CDKL4 Gene
protein-coding GIFtS: 41
GCID: GC02M039402
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|
cyclin-dependent kinase-like 4
| |
Aliases
for CDKL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin-Dependent Kinase-Like 41 2 | | EC 2.7.11.223 8 | | EC 2.7.118 |
Export aliases for CDKL4 gene to outside databasesPrevious GC identifers: GC02M039381 GC02M039317 GC02M039260 GC02M039145 |
Summaries
for CDKL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CDKL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDKL4 gene promoter:
HFH-3 STAT1 HSF1 (long) FOXD3 FOXI1 RORalpha1 Nkx6-1 IRF-7A HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDKL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22.1 Ensembl cytogenetic band: 2p22.1 HGNC cytogenetic band: 2p22.3CDKL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M039402: view genomic region
(about GC identifiers)
Start:
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39,402,787 bp from pter |
End:
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39,456,729 bp from pter |
Size:
|
53,943 bases |
Orientation:
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minus strand |
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Proteins
for CDKL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDKL4_HUMAN, Q5MAI5 (See
protein sequence)Recommended Name: Cyclin-dependent kinase-like 4 Size: 315 amino acids; 36223 Da
Subcellular location: Cytoplasm (Probable)Explore the universe of human proteins at neXtProt for CDKL4: NX_Q5MAI5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5MAI5
4/5 DME Specific Peptides for CDKL4 (Q5MAI5) (see all 5)
CDKL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009565.1
ENSEMBL proteins: ENSP00000389833 ENSP00000368080 ENSP00000378476 ENSP00000399213
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CDKL4 for ontologies About GeneDecksing
CDKL4 Antibody Products:
Assay Products for CDKL4: |
Protein
Domains /
Families
for CDKL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDKL4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5MAI5ProtoNet protein and cluster: Q5MAI5 UniProtKB/Swiss-Prot: CDKL4_HUMAN, Q5MAI5Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding regionSimilarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CDKL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDKL4_HUMAN, Q5MAI5Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0004693 | cyclin-dependent protein kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
CDKL4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CDKL4:
|
Pathways & Interactions
for CDKL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDKL4
|
Drugs & Compounds
for CDKL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDKL4
2 HMDB Compounds for CDKL4 About this table
Search CenterWatch for drugs/clinical trials and news about CDKL4
|
Transcripts
for CDKL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDKL4 gene: NM_001009565.1 Unigene Cluster for CDKL4: Cyclin-dependent kinase-like 4 Hs.403201 [show with all ESTs]Unigene Representative Sequence: AY8450844 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000451199 ENST00000378803(uc002rrm.3) ENST00000395035(uc010fal.2)
ENST00000419111
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDKL4 (NM_001009565) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDKL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL4 |
Additional cDNA sequence: AY845084.1 AY847283.1 BC144460.1 3 DOTS entries: DT.120967238 DT.99977524 DT.40300918 2 AceView cDNA sequences: AA626859 BU686325
GeneLoc Exon Structure
|
Expression
for CDKL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDKL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGGTGTC
About this image
See CDKL4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.403201
SABiosciences Custom PCR Arrays for CDKL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDKL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDKL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL4 |
Orthologs
for CDKL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDKL4 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDKL16 |
Uncharacterized protein |
62(a) |
possible ortholog |
5(60363150-60370817) |
lizard
(Anolis carolinensis) |
Reptilia |
CDKL16 |
-- |
62(a) |
possible ortholog |
GL343627.1(150040-162601) |
zebrafish
(Danio rerio) |
Actinopterygii |
cdkl16 |
cyclin-dependent kinase-like 1 (CDC2-related kinas... |
63(a) |
possible ortholog |
13(37095018-37105030) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG72366 |
-- |
36(a) |
1 ↔ 1 |
2L(5708449-5713648) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y42A5A.46 |
Protein Y42A5A.4, isoform a |
37(a) |
1 ↔ 1 |
V(11098871-11107258) |
ENSEMBL Gene Tree for CDKL4 (if available)
TreeFam Gene Tree for CDKL4 (if available) |
Paralogs
for CDKL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDKL4 gene
- CDKL12 CDKL22 CDKL52 MOK2 CDKL32 MAK2 ICK2
18/61 SIMAP similar genes for CDKL4 using alignment to 5 protein entries: CDKL4_HUMAN (see all proteins)
(see all similar genes):CDKL1 CDKL2 CDKL3 CDC2 CDK2 CDK3
CDK1 MAP4K1 CDK16 MAPK7 CDK18 DKFZp686L20222
CDK7 CDK17 CDK15 PCTK1 STK3 STK4
CDKL4 for paralogs About GeneDecksing
|
Genomic Variants
for CDKL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDKL4 (39402787 - 39456729 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDKL4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKL4 |
|
Disorders
/ Diseases
for CDKL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CDKL4 for disorders About MalaCards
CDKL4 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: CDKL4 (1 document)
Export disorders for CDKL4 gene to outside databases
|
Publications
for CDKL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDKL4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDKL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes. (PubMed id 19241098)1 Russo S.... Larizza L. (2009)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CDKL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDKL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDKL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDKL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDKL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDKL4 gene:
Search GeneIP for patents involving CDKL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDKL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDKL4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKL4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDKL4 | | | OriGene Protein Over-expression Lysate for CDKL4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDKL4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDKL4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDKL4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKL4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKL4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKL4 |
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 | | | CDKL4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL4 |
|  |  |  | | | | Search ThermoFisher Antibodies for CDKL4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL4 |
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