CDK7 Gene
protein-coding GIFtS: 70
GCID: GC05P068530
|
|
cyclin-dependent kinase 7(Previous names: cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating...)
| |
Aliases
for CDK7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin-Dependent Kinase 71 2 | | EC 2.7.11.223 8 | | CAK11 2 3 5 | | Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase)1 | | STK11 2 3 5 | | HCAK2 | | CAK1 2 3 | | Homolog Of Xenopus MO15 Cdk-Activating Kinase2 | | CDKN71 2 3 | | Kinase Subunit Of CAK2 | | MO151 2 3 | | P39MO151 | | Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating Kinase)1 2 | | Protein Kinase2 | | 39 KDa Protein Kinase2 3 | | Serine/Threonine Kinase Stk12 | | Cell Division Protein Kinase 72 3 | | Serine/Threonine Protein Kinase 12 | | Serine/Threonine-Protein Kinase 12 3 | | Serine/Threonine Protein Kinase MO152 | | CDK-Activating Kinase 12 3 | | EC 2.7.11.233 | | P39 Mo152 3 | | EC 2.7.118 | | TFIIH Basal Transcription Factor Complex Kinase Subunit2 3 | | EC 2.7.11.248 |
Export aliases for CDK7 gene to outside databasesPrevious GC identifers: GC05P068682 GC05P070096 GC05P068501 GC05P068546 GC05P068566 GC05P065486 |
Summaries
for CDK7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDK7:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family membersare highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and areknown to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H andMAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factorTFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct linkbetween the regulation of transcription and the cell cycle. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription.Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cellcycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Requiredfor both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclinsduring G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK)complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAKactivates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cellcycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serinephosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from thepromoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcriptioninitiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle.Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; thisfeedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or toapoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition
Gene Wiki entry for CDK7 (Cyclin-dependent kinase 7)
|
Genomic Views
for CDK7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDK7 gene promoter:
GR AML1a POU2F1 ATF-2 POU2F1a GR-alpha c-Jun Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDK7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q12.1 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q12.1CDK7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P068530: view genomic region
(about GC identifiers)
Start:
|
68,530,622 bp from pter |
End:
|
68,573,257 bp from pter |
Size:
|
42,636 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr5+,PATCHES 68,922,968-68,965,589 |
|
Proteins
for CDK7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613 (See
protein sequence)Recommended Name: Cyclin-dependent kinase 7 Size: 346 amino acids; 39038 Da
Subunit: Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with thecore-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex bindsto p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasmand nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides
4 PDB 3D structures from  and Proteopedia  for CDK7:1LG3 (3D)
1PA8 (3D)
1UA2 (3D)
2HIC (3D)
Secondary accessions: Q9BS60 Q9UE19Explore the universe of human proteins at neXtProt for CDK7: NX_P50613
Post-translational modifications:
Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity.Phosphorylated at Ser-164 and Thr-170 by CDK21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P50613
4/5 DME Specific Peptides for CDK7 (P50613) (see all 5)
CDK7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001790.1
ENSEMBL proteins: ENSP00000425043 ENSP00000256443 ENSP00000425893 ENSP00000426372 ENSP00000425983 ENSP00000426561 ENSP00000422737 ENSP00000422027 ENSP00000421559 ENSP00000422121 Reactome Protein details: P50613
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
CDK7 for ontologies About GeneDecksing
CDK7 Antibody Products:
Assay Products for CDK7: |
Protein
Domains /
Families
for CDK7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDK7 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P50613ProtoNet protein and cluster: P50613 UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CDK7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription.Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cellcycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Requiredfor both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclinsduring G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK)complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAKactivates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cellcycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serinephosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from thepromoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcriptioninitiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle.Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; thisfeedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or toapoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibitionCatalytic activity: ATP + a protein = ADP + a phosphoproteinCatalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphateEnzyme regulation: Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547 (Ro-4584820) andSNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage reduces kinase activitytoward CDK2 and RNA polymerase II repetitive C-terminus domain (CTD), thus stopping cell cycle progression. Theinactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cellsInduction: Repressed by DNA-bound peptides Genatlas biochemistry entry for CDK7:CDK-activating kinase 1,homolog of Xenopus p40-M015,gene or pseudogene,expressed in a breast cancer line,formingaternary complex with CCNH and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putativelyinvolved in cell cycle control,transcription DNA repair
Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112 EC 2.7.11.242
Inhib. RNA
Products: |  | EMD Millipore RNAi Products for the Analysis of CDK7 Gene knock-down | |  | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK7 (see all 4)
OriGene shRNA RFP: CDK7
OriGene siRNA: CDK7
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK7 |
Clone
Products: | | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDK7 (NM_001799) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK7 |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
CDK7 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for CDK7:
Animal Models:
12 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Cdk7):
CDK7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CDK7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | RNA Polymerase I Chain Elongation | | | 3 | Global Genomic NER (GG-NER) | | | 4 | HIV Infection | | | 5 | Nucleotide Excision Repair | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for CDK7
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK7
1 
Cell Signaling Technology (CST) Pathway for CDK7
2  GeneGo (Thomson Reuters) Pathways for CDK7
5/6  BioSystems Pathways for CDK7 (see all 6)
5/58 
Reactome Pathways for CDK7 (see all 58)
3 
Kegg Pathways (Kegg details for CDK7):
CDK7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/172 Interacting proteins for CDK7 (P506132, 3 ENSP000002564434) via UniProtKB, MINT, STRING, and/or I2D (see all 172)About this table
Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000079 | regulation of cyclin-dependent protein kinase activity |
TAS | 7533895 | | GO:0000080 | G1 phase of mitotic cell cycle |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000086 | G2/M transition of mitotic cell cycle |
TAS | -- |
CDK7 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDK7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDK7 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CDK7 |
 Browse Tocris compounds for CDK7
2 HMDB Compounds for CDK7 About this table
2 DrugBank Compounds for CDK7 About this table
10/12 Novoseek chemical compound relationships for CDK7 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| roscovitine |
77.8 |
17 |
19911397 (2), 17942543 (2), 17901130 (1), 15308730 (1) (see all 8) |
| threonine |
56.7 |
18 |
8208544 (3), 11113184 (2), 8182057 (2), 7799941 (1) (see all 11) |
| 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole |
50.5 |
3 |
17047081 (1) |
| atp |
28.5 |
9 |
15530371 (1), 8060530 (1), 17386261 (1), 10866826 (1) (see all 5) |
| serine |
28.4 |
4 |
8208544 (3), 9696809 (1) |
| cyclic amp |
10.1 |
8 |
9774149 (3), 8647207 (1) |
| retinoic acid |
4.5 |
2 |
10748061 (1), 10896783 (1) |
| cgmp |
1.98 |
3 |
8384796 (2), 11514553 (1) |
| nitric oxide |
0 |
1 |
8384796 (1) |
| progesterone |
0 |
1 |
2209545 (1) |
Search CenterWatch for drugs/clinical trials and news about CDK7
|
Transcripts
for CDK7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDK7 gene: NM_001799.3 Unigene Cluster for CDK7: Cyclin-dependent kinase 7 Hs.184298 [show with all ESTs]Unigene Representative Sequence: NM_00179913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506563 ENST00000512687(uc010ixd.1) ENST00000256443(uc021xzo.1 uc003jvs.4 uc003jvt.4)
ENST00000515391 ENST00000512985 ENST00000515180 ENST00000506789 ENST00000510106
ENST00000514676 ENST00000504147 ENST00000508726 ENST00000502604 ENST00000513629
Inhib. RNA
Products: | | EMD Millipore RNAi Products for the Analysis of CDK7 Gene knock-down | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK7 (see all 4)
OriGene shRNA RFP: CDK7
OriGene siRNA: CDK7
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK7 |
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDK7 (NM_001799) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK7 |
Additional cDNA sequence: AK026509.1 AK308493.1 BC000834.2 BC005298.1 L20320.1 X77303.1 X77743.1 X79193.1 Y13120.1 13 DOTS entries: DT.445805 DT.100890371 DT.91732806 DT.95108778 DT.100835295 DT.100890386 DT.97846650 DT.91965922 DT.92027722 DT.120847977 DT.40117295 DT.91801854 DT.95331487 24/207 AceView cDNA sequences (see all 207): F02366 BP872612 AI017756 CR611671 BQ432504 BI831473 BC000834 CA310644 BM544823 BG820496 BQ776285 BU631128 BU069814 H94003 CD679101 CA305960 CA416765 CA423628 AA748836 X77303 CA435215 CN479963 BQ431198 BQ013338
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CDK7 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDK7
|
Expression
for CDK7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDK7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CDK7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK7
SOURCE GeneReport for Unigene cluster: Hs.184298
UniProtKB/Swiss-Prot: CDK7_HUMAN, P50613Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including CDK7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK7 |
Orthologs
for CDK7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CDK7 gene from 9/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDK71 |
cyclin-dependent kinase 7 |
79.59(n)
88.34(a) |
|
771294 XM_001234586.2 XP_001234587.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CDK76 |
-- |
88(a) |
1 ↔ 1 |
2(12403766-12414491) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.17682 |
Xenopus MO15 mRNA for 40 kDa protein kinase, cdc2-related |
80.14(n) |
|
X53962.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CK237063.12 |
-- |
78.88(n) |
|
CK237063.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cdk71 , 3 |
regulation of CDK activity protein
serine/threonine more3
Cyclin-dependent kinase 71 |
66(a)
(best of 2)3
61.11(n)1
67.54(a)1 |
|
4F43
314411 NM_078489.21 NP_511044.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
H01G02.23
cdk-71 |
serine/threonine kinase (2 domains)3
Protein CDK-71 |
40(a)3
59.27(n)1
60.93(a)1 |
|
IV(11798872-11801260)3
1717841 NM_058551.51 NP_490952.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
KIN28(YDL108W)4
KIN281 |
Serine/threonine protein kinase, subunit of the transcription more4
Kin28p1 |
54.4(n)1
49.31(a)1 |
|
4(267698-268699)4
8514501, 4 NP_010175.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CAK41 |
cyclin-dependent kinase D-2 |
58.04(n)
56.63(a) |
|
842993 NM_105345.4 NP_176847.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.26892 |
O.sativa mRNA for cdc2+/CDC28-related protein kinase |
71.44(n) |
|
X58194.1 |
ENSEMBL Gene Tree for CDK7 (if available)
TreeFam Gene Tree for CDK7 (if available) |
Paralogs
for CDK7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDK7 gene
- CDK202
18/100 SIMAP similar genes for CDK7 using alignment to 10 protein entries: CDK7_HUMAN (see all proteins)
(see all similar genes):CDK1 CDK18 CDC2 CSNK2A2 CDK3 DKFZp686L20222
DYRK4 DYRK1A CDK16 CDKL2 CDK11B CDK5
CDK11A CDK2 CDK4 CDC2L1 CDKL5 MAPK7
CDK7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CDK7
PGOHUM00000240398
|
Genomic Variants
for CDK7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDK7 (68530622 - 68573257 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDK7
1 CNV: 0283
Human Gene Mutation Database (HGMD): CDK7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK7 |
|
Disorders
/ Diseases
for CDK7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDK7 for disorders About GeneDecksing
OMIM gene information: 601955
OMIM disorders: --
20/27  diseases for CDK7 (see all 27): About MalaCardsphotosensitive trichthiodystrophy xeroderma pigmentosum cytomegalovirus infection herpes simplex
cockayne syndrome ovarian cancer colon carcinoma alzheimer's disease
multiple sclerosis hemangioma endometrial carcinoma nephropathy
lung cancer hepatitis b hepatoblastoma breast cancer
pulmonary disease glioblastoma carcinoma retinoblastoma
3 diseases from the University of Copenhagen DISEASES database for CDK7:Xeroderma pigmentosum Photosensitive trichothiodystrophy Cockayne syndrome 10/12 Novoseek disease relationships for CDK7 gene (see all 12) About this table
Genetic Association Database (GAD): CDK7
Human Genome Epidemiology (HuGE) Navigator: CDK7 (15 documents)
Export disorders for CDK7 gene to outside databases
|
Publications
for CDK7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDK7 gene, integrated from 9 sources (see all 304):
(articles sorted by number of sources associating them with CDK7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)1, 2, 3, 9 Fisher R.P. and Morgan D.O. (1994)
- Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. (PubMed id 7936635)1, 2, 9 Darbon J.-M.... Blanchard J.-M. (1994)
- Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PubMed id 8208544)1, 2, 9 Levedakou E.N.... Liu E.T. (1994)
- Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. (PubMed id 11113184)1, 2, 9 Garrett S....Fisher R.P. (2001)
- Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. (PubMed id 17386261)1, 2, 9 Larochelle S....Fisher R.P. (2007)
- Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). (PubMed id 7929589)1, 2, 9 Tassan J.-P.... Nigg E.A. (1994)
- CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs? (PubMed id 15876871)1, 2, 9 Lolli G. and Johnson L.N. (2005)
- p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. (PubMed id 9372954)1, 2, 9 Ko L.J....Pan Z.Q. (1997)
- TFIIH-associated Cdk7 kinase functions in phosphoryla tion of C-terminal domain Ser7 residues, promoter-proximal pausing, and termina tion by RNA polymerase II. (PubMed id 19667075)1, 2, 9 Glover-Cutter K....Bentley D.L. (2009)
- Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7. (PubMed id 17901130)1, 2, 9 Lewis A.E....Bakke M. (2008)
|
External Searches for CDK7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDK7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDK7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDK7 gene:
Search GeneIP for patents involving CDK7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDK7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for CDK7 | | OriGene shRNA RFP for CDK7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK7 | | | OriGene Protein Over-expression Lysate for CDK7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDK7 | | OriGene 3'-UTR Clone for CDK7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CDK7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDK7 | | OriGene Custom Protein Services for CDK7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK7 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK7 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK7 |
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