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Aliases for CDK6 Gene

Aliases for CDK6 Gene

  • Cyclin-Dependent Kinase 6 2 3 5
  • Serine/Threonine-Protein Kinase PLSTIRE 3 4
  • Cell Division Protein Kinase 6 3 4
  • EC 2.7.11.22 4 63
  • EC 2.7.11 63
  • PLSTIRE 3
  • MCPH12 3
  • CDKN6 4

External Ids for CDK6 Gene

Previous GeneCards Identifiers for CDK6 Gene

  • GC07M090779
  • GC07M091841
  • GC07M091855
  • GC07M091878
  • GC07M092072
  • GC07M092234
  • GC07M086843

Summaries for CDK6 Gene

Entrez Gene Summary for CDK6 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for CDK6 Gene

CDK6 (Cyclin-Dependent Kinase 6) is a Protein Coding gene. Diseases associated with CDK6 include microcephaly 12, primary, autosomal recessive and autosomal recessive primary microcephaly. Among its related pathways are Cellular Senescence and Cell Cycle, Mitotic. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK4.

UniProtKB/Swiss-Prot for CDK6 Gene

  • Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

Tocris Summary for CDK6 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK6 Gene

Genomics for CDK6 Gene

Regulatory Elements for CDK6 Gene

Transcription factor binding sites by QIAGEN in the CDK6 gene promoter:

Genomic Location for CDK6 Gene

Chromosome:
7
Start:
92,604,921 bp from pter
End:
92,836,627 bp from pter
Size:
231,707 bases
Orientation:
Minus strand

Genomic View for CDK6 Gene

Genes around CDK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK6 Gene

Proteins for CDK6 Gene

  • Protein details for CDK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00534-CDK6_HUMAN
    Recommended name:
    Cyclin-dependent kinase 6
    Protein Accession:
    Q00534
    Secondary Accessions:
    • A4D1G0

    Protein attributes for CDK6 Gene

    Size:
    326 amino acids
    Molecular mass:
    36938 Da
    Quaternary structure:
    • Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177 (By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposis sarcoma herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates NPM1 and thus lead to viral reactivation by reducing viral LANA levels.
    Miscellaneous:
    • Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients.
    • Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors, lymphoma and melanoma) as a consequence of nearby translocations.

    Three dimensional structures from OCA and Proteopedia for CDK6 Gene

neXtProt entry for CDK6 Gene

Proteomics data for CDK6 Gene at MOPED

Post-translational modifications for CDK6 Gene

  • Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
  • Ubiquitination at Lys 3, Lys 26, Lys 29, Lys 147, Lys 160, Lys 230, Lys 257, Lys 264, Lys 274, Lys 279, Lys 287, and Lys 307
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK6 (CDK6)

Domains & Families for CDK6 Gene

Gene Families for CDK6 Gene

Suggested Antigen Peptide Sequences for CDK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q00534

UniProtKB/Swiss-Prot:

CDK6_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK6: view

Function for CDK6 Gene

Molecular function for CDK6 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 6,cdc2 related gene family,involved in cell cycle regulation (G1 to S transition),complexing with cyclin D (D1,D2,D3)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991, 4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24 dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly down-regulated prior to cell differentiation (e.g. erythroid and osteoblast).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry.

Enzyme Numbers (IUBMB) for CDK6 Gene

Gene Ontology (GO) - Molecular Function for CDK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with CDK6: view
genes like me logo Genes that share phenotypes with CDK6: view

Human Phenotype Ontology for CDK6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDK6 Gene

MGI Knock Outs for CDK6:

Animal Model Products

miRNA for CDK6 Gene

miRTarBase miRNAs that target CDK6

No data available for Transcription Factor Targets and HOMER Transcription for CDK6 Gene

Localization for CDK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK6 Gene

Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250 UniProtKB:Q64261, ECO:0000269 PubMed:23918663}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK6 Gene COMPARTMENTS Subcellular localization image for CDK6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 17420273
GO:0005634 nucleus IDA 14985467
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDK6: view

Pathways & Interactions for CDK6 Gene

genes like me logo Genes that share pathways with CDK6: view

SIGNOR curated interactions for CDK6 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 16294322
GO:0001954 positive regulation of cell-matrix adhesion IDA 10205165
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006468 protein phosphorylation IEA,IDA 8114739
GO:0007050 cell cycle arrest TAS 16294322
genes like me logo Genes that share ontologies with CDK6: view

Drugs & Compounds for CDK6 Gene

(82) Drugs for CDK6 Gene - From: Novoseek, DGIdb, ClinicalTrials, HMDB, Tocris, ApexBio, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palbociclib Approved Pharma Inhibition, Target, Inhibitor 85
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 350
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Aromatase Inhibitors, Hormone therapy 262
Estradiol Approved, Investigational Pharma Sex hormone 1094
Everolimus Approved Pharma mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1797

(16) Additional Compounds for CDK6 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
10Z-Hymenialdisine
82005-12-7
genes like me logo Genes that share compounds with CDK6: view

Transcripts for CDK6 Gene

Unigene Clusters for CDK6 Gene

Cyclin-dependent kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK6 Gene

No ASD Table

Relevant External Links for CDK6 Gene

GeneLoc Exon Structure for
CDK6
ECgene alternative splicing isoforms for
CDK6

Expression for CDK6 Gene

mRNA expression in normal human tissues for CDK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8) and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK6 Gene



SOURCE GeneReport for Unigene cluster for CDK6 Gene Hs.119882

mRNA Expression by UniProt/SwissProt for CDK6 Gene

Q00534-CDK6_HUMAN
Tissue specificity: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.
genes like me logo Genes that share expression patterns with CDK6: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDK6 Gene

Orthologs for CDK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK6 35
  • 99.8 (n)
  • 100 (a)
CDK6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK6 36
  • 98 (a)
OneToOne
CDK6 35
  • 92.94 (n)
  • 97.55 (a)
dog
(Canis familiaris)
Mammalia CDK6 35
  • 92.64 (n)
  • 96.63 (a)
CDK6 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk6 16
E030030I06Rik 36
  • 23 (a)
OneToOne
Cdk6 35
  • 89.98 (n)
  • 96.32 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK6 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk6 35
  • 90.39 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves CDK6 36
  • 91 (a)
OneToOne
CDK6 35
  • 83.64 (n)
  • 91.1 (a)
lizard
(Anolis carolinensis)
Reptilia CDK6 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk6 35
  • 80.25 (n)
  • 87.04 (a)
Str.20309 35
zebrafish
(Danio rerio)
Actinopterygii cdk6 36
  • 80 (a)
OneToOne
cdk6 35
  • 74.2 (n)
  • 87.04 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005817 35
  • 53.56 (n)
  • 51.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdk4 35
  • 53.52 (n)
  • 46.71 (a)
Cdk4 37
  • 46 (a)
Cdk4 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-4 35
  • 51.01 (n)
  • 41.28 (a)
cdk-4 36
  • 29 (a)
ManyToMany
F52B5.2 36
  • 26 (a)
ManyToMany
cdk-4 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for CDK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK6 Gene

ENSEMBL:
Gene Tree for CDK6 (if available)
TreeFam:
Gene Tree for CDK6 (if available)

Paralogs for CDK6 Gene

Paralogs for CDK6 Gene

genes like me logo Genes that share paralogs with CDK6: view

Variants for CDK6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CDK6 Gene

Q00534-CDK6_HUMAN
Genetic variations in CDK6 may influence stature as a quantitative trait, contributing to the stature quantitative trait locus 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.

Sequence variations from dbSNP and Humsavar for CDK6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs8179 -- 92,606,850(-) GGTTC(A/G)CGTAG utr-variant-3-prime
rs42030 -- 92,607,107(+) GACAC(A/G)TTCTG utr-variant-3-prime
rs42031 -- 92,608,082(+) CTTTA(A/T)CCTAA utr-variant-3-prime
rs42032 -- 92,608,112(+) CTAGG(A/G)ACCAC utr-variant-3-prime
rs42033 -- 92,608,219(+) TTGAG(A/T)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK6 Gene

Variant ID Type Subtype PubMed ID
nsv819408 CNV Gain 19587683
nsv831062 CNV Gain 17160897
nsv516592 CNV Gain+Loss 19592680
nsv888736 CNV Loss 21882294

Variation tolerance for CDK6 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK6 Gene

HapMap Linkage Disequilibrium report
CDK6
Human Gene Mutation Database (HGMD)
CDK6

Disorders for CDK6 Gene

MalaCards: The human disease database

(21) MalaCards diseases for CDK6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microcephaly 12, primary, autosomal recessive
  • primary autosomal recessive microcephaly type 12
autosomal recessive primary microcephaly
  • mcph
microcephaly, postnatal progressive, with seizures and brain atrophy
  • mcphsba
microcephaly, short stature, and impaired glucose metabolism
  • microcephaly, short stature, and impaired glucose metabolism 1
endometrial squamous cell carcinoma
  • squamous cell carcinoma of endometrium
- elite association - COSMIC cancer census association via MalaCards
Search CDK6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK6_HUMAN
  • Microcephaly 12, primary, autosomal recessive (MCPH12) [MIM:616080]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO:0000269 PubMed:23918663}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDK6

Genetic Association Database (GAD)
CDK6
Human Genome Epidemiology (HuGE) Navigator
CDK6
Tumor Gene Database (TGDB):
CDK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK6
genes like me logo Genes that share disorders with CDK6: view

No data available for Genatlas for CDK6 Gene

Publications for CDK6 Gene

  1. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 2 3 4 67
  2. Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a. (PMID: 20331971) Yoshioka H. … Sugimoto Y. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. (PMID: 20086245) Zhao J.J. … Cheng J.Q. (Blood 2010) 3 23
  4. Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders. (PMID: 19145199) Chen D. … Dogan A. (Am. J. Surg. Pathol. 2009) 3 23
  5. Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. (PMID: 19435910) Agirre X. … PrA^sper F. (Cancer Res. 2009) 3 23

Products for CDK6 Gene

Sources for CDK6 Gene

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