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Aliases for CDK5RAP1 Gene

Aliases for CDK5RAP1 Gene

  • CDK5 Regulatory Subunit Associated Protein 1 2 3 5
  • CDK5 Activator-Binding Protein C42 3 4
  • C20orf34 3 4
  • CDK5 Regulatory Subunit-Associated Protein 1 3
  • Chromosome 20 Open Reading Frame 34 2
  • HSPC167 3
  • CGI-05 3
  • C42 3

External Ids for CDK5RAP1 Gene

Previous HGNC Symbols for CDK5RAP1 Gene

  • C20orf34

Previous GeneCards Identifiers for CDK5RAP1 Gene

  • GC20M031705
  • GC20M032615
  • GC20M032662
  • GC20M031410
  • GC20M031946
  • GC20M028734

Summaries for CDK5RAP1 Gene

Entrez Gene Summary for CDK5RAP1 Gene

  • This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for CDK5RAP1 Gene

CDK5RAP1 (CDK5 Regulatory Subunit Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and transferase activity. An important paralog of this gene is CDKAL1.

UniProtKB/Swiss-Prot for CDK5RAP1 Gene

  • Specifically inhibits CDK5 activation by CDK5R1.

Gene Wiki entry for CDK5RAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5RAP1 Gene

Genomics for CDK5RAP1 Gene

Regulatory Elements for CDK5RAP1 Gene

Enhancers for CDK5RAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F032965 1.8 VISTA FANTOM5 Ensembl ENCODE 3.6 +428.7 428739 15.8 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 MAPRE1 ENSG00000260257 CCM2L ZNF341 CDK5RAP1 PIR55937 EFCAB8
GH20F033553 1.2 FANTOM5 Ensembl ENCODE 2.3 -153.0 -153042 3.1 HDGF PKNOX1 ATF1 MLX SIN3A ZNF48 YY1 ELK1 NFYC MIER2 CBFA2T2 C20orf144 ACTL10 NECAB3 PXMP4 ENSG00000229188 ZNF341 CDK5RAP1 CHMP4B BPIFB4
GH20F033400 0.4 ENCODE 0.8 +0.5 540 2.1 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 BPIFB5P RPL12P3 BPIFA3 ENSG00000224876 ENSG00000229188 SUN5 LOC105372596 RPS2P1 ENSG00000272945 ASIP
GH20F033408 1 Ensembl ENCODE 0.4 -7.3 -7322 1.3 ZFHX2 EGR2 SNTA1 CBFA2T2 ACTL10 NECAB3 C20orf144 CDK5RAP1 PIR51053
GH20F033407 0.2 ENCODE 0.4 -5.6 -5558 0.1 CTCF SUZ12 NRF1 REST SMARCA4 POLR2A PRDM10 EZH2 SNTA1 CBFA2T2 ACTL10 NECAB3 C20orf144 CDK5RAP1 PIR51053
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDK5RAP1 on UCSC Golden Path with GeneCards custom track

Promoters for CDK5RAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001836785 602 1801 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3

Genomic Location for CDK5RAP1 Gene

Chromosome:
20
Start:
33,358,839 bp from pter
End:
33,401,902 bp from pter
Size:
43,064 bases
Orientation:
Minus strand

Genomic View for CDK5RAP1 Gene

Genes around CDK5RAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5RAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5RAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5RAP1 Gene

Proteins for CDK5RAP1 Gene

  • Protein details for CDK5RAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ6-CK5P1_HUMAN
    Recommended name:
    CDK5 regulatory subunit-associated protein 1
    Protein Accession:
    Q96SZ6
    Secondary Accessions:
    • A8K7R0
    • Q5QP46
    • Q5QP47
    • Q5QP48
    • Q675N4
    • Q675N5
    • Q9BVG6
    • Q9BWZ5
    • Q9H859
    • Q9NZZ9
    • Q9Y3F0

    Protein attributes for CDK5RAP1 Gene

    Size:
    601 amino acids
    Molecular mass:
    67689 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.
    SequenceCaution:
    • Sequence=AAD34147.1; Type=Frameshift; Positions=3, 32, 128, 133, 569; Evidence={ECO:0000305}; Sequence=AAF29131.1; Type=Frameshift; Positions=213, 244, 267, 282; Evidence={ECO:0000305}; Sequence=BAB55120.1; Type=Erroneous termination; Positions=500; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK5RAP1 Gene

neXtProt entry for CDK5RAP1 Gene

Post-translational modifications for CDK5RAP1 Gene

  • Ubiquitination at Lys 70 and Lys 378
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CDK5RAP1

No data available for DME Specific Peptides for CDK5RAP1 Gene

Domains & Families for CDK5RAP1 Gene

Suggested Antigen Peptide Sequences for CDK5RAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SZ6

UniProtKB/Swiss-Prot:

CK5P1_HUMAN :
  • Contains 1 MTTase N-terminal domain.
  • Belongs to the methylthiotransferase family. MiaB subfamily.
Domain:
  • Contains 1 MTTase N-terminal domain.
  • Contains 1 TRAM domain.
Family:
  • Belongs to the methylthiotransferase family. MiaB subfamily.
genes like me logo Genes that share domains with CDK5RAP1: view

No data available for Gene Families for CDK5RAP1 Gene

Function for CDK5RAP1 Gene

Molecular function for CDK5RAP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically inhibits CDK5 activation by CDK5R1.

Gene Ontology (GO) - Molecular Function for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016740 transferase activity IEA --
GO:0019887 protein kinase regulator activity IBA --
GO:0019901 protein kinase binding NAS 10721722
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with CDK5RAP1: view
genes like me logo Genes that share phenotypes with CDK5RAP1: view

Animal Models for CDK5RAP1 Gene

MGI Knock Outs for CDK5RAP1:

Animal Model Products

miRNA for CDK5RAP1 Gene

miRTarBase miRNAs that target CDK5RAP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK5RAP1 Gene

Localization for CDK5RAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK5RAP1 Gene COMPARTMENTS Subcellular localization image for CDK5RAP1 gene
Compartment Confidence
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CDK5RAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK5RAP1 Gene

Pathways & Interactions for CDK5RAP1 Gene

SuperPathways for CDK5RAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK5RAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification IEA --
GO:0007420 brain development NAS 10915792
GO:0009451 RNA modification IEA --
GO:0035600 NOT tRNA methylthiolation IBA --
GO:0043412 macromolecule modification IEA --
genes like me logo Genes that share ontologies with CDK5RAP1: view

No data available for Pathways by source and SIGNOR curated interactions for CDK5RAP1 Gene

Drugs & Compounds for CDK5RAP1 Gene

(1) Drugs for CDK5RAP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with CDK5RAP1: view

Transcripts for CDK5RAP1 Gene

Unigene Clusters for CDK5RAP1 Gene

CDK5 regulatory subunit associated protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5RAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: -
SP16: - - - - - -
SP17: - - - - - - - - - - - -
SP18:
SP19: - - -
SP20: - - - -
SP21:

ExUns: 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK5RAP1 Gene

GeneLoc Exon Structure for
CDK5RAP1
ECgene alternative splicing isoforms for
CDK5RAP1

Expression for CDK5RAP1 Gene

mRNA expression in normal human tissues for CDK5RAP1 Gene

Protein differential expression in normal tissues from HIPED for CDK5RAP1 Gene

This gene is overexpressed in Cerebrospinal fluid (54.9) and Plasma (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK5RAP1 Gene



Protein tissue co-expression partners for CDK5RAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK5RAP1 Gene:

CDK5RAP1

SOURCE GeneReport for Unigene cluster for CDK5RAP1 Gene:

Hs.435952

mRNA Expression by UniProt/SwissProt for CDK5RAP1 Gene:

Q96SZ6-CK5P1_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CDK5RAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK5RAP1 Gene

Orthologs for CDK5RAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK5RAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK5RAP1 34 35
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia CDK5RAP1 34 35
  • 89.21 (n)
dog
(Canis familiaris)
Mammalia CDK5RAP1 34 35
  • 89 (n)
mouse
(Mus musculus)
Mammalia Cdk5rap1 34 16 35
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia Cdk5rap1 34
  • 85.91 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK5RAP1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK5RAP1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK5RAP1 34 35
  • 76.49 (n)
lizard
(Anolis carolinensis)
Reptilia CDK5RAP1 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5rap1 34
  • 67.99 (n)
Str.13196 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12738 34
zebrafish
(Danio rerio)
Actinopterygii zgc:162738 34
  • 63.11 (n)
CDK5RAP1 35
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.505 34
fruit fly
(Drosophila melanogaster)
Insecta CG6345 34 35
  • 56.36 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012104 34
  • 55.79 (n)
worm
(Caenorhabditis elegans)
Secernentea F25B5.5 34 35
  • 55.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G36390 34
  • 55.42 (n)
rice
(Oryza sativa)
Liliopsida Os11g0592800 34
  • 56.7 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.1217 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for CDK5RAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5RAP1 Gene

ENSEMBL:
Gene Tree for CDK5RAP1 (if available)
TreeFam:
Gene Tree for CDK5RAP1 (if available)

Paralogs for CDK5RAP1 Gene

Paralogs for CDK5RAP1 Gene

genes like me logo Genes that share paralogs with CDK5RAP1: view

Variants for CDK5RAP1 Gene

Sequence variations from dbSNP and Humsavar for CDK5RAP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111233392 -- 33,370,927(+) CCTCT(C/T)ACCAG intron-variant
rs111324130 -- 33,372,442(+) CTAAG(C/T)ACTTC intron-variant
rs111360441 -- 33,366,729(+) TGGGA(A/G)GCTGA intron-variant
rs111380665 -- 33,366,438(+) ACCCC(A/G)TCTCT intron-variant
rs111452943 -- 33,390,230(+) GATCA(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK5RAP1 Gene

Variant ID Type Subtype PubMed ID
nsv1064413 CNV gain 25217958
nsv819750 CNV loss 19587683

Variation tolerance for CDK5RAP1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK5RAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK5RAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5RAP1 Gene

Disorders for CDK5RAP1 Gene

Relevant External Links for CDK5RAP1

Genetic Association Database (GAD)
CDK5RAP1
Human Genome Epidemiology (HuGE) Navigator
CDK5RAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK5RAP1

No disorders were found for CDK5RAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK5RAP1 Gene

Publications for CDK5RAP1 Gene

  1. Cloning of three novel neuronal Cdk5 activator binding proteins. (PMID: 10721722) Ching Y.-P. … Wang J.H. (Gene 2000) 2 3 4 22 64
  2. Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1. (PMID: 15329498) Zou X. … Mao Y. (Genes Genet. Syst. 2004) 2 3 4 64
  3. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PMID: 11882646) Ching Y.-P. … Wang J.H. (J. Biol. Chem. 2002) 2 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64

Products for CDK5RAP1 Gene

Sources for CDK5RAP1 Gene

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