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CDK8 Gene

protein-coding   GIFtS: 68
GCID: GC13P026828

Cyclin-Dependent Kinase 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 81 2     K352
Cell Division Protein Kinase 82 3     CDK8 Protein Kinase2
Mediator Complex Subunit CDK82 3     EC 2.7.11.223
Mediator Of RNA Polymerase II Transcription Subunit CDK82 3     EC 2.7.11.233
Protein Kinase K352 3     EC 2.7.118

External Ids:    HGNC: 17791   Entrez Gene: 10242   Ensembl: ENSG000001329647   OMIM: 6031845   UniProtKB: P493363   

Export aliases for CDK8 gene to outside databases

Previous GC identifers: GC13P024808 GC13P020808 GC13P025758 GC13P024626 GC13P025726 GC13P007646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK8 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit
cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal
domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate
transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH),
thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDK8 Gene:
CDK8 (cyclin-dependent kinase 8) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase activity. An important paralog of this gene is CDK19.

UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD
(C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a
transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and
transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular
domain of NOTCH, leading to its degradation

Gene Wiki entry for CDK8 (Cyclin-dependent kinase 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK8 gene promoter:
         Nkx3-1 v2   Nkx3-1   TBP   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK8 promoter sequence
   Search Chromatin IP Primers for CDK8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12

CDK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P026828:  view genomic region     (about GC identifiers)

Start:
26,828,276 bp from pter      End:
26,979,375 bp from pter
Size:
151,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 8  
Size: 464 amino acids; 53284 Da
Cofactor: Magnesium (By similarity)
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed
by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1
Selected PDB 3D structures from and Proteopedia for CDK8 (see all 10):
3RGF (3D)        4F6S (3D)        4F6U (3D)        4F6W (3D)        4F70 (3D)        4F7J (3D)    
Secondary accessions: Q5VUF3 Q6ISB5
Alternative splicing: 2 isoforms:  P49336-1   P49336-2   

Explore the universe of human proteins at neXtProt for CDK8: NX_P49336

Explore proteomics data for CDK8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for CDK8 (P49336)
     VLHRDLK  YRAPELLL 


    See CDK8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001251.1  
    ENSEMBL proteins: 
     ENSP00000370938   ENSP00000437696  
    Reactome Protein details: P49336

    CDK8 Human Recombinant Protein Products:

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    Novus Biologicals CDK8 Protein
    Novus Biologicals CDK8 Lysate
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    Cloud-Clone Corp. Proteins for CDK8

     
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    antibodies-online peptides for CDK8

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    CDK8 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 8
    CDK8 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49336

    ProtoNet protein and cluster: P49336

    UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK8_HUMAN, P49336
    Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD
    (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a
    transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and
    transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular
    domain of NOTCH, leading to its degradation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate

         Enzyme Numbers (IUBMB): EC 2.7.11.231 EC 2.7.112 EC 2.7.11.221

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS7568034
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15546612
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDK8           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK8:
     Decreased substrate adherent c  Decreased viability  Increased S DNA content  Increased apoptosis 
     Paclitaxel antagonistic effect  Reduced beta-catenin activity  

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdk8):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with CDK8           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDK8

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK8:
    hsa-mir-193b-3p (MIRT041203), hsa-mir-10a-5p (MIRT047736), hsa-mir-26a-5p (MIRT001021)

    Block miRNA regulation of human, mouse, rat CDK8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK8 (see all 29):
    hsa-miR-562 hsa-miR-181c hsa-miR-148b hsa-miR-513a-5p hsa-miR-548v hsa-let-7a-2* hsa-miR-1297 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidCDK8 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CDK8 (NM_001260)
    Sino Biological Human cDNA Clone for CDK8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK8
    Addgene plasmids for CDK8 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK8_HUMAN, P49336: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA14638676

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK8 About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with CDK8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CDK8
        Notch Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK8
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway

    1 Cell Signaling Technology (CST) Pathway for CDK8
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CDK8
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for CDK8
        SREBP signalling

    1 Sino Biological Pathway for CDK8
        Notch Signaling Pathway

    Selected Reactome Pathways for CDK8 (see all 7)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK8: 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK8 (P493361, 2, 3 ENSP000003709384) via UniProtKB, MINT, STRING, and/or I2D (see all 338)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156482, 3, ENSP000003006514MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000300651
    CCNCP248631, 3, ENSP000003582224EBI-394377,EBI-395261 I2D: score=13 STRING: ENSP00000358222
    MED23Q9ULK42, 3, ENSP000003570474MINT-6744763 I2D: score=1 STRING: ENSP00000357047
    MED15Q96RN52, 3, ENSP000002632054MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000263205
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006468protein phosphorylation ----
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK8

    3 HMDB Compounds for CDK8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CDK8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    1 Novoseek inferred chemical compound relationship for CDK8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 16.4 2 9061953 (1), 15979093 (1)



    Find genes that share compounds with CDK8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK8 gene: 
    NM_001260.1  

    Unigene Cluster for CDK8:

    Cyclin-dependent kinase 8
    Hs.382306  [show with all ESTs]
    Unigene Representative Sequence: BC094784
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381527(uc001uqr.1 uc001uqs.1 uc001uqt.1) ENST00000477290
    ENST00000465820 ENST00000477277 ENST00000480323 ENST00000536792
    miRNA
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    hsa-miR-562 hsa-miR-181c hsa-miR-148b hsa-miR-513a-5p hsa-miR-548v hsa-let-7a-2* hsa-miR-1297 hsa-miR-103a
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK8
      QuantiTect SYBR Green Assays in human, mouse, rat CDK8
      QuantiFast Probe-based Assays in human, mouse, rat CDK8

    Additional mRNA sequence: 

    AK296084.1 AK296875.1 AY702976.1 BC069634.1 BC094784.1 BC104492.1 BC105950.1 BC107601.1 
    L23208.1 X85753.1 

    8 DOTS entries:

    DT.412995  DT.99983284  DT.91760978  DT.100637351  DT.120766387  DT.99943556  DT.100755398  DT.120766360 

    Selected AceView cDNA sequences (see all 85):

    BX283603 AI655208 AL535088 BC069634 BU684628 CR623449 AI205974 AA782285 
    CD108297 CN483693 CK904283 AW043913 BX281838 L13827 BE694070 AW470057 
    BE467537 L13825 BX436945 BQ428930 AI375103 BQ022018 AI701838 BF669282 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDK8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                -                                                               


    ECgene alternative splicing isoforms for CDK8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGACACAA
    CDK8 Expression
    About this image

    CDK8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.382306
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK8: 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK8 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk81 , 5 cyclin-dependent kinase 81, 5 93.97(n)1
    98.92(a)1
      5 (85.19 cM)5
    2640641  NM_153599.31  NP_705827.21 
     1462312305 
    chicken
    (Gallus gallus)
    Aves CDK81 cyclin-dependent kinase 8 91.72(n)
    98.06(a)
      428080  XM_004938783.1  XP_004938840.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK86
    cyclin-dependent kinase 8
    100(a)
    1 ↔ 1
    GL343306.1(727404-773217)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC762042 hypothetical protein MGC76204 85.29(n)    BC063921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk82 cyclin-dependent kinase 8 80.21(n)   373868  AY007219.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk81 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Cyclin-dependent kinase 81
    84(a)3
    69.58(n)1
    85.25(a)1
      67C103
    391571  NM_080487.31  NP_536735.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-81 cdk-8 62.99(n)
    63.36(a)
      172677  NM_059956.6  NP_492357.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN3(YPL042C)4 Cyclin-dependent protein kinase, component of RNA polymerase more   --   16(474707-473040) 856065  NP_015283.1 
    rice
    (Oryza sativa)
    Liliopsida Os.29892 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.96(n)    AK066824.1 


    ENSEMBL Gene Tree for CDK8 (if available)
    TreeFam Gene Tree for CDK8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK8 gene
    CDK192  
    Selected SIMAP similar genes for CDK8 using alignment to 4 protein entries:     CDK8_HUMAN (see all proteins) (see all similar genes):
    CDK19    DKFZp434M058    CDC2L1    STK36    CDK3    CDC2L2
    CDK11A    CDK11B    CDK2    CDK4    CDK16    CDK10
    CDK5    CDK1    CDC2    CDK17    CDK6    DKFZp686L20222

    Find genes that share paralogs with CDK8           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CDK8
    PGOHUM00000239978 PGOHUM00000240869


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK8 (see all 3070)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419804
    A lung neuroendocrine carcinoma sample4--see VAR_0419802 D N mis40--------
    VAR_0419814
    A colorectal adenocarcinoma sample4--see VAR_0419812 R C mis40--------
    rs350874221,2
    C--7865655(+) AGTAA-/ACACATG 1 -- int10--------
    rs1425080951,2
    C--26826800(+) AAAGCC/TTACAT 1 -- int10--------
    rs79975241,2
    C,F--26826867(+) GTAAAT/CGACAA 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1471506841,2
    C--26826916(+) TTATAC/TAGTAT 1 -- int10--------
    rs1162190121,2
    C,F--26826923(+) GTATGC/TTAGGT 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1403065051,2
    --26826964(+) GTCACA/TAATTT 1 -- int10--------
    rs80022261,2
    C,F,A,H--26827054(+) ATGGAT/ACTTTT 1 -- int124Minor allele frequency- A:0.16NA NS EA WA 2516
    rs764282061,2
    F--26827135(+) CTAGGT/ATTTAC 1 -- int11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for CDK8 (26828276 - 26979375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268548CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK8
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603184    OMIM disorders: --


    Find genes that share disorders with CDK8           About GenesLikeMe

    1 Novoseek inferred disease relationship for CDK8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 20514474 (3), 20454513 (1), 20098423 (1), 16969500 (1) (see all 5)

    Genetic Association Database (GAD): CDK8
    Human Genome Epidemiology (HuGE) Navigator: CDK8 (2 documents)

    Export disorders for CDK8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK8 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with CDK8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. (PubMed id 7568034)1, 2, 3, 9 Tassan J.-P.... Nigg E.A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. (PubMed id 15546612)1, 2, 9 Fryer C.J.... Jones K.A. (Mol. Cell 2004)
    3. The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. (PubMed id 21806996)1, 2 Schneider E.V....Maskos K. (J. Mol. Biol. 2011)
    4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    6. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (Nature 2000)
    7. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (Mol. Cell 1999)
    8. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (Mol. Cell 1998)
    9. Role of CDK8 and beta-catenin in colorectal adenocarcinoma. (PubMed id 20514474)1, 9 Seo J.O....Lim S.C. (Oncol. Rep. 2010)
    10. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. (PubMed id 19790197)1, 9 Firestein R....Ogino S. (Int. J. Cancer 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1024 HGNC: 1779 AceView: CDK8 Ensembl:ENSG00000132964 euGenes: HUgn1024
    ECgene: CDK8 H-InvDB: CDK8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK8 gene:
    Search GeneIP for patents involving CDK8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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