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CDK5RAP1 Gene

protein-coding   GIFtS: 54
GCID: GC20M031946

CDK5 Regulatory Subunit Associated Protein 1

(Previous name: chromosome 20 open reading frame 34)
(Previous symbol: C20orf34)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDK5 Regulatory Subunit Associated Protein 11 2     C422
C20orf341 2 3     CGI-052
CDK5 Activator-Binding Protein C422 3     HSPC1672
Chromosome 20 Open Reading Frame 341     CDK5 Regulatory Subunit-Associated Protein 12

External Ids:    HGNC: 158801   Entrez Gene: 516542   Ensembl: ENSG000001013917   OMIM: 6082005   UniProtKB: Q96SZ63   

Export aliases for CDK5RAP1 gene to outside databases

Previous GC identifers: GC20M031705 GC20M032615 GC20M032662 GC20M031410 GC20M028734


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK5RAP1 Gene:
This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify
RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an
inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants
that encode different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for CDK5RAP1 Gene:
CDK5RAP1 (CDK5 regulatory subunit associated protein 1) is a protein-coding gene. Diseases associated with CDK5RAP1 include mikulicz disease, and narcolepsy. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and protein kinase binding. An important paralog of this gene is CDKAL1.

UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6
Function: Specifically inhibits CDK5 activation by CDK5R1

Gene Wiki entry for CDK5RAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK5RAP1 gene promoter:
         Max1   ISGF-3   STAT1   AML1a   Pax-5   STAT1beta   Arnt   GATA-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK5RAP1 promoter sequence
   Search Chromatin IP Primers for CDK5RAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5RAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

CDK5RAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5RAP1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M031946:  view genomic region     (about GC identifiers)

Start:
31,946,645 bp from pter      End:
31,989,367 bp from pter
Size:
42,723 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6 (See protein sequence)
Recommended Name: CDK5 regulatory subunit-associated protein 1  
Size: 601 amino acids; 67689 Da
Cofactor: Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine (By similarity)
Subunit: Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1.
Forms a complex with CDK5R1 and CDK5
Sequence caution: Sequence=AAD34147.1; Type=Frameshift; Positions=3, 32, 128, 133, 569; Sequence=AAF29131.1;
Type=Frameshift; Positions=213, 244, 267, 282; Sequence=BAB55120.1; Type=Erroneous termination; Positions=500;
Note=Translated as Glu;
Secondary accessions: A8K7R0 Q5QP46 Q5QP47 Q5QP48 Q675N4 Q675N5 Q9BVG6 Q9BWZ5 Q9H859 Q9NZZ9
Q9Y3F0
Alternative splicing: 6 isoforms:  Q96SZ6-1   Q96SZ6-2   Q96SZ6-3   Q96SZ6-4   Q96SZ6-5   Q96SZ6-6   (High expression in placenta and lung)

Explore the universe of human proteins at neXtProt for CDK5RAP1: NX_Q96SZ6

Explore proteomics data for CDK5RAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys70, Lys378, Lys546
  • Modification sites at PhosphoSitePlus

  • See CDK5RAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265096.1  NP_001265097.1  NP_001265098.1  NP_057166.4  NP_057492.2  

    ENSEMBL proteins: 
     ENSP00000409474   ENSP00000476857   ENSP00000217372   ENSP00000350558   ENSP00000341840  
     ENSP00000439034  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR005839 Methylthiotransferase
     IPR023970 MeThioTfrase/rSAM
     IPR020612 Methylthiotransferase_CS
     IPR013848 Methylthiotransferase_N
     IPR007197 rSAM

    Graphical View of Domain Structure for InterPro Entry Q96SZ6

    ProtoNet protein and cluster: Q96SZ6

    3 Blocks protein domains:
    IPB002792 Deoxyribonuclease/rho motif-related TRAM
    IPB005839 Protein of unknown function UPF0004
    IPB006638 Elongator protein 3/MiaB/NifB


    UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6
    Similarity: Belongs to the methylthiotransferase family. MiaB subfamily
    Similarity: Contains 1 MTTase N-terminal domain
    Similarity: Contains 1 TRAM domain


    CDK5RAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CK5P1_HUMAN, Q96SZ6
    Function: Specifically inhibits CDK5 activation by CDK5R1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0016740transferase activity IEA--
    GO:0019901protein kinase binding NAS10721722
    GO:0032403protein complex binding IEA--
    GO:0046872metal ion binding IEA--
         
    CDK5RAP1 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    CDK5RAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CDK5RAP1: 
              Cell Cycle in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDK5RAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CDK5RAP1 (Q96SZ61, 3 ENSP000002173724) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT41, 3, ENSP000002212334EBI-372956,EBI-371876 I2D: score=2 STRING: ENSP00000221233
    EXOSC3Q9NQT51, 3, ENSP000003230464EBI-372956,EBI-371866 I2D: score=2 STRING: ENSP00000323046
    CDK5R1Q150783, ENSP000003184864I2D: score=2 STRING: ENSP00000318486
    CDK5Q005353, ENSP000002975184I2D: score=1 STRING: ENSP00000297518
    UVRAGQ9P2Y53I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0006400tRNA modification IEA--
    GO:0007420brain development NAS10915792
    GO:0009451RNA modification ----
    GO:0043412macromolecule modification ----

    CDK5RAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDK5RAP1 (CK5P1)

    1 HMDB Compound for CDK5RAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK5RAP1 gene (5 alternative transcripts): 
    NM_001278167.1  NM_001278168.1  NM_001278169.1  NM_016082.4  NM_016408.3  

    Unigene Cluster for CDK5RAP1:

    CDK5 regulatory subunit associated protein 1
    Hs.435952  [show with all ESTs]
    Unigene Representative Sequence: NM_016408
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427097 ENST00000481964 ENST00000482967 ENST00000473997 ENST00000346416(uc002wyz.3 uc002wza.3 uc002wzc.1)
    ENST00000357886(uc010gek.3) ENST00000339269(uc010gem.3 uc010gen.3)
    ENST00000461710(uc002wzb.1) ENST00000498525 ENST00000496381 ENST00000460043
    ENST00000471264 ENST00000473791 ENST00000477105 ENST00000461356 ENST00000488723
    ENST00000544843
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    Additional mRNA sequence: 

    AF161516.1 AK023992.1 AK027449.1 AK222745.1 AK292075.1 AK295342.1 AK309906.1 AK314532.1 
    AY462283.1 AY462284.1 BC001215.1 BC050706.1 

    20 DOTS entries:

    DT.214174  DT.100794395  DT.95172064  DT.101981101  DT.102822744  DT.120807552  DT.100036777  DT.99938826 
    DT.100709137  DT.100794393  DT.102822743  DT.100036773  DT.100036775  DT.120807581  DT.120807609  DT.120807630 
    DT.432723  DT.91742063  DT.97780922  DT.100794392 

    Selected AceView cDNA sequences (see all 235):

    AA723454 AI005330 CR592631 BQ424958 AW250378 BU625454 NM_016082 BQ882845 
    BE393850 CA489121 BG875910 CA306925 CB127568 AI474982 CA944982 BM770513 
    BM756882 AW246779 BM741197 BQ316396 AW189626 BU629184 BM786720 BM757027 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP1 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a ·
    SP1:                          -                                               -                 -     -                                                     -   
    SP2:                          -                                               -                 -     -                                                     -   
    SP3:                          -     -                                         -                 -     -                                                     -   
    SP4:                          -                                               -                 -     -                                                     -   
    SP5:                          -                                               -                 -     -     -     -     -     -     -     -                 -   

    ExUns: 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
    SP1:                                -     -         
    SP2:                                -     -         
    SP3:                                -     -         
    SP4:                                                
    SP5:                                -     -         


    ECgene alternative splicing isoforms for CDK5RAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK5RAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTGGAGA
    CDK5RAP1 Expression
    About this image

    CDK5RAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK5RAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435952

    UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6
    Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney
    and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including CDK5RAP1: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK5RAP1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk5rap11 , 5 CDK5 regulatory subunit associated protein 11, 5 85.98(n)1
    88.03(a)1
      2 (76.46 cM)5
    669711  NM_025876.21  NP_080152.11 
     1543353805 
    chicken
    (Gallus gallus)
    Aves CDK5RAP11 CDK5 regulatory subunit associated protein 1 76.49(n)
    82.11(a)
      419292  XM_417464.4  XP_417464.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK5RAP16
    CDK5 regulatory subunit associated protein 1
    66(a)
    1 ↔ 1
    GL343886.1(26074-51372)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127382 Xenopus laevis transcribed sequence with weak similarity more 78.63(n)    BJ073828.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1627381 zgc:162738 63.11(n)
    68(a)
      558659  NM_001110379.1  NP_001103849.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63451 CG6345 56.36(n)
    55.87(a)
      41271  NM_141745.4  NP_650002.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F25B5.51 F25B5.5 55.08(n)
    51.69(a)
      175841  NM_065889.5  NP_498290.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G363901 AT4G36390 55.42(n)
    53.33(a)
      829791  NM_119802.2  NP_195357.2 
    rice
    (Oryza sativa)
    Liliopsida Os11g05928001 Os11g0592800 56.7(n)
    53.64(a)
      4350829  NM_001074728.1  NP_001068196.1 


    ENSEMBL Gene Tree for CDK5RAP1 (if available)
    TreeFam Gene Tree for CDK5RAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK5RAP1 gene
    CDKAL12  

    CDK5RAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK5RAP1 (see all 924)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130382011,2
    C,F,H--31946260(+) GGGGGT/CTGTAA 5 -- ds50017Minor allele frequency- C:0.00NS EA NA 616
    rs1878092891,2
    --31946272(+) GGAAAA/GCAGAG 5 -- ds50010--------
    rs1475841791,2
    C--31946397(+) TGCAGC/TGATAG 5 -- ds50010--------
    rs775403071,2
    F--31946410(+) AGCTAA/TGTCAG 5 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1420926111,2
    C--31946445(+) AGGTCA/GAGAGC 5 -- ds50010--------
    rs171246401,2
    C,F--31946537(+) GGGAGC/AAGTGT 5 -- ds50015Minor allele frequency- A:0.01NA 144
    rs1169179001,2
    F--31946620(+) AAAAAC/TGAAGT 5 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1389126601,2
    --31946630(+) TCAAAC/GTGAGA 5 -- ds50010--------
    rs1179883031,2
    F--31946631(+) CAAAGT/GGAGAG 5 -- ds50011Minor allele frequency- G:0.07EA 120
    rs171246421,2
    C,F,H--31946661(+) TTAGGT/AAAATT 5 -- ut31 ese39Minor allele frequency- A:0.08NA NS EA WA 658

    HapMap Linkage Disequilibrium report for CDK5RAP1 (31946645 - 31989367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK5RAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819750CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK5RAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5RAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608200    OMIM disorders: --

    6 diseases for CDK5RAP1:    
    About MalaCards
    mikulicz disease    narcolepsy    vitiligo    tuberculosis
    neuronitis    malaria

    1 disease from the University of Copenhagen DISEASES database for CDK5RAP1:
    Mikulicz disease

    CDK5RAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK5RAP1
    Human Genome Epidemiology (HuGE) Navigator: CDK5RAP1 (4 documents)

    Export disorders for CDK5RAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK5RAP1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with CDK5RAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PubMed id 10721722)1, 2, 3, 9 Ching Y.-P.... Wang J.H. (Gene 2000)
    2. Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PubMed id 15329498)1, 2, 3 Zou X.... Mao Y. (Genes Genet. Syst. 2004)
    3. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PubMed id 11882646)1, 2, 3 Ching Y.-P.... Wang J.H. (J. Biol. Chem. 2002)
    4. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (PLoS Genet. 2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51654 HGNC: 15880 AceView: CDK5RAP1 Ensembl:ENSG00000101391 euGenes: HUgn51654
    ECgene: CDK5RAP1 H-InvDB: CDK5RAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK5RAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK5RAP1 gene:
    Search GeneIP for patents involving CDK5RAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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