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Aliases for CDK5RAP3 Gene

Aliases for CDK5RAP3 Gene

  • CDK5 Regulatory Subunit Associated Protein 3 2 3
  • LXXLL/Leucine-Zipper-Containing ARF-Binding Protein 3 4
  • LXXLL/Leucine-Zipper-Containing ARFbinding Protein 2 3
  • Ischemic Heart CDK5 Activator-Binding Protein C53 2 3
  • IC53 3 4
  • LZAP 3 4
  • CDK5 Regulatory Subunit Associated Protein IC53-2 3
  • CDK5 Regulatory Subunit-Associated Protein 3 3
  • CDK5 Activator-Binding Protein C53 4
  • Protein HSF-27 4
  • OK/SW-Cl.114 3
  • HSF-27 3
  • MST016 3
  • PP1553 3
  • C53 3

External Ids for CDK5RAP3 Gene

Previous GeneCards Identifiers for CDK5RAP3 Gene

  • GC17P045754
  • GC17P048529
  • GC17P046390
  • GC17P046523
  • GC17P043403
  • GC17P046048
  • GC17P041417

Summaries for CDK5RAP3 Gene

Entrez Gene Summary for CDK5RAP3 Gene

  • This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for CDK5RAP3 Gene

CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for CDK5RAP3 Gene

  • Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity).

Gene Wiki entry for CDK5RAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5RAP3 Gene

Genomics for CDK5RAP3 Gene

Regulatory Elements for CDK5RAP3 Gene

Transcription factor binding sites by QIAGEN in the CDK5RAP3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK5RAP3 Gene

Start:
47,967,810 bp from pter
End:
47,981,786 bp from pter
Size:
13,977 bases
Orientation:
Plus strand

Genomic View for CDK5RAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK5RAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5RAP3 Gene

Proteins for CDK5RAP3 Gene

  • Protein details for CDK5RAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JB5-CK5P3_HUMAN
    Recommended name:
    CDK5 regulatory subunit-associated protein 3
    Protein Accession:
    Q96JB5
    Secondary Accessions:
    • B7Z6N4
    • D3DTU1
    • D3DTU2
    • F5H3I5
    • Q53FA2
    • Q9H3F8
    • Q9H8G0
    • Q9HBR9

    Protein attributes for CDK5RAP3 Gene

    Size:
    506 amino acids
    Molecular mass:
    56921 Da
    Quaternary structure:
    • Interacts with CDK5R1. CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interacts with DDRGK1 (PubMed:20228063).
    SequenceCaution:
    • Sequence=AAK69655.1; Type=Frameshift; Positions=410; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK5RAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK5RAP3 Gene

Proteomics data for CDK5RAP3 Gene at MOPED

Post-translational modifications for CDK5RAP3 Gene

Antibody Products

No data available for DME Specific Peptides for CDK5RAP3 Gene

Domains for CDK5RAP3 Gene

Suggested Antigen Peptide Sequences for CDK5RAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JB5

UniProtKB/Swiss-Prot:

CK5P3_HUMAN :
  • Q96JB5
Family:
  • Belongs to the CDK5RAP3 family.
genes like me logo Genes that share domains with CDK5RAP3: view

No data available for Gene Families for CDK5RAP3 Gene

Function for CDK5RAP3 Gene

Molecular function for CDK5RAP3 Gene

UniProtKB/Swiss-Prot Function: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity).

Gene Ontology (GO) - Molecular Function for CDK5RAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16173922
GO:0019901 protein kinase binding NAS 10721722
GO:0030332 cyclin binding IPI 15790566
GO:0044389 ubiquitin-like protein ligase binding IDA 20531390
GO:0051059 NF-kappaB binding IPI 17785205
genes like me logo Genes that share ontologies with CDK5RAP3: view

Animal Model Products

CRISPR Products

miRNA for CDK5RAP3 Gene

miRTarBase miRNAs that target CDK5RAP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK5RAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK5RAP3 Gene

Localization for CDK5RAP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK5RAP3 Gene COMPARTMENTS Subcellular localization image for CDK5RAP3 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CDK5RAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16173922
GO:0005730 NOT nucleolus IDA 16173922
GO:0005737 cytoplasm IDA 15790566
GO:0005813 centrosome IDA 19223857
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with CDK5RAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK5RAP3 Gene

Pathways for CDK5RAP3 Gene

SuperPathways for CDK5RAP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK5RAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity ISS --
GO:0001933 negative regulation of protein phosphorylation IMP 17785205
GO:0007095 mitotic G2 DNA damage checkpoint IMP 15790566
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0007420 brain development NAS 10915792
genes like me logo Genes that share ontologies with CDK5RAP3: view

No data available for Pathways by source for CDK5RAP3 Gene

Transcripts for CDK5RAP3 Gene

Unigene Clusters for CDK5RAP3 Gene

CDK5 regulatory subunit associated protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK5RAP3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - - -
SP15: - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - - - - -
SP19: - - - -
SP20:
SP21: - -
SP22:
SP23:
SP24:
SP25: -
SP26: -

ExUns: 9g ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for CDK5RAP3 Gene

GeneLoc Exon Structure for
CDK5RAP3
ECgene alternative splicing isoforms for
CDK5RAP3

Expression for CDK5RAP3 Gene

mRNA expression in normal human tissues for CDK5RAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK5RAP3 Gene

SOURCE GeneReport for Unigene cluster for CDK5RAP3 Gene Hs.20157

mRNA Expression by UniProt/SwissProt for CDK5RAP3 Gene

Q96JB5-CK5P3_HUMAN
Tissue specificity: Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.
genes like me logo Genes that share expressions with CDK5RAP3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDK5RAP3 Gene

Orthologs for CDK5RAP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK5RAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK5RAP3 35
  • 99.37 (n)
  • 99.62 (a)
CDK5RAP3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK5RAP3 35
  • 89.95 (n)
  • 90.48 (a)
CDK5RAP3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK5RAP3 35
  • 90.72 (n)
  • 93.04 (a)
CDK5RAP3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk5rap3 35
  • 87.49 (n)
  • 88.22 (a)
Cdk5rap3 16
Cdk5rap3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK5RAP3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK5RAP3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk5rap3 35
  • 87.89 (n)
  • 88.42 (a)
chicken
(Gallus gallus)
Aves CDK5RAP3 35
  • 69.43 (n)
  • 64.43 (a)
CDK5RAP3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK5RAP3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5rap3 35
  • 61.35 (n)
  • 58.17 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
cdk5rap3 35
  • 63.46 (n)
  • 62.93 (a)
cdk5rap3 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009811 35
  • 53.17 (n)
  • 42.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30291 35
  • 49.45 (n)
  • 38.8 (a)
CG30291 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cdkr-3 36
  • 39 (a)
OneToOne
CELE_Y113G7B.16 35
  • 50.25 (n)
  • 42.22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06830 35
  • 43.51 (n)
  • 33.73 (a)
rice
(Oryza sativa)
Liliopsida Os06g0320100 35
  • 45.27 (n)
  • 33.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5146 36
  • 44 (a)
OneToOne
Species with no ortholog for CDK5RAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5RAP3 Gene

ENSEMBL:
Gene Tree for CDK5RAP3 (if available)
TreeFam:
Gene Tree for CDK5RAP3 (if available)

Paralogs for CDK5RAP3 Gene

Pseudogenes.org Pseudogenes for CDK5RAP3 Gene

genes like me logo Genes that share paralogs with CDK5RAP3: view

No data available for Paralogs for CDK5RAP3 Gene

Variants for CDK5RAP3 Gene

Sequence variations from dbSNP and Humsavar for CDK5RAP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2737 -- 47,981,705(-) GCCTG(A/G)TAGAC utr-variant-3-prime, missense, reference
rs736387 -- 47,982,002(+) GCTAC(A/G)TGTGG downstream-variant-500B
rs886444 -- 47,974,545(+) GAGTG(A/G)GAAGA intron-variant, utr-variant-5-prime
rs1043474 -- 47,980,731(+) TGCTG(G/T)AGGAT reference, stop-gained
rs1043577 -- 47,981,621(+) AAGCC(A/C)CAGGA utr-variant-3-prime, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDK5RAP3 Gene

Variant ID Type Subtype PubMed ID
nsv908575 CNV Loss 21882294
nsv469808 CNV Complex 16826518

Relevant External Links for CDK5RAP3 Gene

HapMap Linkage Disequilibrium report
CDK5RAP3
Human Gene Mutation Database (HGMD)
CDK5RAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5RAP3 Gene

Disorders for CDK5RAP3 Gene

Relevant External Links for CDK5RAP3

Human Genome Epidemiology (HuGE) Navigator
CDK5RAP3
genes like me logo Genes that share disorders with CDK5RAP3: view

No data available for UniProtKB/Swiss-Prot for CDK5RAP3 Gene

Publications for CDK5RAP3 Gene

  1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PMID: 10721722) Ching Y.-P. … Wang J.H. (Gene 2000) 2 3 4 23
  2. Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. (PMID: 12737517) Xie Y.H. … Gu J.R. (Cell Res. 2003) 3 4 23
  3. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. (PMID: 15790566) Jiang H. … Li H. (J. Biol. Chem. 2005) 3 23
  4. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. (PMID: 19223857) Jiang H. … Li H. (Cell Res. 2009) 3 23
  5. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. (PMID: 19541669) Zhuo M.L. … Liang C.C. (Cardiovasc. Res. 2009) 3 23

Products for CDK5RAP3 Gene

Sources for CDK5RAP3 Gene

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