Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK5RAP1 Gene

protein-coding   GIFtS: 54
GCID: GC20M031946

CDK5 Regulatory Subunit Associated Protein 1

(Previous name: chromosome 20 open reading frame 34)
(Previous symbol: C20orf34)
  See related diseases
at
MalaCards
 

Aliases
for CDK5RAP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
CDK5 Regulatory Subunit Associated Protein 11 2     C422
C20orf341 2 3     CGI-052
CDK5 Activator-Binding Protein C422 3     HSPC1672
Chromosome 20 Open Reading Frame 341     CDK5 Regulatory Subunit-Associated Protein 12

External Ids:    HGNC: 158801   Entrez Gene: 516542   Ensembl: ENSG000001013917   OMIM: 6082005   UniProtKB: Q96SZ63   

Export aliases for CDK5RAP1 gene to outside databases

Previous GC identifers: GC20M031705 GC20M032615 GC20M032662 GC20M031410 GC20M028734


Summaries
for CDK5RAP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK5RAP1 Gene:
This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify
RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an
inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants
that encode different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for CDK5RAP1 Gene: 
CDK5RAP1 (CDK5 regulatory subunit associated protein 1) is a protein-coding gene. Diseases associated with CDK5RAP1 include mikulicz disease, and narcolepsy. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and protein kinase binding. An important paralog of this gene is CDKAL1.

UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6
Function: Specifically inhibits CDK5 activation by CDK5R1

Gene Wiki entry for CDK5RAP1 Gene


Genomic Views
for CDK5RAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK5RAP1 gene promoter:
         Max1   ISGF-3   STAT1   AML1a   Pax-5   STAT1beta   Arnt   GATA-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK5RAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK5RAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5RAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

CDK5RAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5RAP1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M031946:  view genomic region     (about GC identifiers)

Start:
 31,946,645 bp from pter      End:
 31,989,367 bp from pter
Size:
 42,723 bases      Orientation:
 minus strand

Proteins
for CDK5RAP1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6 (See protein sequence)
Recommended Name: CDK5 regulatory subunit-associated protein 1  
Size: 601 amino acids; 67689 Da
Cofactor: Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine (By similarity)
Subunit: Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1.
Forms a complex with CDK5R1 and CDK5
Sequence caution: Sequence=AAD34147.1; Type=Frameshift; Positions=3, 32, 128, 133, 569; Sequence=AAF29131.1;
Type=Frameshift; Positions=213, 244, 267, 282; Sequence=BAB55120.1; Type=Erroneous termination; Positions=500;
Note=Translated as Glu;
Secondary accessions: A8K7R0 Q5QP46 Q5QP47 Q5QP48 Q9BVG6 Q9BWZ5 Q9H859 Q9NZZ9 Q9Y3F0
Alternative splicing: 4 isoforms:  Q96SZ6-1   Q96SZ6-2   Q96SZ6-3   Q96SZ6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK5RAP1: NX_Q96SZ6

Explore proteomics data for CDK5RAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96SZ6

    • CDK5RAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK5RAP1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001265096.1  NP_001265097.1  NP_001265098.1  NP_057166.4  NP_057492.2  

    ENSEMBL proteins: 
     ENSP00000409474   ENSP00000217372   ENSP00000350558   ENSP00000341840   ENSP00000408133  
     ENSP00000439034  

    Human Recombinant Protein Products for CDK5RAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDK5RAP1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CDK5RAP1
    GenScript Custom Purified and Recombinant Proteins Services for CDK5RAP1
    Novus Biologicals CDK5RAP1 Proteins
    Novus Biologicals CDK5RAP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK5RAP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    CDK5RAP1 for ontologies           About GeneDecksing



    CDK5RAP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDK5RAP1
    GenScript Custom Superior Antibodies Services for CDK5RAP1
    Novus Biologicals CDK5RAP1 Antibodies
    Abcam antibodies for CDK5RAP1
    Cloud-Clone Corp. Antibodies for CDK5RAP1 
    ThermoFisher Antibody for CDK5RAP1
    LSBio Antibodies in human, mouse, rat for CDK5RAP1 

    Assay Products for CDK5RAP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK5RAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK5RAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK5RAP1 
    Cloud-Clone Corp. CLIAs for CDK5RAP1

    Protein Domains /
    Families
    for CDK5RAP1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 5/9 InterPro protein domains (see all 9):
     IPR005839 Methylthiotransferase
     IPR023970 MeThioTfrase/rSAM
     IPR020612 Methylthiotransferase_CS
     IPR013848 Methylthiotransferase_N
     IPR007197 rSAM

    Graphical View of Domain Structure for InterPro Entry Q96SZ6

    ProtoNet protein and cluster: Q96SZ6

    3 Blocks protein domains:
    IPB002792 Deoxyribonuclease/rho motif-related TRAM
    IPB005839 Protein of unknown function UPF0004
    IPB006638 Elongator protein 3/MiaB/NifB


    UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6
    Similarity: Belongs to the methylthiotransferase family. MiaB subfamily
    Similarity: Contains 1 MTTase N-terminal domain
    Similarity: Contains 1 TRAM domain


    CDK5RAP1 for domains           About GeneDecksing


    Function
    for CDK5RAP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CK5P1_HUMAN, Q96SZ6
    Function: Specifically inhibits CDK5 activation by CDK5R1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0016740transferase activity IEA--
    GO:0019901protein kinase binding NAS10721722
    GO:0032403protein complex binding IEA--
    GO:0046872metal ion binding IEA--
         
    CDK5RAP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK5RAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK5RAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK5RAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK5RAP1 

    miRNA
    Products:            		miRTarBase miRNAs that target CDK5RAP1:
    hsa-mir-16 (MIRT001473)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK5RAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CDK5RAP1
    SwitchGear 3'UTR luciferase reporter plasmid: CDK5RAP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK5RAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5RAP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK5RAP1
    Sirion Biotech Customized adenovirus for overexpression of CDK5RAP1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK5RAP1 (see all 11)
    OriGene ORF clones in mouse, rat for CDK5RAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5RAP1 (NM_016082)
    Sino Biological Human cDNA Clone for CDK5RAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5RAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5RAP1
    Sirion Biotech Customized lentivirus for stable overexpression of CDK5RAP1 
                         Customized lentivirus expression plasmids for stable overexpression of CDK5RAP1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK5RAP1
    Search LifeMap BioReagents cell lines for CDK5RAP1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5RAP1


    Pathways & Interactions
    for CDK5RAP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK5RAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for CDK5RAP1 (Q96SZ61, 3 ENSP000002173724) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT41, 3, ENSP000002212334EBI-372956,EBI-371876 I2D: score=2 STRING: ENSP00000221233
    EXOSC3Q9NQT51, 3, ENSP000003230464EBI-372956,EBI-371866 I2D: score=2 STRING: ENSP00000323046
    CDK5R1Q150783, ENSP000003184864I2D: score=2 STRING: ENSP00000318486
    CDK5Q005353, ENSP000002975184I2D: score=1 STRING: ENSP00000297518
    UVRAGQ9P2Y53I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0006400tRNA modification IEA--
    GO:0007420brain development NAS10915792
    GO:0009451RNA modification ----
    GO:0043412macromolecule modification ----

    CDK5RAP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK5RAP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK5RAP1 (CK5P1)

    1 HMDB Compound for CDK5RAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Search CenterWatch for drugs/clinical trials and news about CDK5RAP1 / CK5P1

    Transcripts
    for CDK5RAP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK5RAP1 gene (5 alternative transcripts): 
    NM_001278167.1  NM_001278168.1  NM_001278169.1  NM_016082.4  NM_016408.3  

    Unigene Cluster for CDK5RAP1:

    CDK5 regulatory subunit associated protein 1
    Hs.435952  [show with all ESTs]
    Unigene Representative Sequence: NM_016408
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427097 ENST00000481964 ENST00000482967 ENST00000473997 ENST00000346416(uc002wyz.3 uc002wza.3 uc002wzc.1)
    ENST00000357886(uc010gek.3) ENST00000339269(uc010gem.3 uc010gen.3)
    ENST00000461710(uc002wzb.1) ENST00000498525 ENST00000496381 ENST00000460043
    ENST00000471264 ENST00000473791 ENST00000477105 ENST00000461356 ENST00000488723
    ENST00000452723(uc002wyy.3 uc010gel.3) ENST00000544843
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK5RAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CDK5RAP1
    SwitchGear 3'UTR luciferase reporter plasmid: CDK5RAP1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK5RAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5RAP1
    Clone
    Products:             		 OriGene clones in human, mouse for CDK5RAP1 (see all 11)
    OriGene ORF clones in mouse, rat for CDK5RAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5RAP1 (NM_016082)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5RAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5RAP1
    Sirion Biotech Customized lentivirus for stable overexpression of CDK5RAP1 
                         Customized lentivirus expression plasmids for stable overexpression of CDK5RAP1 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for CDK5RAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK5RAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5RAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5RAP1

    Additional mRNA sequence: 

    AF161516.1 AK023992.1 AK027449.1 AK222745.1 AK292075.1 AK295342.1 AK309906.1 AK314532.1 
    AY462283.1 AY462284.1 BC001215.1 BC050706.1 

    20 DOTS entries:

    DT.214174  DT.100794395  DT.95172064  DT.101981101  DT.102822744  DT.120807552  DT.100036777  DT.99938826 
    DT.100709137  DT.100794393  DT.102822743  DT.100036773  DT.100036775  DT.120807581  DT.120807609  DT.120807630 
    DT.432723  DT.91742063  DT.97780922  DT.100794392 

    24/235 AceView cDNA sequences (see all 235):

    AW250378 AI298397 BQ882845 BC050706 BM981637 CA944982 BU634511 AI123318 
    BE645309 BQ424958 NM_016082 AI005330 BU625454 CA307792 AY462283 BM770513 
    BM757027 AA706470 BM927794 BM713151 BE385082 BM741197 BM756882 AU104054 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP1 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a ·
    SP1:                          -                                               -                 -     -                                                     -   
    SP2:                          -                                               -                 -     -                                                     -   
    SP3:                          -     -                                         -                 -     -                                                     -   
    SP4:                          -                                               -                 -     -                                                     -   
    SP5:                          -                                               -                 -     -     -     -     -     -     -     -                 -   

    ExUns: 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
    SP1:                                -     -         
    SP2:                                -     -         
    SP3:                                -     -         
    SP4:                                                
    SP5:                                -     -         


    ECgene alternative splicing isoforms for CDK5RAP1

    Expression
    for CDK5RAP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK5RAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTGGAGA
    CDK5RAP1 Expression
    About this image


    See CDK5RAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK5RAP1

    SOURCE GeneReport for Unigene cluster: Hs.435952

    UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6
    Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney
    and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including CDK5RAP1: 
              Cell Cycle in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for CDK5RAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK5RAP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5RAP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5RAP1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5RAP1

    Orthologs
    for CDK5RAP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK5RAP1 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdk5rap11 , 5 CDK5 regulatory subunit associated protein 11, 5 85.87(n)1
    88.03(a)1    		   2 (76.46 cM)5
    669711  NM_025876.21  NP_080152.11 
     1543353805 
    chicken
    (Gallus gallus)    		 Aves CDK5RAP11 CDK5 regulatory subunit associated protein 1 74.73(n)
    79.27(a)    		   419292  XM_417464.3  XP_417464.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK5RAP16
    		 Uncharacterized protein
    		 66(a)
    		 1 ↔ 1
    		 GL343886.1(26074-51372)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.127382 Xenopus laevis transcribed sequence with weak similarity more 78.63(n)    BJ073828.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1627381 zgc:162738 63.22(n)
    68.26(a)    		   558659  NM_001110379.1  NP_001103849.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG63451 CG6345 56.36(n)
    55.87(a)    		   41271  NM_141745.3  NP_650002.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F25B5.51 Protein F25B5.5 55.11(n)
    51.62(a)    		   175841  NM_065889.4  NP_498290.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G363901 Methylthiotransferase 53.84(n)
    51.72(a)    		   829791  NM_119802.2  NP_195357.2 
    rice
    (Oryza sativa)    		 Liliopsida Os11g05928001 hypothetical protein 56.7(n)
    53.64(a)    		   4350829  NM_001074728.1  NP_001068196.1 


    ENSEMBL Gene Tree for CDK5RAP1 (if available)
    TreeFam Gene Tree for CDK5RAP1 (if available)

    Paralogs
    for CDK5RAP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK5RAP1 gene
    CDKAL12  

    CDK5RAP1 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK5RAP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/924 SNPs in CDK5RAP1 are shown (see all 924)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs130382011,2
    		C,F,H--31946260(+) GGGGGT/CTGTAA 5 -- ds50017Minor allele frequency- C:0.00NS EA NA 616
    rs1878092891,2
    		--31946272(+) GGAAAA/GCAGAG 5 -- ds50010--------
    rs1475841791,2
    		C--31946397(+) TGCAGC/TGATAG 5 -- ds50010--------
    rs775403071,2
    		F--31946410(+) AGCTAA/TGTCAG 5 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1420926111,2
    		C--31946445(+) AGGTCA/GAGAGC 5 -- ds50010--------
    rs171246401,2
    		C,F--31946537(+) GGGAGC/AAGTGT 5 -- ds50015Minor allele frequency- A:0.01NA 144
    rs1169179001,2
    		F--31946620(+) AAAAAC/TGAAGT 5 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1389126601,2
    		--31946630(+) TCAAAC/GTGAGA 5 -- ds50010--------
    rs1179883031,2
    		F--31946631(+) CAAAGT/GGAGAG 5 -- ds50011Minor allele frequency- G:0.07EA 120
    rs171246421,2
    		C,F,H--31946661(+) TTAGGT/AAAATT 5 -- ut31 ese39Minor allele frequency- A:0.08NA NS EA WA 658

    HapMap Linkage Disequilibrium report for CDK5RAP1 (31946645 - 31989367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK5RAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819750CNV Loss19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK5RAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5RAP1

    Disorders / Diseases
    for CDK5RAP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 608200    OMIM disorders: --

    4 diseases for CDK5RAP1:    About MalaCards
    mikulicz disease    narcolepsy    neuronitis    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for CDK5RAP1:
    Mikulicz disease

    CDK5RAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK5RAP1
    Human Genome Epidemiology (HuGE) Navigator: CDK5RAP1 (4 documents)

    Export disorders for CDK5RAP1 gene to outside databases

    Publications
    for CDK5RAP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK5RAP1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CDK5RAP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PubMed id 10721722)1, 2, 3, 9 Ching Y.-P.... Wang J.H. (2000)
    2. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PubMed id 11882646)1, 2, 3 Ching Y.-P.... Wang J.H. (2002)
    3. Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (2010)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PubMed id 15329498)1, 3 Zou X....Mao Y. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)

    External Searches for CDK5RAP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK5RAP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51654 HGNC: 15880 AceView: CDK5RAP1 Ensembl:ENSG00000101391 euGenes: HUgn51654
    ECgene: CDK5RAP1 H-InvDB: CDK5RAP1

    Other Databases showing CDK5RAP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK5RAP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK5RAP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDK5RAP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK5RAP1 gene:
    Search GeneIP for patents involving CDK5RAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK5RAP1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CDK5RAP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDK5RAP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDK5RAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK5RAP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CDK5RAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK5RAP1   OriGene Custom Protein Services for CDK5RAP1  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK5RAP1
     QIAGEN SeqTarget long-range PCR primers for resequencing CDK5RAP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5RAP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5RAP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5RAP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5RAP1
     GenScript Custom Purified and Recombinant Proteins Services for CDK5RAP1 GenScript cDNA clones with any tag delivered in your preferred vector for CDK5RAP1
     GenScript Custom Assay Services for CDK5RAP1 GenScript Custom Superior Antibodies Services for CDK5RAP1
     GenScript Custom overexpressing Cell Line Services for CDK5RAP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDK5RAP1 promoter
     Search Chromatin IP Primers for CDK5RAP1
     RT2 qPCR Primer Assay in human, mouse, rat CDK5RAP1
     Search GNC Networks for CDK5RAP1
     SABiosciences PCR Arrays including human, mouse, rat CDK5RAP1
     Search Tocris compounds for CDK5RAP1 (CK5P1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CDK5RAP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK5RAP1 antibodies
     CDK5RAP1 proteins
     CDK5RAP1 lysates
     Antibodies for CDK5RAP1
     See all of Abcam's Antibodies, Kits and Proteins for CDK5RAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CDK5RAP1
     Antibodies for CDK5RAP1
     ELISAs for CDK5RAP1
     CLIAs for CDK5RAP1
     Search LifeMap BioReagents cell lines for CDK5RAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5RAP1
     SwitchGear 3'UTR luciferase reporter plasmids for CDK5RAP1
     SwitchGear Promoter luciferase reporter plasmids for CDK5RAP1
     ThermoFisher Antibody for CDK5RAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5RAP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK5RAP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK5RAP1
    Customized:
     lentivirus for stable overexpression of CDK5RAP1
     lentivirus expression plasmids for stable overexpression of CDK5RAP1
     adenovirus for overexpression of CDK5RAP1
     LSBio Antibodies in human, mouse, rat for CDK5RAP1
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CDK5RAP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4