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Aliases for CDK5R2 Gene

Aliases for CDK5R2 Gene

  • Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39) 2 3 5
  • Cyclin-Dependent Kinase 5 Regulatory Subunit 2 3 4
  • Neuronal CDK5 Activator Isoform 2 3
  • CDK5 Activator 2 3 4
  • NCK5AI 3 4
  • P39I 3 4
  • P39 3 4
  • Cyclin-Dependent Kinase 5 Activator Isoform P39i 3
  • P39nck5ai 3

External Ids for CDK5R2 Gene

Previous GeneCards Identifiers for CDK5R2 Gene

  • GC02P217840
  • GC02P218545
  • GC02P219788
  • GC02P220026
  • GC02P219649
  • GC02P219532
  • GC02P211678
  • GC02P219824

Summaries for CDK5R2 Gene

Entrez Gene Summary for CDK5R2 Gene

  • The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK5R2 Gene

CDK5R2 (Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39)) is a Protein Coding gene. Diseases associated with CDK5R2 include Primary Microcephaly. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Neuroscience. GO annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of this gene is CDK5R1.

UniProtKB/Swiss-Prot for CDK5R2 Gene

  • Activator of CDK5/TPKII.

Gene Wiki entry for CDK5R2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5R2 Gene

Genomics for CDK5R2 Gene

Regulatory Elements for CDK5R2 Gene

Enhancers for CDK5R2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK5R2 on UCSC Golden Path with GeneCards custom track

Promoters for CDK5R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK5R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK5R2 Gene

218,959,628 bp from pter
218,962,162 bp from pter
2,535 bases
Plus strand

Genomic View for CDK5R2 Gene

Genes around CDK5R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5R2 Gene

Proteins for CDK5R2 Gene

  • Protein details for CDK5R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 5 activator 2
    Protein Accession:
    Secondary Accessions:
    • Q4ZFW6

    Protein attributes for CDK5R2 Gene

    367 amino acids
    Molecular mass:
    38705 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit and a regulatory subunit.

neXtProt entry for CDK5R2 Gene

Proteomics data for CDK5R2 Gene at MOPED

Post-translational modifications for CDK5R2 Gene

  • Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK5R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDK5R2 Gene

Domains & Families for CDK5R2 Gene

Protein Domains for CDK5R2 Gene

Suggested Antigen Peptide Sequences for CDK5R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin-dependent kinase 5 activator family.
  • Belongs to the cyclin-dependent kinase 5 activator family.
genes like me logo Genes that share domains with CDK5R2: view

No data available for Gene Families for CDK5R2 Gene

Function for CDK5R2 Gene

Molecular function for CDK5R2 Gene

UniProtKB/Swiss-Prot Function:
Activator of CDK5/TPKII.
genes like me logo Genes that share phenotypes with CDK5R2: view

Animal Models for CDK5R2 Gene

MGI Knock Outs for CDK5R2:

Animal Model Products

CRISPR Products

miRNA for CDK5R2 Gene

miRTarBase miRNAs that target CDK5R2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK5R2 Gene

Localization for CDK5R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5R2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for CDK5R2 Gene COMPARTMENTS Subcellular localization image for CDK5R2 gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK5R2: view

Pathways & Interactions for CDK5R2 Gene

genes like me logo Genes that share pathways with CDK5R2: view

Pathways by source for CDK5R2 Gene

1 GeneTex pathway for CDK5R2 Gene
1 Cell Signaling Technology pathway for CDK5R2 Gene
1 Qiagen pathway for CDK5R2 Gene

Gene Ontology (GO) - Biological Process for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7592934
GO:0001764 neuron migration IEA --
GO:0021549 cerebellum development IEA --
GO:0021722 superior olivary nucleus maturation IEA --
GO:0045860 positive regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CDK5R2: view

No data available for SIGNOR curated interactions for CDK5R2 Gene

Drugs & Compounds for CDK5R2 Gene

(10) Drugs for CDK5R2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AT7519 Investigational Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0
PHA-848125 Pharma CDK inhibitor,potent and ATP-competitive 0

(8) ApexBio Compounds for CDK5R2 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
Kenpaullone 142273-20-9
ML167 Clk4 inhibitor,highly selective 1285702-20-6
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
genes like me logo Genes that share compounds with CDK5R2: view

Transcripts for CDK5R2 Gene

mRNA/cDNA for CDK5R2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK5R2 Gene

Cyclin-dependent kinase 5, regulatory subunit 2 (p39):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5R2 Gene

No ASD Table

Relevant External Links for CDK5R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK5R2 Gene

mRNA expression in normal human tissues for CDK5R2 Gene

mRNA differential expression in normal tissues according to GTEx for CDK5R2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.1), Brain - Putamen (basal ganglia) (x5.5), Brain - Cortex (x5.5), Brain - Hippocampus (x4.3), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CDK5R2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK5R2 Gene

SOURCE GeneReport for Unigene cluster for CDK5R2 Gene Hs.158460

mRNA Expression by UniProt/SwissProt for CDK5R2 Gene

Tissue specificity: Brain and neuron specific.
genes like me logo Genes that share expression patterns with CDK5R2: view

Protein tissue co-expression partners for CDK5R2 Gene

- Elite partner

Primer Products

Orthologs for CDK5R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK5R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDK5R2 35
  • 94.37 (n)
  • 95.64 (a)
CDK5R2 36
  • 95 (a)
(Canis familiaris)
Mammalia CDK5R2 35
  • 93.01 (n)
  • 94.01 (a)
CDK5R2 36
  • 95 (a)
(Mus musculus)
Mammalia Cdk5r2 35
  • 91.19 (n)
  • 94.82 (a)
Cdk5r2 16
Cdk5r2 36
  • 95 (a)
(Pan troglodytes)
Mammalia CDK5R2 35
  • 99.36 (n)
  • 99.73 (a)
CDK5R2 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Cdk5r2 35
  • 91.28 (n)
  • 95.1 (a)
(Gallus gallus)
Aves CDK5R2 35
  • 76.59 (n)
  • 76.38 (a)
CDK5R2 36
  • 75 (a)
(Anolis carolinensis)
Reptilia CDK5R2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5r2 35
  • 65.39 (n)
  • 69.01 (a)
(Danio rerio)
Actinopterygii cdk5r2a 36
  • 63 (a)
cdk5r2b 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdk5alpha 37
  • 61 (a)
Cdk5alpha 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea T23F11.3 37
  • 51 (a)
cdka-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for CDK5R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5R2 Gene

Gene Tree for CDK5R2 (if available)
Gene Tree for CDK5R2 (if available)

Paralogs for CDK5R2 Gene

Paralogs for CDK5R2 Gene

(1) SIMAP similar genes for CDK5R2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDK5R2: view

Variants for CDK5R2 Gene

Sequence variations from dbSNP and Humsavar for CDK5R2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs359982 -- 218,962,212(-) TTCCA(C/T)TACCA downstream-variant-500B
rs359983 -- 218,958,775(-) GTGGA(C/T)GGAAG upstream-variant-2KB
rs1062027 -- 218,961,815(+) CGGCC(A/G)CGGCG utr-variant-3-prime
rs3841882 -- 218,961,964(+) GGGGG(-/G)TAGGC utr-variant-3-prime
rs6754801 -- 218,962,451(+) ACTTA(C/G)AGACC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CDK5R2 Gene

Variant ID Type Subtype PubMed ID
nsv834542 CNV Gain 17160897
nsv3169 CNV Loss 18451855

Variation tolerance for CDK5R2 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDK5R2 Gene

Disorders for CDK5R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK5R2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary microcephaly
  • microcephaly, primary
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDK5R2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDK5R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK5R2 Gene

Publications for CDK5R2 Gene

  1. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. (PMID: 7592934) Tang D. … Wang J.H. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. (PMID: 15917097) Rademakers R. … Cruts M. (Neurobiol. Aging 2005) 3 23
  3. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PMID: 10965112) Muravenko O.V. … Zelenin A.V. (Cytogenet. Cell Genet. 2000) 3 23
  4. The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. (PMID: 25128817) Tripathi B.K. … Zelenka P.S. (Exp. Cell Res. 2015) 3
  5. Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. (PMID: 24085300) Saito T. … Hisanaga S. (J. Biol. Chem. 2013) 3

Products for CDK5R2 Gene

Sources for CDK5R2 Gene