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CDK5RAP1 Gene

protein-coding GIFtS: 54
GCID: GC20M031946

CDK5 Regulatory Subunit Associated Protein 1

(Previous name: chromosome 20 open reading frame 34)
(Previous symbol: C20orf34)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
CDK5 Regulatory Subunit Associated Protein 1¹ ²		C42²
C20orf34¹ ² ³		CGI-05²
CDK5 Activator-Binding Protein C42² ³		HSPC167²
Chromosome 20 Open Reading Frame 34¹		CDK5 Regulatory Subunit-Associated Protein 1²

External Ids:	HGNC: 15880¹	Entrez Gene: 51654²	Ensembl: ENSG00000101391⁷	OMIM: 608200⁵	UniProtKB: Q96SZ6³

Export aliases for CDK5RAP1 gene to outside databases

Previous GC identifers: GC20M031705 GC20M032615 GC20M032662 GC20M031410 GC20M028734

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK5RAP1 Gene:

This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify

RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an

inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants

that encode different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for CDK5RAP1 Gene:

CDK5RAP1 (CDK5 regulatory subunit associated protein 1) is a protein-coding gene. Diseases associated with CDK5RAP1 include mikulicz disease, and narcolepsy. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and protein kinase binding. An important paralog of this gene is CDKAL1.

UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6

Function: Specifically inhibits CDK5 activation by CDK5R1

Gene Wiki entry for CDK5RAP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000020.11 NC_018931.2 NT_011362.11

Regulatory elements:

Regulatory transcription factor binding sites in the CDK5RAP1 gene promoter:
Max1 ISGF-3 STAT1 AML1a Pax-5 STAT1beta Arnt GATA-1 STAT1alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK5RAP1 promoter sequence

Search Chromatin IP Primers for CDK5RAP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5RAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21

CDK5RAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5RAP1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M031946: view genomic region (about GC identifiers)

Start:	31,946,645 bp from pter	End:	31,989,367 bp from pter
Size:	42,723 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6 (See protein sequence)

Recommended Name: CDK5 regulatory subunit-associated protein 1

Size: 601 amino acids; 67689 Da

Cofactor: Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable

S-adenosyl-L-methionine (By similarity)

Subunit: Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1.

Forms a complex with CDK5R1 and CDK5

Sequence caution: Sequence=AAD34147.1; Type=Frameshift; Positions=3, 32, 128, 133, 569; Sequence=AAF29131.1;

Type=Frameshift; Positions=213, 244, 267, 282; Sequence=BAB55120.1; Type=Erroneous termination; Positions=500;

Note=Translated as Glu;

Secondary accessions: A8K7R0 Q5QP46 Q5QP47 Q5QP48 Q675N4 Q675N5 Q9BVG6 Q9BWZ5 Q9H859 Q9NZZ9

Q9Y3F0

Alternative splicing: 6 isoforms: Q96SZ6-1 Q96SZ6-2 Q96SZ6-3 Q96SZ6-4 Q96SZ6-5 Q96SZ6-6 (High expression in placenta and lung)

Explore the universe of human proteins at neXtProt for CDK5RAP1: NX_Q96SZ6

Explore proteomics data for CDK5RAP1 at MOPED

Post-translational modifications:

Ubiquitination² at Lys70, Lys378, Lys546

Modification sites at PhosphoSitePlus

See CDK5RAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts):

NP_001265096.1 NP_001265097.1 NP_001265098.1 NP_057166.4 NP_057492.2

ENSEMBL proteins:

ENSP00000409474 ENSP00000476857 ENSP00000217372 ENSP00000350558 ENSP00000341840

ENSP00000439034

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 9):

IPR005839 Methylthiotransferase

IPR023970 MeThioTfrase/rSAM

IPR020612 Methylthiotransferase_CS

IPR013848 Methylthiotransferase_N

IPR007197 rSAM

Graphical View of Domain Structure for InterPro Entry Q96SZ6

ProtoNet protein and cluster: Q96SZ6

3 Blocks protein domains:

IPB002792 Deoxyribonuclease/rho motif-related TRAM

IPB005839 Protein of unknown function UPF0004

IPB006638 Elongator protein 3/MiaB/NifB

UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6

Similarity: Belongs to the methylthiotransferase family. MiaB subfamily

Similarity: Contains 1 MTTase N-terminal domain

Similarity: Contains 1 TRAM domain

CDK5RAP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CK5P1_HUMAN, Q96SZ6

Function: Specifically inhibits CDK5 activation by CDK5R1

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0016740	transferase activity	IEA	--
GO:0019901	protein kinase binding	NAS	10721722
GO:0032403	protein complex binding	IEA	--
GO:0046872	metal ion binding	IEA	--

CDK5RAP1 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	1
mitochondrion	1
nucleus	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005737	cytoplasm	IEA	--

CDK5RAP1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Pathway & Disease-focused RT² Profiler PCR Array including CDK5RAP1:

Cell Cycle in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for CDK5RAP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for CDK5RAP1 (Q96SZ6^{1, 3} ENSP00000217372⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOSC5	Q9NQT4¹^,³, ENSP00000221233⁴	EBI-372956,EBI-371876 I2D: score=2 STRING: ENSP00000221233
EXOSC3	Q9NQT5¹^,³, ENSP00000323046⁴	EBI-372956,EBI-371866 I2D: score=2 STRING: ENSP00000323046
CDK5R1	Q15078³, ENSP00000318486⁴	I2D: score=2 STRING: ENSP00000318486
CDK5	Q00535³, ENSP00000297518⁴	I2D: score=1 STRING: ENSP00000297518
UVRAG	Q9P2Y5³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	--	--
GO:0006400	tRNA modification	IEA	--
GO:0007420	brain development	NAS	10915792
GO:0009451	RNA modification	--	--
GO:0043412	macromolecule modification	--	--

CDK5RAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CDK5RAP1 (CK5P1)

1 HMDB Compound for CDK5RAP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CDK5RAP1 gene (5 alternative transcripts):

NM_001278167.1 NM_001278168.1 NM_001278169.1 NM_016082.4 NM_016408.3

Unigene Cluster for CDK5RAP1:

CDK5 regulatory subunit associated protein 1

Hs.435952 [show with all ESTs]

Unigene Representative Sequence: NM_016408

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000427097 ENST00000481964 ENST00000482967 ENST00000473997 ENST00000346416(uc002wyz.3 uc002wza.3 uc002wzc.1)

ENST00000357886(uc010gek.3) ENST00000339269(uc010gem.3 uc010gen.3)

ENST00000461710(uc002wzb.1) ENST00000498525 ENST00000496381 ENST00000460043

ENST00000471264 ENST00000473791 ENST00000477105 ENST00000461356 ENST00000488723

ENST00000544843

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Additional mRNA sequence:

AF161516.1 AK023992.1 AK027449.1 AK222745.1 AK292075.1 AK295342.1 AK309906.1 AK314532.1

AY462283.1 AY462284.1 BC001215.1 BC050706.1

20 DOTS entries:

DT.214174 DT.100794395 DT.95172064 DT.101981101 DT.102822744 DT.120807552 DT.100036777 DT.99938826

DT.100709137 DT.100794393 DT.102822743 DT.100036773 DT.100036775 DT.120807581 DT.120807609 DT.120807630

DT.432723 DT.91742063 DT.97780922 DT.100794392

Selected AceView cDNA sequences (see all 235):

AA723454 AI005330 CR592631 BQ424958 AW250378 BU625454 NM_016082 BQ882845

BE393850 CA489121 BG875910 CA306925 CB127568 AI474982 CA944982 BM770513

BM756882 AW246779 BM741197 BQ316396 AW189626 BU629184 BM786720 BM757027

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP1 (see all 21) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f	^	11a	·	11b	^	12a	·
SP1:									-																-						-		-																		-
SP2:									-																-						-		-																		-
SP3:									-		-														-						-		-																		-
SP4:									-																-						-		-																		-
SP5:									-																-						-		-		-		-		-		-		-		-						-

ExUns:	12b	^	13	^	14	^	15a	·	15b	·	15c	·	15d	^	16
SP1:											-		-
SP2:											-		-
SP3:											-		-
SP4:
SP5:											-		-

ECgene alternative splicing isoforms for CDK5RAP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CDK5RAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGGTGGAGA

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CDK5RAP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CDK5RAP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.435952

UniProtKB/Swiss-Prot: CK5P1_HUMAN, Q96SZ6

Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney

and pancreas

Pathway & Disease-focused RT² Profiler PCR Array including CDK5RAP1:

Cell Cycle in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5RAP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK5RAP1 gene from Selected species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdk5rap1^{1 , 5}	CDK5 regulatory subunit associated protein 1^{1, 5}	85.98(n)¹ 88.03(a)¹		2 (76.46 cM)⁵ 66971¹ NM_025876.2¹ NP_080152.1¹ 154335380⁵
chicken (Gallus gallus)	Aves	CDK5RAP1¹	CDK5 regulatory subunit associated protein 1	76.49(n) 82.11(a)		419292 XM_417464.4 XP_417464.2
lizard (Anolis carolinensis)	Reptilia	CDK5RAP1⁶	CDK5 regulatory subunit associated protein 1	66(a)	1 ↔ 1	GL343886.1(26074-51372)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12738²	Xenopus laevis transcribed sequence with weak similarity more	78.63(n)		BJ073828.1
zebrafish (Danio rerio)	Actinopterygii	zgc:162738¹	zgc:162738	63.11(n) 68(a)		558659 NM_001110379.1 NP_001103849.1
fruit fly (Drosophila melanogaster)	Insecta	CG6345¹	CG6345	56.36(n) 55.87(a)		41271 NM_141745.4 NP_650002.1
worm (Caenorhabditis elegans)	Secernentea	F25B5.5¹	F25B5.5	55.08(n) 51.69(a)		175841 NM_065889.5 NP_498290.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G36390¹	AT4G36390	55.42(n) 53.33(a)		829791 NM_119802.2 NP_195357.2
rice (Oryza sativa)	Liliopsida	Os11g0592800¹	Os11g0592800	56.7(n) 53.64(a)		4350829 NM_001074728.1 NP_001068196.1

ENSEMBL Gene Tree for CDK5RAP1 (if available)
TreeFam Gene Tree for CDK5RAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CDK5RAP1 gene

CDKAL1²

CDK5RAP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13038201^1,2	C,F,H	--	31946260(+)	`GGGGGT/CTGTAA`	5	--	ds500¹		7		NS EA NA	616
rs187809289^1,2		--	31946272(+)	`GGAAAA/GCAGAG`	5	--	ds500¹		0	--	--	--	--
rs147584179^1,2	C	--	31946397(+)	`TGCAGC/TGATAG`	5	--	ds500¹		0	--	--	--	--
rs77540307^1,2	F	--	31946410(+)	`AGCTAA/TGTCAG`	5	--	ds500¹		1		EA	120
rs142092611^1,2	C	--	31946445(+)	`AGGTCA/GAGAGC`	5	--	ds500¹		0	--	--	--	--
rs17124640^1,2	C,F	--	31946537(+)	`GGGAGC/AAGTGT`	5	--	ds500¹		5		NA	144
rs116917900^1,2	F	--	31946620(+)	`AAAAAC/TGAAGT`	5	--	ds500¹		1		NA	120
rs138912660^1,2		--	31946630(+)	`TCAAAC/GTGAGA`	5	--	ds500¹		0	--	--	--	--
rs117988303^1,2	F	--	31946631(+)	`CAAAGT/GGAGAG`	5	--	ds500¹		1		EA	120
rs17124642^1,2	C,F,H	--	31946661(+)	`TTAGGT/AAAATT`	5	--	ut3¹ ese³		9		NA NS EA WA	658

HapMap Linkage Disequilibrium report for CDK5RAP1 (31946645 - 31989367 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CDK5RAP1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv819750	CNV	Loss	19587683

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608200 OMIM disorders: --

6 diseases for CDK5RAP1: About MalaCards

mikulicz disease narcolepsy vitiligo tuberculosis

neuronitis malaria

1 disease from the University of Copenhagen DISEASES database for CDK5RAP1:

Mikulicz disease

CDK5RAP1 for disorders About GeneDecksing

Genetic Association Database (GAD): CDK5RAP1
Human Genome Epidemiology (HuGE) Navigator: CDK5RAP1 (4 documents)

Export disorders for CDK5RAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDK5RAP1 gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with CDK5RAP1)

Utopia: connect your pdf to the dynamic
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Cloning of three novel neuronal Cdk5 activator binding proteins. (PubMed id 10721722)^{1, 2, 3, 9} Ching Y.-P.... Wang J.H. (Gene 2000)
Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PubMed id 15329498)^{1, 2, 3} Zou X.... Mao Y. (Genes Genet. Syst. 2004)
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PubMed id 11882646)^{1, 2, 3} Ching Y.-P.... Wang J.H. (J. Biol. Chem. 2002)
Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)^{1, 4} Eriksson N....Mountain J. (PLoS Genet. 2010)
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)^{1, 4} Shimada M....Tokunaga K. (Hum. Genet. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (Genome Res. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51654	HGNC: 15880	AceView: CDK5RAP1	Ensembl:ENSG00000101391	euGenes: HUgn51654
ECgene: CDK5RAP1	H-InvDB: CDK5RAP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDK5RAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDK5RAP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDK5RAP1 gene:
Search GeneIP for patents involving CDK5RAP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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CDK5RAP1 Gene

CDK5 Regulatory Subunit Associated Protein 1

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CDK5RAP1 Gene

CDK5 Regulatory Subunit Associated Protein 1

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