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Aliases for CDKL3 Gene

Aliases for CDKL3 Gene

  • Cyclin-Dependent Kinase-Like 3 2 3
  • Serine-Threonine Protein Kinase NKIAMRE 2 3
  • EC 2.7.11.22 4 63
  • NKIAMRE 3 4
  • Serine/Threonine-Protein Kinase NKIAMRE 4
  • EC 2.7.11 63

External Ids for CDKL3 Gene

Previous GeneCards Identifiers for CDKL3 Gene

  • GC05M133292
  • GC05M134158
  • GC05M133664
  • GC05M133710
  • GC05M133662
  • GC05M128818
  • GC05M133541

Summaries for CDKL3 Gene

Entrez Gene Summary for CDKL3 Gene

  • The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKL3 Gene

CDKL3 (Cyclin-Dependent Kinase-Like 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL3 Gene

Genomics for CDKL3 Gene

Regulatory Elements for CDKL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDKL3 Gene

Chromosome:
5
Start:
134,236,120 bp from pter
End:
134,371,469 bp from pter
Size:
135,350 bases
Orientation:
Minus strand

Genomic View for CDKL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL3 Gene

Proteins for CDKL3 Gene

  • Protein details for CDKL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW4-CDKL3_HUMAN
    Recommended name:
    Cyclin-dependent kinase-like 3
    Protein Accession:
    Q8IVW4
    Secondary Accessions:
    • D3DQA0
    • D3DQA1
    • Q9P114

    Protein attributes for CDKL3 Gene

    Size:
    592 amino acids
    Molecular mass:
    67514 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDKL3 Gene

    Alternative splice isoforms for CDKL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDKL3 Gene

Proteomics data for CDKL3 Gene at MOPED

Selected DME Specific Peptides for CDKL3 Gene

Post-translational modifications for CDKL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDKL3 Gene

Gene Families for CDKL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVW4

UniProtKB/Swiss-Prot:

CDKL3_HUMAN :
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL3: view

Function for CDKL3 Gene

Molecular function for CDKL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for CDKL3 Gene

Gene Ontology (GO) - Molecular Function for CDKL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10463609
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with CDKL3: view
genes like me logo Genes that share phenotypes with CDKL3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKL3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKL3 Gene

Localization for CDKL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDKL3 Gene COMPARTMENTS Subcellular localization image for CDKL3 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CDKL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDKL3: view

Pathways & Interactions for CDKL3 Gene

SuperPathways for CDKL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10463609
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDKL3: view

No data available for Pathways by source and SIGNOR curated interactions for CDKL3 Gene

Drugs & Compounds for CDKL3 Gene

(1) Drugs for CDKL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDKL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CDKL3: view

Transcripts for CDKL3 Gene

mRNA/cDNA for CDKL3 Gene

(26) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDKL3 Gene

Cyclin-dependent kinase-like 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - - -
SP3:
SP4: - -

Relevant External Links for CDKL3 Gene

GeneLoc Exon Structure for
CDKL3
ECgene alternative splicing isoforms for
CDKL3

Expression for CDKL3 Gene

mRNA expression in normal human tissues for CDKL3 Gene

mRNA differential expression in normal tissues according to GTEx for CDKL3 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CDKL3 Gene

This gene is overexpressed in Plasma (31.3), Bone marrow mesenchymal stem cell (19.7), Liver, secretome (10.7), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDKL3 Gene



SOURCE GeneReport for Unigene cluster for CDKL3 Gene Hs.719926

genes like me logo Genes that share expression patterns with CDKL3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDKL3 Gene

Orthologs for CDKL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDKL3 35
  • 90.41 (n)
  • 85.45 (a)
CDKL3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDKL3 35
  • 91.54 (n)
  • 87.48 (a)
PPP2CA 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkl3 35
  • 83.14 (n)
  • 81.05 (a)
Cdkl3 16
Cdkl3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDKL3 35
  • 99.83 (n)
  • 99.66 (a)
CDKL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdkl3 35
  • 82.78 (n)
  • 81.98 (a)
oppossum
(Monodelphis domestica)
Mammalia CDKL3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDKL3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDKL3 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7236 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y42A5A.4 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for CDKL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDKL3 Gene

ENSEMBL:
Gene Tree for CDKL3 (if available)
TreeFam:
Gene Tree for CDKL3 (if available)

Paralogs for CDKL3 Gene

Paralogs for CDKL3 Gene

genes like me logo Genes that share paralogs with CDKL3: view

Variants for CDKL3 Gene

Sequence variations from dbSNP and Humsavar for CDKL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_041991 -

Structural Variations from Database of Genomic Variants (DGV) for CDKL3 Gene

Variant ID Type Subtype PubMed ID
dgv6336n71 CNV Loss 21882294

Variation tolerance for CDKL3 Gene

Residual Variation Intolerance Score: 85.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDKL3 Gene

HapMap Linkage Disequilibrium report
CDKL3
Human Gene Mutation Database (HGMD)
CDKL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL3 Gene

Disorders for CDKL3 Gene

Relevant External Links for CDKL3

Genetic Association Database (GAD)
CDKL3
Human Genome Epidemiology (HuGE) Navigator
CDKL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDKL3
genes like me logo Genes that share disorders with CDKL3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDKL3 Gene

Publications for CDKL3 Gene

  1. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. (PMID: 17945021) Jaluria P. … Shiloach J. (BMC Biotechnol. 2007) 23 67
  2. NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. (PMID: 12927787) Yee K.W. … Minden M.D. (Biochem. Biophys. Res. Commun. 2003) 23 67
  3. Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. (PMID: 10463609) Midmer M. … Zanke B.W. (Cancer Res. 1999) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for CDKL3 Gene

Sources for CDKL3 Gene

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