Aliases for CDKL5 Gene
Aliases for CDKL5 Gene
External Ids for CDKL5 Gene
- HGNC: 11411
- Entrez Gene: 6792
- Ensembl: ENSG00000008086
- OMIM: 300203
- UniProtKB: O76039
Previous HGNC Symbols for CDKL5 Gene
- STK9
Previous GeneCards Identifiers for CDKL5 Gene
- GC0XP017109
- GC0XP017645
- GC0XP017805
- GC0XP018203
- GC0XP018353
- GC0XP016199
Summaries for CDKL5 Gene
-
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDKL5 Gene
CDKL5 (Cyclin Dependent Kinase Like 5) is a Protein Coding gene. Diseases associated with CDKL5 include Epileptic Encephalopathy, Early Infantile, 2 and Rett Syndrome. Among its related pathways are Sweet Taste Signaling and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL2.
UniProtKB/Swiss-Prot for CDKL5 Gene
-
Mediates phosphorylation of MECP2.
Additional gene information for CDKL5 Gene
- Monarch Initiative
- Search for CDKL5 at DataMed
- Search for CDKL5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL5 Gene
Genomics for CDKL5 Gene
GeneHancer (GH) Regulatory Elements for CDKL5 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI018424 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | +0.3 | 290 | 3.1 | SIN3A YY1 ZNF766 GLIS2 E2F8 ELK1 ZNF143 ATF7 KLF7 FOS | CDKL5 GC0XP018417 PIR56944 | |
GH0XI018501 | Promoter | 0.5 | EPDnew | 550.2 | +76.0 | 75968 | 0.1 | CDKL5 GJA6P PIR56944 | ||
GH0XI018674 | Promoter/Enhancer | 1.8 | FANTOM5 Ensembl ENCODE | 1.7 | +249.5 | 249463 | 1.7 | ATF1 SIN3A BRCA1 NCOA2 GTF3C2 GLIS2 ZNF213 ELK1 ZNF207 ZNF143 | PPEF1 TRV-TAC1-2 CDKL5 PHKA2 | |
GH0XI018421 | Enhancer | 0.6 | ENCODE | 0.8 | -3.1 | -3127 | 1.1 | ATF1 JUN JUNB BRCA1 ATF2 SP1 JUND CREB1 ATF7 FOS | CDKL5 GC0XP018417 | |
GH0XI018616 | Enhancer | 0.8 | Ensembl ENCODE | 0.1 | +191.9 | 191892 | 1.4 | SOX5 SOX13 NFIA HLF SIN3A TEAD3 TGIF2 SP1 JUND HNF1A | PIR35788 GC0XP018534 CDKL5 |
Regulatory Element Products
Genomic Locations for CDKL5 Gene
- chrX:18,425,583-18,660,858
- (GRCh38/hg38)
- Size:
- 235,276 bases
- Orientation:
- Plus strand
- chrX:18,443,703-18,671,749
- (GRCh37/hg19)
Genomic View for CDKL5 Gene
- Cytogenetic band:
-
- Xp22.13 by Ensembl
- Xp22.13 by Entrez Gene
- Xp22.13 by HGNC


RefSeq DNA sequence for CDKL5 Gene
Proteins for CDKL5 Gene
-
Protein details for CDKL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O76039-CDKL5_HUMAN
- Recommended name:
- Cyclin-dependent kinase-like 5
- Protein Accession:
- O76039
- G9B9X4
- Q14198
- Q5H985
- Q8IYC7
- Q9UJL6
Protein attributes for CDKL5 Gene
- Size:
- 1030 amino acids
- Molecular mass:
- 115538 Da
- Quaternary structure:
-
- Interacts with MECP2.
- SequenceCaution:
-
- Sequence=CAA61445.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};
Protein Expression for CDKL5 Gene
Selected DME Specific Peptides for CDKL5 Gene
- O76039:
-
- YVATRWYR
- SEIDQLF
- PYGKSVD
- WSVGCIL
- HRDIKPEN
- KLYLVFE
Post-translational modifications for CDKL5 Gene
- Autophosphorylated.
Other Protein References for CDKL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for CDKL5
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-
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Protein Products
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-
Abcam proteins for CDKL5
Assay Products
Domains & Families for CDKL5 Gene
Gene Families for CDKL5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for CDKL5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDKL5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O76039UniProtKB/Swiss-Prot:
CDKL5_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDKL5 Gene
Molecular function for CDKL5 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Mediates phosphorylation of MECP2.
Enzyme Numbers (IUBMB) for CDKL5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IDA | 16935860 |
GO:0004674 | protein serine/threonine kinase activity | TAS | 9721213 |
GO:0004693 | NOT cyclin-dependent protein serine/threonine kinase activity | IBA | -- |
GO:0005524 | ATP binding | IDA | 16935860 |
GO:0016301 | kinase activity | IDA | 15917271 |
Phenotypes for CDKL5 Gene
- MGI mutant phenotypes for CDKL5:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CDKL5:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Effect on mitosis
- Decreased viability
- Increased transcriptional activity
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell death HMECs cells
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased substrate adherent cell growth
- Increased cell migration
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Increased G1 length, increased G2 length
- Synthetic lethal with gemcitabine
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for CDKL5 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CDKL5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
- Search ViGene Biosciences for CDKL5
CRISPR Products
-
OriGene CRISPR knockouts for CDKL5
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- Overview of 69 available CDKL5 gene related products
- Applied Biological Materials CRISPR for CDKL5
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for CDKL5 Gene
- miRTarBase miRNAs that target CDKL5
miRNA Products
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Inhibitory RNA Products
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- Overview of 69 available CDKL5 gene related products
-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CDKL5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for CDKL5
-
ViGene Biosciences adenoviral particle packaged cDNA for CDKL5 gene
-
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-
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No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for CDKL5 Gene
Localization for CDKL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDKL5 Gene
- Nucleus.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 16935860 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0032587 | colocalizes_with ruffle membrane | ISS | -- |
GO:0032839 | dendrite cytoplasm | IBA,ISS | -- |
Pathways & Interactions for CDKL5 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sweet Taste Signaling |
.37
|
|
2 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
Pathways by source for CDKL5 Gene
1 GeneTex pathway for CDKL5 Gene
1 BioSystems pathway for CDKL5 Gene
1 Qiagen pathway for CDKL5 Gene
Interacting Proteins for CDKL5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001764 | neuron migration | ISS | -- |
GO:0006468 | protein phosphorylation | TAS | 9721213 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0043547 | positive regulation of GTPase activity | ISS | -- |
GO:0045773 | positive regulation of axon extension | ISS,IBA | -- |
Drugs & Compounds for CDKL5 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for CDKL5 Gene
mRNA/cDNA for CDKL5 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDKL5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDKL5
- genomics-online: gRNA clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
- Applied Biological Materials CRISPR for CDKL5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDKL5
- GenScript: Design CRISPR guide RNA sequences for CDKL5
miRNA Products
- Search ViGene Biosciences for CDKL5
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDKL5
- Browse OriGene Inhibitory RNA Products For CDKL5
- genomics-online: shRNA clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
Clone Products
- Sino Biological Human cDNA Clone for CDKL5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDKL5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDKL5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CDKL5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: |
Expression for CDKL5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDKL5 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDKL5 Gene:
CDKL5SOURCE GeneReport for Unigene cluster for CDKL5 Gene:
Hs.659851mRNA Expression by UniProt/SwissProt for CDKL5 Gene:
O76039-CDKL5_HUMANEvidence on tissue expression from TISSUES for CDKL5 Gene
- Nervous system(3.1)
- Lung(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKL5 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- brain
- cerebellum
- cranial nerve
- ear
- eye
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- salivary gland
- skull
- tongue
- tooth
- vocal cord
- chest wall
- diaphragm
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
- abdominal wall
- intestine
- large intestine
- stomach
- pelvis
- rectum
- arm
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
- blood vessel
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for CDKL5
- genomics-online: primer clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDKL5 Gene
Orthologs for CDKL5 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CDKL5 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | CDKL5 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CDKL5 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Cdkl5 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cdkl5 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CDKL5 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | CDKL5 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CDKL5 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | CDKL5 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | cdkl5 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.22826 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | cdkl5 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG6800 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | dyf-18 34 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KIN28 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for CDKL5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDKL5 Gene
Variants for CDKL5 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs104894928 | not-provided, pathogenic, not provided, Juvenile retinoschisis | 18,647,303(+) | C/G/T | genic_downstream_transcript_variant, intron_variant | |
rs104894929 | pathogenic, Juvenile retinoschisis | 18,642,012(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
rs104894930 | pathogenic, not-provided, Juvenile retinoschisis, not provided | 18,642,071(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs104894932 | pathogenic, not-provided, Juvenile retinoschisis, not provided | 18,647,301(+) | C/G/T | genic_downstream_transcript_variant, intron_variant | |
rs104894933 | pathogenic, not-provided, Juvenile retinoschisis, not provided | 18,647,296(+) | C/A | genic_downstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3359808 | CNV | insertion | 20981092 |
esv3573625 | CNV | loss | 25503493 |
esv3573626 | CNV | loss | 25503493 |
esv3576792 | CNV | gain | 25503493 |
nsv476338 | CNV | novel sequence insertion | 20440878 |
nsv528654 | CNV | gain | 19592680 |
nsv6821 | CNV | insertion | 18451855 |
Additional Variant Information for CDKL5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL5 Gene
Disorders for CDKL5 Gene

(23) MalaCards diseases for CDKL5 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
epileptic encephalopathy, early infantile, 2 |
|
|
rett syndrome |
|
|
cdkl5-related disorder |
|
|
autism |
|
|
focal epilepsy |
|
|
UniProtKB/Swiss-Prot
CDKL5_HUMAN- Epileptic encephalopathy, early infantile, 2 (EIEE2) [MIM:300672]: A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. However, EIEE2 and Rett syndrome are considered two distinct entities. {ECO:0000269 PubMed:12736870, ECO:0000269 PubMed:15492925, ECO:0000269 PubMed:15499549, ECO:0000269 PubMed:15689447, ECO:0000269 PubMed:15917271, ECO:0000269 PubMed:16015284, ECO:0000269 PubMed:16611748, ECO:0000269 PubMed:16935860, ECO:0000269 PubMed:17993579, ECO:0000269 PubMed:18790821, ECO:0000269 PubMed:18809835, ECO:0000269 PubMed:19241098, ECO:0000269 PubMed:19253388, ECO:0000269 PubMed:23662938, ECO:0000269 PubMed:23708187, ECO:0000269 PubMed:24564546, ECO:0000269 PubMed:26993267, ECO:0000269 PubMed:27864847}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).
Additional Disease Information for CDKL5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CDKL5 Gene
Publications for CDKL5 Gene
- Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation. (PMID: 16935860) Bertani I … Kilstrup-Nielsen C (The Journal of biological chemistry 2006) 2 3 4 22 58
- Xp22.3 genomic deletions involving the CDKL5 gene in girls with early onset epileptic encephalopathy. (PMID: 19780792) Mei D … Guerrini R (Epilepsia 2010) 3 22 44 58
- Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes. (PMID: 19241098) Russo S … Larizza L (Neurogenetics 2009) 3 4 22 58
- [Methyl-CpG-binding protein 2 gene and CDKL5 gene mutation in patients with Rett syndrome: analysis of 177 Chinese pediatric patients]. (PMID: 19552836) Li MR … Wu XR (Zhonghua yi xue za zhi 2009) 3 22 44 58
- Mutational spectrum of CDKL5 in early-onset encephalopathies: a study of a large collection of French patients and review of the literature. (PMID: 19793311) Nemos C … Philippe C (Clinical genetics 2009) 3 22 44 58
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CDKL5
- Novus Biologicals proteins and lysates for CDKL5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CDKL5
- Abcam proteins for CDKL5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CDKL5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDKL5
- VectorBuilder custom plasmid, inducible vectors for CDKL5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDKL5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 80 available CDKL5 Antibodies ranked by validation data
- Compare Top CDKL5 Antibodies
- antibodies-online: Search results for available CDKL5 related products ranked by validation data
- antibodies-online: Search results for 4 available CDKL5 Proteins ranked by validation data
- Compare Top CDKL5 Proteins
- GeneTex CDKL5 antibody for CDKL5
- Search GeneTex for Proteins for CDKL5
- ViGene Biosciences adenoviral particle packaged cDNA for CDKL5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDKL5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
- Search ViGene Biosciences for CDKL5
- Santa Cruz Biotechnology (SCBT) Antibodies for CDKL5
- Search Santa Cruz Biotechnology (SCBT) for CDKL5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDKL5
- Horizon Cell Lines for CDKL5
- genomics-online: cdna clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
- orf clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
- genomics-online: gRNA clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
- genomics-online: primer clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
- genomics-online: shRNA clones - Search results for 69 available CDKL5 gene related products
- Overview of 69 available CDKL5 gene related products
Sources for CDKL5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew