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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK7 Gene

protein-coding   GIFtS: 72
GCID: GC05P068530

Cyclin-Dependent Kinase 7

(Previous names: cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 71 2     EC 2.7.11.223 8
CAK12 3 5     Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase)1
STK12 3 5     HCAK2
Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating
Kinase)1 2
     Homolog Of Xenopus MO15 Cdk-Activating Kinase2
39 KDa Protein Kinase2 3     Kinase Subunit Of CAK2
Cell Division Protein Kinase 72 3     p39MO152
Serine/Threonine-Protein Kinase 12 3     Protein Kinase2
CAK2 3     Serine/Threonine Kinase Stk12
CDKN72 3     Serine/Threonine Protein Kinase 12
MO152 3     Serine/Threonine Protein Kinase MO152
CDK-Activating Kinase 12 3     EC 2.7.11.233
P39 Mo152 3     EC 2.7.118
TFIIH Basal Transcription Factor Complex Kinase Subunit2 3     EC 2.7.11.248

External Ids:    HGNC: 17781   Entrez Gene: 10222   Ensembl: ENSG000001340587   OMIM: 6019555   UniProtKB: P506133   

Export aliases for CDK7 gene to outside databases

Previous GC identifers: GC05P068682 GC05P070096 GC05P068501 GC05P068546 GC05P068566 GC05P065486


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK7 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex
with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the
transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought
to serve as a direct link between the regulation of transcription and the cell cycle. (provided by RefSeq, Jul
2008)

GeneCards Summary for CDK7 Gene: 
CDK7 (cyclin-dependent kinase 7) is a protein-coding gene. Diseases associated with CDK7 include xeroderma pigmentosum, and cytomegalovirus infection, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Global Genomic NER (GG-NER). GO annotations related to this gene include transcription coactivator activity and protein C-terminus binding. An important paralog of this gene is CDK20.

UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613
Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA
transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the
progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent
phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M
transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the
catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A,
p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4
and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH
basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus
domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the
transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering
dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage,
triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may
lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required
for DNA-bound peptides-mediated transcription and cellular growth inhibition

Gene Wiki entry for CDK7 (Cyclin-dependent kinase 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK7 gene promoter:
         GR   AML1a   POU2F1   ATF-2   POU2F1a   GR-alpha   c-Jun   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q12.1

CDK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068530:  view genomic region     (about GC identifiers)

Start:
68,530,622 bp from pter      End:
68,573,257 bp from pter
Size:
42,636 bases      Orientation:
plus strand

1 alternative location:
Chr5+,NW_003315917.2 17,975-60,596     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 7  
Size: 346 amino acids; 39038 Da
Subunit: Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate
with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK
complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the
cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound
peptides
4 PDB 3D structures from and Proteopedia for CDK7:
1LG3 (3D)        1PA8 (3D)        1UA2 (3D)        2HIC (3D)    
Secondary accessions: Q9BS60 Q9UE19

Explore the universe of human proteins at neXtProt for CDK7: NX_P50613

Explore proteomics data for CDK7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for
    activity. Phosphorylated at Ser-164 and Thr-170 by CDK2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50613

  • 4/5 DME Specific Peptides for CDK7 (P50613) (see all 5)
     LADFGLA  LREIKLL  LGTPTEE  ILHRDLK 

    CDK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK7 Protein Expression
    REFSEQ proteins: NP_001790.1  
    ENSEMBL proteins: 
     ENSP00000425043   ENSP00000256443   ENSP00000425893   ENSP00000426372   ENSP00000425983  
     ENSP00000426561   ENSP00000422737   ENSP00000422027   ENSP00000421559   ENSP00000422121  
    Reactome Protein details: P50613
    Human Recombinant Protein Products for CDK7: 
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    Novus Biologicals CDK7 Proteins
    Novus Biologicals CDK7 Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for CDK7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005675holo TFIIH complex IDA9852112
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    CDK7 for ontologies           About GeneDecksing



    CDK7 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for CDK7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TFIIH: General transcription factor IIH complex subunits
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 7 
    CDK7 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P50613

    ProtoNet protein and cluster: P50613

    UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK7_HUMAN, P50613
    Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA
    transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the
    progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent
    phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M
    transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the
    catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A,
    p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4
    and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH
    basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus
    domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the
    transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering
    dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage,
    triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may
    lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required
    for DNA-bound peptides-mediated transcription and cellular growth inhibition
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Enzyme regulation: Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547
    (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage
    reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminus domain (CTD), thus stopping cell
    cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells
    Induction: Repressed by DNA-bound peptides

         Genatlas biochemistry entry for CDK7:
    CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,forming
    aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH
    (GTF2H),putatively involved in cell cycle control,transcription DNA repair

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112 EC 2.7.11.242

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0004672protein kinase activity TAS7533895
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    CDK7 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDK7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased cell death HMECs cel 
     Increased cell death in breast 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdk7):
     adipose tissue  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  integument  mortality/aging  pigmentation 
     renal/urinary system  skeleton 

    CDK7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK7
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK7 (see all 12):
    hsa-miR-222* hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-198 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-33a* hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDK7 3' UTR sequence
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of CDK7 Gene knock-down
    OriGene RNAi products in human, mouse, rat for CDK7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK7

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CDK7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK7 (see all 9)
    OriGene ORF clones in mouse, rat for CDK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK7 (NM_001799)
    Sino Biological Human cDNA Clone for CDK7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK7
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                         Customized lentivirus expression plasmids for stable overexpression of CDK7 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK7 About   (see all 30)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    RNA Polymerase II Pre-transcription Events0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.70
    mRNA Capping0.93
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    HIV Transcription Elongation0.78
    RNA Polymerase II HIV Promoter Escape0.67
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.70
    Dual incision reaction in GG-NER0.61
    Nucleotide excision repair0.70
    Formation of incision complex in GG-NER0.61
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cyclin D associated events in G10.32
    G1 Phase0.32
    4Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    5RNA Polymerase I Chain Elongation
    RNA Polymerase I Promoter Clearance0.92
    RNA Polymerase I Chain Elongation0.90
    RNA Polymerase I Transcription0.92
    RNA Polymerase I Transcription Initiation0.90
    RNA Polymerase I Promoter Escape0.91
    RNA Polymerase I Transcription Termination0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CDK7
        Cell cycle Regulation of G1/S transition (part 2)
    Meiosis
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK7
        Cyclins and Cell Cycle Regulation
    Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway
    Sperm Motility
    RAR-Gamma-RXR-Alpha Degradation

    1 Cell Signaling Technology (CST) Pathway for CDK7
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CDK7
        Cell cycle Regulation of G1/S transition (part 2)
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/6 BioSystems Pathways for CDK7 (see all 6)
        MicroRNAs in cardiomyocyte hypertrophy
    G1 to S cell cycle control
    Eukaryotic Transcription Initiation
    Integrated Breast Cancer Pathway
    B Cell Receptor Signaling Pathway


    5/54        Reactome Pathways for CDK7 (see all 54)
        Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase I Promoter Escape
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase I Transcription
    S Phase


    3         Kegg Pathways  (Kegg details for CDK7):
        Basal transcription factors
    Nucleotide excision repair
    Cell cycle


    CDK7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/176 Interacting proteins for CDK7 (P506131, 2, 3 ENSP000002564434) via UniProtKB, MINT, STRING, and/or I2D (see all 176)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010941, 3, ENSP000003455714EBI-1245958,EBI-448924 I2D: score=3 STRING: ENSP00000345571
    ENSG00000233149Q927593, ENSP000003954974I2D: score=1 STRING: ENSP00000395497
    ENSG00000236895Q927593, ENSP000003962514I2D: score=1 STRING: ENSP00000396251
    GTF2H4Q927593, ENSP000002598954I2D: score=1 STRING: ENSP00000259895
    ENSG00000221974Q927593I2D: score=1 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS7533895
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--

    CDK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK7 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK7:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CDK7

    Browse Tocris compounds for CDK7

    2 HMDB Compounds for CDK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for CDK7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonothreonine-- --target--17139284 17016423
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    10/12 Novoseek inferred chemical compound relationships for CDK7 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 77.8 17 19911397 (2), 17942543 (2), 17901130 (1), 15308730 (1) (see all 8)
    threonine 56.7 18 8208544 (3), 11113184 (2), 8182057 (2), 7799941 (1) (see all 11)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 50.5 3 17047081 (1)
    atp 28.5 9 15530371 (1), 8060530 (1), 17386261 (1), 10866826 (1) (see all 5)
    serine 28.4 4 8208544 (3), 9696809 (1)
    cyclic amp 10.1 8 9774149 (3), 8647207 (1)
    retinoic acid 4.5 2 10748061 (1), 10896783 (1)
    cgmp 1.98 3 8384796 (2), 11514553 (1)
    nitric oxide 0 1 8384796 (1)
    progesterone 0 1 2209545 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK7 gene: 
    NM_001799.3  

    Unigene Cluster for CDK7:

    Cyclin-dependent kinase 7
    Hs.184298  [show with all ESTs]
    Unigene Representative Sequence: NM_001799
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506563 ENST00000512687(uc010ixd.1) ENST00000256443(uc021xzo.1 uc003jvs.4 uc003jvt.4)
    ENST00000515391 ENST00000512985 ENST00000515180 ENST00000506789 ENST00000510106
    ENST00000514676 ENST00000504147 ENST00000508726 ENST00000502604 ENST00000513629

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK026509.1 AK308493.1 BC000834.2 BC005298.1 L20320.1 X77303.1 X77743.1 X79193.1 
    Y13120.1 

    13 DOTS entries:

    DT.445805  DT.100890371  DT.91732806  DT.95108778  DT.100835295  DT.100890386  DT.97846650  DT.91965922 
    DT.92027722  DT.120847977  DT.40117295  DT.91801854  DT.95331487 

    24/207 AceView cDNA sequences (see all 207):

    BU631128 AI311067 F02366 BU069814 CR620322 BX490410 BM544823 BQ431198 
    AI017756 BM922127 BQ425126 BF793270 CA423628 CA416765 H94003 BQ013338 
    CR611671 BI831473 BQ776285 CN479963 BC000834 BG820496 BQ432504 CA435215 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDK7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                                
    SP2:                          -                                                                     
    SP3:                          -                                                                     
    SP4:                                                        -                                       


    ECgene alternative splicing isoforms for CDK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK7 expression in normal human tissues (normalized intensities)      CDK7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK7 Expression
    About this image


    CDK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See CDK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK7

    SOURCE GeneReport for Unigene cluster: Hs.184298

    UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK7: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK7 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk71 , 5 cyclin-dependent kinase 71, 5 87.67(n)1
    95.09(a)1
      13 (53.23 cM)5
    125721  NM_009874.31  NP_034004.21 
     1006970275 
    chicken
    (Gallus gallus)
    Aves CDK71 cyclin-dependent kinase 7 79.59(n)
    88.34(a)
      771294  XM_001234586.2  XP_001234587.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK76
    Uncharacterized protein
    88(a)
    1 ↔ 1
    2(12403766-12416875)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.17682 Xenopus MO15 mRNA for 40 kDa protein kinase, cdc2-related 80.14(n)    X53962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK237063.12   -- 78.88(n)    CK237063.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk71 , 3 regulation of CDK activity protein
    serine/threonine more3
    Cyclin-dependent kinase 71
    66(a)
    (best of 2)3
    61.11(n)1
    67.54(a)1
      4F43
    314411  NM_078489.21  NP_511044.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H01G02.23
    cdk-71
    serine/threonine kinase (2 domains)3
    Protein CDK-71
    40(a)3
    59.27(n)1
    60.93(a)1
      IV(11798872-11801260)3
    1717841  NM_058551.51  NP_490952.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN28(YDL108W)4
    KIN281
    Serine/threonine protein kinase, subunit of the transcription more4
    Kin28p1
    54.4(n)1
    49.31(a)1
      4(267698-268699)4
    8514501, 4  NP_010175.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAK41 cyclin-dependent kinase D-2 58.04(n)
    56.63(a)
      842993  NM_105345.4  NP_176847.1 
    rice
    (Oryza sativa)
    Liliopsida Os.26892 O.sativa mRNA for cdc2+/CDC28-related protein kinase 71.44(n)    X58194.1 


    ENSEMBL Gene Tree for CDK7 (if available)
    TreeFam Gene Tree for CDK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK7 gene
    CDK202  CDK11A2  CDK102  CDK11B2  
    18/99 SIMAP similar genes for CDK7 using alignment to 10 protein entries:     CDK7_HUMAN (see all proteins) (see all similar genes):
    CDK1    CDK18    CDC2    CSNK2A2    CDK3    DKFZp686L20222
    DYRK4    DYRK1A    CDK16    CDKL2    CDK11B    CDK5
    CDK11A    CDK2    CDK4    CDC2L1    CDKL5    MAPK7

    CDK7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK7
    PGOHUM00000240398


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/878 SNPs in CDK7 are shown (see all 878)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0231184
    ----see VAR_0231182 G A mis40--------
    rs577274131,2
    C--65485718(+) ACAAA-/CAAA  
            
    GGCAG
    1 -- us2k12Minor allele frequency- CAAA:0.25NA 4
    rs1476003341,2
    C--68528637(+) ATGGGG/TTTTCA 1 -- us2k10--------
    rs1407776971,2
    --68528651(+) TGTTGG/TCCAGG 1 -- us2k10--------
    rs1884390241,2
    --68528795(+) ATACCC/TGTCAG 1 -- us2k10--------
    rs1501032061,2
    --68528813(+) TATGAC/TAACAG 1 -- us2k10--------
    rs1385989751,2
    --68528823(+) GCATCA/GCTAGG 1 -- us2k10--------
    rs29723571,2
    C,F,O,A,H--68528843(-) CTCTCT/CTGAGG 1 -- us2k127Minor allele frequency- C:0.29NS EA NA CSA WA 3121
    rs1818598991,2
    --68528996(+) TGGAAA/CAATCC 1 -- us2k10--------
    rs1863470151,2
    --68529090(+) TAGGGC/TCACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK7 (68530622 - 68573257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821643CNV Loss15273396

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601955    OMIM disorders: --

    20/22 diseases for CDK7 (see all 22):    About MalaCards
    xeroderma pigmentosum    cytomegalovirus infection    hemangioma    hepatoblastoma
    esophageal adenocarcinoma    glioblastoma    endometrial carcinoma    herpes simplex
    retinoblastoma    alzheimer's disease    multiple sclerosis    ovarian cancer
    hepatitis b    esophagitis    breast cancer    lung cancer
    neuroblastoma    thyroiditis    hepatitis    adenocarcinoma

    4 diseases from the University of Copenhagen DISEASES database for CDK7:
    Xeroderma pigmentosum     Photosensitive trichothiodystrophy     Cockayne syndrome     Retinoblastoma

    CDK7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for CDK7 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 50.9 1 11331764 (1)
    cancer 13.2 6 19638587 (1), 17386261 (1), 8208544 (1), 15876871 (1)
    glioma 11.6 2 11856176 (2)
    shock 0 2 12972606 (2)
    breast cancer 0 6 19941161 (4), 8208544 (1), 14634505 (1)
    colon carcinoma 0 1 12663041 (1)
    ovarian cancer 0 1 19738611 (1)
    glioblastoma 0 1 8806696 (1)
    alzheimers disease 0 2 11124424 (2)
    carcinoma 0 2 8208544 (2)

    Genetic Association Database (GAD): CDK7
    Human Genome Epidemiology (HuGE) Navigator: CDK7 (15 documents)

    Export disorders for CDK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK7 gene, integrated from 9 sources (see all 318):
    (articles sorted by number of sources associating them with CDK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)1, 2, 3, 9 Fisher R.P. and Morgan D.O. (1994)
    2. Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. (PubMed id 7936635)1, 2, 9 Darbon J.-M.... Blanchard J.-M. (1994)
    3. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PubMed id 8208544)1, 2, 9 Levedakou E.N.... Liu E.T. (1994)
    4. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. (PubMed id 11113184)1, 2, 9 Garrett S....Fisher R.P. (2001)
    5. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. (PubMed id 17386261)1, 2, 9 Larochelle S....Fisher R.P. (2007)
    6. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). (PubMed id 7929589)1, 2, 9 Tassan J.-P.... Nigg E.A. (1994)
    7. CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? (PubMed id 15876871)1, 2, 9 Lolli G. and Johnson L.N. (2005)
    8. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. (PubMed id 9372954)1, 2, 9 Ko L.J....Pan Z.Q. (1997)
    9. TFIIH-associated Cdk7 kinase functions in phosphoryla tion of C-terminal domain Ser7 residues, promoter-proximal pausing, and termina tion by RNA polymerase II. (PubMed id 19667075)1, 2, 9 Glover-Cutter K....Bentley D.L. (2009)
    10. Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7. (PubMed id 17901130)1, 2, 9 Lewis A.E....Bakke M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1022 HGNC: 1778 AceView: CDK7 Ensembl:ENSG00000134058 euGenes: HUgn1022
    ECgene: CDK7 Kegg: 1022 H-InvDB: CDK7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK7 gene:
    Search GeneIP for patents involving CDK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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