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Aliases for CDKL1 Gene

Aliases for CDKL1 Gene

  • Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase) 2 3
  • Serine/Threonine-Protein Kinase KKIALRE 3 4
  • Protein Kinase P42 KKIALRE 3 4
  • EC 4 63
  • KKIALRE 3 6
  • P42 3 6
  • Serine/Threonine Protein Kinase KKIALRE 3
  • Cyclin-Dependent Kinase-Like 1 3
  • CDC2-Related Kinase 1 3
  • EC 2.7.11 63

External Ids for CDKL1 Gene

Previous GeneCards Identifiers for CDKL1 Gene

  • GC14M048118
  • GC14M044592
  • GC14M048786
  • GC14M049866
  • GC14M050796
  • GC14M030921

Summaries for CDKL1 Gene

Entrez Gene Summary for CDKL1 Gene

  • This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for CDKL1 Gene

CDKL1 (Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase)) is a Protein Coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL1 Gene

Genomics for CDKL1 Gene

Regulatory Elements for CDKL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDKL1 Gene

50,329,404 bp from pter
50,416,461 bp from pter
87,058 bases
Minus strand

Genomic View for CDKL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL1 Gene

Proteins for CDKL1 Gene

  • Protein details for CDKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase-like 1
    Protein Accession:
    Secondary Accessions:
    • Q2M3A4
    • Q6QUA0
    • Q8WXQ5

    Protein attributes for CDKL1 Gene

    357 amino acids
    Molecular mass:
    41671 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI04978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAS00095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA47002.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDKL1 Gene

    Alternative splice isoforms for CDKL1 Gene


neXtProt entry for CDKL1 Gene

Proteomics data for CDKL1 Gene at MOPED

Selected DME Specific Peptides for CDKL1 Gene

Post-translational modifications for CDKL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKL1 Gene

Antibody Products

Domains for CDKL1 Gene

Gene Families for CDKL1 Gene

Suggested Antigen Peptide Sequences for CDKL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q00532
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL1: view

Function for CDKL1 Gene

Molecular function for CDKL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for CDKL1 Gene

Gene Ontology (GO) - Molecular Function for CDKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDKL1: view
genes like me logo Genes that share phenotypes with CDKL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDKL1 Gene

Localization for CDKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CDKL1 Gene COMPARTMENTS Subcellular localization image for CDKL1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with CDKL1: view

Pathways for CDKL1 Gene

SuperPathways for CDKL1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CDKL1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000379176 Q00532-CDKL1_HUMAN for CDKL1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CDKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007507 heart development IEA --
GO:0051726 regulation of cell cycle TAS 1639063
genes like me logo Genes that share ontologies with CDKL1: view

No data available for Pathways by source for CDKL1 Gene

Compounds for CDKL1 Gene

(2) HMDB Compounds for CDKL1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(1) Novoseek inferred chemical compound relationships for CDKL1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 21.6 3
genes like me logo Genes that share compounds with CDKL1: view

Transcripts for CDKL1 Gene

Unigene Clusters for CDKL1 Gene

Cyclin-dependent kinase-like 1 (CDC2-related kinase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: - - - - -
SP4: - - - - - - - - -
SP5: -

ExUns: 23 ^ 24 ^ 25
SP3: -

Relevant External Links for CDKL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKL1 Gene

mRNA expression in normal human tissues for CDKL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CDKL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.3) and Heart (12.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CDKL1 Gene

SOURCE GeneReport for Unigene cluster for CDKL1 Gene Hs.679430

mRNA Expression by UniProt/SwissProt for CDKL1 Gene

Tissue specificity: Highly expressed in kidney, and to a lower extent in ovary.
genes like me logo Genes that share expressions with CDKL1: view

Expression partners for CDKL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDKL1 Gene

Orthologs for CDKL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDKL1 35
  • 90.15 (n)
  • 91.48 (a)
CDKL1 36
  • 91 (a)
(Canis familiaris)
Mammalia CDKL1 35
  • 90.04 (n)
  • 91.34 (a)
CDKL1 36
  • 90 (a)
(Mus musculus)
Mammalia Cdkl1 35
  • 85.51 (n)
  • 90.06 (a)
Cdkl1 16
Cdkl1 36
  • 90 (a)
(Pan troglodytes)
Mammalia CDKL1 35
  • 99.26 (n)
  • 98.88 (a)
CDKL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cdkl1 35
  • 85.42 (n)
  • 89.49 (a)
(Ornithorhynchus anatinus)
Mammalia CDKL1 36
  • 88 (a)
(Gallus gallus)
Aves CDKL1 35
  • 76.14 (n)
  • 83.81 (a)
CDKL1 36
  • 84 (a)
(Anolis carolinensis)
Reptilia CDKL1 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkl1 35
  • 75.35 (n)
  • 84.59 (a)
(Danio rerio)
Actinopterygii cdkl1 35
  • 70.58 (n)
  • 79.08 (a)
Dr.15600 35
cdkl1 36
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5209 35
fruit fly
(Drosophila melanogaster)
Insecta CG7236 37
  • 57 (a)
CG7236 35
  • 57.84 (n)
  • 60.88 (a)
CG7236 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003180 35
  • 60.37 (n)
  • 63.47 (a)
(Caenorhabditis elegans)
Secernentea Y42A5A.4 37
  • 59 (a)
CELE_Y42A5A.4 35
  • 62.38 (n)
  • 62.07 (a)
Y42A5A.4 36
  • 40 (a)
Species with no ortholog for CDKL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDKL1 Gene

Gene Tree for CDKL1 (if available)
Gene Tree for CDKL1 (if available)

Paralogs for CDKL1 Gene

Paralogs for CDKL1 Gene

genes like me logo Genes that share paralogs with CDKL1: view

Variants for CDKL1 Gene

Sequence variations from dbSNP and Humsavar for CDKL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11354767 -- 50,407,760(+) TTTTG(-/T)TTTTT intron-variant
rs11381667 -- 50,341,781(+) AAAAA(-/A)GTTCC intron-variant
rs11445321 -- 50,334,920(+) AGCAG(-/T)TTTTT intron-variant
rs11570779 -- 50,397,441(-) GCAGA(C/G)TCTGT upstream-variant-2KB, intron-variant
rs11570780 -- 50,396,811(-) CCGGG(A/C)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDKL1 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv832793 CNV Loss 17160897
nsv819725 CNV Gain 19587683
nsv820573 CNV Deletion 20802225
esv2657374 CNV Deletion 23128226
nsv1272 CNV Insertion 18451855

Relevant External Links for CDKL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL1 Gene

Disorders for CDKL1 Gene

Relevant External Links for CDKL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CDKL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CDKL1 Gene

Publications for CDKL1 Gene

  1. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PMID: 9000130) Taglienti C.A. … Davis R.J. (Oncogene 1996) 3 4 23
  2. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 2 3 4
  3. The distribution and biochemical properties of a Cdc2-related kinase, KKIALRE, in normal and Alzheimer brains. (PMID: 7595554) Yen S.H. … Dickson D.W. (J. Neurochem. 1995) 2 3
  4. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CDKL1 Gene

  • Addgene plasmids for CDKL1

Sources for CDKL1 Gene

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