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Aliases for CDKL2 Gene

Aliases for CDKL2 Gene

  • Cyclin Dependent Kinase Like 2 2 3
  • Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) 2 3 5
  • Serine/Threonine-Protein Kinase KKIAMRE 3 4
  • Protein Kinase P56 KKIAMRE 3 4
  • EC 4 63
  • Serine/Threonine Protein Kinase KKIAMRE 3
  • Testicular Tissue Protein Li 35 3
  • P56 KKIAMRE Protein Kinase 3
  • CDC2-Related Kinase 3
  • EC 2.7.11 63
  • P56 3

External Ids for CDKL2 Gene

Previous GeneCards Identifiers for CDKL2 Gene

  • GC04M076400
  • GC04M076694
  • GC04M076896
  • GC04M076962
  • GC04M076861
  • GC04M076501
  • GC04M072248

Summaries for CDKL2 Gene

Entrez Gene Summary for CDKL2 Gene

  • This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKL2 Gene

CDKL2 (Cyclin Dependent Kinase Like 2) is a Protein Coding gene. Diseases associated with CDKL2 include Joubert Syndrome With Orofaciodigital Defect and Meckel Syndrome 1. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3.

Gene Wiki entry for CDKL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL2 Gene

Genomics for CDKL2 Gene

Regulatory Elements for CDKL2 Gene

Enhancers for CDKL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDKL2 on UCSC Golden Path with GeneCards custom track

Promoters for CDKL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDKL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDKL2 Gene

75,576,494 bp from pter
75,630,716 bp from pter
54,223 bases
Minus strand

Genomic View for CDKL2 Gene

Genes around CDKL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL2 Gene

Proteins for CDKL2 Gene

  • Protein details for CDKL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase-like 2
    Protein Accession:
    Secondary Accessions:
    • B2R695

    Protein attributes for CDKL2 Gene

    493 amino acids
    Molecular mass:
    56019 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDKL2 Gene

neXtProt entry for CDKL2 Gene

Proteomics data for CDKL2 Gene at MOPED

Post-translational modifications for CDKL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CDKL2 Gene

Suggested Antigen Peptide Sequences for CDKL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL2: view

Function for CDKL2 Gene

Molecular function for CDKL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for CDKL2 Gene

Gene Ontology (GO) - Molecular Function for CDKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9000130
genes like me logo Genes that share ontologies with CDKL2: view
genes like me logo Genes that share phenotypes with CDKL2: view

Animal Models for CDKL2 Gene

MGI Knock Outs for CDKL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDKL2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDKL2 Gene

Localization for CDKL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CDKL2 Gene COMPARTMENTS Subcellular localization image for CDKL2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with CDKL2: view

Pathways & Interactions for CDKL2 Gene

SuperPathways for CDKL2 Gene

No Data Available

Pathways by source for CDKL2 Gene

1 GeneTex pathway for CDKL2 Gene

Interacting Proteins for CDKL2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000412365 Q92772-CDKL2_HUMAN for CDKL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CDKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9000130
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDKL2: view

No data available for SIGNOR curated interactions for CDKL2 Gene

Drugs & Compounds for CDKL2 Gene

(1) Drugs for CDKL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDKL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDKL2: view

Transcripts for CDKL2 Gene

Unigene Clusters for CDKL2 Gene

Cyclin-dependent kinase-like 2 (CDC2-related kinase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL2 Gene

No ASD Table

Relevant External Links for CDKL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKL2 Gene

mRNA expression in normal human tissues for CDKL2 Gene

mRNA differential expression in normal tissues according to GTEx for CDKL2 Gene

This gene is overexpressed in Testis (x4.5) and Brain - Frontal Cortex (BA9) (x4.1).

SOURCE GeneReport for Unigene cluster for CDKL2 Gene Hs.591698

mRNA Expression by UniProt/SwissProt for CDKL2 Gene

Tissue specificity: Expressed in testis and kidney, and at lower level in brain and lung.
genes like me logo Genes that share expression patterns with CDKL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CDKL2 Gene

Orthologs for CDKL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDKL2 35
  • 89.8 (n)
  • 89.24 (a)
CDKL2 36
  • 77 (a)
(Canis familiaris)
Mammalia CDKL2 35
  • 92.32 (n)
  • 90.7 (a)
CDKL2 36
  • 78 (a)
(Mus musculus)
Mammalia Cdkl2 35
  • 87.16 (n)
  • 87.87 (a)
Cdkl2 16
Cdkl2 36
  • 75 (a)
(Pan troglodytes)
Mammalia CDKL2 35
  • 92.57 (n)
  • 91.82 (a)
CDKL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cdkl2 35
  • 85.06 (n)
  • 85.89 (a)
(Monodelphis domestica)
Mammalia CDKL2 36
  • 56 (a)
(Gallus gallus)
Aves CDKL2 35
  • 69.73 (n)
  • 70.24 (a)
CDKL2 36
  • 59 (a)
(Anolis carolinensis)
Reptilia CDKL2 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkl2 35
  • 66.05 (n)
  • 65.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7236 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea Y42A5A.4 37
  • 52 (a)
Y42A5A.4 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9638 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
Species with no ortholog for CDKL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDKL2 Gene

Gene Tree for CDKL2 (if available)
Gene Tree for CDKL2 (if available)

Paralogs for CDKL2 Gene

Paralogs for CDKL2 Gene Pseudogenes for CDKL2 Gene

genes like me logo Genes that share paralogs with CDKL2: view

Variants for CDKL2 Gene

Sequence variations from dbSNP and Humsavar for CDKL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_041987 An ovarian papillary serous adenocarcinoma sample
VAR_041988 An ovarian mucinous carcinoma sample
rs56343717 - 75,605,587(+) CCCCC(A/G)TGAAC reference, missense
rs56231363 - 75,597,025(+) GAATT(A/G)CCACG reference, missense
rs35921414 - 75,614,388(+) CTAGG(G/T)ACCAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDKL2 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv879495 CNV Loss 21882294
dgv5637n71 CNV Loss 21882294

Variation tolerance for CDKL2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDKL2 Gene

Disorders for CDKL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDKL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
joubert syndrome with orofaciodigital defect
  • orofaciodigital syndrome vi
meckel syndrome 1
  • meckel syndrome
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CDKL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDKL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDKL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKL2 Gene

Publications for CDKL2 Gene

  1. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PMID: 9000130) Taglienti C.A. … Davis R.J. (Oncogene 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression. (PMID: 25333262) Li L. … Li W. (Oncotarget 2014) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for CDKL2 Gene

Sources for CDKL2 Gene