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CDK9 Gene

protein-coding   GIFtS: 68
GCID: GC09P130547

Cyclin-Dependent Kinase 9

(Previous name: cyclin-dependent kinase 9 (CDC2-related kinase))
(Previous symbol: CDC2L4)
  See CDK9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 91 2     PITALRE2
CDC2L41 2 3 5     CDC2-Related Kinase2
Cell Division Cycle 2-Like Protein Kinase 42 3     Serine/Threonine Protein Kinase PITALRE2
Cell Division Protein Kinase 92 3     C-2K3
Tat-Associated Kinase Complex Catalytic Subunit2 3     EC 2.7.11.223
TAK2 3     EC 2.7.11.233
Cyclin-Dependent Kinase 9 (CDC2-Related Kinase)1     Serine/Threonine-Protein Kinase PITALRE3
C-2k2     EC 2.7.118
CTK12     

External Ids:    HGNC: 17801   Entrez Gene: 10252   Ensembl: ENSG000001368077   OMIM: 6032515   UniProtKB: P507503   

Export aliases for CDK9 gene to outside databases

Previous GC identifers: GC09P121663 GC09P122194 GC09P124002 GC09P125925 GC09P125926 GC09P127627 GC09P129588


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK9 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important
cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is
an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal
domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its
regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T,
which suggested a possible involvement of this protein in AIDS. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK9 Gene:
CDK9 (cyclin-dependent kinase 9) is a protein-coding gene. Diseases associated with CDK9 include hiv-1. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750
Function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair
(CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the
transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large
subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP
complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF.
Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription
factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in
genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in
cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin
modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and
H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control
co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of
RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the
CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from
replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the
breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of
isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on
'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity
and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The
phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation

summary for CDK9 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK9 (Cyclin-dependent kinase 9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK9 gene promoter:
         PPAR-gamma1   p53   p300   STAT3   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK9 promoter sequence
   Search Chromatin IP Primers for CDK9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.1

CDK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130547:  view genomic region     (about GC identifiers)

Start:
130,547,958 bp from pter      End:
130,553,066 bp from pter
Size:
5,109 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 9  
Size: 372 amino acids; 42778 Da
Subunit: Associates with CCNT1/cyclin-T1, CCNT2/cyclin-T2 (isoform A and isoform B) or CCNK/cyclin-K to form
active P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31 and is part of the super elongation complex (SEC).
Component of a complex which is composed of at least 5 members: HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II,
SUPT5H, and NCL/nucleolin. Associates with UBR5 and forms a transcription regulatory complex composed of CDK9,
RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by
recruiting their promoters. Component of the 7SK snRNP inactive complex which is composed of at least 8 members:
P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, LARP7, BCDIN3, SART3 proteins and 7SK and U6
snRNAs. This inactive 7SK snRNP complex can also interact with NCOR1 and HDAC3, probably to regulate CDK9
acetylation. Release of P-TEFb from P-TEFb/7SK snRNP complex requires both PP2B to transduce calcium Ca(2+)
signaling in response to stimuli (e.g. UV or hexamethylene bisacetamide (HMBA)), and PPP1CA to dephosphorylate
Thr-186. This released P-TEFb remains inactive in the preinitiation complex with BRD4 until new Thr-186
phosphorylation occurs after the synthesis of a short RNA. Interacts with BRD4, probably to target chromatin
binding. Interacts with the acidic/proline-rich region of HIV-1 and HIV-2 Tat via T-loop region, and is thus
required for HIV to hijack host transcription machinery during its replication through cooperative binding to
viral TAR RNA. Interacts with activated nuclear STAT3 and RELA/p65. Binds to AR and MYOD1. Forms a complex
composed of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Isoform 3 binds
to KU70/XRCC6
Miscellaneous: CDK9 inhibition contributes to the anticancer activity of most CDK inhibitors under clinical
investigation (PubMed:18423896 and PubMed:21779453). As a retroviruses target during the hijack of host
transcription (e.g. HIV), CDK9 inhibitors might become specific antiretroviral agents (PubMed:18423896). May be a
target for cardiac hypertrophy future treatments (PubMed:19757441 and PubMed:18423896). May also be a target in
anti-inflammatory therapy in innate immunity and systemic inflammation (PubMed:18728388)
Sequence caution: Sequence=CAI39767.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for CDK9 (see all 19):
1PF6 (3D)        3BLH (3D)        3BLQ (3D)        3BLR (3D)        3LQ5 (3D)        3MI9 (3D)    
Secondary accessions: Q5JU24 Q5JU25 Q5U006 Q96TF1
Alternative splicing: 2 isoforms:  P50750-1   P50750-2   (Contains a phosphoserine at position 27. Contains a phosphoserine at position 52. Contains a phosphothreonine at position 54. Contains a phosphothreonine at position 55. Contains a phosphoserine at position 56. Contains a phosphoserine at position 35)

Explore the universe of human proteins at neXtProt for CDK9: NX_P50750

Explore proteomics data for CDK9 at MOPED

Post-translational modifications: 

  • Autophosphorylation at Thr-186, Ser-347, Thr-350, Ser-353, Thr-354 and Ser-357 triggers kinase activity by
    promoting cyclin and substrate binding (e.g. HIV TAT) upon conformational changes. Thr-186 phosphorylation
    requires the calcium Ca(2+) signaling pathway, including CaMK1D and calmodulin. This inhibition is relieved by
    Thr-29 dephosphorylation. However, phosphorylation at Thr-29 is inhibitory within the HIV transcription
    initiation complex. Phosphorylation at Ser-175 inhibits kinase activity. Can be phosphorylated on either Thr-362
    or Thr-363 but not on both simultaneously (PubMed:18566585)1
  • Dephosphorylation of Thr-186 by PPM1A and PPM1B blocks CDK9 activity and may lead to CDK9 proteasomal degradation.
    However, PPP1CA-mediated Thr-186 dephosphorylation is required to release P-TEFb from its inactive P-TEFb/7SK
    snRNP complex. Dephosphorylation of C-terminus Thr and Ser residues by protein phosphatase-1 (PP1) triggers CDK9
    activity, contributing to the activation of HIV-1 transcription1
  • N6-acetylation of Lys-44 by CBP/p300 promotes kinase activity, whereas acetylation of both Lys-44 and Lys-48
    mediated by PCAF/KAT2B and GCN5/KAT2A reduces kinase activity. The acetylated form associates with PML bodies in
    the nuclear matrix and with the transcriptionally silent HIV-1 genome; deacetylated upon transcription
    stimulation1
  • Polyubiquitinated and thus activated by UBR5. This ubiquitination is promoted by TFIIS/TCEA1 and favors 'Ser-2'
    phosphorylation of RPB1/POLR2A CTD1
  • Ubiquitination2 at Lys3, Lys35, Lys68, Lys164, Lys178, Lys294, Lys345
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CDK9 (P50750)
     LADFGLA  VVTLWYR  DFGLARA 


    See CDK9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001252.1  
    ENSEMBL proteins: 
     ENSP00000395872   ENSP00000362361   ENSP00000362362  
    Reactome Protein details: P50750

    CDK9 Human Recombinant Protein Products:

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    Novus Biologicals CDK9 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CDK9

     
    Search eBioscience for Proteins for CDK9 

    CDK9 Antibody Products:

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    CDK9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK9
    Cloud-Clone Corp. CLIAs for CDK9
    Search eBioscience for ELISAs for CDK9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 9
    CDK9 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P50750

    ProtoNet protein and cluster: P50750

    UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK9_HUMAN, P50750
    Function: Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair
    (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the
    transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large
    subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP
    complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF.
    Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription
    factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in
    genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in
    cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin
    modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and
    H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control
    co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of
    RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the
    CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from
    replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the
    breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of
    isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on
    'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity
    and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The
    phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Enzyme regulation: Inhibited by CDKI-71, CR8, GPC-286199, AG-024322, flavopiridol (alvocidib), RBG-286147,
    anilinopyrimidine 32, arylazopyrazole 31b, indirubin 3'-monoxime, meriolin 3,P276-00, olomoucine II,
    pyrazolotriazine, meriolin, variolin, thiazolyl-pyrimidine, thiazolyl-pyrimidine, indirubin-30-monoxime, ZK
    304709, AG-012986, AT7519, R547, RGB-286638, imidazole pyrimidine, EXEL-3700, EXEL-8647,
    5,6-dichloro-1-b-ribofur-anosyl-benzimidazole (DRB), P276-00, roscovitine (seliciclib, CYC202) and SNS-032
    (BMS-387032). Activation by Thr-186 phosphorylation is calcium Ca(2+) signaling pathway-dependent; actively
    inactivated by dephosphorylation mediated by PPP1CA, PPM1A and PPM1B. Reversibly repressed by acetylation at
    Lys-44 and Lys-48
    Induction: By replication stress, in chromatin. Probably degraded by the proteasome upon Thr-186 dephosphorylation

         Enzyme Numbers (IUBMB): EC 2.7.11.231 EC 2.7.112 EC 2.7.11.221

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16109376
    GO:0003682chromatin binding IEA--
    GO:0004672protein kinase activity TAS8170997
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with CDK9           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK9:
     Abundance of large cells with   Decreased substrate adherent c  Decreased viability  Increased cell death in HCT116 
     Increased circadian period len  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Cdk9 (no phenotypes)

    Find genes that share phenotypes with CDK9           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK9

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK9:
    hsa-mir-193b-3p (MIRT041575), hsa-mir-92a-3p (MIRT049212), hsa-mir-16-5p (MIRT031696), hsa-mir-1 (MIRT000389)

    Block miRNA regulation of human, mouse, rat CDK9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK9 (see all 12):
    hsa-miR-206 hsa-miR-3194-5p hsa-miR-224 hsa-miR-1 hsa-miR-4282 hsa-miR-455-3p hsa-miR-105 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidCDK9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK9

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CDK9 (NM_001261)
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    Addgene plasmids for CDK9 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK9_HUMAN, P50750: Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to
    replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The
    translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008023transcription elongation factor complex TAS10866664

    Find genes that share ontologies with CDK9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK9 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    2Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with CDK9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK9
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway

    1 Cell Signaling Technology (CST) Pathway for CDK9
        Cell Cycle / Checkpoint Control

    2 BioSystems Pathways for CDK9
        MicroRNAs in cardiomyocyte hypertrophy
    IL-6 Signaling Pathway


    Selected Reactome Pathways for CDK9 (see all 12)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Interactions of Tat with host cellular proteins
    Tat-mediated elongation of the HIV-1 transcript


    1 Kegg Pathway  (Kegg details for CDK9):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK9: 
              HIV Host Response in human mouse rat
              Cancer Drug Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK9 (P507501, 2, 3 ENSP000003623614) via UniProtKB, MINT, STRING, and/or I2D (see all 1064)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEXIM1O949921, 2, 3, ENSP000003287734EBI-1383449,EBI-2832510 MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6629577 MINT-7266429 MINT-6629479 MINT-6629547 MINT-6629534 I2D: score=4 STRING: ENSP00000328773
    LARP7Q4G0J31, 2, 3, ENSP000003143114EBI-1383449,EBI-2371923 MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629464 MINT-6629599 MINT-6629479 MINT-6629534 I2D: score=2 STRING: ENSP00000314311
    CCNT1O605631, 2, 3, ENSP000002619004EBI-1383449,EBI-2479671 MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6799506 MINT-15817 MINT-7945693 MINT-6629561 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=6 STRING: ENSP00000261900
    ENSG00000237724P081073, ENSP000004063594I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006282regulation of DNA repair IDA--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with CDK9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK9
    Selected ApexBio Compounds for CDK9 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Compounds for CDK9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK9    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for CDK9    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    Selected Novoseek inferred chemical compound relationships for CDK9 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 88.5 32 19780058 (4), 12622719 (2), 18381438 (1), 17956865 (1) (see all 14)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 81.3 19 15528190 (2), 12622719 (1), 19297489 (1), 18089732 (1) (see all 6)
    roscovitine 77.8 9 17942543 (3), 16969115 (1), 14729633 (1), 20053765 (1) (see all 6)
    hmba 72.5 4 18419522 (2)
    threonine 24.6 6 12185079 (1), 10364292 (1), 19029809 (1), 9003389 (1) (see all 5)
    okadaic acid 21.2 3 16048649 (2)
    atp 19 7 10958691 (2), 12622719 (1), 18566585 (1), 18250157 (1)
    serine 16.3 11 11821989 (2), 12185079 (1), 10364292 (1), 15528190 (1) (see all 7)
    lysine 0 1 18250157 (1)
    nucleoside 0 3 7853496 (1), 10064603 (1)



    Find genes that share compounds with CDK9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CDK9 gene: 
    NM_001261.3  

    Unigene Cluster for CDK9:

    Cyclin-dependent kinase 9
    Hs.150423  [show with all ESTs]
    Unigene Representative Sequence: NM_001261
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421939 ENST00000373264 ENST00000480353 ENST00000491521 ENST00000498339
    ENST00000373265(uc004bse.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat CDK9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK9 (see all 12):
    hsa-miR-206 hsa-miR-3194-5p hsa-miR-224 hsa-miR-1 hsa-miR-4282 hsa-miR-455-3p hsa-miR-105 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidCDK9 3' UTR sequence
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK9 (NM_001261)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK9
    Addgene plasmids for CDK9 
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      QuantiTect SYBR Green Assays in human, mouse, rat CDK9
      QuantiFast Probe-based Assays in human, mouse, rat CDK9

    Additional mRNA sequence: 

    AB451289.1 AB451421.1 AK313828.1 BC001968.1 BT019903.1 L25676.1 X80230.1 

    11 DOTS entries:

    DT.452362  DT.100789476  DT.307654  DT.100789477  DT.100789481  DT.121165964  DT.86841566  DT.91757353 
    DT.100789475  DT.91680010  DT.95191814 

    Selected AceView cDNA sequences (see all 407):

    CR589995 CD619492 CR619508 BM676179 BE207410 BM796579 AI536944 M98045 
    BM975796 BI836452 BQ436563 AA298722 CR620207 BF916661 BM468258 AW301211 
    BE378662 BE302497 BG014232 AI932218 BC007121 BQ068950 BU854910 BQ930310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTAGGAGG
    CDK9 Expression
    About this image


    CDK9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CDK9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150423

    UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK9: 
              HIV Host Response in human mouse rat
              Cancer Drug Targets in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CDK9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK9 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk91 , 5 cyclin-dependent kinase 9 (CDC2-related kinase)1, 5 89.25(n)1
    98.66(a)1
      2 (22.09 cM)5
    1079511  NM_130860.31  NP_570930.11 
     327057845 
    chicken
    (Gallus gallus)
    Aves CDK91 cyclin-dependent kinase 9 82.97(n)
    93.01(a)
      417226  NM_001006201.2  NP_001006201.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK96
    cyclin-dependent kinase 9
    90(a)
    1 ↔ 1
    GL344184.1(60128-63551)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdk9-prov2 cyclin-dependent kinase 9 (CDC2-related kinase) 78.56(n)    BC045247.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055634.12   -- 80.75(n)    BC055634.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk91 , 3 RNA elongation from Pol II promoter
    protein serine/threonine more3
    Cyclin-dependent kinase 91
    73(a)3
    68.25(n)1
    74.02(a)1
      58F33
    375861  NM_057878.31  NP_477226.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-91 cdk-9 55.15(n)
    57.02(a)
      173023  NM_060505.3  NP_492906.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGV1(YPR161C)4 Cyclin (Bur2p)-dependent protein kinase that functions more   --   16(866422-864449) 856290  NP_015487.1 
    rice
    (Oryza sativa)
    Liliopsida Os.144732 Oryza sativa mRNA for cyclin-dependent kinase C (CDKC1 more 73.7(n)    AJ564977.1 


    ENSEMBL Gene Tree for CDK9 (if available)
    TreeFam Gene Tree for CDK9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK9 gene
    CDK11A2  CDK122  CDK102  CDK132  CDK11B2  
    Selected SIMAP similar genes for CDK9 using alignment to 2 protein entries:     CDK9_HUMAN (see all proteins) (see all similar genes):
    CDC2L1    CDC2L2    CDK11A    CDK11B    CDK12    CDC2
    CDK20    CDK3    CDK6    CDK1    DKFZp686L20222    CDK17
    CDK5    CDK15    PCTK1    CDK10    CDK16    CDK14

    Find genes that share paralogs with CDK9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK9 (see all 188)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs625871861,2
    F--130548826(+) AGACAG/CGCTGC 1 -- int11Minor allele frequency- C:0.50NA 2
    rs1407018251,2
    --130548855(+) CGTGCA/CCTGGG 1 -- int10--------
    rs2005892131,2
    C--130548953(+) ATGAGC/TTCTCG 1 -- int10--------
    rs2001272011,2
    C--130548957(+) GTTCTC/TGGGTC 1 -- int10--------
    rs2018628361,2
    C--130548972(+) TTTCCA/G/TCCTGC 1 -- int10--------
    rs32177341,2
    C,F--130549077(+) ATCGGG/ACGTGC 1 -- int12Minor allele frequency- A:0.00NS EU 1293
    rs1510876571,2
    --130549210(+) ACCCTA/GAAACT 1 -- int10--------
    rs1832674771,2
    C--130549233(+) CTTAGA/GCAGTT 1 -- int10--------
    rs1410701461,2
    --130549297(+) ACGAAA/GTTAGG 1 -- int10--------
    rs1502460911,2
    --130549352(+) AAAAGA/GAAGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CDK9 (130547958 - 130553066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK9 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv466576CNV Loss19166990
    dgv8288n71CNV Loss21882294
    nsv893868CNV Loss21882294
    nsv893865CNV Loss21882294
    nsv466573CNV Loss19166990
    nsv471323CNV Loss18288195
    nsv893867CNV Loss21882294
    dgv8287n71CNV Loss21882294
    nsv466575CNV Loss19166990
    nsv893874CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK9
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603251    OMIM disorders: --

    UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750
  • Note=Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy, and
    confers predisposition to heart failure

  • 1 disease for CDK9:    
    About MalaCards
    hiv-1


    Find genes that share disorders with CDK9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDK9 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 68.1 34 11572868 (2), 9557739 (2), 18971272 (2), 10958691 (2) (see all 24)
    equine infectious anemia 60 1 7853496 (1)
    cardiac hypertrophy 51.1 4 19757441 (3), 16720337 (1)
    retinoblastoma 44.8 8 8170997 (3), 17064068 (1), 8870681 (1), 9003389 (1)
    promyelocytic leukemia 18.3 2 16306619 (1)
    leukemia 9.38 3 11152495 (1), 12386808 (1)
    herpes simplex 4.45 1 15890914 (1)
    necrosis 0 3 15528190 (1), 11689614 (1)
    aids 0 7 10536359 (1), 12432243 (1), 10092203 (1), 17251582 (1) (see all 5)
    hiv infections 0 1 10903437 (1)


    Export disorders for CDK9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK9 gene, integrated from 10 sources (see all 446):
    (articles sorted by number of sources associating them with CDK9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. (PubMed id 8170997)1, 2, 3, 9 Grana X.... Giordano A. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. (PubMed id 10958691)1, 2, 9 Garber M.E....Jones K.A. (Mol. Cell. Biol. 2000)
    3. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. (PubMed id 20081228)1, 2, 9 Sunagawa Y.... Hasegawa K. (J. Biol. Chem. 2010)
    4. Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. (PubMed id 19844166)1, 2, 9 Pirngruber J.... Johnsen S.A. (Cell Cycle 2009)
    5. Acetylation of conserved lysines in the catalytic core of cyclin- dependent kinase 9 inhibits kinase activity and regulates transcription. (PubMed id 18250157)1, 2, 9 Sabo A.... Giacca M. (Mol. Cell. Biol. 2008)
    6. Regulation of P-TEFb elongation complex activity by CDK9 acetylation. (PubMed id 17452463)1, 2, 9 Fu J.... Wong J. (Mol. Cell. Biol. 2007)
    7. TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. (PubMed id 9356449)1, 3, 9 Yang X....Herrmann C.H. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    8. CDK9 directs H2B monoubiquitination and controls replication- dependent histone mRNA 3'-end processing. (PubMed id 19575011)1, 2, 9 Pirngruber J.... Johnsen S.A. (EMBO Rep. 2009)
    9. The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. (PubMed id 17956865)1, 2, 9 Hou T.... Brasier A.R. (J. Biol. Chem. 2007)
    10. Genomic organization and characterization of promoter function of the human CDK9 gene. (PubMed id 10903437)1, 2, 9 Liu H. and Rice A.P. (Gene 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1025 HGNC: 1780 AceView: CDK9andFPGS Ensembl:ENSG00000136807 euGenes: HUgn1025
    ECgene: CDK9 Kegg: 1025 H-InvDB: CDK9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK9 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK9 gene:
    Search GeneIP for patents involving CDK9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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