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Aliases for CDKL4 Gene

Aliases for CDKL4 Gene

  • Cyclin Dependent Kinase Like 4 2 3
  • Cyclin-Dependent Kinase-Like 4 2 5
  • EC 4 63
  • EC 2.7.11 63

External Ids for CDKL4 Gene

Previous GeneCards Identifiers for CDKL4 Gene

  • GC02M039381
  • GC02M039317
  • GC02M039260
  • GC02M039402
  • GC02M039145

Summaries for CDKL4 Gene

GeneCards Summary for CDKL4 Gene

CDKL4 (Cyclin Dependent Kinase Like 4) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL4 Gene

Genomics for CDKL4 Gene

Regulatory Elements for CDKL4 Gene

Enhancers for CDKL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDKL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDKL4 Gene

39,174,937 bp from pter
39,246,810 bp from pter
71,874 bases
Minus strand

Genomic View for CDKL4 Gene

Genes around CDKL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL4 Gene

Proteins for CDKL4 Gene

  • Protein details for CDKL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase-like 4
    Protein Accession:
    Secondary Accessions:
    • Q2NME9

    Protein attributes for CDKL4 Gene

    379 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDKL4 Gene


neXtProt entry for CDKL4 Gene

Proteomics data for CDKL4 Gene at MOPED

Selected DME Specific Peptides for CDKL4 Gene

Post-translational modifications for CDKL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKL4 Gene

Domains & Families for CDKL4 Gene

Gene Families for CDKL4 Gene

Protein Domains for CDKL4 Gene

Suggested Antigen Peptide Sequences for CDKL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL4: view

Function for CDKL4 Gene

Molecular function for CDKL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for CDKL4 Gene

Gene Ontology (GO) - Molecular Function for CDKL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDKL4: view
genes like me logo Genes that share phenotypes with CDKL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDKL4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKL4 Gene

Localization for CDKL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL4 Gene


Subcellular locations from

Jensen Localization Image for CDKL4 Gene COMPARTMENTS Subcellular localization image for CDKL4 gene
Compartment Confidence
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CDKL4 Gene

Pathways & Interactions for CDKL4 Gene

SuperPathways for CDKL4 Gene

No Data Available

Interacting Proteins for CDKL4 Gene

Gene Ontology (GO) - Biological Process for CDKL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDKL4: view

No data available for Pathways by source and SIGNOR curated interactions for CDKL4 Gene

Drugs & Compounds for CDKL4 Gene

(1) Drugs for CDKL4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDKL4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDKL4: view

Transcripts for CDKL4 Gene

mRNA/cDNA for CDKL4 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDKL4 Gene

Cyclin-dependent kinase-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL4 Gene

No ASD Table

Relevant External Links for CDKL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKL4 Gene

mRNA expression in normal human tissues for CDKL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDKL4 Gene

This gene is overexpressed in Testis (x14.1).

SOURCE GeneReport for Unigene cluster for CDKL4 Gene Hs.403201

genes like me logo Genes that share expression patterns with CDKL4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDKL4 Gene

Orthologs for CDKL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDKL4 35
  • 92.7 (n)
  • 94.29 (a)
CDKL4 36
  • 94 (a)
(Canis familiaris)
Mammalia CDKL4 35
  • 92.12 (n)
  • 93.29 (a)
CDKL4 36
  • 87 (a)
(Mus musculus)
Mammalia Cdkl4 35
  • 83.07 (n)
  • 90.73 (a)
Cdkl4 16
Cdkl4 36
  • 82 (a)
(Pan troglodytes)
Mammalia CDKL4 35
  • 98.4 (n)
  • 97.12 (a)
CDKL4 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Cdkl4 35
  • 83.08 (n)
  • 89.62 (a)
(Monodelphis domestica)
Mammalia CDKL4 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CDKL4 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7236 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y42A5A.4 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for CDKL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDKL4 Gene

Gene Tree for CDKL4 (if available)
Gene Tree for CDKL4 (if available)

Paralogs for CDKL4 Gene

Paralogs for CDKL4 Gene

genes like me logo Genes that share paralogs with CDKL4: view

Variants for CDKL4 Gene

Sequence variations from dbSNP and Humsavar for CDKL4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35947084 - 39,229,421(+) TTCAG(A/G)TTCCA reference, missense
rs35454041 - 39,229,375(+) ACATA(A/C/T)GTATT reference, missense
rs56353587 - 39,187,679(+) TTTTA(A/C)AGATT reference, synonymous-codon, missense
rs34819676 - 39,179,251(+) GAAAA(G/T)AATCA reference, missense
rs56330730 - 39,179,195(+) TTGGC(A/G)TCTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDKL4 Gene

Variant ID Type Subtype PubMed ID
nsv873885 CNV Loss 21882294
esv2666347 CNV Deletion 23128226
nsv833847 CNV Loss 17160897
esv2719953 CNV Deletion 23290073
esv1085195 CNV Deletion 17803354
esv2677029 CNV Deletion 23128226

Variation tolerance for CDKL4 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDKL4 Gene

Disorders for CDKL4 Gene

Relevant External Links for CDKL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDKL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDKL4 Gene

Publications for CDKL4 Gene

  1. Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes. (PMID: 19241098) Russo S. … Larizza L. (Neurogenetics 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDKL4 Gene

Sources for CDKL4 Gene