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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK6 Gene

protein-coding   GIFtS: 70
GCID: GC07M092234

cyclin-dependent kinase 6
 Explore 89 diseases affiliated with
CDK6 via
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 Human Malady Compendium 
Biological research products
for CDK6    

Aliases
for CDK6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 61 2     EC 2.7.11.223 8
PLSTIRE1 2 5     CDKN63
Cell Division Protein Kinase 62 3     EC 2.7.118
Serine/Threonine-Protein Kinase PLSTIRE2 3     

External Ids:    HGNC: 17771   Entrez Gene: 10212   Ensembl: ENSG000001058107   OMIM: 6033685   UniProtKB: Q005343   

Export aliases for CDK6 gene to outside databases

Previous GC identifers: GC07M090779 GC07M091841 GC07M091855 GC07M091878 GC07M092072 GC07M086843


Summaries
for CDK6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK6:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members
are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are
known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase
complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first
appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4
family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the
activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple
alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S
transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a
pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle
exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is
required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell
proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles.
Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length.
Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including
loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by
interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal
myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans

summary for CDK6:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK6 (Cyclin-dependent kinase 6)


Genomic Views
for CDK6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK6 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CDK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21-q22

CDK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092234:  view genomic region     (about GC identifiers)

Start:
 92,234,235 bp from pter      End:
 92,465,941 bp from pter
Size:
 231,707 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 91,563,451-91,795,159     

Proteins
for CDK6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 6  
Size: 326 amino acids; 36938 Da
Subunit: Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177
(By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1
and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma herpesvirus (KSHV) V-cyclin
and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates NPM1 and thus lead to viral
reactivation by reducing viral LANA levels
Subcellular location: Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of spreading
fibroblasts. Kinase activity only in nucleus
Miscellaneous: Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors, lymphoma
and melanoma) as a consequence of nearby translocations
Miscellaneous: Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients
6/12 PDB 3D structures from and Proteopedia for CDK6 (see all 12):
1BI7 (3D)        1BI8 (3D)        1BLX (3D)        1G3N (3D)        1JOW (3D)        1XO2 (3D)    

Explore the universe of human proteins at neXtProt for CDK6: NX_Q00534

Post-translational modifications:

  • Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q00534

    • 4/11 DME Specific Peptides for CDK6 (Q00534) (see all 11)
     HPNVVRL  LADFGLA  VVHRDLK  RTDRETK 

    CDK6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138778.1  NP_001250.1  

    ENSEMBL proteins: 
     ENSP00000265734   ENSP00000397087  
    Reactome Protein details: Q00534
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CDK6 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CDK6
    OriGene Protein Over-expression Lysate (see all 2): CDK6
    OriGene Custom Protein Services for CDK6 
    GenScript Custom Purified and Recombinant Proteins Services for CDK6
    Novus Biologicals CDK6 Proteins
    Novus Biologicals CDK6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDK6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0001726ruffle IDA10205165
    GO:0005634nucleus IDA14985467
    GO:0005737cytoplasm IDA14985467
    GO:0005829cytosol TAS--


    CDK6 for ontologies           About GeneDecksing



    CDK6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK6
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDK6 
    OriGene Antibodies: CDK6
    OriGene Custom Antibody Services for CDK6 
    GenScript Superior Antibodies for CDK6
    Novus Biologicals CDK6 Antibodies
    Abcam antibodies for CDK6 
    Uscn Antibodies for CDK6
    ThermoFisher Antibody for CDK6

    Assay Products for CDK6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDK6

    Protein Domains /
    Families
    for CDK6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK6 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q00534

    ProtoNet protein and cluster: Q00534

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S
    transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a
    pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle
    exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is
    required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell
    proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles.
    Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length.
    Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including
    loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by
    interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal
    myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991,
    4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24
    dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly
    down-regulated prior to cell differentiation (e.g. erythroid and osteoblast)
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry

         Genatlas biochemistry entry for CDK6:
    cyclin dependent kinase 6,cdc2 related gene family,involved in cell cycle regulation (G1 to S transition),complexing
    with cyclin D (D1,D2,D3)

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target CDK6:
    hsa-mir-30a (MIRT001760), hsa-mir-124 (MIRT002642), hsa-mir-203 (MIRT004723), hsa-mir-29c (MIRT003200), hsa-mir-424 (MIRT000938), hsa-mir-29a (MIRT000682), hsa-mir-107 (MIRT001233), hsa-mir-16 (MIRT000939), hsa-mir-185 (MIRT004700), hsa-let-7b (MIRT002297), mmu-mir-124 (MIRT001014), mmu-mir-137 (MIRT001015), hsa-mir-29b (MIRT000684), hsa-mir-137 (MIRT002490), hsa-mir-34b (MIRT003579), hsa-mir-449a (MIRT003187), hsa-mir-34b (MIRT000762), hsa-mir-34a (MIRT001012)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK6
    8/166 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK6 (see all 166):
    hsa-miR-106a hsa-miR-342-3p hsa-miR-3921 hsa-miR-502-3p hsa-miR-298 hsa-miR-149 hsa-miR-3116 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK6 (see all 4)
    OriGene shRNA RFP: CDK6
    OriGene siRNA: CDK6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK6 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK6 (NM_001259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK6
    Search LifeMap BioReagents cell lines for CDK6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK6

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004693cyclin-dependent protein kinase activity IDA8114739
    GO:0005515protein binding IPI8001816
    GO:0005524ATP binding IDA9751050
    GO:0016301kinase activity ----
    GO:0030332cyclin binding IPI8114739


    CDK6 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for CDK6:
     Decreased mitotic index  Decreased substrate adherent c  Increased apoptosis  Increased circadian period len 
     Synthetic lethal/sick with VHL  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Cdk6tm1Bbd for CDK6
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdk6):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  immune system  liver/biliary system  mortality/aging  muscle 
     reproductive system  tumorigenesis 

    CDK6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDK6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell cycle_Cell cycle (generic schema)
    		Cell cycle_Cell cycle (generic schema)1.00
    		Cell cycle_Regulation of G1/S transition (part 2)0.38
    		Cell cycle Cell cycle (generic schema)1.00
    		Cell cycle Regulation of G1/S transition (part 2)0.38
    2Cyclins and Cell Cycle Regulation
    		Cyclins and Cell Cycle Regulation1.00
    		Cyclin D associated events in G10.32
    		G1-S Phase Transition0.67
    		G1 Phase0.32
    3Glioma
    		Glioma1.00
    		Melanoma0.43
    		Non-small cell lung cancer0.53
    		Signaling Pathways in Glioblastoma0.36
    4Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57
    5Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for CDK6
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Cell cycle (generic schema)

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK6 (see all 8)
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    HGF Pathway
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics

    1 Cell Signaling Technology (CST) Pathway for CDK6
        Cell Cycle / Checkpoint Control

    4 GeneGo (Thomson Reuters) Pathways for CDK6
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Cell cycle (generic schema)

    5/10 BioSystems Pathways for CDK6 (see all 10) 
        G1 to S cell cycle control
    DNA damage response
    miRNAs involved in DDR
    Signaling Pathways in Glioblastoma
    Cell cycle

    5        Reactome Pathways for CDK6
        G1 Phase
    Mitotic G1-G1/S phases
    Cell Cycle
    Cell Cycle, Mitotic
    Cyclin D associated events in G1


    5/10         Kegg Pathways  (Kegg details for CDK6) (see all 10):
        Cell cycle
    p53 signaling pathway
    Measles
    Pathways in cancer
    Pancreatic cancer


    CDK6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for CDK6 (Q005341, 2, 3 ENSP000002657344) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AP427711, 2, 3, ENSP000003551534I2D: score=2 EBI-295663,EBI-375053 MINT-25084 I2D: score=4 STRING: ENSP00000355153
    CCND3P302811, 2, 3, ENSP000003620824EBI-295663,EBI-375013 MINT-50439 I2D: score=8 STRING: ENSP00000362082
    RUNX1Q011962, 3, ENSP000003003054MINT-4791080 MINT-4791148 MINT-4791064 MINT-4791100 I2D: score=2 STRING: ENSP00000300305
    ATXN1P542532, 3, ENSP000002447694MINT-2857450 I2D: score=3 STRING: ENSP00000244769
    CCND1P243851, 2, 3, ENSP000002275074EBI-295663,EBI-375001 MINT-50434 I2D: score=7 STRING: ENSP00000227507
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS16294322
    GO:0000278mitotic cell cycle TAS--
    GO:0001954positive regulation of cell-matrix adhesion IDA10205165
    GO:0002244hematopoietic progenitor cell differentiation IEA--


    CDK6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK6 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK6:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CDK6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ApigeninProtein kinase inhibitor[520-36-5]

    2 HMDB Compounds for CDK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for CDK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL-- --target--10592235
    3,7,3',4'-TETRAHYDROXYFLAVONE-- --target--10592235
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    10/45 Novoseek chemical compound relationships for CDK6 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indole-3-carbinol 77 41 11297539 (9), 9461564 (6), 12840223 (4), 10808405 (1) (see all 6)
    3,3'-diindolylmethane 62 1 15661811 (1)
    silicon phthalocyanine 59 1 10086343 (1)
    eb 1089 53.3 5 10639575 (3), 10640426 (1), 11836565 (1)
    fisetin 37.8 4 15689157 (2), 17387141 (2)
    silymarin 35.2 3 9581834 (1), 9563902 (1)
    roscovitine 34.3 2 18003885 (1), 15741232 (1)
    17-(allylamino)-17-demethoxygeldanamycin 34 2 16267832 (1), 17157164 (1)
    indole 33.8 3 9461564 (1), 10808405 (1)
    lovastatin 33.6 2 10652602 (2)

    Search CenterWatch for drugs/clinical trials and news about CDK6 

    Transcripts
    for CDK6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK6 gene (2 alternative transcripts): 
    NM_001145306.1  NM_001259.6  

    Unigene Cluster for CDK6:

    Cyclin-dependent kinase 6
    Hs.119882  [show with all ESTs]
    Unigene Representative Sequence: NM_001145306
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265734(uc011khw.2 uc010lez.3) ENST00000467166 ENST00000424848
    ENST00000473078 ENST00000491250

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    8/166 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK6 (see all 166):
    hsa-miR-106a hsa-miR-342-3p hsa-miR-3921 hsa-miR-502-3p hsa-miR-298 hsa-miR-149 hsa-miR-3116 hsa-miR-92b
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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDK6 (NM_001259)
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    Additional cDNA sequence: 

    AB073601.1 AK000660.1 AK055922.1 AK172791.1 AK313491.1 BC012914.1 BC027989.1 BC052264.1 
    BC063591.1 BC065026.1 X66365.1 

    14 DOTS entries:

    DT.101972926  DT.452094  DT.99984557  DT.100794931  DT.95079372  DT.445352  DT.95130246  DT.95279996 
    DT.40229358  DT.40297680  DT.91689778  DT.92436499  DT.95280002  DT.97797884 

    24/406 AceView cDNA sequences (see all 406):

    AI270066 AW028098 AA305894 AW665776 AA861615 AI738486 AA262986 N90004 
    BM463226 BM718299 BM456929 BQ007888 AA347089 BQ675692 BM783431 AI023175 
    AK055922 Z41608 AI193926 AI739094 BM473949 AA604274 AA587695 BM771569 

    GeneLoc Exon Structure


    Expression
    for CDK6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGAAAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK6

    SOURCE GeneReport for Unigene cluster: Hs.119882

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Tissue specificity: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic
    progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating
    cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK6: 
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CDK6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CDK6 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDK61 cyclin-dependent kinase 6 83.44(n)
    91.1(a)    		   420558  NM_001007892.1  NP_001007893.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK66
    		 --
    		 88(a)
    		 1 ↔ 1
    		 6(21330537-21411210)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.203092 Transcribed sequence with strong similarity to protein pirS23387 (H.sapiens) S23387 protein kinase (EC 2.7.1.37) cdk6 - human less 87.29(n)    AL783887.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk61 cyclin-dependent kinase 6 74.5(n)
    87.69(a)    		   100034507  NM_001144053.1  NP_001137525.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdk41 , 3 cell proliferation protein serine/threonine
    kinase less3
    Cyclin-dependent kinase 41    		 46(a)3
    53.59(n)1
    46.87(a)1    		   2 53C93
    368541  NM_166184.11  NP_725594.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cdk-41 , 3 serine/threonine kinase (CDC2/CDKX
    subfamily)3
    Protein CDK-41    		 40(a)3
    51.01(n)1
    41.28(a)1    		   X(13551275-13552978)3
    1814721  NM_077855.41  NP_510256.11 


    ENSEMBL Gene Tree for CDK6 (if available)
    TreeFam Gene Tree for CDK6 (if available) 

    Paralogs
    for CDK6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK6 gene
    CDK182  CDK52  CDK152  CDK42  CDK12  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/57 SIMAP similar genes for CDK6 using alignment to 2 protein entries:     CDK6_HUMAN (see all proteins) (see all similar genes):
    CDK4    CDC2    CDK1    CDK3    CDC2L1    CDK11B
    DKFZp686L20222    CDC2L2    CDK11A    CDK14    CDK5    CDK7
    CDK15    CDK20    CDK17    CDK18    CDK9    CDK10

    CDK6 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Polymorphism: Genetic variations in CDK6 may influence stature as a quantitative trait, contributing to the stature
    quantitative trait locus 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly heritable complex
    continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits


    10/2967 NCBI SNPs in CDK6 are shown (see all 2967)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs774981111,2
    		C,--91562971(+) GAGTTC/TTTTTT 2 -- ds50010--------
    rs797444051,2
    		C,--91563157(+) AGACAC/TAGGGT 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs119791591,2
    		H--91563256(+) gagccA/Cccgtg 2 -- ds50010--------
    rs119792171,2
    		C,H--91563403(+) GAAGCA/CCCaaa 2 -- ds50010--------
    rs119793481,2
    		C,H--91563871(+) ACACCA/CCTGCA 2 -- ut31 ese32Minor allele frequency- C:0.00NA 4
    rs78065711,2
    		A--91563983(+) AAAACC/TAGATT 2 -- ut310--------
    rs78105461,2
    		C,A,H,--91564041(+) TTTACG/ATTACA 2 -- ut31 ese35Minor allele frequency- A:0.00NS EA WA 518
    rs78101951,2
    		A--91564090(+) AGGGTA/CTAGAT 2 -- ut310--------
    rs78109561,2
    		A,H--91564332(+) AATAGG/TTAGGA 2 -- ut31 ese34Minor allele frequency- T:0.00NS EA 412
    rs77939501,2
    		A--91564349(+) TTGCTC/TTCAGA 2 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for CDK6 (92234235 - 92465941 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CDK6
         2 CNVs: 94691 52311
         1 Indel: 59428

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing CDK6:
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    Disorders / Diseases
    for CDK6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK6 for disorders           About GeneDecksing

    OMIM gene information: 603368    OMIM disorders: --

    20/89 diseases for CDK6 (see all 89):    About MalaCards
    splenic marginal zone lymphoma    leukemia    melanoma    human t-cell leukemia virus type 1
    gastroesophageal junction adenocarcinoma    dna topoisomerase i    anaplastic large cell lymphoma    testicular germ cell tumor
    inverted papilloma    non-hodgkin lymphoma    soft tissue sarcoma    germ cell tumor
    wegener's granulomatosis    myelomonocytic leukemia    pediatric crohns disease    burkitt's lymphoma
    chronic myelomonocytic leukemia    kaposi's sarcoma    cutaneous malignant melanoma    adenoid cystic carcinoma

    1 disease from the University of Copenhagen DISEASES database for CDK6:
    Retinoblastoma

    10/40 Novoseek disease relationships for CDK6 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 88.1 82 18305152 (2), 19145199 (2), 11804329 (2), 9488660 (2) (see all 69)
    cancer 57.4 11 9177281 (1), 10475236 (1), 11676482 (1), 18391952 (1) (see all 11)
    tumors 56.6 58 15723654 (3), 18497076 (3), 10475236 (2), 14985467 (2) (see all 44)
    leukemia t-cell 51.9 1 9422538 (1)
    multiple tumors 39.8 1 9698532 (1)
    lymphoma 38.1 9 10597225 (2), 9422538 (1), 10879740 (1), 20086245 (1) (see all 5)
    glioblastoma 37.1 6 19188159 (1), 8806696 (1), 10884881 (1)
    breast cancer 37 17 9461564 (3), 11297539 (2), 12840223 (1), 12834607 (1) (see all 9)
    melanoma 35.7 11 10777219 (3), 17909018 (2), 8668202 (1), 10721488 (1) (see all 7)
    t-all 34.7 2 19001083 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDK6 (34 documents)
    Tumor Gene Database (TGDB): CDK6

    Export disorders for CDK6 gene to outside databases

    Publications
    for CDK6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK6 gene, integrated from 9 sources (see all 603):
    (articles sorted by number of sources associating them with CDK6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (1992)
    2. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PubMed id 17431401)1, 2, 9 Fujimoto T....Nerlov C. (2007)
    3. Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. (PubMed id 14985467)1, 2, 9 Lucas J.J....Gelfand E.W. (2004)
    4. Structural basis for CDK6 activation by a virus-encoded cyclin. (PubMed id 11828325)1, 2, 9 Schulze-Gahmen U. and Kim S.H. (2002)
    5. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. (PubMed id 8114739)1, 2, 9 Meyerson M. and Harlow E. (1994)
    6. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. (PubMed id 17420273)1, 2, 9 Ruas M....Peters G. (2007)
    7. Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. (PubMed id 11124804)1, 2, 9 Jeffrey P.D....Pavletich N.P. (2000)
    8. Nucleophosmin phosphorylation by v-cyclin-CDK6 contro ls KSHV latency. (PubMed id 20333249)1, 2 Sarek G....Ojala P.M. (2010)
    9. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    10. Beyond the cell cycle: a new role for Cdk6 in differe ntiation. (PubMed id 16294322)1, 2 Grossel M.J. and Hinds P.W. (2006)

    External Searches for CDK6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1021 HGNC: 1777 AceView: CDK6 Ensembl:ENSG00000105810 euGenes: HUgn1021
    ECgene: CDK6 Kegg: 1021 H-InvDB: CDK6

    Other Databases showing CDK6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk6/

    Intellectual Property
    for CDK6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK6 gene:
    Search GeneIP for patents involving CDK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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