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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK6 Gene

protein-coding   GIFtS: 73
GCID: GC07M092234

Cyclin-Dependent Kinase 6

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 61 2     PLSTIRE2 5
Cell Division Protein Kinase 62 3     CDKN63
Serine/Threonine-Protein Kinase PLSTIRE2 3     EC 2.7.118
EC 2.7.11.223 8     

External Ids:    HGNC: 17771   Entrez Gene: 10212   Ensembl: ENSG000001058107   OMIM: 6033685   UniProtKB: Q005343   

Export aliases for CDK6 gene to outside databases

Previous GC identifers: GC07M090779 GC07M091841 GC07M091855 GC07M091878 GC07M092072 GC07M086843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK6 Gene:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family
members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of
the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The
activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including
D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to
phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is
up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have
been identified. (provided by RefSeq, Nov 2009)

GeneCards Summary for CDK6 Gene: 
CDK6 (cyclin-dependent kinase 6) is a protein-coding gene. Diseases associated with CDK6 include gastroesophageal junction adenocarcinoma, and familial melanoma, and among its related super-pathways are G1-S Phase Transition and Glioma. GO annotations related to this gene include cyclin binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes
G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to
form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of
cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell
differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic
cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone
of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons,
probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression,
changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell
differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription
transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes
the proliferation of beta-cells in pancreatic islets of Langerhans

summary for CDK6 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK6 (Cyclin-dependent kinase 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK6 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CDK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21-q22

CDK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092234:  view genomic region     (about GC identifiers)

Start:
92,234,235 bp from pter      End:
92,465,941 bp from pter
Size:
231,707 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 91,563,451-91,795,159     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 6  
Size: 326 amino acids; 36938 Da
Subunit: Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at
Thr-177 (By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with
Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma
herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates
NPM1 and thus lead to viral reactivation by reducing viral LANA levels
Subcellular location: Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of
spreading fibroblasts. Kinase activity only in nucleus
Miscellaneous: Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors,
lymphoma and melanoma) as a consequence of nearby translocations
Miscellaneous: Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients
6/12 PDB 3D structures from and Proteopedia for CDK6 (see all 12):
1BI7 (3D)        1BI8 (3D)        1BLX (3D)        1G3N (3D)        1JOW (3D)        1XO2 (3D)    

Explore the universe of human proteins at neXtProt for CDK6: NX_Q00534

Explore proteomics data for CDK6 at MOPED 

Post-translational modifications:

  • UniProtKB: Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00534

  • 4/11 DME Specific Peptides for CDK6 (Q00534) (see all 11)
     HPNVVRL  LADFGLA  VVHRDLK  RTDRETK 

    CDK6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138778.1  NP_001250.1  

    ENSEMBL proteins: 
     ENSP00000265734   ENSP00000397087  
    Reactome Protein details: Q00534
    Human Recombinant Protein Products for CDK6: 
    EMD Millipore Purified and/or Recombinant CDK6 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDK6
    OriGene Protein Over-expression Lysate for CDK6
    OriGene MassSpec for CDK6 
    OriGene Custom Protein Services for CDK6
    GenScript Custom Purified and Recombinant Proteins Services for CDK6
    Novus Biologicals CDK6 Proteins
    Novus Biologicals CDK6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK6 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0001726ruffle IDA10205165
    GO:0005634nucleus IDA14985467
    GO:0005737cytoplasm IDA14985467
    GO:0005829cytosol TAS--

    CDK6 for ontologies           About GeneDecksing



    CDK6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK6
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDK6 
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    GenScript Superior Antibodies for CDK6
    Novus Biologicals CDK6 Antibodies
    Abcam antibodies for CDK6
    Cloud-Clone Corp. Antibodies for CDK6 
    ThermoFisher Antibody for CDK6
    LSBio Antibodies in human, mouse, rat for CDK6 

    Assay Products for CDK6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK6 
    Cloud-Clone Corp. CLIAs for CDK6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 6 
    CDK4 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q00534

    ProtoNet protein and cluster: Q00534

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK6_HUMAN, Q00534
    Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes
    G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to
    form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of
    cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell
    differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic
    cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone
    of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons,
    probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression,
    changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell
    differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription
    transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes
    the proliferation of beta-cells in pancreatic islets of Langerhans
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991,
    4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24
    dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly
    down-regulated prior to cell differentiation (e.g. erythroid and osteoblast)
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry

         Genatlas biochemistry entry for CDK6:
    cyclin dependent kinase 6,cdc2 related gene family,involved in cell cycle regulation (G1 to S
    transition),complexing with cyclin D (D1,D2,D3)

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IDA8114739
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15232106
    GO:0005524ATP binding IDA9751050
         
    CDK6 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK6:
     Decreased mitotic index  Decreased substrate adherent c  Increased apoptosis  Increased circadian period len 
     Synthetic lethal/sick with VHL  Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdk6):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  immune system  liver/biliary system  mortality/aging  muscle 
     reproductive system  tumorigenesis 

    CDK6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk6tm1Bbd for CDK6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK6 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK6:
    hsa-mir-30a (MIRT001760), hsa-mir-124 (MIRT002642), hsa-mir-203 (MIRT004723), hsa-mir-29c (MIRT003200), hsa-mir-424 (MIRT000938), hsa-mir-29a (MIRT000682), hsa-mir-107 (MIRT001233), hsa-mir-16 (MIRT000939), hsa-mir-185 (MIRT004700), hsa-let-7b (MIRT002297), mmu-mir-124 (MIRT001014), mmu-mir-137 (MIRT001015), hsa-mir-29b (MIRT000684), hsa-mir-137 (MIRT002490), hsa-mir-34b (MIRT003579), hsa-mir-449a (MIRT003187), hsa-mir-34b (MIRT000762), hsa-mir-34a (MIRT001012)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK6
    8/166 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK6 (see all 166):
    hsa-miR-106a hsa-miR-342-3p hsa-miR-3921 hsa-miR-502-3p hsa-miR-298 hsa-miR-149 hsa-miR-3116 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK6
    Sirion Biotech Validated adenovirus to knockdown CDK6 in human, mouse 
                         Customized adenovirus for overexpression of CDK6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK6 (see all 12)
    OriGene ORF clones in mouse, rat for CDK6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK6 (NM_001259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK6
    Sirion Biotech Customized lentivirus for stable overexpression of CDK6 
                         Customized lentivirus expression plasmids for stable overexpression of CDK6 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CDK6
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK6 About   (see all 28)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    2Glioma
    Glioma0.51
    Melanoma0.43
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    5Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CDK6
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Cell cycle (generic schema)

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK6 (see all 8)
        G1-S Phase Transition
    Cyclins and Cell Cycle Regulation
    HGF Pathway
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics

    1 Cell Signaling Technology (CST) Pathway for CDK6
        Cell Cycle / Checkpoint Control

    4 GeneGo (Thomson Reuters) Pathways for CDK6
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Cell cycle (generic schema)

    5/10 BioSystems Pathways for CDK6 (see all 10)
        DNA damage response
    Cell cycle
    G1 to S cell cycle control
    miRNAs involved in DDR
    Signaling Pathways in Glioblastoma

    5        Reactome Pathways for CDK6
        G1 Phase
    Mitotic G1-G1/S phases
    Cell Cycle
    Cell Cycle, Mitotic
    Cyclin D associated events in G1


    5/14         Kegg Pathways  (Kegg details for CDK6) (see all 14):
        Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Hepatitis B
    Measles


    CDK6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for CDK6 (Q005341, 2, 3 ENSP000002657344) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AP427711, 2, 3, ENSP000003551534I2D: score=2 EBI-295663,EBI-375053 MINT-25084 I2D: score=4 STRING: ENSP00000355153
    CCND3P302811, 2, 3, ENSP000003620824EBI-295663,EBI-375013 MINT-50439 I2D: score=8 STRING: ENSP00000362082
    RUNX1Q011962, 3, ENSP000003003054MINT-4791080 MINT-4791148 MINT-4791064 MINT-4791100 I2D: score=2 STRING: ENSP00000300305
    CDKN2CP427731, 3, ENSP000002626624EBI-295663,EBI-711290 I2D: score=5 STRING: ENSP00000262662
    ATXN1P542532, 3, ENSP000002447694MINT-2857450 I2D: score=3 STRING: ENSP00000244769
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle IEP8114739
    GO:0000082G1/S transition of mitotic cell cycle TAS16294322
    GO:0000278mitotic cell cycle TAS--
    GO:0001954positive regulation of cell-matrix adhesion IDA10205165
    GO:0002244hematopoietic progenitor cell differentiation IEA--

    CDK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK6 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK6:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CDK6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for CDK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL-- --target--10592235
    3,7,3',4'-TETRAHYDROXYFLAVONE-- --target--10592235
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352

    10/45 Novoseek inferred chemical compound relationships for CDK6 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indole-3-carbinol 77 41 11297539 (9), 9461564 (6), 12840223 (4), 10808405 (1) (see all 6)
    3,3'-diindolylmethane 62 1 15661811 (1)
    silicon phthalocyanine 59 1 10086343 (1)
    eb 1089 53.3 5 10639575 (3), 10640426 (1), 11836565 (1)
    fisetin 37.8 4 15689157 (2), 17387141 (2)
    silymarin 35.2 3 9581834 (1), 9563902 (1)
    roscovitine 34.3 2 18003885 (1), 15741232 (1)
    17-(allylamino)-17-demethoxygeldanamycin 34 2 16267832 (1), 17157164 (1)
    indole 33.8 3 9461564 (1), 10808405 (1)
    lovastatin 33.6 2 10652602 (2)

    Search CenterWatch for drugs/clinical trials and news about CDK6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for CDK6 gene (2 alternative transcripts): 
    NM_001145306.1  NM_001259.6  

    Unigene Cluster for CDK6:

    Cyclin-dependent kinase 6
    Hs.119882  [show with all ESTs]
    Unigene Representative Sequence: NM_001145306
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265734(uc011khw.2 uc010lez.3) ENST00000467166 ENST00000424848
    ENST00000473078 ENST00000491250
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB073601.1 AK000660.1 AK055922.1 AK172791.1 AK313491.1 BC012914.1 BC027989.1 BC052264.1 
    BC063591.1 BC065026.1 X66365.1 

    14 DOTS entries:

    DT.101972926  DT.452094  DT.99984557  DT.100794931  DT.95079372  DT.445352  DT.95130246  DT.95279996 
    DT.40229358  DT.40297680  DT.91689778  DT.92436499  DT.95280002  DT.97797884 

    24/406 AceView cDNA sequences (see all 406):

    AI982583 CD610992 BC063591 AA861615 BX504929 Z41608 AI738486 Z42074 
    BX118428 BM757392 AI023175 BM542506 AA262986 BX507386 AI739093 BM753088 
    AK055922 BQ422816 BE221813 BM718299 BM783431 BX096513 AI193926 CA446858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK6 expression in normal human tissues (normalized intensities)      CDK6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAAAATT
    CDK6 Expression
    About this image


    CDK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Substantia Nigra   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             fetal cartilage   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End

    See CDK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK6

    SOURCE GeneReport for Unigene cluster: Hs.119882

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Tissue specificity: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic
    progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in
    differentiating cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK6 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk61 , 5 cyclin-dependent kinase 61, 5 89.98(n)1
    96.32(a)1
      5 (2.04 cM)5
    125711  NM_009873.21  NP_034003.11 
     33443125 
    chicken
    (Gallus gallus)
    Aves CDK61 cyclin-dependent kinase 6 83.44(n)
    91.1(a)
      420558  NM_001007892.1  NP_001007893.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK66
    cyclin-dependent kinase 6
    89(a)
    1 ↔ 1
    6(21330537-21446873)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203092 Transcribed sequence with strong similarity to protein more 87.29(n)    AL783887.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk61 cyclin-dependent kinase 6 74.5(n)
    87.69(a)
      100034507  NM_001144053.1  NP_001137525.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk41 , 3 cell proliferation protein
    serine/threonine kinase3
    Cyclin-dependent kinase 41
    46(a)3
    53.59(n)1
    46.87(a)1
      2 53C93
    368541  NM_166184.11  NP_725594.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-41 , 3 serine/threonine kinase (CDC2/CDKX
    subfamily)3
    Protein CDK-41
    40(a)3
    51.01(n)1
    41.28(a)1
      X(13551275-13552978)3
    1814721  NM_077855.41  NP_510256.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    44(a)
    1 → many
    II(560078-560974)


    ENSEMBL Gene Tree for CDK6 (if available)
    TreeFam Gene Tree for CDK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK6 gene
    CDK182  CDK52  CDK152  CDK12  CDK42  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/57 SIMAP similar genes for CDK6 using alignment to 2 protein entries:     CDK6_HUMAN (see all proteins) (see all similar genes):
    CDK4    CDC2    CDK1    CDK3    CDC2L1    CDK11B
    DKFZp686L20222    CDC2L2    CDK11A    CDK14    CDK5    CDK7
    CDK15    CDK20    CDK17    CDK18    CDK9    CDK10

    CDK6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CDK6_HUMAN, Q00534
    Polymorphism: Genetic variations in CDK6 may influence stature as a quantitative trait, contributing to the
    stature quantitative trait locus 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly
    heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on
    quantitative traits


    10/3529 SNPs in CDK6 are shown (see all 3529)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419794
    A metastatic melanoma sample4--see VAR_0419792 P L mis40--------
    rs1129916091,2
    C--86930822(+) GTCTCAAAA/-  
            
    AAAAA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs58858111,2
    C--92235951(+) TTTTTT/-ACTTT 2 -- ut31 trp32Minor allele frequency- -:0.00NA CSA 4
    rs716992911,2
    C--92254534(+) ACTAA-/ACACACA 2 -- int10--------
    rs1995221771,2
    C--92254846(+) AAAAA-/ACAAAA 2 -- int10--------
    rs354895111,2
    C--92257602(+) AAAAA-/ACCCGA 2 -- int10--------
    rs604562861,2
    C--92257696(+) AAGGC-/AACTCT 2 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs2014885521,2
    C--92263789(+) TTTTT-/TGGTAA 2 -- int10--------
    rs2010937731,2
    C--92281069(+) TTTTT-/TGACAT 2 -- int10--------
    rs112856261,2
    C,F--92340867(+) TTTTTT/-TTTTT 2 -- int1 trp32Minor allele frequency- -:0.50NA 4

    HapMap Linkage Disequilibrium report for CDK6 (92234235 - 92465941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDK6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv888736CNV Loss21882294
    nsv831062CNV Gain17160897
    nsv819408CNV Gain19587683
    nsv516592CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603368    OMIM disorders: --

    20/81 diseases for CDK6 (see all 81):    About MalaCards
    gastroesophageal junction adenocarcinoma    familial melanoma    myxofibrosarcoma    inverted papilloma
    chronic myelomonocytic leukemia    splenic marginal zone lymphoma    crohn's disease    endocervicitis
    parathyroid adenoma    lymphoblastic lymphoma    kaposi's sarcoma    glioblastoma
    peripheral t-cell lymphoma    melanoma    cutaneous malignant melanoma    retinoblastoma
    papilloma    wegener's granulomatosis    inclusion body myositis    thyroid cancer

    1 disease from the University of Copenhagen DISEASES database for CDK6:
    Retinoblastoma

    CDK6 for disorders           About GeneDecksing

    10/40 Novoseek inferred disease relationships for CDK6 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 88.1 82 18305152 (2), 19145199 (2), 11804329 (2), 9488660 (2) (see all 69)
    cancer 57.4 11 9177281 (1), 10475236 (1), 11676482 (1), 18391952 (1) (see all 11)
    tumors 56.6 58 15723654 (3), 18497076 (3), 10475236 (2), 14985467 (2) (see all 44)
    leukemia t-cell 51.9 1 9422538 (1)
    multiple tumors 39.8 1 9698532 (1)
    lymphoma 38.1 9 10597225 (2), 9422538 (1), 10879740 (1), 20086245 (1) (see all 5)
    glioblastoma 37.1 6 19188159 (1), 8806696 (1), 10884881 (1)
    breast cancer 37 17 9461564 (3), 11297539 (2), 12840223 (1), 12834607 (1) (see all 9)
    melanoma 35.7 11 10777219 (3), 17909018 (2), 8668202 (1), 10721488 (1) (see all 7)
    t-all 34.7 2 19001083 (1)

    Genetic Association Database (GAD): CDK6
    Human Genome Epidemiology (HuGE) Navigator: CDK6 (34 documents)
    Tumor Gene Database (TGDB): CDK6

    Export disorders for CDK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK6 gene, integrated from 9 sources (see all 617):
    (articles sorted by number of sources associating them with CDK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (1992)
    2. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PubMed id 17431401)1, 2, 9 Fujimoto T....Nerlov C. (2007)
    3. Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. (PubMed id 14985467)1, 2, 9 Lucas J.J....Gelfand E.W. (2004)
    4. Structural basis for CDK6 activation by a virus-encoded cyclin. (PubMed id 11828325)1, 2, 9 Schulze-Gahmen U. and Kim S.H. (2002)
    5. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. (PubMed id 8114739)1, 2, 9 Meyerson M. and Harlow E. (1994)
    6. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. (PubMed id 17420273)1, 2, 9 Ruas M....Peters G. (2007)
    7. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (2008)
    8. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (2008)
    9. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (2008)
    10. Genome-wide association analysis identifies 20 loci that influence adult height. (PubMed id 18391952)1, 4, 9 Weedon M.N....Frayling T.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1021 HGNC: 1777 AceView: CDK6 Ensembl:ENSG00000105810 euGenes: HUgn1021
    ECgene: CDK6 Kegg: 1021 H-InvDB: CDK6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK6 gene:
    Search GeneIP for patents involving CDK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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