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CDK5RAP3 Gene

protein-coding   GIFtS: 56
GCID: GC17P046048

CDK5 Regulatory Subunit Associated Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CDK5 Regulatory Subunit Associated Protein 31 2     MST0162
Ischemic Heart CDK5 Activator-Binding Protein C531 2     OK/SW-cl.1142
LXXLL/Leucine-Zipper-Containing ARFbinding Protein1 2     PP15532
IC532 3     CDK5 Regulatory Subunit Associated Protein IC53-22
C532     CDK5 Regulatory Subunit-Associated Protein 32
HSF-272     CDK5 Activator-Binding Protein C533
LZAP2     Protein HSF-273

External Ids:    HGNC: 186731   Entrez Gene: 802792   Ensembl: ENSG000001084657   OMIM: 6082025   UniProtKB: Q96JB53   
ORGUL members:         

Export aliases for CDK5RAP3 gene to outside databases

Previous GC identifers: GC17P045754 GC17P048529 GC17P046390 GC17P046523 GC17P043403 GC17P041417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK5RAP3 Gene:
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional
regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this
gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants
that encode different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for CDK5RAP3 Gene:
CDK5RAP3 (CDK5 regulatory subunit associated protein 3) is a protein-coding gene. Diseases associated with CDK5RAP3 include lung adenocarcinoma, and malignant glioma. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: CK5P3_HUMAN, Q96JB5
Function: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via
its interaction with CDK5R1 (By similarity)

Gene Wiki entry for CDK5RAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK5RAP3 gene promoter:
         p53   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK5RAP3 promoter sequence
   Search Chromatin IP Primers for CDK5RAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5RAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.2

CDK5RAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5RAP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P046048:  view genomic region     (about GC identifiers)

Start:
46,045,176 bp from pter      End:
46,059,147 bp from pter
Size:
13,972 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CK5P3_HUMAN, Q96JB5 (See protein sequence)
Recommended Name: CDK5 regulatory subunit-associated protein 3  
Size: 506 amino acids; 56921 Da
Subunit: Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By
similarity). Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1
Sequence caution: Sequence=AAK69655.1; Type=Frameshift; Positions=410;
Secondary accessions: D3DTU1 D3DTU2 Q53FA2 Q9H3F8 Q9H8G0 Q9HBR9
Alternative splicing: 3 isoforms:  Q96JB5-1   Q96JB5-2   Q96JB5-3   (Due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK5RAP3: NX_Q96JB5

Explore proteomics data for CDK5RAP3 at MOPED

Post-translational modifications: 

  • Phosphorylated in vitro by CDK5 (By similarity)1
  • Ubiquitination2 at Lys135, Lys166
  • Modification sites at PhosphoSitePlus

  • See CDK5RAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265126.1  NP_001265127.1  NP_001265145.1  NP_001265146.1  NP_788276.1  

    ENSEMBL proteins: 
     ENSP00000464542   ENSP00000438886   ENSP00000344683   ENSP00000462012   ENSP00000462042  
     ENSP00000462886   ENSP00000464419   ENSP00000462328   ENSP00000463950   ENSP00000462431  
     ENSP00000463431   ENSP00000463878   ENSP00000463442   ENSP00000464286  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008491 DUF773

    Graphical View of Domain Structure for InterPro Entry Q96JB5

    ProtoNet protein and cluster: Q96JB5

    2 Blocks protein domains:
    IPB003016 2-oxo acid dehydrogenase
    IPB008491 Protein of unknown function DUF773


    UniProtKB/Swiss-Prot: CK5P3_HUMAN, Q96JB5
    Similarity: Belongs to the CDK5RAP3 family


    CDK5RAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CK5P3_HUMAN, Q96JB5
    Function: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via
    its interaction with CDK5R1 (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17785205
    GO:0019901protein kinase binding NAS10721722
         
    CDK5RAP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cdk5rap3 (no phenotypes)

    CDK5RAP3 for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    golgi apparatus2
    mitochondrion2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    CDK5RAP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK5RAP3
    Interactions:

        GeneGlobe Interaction Network for CDK5RAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK5RAP3 (Q96JB51, 2, 3 ENSP000003446834) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRMP1Q141942, 3MINT-65201 I2D: score=4 
    SRPRBQ9Y5M82, 3MINT-65202 I2D: score=3 
    RELAQ042061, 3, ENSP000003842734EBI-718818,EBI-73886 I2D: score=1 STRING: ENSP00000384273
    ARL1P406163, ENSP000002616364I2D: score=2 STRING: ENSP00000261636
    CDK5R1Q150783, ENSP000003184864I2D: score=2 STRING: ENSP00000318486
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ISS--
    GO:0007420brain development NAS10915792
    GO:0045664regulation of neuron differentiation NAS10721722
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0071569protein ufmylation IDA--

    CDK5RAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for CDK5RAP3 (CK5P3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK5RAP3 gene (7 alternative transcripts): 
    NM_001278197.1  NM_001278198.1  NM_001278216.1  NM_001278217.1  NM_176096.2  NM_025197.2  NM_176095.1  

    Unigene Cluster for CDK5RAP3:

    CDK5 regulatory subunit associated protein 3
    Hs.20157  [show with all ESTs]
    Unigene Representative Sequence: AF217982
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 37):
    ENST00000579632 ENST00000536708(uc010wlc.2) ENST00000579853 ENST00000577442
    ENST00000338399 ENST00000584991(uc002imr.3) ENST00000584525 ENST00000581708
    ENST00000579605 ENST00000584063(uc002imq.1 uc002ims.3) ENST00000581160
    ENST00000578733 ENST00000584592 ENST00000578018 ENST00000582275 ENST00000577664
    ENST00000578525 ENST00000579175
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    Additional mRNA sequence: 

    AB062433.1 AF110322.1 AF217982.2 AF343090.1 AK023722.1 AK223387.1 AK225274.1 AK300643.1 
    AK301739.1 BC009957.2 BC013407.2 BC072435.1 

    Selected DOTS entries (see all 40):

    DT.100832303  DT.447098  DT.100767709  DT.95371061  DT.95247079  DT.100771670  DT.95371058  DT.100832302 
    DT.95087813  DT.91767432  DT.99928096  DT.120976914  DT.102834118  DT.120976937  DT.100832295  DT.86993444 
    DT.100039002  DT.120976935  DT.100771309  DT.95371064  DT.100772079  DT.102834120  DT.100832311  DT.102834117 

    Selected AceView cDNA sequences (see all 635):

    AL548143 AU142457 AW591376 BI711295 CR615649 BU682573 BG030811 BE393217 
    BQ067388 BU616062 BX442109 BQ644017 BQ050085 AL555693 BM764482 BQ651567 
    BQ962354 AI921417 CK820567 AL550146 BM857203 BQ055264 BE280553 CR624059 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP3 (see all 26)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ·
    SP1:                                                              -     -                 -     -     -     -           -           -     -     -     -     -   
    SP2:                                                              -     -                 -     -     -     -           -           -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                              -     -                       -     -     -           -           -     -     -     -     -   
    SP5:                                                              -     -                       -     -     -           -           -     -     -     -     -   

    ExUns: 9g ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
    SP1:  -     -     -     -                                                     -                             -                                       
    SP2:  -     -     -     -                                         -           -                                                                     
    SP3:                                                                          -                             -                                       
    SP4:  -     -     -     -     -                                                                                                                     
    SP5:  -     -     -                                                                                                                                 


    ECgene alternative splicing isoforms for CDK5RAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK5RAP3 expression in normal human tissues (normalized intensities)      CDK5RAP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCTACAA
    CDK5RAP3 Expression
    About this image


    CDK5RAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CDK5RAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK5RAP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20157

    UniProtKB/Swiss-Prot: CK5P3_HUMAN, Q96JB5
    Tissue specificity: Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK5RAP3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk5rap31 , 5 CDK5 regulatory subunit associated protein 31, 5 87.49(n)1
    88.22(a)1
      11 (60.16 cM)5
    802801  NM_030248.11  NP_084524.11 
     969074265 
    chicken
    (Gallus gallus)
    Aves CDK5RAP31 CDK5 regulatory subunit associated protein 3 69.43(n)
    64.43(a)
      430350  NM_001031586.1  NP_001026757.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK5RAP36
    CDK5 regulatory subunit associated protein 3
    72(a)
    1 ↔ 1
    6(74795487-74815579)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdk5rap31 CDK5 regulatory subunit associated protein 3 61.35(n)
    58.17(a)
      496928  NM_001011442.1  NP_001011442.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG985760.12   -- 73.48(n)   80949  BG985760.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG302911 CG30291 49.45(n)
    38.8(a)
      246534  NM_166417.2  NP_726016.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y113G7B.161 CELE_Y113G7B.16 50.25(n)
    42.22(a)
      180327  NM_075509.4  NP_507910.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G068301 AT5G06830 43.51(n)
    33.73(a)
      830574  NM_120766.3  NP_196301.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g03201001 Os06g0320100 45.27(n)
    33.13(a)
      4340889  NM_001064045.1  NP_001057510.1 


    ENSEMBL Gene Tree for CDK5RAP3 (if available)
    TreeFam Gene Tree for CDK5RAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK5RAP3 gene

    CDK5RAP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CDK5RAP3
    PGOHUM00000263055 PGOHUM00000247504


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK5RAP3 (see all 347)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116581151,2
    H--47061313(+) AGAATC/TTAGGT 1 -- us2k10--------
    rs752642621,2
    C--47061323(+) TCTTCA/CTGCTG 1 -- us2k10--------
    rs1399950381,2
    --47061342(+) CACTAC/TGCATT 1 -- us2k10--------
    rs1179724901,2
    C,F--47061440(+) CGGGCG/ACGGTG 1 -- us2k11Minor allele frequency- A:0.27NA 120
    rs29058451,2
    C,F,A,H--47061572(+) TAGCCT/GGGCGT 1 -- us2k15Minor allele frequency- G:0.33NA WA CSA 12
    rs1880037731,2
    --47061576(+) CGGGCC/GTGGTG 1 -- us2k10--------
    rs713698261,2
    C,F--47061622(+) AGGCAA/GGAGAA 1 -- us2k13Minor allele frequency- G:0.33NA CSA 6
    rs25250821,2
    H--47061832(+) TCTCAG/AACTCT 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1906941141,2
    --47061848(+) AGCTTC/TAGCCA 1 -- us2k10--------
    rs25250831,2
    C,F,A,H--47062020(+) cctccC/Gcaaca 1 -- us2k1 trp38Minor allele frequency- G:0.36EA NS NA WA 608

    HapMap Linkage Disequilibrium report for CDK5RAP3 (46045176 - 46059147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDK5RAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908575CNV Loss21882294
    nsv469808CNV Complex16826518

    Human Gene Mutation Database (HGMD): CDK5RAP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK5RAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5RAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608202    OMIM disorders: --

    11 diseases for CDK5RAP3:    About MalaCards
    lung adenocarcinoma    malignant glioma    schizophrenia    hepatocellular carcinoma
    colorectal cancer    adenocarcinoma    endotheliitis    neuronitis
    malaria    prostate cancer    prostatitis


    CDK5RAP3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CDK5RAP3 (1 document)

    Export disorders for CDK5RAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK5RAP3 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CDK5RAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PubMed id 10721722)1, 2, 3, 9 Ching Y.-P.... Wang J.H. (Gene 2000)
    2. Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. (PubMed id 12737517)1, 2, 9 Xie Y.H....Gu J.R. (Cell Res. 2003)
    3. A novel LZAP-binding protein, NLBP, inhibits cell invasion. (PubMed id 20164180)1, 2 Kwon J.... Kim H. (J. Biol. Chem. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. (PubMed id 12054757)1, 2 Chen J....Hui R.T. (Biochem. Biophys. Res. Commun. 2002)
    7. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. (PubMed id 19541669)1, 9 Zhuo M.L....Liang C.C. (Cardiovasc. Res. 2009)
    8. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. (PubMed id 15790566)1, 9 Jiang H....Li H. (J. Biol. Chem. 2005)
    9. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. (PubMed id 19223857)1, 9 Jiang H....Li H. (Cell Res. 2009)
    10. Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. (PubMed id 23478299)1 Wu J....Li H. (Cell Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80279 HGNC: 18673 AceView: CDK5RAP3 Ensembl:ENSG00000108465 euGenes: HUgn80279
    ECgene: CDK5RAP3 H-InvDB: CDK5RAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK5RAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK5RAP3 gene:
    Search GeneIP for patents involving CDK5RAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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