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CDKL3 Gene

protein-coding   GIFtS: 51
GCID: GC05M133541

Cyclin-Dependent Kinase-Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase-Like 31 2
NKIAMRE2 3 5
Serine-Threonine Protein Kinase NKIAMRE1 2
Serine/Threonine-Protein Kinase NKIAMRE2 3
EC 2.7.11.223 8
EC 2.7.118

External Ids:    HGNC: 154831   Entrez Gene: 512652   Ensembl: ENSG000000068377   OMIM: 6084595   UniProtKB: Q8IVW43   

Export aliases for CDKL3 gene to outside databases

Previous GC identifers: GC05M133292 GC05M134158 GC05M133664 GC05M133710 GC05M133662 GC05M128818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKL3 Gene:
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members
are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2,
and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in
leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CDKL3 Gene:
CDKL3 (cyclin-dependent kinase-like 3) is a protein-coding gene. Diseases associated with CDKL3 include chromosome 5q deletion, and mental retardation. GO annotations related to this gene include protein kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDKL3 gene promoter:
         COUP-TF1   GR   Sp1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   ARP-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDKL3 promoter sequence
   Search Chromatin IP Primers for CDKL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

CDKL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKL3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M133541:  view genomic region     (about GC identifiers)

Start:
133,541,305 bp from pter      End:
133,706,738 bp from pter
Size:
165,434 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDKL3_HUMAN, Q8IVW4 (See protein sequence)
Recommended Name: Cyclin-dependent kinase-like 3  
Size: 592 amino acids; 67514 Da
1 PDB 3D structure from and Proteopedia for CDKL3:
3ZDU (3D)    
Secondary accessions: D3DQA0 D3DQA1 Q9P114
Alternative splicing: 2 isoforms:  Q8IVW4-1   Q8IVW4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDKL3: NX_Q8IVW4

Explore proteomics data for CDKL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDKL3 (Q8IVW4) (see all 9)
     HENLVNL  FQILRAI  YVATRWYR  TGQIVAIK 


    See CDKL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107047.1  NP_057592.2  

    ENSEMBL proteins: 
     ENSP00000430777   ENSP00000427738   ENSP00000265334   ENSP00000427836   ENSP00000428500  
     ENSP00000428689   ENSP00000428498   ENSP00000430496   ENSP00000427964   ENSP00000477164  
     ENSP00000399807   ENSP00000441545   ENSP00000477366   ENSP00000395559  

    CDKL3 Human Recombinant Protein Products:

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    Novus Biologicals CDKL3 Lysate
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    Cloud-Clone Corp. Proteins for CDKL3

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    CDKL3 Assay Products:

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    Cloud-Clone Corp. CLIAs for CDKL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase-like 3
    Cyclin-dependent kinase-like (CDKL) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8IVW4

    ProtoNet protein and cluster: Q8IVW4

    UniProtKB/Swiss-Prot: CDKL3_HUMAN, Q8IVW4
    Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDKL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDKL3_HUMAN, Q8IVW4
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10463609
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    CDKL3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDKL3:
     Decreased substrate adherent c  Increased apoptosis  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Cdkl3 (no phenotypes)

    CDKL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKL3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKL3

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CDKL3:
    hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CDKL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDKL3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDKL3_HUMAN, Q8IVW4: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    golgi apparatus2
    nucleus2
    endosome1
    lysosome1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    CDKL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDKL3
    Interactions:

        Search GeneGlobe Interaction Network for CDKL3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CDKL3 (ENSP000002653344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GGA1ENSP000003413444STRING: ENSP00000341344
    SNRNP70ENSP000002214484STRING: ENSP00000221448
    TTF2ENSP000003584784STRING: ENSP00000358478
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10463609
    GO:0006468protein phosphorylation ----

    CDKL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKL3

    2 HMDB Compounds for CDKL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDKL3 gene (2 alternative transcripts): 
    NM_001113575.1  NM_016508.3  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520693 ENST00000519312 ENST00000265334(uc003kzf.4 uc011cxq.2)
    ENST00000518990 ENST00000523054 ENST00000521118 ENST00000520592 ENST00000523832
    ENST00000521755 ENST00000522501 ENST00000609654 ENST00000435240(uc011cxo.1)
    ENST00000536186(uc010jdw.2 uc011cxp.1) ENST00000609383 ENST00000435211(uc003kzg.4 uc011cxr.1)

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CDKL3:
    hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDKL3 (NM_016508)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CDKL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKL3
      QuantiTect SYBR Green Assays in human, mouse, rat CDKL3
      QuantiFast Probe-based Assays in human, mouse, rat CDKL3

    3 AceView cDNA sequences:

    AF087989 H99529 H99528 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDKL3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                              -                           
    SP2:                                -     -     -     -                                       
    SP3:                                                                                          
    SP4:                                                              -     -                     


    ECgene alternative splicing isoforms for CDKL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGAACTGA
    CDKL3 Expression
    About this image

    CDKL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKL3 Protein Expression
        Custom PCR Arrays for CDKL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDKL3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkl31 , 5 cyclin-dependent kinase-like 31, 5 83.14(n)1
    81.05(a)1
      11 (31.85 cM)5
    2130841  NM_153785.41  NP_722480.31 
     520042215 
    lizard
    (Anolis carolinensis)
    Reptilia CDKL36
    cyclin-dependent kinase-like 3
    67(a)
    1 ↔ 1
    2(130899452-130922659)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72366
    --
    29(a)
    1 → many
    2L(5708449-5713648)
    worm
    (Caenorhabditis elegans)
    Secernentea Y42A5A.46
    Protein Y42A5A.4, isoform b
    30(a)
    1 → many
    V(11098950-11107276) WBGene00012779


    ENSEMBL Gene Tree for CDKL3 (if available)
    TreeFam Gene Tree for CDKL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKL3 gene
    CDKL12  CDK202  CDKL22  CDKL52  CDK72  CDKL42  
    Selected SIMAP similar genes for CDKL3 using alignment to 12 protein entries:     CDKL3_HUMAN (see all proteins) (see all similar genes):
    PPP2CA    PPP2CB    PPP4C    CDKL4    PPP6C    CDC2
    CDKL2    MAP4K4    CDK18    CCRK    MAPK7    CDKL1
    CAMK1    CDK3    CDK7    MAK    NEK6    TSSK4

    CDKL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKL3 (see all 1190)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873563811,2
    --133633629(+) TGTGTA/GTGTGT 1 -- ds50010--------
    rs1922013671,2
    --133633633(+) TGTGTC/GTGTGT 1 -- ds50010--------
    rs1470240041,2
    --133633717(+) CCTCCA/CGGATT 1 -- ds50010--------
    rs1827637121,2
    --133633787(+) ACCCAC/GCTAAT 1 -- ds50010--------
    rs1138357501,2
    C,F--133633844(+) GGTTTC/TGAACT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1423695371,2
    --133633921(+) CACCCA/GGCCAT 1 -- ds50010--------
    rs1469031821,2
    C--133634014(+) CGAAGC/TTATGT 1 -- ds50010--------
    rs1878357251,2
    --133634048(+) TAAGTA/GTAAGT 1 -- ds50010--------
    rs1483860101,2
    --133634217(+) AAAAGC/GTGGAT 1 -- ut310--------
    rs1145583211,2
    C,F--133634293(+) AAAACG/AGGAAG 1 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CDKL3 (133541305 - 133706738 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDKL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6336n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): CDKL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDKL3
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608459    OMIM disorders: --

    2 diseases for CDKL3:    
    About MalaCards
    chromosome 5q deletion    mental retardation


    CDKL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDKL3
    Human Genome Epidemiology (HuGE) Navigator: CDKL3 (1 document)

    Export disorders for CDKL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKL3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CDKL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. (PubMed id 10463609)1, 3 Midmer M....Zanke B.W. (Cancer Res. 1999)
    4. NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. (PubMed id 12927787)1, 9 Yee K.W....Minden M.D. (Biochem. Biophys. Res. Commun. 2003)
    5. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. (PubMed id 17945021)1, 9 Jaluria P....Shiloach J. (BMC Biotechnol. 2007)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation. (PubMed id 18412109)1 Dubos A....Hanauer A. (Am. J. Med. Genet. A 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51265 HGNC: 15483 AceView: CDKL3.1 Ensembl:ENSG00000006837 euGenes: HUgn51265
    ECgene: CDKL3 H-InvDB: CDKL3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDKL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDKL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDKL3 gene:
    Search GeneIP for patents involving CDKL3

    GeneCards and IP:
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