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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK8 Gene

protein-coding   GIFtS: 71
GCID: GC13P026828

Cyclin-Dependent Kinase 8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 81 2     K352
Cell Division Protein Kinase 82 3     CDK8 Protein Kinase2
Mediator Complex Subunit CDK82 3     EC 2.7.11.223
Mediator Of RNA Polymerase II Transcription Subunit CDK82 3     EC 2.7.11.233
Protein Kinase K352 3     EC 2.7.118

External Ids:    HGNC: 17791   Entrez Gene: 10242   Ensembl: ENSG000001329647   OMIM: 6031845   UniProtKB: P493363   

Export aliases for CDK8 gene to outside databases

Previous GC identifers: GC13P024808 GC13P020808 GC13P025758 GC13P024626 GC13P025726 GC13P007646


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK8 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit
cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal
domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate
transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH),
thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDK8 Gene: 
CDK8 (cyclin-dependent kinase 8) is a protein-coding gene. Diseases associated with CDK8 include noma, and gastric adenocarcinoma, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase activity. An important paralog of this gene is CDK19.

UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD
(C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a
transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and
transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular
domain of NOTCH, leading to its degradation

Gene Wiki entry for CDK8 (Cyclin-dependent kinase 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK8 gene promoter:
         Nkx3-1 v2   Nkx3-1   TBP   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12

CDK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P026828:  view genomic region     (about GC identifiers)

Start:
26,828,276 bp from pter      End:
26,979,375 bp from pter
Size:
151,100 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 8  
Size: 464 amino acids; 53284 Da
Cofactor: Magnesium (By similarity)
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed
by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1
Subcellular location: Nucleus (Probable)
6/10 PDB 3D structures from and Proteopedia for CDK8 (see all 10):
3RGF (3D)        4F6S (3D)        4F6U (3D)        4F6W (3D)        4F70 (3D)        4F7J (3D)    
Secondary accessions: Q5VUF3 Q6ISB5
Alternative splicing: 2 isoforms:  P49336-1   P49336-2   

Explore the universe of human proteins at neXtProt for CDK8: NX_P49336

Explore proteomics data for CDK8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49336

  • 2 DME Specific Peptides for CDK8 (P49336)
     VLHRDLK  YRAPELLL 

    CDK8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK8 Protein Expression
    REFSEQ proteins: NP_001251.1  
    ENSEMBL proteins: 
     ENSP00000370938   ENSP00000437696  
    Reactome Protein details: P49336
    Human Recombinant Protein Products for CDK8: 
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    Novus Biologicals CDK8 Protein
    Novus Biologicals CDK8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CDK8
    Cloud-Clone Corp. Proteins for CDK8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA14638676

    CDK8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 8 
    CDK8 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49336

    ProtoNet protein and cluster: P49336

    UniProtKB/Swiss-Prot: CDK8_HUMAN, P49336
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK8_HUMAN, P49336
    Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD
    (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a
    transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and
    transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular
    domain of NOTCH, leading to its degradation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate

         Enzyme Numbers (IUBMB): EC 2.7.11.231 EC 2.7.112 EC 2.7.11.221

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS7568034
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15546612
    GO:0005524ATP binding IEA--
         
    CDK8 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK8:
     Decreased substrate adherent c  Decreased viability  Increased S DNA content  Increased apoptosis 
     Paclitaxel antagonistic effect  Reduced beta-catenin activity  

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdk8):
     embryogenesis  mortality/aging 

    CDK8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK8 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK8 
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    miRNA
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    hsa-mir-26a (MIRT001021)

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    hsa-miR-562 hsa-miR-181c hsa-miR-148b hsa-miR-513a-5p hsa-miR-548v hsa-let-7a-2* hsa-miR-1297 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidCDK8 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK8 About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74
    2Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    3Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    4Axon guidance
    Developmental Biology0.69
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CDK8
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 R&D Systems Pathway for CDK8
        Notch Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK8
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway

    1 Cell Signaling Technology (CST) Pathway for CDK8
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CDK8
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for CDK8
        SREBP signalling

    1 Sino Biological Pathway for CDK8 
        Notch Signaling Pathway

    5/20        Reactome Pathways for CDK8 (see all 20)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    FBXW7 Mutants and NOTCH1 in Cancer



    CDK8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/206 Interacting proteins for CDK8 (P493361, 2, 3 ENSP000003709384) via UniProtKB, MINT, STRING, and/or I2D (see all 206)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156482, 3, ENSP000003006514MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000300651
    MED15Q96RN52, 3, ENSP000002632054MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000263205
    CCNCP248631, 3, ENSP000003582224EBI-394377,EBI-395261 I2D: score=13 STRING: ENSP00000358222
    MED14O602442, 3, ENSP000003237204MINT-6744763 I2D: score=1 STRING: ENSP00000323720
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006468protein phosphorylation ----
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--

    CDK8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK8 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK8:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK8

    3 HMDB Compounds for CDK8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CDK8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    1 Novoseek inferred chemical compound relationship for CDK8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 16.4 2 9061953 (1), 15979093 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK8 gene: 
    NM_001260.1  

    Unigene Cluster for CDK8:

    Cyclin-dependent kinase 8
    Hs.382306  [show with all ESTs]
    Unigene Representative Sequence: BC094784
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381527(uc001uqr.1 uc001uqs.1 uc001uqt.1) ENST00000477290
    ENST00000465820 ENST00000477277 ENST00000480323 ENST00000536792
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK8 (see all 29):
    hsa-miR-562 hsa-miR-181c hsa-miR-148b hsa-miR-513a-5p hsa-miR-548v hsa-let-7a-2* hsa-miR-1297 hsa-miR-103a
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK8

    Additional mRNA sequence: 

    AK296084.1 AK296875.1 AY702976.1 BC069634.1 BC094784.1 BC104492.1 BC105950.1 BC107601.1 
    L23208.1 X85753.1 

    8 DOTS entries:

    DT.412995  DT.99983284  DT.91760978  DT.100637351  DT.120766387  DT.99943556  DT.100755398  DT.120766360 

    24/85 AceView cDNA sequences (see all 85):

    CR623449 AA782285 BX283603 CD108297 BC069634 CN483693 AW043913 L13827 
    CK904283 AW470057 AI205974 BU684628 AI655208 BE467537 L13825 AL535088 
    BX281838 BE694070 L23311 BQ022018 AI702778 BQ428930 BF669282 AA678409 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDK8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                -                                                               


    ECgene alternative splicing isoforms for CDK8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGACACAA
    CDK8 Expression
    About this image


    See CDK8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK8

    SOURCE GeneReport for Unigene cluster: Hs.382306
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK8: 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK8 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk81 , 5 cyclin-dependent kinase 81, 5 93.97(n)1
    98.92(a)1
      5 (85.19 cM)5
    2640641  NM_153599.31  NP_705827.21 
     1462312305 
    chicken
    (Gallus gallus)
    Aves CDK81 cyclin-dependent kinase 8 92.24(n)
    98.71(a)
      428080  XM_425638.3  XP_425638.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDK86
    Uncharacterized protein
    100(a)
    1 ↔ 1
    GL343306.1(727404-773217)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC762042 hypothetical protein MGC76204 85.29(n)    BC063921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk82 cyclin-dependent kinase 8 80.21(n)   373868  AY007219.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk81 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Cyclin-dependent kinase 81
    84(a)3
    69.58(n)1
    84.88(a)1
      67C103
    391571  NM_080487.21  NP_536735.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-81 Protein CDK-8 62.67(n)
    62.67(a)
      172677  NM_059956.5  NP_492357.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN3(YPL042C)4 Cyclin-dependent protein kinase, component of RNA polymerase more   --   16(474707-473040) 856065  NP_015283.1 
    rice
    (Oryza sativa)
    Liliopsida Os.29892 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.96(n)    AK066824.1 


    ENSEMBL Gene Tree for CDK8 (if available)
    TreeFam Gene Tree for CDK8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK8 gene
    CDK192  
    18/24 SIMAP similar genes for CDK8 using alignment to 3 protein entries:     CDK8_HUMAN (see all proteins) (see all similar genes):
    CDK19    DKFZp434M058    CDC2L1    STK36    CDK11B    CDK10
    CDK3    CDC2L2    CDK11A    CDK2    CDK4    CDK16
    CDK5    CDK1    CDC2    CDK17    CDK6    DKFZp686L20222

    CDK8 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CDK8
    PGOHUM00000239978 PGOHUM00000240869


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3070 SNPs in CDK8 are shown (see all 3070)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419804
    A lung neuroendocrine carcinoma sample4--see VAR_0419802 D N mis40--------
    VAR_0419814
    A colorectal adenocarcinoma sample4--see VAR_0419812 R C mis40--------
    rs350874221,2
    C--7865655(+) AGTAA-/ACACATG 1 -- int10--------
    rs1425080951,2
    C--26826800(+) AAAGCC/TTACAT 1 -- int10--------
    rs79975241,2
    C,F--26826867(+) GTAAAT/CGACAA 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1471506841,2
    C--26826916(+) TTATAC/TAGTAT 1 -- int10--------
    rs1162190121,2
    C,F--26826923(+) GTATGC/TTAGGT 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1403065051,2
    --26826964(+) GTCACA/TAATTT 1 -- int10--------
    rs80022261,2
    C,F,A,H--26827054(+) ATGGAT/ACTTTT 1 -- int124Minor allele frequency- A:0.16NA NS EA WA 2516
    rs764282061,2
    F--26827135(+) CTAGGT/ATTTAC 1 -- int11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for CDK8 (26828276 - 26979375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268548CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603184    OMIM disorders: --

    13 diseases for CDK8:    About MalaCards
    noma    gastric adenocarcinoma    esophageal squamous cell carcinoma    mental retardation
    esophagitis    squamous cell carcinoma    sarcoma    adenocarcinoma
    colorectal cancer    thyroiditis    melanoma    lung cancer
    neuronitis


    CDK8 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CDK8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 20514474 (3), 20454513 (1), 20098423 (1), 16969500 (1) (see all 5)

    Genetic Association Database (GAD): CDK8
    Human Genome Epidemiology (HuGE) Navigator: CDK8 (2 documents)

    Export disorders for CDK8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK8 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with CDK8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. (PubMed id 7568034)1, 2, 3, 9 Tassan J.-P.... Nigg E.A. (1995)
    2. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. (PubMed id 15546612)1, 2, 9 Fryer C.J.... Jones K.A. (2004)
    3. The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. (PubMed id 21806996)1, 2 Schneider E.V....Maskos K. (2011)
    4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    6. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (2000)
    7. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (1999)
    8. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (1998)
    9. Role of CDK8 and beta-catenin in colorectal adenocarc inoma. (PubMed id 20514474)1, 9 Seo J.O....Lim S.C. (2010)
    10. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. (PubMed id 19790197)1, 9 Firestein R....Ogino S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1024 HGNC: 1779 AceView: CDK8 Ensembl:ENSG00000132964 euGenes: HUgn1024
    ECgene: CDK8 H-InvDB: CDK8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK8 gene:
    Search GeneIP for patents involving CDK8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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