
    --18362127(+) TCAAAC/TGATTC 1 -- int10--------
    rs1820327041,2
    --18362325(+) CCACCA/GCTTGT 1 -- int10--------
    rs1846712631,2
    --18362360(+) TCTGAA/GAATTT 1 -- int10--------
    rs1889807561,2
    --18362663(+) GGTCTC/TGAACT 1 -- int10--------
    rs731915161,2
    C--18362742(+) CCTGGC/TGGTGA 1 -- int10--------
    rs1432601121,2
    --18362840(+) AAAACG/TTAACA 1 -- int10--------
    rs1482987931,2
    C--18362866(+) GATTAA/CAATCA 1 -- int10--------
    rs59556211,2
    C,F,A,H--18362969(+) CACAGA/GTGGGA 1 -- int118Minor allele frequency- G:0.21NS EA NA WA CSA 1688
    rs1864670951,2
    --18363009(+) CTTTTC/TTTTTT 1 -- int10--------
    rs1912945401,2
    C--18363034(+) GTCTCG/TCTCTG 1 -- int10--------
    rs1504245971,2
    C--18363270(+) CAAAGA/TGCTGG 1 -- int10--------
    rs1812327651,2
    --18363298(+) GATTTA/CTTTAT 1 -- int10--------
    rs1854332291,2
    --18363318(+) GAGGTA/GTACTT 1 -- int10--------
    rs1382794801,2
    C--18363335(+) CCATAA/GAACTC 1 -- int10--------
    rs1439626021,2
    C--18363451(+) CTCCTA/GTCAAT 1 -- int10--------
    rs1473263741,2
    C--18363515(+) GACAGA/GGTCTC 1 -- int10--------
    rs1898244001,2
    --18363588(+) AGGCTC/TGAGCG 1 -- int10--------
    rs2013554731,2
    --18363657(+) GCTAA-/TTTC  
            
    TTTCT
    1 -- int10--------
    rs1835308911,2
    --18363906(+) ACCCCC/TGACAT 1 -- int10--------
    rs1877166561,2
    --18364180(+) AAAAGA/TTGTCT 1 -- int10--------
    rs126886811,2
    H--18364268(+) tgcagG/Tctcca 1 -- int10--------
    rs1915840211,2
    C--18364364(+) TTTGTA/GTTTTG 1 -- int10--------
    rs1835532651,2
    --18364533(+) CCAGGC/TGTGGG 1 -- int10--------
    rs1880368781,2
    --18364855(+) CGGCCA/GGGCCT 1 -- int10--------
    rs1929804021,2
    --18365017(+) TCCCAA/GCTACT 1 -- int10--------
    rs1838996281,2
    --18365039(+) GGCAGA/GAGAAT 1 -- int10--------
    rs1868003611,2
    --18365127(+) ACTCCG/TTTTAA 1 -- int10--------
    rs1911253591,2
    --18365132(+) GTTTAA/TATAAA 1 -- int10--------
    rs1847265801,2
    --18365145(+) AAAAAA/TTTTTC 1 -- int10--------
    rs1905320811,2
    --18365509(+) TGCCTA/CATGCG 1 -- int10--------
    rs1409810601,2
    C--18365795(+) ATGTTA/GTTTTT 1 -- int10--------
    rs1817930831,2
    --18366000(+) ACGGCA/TCTGGT 1 -- int10--------
    rs1433065161,2
    --18366001(+) CGGCAC/GTGGTC 1 -- int10--------
    rs1854383401,2
    C--18366026(+) TACTGC/TCAGTT 1 -- int10--------
    rs1899113161,2
    --18366380(+) GGCACA/GCACCT 1 -- int10--------
    rs1815856231,2
    --18366514(+) AAAAAA/GGAAGA 1 -- int10--------
    rs1856562031,2
    --18366523(+) GAAAAA/CGATTT 1 -- int10--------
    rs172741901,2
    C,F,H--18366718(+) TTCCTC/GATGAG 1 -- int115Minor allele frequency- N:0.00NA NS EA 1798
    rs1483987781,2
    C--18367140(+) CTGCCC/TTCAAA 1 -- int10--------
    rs1883150971,2
    --18367206(+) GCAGTA/GGTGCG 1 -- int10--------
    rs1806735061,2
    --18367315(+) GCTAAG/TTTTTG 1 -- int10--------
    rs1425719261,2
    --18367323(+) TTGTAC/TTTTCA 1 -- int10--------
    rs1162466511,2
    C--18367557(+) CCAAGC/TATAAC 1 -- int10--------
    rs1865030411,2
    --18367648(+) AACACA/GTTGTT 1 -- int10--------
    rs1921419351,2
    --18367863(+) TGGAAC/GAGGTA 1 -- int10--------
    rs1838055141,2
    --18367997(+) AACAGC/GGTAGG 1 -- int10--------
    rs1399218521,2
    --18368083(+) ATGAGA/GAGGAC 1 -- int10--------
    rs1433352121,2
    --18368131(+) GTGCAA/CATGTG 1 -- int10--------
    rs59556221,2
    H--18368314(+) catttC/Ttacaa 1 -- int14Minor allele frequency- T:0.00NS EA 376
    rs1870796691,2
    --18368480(+) ACTCAA/CAAAAA 1 -- int10--------
    rs1915435491,2
    --18368522(+) TCTAAA/GACGAC 1 -- int10--------
    rs1467241201,2
    C--18368590(+) AAAGGC/TTTAGT 1 -- int10--------
    rs1112933791,2
    C,F--18368665(+) GAGGGC/GTGTGA 1 -- int11Minor allele frequency- G:0.00NA 1
    rs1868418421,2
    --18369207(+) ATTGTA/GTAGGA 1 -- int10--------
    rs1913703741,2
    --18369296(+) CTGTTA/GAACAT 1 -- int10--------
    rs1821019691,2
    --18369476(+) TCAAGC/TCTTTC 1 -- int10--------
    rs1875539131,2
    --18369529(+) GCCCAC/GTGTTC 1 -- int10--------
    rs1932843411,2
    C--18369546(+) ACATAC/TACGAA 1 -- int10--------
    rs1855542171,2
    --18369926(+) CAGGCG/TTGAGC 1 -- int10--------
    rs1903915921,2
    --18370101(+) GCCGCA/GGTGGC 1 -- int10--------
    rs1919820801,2
    --18370353(+) GGCGAC/TAGAGC 1 -- int10--------
    rs1841820681,2
    --18370394(+) AAAAGA/GCAAGG 1 -- int10--------
    rs1885583601,2
    --18370434(+) AATTGA/CAAGAA 1 -- int10--------
    rs1493972551,2
    C--18370629(+) TTTTG-/CGCCCC 1 -- int10--------
    rs59094761,2
    H--18370641(+) CCCCCG/CCCCCC 1 -- int14Minor allele frequency- C:0.00NS EA 418
    rs1503698961,2
    C--18370967(+) GTTCTA/GTTCCA 1 -- int10--------
    rs1809264761,2
    --18371162(+) CTCACA/GCTATA 1 -- int10--------
    rs1862159151,2
    --18371292(+) GGCTCC/GCACCT 1 -- int10--------
    rs1997961551,2
    C--18371422(+) TCTCC-/AAAAAA 1 -- int10--------
    rs1890840681,2
    --18371452(+) ATACTA/CTACTG 1 -- int10--------
    rs1440005101,2
    --18371757(+) GATAGC/TGTTTT 1 -- int10--------
    rs1468513121,2
    --18371826(+) GTAGTC/GTATTT 2 -- int1 us2k10--------
    rs59559661,2
    C,F--18372245(+) agagaT/Cggcgt 2 -- int1 us2k11Minor allele frequency- C:0.00WA 2
    rs1825892481,2
    --18372256(+) TTCACC/TGTGTT 2 -- int1 us2k10--------
    rs1415949571,2
    --18372472(+) TTGGCA/GCAAAG 2 -- int1 us2k10--------
    rs797461341,2
    C--18372535(+) TGTCCG/TAAAGA 2 -- int1 us2k10--------
    rs1379300081,2
    C--18372553(+) TAATAC/TGAATT 2 -- int1 us2k10--------
    rs1494455441,2
    --18372765(+) GAAGCC/TGAGTC 2 -- int1 us2k10--------
    rs1870169151,2
    --18372885(+) GTCCCC/GCTACT 2 -- int1 us2k10--------
    rs1439582381,2
    --18373140(+) GTGGGA/GGGGCT 2 -- int1 us2k10--------
    rs1918872971,2
    --18373165(+) TGTTAA/GTCATG 2 -- int1 us2k10--------
    rs1124496141,2
    C--18373414(+) TTCTGT/CTCTTA 2 -- int1 us2k11Minor allele frequency- C:0.00CSA 1
    rs1827907991,2
    C--18373458(+) GAGGGA/GTGATA 2 -- int1 us2k10--------
    rs1855381311,2
    --18373499(+) AGTTTC/TAGGCC 2 -- int1 us2k10--------
    rs1902478661,2
    --18373561(+) GAATCC/TTACCC 2 -- int1 us2k10--------
    rs1824629301,2
    --18373636(+) GGGTAC/GAAGTA 2 -- int1 us2k10--------
    rs1880618121,2
    C--18373663(+) TCACAC/GTGAAG 2 -- int1 us2k10--------
    rs22837221,2
    C,H--18373744(-) GGGGGT/CGGGCA 2 -- int1 us2k11Minor allele frequency- C:0.00NS 120
    rs1922699931,2
    --18373745(+) GCCCAC/GCCCCA 2 -- int1 us2k10--------
    rs1840716351,2
    --18373964(+) CTGTAC/TTCTCC 2 -- int1 ut510--------
    rs1885813041,2
    --18373976(+) ACAGGC/TGAGCA 2 -- int1 ut510--------
    rs726160651,2
    C--18374005(+) CCCTTC/TAGGTA 2 -- int1 ut510--------
    rs1922396321,2
    --18374108(+) AGTTTC/TGCTCT 2 -- int10--------
    rs2006051901,2
    C--18374372(+) CGCCT-/TAGCGC 2 -- int10--------
    rs1117919931,2
    C--18374375(+) GCCTAA/GCGCTC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs1843968671,2
    C--18374420(+) AGTTCA/GGCTCT 2 -- int10--------
    rs1890049011,2
    --18374496(+) ATGAGC/TGTTTC 2 -- int10--------
    rs1918718091,2
    --18374579(+) ACCGTC/TAGCCC 2 -- int10--------
    rs1427045471,2
    --18374720(+) TCTTCC/TTTCTT 2 -- int10--------
    rs1847461461,2
    --18375044(+) AGCCCA/CGTACC 2 -- int10--------
    rs1510021091,2
    C--18375104(+) GTAGAA/GGGGGA 2 -- int10--------
    rs1894954521,2
    --18375202(+) TTACAC/TAGGTA 2 -- int10--------
    rs1806855831,2
    --18375331(+) CCCCAA/GTTTCT 2 -- int10--------
    rs1404470941,2
    --18375362(+) AGTTCC/TTATCA 2 -- int10--------
    rs1857790131,2
    C--18375537(+) ATTTCA/GTTGTA 2 -- int10--------
    rs113454491,2
    C--18375645(+) TCCTTG/-TTTTT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs117983931,2
    C,H--18375826(+) atggaA/Cccatt 2 -- int16Minor allele frequency- C:0.00NS EA NA 422
    rs1891960981,2
    C--18375891(+) TTTCTA/C/GTCTCT 2 -- int10--------
    rs1499725211,2
    --18375977(+) TTGAGC/GGTTTC 2 -- int10--------
    rs782832211,2
    C--18376187(+) TGAGCC/TACTGT 2 -- int10--------
    rs1818340021,2
    --18376191(+) CCACTA/GTGCCC 2 -- int10--------
    rs1859834751,2
    --18376268(+) TTCTTC/TCAAAT 2 -- int10--------
    rs1424827631,2
    --18376338(+) AAGTCC/GTCTTT 2 -- int10--------
    rs1465221601,2
    --18376359(+) CTTAGC/GTGTAA 2 -- int10--------
    rs1904999041,2
    C--18376403(+) CTTCTC/TCCCTC 2 -- int10--------
    rs1815818911,2
    --18376430(+) TCTCCA/GTGTGG 2 -- int10--------
    rs1392599071,2
    --18376455(+) CAATTG/TAACGA 2 -- int10--------
    rs1861812701,2
    --18376501(+) TGGTCA/TAGTTT 2 -- int10--------
    rs1910311581,2
    --18376583(+) CTCCAG/TCACCT 2 -- int10--------
    rs1824482621,2
    --18376951(+) GCCACC/TGCATC 2 -- int10--------
    rs1891103461,2
    --18377169(+) CACATC/GTCAAG 2 -- int10--------
    rs1489741331,2
    C--18377222(+) TCCCCC/TGTGCT 2 -- int10--------
    rs1911658681,2
    --18377411(+) AAAATA/GAATTA 2 -- int10--------
    rs1832974691,2
    --18377521(+) TGATTG/TAGAGG 2 -- int10--------
    rs128524641,2
    C--18377662(+) AGAAAA/GTAGgc 2 -- int10--------
    rs1876718711,2
    --18377694(+) AGGCCA/GAGGTG 2 -- int10--------
    rs125574431,2
    H--18377772(+) aaaatA/Ccaaaa 2 -- int10--------
    rs1921188711,2
    --18377877(+) AGTCCC/GTGAGC 2 -- int10--------
    rs2010535451,2
    --18377941(+) AGAAA-/AAA   
       AAAAC
    AAAAA
    2 -- int10--------
    rs1848976691,2
    --18378001(+) CCCCCA/GCCTTG 2 -- int10--------
    rs768361041,2
    C--18378182(+) GGACTA/GTAATC 2 -- int10--------
    rs1878723391,2
    --18378253(+) AGGGAA/GTATGC 2 -- int10--------
    rs1481565761,2
    --18378257(+) AGTATA/GCTGTT 2 -- int10--------
    rs1420049781,2
    --18378543(+) AGGAGA/CCTTAG 2 -- int10--------
    rs784119211,2
    C--18378828(+) GTGCCC/TGGGTT 2 -- int10--------
    rs1927487311,2
    --18378902(+) CTTATA/GCCTAA 2 -- int10--------
    rs66540421,2
    C,F,H--18378971(+) AACTTC/TTCCCC 2 -- int1 trp312Minor allele frequency- T:0.09NS EA NA 1694
    rs1844936621,2
    --18379033(+) CTTCAA/GATTTT 2 -- int10--------
    rs65278511,2
    C,F,A,H--18379253(+) CTTTCC/TCTCCC 2 -- int1 trp316Minor allele frequency- T:0.32NS EA NA WA CSA 1982
    rs1880744961,2
    --18379769(+) ACTTCA/GTTTTC 2 -- int10--------
    rs1126105201,2
    C,F--18379799(+) CAAGAG/CAGATA 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1393258401,2
    C--18379810(+) GTGGGG/TTCTTG 2 -- int10--------
    rs1499181581,2
    C--18379843(+) GTTGCC/TAATGT 2 -- int10--------
    rs1820392861,2
    --18379862(+) ATATGA/GTTTAG 2 -- int10--------
    rs1441521851,2
    --18379972(+) AGTCTC/GTGCCC 2 -- int10--------
    rs117981011,2
    C,F,H--18380001(+) ACATCA/GTCTCT 2 -- int17Minor allele frequency- G:0.05NS NA 968
    rs1846832181,2
    --18380042(+) TATAGC/GTTCCT 2 -- int10--------
    rs1422187011,2
    --18380048(+) TTCCTA/GTACAA 2 -- int10--------
    rs1476746231,2
    --18380071(+) CTTGAC/TGTCTT 2 -- int10--------
    rs1889642351,2
    --18380356(+) TCCCTA/GCTTCC 2 -- int10--------
    rs21446021,2
    C,H--18380363(+) TTCCTC/TTATTT 2 -- int18Minor allele frequency- T:0.00NA EA NS 672
    rs1814695961,2
    --18380960(+) CTGTCC/TTCGTG 2 -- int10--------
    rs2007812401,2
    C--18381079(+) GCCCT-/CCCCCC 2 -- int10--------
    rs2007233871,2
    C--18381083(+) TCCCCC/TCTGCC 2 -- int10--------
    rs1423248401,2
    C--18381326(+) TCCTGA/CATTTT 2 -- int10--------
    rs1866459881,2
    --18381628(+) CGCCTC/TGGCCT 2 -- int10--------
    rs1447439071,2
    --18381706(+) AAGCAA/GATGCT 2 -- int10--------
    rs1478914141,2
    --18381788(+) GATATA/GTTGCT 2 -- int10--------
    rs1910365971,2
    --18381905(+) AAATAA/TCATAG 2 -- int10--------
    rs1405566141,2
    --18381952(+) CAGCAG/TTAAAT 2 -- int10--------
    rs1812353711,2
    --18381991(+) TTTGCC/TAGATT 2 -- int10--------
    rs1854203161,2
    --18382147(+) TATATA/TTATAG 2 -- int10--------
    rs1898326401,2
    --18382658(+) TAGAAA/GAATGC 2 -- int10--------
    rs1835404021,2
    --18382743(+) TGTGTA/GTTAAG 2 -- int10--------
    rs1877008851,2
    --18382833(+) TGCAAC/TGGCAT 2 -- int10--------
    rs1907242611,2
    --18382869(+) CTTCCA/GGGTTC 2 -- int10--------
    rs1833034071,2
    --18382897(+) CAGGCC/TCCCGA 2 -- int10--------
    rs1504676301,2
    C--18383159(+) ACTCTA/GTTGCC 2 -- int10--------
    rs1886049261,2
    --18383303(+) TTTTTC/GGTAGA 2 -- int10--------
    rs1927647311,2
    --18383305(+) TTTGGC/TAGAGA 2 -- int10--------
    rs1848813961,2
    --18383358(+) TCTCAA/GAATGA 2 -- int10--------
    rs1868063031,2
    --18383377(+) CCTCGG/TCCTCC 2 -- int10--------
    rs1492267791,2
    --18383563(+) TGATAC/TTGATT 2 -- int10--------
    rs1451557591,2
    C--18383696(+) ATTGTA/GTTAAT 2 -- int10--------
    rs1385340071,2
    C--18385075(+) GGATTA/GTAAGG 2 -- int10--------
    rs1911355751,2
    --18385104(+) ATGATA/GTGTAT 2 -- int10--------
    rs1453484721,2
    C--18385222(+) TTTTAA/GAACCA 2 -- int10--------
    rs1847084631,2
    --18385427(+) CGTGTC/TGTCTT 2 -- int10--------
    rs1892089801,2
    --18385646(+) GGTAGC/TCTTTA 2 -- int10--------
    rs1479965611,2
    --18385724(+) GAGTCC/TATAAT 2 -- int10--------
    rs1931680431,2
    C--18386023(+) ACTGCA/GTTGGC 2 -- int10--------
    rs1852980641,2
    --18386082(+) CCAAAG/TTGCTG 2 -- int10--------
    rs1901480821,2
    --18386108(+) GCCACC/TGTGCC 2 -- int10--------
    rs1416765921,2
    --18386362(+) CTTCTA/TCTCCT 2 -- int10--------
    rs1505748181,2
    C--18386719(+) TTCGAC/TGACTT 2 -- int10--------
    rs128342781,2
    H--18387229(+) CCGCTT/ACTGTA 2 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1814535521,2
    --18387393(+) TTCCTG/TTCCAA 2 -- int10--------
    rs1395576311,2
    --18387451(+) AGCACA/GTGACT 2 -- int10--------
    rs1856645161,2
    --18387864(+) TGGTCC/TACCCA 2 -- int10--------
    rs1883210741,2
    --18388093(+) CTATGA/TCTACA 2 -- int10--------
    rs1807617761,2
    --18388162(+) GTGGGA/GATATA 2 -- int10--------
    rs1429091501,2
    --18388323(+) AAATTA/CTTTTC 2 -- int10--------
    rs1864882471,2
    --18388384(+) TCTTCC/TTCTGC 2 -- int10--------
    rs1121923991,2
    F--18388435(+) ATTTTT/CCTCTT 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1474238081,2
    --18388463(+) TAATGC/TGTTAT 2 -- int10--------
    rs1839746991,2
    --18388464(+) AATGCG/TTTATT 2 -- int10--------
    rs59094771,2
    C,H--18388777(+) CTTTCA/CATTCC 2 -- int15Minor allele frequency- C:0.00NS EA NA 370
    rs1407174551,2
    C--18389002(+) ATGTTC/TATTGA 2 -- int10--------
    rs1869770051,2
    --18389015(+) ACTTTA/CTCTGT 2 -- int10--------
    rs1918093161,2
    --18389021(+) TCTGTC/GCGGAG 2 -- int10--------
    rs1825715691,2
    --18389092(+) AAACAA/TGGCTA 2 -- int10--------
    rs1868281221,2
    C--18389214(+) TGTTTG/TTTTTT 2 -- int10--------
    rs1913573661,2
    --18389859(+) GCTTAC/TAACTA 2 -- int10--------
    rs1820856011,2
    --18390112(+) TCTGTA/GTCTAC 2 -- int10--------
    rs1866016861,2
    --18390156(+) TGTGGC/TGGCAC 2 -- int10--------
    rs1931265081,2
    --18390350(+) GTTGCA/GCTGGC 2 -- int10--------
    rs1856712401,2
    --18390391(+) ACTAGC/TGGCTA 2 -- int10--------
    rs1445803341,2
    --18390499(+) GGGTTA/GGAAAA 2 -- int10--------
    rs59094791,2
    C,F,H--18390733(+) ATTCAA/GCGTGT 2 -- int18Minor allele frequency- G:0.01NS EA NA 880
    rs1485467961,2
    --18390834(+) TTGTCA/GTGCTG 2 -- int10--------
    rs59094801,2
    C,H--18390863(+) GGCCGG/AGCACC 2 -- int113Minor allele frequency- A:0.00NS EA WA NA CSA 430
    rs752548731,2
    C--18390906(+) AGGCTA/GAGGCA 2 -- int10--------
    rs1901482361,2
    C--18391124(+) CTGGGC/TGACAG 2 -- int10--------
    rs1930289291,2
    --18391277(+) AGCTTG/TCTTTC 2 -- int10--------
    rs782342761,2
    C--18391593(+) CTGGGA/G/TTTACA 2 -- int10--------
    rs1510998451,2
    C--18391605(+) GTGTGC/TGCCAC 2 -- int10--------
    rs2016362291,2
    C--18391726(+) GATCCA/GCCCGC 2 -- int10--------
    rs1842583241,2
    --18391729(+) CCGCCC/TGCCTC 2 -- int10--------
    rs2016612591,2
    --18391749(+) AATGT-/TGAG  
     ACAGGCG
    TGAGA
    2 -- int10--------
    rs1885438691,2
    --18391847(+) GGAAGC/TGGGGT 2 -- int10--------
    rs66330991,2
    H--18391859(+) ccgtaG/Aggggg 2 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1812073941,2
    --18391868(+) GGACCA/GTACTA 2 -- int10--------
    rs1854274241,2
    --18391967(+) CCATTA/GTCTAA 2 -- int10--------
    rs1410239191,2
    C--18391992(+) GCCCCA/GCCTCC 2 -- int10--------
    rs1894494221,2
    --18392046(+) CAGATC/GCAAAC 2 -- int10--------
    rs1823111631,2
    --18392140(+) TGCAGG/TGGTGT 2 -- int10--------
    rs1468635781,2
    C--18392338(+) CCTTGA/GCCTTC 2 -- int10--------
    rs1402385821,2
    C--18392429(+) GGCCCA/GTCATG 2 -- int10--------
    rs1452866391,2
    --18392520(+) AATTTC/TTCAGG 2 -- int10--------
    rs1379007641,2
    --18392612(+) TTACAA/GTGATT 2 -- int10--------
    rs1872270811,2
    --18392700(+) AATGAA/GTATCT 2 -- int10--------
    rs38196231,2
    C,F,H--18392761(-) AAGACC/TGGTAC 2 -- int19--NA NS EA 564
    rs1916039421,2
    --18393377(+) AGACCA/GATGAG 2 -- int10--------
    rs38196221,2
    C,F,H--18393419(-) CCTATC/TCCCAT 2 -- int115--NA NS EA 1826
    rs764566081,2
    C--18393423(+) GGATAG/TGAGGC 2 -- int10--------
    rs1474339391,2
    --18393572(+) ACCCGC/TGGTCT 2 -- int10--------
    rs1398105581,2
    --18393629(+) AATTCA/GTAAAC 2 -- int10--------
    rs2000665591,2
    --18393662(+) TTTGC-/GGTTTT 2 -- int10--------
    rs1827752841,2
    --18393663(+) TTGCGG/TTTTTT 2 -- int10--------
    rs736366811,2
    C--18393679(+) TTTTTC/TTTTTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1855239121,2
    --18393724(+) CCTGTG/TTGGCC 2 -- int10--------
    rs1902334901,2
    --18393747(+) TCCAAC/TGTGGC 2 -- int10--------
    rs1824473291,2
    --18393772(+) AGATTC/GGACAC 2 -- int10--------
    rs1437287021,2
    --18394083(+) AAAGTG/TTGAAA 2 -- int10--------
    rs1877673811,2
    --18394104(+) TAGACC/TTAATT 2 -- int10--------
    rs1909902331,2
    --18394151(+) AGTTAC/TGAGAA 2 -- int10--------
    rs1508326451,2
    --18394209(+) TGTGAA/GTATAT 2 -- int10--------
    rs1839226001,2
    --18394322(+) GATACC/TGGAGG 2 -- int10--------
    rs1888684691,2
    --18394383(+) TGGGCA/GGATCA 2 -- int10--------
    rs1929347691,2
    --18394480(+) GTGTGC/TGCCTG 2 -- int10--------
    rs1846694821,2
    --18394644(+) ATACCA/GGAAGC 2 -- int10--------
    rs1392465711,2
    C--18395169(+) ATTTGA/GGAAAC 2 -- int10--------
    rs1874500841,2
    --18395576(+) ATCTTC/TTTAAG 2 -- int10--------
    rs1919461331,2
    --18395740(+) TTATTA/GCCAAT 2 -- int10--------
    rs1500144661,2
    --18396019(+) CTGTTA/GATATC 2 -- int10--------
    rs59091841,2
    C,F,A,H--18396129(+) TACCAC/TTTTTT 2 -- int113Minor allele frequency- T:0.30NS EA NA 1975
    rs1892174801,2
    --18396197(+) GCAAAA/CACTTC 2 -- int10--------
    rs1807008241,2
    C--18396250(+) CCTTAC/TGTAAC 2 -- int10--------
    rs1856289821,2
    --18396365(+) AGTGCA/CTTTTC 2 -- int10--------
    rs1904884611,2
    --18396399(+) AATTAC/TTGACT 2 -- int10--------
    rs1452312541,2
    C--18396674(+) AGTTAA/GTATTT 2 -- int10--------
    rs43676971,2
    C,F,A,H--18396876(+) GTCCTA/GATCCA 2 -- int113Minor allele frequency- G:0.19NS EA NA 1978
    rs1468438241,2
    --18396952(+) GTATAC/TATTTT 2 -- int10--------
    rs1818245881,2
    --18397103(+) AAAAAA/TTTAGC 2 -- int10--------
    rs1859676001,2
    C--18397178(+) AATCCA/GGGAAG 2 -- int10--------
    rs173209001,2
    C,F,H--18397683(+) AAAATA/GATAGG 2 -- int18Minor allele frequency- N:0.00NA NS EA 630
    rs1904811701,2
    --18397729(+) ATTTCA/TACCTG 2 -- int10--------
    rs1813223091,2
    --18397737(+) CTGTTC/TTCAGT 2 -- int10--------
    rs1458782571,2
    C--18397837(+) TTTCTA/GAATTA 2 -- int1