Aliases for CDKL5 Gene
Aliases for CDKL5 Gene
External Ids for CDKL5 Gene
- HGNC: 11411
- Entrez Gene: 6792
- Ensembl: ENSG00000008086
- OMIM: 300203
- UniProtKB: O76039
Previous HGNC Symbols for CDKL5 Gene
- STK9
Previous GeneCards Identifiers for CDKL5 Gene
- GC0XP017109
- GC0XP017645
- GC0XP017805
- GC0XP018203
- GC0XP018353
- GC0XP016199
Summaries for CDKL5 Gene
-
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDKL5 Gene
CDKL5 (Cyclin Dependent Kinase Like 5) is a Protein Coding gene. Diseases associated with CDKL5 include Epileptic Encephalopathy, Early Infantile, 2 and Rett Syndrome. Among its related pathways are BDNF signaling pathway and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3.
UniProtKB/Swiss-Prot for CDKL5 Gene
-
Mediates phosphorylation of MECP2.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL5 Gene
Genomics for CDKL5 Gene
Regulatory Elements for CDKL5 Gene
Enhancers for CDKL5 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CDKL5 on UCSC Golden Path with GeneCards custom track
Promoters for CDKL5 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CDKL5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CDKL5 gene promoter:
Regulatory Element Products
Genomic Location for CDKL5 Gene
- Chromosome:
- X
- Start:
- 18,425,583 bp from pter
- End:
- 18,660,858 bp from pter
- Size:
- 235,276 bases
- Orientation:
- Plus strand
Genomic View for CDKL5 Gene
Genes around CDKL5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.13 by Ensembl
- Xp22 by Entrez Gene
- Xp22 by HGNC
CDKL5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDKL5 Gene
Proteins for CDKL5 Gene
-
Protein details for CDKL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O76039-CDKL5_HUMAN
- Recommended name:
- Cyclin-dependent kinase-like 5
- Protein Accession:
- O76039
- G9B9X4
- Q14198
- Q5H985
- Q8IYC7
- Q9UJL6
Protein attributes for CDKL5 Gene
- Size:
- 1030 amino acids
- Molecular mass:
- 115538 Da
- Quaternary structure:
-
- Interacts with MECP2.
- SequenceCaution:
-
- Sequence=CAA61445.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};
Protein Expression for CDKL5 Gene
Selected DME Specific Peptides for CDKL5 Gene
Post-translational modifications for CDKL5 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CDKL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CDKL5
- Novus Biologicals Antibodies for CDKL5
- Invitrogen Antibodies for CDKL5
- antibodies-online Antibodies for CDKL5: See all 76
- GeneTex CDKL5 antibody for CDKL5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDKL5
Protein Products
-
OriGene Purified Proteins for CDKL5
- Search Origene for MassSpec and Protein Over-expression Lysates for CDKL5
- Origene Custom Protein Services for CDKL5
- Search GeneTex for Proteins for CDKL5
Assay Products
Domains & Families for CDKL5 Gene
Gene Families for CDKL5 Gene
- HGNC:
- IUPHAR :
Protein Domains for CDKL5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDKL5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O76039UniProtKB/Swiss-Prot:
CDKL5_HUMAN :- Contains 1 protein kinase domain.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Domain:
-
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDKL5 Gene
Molecular function for CDKL5 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Mediates phosphorylation of MECP2.
Enzyme Numbers (IUBMB) for CDKL5 Gene
- EC 2.7.11 63
- EC 2.7.11.22 63 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | TAS | 9721213 |
Phenotypes for CDKL5 Gene
- MGI mutant phenotypes for CDKL5:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CDKL5:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Effect on mitosis
- Decreased viability
- Increased transcriptional activity
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell death HMECs cells
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased substrate adherent cell growth
- Increased cell migration
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Increased G1 length, increased G2 length
- Synthetic lethal with gemcitabine
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for CDKL5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CDKL5
-
ViGene Biosciences lentiviral particle packaged cDNA for CDKL5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
- Search ViGene Biosciences for CDKL5
CRISPR Products
-
OriGene CRISPR knockouts for CDKL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDKL5
- GenScript: Design CRISPR guide RNA sequences for CDKL5
miRNA for CDKL5 Gene
- miRTarBase miRNAs that target CDKL5
miRNA Products
- Search ViGene Biosciences for CDKL5
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CDKL5
- Browse OriGene Inhibitory RNA Products For CDKL5
-
ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
Clone Products
- OriGene clones in human for CDKL5
- OriGene ORF clones in human,mouse for CDKL5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CDKL5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CDKL5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDKL5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for CDKL5 Gene
Localization for CDKL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDKL5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032839 | dendrite cytoplasm | ISS | -- |
Pathways & Interactions for CDKL5 Gene
More details on SuperPathways for CDKL5| Superpath | Contained pathways | |
|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
| 2 | BDNF signaling pathway |
Pathways by source for CDKL5 Gene
1 GeneTex pathway for CDKL5 Gene
1 BioSystems pathway for CDKL5 Gene
1 Qiagen pathway for CDKL5 Gene
Interacting Proteins for CDKL5 Gene
Selected Interacting proteins:
O76039-CDKL5_HUMAN
ENSP00000369325
for CDKL5 Gene via
MINT
STRING
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001764 | neuron migration | ISS | -- |
| GO:0006468 | protein phosphorylation | IEA,TAS | 9721213 |
| GO:0046777 | protein autophosphorylation | IDA | 16935860 |
| GO:0051726 | regulation of cell cycle | IEA | -- |
Drugs & Compounds for CDKL5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for CDKL5 Gene
mRNA/cDNA for CDKL5 Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDKL5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDKL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDKL5
- GenScript: Design CRISPR guide RNA sequences for CDKL5
miRNA Products
- Search ViGene Biosciences for CDKL5
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CDKL5
- Browse OriGene Inhibitory RNA Products For CDKL5
-
ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
Clone Products
- OriGene clones in human for CDKL5
- OriGene ORF clones in human,mouse for CDKL5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CDKL5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: |
Expression for CDKL5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in Nasal epithelium (55.5) and Plasma (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDKL5 Gene
SOURCE GeneReport for Unigene cluster for CDKL5 Gene Hs.659851
mRNA Expression by UniProt/SwissProt for CDKL5 Gene
O76039-CDKL5_HUMAN
Tissue specificity:
Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.
Primer Products
-
OriGene qPCR primer pairs for CDKL5
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDKL5 Gene
Orthologs for CDKL5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CDKL5 35 |
|
||
| CDKL5 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CDKL5 35 |
|
||
| CDKL5 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Cdkl5 35 |
|
||
| Cdkl5 16 |
|
||||
| Cdkl5 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CDKL5 35 |
|
||
| CDKL5 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cdkl5 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDKL5 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDKL5 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CDKL5 35 |
|
||
| CDKL5 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | CDKL5 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdkl5 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.22826 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cdkl5 35 |
|
||
| cdkl5 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6800 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | dyf-18 36 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KIN28 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for CDKL5:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDKL5 Gene
(17) SIMAP similar genes for CDKL5 Gene using alignment to 1 proteins:
Variants for CDKL5 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_023560 | Epileptic encephalopathy, early infantile, 2 (EIEE2) | ||||
| VAR_023561 | Epileptic encephalopathy, early infantile, 2 (EIEE2) | ||||
| rs35478150 | - | 18,619,962(+) | ATCTC(A/C)AACAG | nc-transcript-variant, reference, missense | |
| VAR_036578 | A colorectal cancer sample | ||||
| VAR_037635 | Epileptic encephalopathy, early infantile, 2 (EIEE2) |
Residual Variation Intolerance Score:
2.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.59;
44.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CDKL5 Gene
- Human Gene Mutation Database (HGMD)
- CDKL5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL5 Gene
Disorders for CDKL5 Gene
(17) MalaCards diseases for CDKL5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epileptic encephalopathy, early infantile, 2 |
|
|
| rett syndrome |
|
|
| autistic disorder |
|
|
| west syndrome |
|
|
| angelman syndrome |
|
|
Search CDKL5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CDKL5_HUMAN- Epileptic encephalopathy, early infantile, 2 (EIEE2) [MIM:300672]: A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. However, EIEE2 and Rett syndrome are considered two distinct entities. {ECO:0000269 PubMed:12736870, ECO:0000269 PubMed:15492925, ECO:0000269 PubMed:15499549, ECO:0000269 PubMed:15689447, ECO:0000269 PubMed:15917271, ECO:0000269 PubMed:16015284, ECO:0000269 PubMed:16611748, ECO:0000269 PubMed:17993579, ECO:0000269 PubMed:18790821, ECO:0000269 PubMed:18809835, ECO:0000269 PubMed:19241098, ECO:0000269 PubMed:19253388, ECO:0000269 PubMed:24564546}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).
Relevant External Links for CDKL5
No data available for Genatlas for CDKL5 Gene
Publications for CDKL5 Gene
- Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation. (PMID: 16935860) Bertani I. … Kilstrup-Nielsen C. (J. Biol. Chem. 2006) 2 3 4 23 67
- A novel p.Arg970X mutation in the last exon of the CDKL5 gene resulting in late-onset seizure disorder. (PMID: 19428276) Psoni S. … Kitsiou-Tzeli S. (Eur. J. Paediatr. Neurol. 2010) 3 23
- Xp22.3 genomic deletions involving the CDKL5 gene in girls with early onset epileptic encephalopathy. (PMID: 19780792) Mei D. … Guerrini R. (Epilepsia 2010) 3 23
- Cyclin-dependent kinase-like 5 (CDKL5) mutation screening in Rett syndrome and related disorders. (PMID: 20397747) White R. … Christodoulou J. (Twin Res Hum Genet 2010) 3 23
- Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. (PMID: 20513142) Zweier M. … Rauch A. (Hum. Mutat. 2010) 3 23
Products for CDKL5 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for CDKL5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDKL5
- Search Origene for MassSpec and Protein Over-expression Lysates for CDKL5
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- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CDKL5
- Browse OriGene Inhibitory RNA Products For CDKL5
- OriGene qPCR primer pairs for CDKL5
- OriGene CRISPR knockouts for CDKL5
- OriGene clones in human for CDKL5
- OriGene ORF clones in human,mouse for CDKL5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CDKL5
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- GenScript: Design CRISPR guide RNA sequences for CDKL5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDKL5
- Novus Biologicals Antibodies for CDKL5
- Novus Biologicals proteins and lysates for CDKL5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CDKL5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for CDKL5 gene
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- ViGene Biosciences lentiviral particle packaged cDNA for CDKL5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDKL5 gene
- Search ViGene Biosciences for CDKL5
- Search ViGene Biosciences for CDKL5
- Santa Cruz Biotechnology (SCBT) Antibodies for CDKL5
- Search Santa Cruz Biotechnology (SCBT) for CDKL5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDKL5
Sources for CDKL5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
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