Aliases for CDK5RAP3 Gene
Aliases for CDK5RAP3 Gene
- CDK5 Regulatory Subunit Associated Protein 3 2 3 5
- LXXLL/Leucine-Zipper-Containing ARF-Binding Protein 3 4
- LXXLL/Leucine-Zipper-Containing ARFbinding Protein 2 3
- Ischemic Heart CDK5 Activator-Binding Protein C53 2 3
- IC53 3 4
- LZAP 3 4
- CDK5 Regulatory Subunit Associated Protein IC53-2 3
- CDK5 Regulatory Subunit-Associated Protein 3 3
External Ids for CDK5RAP3 Gene
- HGNC: 18673
- Entrez Gene: 80279
- Ensembl: ENSG00000108465
- OMIM: 608202
- UniProtKB: Q96JB5
Previous GeneCards Identifiers for CDK5RAP3 Gene
- GC17P045754
- GC17P048529
- GC17P046390
- GC17P046523
- GC17P043403
- GC17P046048
- GC17P041417
Summaries for CDK5RAP3 Gene
-
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
GeneCards Summary for CDK5RAP3 Gene
CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and cyclin binding.
UniProtKB/Swiss-Prot for CDK5RAP3 Gene
-
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
-
(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5RAP3 Gene
Genomics for CDK5RAP3 Gene
Regulatory Elements for CDK5RAP3 Gene
Enhancers for CDK5RAP3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CDK5RAP3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CDK5RAP3 gene promoter:
Regulatory Element Products
Genomic Location for CDK5RAP3 Gene
- Chromosome:
- 17
- Start:
- 47,967,810 bp from pter
- End:
- 47,981,786 bp from pter
- Size:
- 13,977 bases
- Orientation:
- Plus strand
Genomic View for CDK5RAP3 Gene
Genes around CDK5RAP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
CDK5RAP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK5RAP3 Gene
Proteins for CDK5RAP3 Gene
-
Protein details for CDK5RAP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96JB5-CK5P3_HUMAN
- Recommended name:
- CDK5 regulatory subunit-associated protein 3
- Protein Accession:
- Q96JB5
- B7Z6N4
- D3DTU1
- D3DTU2
- F5H3I5
- Q53FA2
- Q9H3F8
- Q9H8G0
- Q9HBR9
Protein attributes for CDK5RAP3 Gene
- Size:
- 506 amino acids
- Molecular mass:
- 56921 Da
- Quaternary structure:
-
- Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471).
- (Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry.
- SequenceCaution:
-
- Sequence=AAK69655.1; Type=Frameshift; Positions=410; Evidence={ECO:0000305};
Protein Expression for CDK5RAP3 Gene
Post-translational modifications for CDK5RAP3 Gene
- Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope.
- May be phosphorylated by CDK5.
- May be ufmylated.
- Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1.
- Ubiquitination at posLast=135135 and Lys166
- Modification sites at PhosphoSitePlus
Other Protein References for CDK5RAP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CDK5RAP3
- Novus Biologicals Antibodies for CDK5RAP3
- Invitrogen Antibodies for CDK5RAP3
- antibodies-online Antibodies for CDK5RAP3: See all 45
- Search GeneTex for Antibodies for CDK5RAP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK5RAP3
Protein Products
-
OriGene Purified Proteins for CDK5RAP3
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK5RAP3
- Origene Custom Protein Services for CDK5RAP3
- ProSpec Recombinant Proteins for CDK5RAP3
- antibodies-online Proteins for CDK5RAP3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CDK5RAP3
Assay Products
No data available for DME Specific Peptides for CDK5RAP3 Gene
Domains & Families for CDK5RAP3 Gene
Protein Domains for CDK5RAP3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK5RAP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96JB5- Family:
-
- Belongs to the CDK5RAP3 family.
No data available for Gene Families for CDK5RAP3 Gene
Function for CDK5RAP3 Gene
Molecular function for CDK5RAP3 Gene
- UniProtKB/Swiss-Prot Function:
- Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16173922 |
| GO:0019901 | protein kinase binding | NAS | 10721722 |
| GO:0030332 | cyclin binding | IPI | 15790566 |
| GO:0044389 | ubiquitin-like protein ligase binding | IDA | 20531390 |
| GO:0051019 | mitogen-activated protein kinase binding | IPI | 21283629 |
Phenotypes for CDK5RAP3 Gene
- MGI mutant phenotypes for CDK5RAP3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CDK5RAP3:
Animal Models for CDK5RAP3 Gene
- MGI Knock Outs for CDK5RAP3:
-
- Cdk5rap3 tm1b(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK5RAP3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK5RAP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5RAP3 gene
- Search ViGene Biosciences for CDK5RAP3
CRISPR Products
-
OriGene CRISPR knockouts for CDK5RAP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK5RAP3
- GenScript: Design CRISPR guide RNA sequences for CDK5RAP3
miRNA for CDK5RAP3 Gene
- miRTarBase miRNAs that target CDK5RAP3
miRNA Products
- Search ViGene Biosciences for CDK5RAP3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CDK5RAP3
- Browse OriGene Inhibitory RNA Products For CDK5RAP3
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5RAP3 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK5RAP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDK5RAP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK5RAP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CDK5RAP3
-
ViGene Biosciences adenoviral particle packaged cDNA for CDK5RAP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK5RAP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5RAP3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK5RAP3 Gene
Localization for CDK5RAP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK5RAP3 Gene
- Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes and associates with microtubules. {ECO:0000269 PubMed:23478299}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 16173922 |
| GO:0005730 | NOT nucleolus | IDA | 16173922 |
| GO:0005737 | cytoplasm | IDA,IEA | 15790566 |
| GO:0005813 | centrosome | IDA | 19223857 |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for CDK5RAP3 Gene
No Data Available
Interacting Proteins for CDK5RAP3 Gene
Selected Interacting proteins:
ENSP00000344683
Q96JB5-CK5P3_HUMAN
for CDK5RAP3 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | ISS | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IMP | 17785205 |
| GO:0007095 | mitotic G2 DNA damage checkpoint | IMP | 15790566 |
| GO:0007420 | brain development | NAS | 10915792 |
| GO:0008283 | cell proliferation | IDA | 12054757 |
No data available for Pathways by source and SIGNOR curated interactions for CDK5RAP3 Gene
Transcripts for CDK5RAP3 Gene
mRNA/cDNA for CDK5RAP3 Gene
- (11) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (635) Selected AceView cDNA sequences:
- (37) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDK5RAP3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK5RAP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK5RAP3
- GenScript: Design CRISPR guide RNA sequences for CDK5RAP3
miRNA Products
- Search ViGene Biosciences for CDK5RAP3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CDK5RAP3
- Browse OriGene Inhibitory RNA Products For CDK5RAP3
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5RAP3 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK5RAP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CDK5RAP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK5RAP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | · | 2h | · | 2i | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f | · |
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| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
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| SP5: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
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| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
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| SP13: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
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| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP25: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP26: | - |
| ExUns: | 9g | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | · | 19c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
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| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
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| SP20: | - | ||||||||||||||||||||||||||||||||||||||||||||||
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| SP22: | |||||||||||||||||||||||||||||||||||||||||||||||
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| SP26: |
Expression for CDK5RAP3 Gene
This gene is overexpressed in Bone (27.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK5RAP3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CDK5RAP3 Gene:
CDK5RAP3SOURCE GeneReport for Unigene cluster for CDK5RAP3 Gene:
Hs.20157mRNA Expression by UniProt/SwissProt for CDK5RAP3 Gene:
Q96JB5-CK5P3_HUMAN
Tissue specificity:
Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).
Evidence on tissue expression from TISSUES for CDK5RAP3 Gene
- Nervous system(5)
- Intestine(4.6)
- Liver(4.6)
- Kidney(4.4)
- Eye(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CDK5RAP3
-
OriGene qPCR primer pairs for CDK5RAP3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK5RAP3 Gene
Orthologs for CDK5RAP3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDK5RAP3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CDK5RAP3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CDK5RAP3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cdk5rap3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cdk5rap3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDK5RAP3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDK5RAP3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CDK5RAP3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CDK5RAP3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk5rap3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cdk5rap3 34 35 |
|
||
| -- 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009811 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG30291 35 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y113G7B.16 34 |
|
||
| cdkr-3 35 |
|
OneToOne | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G06830 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0320100 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5146 35 |
|
OneToOne |
- Species where no ortholog for CDK5RAP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDK5RAP3 Gene
Pseudogenes.org Pseudogenes for CDK5RAP3 Gene
No data available for Paralogs for CDK5RAP3 Gene
Variants for CDK5RAP3 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000356865 | -- | 47,977,250(+) | TTCAC(A/G)CCATT | intron-variant | |
| rs1000358301 | -- | 47,978,731(+) | AGTGA(G/T)TCTGT | intron-variant | |
| rs1000642657 | -- | 47,971,753(+) | TCACC(C/T)GAGGT | intron-variant | |
| rs1000680018 | -- | 47,980,085(+) | AGGTC(C/T)GGGGT | intron-variant | |
| rs1000904795 | -- | 47,972,935(+) | TATGC(A/T)TGGCT | intron-variant |
Residual Variation Intolerance Score:
85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.90;
67.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CDK5RAP3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5RAP3 Gene
Disorders for CDK5RAP3 Gene
Relevant External Links for CDK5RAP3
No disorders were found for CDK5RAP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK5RAP3 Gene
Publications for CDK5RAP3 Gene
- Cloning of three novel neuronal Cdk5 activator binding proteins. (PMID: 10721722) Ching Y.-P. … Wang J.H. (Gene 2000) 2 3 4 22 64
- Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. (PMID: 19223857) Jiang H. … Li H. (Cell Res. 2009) 3 4 22 64
- Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. (PMID: 15790566) Jiang H. … Li H. (J. Biol. Chem. 2005) 3 4 22 64
- Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. (PMID: 12737517) Xie Y.H. … Gu J.R. (Cell Res. 2003) 3 4 22 64
- Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. (PMID: 23478299) Wu J. … Li H. (Cell Res. 2013) 3 4 64
Products for CDK5RAP3 Gene
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- OriGene Purified Proteins for CDK5RAP3
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK5RAP3
- Origene Custom Protein Services for CDK5RAP3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CDK5RAP3
- Browse OriGene Inhibitory RNA Products For CDK5RAP3
- OriGene qPCR primer pairs and template standards for CDK5RAP3
- OriGene qPCR primer pairs for CDK5RAP3
- OriGene CRISPR knockouts for CDK5RAP3
- OriGene ORF clones in human for CDK5RAP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK5RAP3
- GenScript: Next-day shipping cDNA ORF clone for CDK5RAP3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CDK5RAP3
- GenScript Custom Assay Services for CDK5RAP3
- GenScript Custom overexpressing Cell Line Services for CDK5RAP3
- GenScript: Design CRISPR guide RNA sequences for CDK5RAP3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK5RAP3
- Sino Biological Human cDNA Clone for CDK5RAP3
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CDK5RAP3
- Novus Biologicals proteins and lysates for CDK5RAP3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CDK5RAP3
- antibodies-online Antibodies for CDK5RAP3: See all 45
- Search antibodies-online for kits
- antibodies-online Proteins for CDK5RAP3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CDK5RAP3
- Search GeneTex for Proteins for CDK5RAP3
- ViGene Biosciences adenoviral particle packaged cDNA for CDK5RAP3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDK5RAP3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDK5RAP3 gene
- Search ViGene Biosciences for CDK5RAP3
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK5RAP3
- Search Santa Cruz Biotechnology (SCBT) for CDK5RAP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK5RAP3
- Horizon Cell Lines for CDK5RAP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK5RAP3
- VectorBuilder custom plasmid, inducible vectors for CDK5RAP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK5RAP3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CDK5RAP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (26) UniGene
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- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer