CDK5RAP1 Gene

Aliases
for CDK5RAP1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC20M031705 GC20M032615 GC20M032662 GC20M031410 GC20M028734

Summaries
for CDK5RAP1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for CDK5RAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000020.10  NC_018931.2  NT_011362.11  

SwitchGear Promoter luciferase reporter plasmid: CDK5RAP1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5RAP1

CDK5RAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M031946:  view genomic region     (about GC identifiers)

Proteins
for CDK5RAP1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for CDK5RAP1: NX_Q96SZ6

Explore proteomics data for CDK5RAP1 at MOPED

Post-translational modifications: 

CDK5RAP1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for CDK5RAP1 OriGene Custom MassSpec OriGene Custom Protein Services for CDK5RAP1
	GenScript Custom Purified and Recombinant Proteins Services for CDK5RAP1
	Novus Biologicals CDK5RAP1 Proteins Novus Biologicals CDK5RAP1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CDK5RAP1
	Search eBioscience for Proteins for CDK5RAP1
	Search GeneTex for Proteins for CDK5RAP1
	antibodies-online proteins for CDK5RAP1 (5 products)
	antibodies-online peptides for CDK5RAP1

CDK5RAP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CDK5RAP1
	Novus Biologicals CDK5RAP1 Antibodies
	Abcam antibodies for CDK5RAP1
	Cloud-Clone Corp. Antibodies for CDK5RAP1
	ThermoFisher Antibody for CDK5RAP1
	antibodies-online antibodies for CDK5RAP1 (33 products)

CDK5RAP1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CDK5RAP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDK5RAP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CDK5RAP1 Cloud-Clone Corp. CLIAs for CDK5RAP1
	Search eBioscience for ELISAs for CDK5RAP1
	antibodies-online kits for CDK5RAP1 (6 products)

Domains /
Families
for CDK5RAP1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q96SZ6

Find genes that share domains with CDK5RAP1           About GenesLikeMe

Function
for CDK5RAP1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

genOway: Develop your customized and physiologically relevant rodent model for CDK5RAP1

miRNA Products:		miRTarBase miRNAs that target CDK5RAP1: hsa-mir-16-5p (MIRT001473)
		Block miRNA regulation of human, mouse, rat CDK5RAP1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CDK5RAP1
		SwitchGear 3'UTR luciferase reporter plasmid: CDK5RAP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CDK5RAP1
		Predesigned siRNA for gene silencing in human, mouse, rat CDK5RAP1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CDK5RAP1

Clone Products:		OriGene clones in human, mouse for CDK5RAP1 (see all 12) OriGene ORF clones in mouse, rat for CDK5RAP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CDK5RAP1 (NM_016082)
		Sino Biological Human cDNA Clone for CDK5RAP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5RAP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5RAP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDK5RAP1
		Browse ESI BIO Cell Lines and PureStem Progenitors for CDK5RAP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5RAP1

Localization
for CDK5RAP1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	1
mitochondrion	1
nucleus	1

About this image

Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for CDK5RAP1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for CDK5RAP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for CDK5RAP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for CDK5RAP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDK5RAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGGTGGAGA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CDK5RAP1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK5RAP1
		QuantiTect SYBR Green Assays in human, mouse, rat CDK5RAP1
		QuantiFast Probe-based Assays in human, mouse, rat CDK5RAP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5RAP1

Orthologs
for CDK5RAP1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for CDK5RAP1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for CDK5RAP1 gene

CDKAL1²  

Find genes that share paralogs with CDK5RAP1           About GenesLikeMe

Genomic Variants
for CDK5RAP1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for CDK5RAP1 (see all 924)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs130382011,2	C,F,H	--	31946260(+)	GGGGGT/CTGTAA	5	--	ds5001		7		NS EA NA	616
rs1878092891,2		--	31946272(+)	GGAAAA/GCAGAG	5	--	ds5001		0	--	--	--	--
rs1475841791,2	C	--	31946397(+)	TGCAGC/TGATAG	5	--	ds5001		0	--	--	--	--
rs775403071,2	F	--	31946410(+)	AGCTAA/TGTCAG	5	--	ds5001		1		EA	120
rs1420926111,2	C	--	31946445(+)	AGGTCA/GAGAGC	5	--	ds5001		0	--	--	--	--
rs171246401,2	C,F	--	31946537(+)	GGGAGC/AAGTGT	5	--	ds5001		5		NA	144
rs1169179001,2	F	--	31946620(+)	AAAAAC/TGAAGT	5	--	ds5001		1		NA	120
rs1389126601,2		--	31946630(+)	TCAAAC/GTGAGA	5	--	ds5001		0	--	--	--	--
rs1179883031,2	F	--	31946631(+)	CAAAGT/GGAGAG	5	--	ds5001		1		EA	120
rs171246421,2	C,F,H	--	31946661(+)	TTAGGT/AAAATT	5	--	ut31 ese3		9		NA NS EA WA	658

HapMap Linkage Disequilibrium report for CDK5RAP1 (31946645 - 31989367 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CDK5RAP1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv819750	CNV	Loss	19587683

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CDK5RAP1

DNA2.0 Custom Variant and Variant Library Synthesis for CDK5RAP1

Disorders / Diseases
for CDK5RAP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for CDK5RAP1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDK5RAP1 gene, integrated from 10 sources (see all 25): (articles sorted by number of sources associating them with CDK5RAP1)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PubMed id 10721722)^{1, 2, 3, 9} Ching Y.-P.... Wang J.H. (Gene 2000)
2. Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PubMed id 15329498)^{1, 2, 3} Zou X.... Mao Y. (Genes Genet. Syst. 2004)
3. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PubMed id 11882646)^{1, 2, 3} Ching Y.-P.... Wang J.H. (J. Biol. Chem. 2002)
4. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)^{1, 4} Eriksson N....Mountain J. (PLoS Genet. 2010)
5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)^{1, 4} Shimada M....Tokunaga K. (Hum. Genet. 2010)
6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (Genome Res. 2000)

External Searches for CDK5RAP1 gene

Genome Databases showing CDK5RAP1 gene

Other Databases showing CDK5RAP1 gene

Specialized Databases showing CDK5RAP1 gene

Products
for CDK5RAP1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section