CDKL5 Gene
protein-coding GIFtS: 61
GCID: GC0XP018443
|
|
cyclin-dependent kinase-like 5(Previous name: serine/threonine kinase 9 )
(Previous symbol: STK9)
| |
Aliases
for CDKL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin-Dependent Kinase-Like 51 2 | | EC 2.7.11.223 8 | | STK91 2 3 5 | | ISSX2 5 | | EIEE21 2 5 | | Cyclin Dependent Kinase 5 Transcript2 | | Serine/Threonine Kinase 91 2 | | EC 2.7.118 | | Serine/Threonine-Protein Kinase 92 3 | | |
Export aliases for CDKL5 gene to outside databasesPrevious GC identifers: GC0XP017109 GC0XP017645 GC0XP017805 GC0XP018203 GC0XP018353 GC0XP016199 |
Summaries
for CDKL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDKL5:
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinaseactivity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known asX-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039Function: Mediates phosphorylation of MECP2
Gene Wiki entry for CDKL5
|
Genomic Views
for CDKL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDKL5 gene promoter:
Sox5 HFH-1 Cart-1 FOXD3 Hlf FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDKL5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKL5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22 Ensembl cytogenetic band: Xp22.13 HGNC cytogenetic band: Xp22CDKL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP018443: view genomic region
(about GC identifiers)
Start:
|
18,443,703 bp from pter |
End:
|
18,671,749 bp from pter |
Size:
|
228,047 bases |
Orientation:
|
plus strand |
|
Proteins
for CDKL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039 (See
protein sequence)Recommended Name: Cyclin-dependent kinase-like 5 Size: 1030 amino acids; 115538 Da
Subunit: Interacts with MECP2
Subcellular location: Nucleus
Caution: It is uncertain whether Met-1 or Met-10 is the initiator
Sequence caution: Sequence=CAA61445.1; Type=Frameshift; Positions=415;
Secondary accessions: G9B9X4 Q14198 Q5H985 Q8IYC7 Q9UJL6Alternative splicing: 2 isoforms: O76039-1 O76039-2 (Predominant transcript in brain)Explore the universe of human proteins at neXtProt for CDKL5: NX_O76039
Post-translational modifications:
Autophosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O76039
4/6 DME Specific Peptides for CDKL5 (O76039) (see all 6)
CDKL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001032420.1 NP_003150.1
ENSEMBL proteins: ENSP00000369332 ENSP00000369325
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CDKL5 for ontologies About GeneDecksing
CDKL5 Antibody Products:
Assay Products for CDKL5: |
Protein
Domains /
Families
for CDKL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDKL5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O76039ProtoNet protein and cluster: O76039 UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CDKL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039Function: Mediates phosphorylation of MECP2Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL5 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CDKL5 (NM_003159) | |  | Sino Biological Human cDNA Clone for CDKL5 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDKL5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL5 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CDKL5 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for CDKL5:
|
Pathways & Interactions
for CDKL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDKL5
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDKL5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/8 Interacting proteins for CDKL5 (O760392, 3 ENSP000003693254) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
CDKL5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDKL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDKL5
2 HMDB Compounds for CDKL5 About this table
Search CenterWatch for drugs/clinical trials and news about CDKL5
|
Transcripts
for CDKL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDKL5 gene (2 alternative transcripts): NM_001037343.1 NM_003159.2 Unigene Cluster for CDKL5: Cyclin-dependent kinase-like 5 Hs.659851 [show with all ESTs]Unigene Representative Sequence: BC0360913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379996(uc022btn.1 uc004cym.3) ENST00000379989(uc004cyn.3)
ENST00000463994
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL5 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CDKL5 (NM_003159) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK056879.1 AK307444.1 AY217744.1 BC010966.1 BC036091.1 HQ171445.1 X89059.1 Y15057.1 4 DOTS entries: DT.409032 DT.97771331 DT.95234867 DT.75136827 22 AceView cDNA sequences: AI569744 Y15057 AY217744 AA398911 BC010966 CD675032 NM_003159 X89059 AK056879 BC036091 BE831003 CB153498 BI559845 AI582736 W07775 BX096833 AL704691 AA403214 N80713 AI286150 BF679133 AA228740
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CDKL5 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDKL5
|
Expression
for CDKL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDKL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGAACCAA
About this image
See CDKL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDKL5
SOURCE GeneReport for Unigene cluster: Hs.659851
UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039Tissue specificity: Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis
SABiosciences Custom PCR Arrays for CDKL5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDKL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CDKL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKL5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL5 |
Orthologs
for CDKL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CDKL5 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDKL51 |
cyclin-dependent kinase-like 5 |
79.68(n)
83.54(a) |
|
428001 XM_425571.2 XP_425571.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CDKL56 |
-- |
79(a) |
1 ↔ 1 |
3(122952872-123000723) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.228262 |
Xenopus laevis transcribed sequence with strong similarity more |
84.46(n) |
|
BJ059534.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cdkl51 |
cyclin-dependent kinase-like 5 |
65.23(n)
66.36(a) |
|
559341 NM_001130771.1 NP_001124243.1 |
ENSEMBL Gene Tree for CDKL5 (if available)
TreeFam Gene Tree for CDKL5 (if available) |
Paralogs
for CDKL5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDKL5 gene
- CDKL12 CDKL22 MOK2 CDKL32 MAK2 CDKL42 ICK2
17 SIMAP similar genes for CDKL5 using alignment to 1 protein entry: CDKL5_HUMAN:CDK2 CDK3 CDK7 CDKL2 PCTK1 MAPK1
CDK6 CDK4 CDK10 GSK3B MAPK12 MAPK14
MAPK11 MAPK13 CDK9 MAPK8 MOK
CDKL5 for paralogs About GeneDecksing
|
Genomic Variants
for CDKL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDKL5 (18443703 - 18671749 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CDKL5
4 Indels: 96514 83382 83381 83380
Human Gene Mutation Database (HGMD): CDKL5
Locus Specific Mutation Databases (LSDB): CDKL5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKL5 |
|
Disorders
/ Diseases
for CDKL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDKL5 for disorders About GeneDecksing
OMIM gene information: 300203
OMIM disorders: 300672 105830
UniProtKB/Swiss-Prot: CDKL5_HUMAN, O76039
Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spamsand psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15) Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 (EIEE2) [MIM:300672]; alsoknown as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasmsbeginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speechdevelopment, stereotypic hand movements
17  diseases for CDKL5: About MalaCardsepileptic encephalopathy, early infantile, 2 west syndrome rett syndrome angelman syndrome-like
precocious puberty intractable epilepsy angelman syndrome aicardi syndrome
intellectual disability seizures was-related disorders seizure disorder
microcephaly brain disease cataract prostatitis
neuronitis
6 diseases from the University of Copenhagen DISEASES database for CDKL5:Rett syndrome Intellectual disability Aicardi syndrome Microcephaly
Gait apraxia Brain disease 8 Novoseek disease relationships for CDKL5 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rett syndrome |
94.3 |
46 |
19740913 (2), 18701457 (2), 16813600 (2), 19241098 (2) (see all 26) |
| infantile spasms |
91.6 |
43 |
16806828 (2), 15689447 (2), 17049193 (2), 16935860 (2) (see all 21) |
| cryptogenic west syndrome |
85.5 |
1 |
16806828 (1) |
| severe mental retardation |
68.7 |
3 |
20513142 (1), 12736870 (1), 16015284 (1) |
| mental retardation |
68.5 |
12 |
16935860 (2), 15492925 (2), 20397747 (1), 15499549 (1) (see all 7) |
| encephalopathy |
67.7 |
19 |
17256798 (2), 17993579 (2), 19780792 (2), 19740913 (1) (see all 11) |
| epilepsy |
65.3 |
34 |
18266744 (5), 19780792 (3), 19428276 (2), 16326141 (2) (see all 14) |
| myoclonic seizure |
63.2 |
2 |
16326141 (1), 17049193 (1) |
Human Genome Epidemiology (HuGE) Navigator: CDKL5 (11 documents)
Export disorders for CDKL5 gene to outside databases
|
Publications
for CDKL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDKL5 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with CDKL5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation. (PubMed id 16935860)1, 2, 3, 9 Bertani I.... Kilstrup-Nielsen C. (2006)
- Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region. (PubMed id 9721213)1, 2, 3 Montini E.... Franco B. (1998)
- CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome. (PubMed id 15917271)1, 2, 9 Mari F.... Landsberger N. (2005)
- Key clinical features to identify girls with CDKL5 mutations. (PubMed id 18790821)1, 2, 9 Bahi-Buisson N.... Bienvenu T. (2008)
- Impairment of CDKL5 nuclear localisation as a cause for severe infantile encephalopathy. (PubMed id 17993579)1, 2, 9 Rosas-Vargas H.... Bienvenu T. (2008)
- Early onset seizures and Rett-like features associated with mutations in CDKL5. (PubMed id 16015284)1, 2, 9 Evans J.C.... Clarke A.J. (2005)
- Mutations of CDKL5 cause a severe neurodevelopmental disorder with infantile spasms and mental retardation. (PubMed id 15492925)1, 2, 9 Weaving L.S.... Gecz J. (2004)
- Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes. (PubMed id 19241098)1, 2, 9 Russo S.... Larizza L. (2009)
- CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms. (PubMed id 15689447)1, 2, 9 Scala E....Renieri A. (2005)
- Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. (PubMed id 15499549)1, 2, 9 Tao J.... Kalscheuer V.M. (2004)
|
External Searches for CDKL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDKL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDKL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDKL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDKL5 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CDKL5 |
|
| | |
About This Section
| Patent Information for CDKL5 gene:
Search GeneIP for patents involving CDKL5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDKL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDKL5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKL5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDKL5 | | | OriGene Protein Over-expression Lysate for CDKL5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDKL5 | | OriGene 3'-UTR Clone for CDKL5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDKL5 | | OriGene Custom Protein Services for CDKL5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDKL5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKL5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKL5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKL5 |
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| | | | Search Tocris compounds for CDKL5 |
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 | | | CDKL5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL5 |
|  |  |  | | | | ThermoFisher Antibodies for CDKL5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL5 |
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