Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDKL2 Gene

protein-coding   GIFtS: 55
GCID: GC04M076501

Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase)1 2     CDC2-Related Kinase2
Protein Kinase P56 KKIAMRE2 3     Cyclin-Dependent Kinase-Like 22
Serine/Threonine-Protein Kinase KKIAMRE2 3     P56 KKIAMRE Protein Kinase2
EC 2.7.11.223 8     Serine/Threonine Protein Kinase KKIAMRE2
KKIAMRE2 5     EC 2.7.118
P562 5     

External Ids:    HGNC: 17821   Entrez Gene: 89992   Ensembl: ENSG000001387697   OMIM: 6034425   UniProtKB: Q927723   

Export aliases for CDKL2 gene to outside databases

Previous GC identifers: GC04M076400 GC04M076694 GC04M076896 GC04M076962 GC04M076861 GC04M072248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDKL2 Gene:
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates
primarily in the cytoplasm, with lower levels in the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDKL2 Gene:
CDKL2 (cyclin-dependent kinase-like 2 (CDC2-related kinase)) is a protein-coding gene. Diseases associated with CDKL2 include angiomyolipoma, and systemic lupus erythematosus. GO annotations related to this gene include protein kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL1.

Gene Wiki entry for CDKL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDKL2 gene promoter:
         AML1a   HTF   XBP-1   CUTL1   Nkx5-1   AREB6   Egr-2   S8   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDKL2 promoter sequence
   Search Chromatin IP Primers for CDKL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.21

CDKL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076501:  view genomic region     (about GC identifiers)

Start:
76,501,704 bp from pter      End:
76,555,900 bp from pter
Size:
54,197 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772 (See protein sequence)
Recommended Name: Cyclin-dependent kinase-like 2  
Size: 493 amino acids; 56019 Da
2 PDB 3D structures from and Proteopedia for CDKL2:
4AAA (3D)        4BBM (3D)    
Secondary accessions: B2R695

Explore the universe of human proteins at neXtProt for CDKL2: NX_Q92772

Explore proteomics data for CDKL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn310
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDKL2 (Q92772) (see all 15)
     INSGMGT  HENLVNL  VDVWAIG  KKFLESD 


    See CDKL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003939.1  
    ENSEMBL proteins: 
     ENSP00000412365   ENSP00000306340   ENSP00000422666  

    CDKL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDKL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDKL2
    GenScript Custom Purified and Recombinant Proteins Services for CDKL2
    Novus Biologicals CDKL2 Protein
    Novus Biologicals CDKL2 Lysate
    Sino Biological Recombinant Protein for CDKL2
    Sino Biological Cell Lysate for CDKL2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDKL2

    CDKL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDKL2
    OriGene Custom Antibody Services for CDKL2
    Novus Biologicals CDKL2 Antibodies
    Abcam antibodies for CDKL2
    Cloud-Clone Corp. Antibodies for CDKL2
    Search ThermoFisher Antibodies for CDKL2
    LSBio Antibodies in human, mouse, rat for CDKL2

    CDKL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDKL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDKL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDKL2
    Cloud-Clone Corp. CLIAs for CDKL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase-like 2 (CDC2-related kinase)
    Cyclin-dependent kinase-like (CDKL) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q92772

    ProtoNet protein and cluster: Q92772

    UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772
    Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDKL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDKL2_HUMAN, Q92772
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9000130
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    CDKL2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDKL2:
     Decreased substrate adherent c  Decreased telomerase activity  Increased cell number in G2M,  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cdkl2):
     no phenotypic analysis 

    CDKL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDKL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDKL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDKL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDKL2:
    hsa-mir-26b-5p (MIRT028804)

    Block miRNA regulation of human, mouse, rat CDKL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKL2 (see all 26):
    hsa-miR-411* hsa-miR-34b* hsa-miR-379* hsa-miR-181c hsa-miR-1224-3p hsa-miR-29a hsa-miR-29c hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidCDKL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDKL2
    Predesigned siRNA for gene silencing in human, mouse, rat CDKL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDKL2

    Clone
    Products:
         
    OriGene clones in human, mouse for CDKL2 (see all 8)
    OriGene ORF clones in mouse, rat for CDKL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDKL2 (NM_003948)
    Sino Biological Human cDNA Clone for CDKL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDKL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDKL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CDKL2_HUMAN, Q92772: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome ----

    CDKL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDKL2
    Interactions:

        GeneGlobe Interaction Network for CDKL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CDKL2 (Q927723 ENSP000003063404) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226813, ENSP000002640334I2D: score=1 STRING: ENSP00000264033
    PSMC2ENSP000002926444STRING: ENSP00000292644
    PSMD5ENSP000002103134STRING: ENSP00000210313
    PSMD14ENSP000003865414STRING: ENSP00000386541
    UCHL5ENSP000003564254STRING: ENSP00000356425
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS9000130
    GO:0007548sex differentiation TAS9000130

    CDKL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKL2

    2 HMDB Compounds for CDKL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDKL2 gene: 
    NM_003948.3  

    Unigene Cluster for CDKL2:

    Cyclin-dependent kinase-like 2 (CDC2-related kinase)
    Hs.591698  [show with all ESTs]
    Unigene Representative Sequence: NM_003948
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429927(uc003hiq.3 uc011cbp.2 uc010iix.1) ENST00000307465
    ENST00000515793 ENST00000506234
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDKL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDKL2 (see all 26):
    hsa-miR-411* hsa-miR-34b* hsa-miR-379* hsa-miR-181c hsa-miR-1224-3p hsa-miR-29a hsa-miR-29c hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidCDKL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDKL2
    Predesigned siRNA for gene silencing in human, mouse, rat CDKL2
    Clone
    Products:
         
    OriGene clones in human, mouse for CDKL2 (see all 8)
    OriGene ORF clones in mouse, rat for CDKL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDKL2 (NM_003948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDKL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDKL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CDKL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKL2
      QuantiTect SYBR Green Assays in human, mouse, rat CDKL2
      QuantiFast Probe-based Assays in human, mouse, rat CDKL2

    Additional mRNA sequence: 

    AK294866.1 AK309127.1 AK312490.1 BC017417.1 BC093646.1 BC093981.1 U35146.1 

    4 DOTS entries:

    DT.65287385  DT.101960224  DT.100740018  DT.40218422 

    Selected AceView cDNA sequences (see all 40):

    U35146 AW157044 CR607098 AI138780 CB240964 NM_003948 AW163011 AL046789 
    BU078950 CA311652 BC017417 N34890 BX095447 BX452026 CB134655 BU078673 
    AA609642 Z40321 AA770409 BX452025 Z44390 BG534836 BX507734 BX088820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDKL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAGGGGAT
    CDKL2 Expression
    About this image

    CDKL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591698

    UniProtKB/Swiss-Prot: CDKL2_HUMAN, Q92772
    Tissue specificity: Expressed in testis and kidney, and at lower level in brain and lung

        Custom PCR Arrays for CDKL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDKL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CDKL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKL2
    QuantiTect SYBR Green Assays in human, mouse, rat CDKL2
    QuantiFast Probe-based Assays in human, mouse, rat CDKL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CDKL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkl21 , 5 cyclin-dependent kinase-like 2 (CDC2-related kinase)1, 5 87.16(n)1
    87.87(a)1
      5 (45.73 cM)5
    538861  NM_016912.21  NP_058608.11 
     920060745 
    chicken
    (Gallus gallus)
    Aves CDKL21 cyclin-dependent kinase-like 2 (CDC2-related kinase) 69.73(n)
    70.24(a)
      428736  XM_426294.4  XP_426294.4 
    lizard
    (Anolis carolinensis)
    Reptilia CDKL26
    cyclin-dependent kinase-like 2 (CDC2-related kinas...
    62(a)
    1 ↔ 1
    6(59145652-59172007)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdkl21 cyclin-dependent kinase-like 2 (CDC2-related kinase) 66.05(n)
    65.64(a)
      100487310  XM_002938622.2  XP_002938668.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72366
    --
    34(a)
    1 → many
    2L(5708449-5713648)
    worm
    (Caenorhabditis elegans)
    Secernentea Y42A5A.43 Eukaryotic protein kinase domain 52(a)   V(11108095-11109872)   --


    ENSEMBL Gene Tree for CDKL2 (if available)
    TreeFam Gene Tree for CDKL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDKL2 gene
    CDKL12  CDK202  CDKL52  CDKL32  CDK72  CDKL42  
    Selected SIMAP similar genes for CDKL2 using alignment to 3 protein entries:     CDKL2_HUMAN (see all proteins) (see all similar genes):
    CDKL1    CDKL4    CDC2    CDK12    STK3    STK4
    CDK1    CDK3    CDKL3    CDK7    MAPK8    CCRK
    CDKL5    DKFZp686L20222    MAPK7    CDK14    CDK20    CDK5

    CDKL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDKL2
    PGOHUM00000245594


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CDKL2 (see all 1023)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419874
    An ovarian papillary serous adenocarcinoma sample4--see VAR_0419872 L I mis40--------
    VAR_0419884
    An ovarian mucinous carcinoma sample4--see VAR_0419882 R Q mis40--------
    rs610697571,2
    C--76364880(+) TTTTT-/T/TT  
            
    GAGAT
    1 -- int11NA 2
    rs1392743581,2
    --76501277(+) GAATTA/GAGATA 1 -- ds50010--------
    rs172807141,2
    C,F--76501309(+) CCTTTC/TTTATA 1 -- ds50017Minor allele frequency- T:0.14NA EA WA 570
    rs1825223951,2
    --76501337(+) AATACA/GTTTTC 1 -- ds50010--------
    rs1417498901,2
    --76501341(+) CATTTC/TCCAAA 1 -- ds50010--------
    rs1167917691,2
    C,F--76501604(+) TCAGAG/AGGCAT 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1147825471,2
    F--76501605(+) CAGAGG/AGCATG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1868047891,2
    --76501799(+) AAAAAA/TCCATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDKL2 (76501704 - 76555900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDKL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879495CNV Loss21882294
    dgv5637n71CNV Loss21882294
    nsv7363OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDKL2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDKL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603442    OMIM disorders: --

    3 diseases for CDKL2:    
    About MalaCards
    angiomyolipoma    systemic lupus erythematosus    lupus erythematosus


    CDKL2 for disorders           About GeneDecksing


    Export disorders for CDKL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDKL2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CDKL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PubMed id 9000130)1, 2, 3 Taglienti C.A.... Davis R.J. (Oncogene 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    7. Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck). (PubMed id 16631599)1 Marracci G.H....Bourdette D.N. (Biochem. Biophys. Res. Commun. 2006)
    8. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. (PubMed id 15502848)1 Sarkar S.N....Sen G.C. (amp 2004)
    9. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. (PubMed id 15499549)1 Tao J.... Kalscheuer V.M. (Am. J. Hum. Genet. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8999 HGNC: 1782 AceView: CDKL2 Ensembl:ENSG00000138769 euGenes: HUgn8999
    ECgene: CDKL2 H-InvDB: CDKL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDKL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDKL2 gene:
    Search GeneIP for patents involving CDKL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDKL2   OriGene RNAi products in human, mouse, rat for CDKL2  
     OriGene qPCR primer pairs and template standards for CDKL2   OriGene Protein Over-expression Lysate for CDKL2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDKL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDKL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CDKL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDKL2   OriGene Custom Protein Services for CDKL2  

     
     
     Block miRNA regulation of human, mouse, rat CDKL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDKL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKL2 Predesigned siRNA for gene silencing in human, mouse, rat CDKL2
     QuantiFast Probe-based Assays in human, mouse, rat CDKL2 QuantiTect SYBR Green Assays in human, mouse, rat CDKL2
     Custom PCR Arrays for CDKL2 Search Chromatin IP Primers for CDKL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKL2  GeneGlobe Interaction Network for CDKL2
     Regulatory tfbs in CDKL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CDKL2 GenScript cDNA clones with any tag delivered in your preferred vector for CDKL2
     GenScript Custom Assay Services for CDKL2 GenScript Custom overexpressing Cell Line Services for CDKL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CDKL2
     Proteins for CDKL2
     Cell Lysates for CDKL2
     cDNA Clones for CDKL2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDKL2 antibodies
     CDKL2 proteins
     CDKL2 lysates
     Antibodies for CDKL2
     See all of Abcam's Antibodies, Kits and Proteins for CDKL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CDKL2
     Antibodies for CDKL2
     ELISAs for CDKL2
     CLIAs for CDKL2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDKL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL2
     SwitchGear 3'UTR luciferase reporter plasmids for CDKL2
     SwitchGear Promoter luciferase reporter plasmids for CDKL2
     Search ThermoFisher Antibodies for CDKL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDKL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDKL2
     LSBio Antibodies in human, mouse, rat for CDKL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDKL2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4