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CDK6 Gene

protein-coding   GIFtS: 72
GCID: GC07M092234

Cyclin-Dependent Kinase 6

  See CDK6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 61 2     PLSTIRE2 5
Cell Division Protein Kinase 62 3     CDKN63
Serine/Threonine-Protein Kinase PLSTIRE2 3     EC 2.7.118
EC 2.7.11.223 8     

External Ids:    HGNC: 17771   Entrez Gene: 10212   Ensembl: ENSG000001058107   OMIM: 6033685   UniProtKB: Q005343   

Export aliases for CDK6 gene to outside databases

Previous GC identifers: GC07M090779 GC07M091841 GC07M091855 GC07M091878 GC07M092072 GC07M086843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK6 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of
the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The
activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including
D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to
phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is
up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have
been identified. (provided by RefSeq, Nov 2009)

GeneCards Summary for CDK6 Gene:
CDK6 (cyclin-dependent kinase 6) is a protein-coding gene. Diseases associated with CDK6 include primary autosomal recessive microcephaly type 12, and primary autosomal recessive microcephaly type 1. GO annotations related to this gene include cyclin binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK3.

UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes
G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to
form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of
cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell
differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic
cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone
of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons,
probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression,
changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell
differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription
transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes
the proliferation of beta-cells in pancreatic islets of Langerhans

summary for CDK6 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK6 (Cyclin-dependent kinase 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK6 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CDK6 promoter sequence
   Search Chromatin IP Primers for CDK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21-q22

CDK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092234:  view genomic region     (about GC identifiers)

Start:
92,234,235 bp from pter      End:
92,465,941 bp from pter
Size:
231,707 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 91,563,451-91,795,159     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 6  
Size: 326 amino acids; 36938 Da
Subunit: Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at
Thr-177 (By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with
Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma
herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates
NPM1 and thus lead to viral reactivation by reducing viral LANA levels
Miscellaneous: Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors,
lymphoma and melanoma) as a consequence of nearby translocations
Miscellaneous: Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients
Selected PDB 3D structures from and Proteopedia for CDK6 (see all 12):
1BI7 (3D)        1BI8 (3D)        1BLX (3D)        1G3N (3D)        1JOW (3D)        1XO2 (3D)    

Explore the universe of human proteins at neXtProt for CDK6: NX_Q00534

Explore proteomics data for CDK6 at MOPED

Post-translational modifications: 

  • Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity1
  • Ubiquitination2 at Lys26, Lys29, Lys43, Lys147, Lys160, Lys230, Lys257, Lys264, Lys274, Lys279,
                                 Lys287, Lys307
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK6 (Q00534) (see all 11)
     HPNVVRL  LADFGLA  VVHRDLK  RTDRETK 


    See CDK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138778.1  NP_001250.1  

    ENSEMBL proteins: 
     ENSP00000265734   ENSP00000397087  
    Reactome Protein details: Q00534

    CDK6 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK6 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDK6
    OriGene Protein Over-expression Lysate for CDK6
    OriGene MassSpec for CDK6
    OriGene Custom Protein Services for CDK6
    GenScript Custom Purified and Recombinant Proteins Services for CDK6
    Novus Biologicals CDK6 Proteins
    Novus Biologicals CDK6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK6

     
    Search eBioscience for Proteins for CDK6 

    CDK6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK6
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDK6 
    OriGene Antibodies for CDK6
    OriGene Custom Antibody Services for CDK6
    Novus Biologicals CDK6 Antibodies
    Abcam antibodies for CDK6
    Cloud-Clone Corp. Antibodies for CDK6
    ThermoFisher Antibody for CDK6
    LSBio Antibodies in human, mouse, rat for CDK6

    CDK6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK6
    Cloud-Clone Corp. CLIAs for CDK6
    Search eBioscience for ELISAs for CDK6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 6
    CDK4 subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00534

    ProtoNet protein and cluster: Q00534

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK6_HUMAN, Q00534
    Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes
    G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to
    form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of
    cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell
    differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic
    cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone
    of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons,
    probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression,
    changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell
    differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription
    transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes
    the proliferation of beta-cells in pancreatic islets of Langerhans
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991,
    4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24
    dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly
    down-regulated prior to cell differentiation (e.g. erythroid and osteoblast)
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry

         Genatlas biochemistry entry for CDK6:
    cyclin dependent kinase 6,cdc2 related gene family,involved in cell cycle regulation (G1 to S
    transition),complexing with cyclin D (D1,D2,D3)

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IDA8114739
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15232106
    GO:0005524ATP binding IDA9751050
         
    Find genes that share ontologies with CDK6           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK6:
     Decreased mitotic index  Decreased substrate adherent c  Increased apoptosis  Increased circadian period len 
     Synthetic lethal/sick with VHL  Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdk6):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  immune system  liver/biliary system  mortality/aging  muscle 
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with CDK6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdk6tm1Bbd for CDK6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK6:
    hsa-mir-103a-3p (MIRT027234), hsa-mir-22-3p (MIRT030654), hsa-mir-30a-3p (MIRT001760), hsa-mir-124-3p (MIRT002642), hsa-mir-218-5p (MIRT007145), hsa-mir-203a (MIRT004723), hsa-mir-29c-3p (MIRT003200), hsa-mir-21-5p (MIRT002406), hsa-mir-424-5p (MIRT000938), hsa-mir-193b-3p (MIRT016513), hsa-mir-29a-3p (MIRT000682), hsa-mir-107 (MIRT001233), hsa-let-7a-5p (MIRT000415), hsa-mir-16-5p (MIRT000939), hsa-mir-26b-5p (MIRT006307), hsa-mir-185-5p (MIRT004700), hsa-let-7b-5p (MIRT002297), hsa-mir-1303 (MIRT035884), hsa-mir-195-5p (MIRT000224), hsa-mir-26a-5p (MIRT006306), mmu-mir-124-3p (MIRT001014), mmu-mir-137-3p (MIRT001015), hsa-mir-29b-3p (MIRT000684), hsa-mir-449b-5p (MIRT016139), hsa-mir-191-5p (MIRT006721), hsa-mir-615-3p (MIRT040000), hsa-mir-34b-3p (MIRT003579), hsa-mir-137 (MIRT002490), hsa-mir-449a (MIRT003187), hsa-mir-34b-5p (MIRT000762), hsa-mir-34a-5p (MIRT001012)

    Block miRNA regulation of human, mouse, rat CDK6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK6 (see all 166):
    hsa-miR-106a hsa-miR-342-3p hsa-miR-3921 hsa-miR-502-3p hsa-miR-298 hsa-miR-149 hsa-miR-3116 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDK6
    Predesigned siRNA for gene silencing in human, mouse, rat CDK6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK6

    Clone
    Products:
         
    OriGene clones in human, mouse for CDK6 (see all 10)
    OriGene ORF clones in mouse, rat for CDK6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK6 (NM_001259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK6
    Addgene plasmids for CDK6 

    Cell Line
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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK6_HUMAN, Q00534: Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of
    spreading fibroblasts. Kinase activity only in nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2
    mitochondrion2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0001726ruffle IDA10205165
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with CDK6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK6 About   (see all 32)  
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    2Glioma
    Glioma0.51
    Melanoma0.43
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    5E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35


    Find genes that share SuperPaths with CDK6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK6 (see all 8)
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    HGF Pathway
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics

    1 Cell Signaling Technology (CST) Pathway for CDK6
        Cell Cycle / Checkpoint Control

    4 GeneGo (Thomson Reuters) Pathways for CDK6
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Cell cycle (generic schema)

    Selected BioSystems Pathways for CDK6 (see all 11)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    miRNAs involved in DDR
    Signaling Pathways in Glioblastoma

    4 Reactome Pathways for CDK6
        Oxidative Stress Induced Senescence
    Senescence-Associated Secretory Phenotype (SASP)
    Oncogene Induced Senescence
    Cyclin D associated events in G1


    Selected Kegg Pathways  (Kegg details for CDK6) (see all 14):
        Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Hepatitis B
    Measles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK6: 
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK6 (Q005341, 2, 3 ENSP000002657344) via UniProtKB, MINT, STRING, and/or I2D (see all 232)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNX1Q011961, 2, 3, ENSP000003003054EBI-295663,EBI-925904 MINT-4791080 MINT-4791148 MINT-4791064 MINT-4791100 I2D: score=2 STRING: ENSP00000300305
    CDKN2AP427711, 2, 3, ENSP000003551534I2D: score=2 EBI-295663,EBI-375053 MINT-25084 I2D: score=4 STRING: ENSP00000355153
    CCND3P302811, 2, 3, ENSP000003620824EBI-295663,EBI-375013 MINT-50439 I2D: score=8 STRING: ENSP00000362082
    CDKN2CP427731, 3, ENSP000002626624EBI-295663,EBI-711290 I2D: score=5 STRING: ENSP00000262662
    ATXN1P542532, 3, ENSP000002447694MINT-2857450 I2D: score=3 STRING: ENSP00000244769
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS16294322
    GO:0000278mitotic cell cycle TAS--
    GO:0001954positive regulation of cell-matrix adhesion IDA10205165
    GO:0003323type B pancreatic cell development IDA--
    GO:0006468protein phosphorylation IDA8114739

    Find genes that share ontologies with CDK6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for CDK6 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Compounds for CDK6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for CDK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL-- --target--10592235
    3,7,3',4'-TETRAHYDROXYFLAVONE-- --target--10592235
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    Selected Novoseek inferred chemical compound relationships for CDK6 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indole-3-carbinol 77 41 11297539 (9), 9461564 (6), 12840223 (4), 10808405 (1) (see all 6)
    3,3'-diindolylmethane 62 1 15661811 (1)
    silicon phthalocyanine 59 1 10086343 (1)
    eb 1089 53.3 5 10639575 (3), 10640426 (1), 11836565 (1)
    fisetin 37.8 4 15689157 (2), 17387141 (2)
    silymarin 35.2 3 9581834 (1), 9563902 (1)
    roscovitine 34.3 2 18003885 (1), 15741232 (1)
    17-(allylamino)-17-demethoxygeldanamycin 34 2 16267832 (1), 17157164 (1)
    indole 33.8 3 9461564 (1), 10808405 (1)
    lovastatin 33.6 2 10652602 (2)



    Find genes that share compounds with CDK6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CDK6 gene (2 alternative transcripts): 
    NM_001145306.1  NM_001259.6  

    Unigene Cluster for CDK6:

    Cyclin-dependent kinase 6
    Hs.119882  [show with all ESTs]
    Unigene Representative Sequence: NM_001145306
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265734(uc011khw.2 uc010lez.3) ENST00000467166 ENST00000424848
    ENST00000473078 ENST00000491250
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDK6 (see all 166):
    hsa-miR-106a hsa-miR-342-3p hsa-miR-3921 hsa-miR-502-3p hsa-miR-298 hsa-miR-149 hsa-miR-3116 hsa-miR-92b
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    Addgene plasmids for CDK6 
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      QuantiTect SYBR Green Assays in human, mouse, rat CDK6
      QuantiFast Probe-based Assays in human, mouse, rat CDK6

    Additional mRNA sequence: 

    AB073601.1 AK000660.1 AK055922.1 AK172791.1 AK313491.1 BC012914.1 BC027989.1 BC052264.1 
    BC063591.1 BC065026.1 X66365.1 

    14 DOTS entries:

    DT.101972926  DT.452094  DT.99984557  DT.100794931  DT.95079372  DT.445352  DT.95130246  DT.95279996 
    DT.40229358  DT.40297680  DT.91689778  DT.92436499  DT.95280002  DT.97797884 

    Selected AceView cDNA sequences (see all 406):

    Z41608 BM718299 AI739093 BX098997 BU633878 BG939646 AW192700 BX507386 
    BU166531 AI982583 AV726767 BQ675692 AI332630 BM783431 AA860694 BX504929 
    BM972870 AI739094 AB073601 AA861615 AJ713167 AA512994 BX118428 BG166127 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAAAATT
    CDK6 Expression
    About this image


    CDK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    CDK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119882

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Tissue specificity: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic
    progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in
    differentiating cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK6: 
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk61 , 5 cyclin-dependent kinase 61, 5 89.98(n)1
    96.32(a)1
      5 (2.04 cM)5
    125711  NM_009873.21  NP_034003.11 
     33443125 
    chicken
    (Gallus gallus)
    Aves CDK61 cyclin-dependent kinase 6 83.64(n)
    91.1(a)
      420558  NM_001007892.2  NP_001007893.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK66
    cyclin-dependent kinase 6
    89(a)
    1 ↔ 1
    6(21330537-21446873)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203092 Transcribed sequence with strong similarity to protein more 87.29(n)    AL783887.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk61 cyclin-dependent kinase 6 74.2(n)
    87.04(a)
      100034507  NM_001144053.1  NP_001137525.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk41 , 3 cell proliferation protein
    serine/threonine kinase3
    Cyclin-dependent kinase 41
    46(a)3
    53.52(n)1
    46.71(a)1
      2 53C93
    368541  NM_166185.11  NP_725595.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-41 , 3 serine/threonine kinase (CDC2/CDKX
    subfamily)3
    cdk-41
    40(a)3
    51.01(n)1
    41.28(a)1
      X(13551275-13552978)3
    1814721  NM_077855.41  NP_510256.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    45(a)
    1 → many
    II(560078-560974) YBR160W


    ENSEMBL Gene Tree for CDK6 (if available)
    TreeFam Gene Tree for CDK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK6 gene
    CDK32  CDK22  CDK42  CDK12  
    Selected SIMAP similar genes for CDK6 using alignment to 2 protein entries:     CDK6_HUMAN (see all proteins) (see all similar genes):
    CDK4    CDC2    CDK1    CDK3    CDC2L1    CDK11B
    DKFZp686L20222    CDC2L2    CDK11A    CDK14    CDK5    CDK7
    CDK15    CDK20    CDK17    CDK18    CDK9    CDK10

    Find genes that share paralogs with CDK6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CDK6_HUMAN, Q00534: Genetic variations in CDK6 may influence stature as a quantitative trait, contributing to the
    stature quantitative trait locus 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly
    heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on
    quantitative traits


    Selected SNPs for CDK6 (see all 3529)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419794
    A metastatic melanoma sample4--see VAR_0419792 P L mis40--------
    rs1129916091,2
    C--86930822(+) GTCTCAAAA/-  
            
    AAAAA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs58858111,2
    C--92235951(+) TTTTTT/-ACTTT 2 -- ut31 trp32Minor allele frequency- -:0.00NA CSA 4
    rs716992911,2
    C--92254534(+) ACTAA-/ACACACA 2 -- int10--------
    rs1995221771,2
    C--92254846(+) AAAAA-/ACAAAA 2 -- int10--------
    rs354895111,2
    C--92257602(+) AAAAA-/ACCCGA 2 -- int10--------
    rs604562861,2
    C--92257696(+) AAGGC-/AACTCT 2 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs2014885521,2
    C--92263789(+) TTTTT-/TGGTAA 2 -- int10--------
    rs2010937731,2
    C--92281069(+) TTTTT-/TGACAT 2 -- int10--------
    rs112856261,2
    C,F--92340867(+) TTTTTT/-TTTTT 2 -- int1 trp32Minor allele frequency- -:0.50NA 4

    HapMap Linkage Disequilibrium report for CDK6 (92234235 - 92465941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDK6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv888736CNV Loss21882294
    nsv831062CNV Gain17160897
    nsv819408CNV Gain19587683
    nsv516592CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing CDK6:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CDK6
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603368    OMIM disorders: --

    6 diseases for CDK6:    
    About MalaCards
    primary autosomal recessive microcephaly type 12    primary autosomal recessive microcephaly type 1    gastroesophageal junction adenocarcinoma    familial melanoma
    primary autosomal recessive microcephalies and seckel syndrome spectrum disorders    glioblastoma multiforme

    1 disease from the University of Copenhagen DISEASES database for CDK6:
    Retinoblastoma

    Find genes that share disorders with CDK6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDK6 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 88.1 82 18305152 (2), 19145199 (2), 11804329 (2), 9488660 (2) (see all 69)
    cancer 57.4 11 9177281 (1), 10475236 (1), 11676482 (1), 18391952 (1) (see all 11)
    tumors 56.6 58 15723654 (3), 18497076 (3), 10475236 (2), 14985467 (2) (see all 44)
    leukemia t-cell 51.9 1 9422538 (1)
    multiple tumors 39.8 1 9698532 (1)
    lymphoma 38.1 9 10597225 (2), 9422538 (1), 10879740 (1), 20086245 (1) (see all 5)
    glioblastoma 37.1 6 19188159 (1), 8806696 (1), 10884881 (1)
    breast cancer 37 17 9461564 (3), 11297539 (2), 12840223 (1), 12834607 (1) (see all 9)
    melanoma 35.7 11 10777219 (3), 17909018 (2), 8668202 (1), 10721488 (1) (see all 7)
    t-all 34.7 2 19001083 (1)

    Genetic Association Database (GAD): CDK6
    Human Genome Epidemiology (HuGE) Navigator: CDK6 (34 documents)
    Tumor Gene Database (TGDB): CDK6

    Export disorders for CDK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK6 gene, integrated from 10 sources (see all 626):
    (articles sorted by number of sources associating them with CDK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    2. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PubMed id 17431401)1, 2, 9 Fujimoto T.... Nerlov C. (EMBO J. 2007)
    3. Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. (PubMed id 14985467)1, 2, 9 Lucas J.J.... Gelfand E.W. (Mol. Cancer Res. 2004)
    4. Structural basis for CDK6 activation by a virus-encoded cyclin. (PubMed id 11828325)1, 2, 9 Schulze-Gahmen U. and Kim S.-H. (Nat. Struct. Biol. 2002)
    5. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. (PubMed id 8114739)1, 2, 9 Meyerson M. and Harlow E. (Mol. Cell. Biol. 1994)
    6. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a- independent mechanisms. (PubMed id 17420273)1, 2, 9 Ruas M.... Peters G. (Mol. Cell. Biol. 2007)
    7. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (Carcinogenesis 2008)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (Clin. Cancer Res. 2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    10. Genome-wide association analysis identifies 20 loci that influence adult height. (PubMed id 18391952)1, 4, 9 Weedon M.N....Frayling T.M. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1021 HGNC: 1777 AceView: CDK6 Ensembl:ENSG00000105810 euGenes: HUgn1021
    ECgene: CDK6 Kegg: 1021 H-InvDB: CDK6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK6 gene:
    Search GeneIP for patents involving CDK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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