Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDK5RAP3 Gene

Aliases for CDK5RAP3 Gene

  • CDK5 Regulatory Subunit Associated Protein 3 2 3
  • LXXLL/Leucine-Zipper-Containing ARF-Binding Protein 3 4
  • LXXLL/Leucine-Zipper-Containing ARFbinding Protein 2 3
  • Ischemic Heart CDK5 Activator-Binding Protein C53 2 3
  • IC53 3 4
  • LZAP 3 4
  • CDK5 Regulatory Subunit Associated Protein IC53-2 3
  • CDK5 Activator-Binding Protein C53 4
  • Protein HSF-27 4
  • OK/SW-Cl.114 3
  • HSF-27 3
  • MST016 3
  • PP1553 3
  • C53 3

External Ids for CDK5RAP3 Gene

Previous GeneCards Identifiers for CDK5RAP3 Gene

  • GC17P045754
  • GC17P048529
  • GC17P046390
  • GC17P046523
  • GC17P043403
  • GC17P046048
  • GC17P041417

Summaries for CDK5RAP3 Gene

Entrez Gene Summary for CDK5RAP3 Gene

  • This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for CDK5RAP3 Gene

CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and cyclin binding.

UniProtKB/Swiss-Prot for CDK5RAP3 Gene

  • Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

  • (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry

Gene Wiki entry for CDK5RAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5RAP3 Gene

Genomics for CDK5RAP3 Gene

Regulatory Elements for CDK5RAP3 Gene

Transcription factor binding sites by QIAGEN in the CDK5RAP3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK5RAP3 Gene

Chromosome:
17
Start:
47,967,810 bp from pter
End:
47,981,786 bp from pter
Size:
13,977 bases
Orientation:
Plus strand

Genomic View for CDK5RAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK5RAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5RAP3 Gene

Proteins for CDK5RAP3 Gene

  • Protein details for CDK5RAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JB5-CK5P3_HUMAN
    Recommended name:
    CDK5 regulatory subunit-associated protein 3
    Protein Accession:
    Q96JB5
    Secondary Accessions:
    • B7Z6N4
    • D3DTU1
    • D3DTU2
    • F5H3I5
    • Q53FA2
    • Q9H3F8
    • Q9H8G0
    • Q9HBR9

    Protein attributes for CDK5RAP3 Gene

    Size:
    506 amino acids
    Molecular mass:
    56921 Da
    Quaternary structure:
    • Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471). (Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry (PubMed:21971960).
    SequenceCaution:
    • Sequence=AAK69655.1; Type=Frameshift; Positions=410; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK5RAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK5RAP3 Gene

Proteomics data for CDK5RAP3 Gene at MOPED

Post-translational modifications for CDK5RAP3 Gene

Antibody Products

No data available for DME Specific Peptides for CDK5RAP3 Gene

Domains & Families for CDK5RAP3 Gene

Suggested Antigen Peptide Sequences for CDK5RAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JB5

UniProtKB/Swiss-Prot:

CK5P3_HUMAN :
  • Belongs to the CDK5RAP3 family.
Family:
  • Belongs to the CDK5RAP3 family.
genes like me logo Genes that share domains with CDK5RAP3: view

No data available for Gene Families for CDK5RAP3 Gene

Function for CDK5RAP3 Gene

Molecular function for CDK5RAP3 Gene

UniProtKB/Swiss-Prot Function:
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
UniProtKB/Swiss-Prot Function:
(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry

Gene Ontology (GO) - Molecular Function for CDK5RAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16173922
GO:0019901 protein kinase binding NAS 10721722
GO:0030332 cyclin binding IPI 15790566
GO:0044389 ubiquitin-like protein ligase binding IDA 20531390
GO:0051019 mitogen-activated protein kinase binding IPI 21283629
genes like me logo Genes that share ontologies with CDK5RAP3: view
genes like me logo Genes that share phenotypes with CDK5RAP3: view

Animal Model Products

CRISPR Products

miRNA for CDK5RAP3 Gene

miRTarBase miRNAs that target CDK5RAP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK5RAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK5RAP3 Gene

Localization for CDK5RAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5RAP3 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes and associates with microtubules. {ECO:0000269 PubMed:23478299}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK5RAP3 Gene COMPARTMENTS Subcellular localization image for CDK5RAP3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CDK5RAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16173922
GO:0005730 NOT nucleolus IDA 16173922
GO:0005737 cytoplasm IDA 15790566
GO:0005813 centrosome IDA 19223857
GO:0005874 colocalizes_with microtubule IDA 23478299
genes like me logo Genes that share ontologies with CDK5RAP3: view

Pathways & Interactions for CDK5RAP3 Gene

SuperPathways for CDK5RAP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK5RAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity ISS --
GO:0001933 negative regulation of protein phosphorylation IMP 17785205
GO:0007095 mitotic G2 DNA damage checkpoint IMP 15790566
GO:0007420 brain development NAS 10915792
GO:0008283 cell proliferation IDA 12054757
genes like me logo Genes that share ontologies with CDK5RAP3: view

No data available for Pathways by source and SIGNOR curated interactions for CDK5RAP3 Gene

Drugs & Compounds for CDK5RAP3 Gene

No Compound Related Data Available

Transcripts for CDK5RAP3 Gene

Unigene Clusters for CDK5RAP3 Gene

CDK5 regulatory subunit associated protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK5RAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - - -
SP15: - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - - - - -
SP19: - - - -
SP20:
SP21: - -
SP22:
SP23:
SP24:
SP25: -
SP26: -

ExUns: 9g ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for CDK5RAP3 Gene

GeneLoc Exon Structure for
CDK5RAP3
ECgene alternative splicing isoforms for
CDK5RAP3

Expression for CDK5RAP3 Gene

mRNA expression in normal human tissues for CDK5RAP3 Gene

Protein differential expression in normal tissues from HIPED for CDK5RAP3 Gene

This gene is overexpressed in Bone (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK5RAP3 Gene



SOURCE GeneReport for Unigene cluster for CDK5RAP3 Gene Hs.20157

mRNA Expression by UniProt/SwissProt for CDK5RAP3 Gene

Q96JB5-CK5P3_HUMAN
Tissue specificity: Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).
genes like me logo Genes that share expression patterns with CDK5RAP3: view

Protein tissue co-expression partners for CDK5RAP3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK5RAP3 Gene

Orthologs for CDK5RAP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK5RAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK5RAP3 35
  • 89.95 (n)
  • 90.48 (a)
CDK5RAP3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK5RAP3 35
  • 90.72 (n)
  • 93.04 (a)
CDK5RAP3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk5rap3 35
  • 87.49 (n)
  • 88.22 (a)
Cdk5rap3 16
Cdk5rap3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK5RAP3 35
  • 99.37 (n)
  • 99.62 (a)
CDK5RAP3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk5rap3 35
  • 87.89 (n)
  • 88.42 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK5RAP3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK5RAP3 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK5RAP3 35
  • 69.43 (n)
  • 64.43 (a)
CDK5RAP3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK5RAP3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5rap3 35
  • 61.35 (n)
  • 58.17 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
cdk5rap3 35
  • 63.46 (n)
  • 62.93 (a)
cdk5rap3 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009811 35
  • 53.17 (n)
  • 42.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30291 35
  • 49.45 (n)
  • 38.8 (a)
CG30291 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y113G7B.16 35
  • 50.25 (n)
  • 42.22 (a)
cdkr-3 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06830 35
  • 43.51 (n)
  • 33.73 (a)
rice
(Oryza sativa)
Liliopsida Os06g0320100 35
  • 45.27 (n)
  • 33.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5146 36
  • 44 (a)
OneToOne
Species with no ortholog for CDK5RAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5RAP3 Gene

ENSEMBL:
Gene Tree for CDK5RAP3 (if available)
TreeFam:
Gene Tree for CDK5RAP3 (if available)

Paralogs for CDK5RAP3 Gene

Pseudogenes.org Pseudogenes for CDK5RAP3 Gene

genes like me logo Genes that share paralogs with CDK5RAP3: view

No data available for Paralogs for CDK5RAP3 Gene

Variants for CDK5RAP3 Gene

Sequence variations from dbSNP and Humsavar for CDK5RAP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2737 -- 47,981,705(-) GCCTG(A/G)TAGAC utr-variant-3-prime, missense, reference
rs736387 -- 47,982,002(+) GCTAC(A/G)TGTGG downstream-variant-500B
rs886444 -- 47,974,545(+) GAGTG(A/G)GAAGA intron-variant, utr-variant-5-prime
rs1043474 -- 47,980,731(+) TGCTG(G/T)AGGAT reference, stop-gained
rs1043577 -- 47,981,621(+) AAGCC(A/C)CAGGA utr-variant-3-prime, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDK5RAP3 Gene

Variant ID Type Subtype PubMed ID
nsv908575 CNV Loss 21882294
nsv469808 CNV Complex 16826518

Variation tolerance for CDK5RAP3 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK5RAP3 Gene

HapMap Linkage Disequilibrium report
CDK5RAP3
Human Gene Mutation Database (HGMD)
CDK5RAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5RAP3 Gene

Disorders for CDK5RAP3 Gene

Relevant External Links for CDK5RAP3

Human Genome Epidemiology (HuGE) Navigator
CDK5RAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK5RAP3
genes like me logo Genes that share disorders with CDK5RAP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK5RAP3 Gene

Publications for CDK5RAP3 Gene

  1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PMID: 10721722) Ching Y.-P. … Wang J.H. (Gene 2000) 2 23 67
  2. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. (PMID: 19223857) Jiang H. … Li H. (Cell Res. 2009) 23 67
  3. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. (PMID: 19541669) Zhuo M.L. … Liang C.C. (Cardiovasc. Res. 2009) 23 67
  4. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. (PMID: 15790566) Jiang H. … Li H. (J. Biol. Chem. 2005) 23 67
  5. Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. (PMID: 12737517) Xie Y.H. … Gu J.R. (Cell Res. 2003) 23 67

Products for CDK5RAP3 Gene

Sources for CDK5RAP3 Gene

Back to Top

Content