Aliases for CDK6 Gene
Aliases for CDK6 Gene
External Ids for CDK6 Gene
- HGNC: 1777
- Entrez Gene: 1021
- Ensembl: ENSG00000105810
- OMIM: 603368
- UniProtKB: Q00534
Previous GeneCards Identifiers for CDK6 Gene
- GC07M090779
- GC07M091841
- GC07M091855
- GC07M091878
- GC07M092072
- GC07M092234
- GC07M086843
Summaries for CDK6 Gene
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The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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CDK6, along with its partner CDK4, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors.
GeneCards Summary for CDK6 Gene
CDK6 (Cyclin Dependent Kinase 6) is a Protein Coding gene. Diseases associated with CDK6 include Microcephaly 12, Primary, Autosomal Recessive and Autosomal Recessive Primary Microcephaly. Among its related pathways are Cellular Senescence and Cyclins and Cell Cycle Regulation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK4.
UniProtKB/Swiss-Prot for CDK6 Gene
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Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
-
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK6 Gene
Genomics for CDK6 Gene
Regulatory Elements for CDK6 Gene
Enhancers for CDK6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CDK6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CDK6 gene promoter:
Regulatory Element Products
Genomic Location for CDK6 Gene
- Chromosome:
- 7
- Start:
- 92,604,921 bp from pter
- End:
- 92,836,627 bp from pter
- Size:
- 231,707 bases
- Orientation:
- Minus strand
Genomic View for CDK6 Gene
Genes around CDK6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.2 by Ensembl
- 7q21.2 by Entrez Gene
- 7q21.2 by HGNC
CDK6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK6 Gene
Proteins for CDK6 Gene
-
Protein details for CDK6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00534-CDK6_HUMAN
- Recommended name:
- Cyclin-dependent kinase 6
- Protein Accession:
- Q00534
- A4D1G0
Protein attributes for CDK6 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 36938 Da
- Quaternary structure:
-
- Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177 (By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposis sarcoma herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates NPM1 and thus lead to viral reactivation by reducing viral LANA levels.
- Miscellaneous:
-
- Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients.
- Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors, lymphoma and melanoma) as a consequence of nearby translocations.
Protein Expression for CDK6 Gene
Selected DME Specific Peptides for CDK6 Gene
- Q00534:
-
- GCIFAEM
- WSVGCIFAE
- TLVFEHVDQDL
- HPNVVRL
- VVHRDLK
- VVTLWYR
- LADFGLA
- WSVGCIFAEMFRRKPLF
- RTDRETK
- HRDLKPQN
- VHRDLKP
Post-translational modifications for CDK6 Gene
- Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
- Ubiquitination at posLast=33, posLast=2626, Lys29, posLast=147147, posLast=160160, Lys230, Lys257, posLast=264264, Lys274, Lys279, posLast=287287, and posLast=307307
- Modification sites at PhosphoSitePlus
Other Protein References for CDK6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CDK6
- Cell Signaling Technology (CST) Antibodies for CDK6 (CDK6)
- Novus Biologicals Antibodies for CDK6
-
Abcam antibodies for CDK6
- Invitrogen Antibodies for CDK6
- antibodies-online Antibodies for CDK6: See all 253
- GeneTex CDK6 antibody for CDK6
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK6
Protein Products
- EMD Millipore Purified and/or Recombinant CDK6 Protein
-
OriGene Purified Proteins for CDK6
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK6
- Origene Custom Protein Services for CDK6
- antibodies-online Proteins for CDK6: See all 15
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CDK6
-
ProSci Proteins for CDK6
-
Abcam proteins for CDK6
Assay Products
- antibodies-online Kits for CDK6: See all 9
Domains & Families for CDK6 Gene
Gene Families for CDK6 Gene
- HGNC:
- IUPHAR :
Protein Domains for CDK6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q00534UniProtKB/Swiss-Prot:
CDK6_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK6 Gene
Molecular function for CDK6 Gene
- GENATLAS Biochemistry:
- cyclin dependent kinase 6,cdc2 related gene family,involved in cell cycle regulation (G1 to S transition),complexing with cyclin D (D1,D2,D3)
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991, 4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24 dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly down-regulated prior to cell differentiation (e.g. erythroid and osteoblast).
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry.
Enzyme Numbers (IUBMB) for CDK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IDA | 8114739 |
| GO:0005515 | protein binding | IPI | 8001816 |
Phenotypes for CDK6 Gene
- MGI mutant phenotypes for CDK6:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CDK6:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased substrate adherent cell growth
- Decreased IL-8 secretion
- Increased shRNA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased circadian period length
- Decreased cell number
- Increased mitotic index
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Apoptosis resistance
- Decreased IL-13 protein expression
- Decreased viability after gemcitabine stimulation
- Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line
Animal Models for CDK6 Gene
- MGI Knock Outs for CDK6:
-
- Cdk6 tm1Bbd
Animal Model Products
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Taconic Biosciences Mouse Models for CDK6
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK6 gene
- Search ViGene Biosciences for CDK6
CRISPR Products
-
OriGene CRISPR knockouts for CDK6
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK6
- GenScript: Design CRISPR guide RNA sequences for CDK6
miRNA for CDK6 Gene
- miRTarBase miRNAs that target CDK6
-
- hsa-mir-195-5p (MIRT000224)
- hsa-let-7a-5p (MIRT000415)
- hsa-mir-29a-3p (MIRT000682)
- hsa-mir-29b-3p (MIRT000684)
- hsa-mir-34b-5p (MIRT000762)
- hsa-mir-424-5p (MIRT000938)
- hsa-mir-16-5p (MIRT000939)
- hsa-mir-34a-5p (MIRT001012)
- mmu-mir-124-3p (MIRT001014)
- mmu-mir-137-3p (MIRT001015)
- hsa-mir-107 (MIRT001233)
- hsa-mir-30a-3p (MIRT001760)
- hsa-let-7b-5p (MIRT002297)
- hsa-mir-21-5p (MIRT002406)
- hsa-mir-137 (MIRT002490)
- hsa-mir-124-3p (MIRT002642)
- hsa-mir-449a (MIRT003187)
- hsa-mir-29c-3p (MIRT003200)
- hsa-mir-34b-3p (MIRT003579)
- hsa-mir-34c-5p (MIRT004573)
- hsa-mir-185-5p (MIRT004700)
- hsa-mir-203a-3p (MIRT004723)
- hsa-mir-494-3p (MIRT006112)
- hsa-mir-26a-5p (MIRT006306)
- hsa-mir-26b-5p (MIRT006307)
- hsa-mir-191-5p (MIRT006721)
- hsa-mir-218-5p (MIRT007145)
- hsa-mir-449b-5p (MIRT016139)
- hsa-mir-193b-3p (MIRT016513)
- hsa-mir-103a-3p (MIRT027234)
- hsa-mir-22-3p (MIRT030654)
- hsa-mir-1303 (MIRT035884)
- hsa-mir-615-3p (MIRT040000)
- hsa-mir-512-5p (MIRT053428)
- hsa-mir-452-5p (MIRT053452)
- hsa-mir-378a-3p (MIRT053508)
- hsa-mir-129-5p (MIRT053575)
- hsa-mir-129-2-3p (MIRT053576)
- hsa-mir-145-5p (MIRT054379)
- hsa-mir-506-3p (MIRT054621)
- hsa-mir-513a-3p (MIRT104444)
- hsa-mir-670-3p (MIRT104446)
- hsa-mir-513c-3p (MIRT104447)
- hsa-mir-3606-3p (MIRT104448)
- hsa-mir-6757-3p (MIRT104450)
- hsa-mir-561-5p (MIRT104455)
- hsa-mir-4761-5p (MIRT104460)
- hsa-mir-6801-5p (MIRT104461)
- hsa-mir-3941 (MIRT123783)
- hsa-mir-8485 (MIRT123788)
- hsa-mir-147a (MIRT123790)
- hsa-mir-1298-5p (MIRT223089)
- hsa-mir-551b-5p (MIRT258542)
- hsa-mir-140-3p (MIRT321431)
- hsa-mir-384 (MIRT321450)
- hsa-mir-5682 (MIRT321455)
- hsa-mir-216b-5p (MIRT362970)
- hsa-mir-548v (MIRT372073)
- hsa-mir-1179 (MIRT379031)
- hsa-mir-4310 (MIRT379032)
- hsa-mir-4291 (MIRT379033)
- hsa-mir-7157-5p (MIRT379036)
- hsa-mir-1236-3p (MIRT393089)
- hsa-mir-214-3p (MIRT393091)
- hsa-mir-761 (MIRT393094)
- hsa-mir-922 (MIRT393095)
- hsa-mir-3619-5p (MIRT393096)
- hsa-mir-6809-3p (MIRT396148)
- hsa-mir-373-5p (MIRT402358)
- hsa-mir-616-5p (MIRT402360)
- hsa-mir-371b-5p (MIRT402369)
- hsa-mir-371a-5p (MIRT402377)
- hsa-mir-372-5p (MIRT402378)
- hsa-mir-3671 (MIRT402379)
- hsa-mir-504-5p (MIRT438313)
- hsa-mir-200a-3p (MIRT438675)
- hsa-mir-105-5p (MIRT438854)
- hsa-mir-205-5p (MIRT440963)
- hsa-mir-4256 (MIRT479445)
- hsa-mir-6836-5p (MIRT479446)
- hsa-mir-6821-3p (MIRT479447)
- hsa-mir-6132 (MIRT479448)
- hsa-mir-6790-3p (MIRT479449)
- hsa-mir-4750-3p (MIRT479450)
- hsa-mir-301b-5p (MIRT479451)
- hsa-mir-301a-5p (MIRT479452)
- hsa-mir-4714-5p (MIRT479453)
- hsa-mir-15b-5p (MIRT479454)
- hsa-mir-497-5p (MIRT479455)
- hsa-mir-6838-5p (MIRT479456)
- hsa-mir-15a-5p (MIRT479457)
- hsa-mir-498 (MIRT479458)
- hsa-mir-2054 (MIRT479459)
- hsa-mir-3915 (MIRT479460)
- hsa-mir-644a (MIRT479461)
- hsa-mir-3911 (MIRT479462)
- hsa-mir-891a-3p (MIRT479463)
- hsa-mir-3688-5p (MIRT479464)
- hsa-mir-3928-3p (MIRT479465)
- hsa-mir-3922-5p (MIRT479466)
- hsa-mir-4717-5p (MIRT479467)
- hsa-mir-449c-5p (MIRT479468)
- hsa-mir-2682-5p (MIRT479469)
- hsa-mir-4753-5p (MIRT479470)
- hsa-mir-8054 (MIRT479471)
- hsa-mir-548k (MIRT479472)
- hsa-mir-548av-5p (MIRT479473)
- hsa-mir-5587-5p (MIRT507810)
- hsa-mir-7853-5p (MIRT507811)
- hsa-mir-7849-3p (MIRT507812)
- hsa-mir-5197-5p (MIRT507813)
- hsa-mir-302c-5p (MIRT538591)
- hsa-mir-302d-5p (MIRT538592)
- hsa-mir-302b-5p (MIRT538593)
- hsa-mir-7152-5p (MIRT538594)
- hsa-mir-183-3p (MIRT538595)
- hsa-mir-4326 (MIRT538596)
- hsa-mir-4680-3p (MIRT538597)
- hsa-mir-1266-3p (MIRT538598)
- hsa-mir-4724-5p (MIRT538599)
- hsa-mir-548c-3p (MIRT548925)
- hsa-mir-4753-3p (MIRT558804)
- hsa-mir-885-3p (MIRT558805)
- hsa-mir-942-5p (MIRT558806)
- hsa-mir-6868-5p (MIRT558807)
- hsa-mir-6515-3p (MIRT558808)
- hsa-mir-222-3p (MIRT562519)
- hsa-mir-221-3p (MIRT562520)
- hsa-mir-187-5p (MIRT562521)
- hsa-mir-6782-3p (MIRT562522)
- hsa-mir-491-3p (MIRT562523)
- hsa-mir-3613-5p (MIRT562524)
- hsa-mir-219a-2-3p (MIRT562525)
- hsa-mir-5739 (MIRT562526)
- hsa-mir-5091 (MIRT562527)
- hsa-mir-6716-3p (MIRT562528)
- hsa-mir-502-3p (MIRT562529)
- hsa-mir-501-3p (MIRT562530)
- hsa-mir-646 (MIRT572183)
- hsa-mir-8064 (MIRT608619)
- hsa-mir-4643 (MIRT608620)
- hsa-mir-603 (MIRT613208)
- hsa-mir-362-3p (MIRT613209)
- hsa-mir-329-3p (MIRT613210)
- hsa-mir-888-5p (MIRT615975)
- hsa-mir-302f (MIRT659636)
- hsa-mir-342-3p (MIRT659637)
- hsa-mir-3685 (MIRT669091)
- hsa-mir-607 (MIRT669092)
- hsa-mir-155-3p (MIRT669093)
- hsa-mir-548n (MIRT672433)
- hsa-mir-1972 (MIRT688756)
- hsa-mir-624-5p (MIRT688757)
- hsa-mir-500b-3p (MIRT704789)
- hsa-mir-3159 (MIRT704790)
- hsa-mir-6871-3p (MIRT704791)
- hsa-mir-4482-5p (MIRT704792)
- hsa-mir-3130-5p (MIRT704793)
- hsa-mir-541-5p (MIRT704794)
- hsa-mir-5195-3p (MIRT704795)
miRNA Products
- Search ViGene Biosciences for CDK6
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CDK6
- Browse OriGene Inhibitory RNA Products For CDK6
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CDK6
- VectorBuilder custom plasmid, inducible vectors for CDK6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK6
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VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CDK6
-
ViGene Biosciences adenoviral particle packaged cDNA for CDK6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK6 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for CDK6 Gene
Localization for CDK6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK6 Gene
- Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250 UniProtKB:Q64261, ECO:0000269 PubMed:23918663}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IDA | 17420273 |
| GO:0001726 | ruffle | IDA | 10205165 |
| GO:0005634 | nucleus | IDA | 14985467 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 14985467 |
Pathways & Interactions for CDK6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glioma |
.47
.41
|
.36
|
| 2 | Cyclins and Cell Cycle Regulation |
.31
|
|
| 3 | Cellular Senescence | ||
| 4 | DNA Damage Response | ||
| 5 | Cell cycle |
.58
|
.58
|
Pathways by source for CDK6 Gene
1 GeneTex pathway for CDK6 Gene
1 Cell Signaling Technology pathway for CDK6 Gene
12 BioSystems pathways for CDK6 Gene
10 Reactome pathways for CDK6 Gene
15 KEGG pathways for CDK6 Gene
4 GeneGo (Thomson Reuters) pathways for CDK6 Gene
Interacting Proteins for CDK6 Gene
Selected Interacting proteins:
Q00534-CDK6_HUMAN
ENSP00000265734
for CDK6 Gene via
MINT
STRING
IID
UniProtKB
SIGNOR curated interactions for CDK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | 16294322 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0001954 | positive regulation of cell-matrix adhesion | IDA | 10205165 |
| GO:0003323 | type B pancreatic cell development | IDA | 20668294 |
| GO:0006468 | protein phosphorylation | IDA | 8114739 |
Drugs & Compounds for CDK6 Gene
(93) Drugs for CDK6 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Palbociclib | Approved | Pharma | Inhibition, Target, Inhibitor | 127 | ||
| Tamoxifen | Approved | Pharma | Antagonist | TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens | 390 | |
| Ribociclib | Approved | Pharma | Target, antagonist, inhibitor | 0 | ||
| Anastrozole | Approved, Investigational | Pharma | Aromatase inhibitor, Aromatase Inhibitors, Hormone therapy, Potent aromatase (CYP19) inhibitor | 279 | ||
| Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1318 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| PD 0332991 isethionate |
|
827022-33-3 |
|
|
(5) Tocris Compounds for CDK6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BMS 265246 | Potent cdk1/2 inhibitor | 582315-72-8 |
| Kenpaullone | Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 | 142273-20-9 |
| PD 0332991 isethionate | Potent, selective Cdk4/6 inhibitor; brain penetrant | 827022-33-3 |
| Ro 3306 | Cyclin-dependent kinase (cdk) 1 inhibitor | 872573-93-8 |
| Senexin A | Cyclin-dependent kinase 8 (cdk8) inhibitor |
(12) ApexBio Compounds for CDK6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AT7519 | Multi-CDK inhibitor | 844442-38-2 |
| BS-181 HCl | CDK7 inhibitor,highly selective | 1397219-81-6 |
| Flavopiridol hydrochloride | 131740-09-5 | |
| LDC000067 | 1073485-20-7 | |
| LEE011 | CDK4/6 inhibitor | 1211441-98-3 |
| LEE011 hydrochloride | CDK inhibitor | 1211443-80-9 |
| LEE011 succinate | CDK inhibitor | 1374639-75-4 |
| LEE011 succinate hydrate | CDK inhibitor | 1374639-79-8 |
| LY2835219 | CDK4/6 inhibitor,potent and selective | 1231930-82-7 |
| LY2835219 free base | CDK inhibitor | 1231929-97-7 |
| Palbociclib (PD0332991) Isethionate | CDK4/6 inhibitor,highly selective | 827022-33-3 |
| PD 0332991 (Palbociclib) HCl | CDK4/6 inhibitor,highly selective | 827022-32-2 |
Drug Products
- ApexBio compounds for CDK6
Transcripts for CDK6 Gene
mRNA/cDNA for CDK6 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDK6 Gene
- Cyclin-dependent kinase 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CDK6
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK6
- GenScript: Design CRISPR guide RNA sequences for CDK6
miRNA Products
- Search ViGene Biosciences for CDK6
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CDK6
- Browse OriGene Inhibitory RNA Products For CDK6
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CDK6
- VectorBuilder custom plasmid, inducible vectors for CDK6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CDK6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
-
Amnion (Extraembryonic Tissues)
This gene is overexpressed in Peripheral blood mononuclear cells (14.8) and Testis (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK6 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDK6 Gene:
CDK6SOURCE GeneReport for Unigene cluster for CDK6 Gene:
Hs.119882mRNA Expression by UniProt/SwissProt for CDK6 Gene:
Q00534-CDK6_HUMAN
Tissue specificity:
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.
Evidence on tissue expression from TISSUES for CDK6 Gene
- Nervous system(4.6)
- Bone marrow(2.9)
- Lung(2.5)
- Skin(2.3)
- Blood(2.2)
- Intestine(2)
- Liver(2)
- Pancreas(2)
- Stomach(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK6 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- chin
- cranial nerve
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
- ureter
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs and template standards for CDK6
-
OriGene qPCR primer pairs for CDK6
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDK6 Gene
Orthologs for CDK6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDK6 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDK6 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CDK6 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CDK6 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDK6 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cdk6 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cdk6 34 16 |
|
||
| E030030I06Rik 35 |
|
OneToOne | |||
| chicken (Gallus gallus) |
Aves | CDK6 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CDK6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk6 34 |
|
||
| Str.20309 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cdk6 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005817 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cdk4 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cdk-4 36 34 35 |
|
||
| F52B5.2 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC28 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for CDK6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDK6 Gene
(57) SIMAP similar genes for CDK6 Gene using alignment to 2 proteins:
- CDK4
- CDC2
- CDK1
- CDK3
- DKFZp686L20222
- CDK11B
- CDC2L1
- CDC2L2
- CDK11A
- CDK5
- CDK14
- CDK7
- CDK20
- CDK15
- CDK9
- CDK18
- CDK17
- CDK10
- PCTK3
- CDKL4
- CDKL1
- MAK
- CDK16
- PCTK1
- NLK
- DKFZp434M058
- CDKL5
- CDKL3
- CDK19
- MAPK4
- ICK
- CDK13
- CDK12
- MOK
- CDKL2
- MAPK6
- MAPK15
- DKFZp686O0215
- CDK8
- MAPK14
- CDK2
- MAPK11
- MAPK1
- GSK3B
- MAPK3
- MAPK10
- MAPK13
- GSK3A
- MAPK12
- DKFZp686M02159
- DKFZp686D0638
- STK36
- MAPK8
- MAPK7
- MAPK9
- CSNK2A3
- CSNK2A1
Variants for CDK6 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CDK6 Gene
- CDK6_HUMAN-Q00534
- Genetic variations in CDK6 may influence stature as a quantitative trait, contributing to the stature quantitative trait locus 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs606231255 | Pathogenic, Microcephaly 12, primary, autosomal recessive (MCPH12) [MIM:616080] | 92,671,484(-) | GCTAC(A/G)CCACC | reference, missense | |
| VAR_041979 | A metastatic melanoma sample | ||||
| rs140409009 | Likely benign | 92,615,172(+) | CTGGC(A/C/T)GGGCG | reference, missense | |
| rs10 | -- | 92,754,574(+) | TCAGA(A/C)TTTCA | intron-variant | |
| rs1000035786 | -- | 92,828,536(+) | TTCCT(C/T)CTTAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2762687 | CNV | loss | 21179565 |
| esv3576407 | CNV | gain | 25503493 |
| esv3614146 | CNV | loss | 21293372 |
| esv3614148 | CNV | gain | 21293372 |
| esv3614149 | CNV | loss | 21293372 |
| nsv1074529 | CNV | deletion | 25765185 |
| nsv1133666 | CNV | deletion | 24896259 |
| nsv473626 | CNV | novel sequence insertion | 20440878 |
| nsv516592 | CNV | gain+loss | 19592680 |
| nsv819408 | CNV | gain | 19587683 |
| nsv831062 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.98% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CDK6 Gene
Disorders for CDK6 Gene
(23) MalaCards diseases for CDK6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microcephaly 12, primary, autosomal recessive |
|
|
| autosomal recessive primary microcephaly |
|
|
| endometrial squamous cell carcinoma |
|
|
| glioma |
|
|
| t-cell leukemia |
|
Search CDK6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CDK6_HUMAN- Microcephaly 12, primary, autosomal recessive (MCPH12) [MIM:616080]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO:0000269 PubMed:23918663}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CDK6
No data available for Genatlas for CDK6 Gene
Publications for CDK6 Gene
- CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a- independent mechanisms. (PMID: 17420273) Ruas M. … Peters G. (Mol. Cell. Biol. 2007) 3 4 22 64
- Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PMID: 17431401) Fujimoto T. … Nerlov C. (EMBO J. 2007) 3 4 22 64
- Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. (PMID: 14985467) Lucas J.J. … Gelfand E.W. (Mol. Cancer Res. 2004) 3 4 22 64
- Structural basis for CDK6 activation by a virus-encoded cyclin. (PMID: 11828325) Schulze-Gahmen U. … Kim S.-H. (Nat. Struct. Biol. 2002) 3 4 22 64
- Identification of G1 kinase activity for cdk6, a novel cyclin D partner. (PMID: 8114739) Meyerson M. … Harlow E. (Mol. Cell. Biol. 1994) 3 4 22 64
Products for CDK6 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CDK6
- EMD Millipore Purified and/or Recombinant CDK6 Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CDK6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK6
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK6
- Origene Custom Protein Services for CDK6
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CDK6
- Browse OriGene Inhibitory RNA Products For CDK6
- OriGene qPCR primer pairs and template standards for CDK6
- OriGene qPCR primer pairs for CDK6
- OriGene CRISPR knockouts for CDK6
- OriGene ORF clones in human for CDK6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK6
- GenScript: Next-day shipping cDNA ORF clone for CDK6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CDK6
- GenScript Custom Assay Services for CDK6
- GenScript Custom overexpressing Cell Line Services for CDK6
- GenScript: Design CRISPR guide RNA sequences for CDK6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK6
- Cell Signaling Technology (CST) Antibodies for CDK6 (CDK6)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CDK6
- Novus Biologicals proteins and lysates for CDK6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CDK6
- Abcam proteins for CDK6
- Search for Assays for CDK6 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for CDK6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CDK6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CDK6
- Addgene plasmids for CDK6
- antibodies-online Antibodies for CDK6: See all 253
- antibodies-online Kits for CDK6: See all 9
- antibodies-online Proteins for CDK6: See all 15
- Search antibodies-online for peptides
- GeneTex CDK6 antibody for CDK6
- Search GeneTex for Proteins for CDK6
- ViGene Biosciences adenoviral particle packaged cDNA for CDK6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDK6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDK6 gene
- Search ViGene Biosciences for CDK6
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK6
- Search Santa Cruz Biotechnology (SCBT) for CDK6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK6
- Search for CDK6 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CDK6
- Horizon Cell Lines for CDK6
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK6
- VectorBuilder custom plasmid, inducible vectors for CDK6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CDK6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer