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CDK7 Gene

protein-coding   GIFtS: 73
GCID: GC05P068530

Cyclin-Dependent Kinase 7

(Previous names: cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 71 2     EC 2.7.11.223 8
CAK12 3 5     Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase)1
STK12 3 5     HCAK2
Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating
Kinase)1 2
     Homolog Of Xenopus MO15 Cdk-Activating Kinase2
39 KDa Protein Kinase2 3     Kinase Subunit Of CAK2
Cell Division Protein Kinase 72 3     p39MO152
Serine/Threonine-Protein Kinase 12 3     Protein Kinase2
CAK2 3     Serine/Threonine Kinase Stk12
CDKN72 3     Serine/Threonine Protein Kinase 12
MO152 3     Serine/Threonine Protein Kinase MO152
CDK-Activating Kinase 12 3     EC 2.7.11.233
P39 Mo152 3     EC 2.7.118
TFIIH Basal Transcription Factor Complex Kinase Subunit2 3     EC 2.7.11.248

External Ids:    HGNC: 17781   Entrez Gene: 10222   Ensembl: ENSG000001340587   OMIM: 6019555   UniProtKB: P506133   

Export aliases for CDK7 gene to outside databases

Previous GC identifers: GC05P068682 GC05P070096 GC05P068501 GC05P068546 GC05P068566 GC05P065486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK7 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex
with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the
transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought
to serve as a direct link between the regulation of transcription and the cell cycle. (provided by RefSeq, Jul
2008)

GeneCards Summary for CDK7 Gene:
CDK7 (cyclin-dependent kinase 7) is a protein-coding gene. Diseases associated with CDK7 include cockayne syndrome, and xeroderma pigmentosum. GO annotations related to this gene include transcription coactivator activity and protein C-terminus binding. An important paralog of this gene is CDKL1.

UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613
Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA
transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the
progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent
phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M
transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the
catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A,
p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4
and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH
basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus
domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the
transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering
dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage,
triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may
lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required
for DNA-bound peptides-mediated transcription and cellular growth inhibition

Gene Wiki entry for CDK7 (Cyclin-dependent kinase 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK7 gene promoter:
         GR   AML1a   POU2F1   ATF-2   POU2F1a   GR-alpha   c-Jun   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK7 promoter sequence
   Search Chromatin IP Primers for CDK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q12.1

CDK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068530:  view genomic region     (about GC identifiers)

Start:
68,530,622 bp from pter      End:
68,573,257 bp from pter
Size:
42,636 bases      Orientation:
plus strand

1 alternative location:
Chr5+,NW_003315917.2 17,975-60,596     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 7  
Size: 346 amino acids; 39038 Da
Subunit: Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate
with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK
complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI
4 PDB 3D structures from and Proteopedia for CDK7:
1LG3 (3D)        1PA8 (3D)        1UA2 (3D)        2HIC (3D)    
Secondary accessions: Q9BS60 Q9UE19

Explore the universe of human proteins at neXtProt for CDK7: NX_P50613

Explore proteomics data for CDK7 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for
    activity. Phosphorylated at Ser-164 and Thr-170 by CDK21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK7 (P50613) (see all 5)
     LADFGLA  LREIKLL  LGTPTEE  ILHRDLK 


    See CDK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001790.1  
    ENSEMBL proteins: 
     ENSP00000425043   ENSP00000256443   ENSP00000425893   ENSP00000426372   ENSP00000425983  
     ENSP00000426561   ENSP00000422737   ENSP00000422027   ENSP00000421559   ENSP00000422121  
    Reactome Protein details: P50613

    CDK7 Human Recombinant Protein Products:

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    Novus Biologicals CDK7 Proteins
    Novus Biologicals CDK7 Lysates
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK7

    CDK7 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CDK7

    CDK7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CDK7
    Cloud-Clone Corp. CLIAs for CDK7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TFIIH: General transcription factor IIH complex subunits
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 7
    CDK7 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P50613

    ProtoNet protein and cluster: P50613

    UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK7_HUMAN, P50613
    Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA
    transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the
    progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent
    phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M
    transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the
    catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A,
    p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4
    and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH
    basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus
    domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the
    transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering
    dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage,
    triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may
    lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required
    for DNA-bound peptides-mediated transcription and cellular growth inhibition
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Enzyme regulation: Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547
    (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage
    reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminus domain (CTD), thus stopping cell
    cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells
    Induction: Repressed by DNA-bound peptides

         Genatlas biochemistry entry for CDK7:
    CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,forming
    aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH
    (GTF2H),putatively involved in cell cycle control,transcription DNA repair

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112 EC 2.7.11.242

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0004672protein kinase activity TAS7533895
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    CDK7 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDK7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased cell death HMECs cel 
     Increased cell death in breast 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdk7):
     adipose tissue  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  integument  mortality/aging  pigmentation 
     renal/urinary system  skeleton 

    CDK7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK7:
    hsa-mir-98-5p (MIRT027787), hsa-mir-423-3p (MIRT042517)

    Block miRNA regulation of human, mouse, rat CDK7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK7 (see all 12):
    hsa-miR-222* hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-198 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-33a* hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDK7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK7

    Clone
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: CDK7 (NM_001799)
    Sino Biological Human cDNA Clone for CDK7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK7

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK7_HUMAN, P50613: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the
    cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound
    peptides
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005675holo TFIIH complex IDA9852112
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    CDK7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK7 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    RNA Polymerase II Pre-transcription Events0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    Formation of the Early Elongation Complex0.77
    RNA Polymerase II Transcription Initiation0.67
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Dual incision reaction in GG-NER0.62
    Nucleotide excision repair0.69
    Formation of incision complex in GG-NER0.62
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cyclin D associated events in G10.31
    G1 Phase0.31
    4E2F mediated regulation of DNA replication
    G1/S Transition0.81
    G1 to S cell cycle control0.35
    Mitotic G1-G1/S phases0.81
    5DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    Formation of transcription-coupled NER (TC-NER) repair complex0.65
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    Dual incision reaction in TC-NER0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK7
        Cyclins and Cell Cycle Regulation
    Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway
    Sperm Motility
    RAR-Gamma-RXR-Alpha Degradation

    1 Cell Signaling Technology (CST) Pathway for CDK7
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CDK7
        Cell cycle Regulation of G1/S transition (part 2)
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    Selected BioSystems Pathways for CDK7 (see all 6)
        MicroRNAs in cardiomyocyte hypertrophy
    G1 to S cell cycle control
    Eukaryotic Transcription Initiation
    Integrated Breast Cancer Pathway
    B Cell Receptor Signaling Pathway


    Selected Reactome Pathways for CDK7 (see all 31)
        Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase I Promoter Escape
    NoRC negatively regulates rRNA expression
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    3 Kegg Pathways  (Kegg details for CDK7):
        Basal transcription factors
    Nucleotide excision repair
    Cell cycle


    CDK7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK7: 
              HIV Host Response in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK7 (P506131, 2, 3 ENSP000002564434) via UniProtKB, MINT, STRING, and/or I2D (see all 220)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010941, 3, ENSP000003455714EBI-1245958,EBI-448924 I2D: score=3 STRING: ENSP00000345571
    ENSG00000233149Q927593, ENSP000003954974I2D: score=1 STRING: ENSP00000395497
    ENSG00000236895Q927593, ENSP000003962514I2D: score=1 STRING: ENSP00000396251
    GTF2H4Q927593, ENSP000002598954I2D: score=1 STRING: ENSP00000259895
    ENSG00000221974Q927593I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS7533895
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--

    CDK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK7
    Selected ApexBio Compounds for CDK7 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Browse Tocris compounds for CDK7

    2 HMDB Compounds for CDK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for CDK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonothreonine-- --target--17139284 17016423
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    Selected Novoseek inferred chemical compound relationships for CDK7 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 77.8 17 19911397 (2), 17942543 (2), 17901130 (1), 15308730 (1) (see all 8)
    threonine 56.7 18 8208544 (3), 11113184 (2), 8182057 (2), 7799941 (1) (see all 11)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 50.5 3 17047081 (1)
    atp 28.5 9 15530371 (1), 8060530 (1), 17386261 (1), 10866826 (1) (see all 5)
    serine 28.4 4 8208544 (3), 9696809 (1)
    cyclic amp 10.1 8 9774149 (3), 8647207 (1)
    retinoic acid 4.5 2 10748061 (1), 10896783 (1)
    cgmp 1.98 3 8384796 (2), 11514553 (1)
    nitric oxide 0 1 8384796 (1)
    progesterone 0 1 2209545 (1)



    CDK7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK7 gene: 
    NM_001799.3  

    Unigene Cluster for CDK7:

    Cyclin-dependent kinase 7
    Hs.184298  [show with all ESTs]
    Unigene Representative Sequence: NM_001799
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506563 ENST00000512687(uc010ixd.1) ENST00000256443(uc021xzo.1 uc003jvs.4 uc003jvt.4)
    ENST00000515391 ENST00000512985 ENST00000515180 ENST00000506789 ENST00000510106
    ENST00000514676 ENST00000504147 ENST00000508726 ENST00000502604 ENST00000513629

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-222* hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-198 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-33a* hsa-miR-199a-5p
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    Additional mRNA sequence: 

    AK026509.1 AK308493.1 BC000834.2 BC005298.1 L20320.1 X77303.1 X77743.1 X79193.1 
    Y13120.1 

    13 DOTS entries:

    DT.445805  DT.100890371  DT.91732806  DT.95108778  DT.100835295  DT.100890386  DT.97846650  DT.91965922 
    DT.92027722  DT.120847977  DT.40117295  DT.91801854  DT.95331487 

    Selected AceView cDNA sequences (see all 207):

    BM922127 BM544823 BU634020 BP872612 BF512605 BI914644 BQ013338 X77303 
    BU069814 BQ431198 AA748836 AI277799 AI311067 CR611671 CA416765 BG820496 
    CA305960 BF793270 F02366 H94003 CR600515 BQ007571 BC005298 AI291351 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDK7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                                
    SP2:                          -                                                                     
    SP3:                          -                                                                     
    SP4:                                                        -                                       


    ECgene alternative splicing isoforms for CDK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK7 Expression
    About this image


    CDK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Secondary Oocyte Antral Follicle
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CDK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184298

    UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK7: 
              HIV Host Response in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK7 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk71 , 5 cyclin-dependent kinase 71, 5 87.67(n)1
    95.09(a)1
      13 (53.23 cM)5
    125721  NM_009874.31  NP_034004.21 
     1006970275 
    chicken
    (Gallus gallus)
    Aves CDK71 cyclin-dependent kinase 7 79.59(n)
    88.34(a)
      771294  XM_001234586.3  XP_001234587.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK76
    cyclin-dependent kinase 7
    88(a)
    1 ↔ 1
    2(12403766-12416875)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.17682 Xenopus MO15 mRNA for 40 kDa protein kinase, cdc2-related 80.14(n)    X53962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK237063.12   -- 78.88(n)    CK237063.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk71 , 3 regulation of CDK activity protein
    serine/threonine more3
    Cyclin-dependent kinase 71
    66(a)
    (best of 2)3
    61.11(n)1
    67.54(a)1
      4F43
    314411  NM_078489.21  NP_511044.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H01G02.23
    cdk-71
    serine/threonine kinase (2 domains)3
    cdk-71
    40(a)3
    59.27(n)1
    60.93(a)1
      IV(11798872-11801260)3
    1717841  NM_058551.61  NP_490952.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN28(YDL108W)4
    KIN281
    Serine/threonine protein kinase, subunit of the transcription more4
    KIN281
    54.51(n)1
    49.31(a)1
      4(267698-268699)4
    8514501, 4  NP_010175.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAK41 CAK4 58.04(n)
    56.63(a)
      842993  NM_105345.4  NP_176847.1 
    rice
    (Oryza sativa)
    Liliopsida Os.26892 O.sativa mRNA for cdc2+/CDC28-related protein kinase 71.44(n)    X58194.1 


    ENSEMBL Gene Tree for CDK7 (if available)
    TreeFam Gene Tree for CDK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK7 gene
    CDKL12  CDK202  CDKL22  CDKL52  CDKL32  CDKL42  
    Selected SIMAP similar genes for CDK7 using alignment to 10 protein entries:     CDK7_HUMAN (see all proteins) (see all similar genes):
    CDK1    CDK18    CDC2    CSNK2A2    CDK3    DKFZp686L20222
    DYRK4    DYRK1A    CDK16    CDKL2    CDK11B    CDK5
    CDK11A    CDK2    CDK4    CDC2L1    CDKL5    MAPK7

    CDK7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK7
    PGOHUM00000240398


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK7 (see all 878)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs577274131,2
    C--65485718(+) ACAAA-/CAAA  
            
    GGCAG
    1 -- us2k12Minor allele frequency- CAAA:0.25NA 4
    rs1476003341,2
    C--68528637(+) ATGGGG/TTTTCA 1 -- us2k10--------
    rs1407776971,2
    --68528651(+) TGTTGG/TCCAGG 1 -- us2k10--------
    rs1884390241,2
    --68528795(+) ATACCC/TGTCAG 1 -- us2k10--------
    rs1501032061,2
    --68528813(+) TATGAC/TAACAG 1 -- us2k10--------
    rs1385989751,2
    --68528823(+) GCATCA/GCTAGG 1 -- us2k10--------
    rs29723571,2
    C,F,O,A,H--68528843(-) CTCTCT/CTGAGG 1 -- us2k127Minor allele frequency- C:0.29NS EA NA CSA WA 3121
    rs1818598991,2
    --68528996(+) TGGAAA/CAATCC 1 -- us2k10--------
    rs1863470151,2
    --68529090(+) TAGGGC/TCACTA 1 -- us2k10--------
    rs1488698461,2
    C--68529149(+) ATTGGC/TCTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK7 (68530622 - 68573257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821643CNV Loss15273396

    Human Gene Mutation Database (HGMD): CDK7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK7
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601955    OMIM disorders: --

    Selected diseases for CDK7 (see all 31):    
    About MalaCards
    cockayne syndrome    xeroderma pigmentosum    cytomegalovirus infection    hemangioma
    hepatoblastoma    lung cancer susceptibility    diabetic nephropathy    endometrial carcinoma
    hiv-1    herpes simplex    ovarian cancer    retinoblastoma
    alzheimer's disease    esophageal squamous cell carcinoma    multiple sclerosis    tonsillitis
    esophagitis    breast cancer    neuroblastoma    hepatitis b

    4 diseases from the University of Copenhagen DISEASES database for CDK7:
    Xeroderma pigmentosum     Photosensitive trichothiodystrophy     Cockayne syndrome     Retinoblastoma

    CDK7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CDK7 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 50.9 1 11331764 (1)
    cancer 13.2 6 19638587 (1), 17386261 (1), 8208544 (1), 15876871 (1)
    glioma 11.6 2 11856176 (2)
    shock 0 2 12972606 (2)
    breast cancer 0 6 19941161 (4), 8208544 (1), 14634505 (1)
    colon carcinoma 0 1 12663041 (1)
    ovarian cancer 0 1 19738611 (1)
    glioblastoma 0 1 8806696 (1)
    alzheimers disease 0 2 11124424 (2)
    carcinoma 0 2 8208544 (2)

    Genetic Association Database (GAD): CDK7
    Human Genome Epidemiology (HuGE) Navigator: CDK7 (15 documents)

    Export disorders for CDK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK7 gene, integrated from 10 sources (see all 320):
    (articles sorted by number of sources associating them with CDK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)1, 2, 3, 9 Fisher R.P. and Morgan D.O. (Cell 1994)
    2. Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. (PubMed id 7936635)1, 2, 9 Darbon J.-M.... Blanchard J.-M. (Oncogene 1994)
    3. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PubMed id 8208544)1, 2, 9 Levedakou E.N.... Liu E.T. (Oncogene 1994)
    4. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. (PubMed id 11113184)1, 2, 9 Garrett S.... Fisher R.P. (Mol. Cell. Biol. 2001)
    5. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. (PubMed id 17386261)1, 2, 9 Larochelle S.... Fisher R.P. (Mol. Cell 2007)
    6. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). (PubMed id 7929589)1, 2, 9 Tassan J.-P.... Nigg E.A. (J. Cell Biol. 1994)
    7. CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? (PubMed id 15876871)1, 2, 9 Lolli G. and Johnson L.N. (Cell Cycle 2005)
    8. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. (PubMed id 9372954)1, 2, 9 Ko L.J.... Pan Z.-Q. (Mol. Cell. Biol. 1997)
    9. TFIIH-associated Cdk7 kinase functions in phosphorylation of C- terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. (PubMed id 19667075)1, 2, 9 Glover-Cutter K.... Bentley D.L. (Mol. Cell. Biol. 2009)
    10. Phosphorylation of steroidogenic factor 1 is mediated by cyclin- dependent kinase 7. (PubMed id 17901130)1, 2, 9 Lewis A.E.... Bakke M. (Mol. Endocrinol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1022 HGNC: 1778 AceView: CDK7 Ensembl:ENSG00000134058 euGenes: HUgn1022
    ECgene: CDK7 Kegg: 1022 H-InvDB: CDK7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK7 gene:
    Search GeneIP for patents involving CDK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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