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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDKL4 Gene

protein-coding   GIFtS: 46
GCID: GC02M039402

Cyclin-Dependent Kinase-Like 4

  Search for CDKL4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase-Like 41 2
EC 2.7.11.223 8
EC 2.7.118

External Ids:    HGNC: 192871   Entrez Gene: 3443872   Ensembl: ENSG000002051117   UniProtKB: Q5MAI53   

Export aliases for CDKL4 gene to outside databases

Previous GC identifers: GC02M039381 GC02M039317 GC02M039260 GC02M039145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDKL4 Gene: 
CDKL4 (cyclin-dependent kinase-like 4) is a protein-coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDKL1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKL4 gene promoter:
         HFH-3   STAT1   HSF1 (long)   FOXD3   FOXI1   RORalpha1   Nkx6-1   IRF-7A   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDKL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

CDKL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKL4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M039402:  view genomic region     (about GC identifiers)

Start:
39,402,787 bp from pter      End:
39,456,729 bp from pter
Size:
53,943 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDKL4_HUMAN, Q5MAI5 (See protein sequence)
Recommended Name: Cyclin-dependent kinase-like 4  
Size: 315 amino acids; 36223 Da
Subcellular location: Cytoplasm (Probable)

Explore the universe of human proteins at neXtProt for CDKL4: NX_Q5MAI5

Explore proteomics data for CDKL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5MAI5

  • 4/5 DME Specific Peptides for CDKL4 (Q5MAI5) (see all 5)
     YVATRWYR  HRDIKPEN  TRWYRAPE  NLVNLIEVFR 

    CDKL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDKL4 Protein Expression
    REFSEQ proteins: NP_001009565.1  
    ENSEMBL proteins: 
     ENSP00000389833   ENSP00000368080   ENSP00000378476   ENSP00000399213  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    CDKL4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase-like 4 
    Cyclin-dependent kinase-like (CDKL) family

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q5MAI5

    ProtoNet protein and cluster: Q5MAI5

    UniProtKB/Swiss-Prot: CDKL4_HUMAN, Q5MAI5
    Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDKL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDKL4_HUMAN, Q5MAI5
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    CDKL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDKL4:
     Decreased Salmonella enterica  

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDKL4

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    CDKL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDKL4

    2 HMDB Compounds for CDKL4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDKL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDKL4 gene: 
    NM_001009565.1  

    Unigene Cluster for CDKL4:

    Cyclin-dependent kinase-like 4
    Hs.403201  [show with all ESTs]
    Unigene Representative Sequence: AY845084
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451199 ENST00000378803(uc002rrm.3) ENST00000395035(uc010fal.2)
    ENST00000419111
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKL4:
    hsa-miR-499-3p hsa-miR-488 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDKL4 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKL4

    Additional mRNA sequence: 

    AY845084.1 AY847283.1 BC144460.1 

    3 DOTS entries:

    DT.120967238  DT.99977524  DT.40300918 

    2 AceView cDNA sequences:

    AA626859 BU686325 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDKL4 expression in normal human tissues (normalized intensities)      CDKL4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGGTGTC
    CDKL4 Expression
    About this image


    CDKL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate

    See CDKL4 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.403201
        SABiosciences Custom PCR Arrays for CDKL4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDKL4 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkl41 , 5 cyclin-dependent kinase-like 41, 5 83.07(n)1
    90.73(a)1
      17 (50.90 cM)5
    3811131  NM_001033443.41  NP_001028615.11 
     805235505 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGV16
    Cyclin (Bur2p)-dependent protein kinase that funct...
    15(a)
    1 → many
    XVI(864449-866422)


    ENSEMBL Gene Tree for CDKL4 (if available)
    TreeFam Gene Tree for CDKL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDKL4 gene
    CDKL12  CDKL22  CDKL52  CDKL32  
    18/61 SIMAP similar genes for CDKL4 using alignment to 5 protein entries:     CDKL4_HUMAN (see all proteins) (see all similar genes):
    CDKL1    CDKL2    CDKL3    CDC2    CDK2    CDK1
    CDK16    CDK3    MAP4K1    MAPK7    CDK18    DKFZp686L20222
    CDK7    CDK17    CDK15    PCTK1    STK3    STK4

    CDKL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1237 SNPs in CDKL4 are shown (see all 1237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157082811,2
    C,F--39405238(+) GCTGCA/GTTGGG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1444285751,2
    --39405363(+) TTTGAC/TTTTTC 1 -- ds50010--------
    rs1466305901,2
    C--39405404(+) AAAGGC/TTGGGA 1 -- ds50010--------
    rs67109891,2
    C,F,H--39405457(+) AAGACA/GAATGA 1 -- ds500129Minor allele frequency- G:0.10NA NS EA WA CSA 2032
    rs1401884441,2
    --39405469(+) TGAAAA/GTTAGA 1 -- ds50010--------
    rs176659981,2
    C,F,H--39405570(+) TGTTCG/ATCTAC 1 -- ds500122Minor allele frequency- A:0.11NA NS EA 2542
    rs1813536911,2
    --39405663(+) TGAACC/GAAAAC 1 -- ds50010--------
    rs2009540521,2
    C,F--39405784(+) CTGTTC/TTGCAA 1 -- ut311Minor allele frequency- T:0.00EU 593
    rs1868330551,2
    C--39405840(+) ATTCCG/TTTGTA 1 -- ut310--------
    rs1450835761,2
    C--39405863(+) GGTTT-/ATGAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDKL4 (39402787 - 39456729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDKL4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677029CNV Deletion23128226
    esv1085195CNV Deletion17803354
    esv2719953CNV Deletion23290073
    esv2666347CNV Deletion23128226
    nsv873885CNV Loss21882294
    nsv833847CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDKL4 for disorders           About MalaCards

    CDKL4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDKL4
    Human Genome Epidemiology (HuGE) Navigator: CDKL4 (1 document)

    Export disorders for CDKL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDKL4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CDKL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes. (PubMed id 19241098)1, 4 Russo S.... Larizza L. (2009)
    2. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 344387 HGNC: 19287 AceView: CDKL4 Ensembl:ENSG00000205111 euGenes: HUgn344387
    ECgene: CDKL4 H-InvDB: CDKL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDKL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDKL4 gene:
    Search GeneIP for patents involving CDKL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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