Aliases for CDK5RAP3 Gene
- CDK5 Regulatory Subunit Associated Protein 3 2 3 5
- LXXLL/Leucine-Zipper-Containing ARF-Binding Protein 3 4
- LXXLL/Leucine-Zipper-Containing ARFbinding Protein 2 3
- Ischemic Heart CDK5 Activator-Binding Protein C53 2 3
- IC53 3 4
- LZAP 3 4
- CDK5 Regulatory Subunit Associated Protein IC53-2 3
- CDK5 Regulatory Subunit-Associated Protein 3 3
External Ids for CDK5RAP3 Gene
Previous GeneCards Identifiers for CDK5RAP3 Gene
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
GeneCards Summary for CDK5RAP3 Gene
CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin binding.
UniProtKB/Swiss-Prot for CDK5RAP3 Gene
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.