Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDK5RAP1 Gene

Aliases for CDK5RAP1 Gene

  • CDK5 Regulatory Subunit Associated Protein 1 2 3
  • CDK5 Activator-Binding Protein C42 3 4
  • C20orf34 3 4
  • CDK5 Regulatory Subunit-Associated Protein 1 3
  • Chromosome 20 Open Reading Frame 34 2
  • HSPC167 3
  • CGI-05 3
  • C42 3

External Ids for CDK5RAP1 Gene

Previous HGNC Symbols for CDK5RAP1 Gene

  • C20orf34

Previous GeneCards Identifiers for CDK5RAP1 Gene

  • GC20M031705
  • GC20M032615
  • GC20M032662
  • GC20M031410
  • GC20M031946
  • GC20M028734

Summaries for CDK5RAP1 Gene

Entrez Gene Summary for CDK5RAP1 Gene

  • This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for CDK5RAP1 Gene

CDK5RAP1 (CDK5 Regulatory Subunit Associated Protein 1) is a Protein Coding gene. Diseases associated with CDK5RAP1 include mikulicz disease. GO annotations related to this gene include protein kinase binding and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is CDKAL1.

UniProtKB/Swiss-Prot for CDK5RAP1 Gene

  • Specifically inhibits CDK5 activation by CDK5R1

Gene Wiki entry for CDK5RAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5RAP1 Gene

Genomics for CDK5RAP1 Gene

Regulatory Elements for CDK5RAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK5RAP1 Gene

Start:
33,358,839 bp from pter
End:
33,401,569 bp from pter
Size:
42,731 bases
Orientation:
Minus strand

Genomic View for CDK5RAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK5RAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5RAP1 Gene

Proteins for CDK5RAP1 Gene

  • Protein details for CDK5RAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ6-CK5P1_HUMAN
    Recommended name:
    CDK5 regulatory subunit-associated protein 1
    Protein Accession:
    Q96SZ6
    Secondary Accessions:
    • A8K7R0
    • Q5QP46
    • Q5QP47
    • Q5QP48
    • Q675N4
    • Q675N5
    • Q9BVG6
    • Q9BWZ5
    • Q9H859
    • Q9NZZ9
    • Q9Y3F0

    Protein attributes for CDK5RAP1 Gene

    Size:
    601 amino acids
    Molecular mass:
    67689 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
    Quaternary structure:
    • Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.
    SequenceCaution:
    • Sequence=AAD34147.1; Type=Frameshift; Positions=3, 32, 128, 133, 569; Evidence={ECO:0000305}; Sequence=AAF29131.1; Type=Frameshift; Positions=213, 244, 267, 282; Evidence={ECO:0000305}; Sequence=BAB55120.1; Type=Erroneous termination; Positions=500; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK5RAP1 Gene

neXtProt entry for CDK5RAP1 Gene

Proteomics data for CDK5RAP1 Gene at MOPED

Post-translational modifications for CDK5RAP1 Gene

  • Ubiquitination at Lys70, Lys378, and Lys546
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CDK5RAP1 Gene

Domains for CDK5RAP1 Gene

Suggested Antigen Peptide Sequences for CDK5RAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SZ6

UniProtKB/Swiss-Prot:

CK5P1_HUMAN :
  • Q96SZ6
Domain:
  • Contains 1 MTTase N-terminal domain.
  • Contains 1 TRAM domain.
Family:
  • Belongs to the methylthiotransferase family. MiaB subfamily.
genes like me logo Genes that share domains with CDK5RAP1: view

No data available for Gene Families for CDK5RAP1 Gene

Function for CDK5RAP1 Gene

Molecular function for CDK5RAP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically inhibits CDK5 activation by CDK5R1

Gene Ontology (GO) - Molecular Function for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016740 transferase activity IEA --
GO:0019901 protein kinase binding NAS 10721722
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDK5RAP1: view

Animal Model Products

CRISPR Products

miRNA for CDK5RAP1 Gene

miRTarBase miRNAs that target CDK5RAP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK5RAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK5RAP1 Gene

Localization for CDK5RAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK5RAP1 Gene COMPARTMENTS Subcellular localization image for CDK5RAP1 gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK5RAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK5RAP1 Gene

Pathways for CDK5RAP1 Gene

SuperPathways for CDK5RAP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0006400 tRNA modification IEA --
GO:0007420 brain development NAS 10915792
GO:0009451 RNA modification --
GO:0043412 macromolecule modification --
genes like me logo Genes that share ontologies with CDK5RAP1: view

No data available for Pathways by source for CDK5RAP1 Gene

Compounds for CDK5RAP1 Gene

(1) HMDB Compounds for CDK5RAP1 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with CDK5RAP1: view

Transcripts for CDK5RAP1 Gene

Unigene Clusters for CDK5RAP1 Gene

CDK5 regulatory subunit associated protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK5RAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: -
SP16: - - - - - -
SP17: - - - - - - - - - - - -
SP18:
SP19: - - -
SP20: - - - -
SP21:

ExUns: 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK5RAP1 Gene

GeneLoc Exon Structure for
CDK5RAP1
ECgene alternative splicing isoforms for
CDK5RAP1

Expression for CDK5RAP1 Gene

mRNA expression in normal human tissues for CDK5RAP1 Gene

Protein differential expression in normal tissues for CDK5RAP1 Gene

This gene is overexpressed in Cerebrospinal fluid (54.9) and Plasma (14.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK5RAP1 Gene

SOURCE GeneReport for Unigene cluster for CDK5RAP1 Gene Hs.435952

mRNA Expression by UniProt/SwissProt for CDK5RAP1 Gene

Q96SZ6-CK5P1_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with CDK5RAP1: view

Expression partners for CDK5RAP1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK5RAP1 Gene

Orthologs for CDK5RAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK5RAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK5RAP1 35
  • 89.21 (n)
  • 89.78 (a)
CDK5RAP1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK5RAP1 35
  • 89 (n)
  • 91.24 (a)
CDK5RAP1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk5rap1 35
  • 85.98 (n)
  • 88.03 (a)
Cdk5rap1 16
Cdk5rap1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK5RAP1 35
  • 98.86 (n)
  • 99.15 (a)
CDK5RAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk5rap1 35
  • 85.91 (n)
  • 86.94 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK5RAP1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK5RAP1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK5RAP1 35
  • 76.49 (n)
  • 82.11 (a)
CDK5RAP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK5RAP1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5rap1 35
  • 67.99 (n)
  • 68.71 (a)
Str.13196 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12738 35
zebrafish
(Danio rerio)
Actinopterygii zgc:162738 35
  • 63.11 (n)
  • 68 (a)
CDK5RAP1 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.505 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012104 35
  • 55.79 (n)
  • 59.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6345 35
  • 56.36 (n)
  • 55.87 (a)
CG6345 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25B5.5 35
  • 55.08 (n)
  • 51.69 (a)
F25B5.5 36
  • 49 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G36390 35
  • 55.42 (n)
  • 53.33 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1217 35
rice
(Oryza sativa)
Liliopsida Os11g0592800 35
  • 56.7 (n)
  • 53.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for CDK5RAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5RAP1 Gene

ENSEMBL:
Gene Tree for CDK5RAP1 (if available)
TreeFam:
Gene Tree for CDK5RAP1 (if available)

Paralogs for CDK5RAP1 Gene

Paralogs for CDK5RAP1 Gene

genes like me logo Genes that share paralogs with CDK5RAP1: view

Variants for CDK5RAP1 Gene

Sequence variations from dbSNP and Humsavar for CDK5RAP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs150373 -- 33,384,736(-) tttgt(A/G)gagat intron-variant
rs158675 -- 33,393,955(-) TGGCT(A/G)TCTAT intron-variant
rs158676 -- 33,386,589(+) AAATC(A/G)CTCTC intron-variant
rs184110 -- 33,393,626(-) ACTCC(C/T)ATCAG intron-variant
rs186026 -- 33,364,187(+) aaata(G/T)ctttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK5RAP1 Gene

Variant ID Type Subtype PubMed ID
nsv819750 CNV Loss 19587683

Relevant External Links for CDK5RAP1 Gene

HapMap Linkage Disequilibrium report
CDK5RAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5RAP1 Gene

Disorders for CDK5RAP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CDK5RAP1 Gene in MalaCards »

(1) Diseases for CDK5RAP1 Gene including...

(1) University of Copenhagen DISEASES for CDK5RAP1 Gene

Relevant External Links for CDK5RAP1

Genetic Association Database (GAD)
CDK5RAP1
Human Genome Epidemiology (HuGE) Navigator
CDK5RAP1
genes like me logo Genes that share disorders with CDK5RAP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CDK5RAP1 Gene

Publications for CDK5RAP1 Gene

  1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PMID: 10721722) Ching Y.-P. … Wang J.H. (Gene 2000) 2 3 4 23
  2. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PMID: 11882646) Ching Y.-P. … Wang J.H. (J. Biol. Chem. 2002) 2 3 4
  3. Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PMID: 15329498) Zou X. … Mao Y. (Genes Genet. Syst. 2004) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CDK5RAP1 Gene

Sources for CDK5RAP1 Gene

Back to Top

Content