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CDKL1 Gene

protein-coding   GIFtS: 52
GCID: GC14M050796

Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase)1 2     CDC2-Related Kinase 12
Protein Kinase P42 KKIALRE2 3     Cyclin-Dependent Kinase-Like 12
Serine/Threonine-Protein Kinase KKIALRE2 3     Serine/Threonine Protein Kinase KKIALRE2
EC 2.7.11.223 8     p425
KKIALRE2 5     EC 2.7.118
P422     

External Ids:    HGNC: 17811   Entrez Gene: 88142   Ensembl: ENSG000001004907   OMIM: 6034415   UniProtKB: Q005323   

Export aliases for CDKL1 gene to outside databases

Previous GC identifers: GC14M048118 GC14M044592 GC14M048786 GC14M049866 GC14M030921


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDKL1 Gene:
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates
primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Aug 2013)

GeneCards Summary for CDKL1 Gene:
CDKL1 (cyclin-dependent kinase-like 1 (CDC2-related kinase)) is a protein-coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK20.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDKL1 gene promoter:
         USF1   GATA-3   Nkx2-2   HSF1 (long)   USF2   USF-1:USF-2   USF-1   STAT3   HSF1short   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDKL1 promoter sequence
   Search Chromatin IP Primers for CDKL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDKL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.3   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21.3

CDKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKL1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050796:  view genomic region     (about GC identifiers)

Start:
50,796,310 bp from pter      End:
50,883,179 bp from pter
Size:
86,870 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532 (See protein sequence)
Recommended Name: Cyclin-dependent kinase-like 1  
Size: 357 amino acids; 41671 Da
Sequence caution: Sequence=AAI04978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAS00095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA47002.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CDKL1:
4AGU (3D)    
Secondary accessions: Q2M3A4 Q6QUA0 Q8WXQ5
Alternative splicing: 2 isoforms:  Q00532-1   Q00532-2   

Explore the universe of human proteins at neXtProt for CDKL1: NX_Q00532

Explore proteomics data for CDKL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDKL1 (Q00532) (see all 7)
     VDVWAIG  YVATRWYR  TGQIVAIK  IVAIKKFLES 


    See CDKL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269165.1  NP_004187.2  

    ENSEMBL proteins: 
     ENSP00000379176   ENSP00000431449   ENSP00000435044   ENSP00000216378  

    CDKL1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CDKL1
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    Novus Biologicals CDKL1 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDKL1

     
    Search eBioscience for Proteins for CDKL1 

     
    antibodies-online proteins for CDKL1 (3 products) 

     
    antibodies-online peptides for CDKL1

    CDKL1 Antibody Products:

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    antibodies-online kits for CDKL1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase-like 1 (CDC2-related kinase)
    Cyclin-dependent kinase-like (CDKL) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00532

    ProtoNet protein and cluster: Q00532

    UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532
    Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDKL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDKL1_HUMAN, Q00532
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDKL1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDKL1:
     Decreased 12E8 and total tau p  Decreased Hepatitis C virus re  Decreased substrate adherent c  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDKL1

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    GenScript: all cDNA clones in your preferred vector: CDKL1 (NM_004196)
    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for CDKL1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDKL1_HUMAN, Q00532: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CDKL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CDKL1: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDKL1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for CDKL1 (Q005323 ENSP000002163784) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    DVL2O146413I2D: score=1 
    DVL3Q929973I2D: score=1 
    --Q8NDD83I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS1639063
    GO:0007507heart development IEA--

    Find genes that share ontologies with CDKL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDKL1

    2 HMDB Compounds for CDKL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for CDKL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.6 3 7579336 (2), 17472728 (1)



    Find genes that share compounds with CDKL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDKL1 gene (2 alternative transcripts): 
    NM_001282236.1  NM_004196.4  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395834(uc001wxz.3) ENST00000525911 ENST00000534267 ENST00000216378
    ENST00000356146(uc010anu.2) ENST00000542671 ENST00000529347 ENST00000528197
    ENST00000531052 ENST00000530553 ENST00000534566
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDKL1
    Addgene plasmids for CDKL1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDKL1
      QuantiTect SYBR Green Assays in human, mouse, rat CDKL1
      QuantiFast Probe-based Assays in human, mouse, rat CDKL1

    Selected AceView cDNA sequences (see all 35):

    AF390028 BM700097 BF439746 NM_004196 BP349057 AI333007 AL047521 CN478950 
    AA927373 AA334399 CA334835 AK093741 BU737897 AI632347 AA680410 BE700389 
    AL603471 BX099583 AW237555 BE700387 BX498224 AA043556 BF507529 X66358 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDKL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                    -                 -     -                                                                       -           -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                        -     -     -     -     -     -     -     -           -                                             
    SP5:                                -                                                                                                                           

    ExUns: 23 ^ 24 ^ 25
    SP1:                  
    SP2:                  
    SP3:  -               
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CDKL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDKL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACAGCTG
    CDKL1 Expression
    About this image


    CDKL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Kidney (Urinary System)
    CDKL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDKL1 Protein Expression

    UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532
    Tissue specificity: Highly expressed in kidney, and to a lower extent in ovary

        Pathway & Disease-focused RT2 Profiler PCR Array including CDKL1: 
              Alzheimer's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDKL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDKL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdkl11 , 5 cyclin-dependent kinase-like 1 (CDC2-related kinase)1, 5 85.51(n)1
    90.06(a)1
      12 (28.94 cM)5
    710911  NM_183294.21  NP_899117.11 
     697468485 
    chicken
    (Gallus gallus)
    Aves CDKL11 cyclin-dependent kinase-like 1 (CDC2-related kinase) 76.14(n)
    83.81(a)
      423575  XM_421464.4  XP_421464.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDKL16
    cyclin-dependent kinase-like 1 (CDC2-related kinas...
    88(a)
    1 ↔ 1
    GL343627.1(144086-162601)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdkl11 cyclin-dependent kinase-like 1 (CDC2-related kinase) 75.35(n)
    84.59(a)
      100496578  XM_002938123.2  XP_002938169.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.156002 Transcribed sequence with weak similarity to protein more 73.58(n)    BM342227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72361 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    CG72361
    57(a)3
    57.84(n)1
    60.88(a)1
      25F33
    337981  NM_135106.31  NP_608950.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y42A5A.43
    CELE_Y42A5A.41
    Eukaryotic protein kinase domain3
    CELE_Y42A5A.41
    59(a)3
    62.38(n)1
    62.07(a)1
      V(11108095-11109872)3
    1898411  NM_001269361.11  NP_001256290.11 


    ENSEMBL Gene Tree for CDKL1 (if available)
    TreeFam Gene Tree for CDKL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDKL1 gene
    CDK202  CDKL22  CDKL52  CDKL32  CDK72  CDKL42  
    Selected SIMAP similar genes for CDKL1 using alignment to 4 protein entries:     CDKL1_HUMAN (see all proteins) (see all similar genes):
    CDKL2    CDKL4    CDC2    MARK3    CDK3    CDK1
    CDK2    DYRK4    CDKL3    PCTK3    CDK16    DKFZp686L20222
    MAPK7    AURKC    CDK17    PCTK1    MAK    CDK7

    Find genes that share paralogs with CDKL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDKL1 (see all 1496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428309561,2
    --30989928(+) TGAAAA/CTGGAA 1 -- us2k10--------
    rs1822425201,2
    --50796400(+) GGCAAC/TAGAGA 1 -- ds50010--------
    rs115708881,2
    H--50796408(-) TCCTCG/AGATCT 1 -- ds50015Minor allele frequency- A:0.00NS EA 584
    rs115708871,2
    C,F,H--50796495(-) AAAACT/CAGATG 1 -- ds500111Minor allele frequency- C:0.01NS EA 1246
    rs1127482971,2
    F--50796654(+) TGCCAG/CTTGGC 1 -- ds50012Minor allele frequency- C:0.50CSA 4
    rs80079711,2
    C,F,H--50796761(+) TTGATT/GCCTTT 1 -- ut31 trp38Minor allele frequency- G:0.03NS NA WA 1090
    rs128829301,2
    C,H--50796779(+) TCATGT/GCTCCT 1 -- ut31 ese34Minor allele frequency- G:0.00NS EA 420
    rs1440210821,2
    C--50796809(+) AAAACA/GGTAGT 2 R C mis10--------
    rs128816491,2
    H--50796831(+) GTATCA/CCAGTA 2 W C mis1 ese34Minor allele frequency- C:0.00NS EA 420
    rs115708861,2,,4
    C,F,H--50796843(-) AATAAG/TAAGTA 2 K N mis18Minor allele frequency- T:0.01NS EA NA 782

    HapMap Linkage Disequilibrium report for CDKL1 (50796310 - 50883179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDKL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820573CNV Deletion20802225
    esv2657374CNV Deletion23128226
    nsv1272CNV Insertion18451855
    nsv832793CNV Loss17160897
    nsv819725CNV Gain19587683
    esv28926CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603441    OMIM disorders: --


    Find genes that share disorders with CDKL1           About GenesLikeMe

    Genetic Association Database (GAD): CDKL1
    Human Genome Epidemiology (HuGE) Navigator: CDKL1 (1 document)

    Export disorders for CDKL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDKL1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with CDKL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    2. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PubMed id 9000130)1, 2, 9 Taglienti C.A.... Davis R.J. (Oncogene 1996)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    5. The distribution and biochemical properties of a Cdc2-related kinase, KKIALRE, in normal and Alzheimer brains. (PubMed id 7595554)1, 3 Yen S.H....Dickson D.W. (J. Neurochem. 1995)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Evaluation of cyclin-dependent kinase-like 1 expression in breast cancer tissues and its regulation in cancer cell growth. (PubMed id 22804458)1 Tang L....Tang J. (amp 2012)
    8. A role for Cdkl1 in the development of gastric cancer. (PubMed id 22369697)1 Sun W....Wang Q. (Acta Oncol 2012)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8814 HGNC: 1781 AceView: CDKL1 Ensembl:ENSG00000100490 euGenes: HUgn8814
    ECgene: CDKL1 H-InvDB: CDKL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDKL1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkl1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDKL1 gene:
    Search GeneIP for patents involving CDKL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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