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CDK5RAP1 Gene(Protein Coding)

CDK5 Regulatory Subunit Associated Protein 1

GCID:
GC20M033358
GIFtS:
53
Genes Participants
UDN Logo

Aliases for CDK5RAP1 Gene

Aliases for CDK5RAP1 Gene

  • CDK5 Regulatory Subunit Associated Protein 1 2 3 5
  • CDK5 Activator-Binding Protein C42 3 4
  • C20orf34 3 4
  • Chromosome 20 Open Reading Frame 34 2
  • HSPC167 3
  • CGI-05 3
  • C42 3

External Ids for CDK5RAP1 Gene

Previous HGNC Symbols for CDK5RAP1 Gene

  • C20orf34

Previous GeneCards Identifiers for CDK5RAP1 Gene

  • GC20M031705
  • GC20M032615
  • GC20M032662
  • GC20M031410
  • GC20M031946
  • GC20M028734

Summaries for CDK5RAP1 Gene

Entrez Gene Summary for CDK5RAP1 Gene

  • This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for CDK5RAP1 Gene

CDK5RAP1 (CDK5 Regulatory Subunit Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and transferase activity. An important paralog of this gene is CDKAL1.

UniProtKB/Swiss-Prot for CDK5RAP1 Gene

  • Specifically inhibits CDK5 activation by CDK5R1.

Gene Wiki entry for CDK5RAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5RAP1 Gene

Genomics for CDK5RAP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CDK5RAP1 Gene

Enhancers for CDK5RAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK5RAP1 on UCSC Golden Path with GeneCards custom track

Promoters for CDK5RAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK5RAP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDK5RAP1 gene promoter:

Genomic Location for CDK5RAP1 Gene

Chromosome:
20
Start:
33,358,839 bp from pter
End:
33,401,902 bp from pter
Size:
43,064 bases
Orientation:
Minus strand

Genomic View for CDK5RAP1 Gene

Genes around CDK5RAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5RAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5RAP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK5RAP1 Gene

Proteins for CDK5RAP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDK5RAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ6-CK5P1_HUMAN
    Recommended name:
    CDK5 regulatory subunit-associated protein 1
    Protein Accession:
    Q96SZ6
    Secondary Accessions:
    • A8K7R0
    • Q5QP46
    • Q5QP47
    • Q5QP48
    • Q675N4
    • Q675N5
    • Q9BVG6
    • Q9BWZ5
    • Q9H859
    • Q9NZZ9
    • Q9Y3F0

    Protein attributes for CDK5RAP1 Gene

    Size:
    601 amino acids
    Molecular mass:
    67689 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.
    SequenceCaution:
    • Sequence=AAD34147.1; Type=Frameshift; Positions=3, 32, 128, 133, 569; Evidence={ECO:0000305}; Sequence=AAF29131.1; Type=Frameshift; Positions=213, 244, 267, 282; Evidence={ECO:0000305}; Sequence=BAB55120.1; Type=Erroneous termination; Positions=500; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK5RAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK5RAP1 Gene

Proteomics data for CDK5RAP1 Gene at MOPED

Protein Expression for CDK5RAP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CDK5RAP1 Gene

  • Ubiquitination at Lys 70 and Lys 378
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK5RAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDK5RAP1 Gene

Domains & Families for CDK5RAP1 Gene

Protein Domains for CDK5RAP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK5RAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SZ6

UniProtKB/Swiss-Prot:

CK5P1_HUMAN :
  • Contains 1 MTTase N-terminal domain.
  • Belongs to the methylthiotransferase family. MiaB subfamily.
Domain:
  • Contains 1 MTTase N-terminal domain.
  • Contains 1 TRAM domain.
Family:
  • Belongs to the methylthiotransferase family. MiaB subfamily.
genes like me logo Genes that share domains with CDK5RAP1: view

No data available for Gene Families for CDK5RAP1 Gene

Function for CDK5RAP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CDK5RAP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically inhibits CDK5 activation by CDK5R1.

Gene Ontology (GO) - Molecular Function for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016740 transferase activity IEA --
GO:0019887 protein kinase regulator activity IBA --
GO:0019901 protein kinase binding NAS 10721722
GO:0035596 NOT methylthiotransferase activity IBA --
genes like me logo Genes that share ontologies with CDK5RAP1: view

Phenotypes for CDK5RAP1 Gene

GenomeRNAi human phenotypes for CDK5RAP1:
genes like me logo Genes that share phenotypes with CDK5RAP1: view

Animal Model Products

CRISPR Products

miRNA for CDK5RAP1 Gene

miRTarBase miRNAs that target CDK5RAP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK5RAP1 Gene

Localization for CDK5RAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK5RAP1 Gene COMPARTMENTS Subcellular localization image for CDK5RAP1 gene
Compartment Confidence
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK5RAP1 Gene

Pathways & Interactions for CDK5RAP1 Gene

SuperPathways for CDK5RAP1 Gene

PathCards logoMore details on SuperPathways for CDK5RAP1
No Data Available

Gene Ontology (GO) - Biological Process for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 11882646
genes like me logo Genes that share ontologies with CDK5RAP1: view

No data available for Pathways by source and SIGNOR curated interactions for CDK5RAP1 Gene

Drugs & Compounds for CDK5RAP1 Gene

Products:

  1. Drug

(1) Drugs for CDK5RAP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with CDK5RAP1: view

Transcripts for CDK5RAP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CDK5RAP1 Gene

(11) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(235) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK5RAP1 Gene

CDK5 regulatory subunit associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: -
SP16: - - - - - -
SP17: - - - - - - - - - - - -
SP18:
SP19: - - -
SP20: - - - -
SP21:

ExUns: 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK5RAP1 Gene

GeneLoc Exon Structure for
CDK5RAP1
ECgene alternative splicing isoforms for
CDK5RAP1

Expression for CDK5RAP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CDK5RAP1 Gene

mRNA expression in normal human tissues for CDK5RAP1 Gene
mRNA expression by BioGPS for CDK5RAP1 GenemRNA expression by GTEx for CDK5RAP1 Gene

Protein differential expression in normal tissues from HIPED for CDK5RAP1 Gene

This gene is overexpressed in Cerebrospinal fluid (54.9) and Plasma (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK5RAP1 Gene



SOURCE GeneReport for Unigene cluster for CDK5RAP1 Gene Hs.435952

mRNA Expression by UniProt/SwissProt for CDK5RAP1 Gene

Q96SZ6-CK5P1_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CDK5RAP1: view

Protein tissue co-expression partners for CDK5RAP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK5RAP1 Gene

Orthologs for CDK5RAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK5RAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CDK5RAP1 35
  • 89.21 (n)
  • 89.78 (a)
CDK5RAP1 36
  • 89 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CDK5RAP1 35
  • 89 (n)
  • 91.24 (a)
CDK5RAP1 36
  • 83 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cdk5rap1 35
  • 85.98 (n)
  • 88.03 (a)
Cdk5rap1 16
Cdk5rap1 36
  • 86 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CDK5RAP1 35
  • 98.86 (n)
  • 99.15 (a)
CDK5RAP1 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cdk5rap1 35
  • 85.91 (n)
  • 86.94 (a)
oppossum
(Monodelphis domestica)
 Mammalia CDK5RAP1 36
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CDK5RAP1 36
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CDK5RAP1 35
  • 76.49 (n)
  • 82.11 (a)
CDK5RAP1 36
  • 74 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CDK5RAP1 36
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdk5rap1 35
  • 67.99 (n)
  • 68.71 (a)
Str.13196 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.12738 35
zebrafish
(Danio rerio)
 Actinopterygii zgc:162738 35
  • 63.11 (n)
  • 68 (a)
CDK5RAP1 36
  • 63 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.505 35
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP012104 35
  • 55.79 (n)
  • 59.07 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG6345 35
  • 56.36 (n)
  • 55.87 (a)
CG6345 36
  • 51 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea F25B5.5 35
  • 55.08 (n)
  • 51.69 (a)
F25B5.5 36
  • 49 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G36390 35
  • 55.42 (n)
  • 53.33 (a)
barley
(Hordeum vulgare)
 Liliopsida Hv.1217 35
rice
(Oryza sativa)
 Liliopsida Os11g0592800 35
  • 56.7 (n)
  • 53.64 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 51 (a)
 OneToOne
Species with no ortholog for CDK5RAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5RAP1 Gene

ENSEMBL:
Gene Tree for CDK5RAP1 (if available)
TreeFam:
Gene Tree for CDK5RAP1 (if available)

Paralogs for CDK5RAP1 Gene

Paralogs for CDK5RAP1 Gene

genes like me logo Genes that share paralogs with CDK5RAP1: view

Variants for CDK5RAP1 Gene

Sequence variations from dbSNP and Humsavar for CDK5RAP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs150373 -- 33,384,736(-) tttgt(A/G)gagat intron-variant
rs158675 -- 33,393,955(-) TGGCT(A/G)TCTAT intron-variant
rs158676 -- 33,386,589(+) AAATC(A/G)CTCTC intron-variant
rs184110 -- 33,393,626(-) ACTCC(C/T)ATCAG intron-variant
rs186026 -- 33,364,187(+) aaata(G/T)ctttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK5RAP1 Gene

Variant ID Type Subtype PubMed ID
nsv819750 CNV Loss 19587683

Variation tolerance for CDK5RAP1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDK5RAP1 Gene

Disorders for CDK5RAP1 Gene

Relevant External Links for CDK5RAP1

Genetic Association Database (GAD)
CDK5RAP1
Human Genome Epidemiology (HuGE) Navigator
CDK5RAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK5RAP1

No disorders were found for CDK5RAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK5RAP1 Gene

Publications for CDK5RAP1 Gene

  1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PMID: 10721722) Ching Y.-P. … Wang J.H. (Gene 2000) 2 3 4 23 67
  2. Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PMID: 15329498) Zou X. … Mao Y. (Genes Genet. Syst. 2004) 2 3
  3. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PMID: 11882646) Ching Y.-P. … Wang J.H. (J. Biol. Chem. 2002) 2 3
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  5. CDK5RAP1 deficiency induces cell cycle arrest and apoptosis in human breast cancer cell line by the ROS/JNK signaling pathway. (PMID: 25607831) Wang H. … Li Z. (Oncol. Rep. 2015) 3

Products for CDK5RAP1 Gene

Sources for CDK5RAP1 Gene

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