CDK7 Gene
protein-coding GIFtS: 71
GC05P068566
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cyclin-dependent kinase 7
(Previous names: cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase), cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for CDK7
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CAK 3 | | CAK1 1, 2, 3, 5 | | CDKN7 1, 2 | | EC 2.7.11.22,EC 2.7.11.23 3 | | MO15 1, 2, 3 | | STK1 1, 2, 3, 5 | | p39MO15 2 |
| | | Descriptions |
|---|
| 39 kDa protein kinase 2, 3 | | CDK-activating kinase 2, 3 | | P39 Mo15 3 | | TFIIH basal transcription factor complex kinase subunit 3 | | cell division protein kinase 7 2 | | cyclin-dependent kinase 7 2 | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis,
cdk-activating kinase) 1, 2 | cyclin-dependent kinase 7 (homolog of Xenopus MO15
cdk-activating kinase) 1 | | homolog of Xenopus MO15 Cdk-activating kinase 2 | | kinase subunit of CAK 2 | | serine/threonine kinase stk1 2 | | serine/threonine protein kinase 1 2 | | serine/threonine protein kinase MO15 2 |
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Search outside databases for aliases for CDK7 genePrevious GC identifers: GC05P068682 GC05P070096 GC05P068501 GC05P068546 |
Summaries
for CDK7(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CDK7:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family.
CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and
Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle
progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a
Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that
is involved in transcription initiation and DNA repair. This protein is thought to serve as a
direct link between the regulation of transcription and the cell cycle. [provided by RefSeq]
UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Function: Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the
progression through the cell cycle. Each different complex controls a specific transition between
two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating
kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases
CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal
transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive
C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and
elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA
polymerase II. Its expression and activity are constant throughout the cell cycleGene Wiki entry for CDK7 (Cyclin-dependent_kinase_7) |
Genomic Location
for CDK7
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the CDK7 gene 
Entrez Gene cytogenetic band: 5q12.1 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q12.1CDK7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P068566:
(about GC identifiers)
Start:
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68,566,471 bp from pter |
End:
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68,609,006 bp from pter |
Size:
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42,536 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr5+,c5_H2 68,990,831-69,033,352 |
RefSeq DNA sequence:- NC_000005.8 NT_006713.14 NT_113801.1
| Proteins
for CDK7
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613 (See
protein sequence)Recommended Name: Cell division protein kinase 7 Size: 346 amino acids; 39038 Da
Subunit: Associates primarily with cyclin H and MAT1 to form the CAK complex. CAK can further
associate with the core-TFIIH to form the TFIIH basal transcription factor. Interacts with PUF60
Subcellular location: Nucleus
PDB structures from  and Proteopedia  :1LG3 (3D)
1PA8 (3D)
1UA2 (3D)
2HIC (3D)
Secondary accessions: Q9BS60 Q9UE19Post-translational modifications:
Phosphorylation of Ser-164 during mitosis inactivates the enzyme1
Phosphorylation of Thr-170 is required for activity1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001790.1
ENSEMBL proteins: ENSP00000256443
Human Recombinant Proteins  OriGene Purified Recombinant Human Protein: CDK7
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CDK7:
Assays for CDK7: | Protein
Domains/
Families
for CDK7(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P50613
ProtoNet protein and cluster: P50613 UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain | Gene Function
for CDK7
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Inhib.
RNA: |  | Invitrogen RNAi Products for gene knock-down (CDK7) | |  | Millipore RNAi Products for the Analysis of CDK7 Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (CDK7) |
OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001799
 Applied Biosystems Silencer® siRNAs for CDK7
 Sigma-Aldrich siRNA and siRNA Panels for CDK7
Sigma-Aldrich shRNA Panels and shRNA for CDK7
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001799
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001799
untagged cDNA clones in CMV expression vector (see all 2): NM_001799
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_001799
UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Function: Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the
progression through the cell cycle. Each different complex controls a specific transition between
two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating
kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases
CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal
transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive
C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and
elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA
polymerase II. Its expression and activity are constant throughout the cell cycleCatalytic activity: ATP + a protein = ADP + a phosphoproteinCatalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase]
phosphateEnzyme regulation: Inactivated by phosphorylationEnzyme Number (IUBMB): EC 2.7.11.22,EC Genatlas biochemistry entry for CDK7:CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer
line,forming aternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit
complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription DNA repair1 MGI phenotypic allele  for Cdk7 (no phenotypes)
5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8
): About this table | Pathways & Interactions
for CDK7
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for CDK7 (Your Favorite Gene powered by Ingenuity) (see all 8
)
Gene Network CentralTM Interacting Genes and Proteins Network for CDK7
5/128 Interacting proteins for CDK7 (ENSP000002564433) via UniProtKB, MINT, and/or STRING (see all 128
)About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13
): About this table
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Drugs & Compounds
for CDK7(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Enzo Life Sciences drugs & compounds for CDK7 |
| Sigma-Aldrich Small Molecules for CDK7:
Inhibitor |
 Compounds for CDK7 available from Tocris Bioscience
6  Novoseek chemical compound relationships for CDK7 gene
About this table
|
Transcripts
for CDK7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| Inhib.
RNA: | | Invitrogen RNAi Products for gene knock-down (CDK7) | | | Millipore RNAi Products for the Analysis of CDK7 Gene knock-down | | | Abnova Chimera RNAi Products for Gene knock-down (CDK7) |
OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001799
Sigma-Aldrich siRNA and siRNA Panels for CDK7
Sigma-Aldrich shRNA Panels and shRNA for CDK7
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_001799 REFSEQ mRNAs for CDK7 gene: NM_001799.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001799
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001799
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001799
untagged cDNA clones in CMV expression vector (see all 2): NM_001799
Additional cDNA sequence: AK026509.1 AK308493.1 BC000834.2 BC005298.1 CR600515.1 CR611671.1 CR620322.1 L20320.1 X77303.1 X77743.1 X79193.1 Y13120.1 13 DOTS entries: DT.445805 DT.100890371 DT.91732806 DT.100890386 DT.95108778 DT.100835295 DT.97846650 DT.91965922 DT.92027722 DT.120847977 DT.40117295 DT.91801854 DT.95331487 24/207 AceView cDNA sequences (see all 207
):CR611671 AI017756 BU631128 BU069814 BQ776285 CN479963 BM544823 BQ013338 BC000834 CA310644 BP872612 BI831473 CA435215 F02366 H94003 BU634020 BC005298 BQ432504 BF793270 BM922127 CA305960 BG820496 CA446290 BQ007571
 highest scoring ESTs for CDK7:L20320 X77743 AA031961 AA041553 AA062916 AA181981 AA258118 AA496026 AA634429 AA648307 Unigene Cluster for CDK7: Cyclin-dependent kinase 7 Hs.184298 [show with all ESTs]Unigene Representative Sequence: NM_001799
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CDK7
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CDK7
1 Ensembl transcript including schematic representation: ENST00000256443
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Expression
for CDK7
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CDK7 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CDK7
1 / 2 / 3 4 probe-sets matching CDK7 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.184298
Expression variation in blood from EXPOLDB for CDK7 UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Tissue specificity: Ubiquitous |
Orthologs
for CDK7
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDK7 gene from 5/20 species (see all 20
)
About this table Species with no ortholog for CDK7
ENSEMBL Gene Tree for CDK7 | Paralogs
for CDK7(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CDK7 gene
- CDK62 CCRK2 CDK42
Pseudogenes
- 1 related pseudogene
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SNPs/Variants
for CDK7(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CDK7 (up to first 250kb)
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Disorders & Mutations
for CDK7
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601955
10/11 Novoseek disease relationships for CDK7 gene (see all 11
)
About this table
Human Gene Mutation Database: CDK7
Genetic Association Database: CDK7
Human Genome Epidemiology Navigator: CDK7 (3 documents)
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Medical News
for CDK7(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CDK7 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/246 PubMed articles for CDK7 gene (see all 246
):- A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)1, 2, 3, 4 Fisher R.P. and Morgan D.O. (1994)
- Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. (PubMed id 7936635)1, 3, 4 Darbon J.-M.... Blanchard J.-M. (1994)
- Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PubMed id 8208544)1, 3, 4 Levedakou E.N.... Liu E.T. (1994)
- Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). (PubMed id 7929589)1, 3, 4 Tassan J.-P.... Nigg E.A. (1994)
- The crystal structure of human CDK7 and its protein recognition properties. (PubMed id 15530371)1, 3, 4 Lolli G....Johnson L.N. (2004)
- Identification of single nucleotide polymorphisms in human DNA repair genes. (PubMed id 11062157)1, 3, 6 Ford B.N....Glickman B.W. (2000)
- Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)3, 4 Wissing J.... Daub H. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. (PubMed id 10024882)3, 4 Tirode F.... Egly J.-M. (1999)
- The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7. (PubMed id 9832506)3, 4 Akoulitchev S. and Reinberg D. (1998)
|
Search for CDK7
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDK7
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CDK7
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK7(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for CDK7(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for CDK7:
 | |
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 | Antibodies & Assays for CDK7 |
| | | | | Tocris compounds for CDK7 |
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Incremental update: 13 Oct 2009
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