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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDKL2 Gene

protein-coding   GIFtS: 52
GCID: GC04M076501

cyclin-dependent kinase-like 2 (CDC2-related kinase)
 Explore 3 diseases affiliated with
CDKL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDKL2    

Aliases
for CDKL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase)1 2     CDC2-Related Kinase2
KKIAMRE1 2     Cyclin-Dependent Kinase-Like 22
P561 2     P56 KKIAMRE Protein Kinase2
Protein Kinase P56 KKIAMRE2 3     Serine/Threonine Protein Kinase KKIAMRE2
Serine/Threonine-Protein Kinase KKIAMRE2 3     EC 2.7.118
EC 2.7.11.223 8     

External Ids:    HGNC: 17821   Entrez Gene: 89992   Ensembl: ENSG000001387697   OMIM: 6034425   UniProtKB: Q927723   

Export aliases for CDKL2 gene to outside databases

Previous GC identifers: GC04M076400 GC04M076694 GC04M076896 GC04M076962 GC04M076861 GC04M072248


Summaries
for CDKL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDKL2:
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates
primarily in the cytoplasm, with lower levels in the nucleus. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CDKL2


Genomic Views
for CDKL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKL2 gene promoter:
         AML1a   HTF   XBP-1   CUTL1   Nkx5-1   AREB6   Egr-2   S8   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDKL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDKL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDKL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.21

CDKL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076501:  view genomic region     (about GC identifiers)

Start:
 76,501,704 bp from pter      End:
 76,555,900 bp from pter
Size:
 54,197 bases      Orientation:
 minus strand

Proteins
for CDKL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772 (See protein sequence)
Recommended Name: Cyclin-dependent kinase-like 2  
Size: 493 amino acids; 56019 Da
Subcellular location: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for CDKL2:
4AAA (3D)        4BBM (3D)    
Secondary accessions: B2R695

Explore the universe of human proteins at neXtProt for CDKL2: NX_Q92772

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92772

    • 4/15 DME Specific Peptides for CDKL2 (Q92772) (see all 15)
     INSGMGT  HENLVNL  VDVWAIG  KKFLESD 

    CDKL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003939.1  
    ENSEMBL proteins: 
     ENSP00000412365   ENSP00000306340   ENSP00000422666  

    Human Recombinant Protein Products: 
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    Novus Biologicals CDKL2 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDKL2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--


    CDKL2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CDKL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDKL2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q92772

    ProtoNet protein and cluster: Q92772

    UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772
    Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDKL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDKL2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKL2 (see all 26):
    hsa-miR-411* hsa-miR-34b* hsa-miR-379* hsa-miR-181c hsa-miR-1224-3p hsa-miR-29a hsa-miR-29c hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmid: CDKL2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKL2 (see all 7)
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CDKL2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9000130
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005524ATP binding IEA--


    CDKL2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CDKL2:
     Decreased substrate adherent c  Decreased telomerase activity  Increased cell number in G2M,  

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cdkl2):
     no phenotypic analysis 

    CDKL2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDKL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for CDKL2 (Q927723 ENSP000003063404) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226813, ENSP000002640334I2D: score=1 STRING: ENSP00000264033
    PSMC2ENSP000002926444STRING: ENSP00000292644
    PSMD5ENSP000002103134STRING: ENSP00000210313
    PSMD14ENSP000003865414STRING: ENSP00000386541
    UCHL5ENSP000003564254STRING: ENSP00000356425
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS9000130
    GO:0007548sex differentiation TAS9000130


    CDKL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDKL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDKL2

    2 HMDB Compounds for CDKL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about CDKL2 

    Transcripts
    for CDKL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDKL2 gene: 
    NM_003948.3  

    Unigene Cluster for CDKL2:

    Cyclin-dependent kinase-like 2 (CDC2-related kinase)
    Hs.591698  [show with all ESTs]
    Unigene Representative Sequence: NM_003948
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429927(uc003hiq.3 uc011cbp.2 uc010iix.1) ENST00000307465
    ENST00000515793 ENST00000506234

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CDKL2 (see all 26):
    hsa-miR-411* hsa-miR-34b* hsa-miR-379* hsa-miR-181c hsa-miR-1224-3p hsa-miR-29a hsa-miR-29c hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmid: CDKL2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDKL2 (see all 7)
    OriGene shRNA RFP: CDKL2
    OriGene siRNA: CDKL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDKL2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDKL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDKL2

    Additional cDNA sequence: 

    AK294866.1 AK309127.1 AK312490.1 BC017417.1 BC093646.1 BC093981.1 U35146.1 

    4 DOTS entries:

    DT.65287385  DT.101960224  DT.100740018  DT.40218422 

    24/40 AceView cDNA sequences (see all 40):

    AL046789 CR607098 N34890 CB240964 NM_003948 BU078950 U35146 AI138780 
    CA311652 AW163011 BC017417 AW157044 AW299729 Z40321 Z44390 AA770409 
    AA609642 BX088820 BX452026 BX412919 CB134655 CK824931 BX095447 BG534836 

    GeneLoc Exon Structure


    Expression
    for CDKL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDKL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAGGGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDKL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDKL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDKL2

    SOURCE GeneReport for Unigene cluster: Hs.591698

    UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772
    Tissue specificity: Expressed in testis and kidney, and at lower level in brain and lung

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    In Situ
    Assay Products:     
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    Orthologs
    for CDKL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDKL2 gene from 2/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDKL21 cyclin-dependent kinase-like 2 (CDC2-related kinase) 69.73(n)
    70.24(a)    		   428736  XM_426294.3  XP_426294.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CDKL26
    		 --
    		 61(a)
    		 1 ↔ 1
    		 6(59152611-59169854)


    ENSEMBL Gene Tree for CDKL2 (if available)
    TreeFam Gene Tree for CDKL2 (if available) 

    Paralogs
    for CDKL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDKL2 gene
    CDKL12  CDKL52  MOK2  CDKL32  MAK2  CDKL42  ICK2  
    18/52 SIMAP similar genes for CDKL2 using alignment to 3 protein entries:     CDKL2_HUMAN (see all proteins) (see all similar genes):
    CDKL1    CDKL4    CDC2    CDK12    STK3    STK4
    CDK1    CDK3    CDKL3    CDK7    MAPK8    CCRK
    CDKL5    DKFZp686L20222    MAPK7    CDK14    CDK20    CDK5

    CDKL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDKL2
    PGOHUM00000245594


    Genomic Variants
    for CDKL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDKL2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKL2

    Disorders / Diseases
    for CDKL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDKL2 for disorders           About GeneDecksing

    OMIM gene information: 603442    OMIM disorders: --

    3 diseases for CDKL2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    angiomyolipoma


    Export disorders for CDKL2 gene to outside databases

    Publications
    for CDKL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDKL2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CDKL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PubMed id 9000130)1, 2, 3 Taglienti C.A.... Davis R.J. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    6. Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck). (PubMed id 16631599)1 Marracci G.H....Bourdette D.N. (2006)
    7. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. (PubMed id 15502848)1 Sarkar S.N....Sen G.C. (2004)
    8. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. (PubMed id 15499549)1 Tao J.... Kalscheuer V.M. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CDKL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDKL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8999 HGNC: 1782 AceView: CDKL2 Ensembl:ENSG00000138769 euGenes: HUgn8999
    ECgene: CDKL2 H-InvDB: CDKL2

    Other Databases showing CDKL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDKL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDKL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDKL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDKL2 gene:
    Search GeneIP for patents involving CDKL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDKL2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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     Browse OriGene Antibodies   OriGene shRNA RFP for CDKL2  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDKL2
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     GenScript Custom Purified and Recombinant Proteins Services for CDKL2 GenScript cDNA clones with any tag delivered in your preferred vector for CDKL2
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     Regulatory tfbs in CDKL2 promoter
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Search for Antibodies for CDKL2 at Abcam
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     CDKL2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CDKL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL2
     SwitchGear 3'UTR luciferase reporter plasmids for CDKL2
     SwitchGear Promoter luciferase reporter plasmids for CDKL2
     Search ThermoFisher Antibodies for CDKL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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