CDK8 Gene
protein-coding GIFtS: 67
GCID: GC13P026828
|
|
cyclin-dependent kinase 8
| |
Aliases
for CDK8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin-Dependent Kinase 81 2 | | Protein Kinase K352 3 | | K351 2 | | CDK8 Protein Kinase2 | | Cell Division Protein Kinase 82 3 | | EC 2.7.11.223 | | Mediator Complex Subunit CDK82 3 | | EC 2.7.11.233 | | Mediator Of RNA Polymerase II Transcription Subunit CDK82 3 | | EC 2.7.118 |
Export aliases for CDK8 gene to outside databasesPrevious GC identifers: GC13P024808 GC13P020808 GC13P025758 GC13P024626 GC13P025726 GC13P007646 |
Summaries
for CDK8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDK8:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family membersare highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and areknown to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C arecomponents of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of thelargest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting theCDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the'Mediator-like' protein complexes and the basal transcription machinery. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the largesubunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited throughinteraction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation
Gene Wiki entry for CDK8 (Cyclin-dependent kinase 8)
|
Genomic Views
for CDK8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDK8 gene promoter:
Nkx3-1 v2 Nkx3-1 TBP Nkx3-1 v3 Nkx3-1 v1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDK8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.13 HGNC cytogenetic band: 13q12CDK8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P026828: view genomic region
(about GC identifiers)
Start:
|
26,828,276 bp from pter |
End:
|
26,979,375 bp from pter |
Size:
|
151,100 bases |
Orientation:
|
plus strand |
|
Proteins
for CDK8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336 (See
protein sequence)Recommended Name: Cyclin-dependent kinase 8 Size: 464 amino acids; 53284 Da
Cofactor: Magnesium (By similarity)
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinctmodule termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module insupporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinctsubunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 alsoassociates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from  and Proteopedia  for CDK8:3RGF (3D)
Secondary accessions: Q5VUF3 Q6ISB5Alternative splicing: 2 isoforms: P49336-1 P49336-2 Explore the universe of human proteins at neXtProt for CDK8: NX_P49336
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49336
2 DME Specific Peptides for CDK8 (P49336)
CDK8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001251.1
ENSEMBL proteins: ENSP00000370938 ENSP00000437696 Reactome Protein details: P49336
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CDK8 for ontologies About GeneDecksing
CDK8 Antibody Products:
Assay Products for CDK8: |
Protein
Domains /
Families
for CDK8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDK8 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49336ProtoNet protein and cluster: P49336 UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CDK8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the largesubunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited throughinteraction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradationCatalytic activity: ATP + a protein = ADP + a phosphoproteinCatalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphateEnzyme Numbers (IUBMB): EC 2.7.11.231 EC 2.7.112 EC 2.7.11.221
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDK8 (NM_001260) | |  | Sino Biological Human cDNA Clone for CDK8 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK8 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CDK8 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for CDK8:
Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cdk8):
CDK8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CDK8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 3 | Generic Transcription Pathway | | | 4 | HIV Infection | | | 5 | Cell Cycle / Checkpoint Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CDK8
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK8
1 
Cell Signaling Technology (CST) Pathway for CDK8
1  GeneGo (Thomson Reuters) Pathway for CDK8
5/20 
Reactome Pathways for CDK8 (see all 20)
CDK8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/197 Interacting proteins for CDK8 (P493361, 2, 3 ENSP000003709384) via UniProtKB, MINT, STRING, and/or I2D (see all 197)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MED1 | Q156482, 3, ENSP000003006514 | MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D:
score=1 STRING: ENSP00000300651 | | MED15 | Q96RN52, 3, ENSP000002632054 | MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D:
score=1 STRING: ENSP00000263205 | | CCNC | P248631, 3, ENSP000003582224 | EBI-394377,EBI-395261 I2D:
score=13 STRING: ENSP00000358222 | | MED14 | O602442, 3, ENSP000003237204 | MINT-6744763 I2D:
score=1 STRING: ENSP00000323720 | | TRRAP | Q9Y4A52, 3, ENSP000003477334 | MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 I2D:
score=1 STRING: ENSP00000347733 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0006468 | protein phosphorylation |
-- | -- | | GO:0007179 | transforming growth factor beta receptor signaling pathway |
TAS | -- |
CDK8 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDK8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDK8 for compounds About GeneDecksing
 Browse Tocris compounds for CDK8
3 HMDB Compounds for CDK8 About this table
1 DrugBank Compound for CDK8 About this table
1 Novoseek chemical compound relationship for CDK8 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
16.4 |
2 |
9061953 (1), 15979093 (1) |
Search CenterWatch for drugs/clinical trials and news about CDK8
|
Transcripts
for CDK8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDK8 gene: NM_001260.1 Unigene Cluster for CDK8: Cyclin-dependent kinase 8 Hs.382306 [show with all ESTs]Unigene Representative Sequence: BC0947846 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381527(uc001uqr.1 uc001uqs.1 uc001uqt.1) ENST00000477290
ENST00000465820 ENST00000477277 ENST00000480323 ENST00000536792
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDK8 (NM_001260) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK8 |
Additional cDNA sequence: AK296084.1 AK296875.1 AY702976.1 BC069634.1 BC094784.1 BC104492.1 BC105950.1 BC107601.1 L23208.1 X85753.1 8 DOTS entries: DT.412995 DT.99983284 DT.91760978 DT.100637351 DT.120766387 DT.99943556 DT.100755398 DT.120766360 24/85 AceView cDNA sequences (see all 85): CN483693 AL535088 AW043913 AI655208 L13827 AW470057 BE467537 BX281838 BC069634 CD108297 BU684628 L13825 BE694070 BX283603 CR623449 CK904283 AA782285 AI205974 BQ428930 NM_001260 L23208 AA758002 CF593892 BF669282
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CDK8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDK8
|
Expression
for CDK8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDK8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGACACAA
About this image
See CDK8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK8
SOURCE GeneReport for Unigene cluster: Hs.382306
SABiosciences Expression via Pathway-Focused PCR Arrays including CDK8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK8 |
Orthologs
for CDK8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CDK8 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDK81 |
cyclin-dependent kinase 8 |
92.24(n)
98.71(a) |
|
428080 XM_425638.3 XP_425638.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CDK86 |
-- |
100(a) |
1 ↔ 1 |
GL343306.1(727404-771934) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
MGC762042 |
hypothetical protein MGC76204 |
85.29(n) |
|
BC063921.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cdk82 |
cyclin-dependent kinase 8 |
80.21(n) |
|
373868 AY007219.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cdk81 , 3 |
protein amino acid phosphorylation protein
serine/threonine more3
Cyclin-dependent kinase 81 |
84(a)3
69.58(n)1
84.88(a)1 |
|
67C103
391571 NM_080487.21 NP_536735.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
cdk-81 |
Protein CDK-8 |
62.67(n)
62.67(a) |
|
172677 NM_059956.5 NP_492357.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HEN36 |
cyclin-dependent kinase E-1 |
34(a) |
1 → many |
5(25463437-25465897) |
rice
(Oryza sativa) |
Liliopsida |
Os.29892 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
71.96(n) |
|
AK066824.1 |
ENSEMBL Gene Tree for CDK8 (if available)
TreeFam Gene Tree for CDK8 (if available) |
Paralogs
for CDK8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDK8 gene
- CDK192
18/23 SIMAP similar genes for CDK8 using alignment to 3 protein entries: CDK8_HUMAN (see all proteins)
(see all similar genes):CDK19 DKFZp434M058 CDC2L1 STK36 CDK11B CDK10
CDK3 CDC2L2 CDK11A CDK2 CDK4 CDK16
CDK5 CDK1 CDC2 CDK17 CDK6 DKFZp686L20222
CDK8 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CDK8
PGOHUM00000239978 PGOHUM00000240869
|
Genomic Variants
for CDK8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDK8 (26828276 - 26979375 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDK8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK8 |
|
Disorders
/ Diseases
for CDK8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDK8 for disorders About GeneDecksing
OMIM gene information: 603184
OMIM disorders: --
17  diseases for CDK8: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma gastric adenocarcinoma hermaphroditism
noma esophagitis colorectal cancer lung cancer
adenocarcinoma sarcoma carcinoma cholesterol
immunodeficiency thyroiditis melanoma malaria
neuronitis
1 Novoseek disease relationship for CDK8 gene About this table
Human Genome Epidemiology (HuGE) Navigator: CDK8 (2 documents)
Export disorders for CDK8 gene to outside databases
|
Publications
for CDK8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDK8 gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with CDK8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. (PubMed id 7568034)1, 2, 3, 9 Tassan J.-P.... Nigg E.A. (1995)
- Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. (PubMed id 15546612)1, 2, 9 Fryer C.J.... Jones K.A. (2004)
- The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. (PubMed id 21806996)1, 2 Schneider E.V....Maskos K. (2011)
- MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
- TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (2000)
- A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (1999)
- NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (1998)
- Role of CDK8 and beta-catenin in colorectal adenocarc inoma. (PubMed id 20514474)1, 9 Seo J.O....Lim S.C. (2010)
- CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. (PubMed id 19790197)1, 9 Firestein R....Ogino S. (2010)
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External Searches for CDK8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CDK8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CDK8 gene
(According to HUGE)
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Specialized Databases showing CDK8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for CDK8 gene:
Search GeneIP for patents involving CDK8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CDK8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDK8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK8 | | | OriGene Protein Over-expression Lysate for CDK8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDK8 | | OriGene 3'-UTR Clone for CDK8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CDK8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDK8 | | OriGene Custom Protein Services for CDK8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK8 |
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| | Antibodies & Assays for CDK8 |
| | | | Search Tocris compounds for CDK8 |
| |  |  |  |  | | | | | | Recombinant Protein for CDK8 |
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 | | | CDK8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK8 |
|  |  |  | | | | ThermoFisher Antibodies for CDK8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK8 |
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