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CDK5R2 Gene

protein-coding   GIFtS: 54
GCID: GC02P219824

Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39)1 2     P392
NCK5AI2 3 5     Cyclin-Dependent Kinase 5 Activator 22
Neuronal CDK5 Activator Isoform1 2     Cyclin-Dependent Kinase 5 Activator Isoform P39i2
Cyclin-Dependent Kinase 5 Regulatory Subunit 22 3     p39nck5ai2
CDK5 Activator 22 3     p393
p39I2 3     

External Ids:    HGNC: 17761   Entrez Gene: 89412   Ensembl: ENSG000001714507   OMIM: 6037645   UniProtKB: Q133193   

Export aliases for CDK5R2 gene to outside databases

Previous GC identifers: GC02P217840 GC02P218545 GC02P219788 GC02P220026 GC02P219649 GC02P219532 GC02P211678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK5R2 Gene:
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an
active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to
cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDK5R2 Gene:
CDK5R2 (cyclin-dependent kinase 5, regulatory subunit 2 (p39)) is a protein-coding gene. GO annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of this gene is CDK5R1.

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Function: Activator of CDK5/TPKII

Gene Wiki entry for CDK5R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK5R2 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   Pax-5   SRF (504 AA)   E47   POU2F1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK5R2 promoter sequence
   Search Chromatin IP Primers for CDK5R2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5R2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219824:  view genomic region     (about GC identifiers)

Start:
219,824,377 bp from pter      End:
219,826,877 bp from pter
Size:
2,501 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5 activator 2 precursor  
Size: 367 amino acids; 38705 Da
Subunit: Heterodimer of a catalytic subunit and a regulatory subunit
Secondary accessions: Q4ZFW6

Explore the universe of human proteins at neXtProt for CDK5R2: NX_Q13319

Explore proteomics data for CDK5R2 at MOPED

Post-translational modifications: 

  • Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation
    signal is essential for the proper distribution of CDK5R2 (p39)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDK5R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003927.1  
    ENSEMBL proteins: 
     ENSP00000304250  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004944 CDK5_activator
     IPR013763 Cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q13319

    ProtoNet protein and cluster: Q13319

    1 Blocks protein domain: IPB004944 Cyclin-dependent kinase 5 activator

    UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Similarity: Belongs to the cyclin-dependent kinase 5 activator family


    Find genes that share domains with CDK5R2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD5R2_HUMAN, Q13319
    Function: Activator of CDK5/TPKII

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
    GO:0016534cyclin-dependent protein kinase 5 activator activity IEA--
         
    Find genes that share ontologies with CDK5R2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDK5R2:
     Paclitaxel antagonistic effect 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdk5r2):
     behavior/neurological  cellular  embryogenesis  growth/size/body  integument 
     mortality/aging  nervous system  normal 

    Find genes that share phenotypes with CDK5R2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdk5r2tm1Lht for CDK5R2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK5R2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDK5R2 (see all 15):
    hsa-miR-148b* hsa-miR-2114 hsa-miR-3917 hsa-miR-3065-3p hsa-miR-1271 hsa-miR-1324 hsa-miR-3175 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDK5R2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD5R2_HUMAN, Q13319: Cell membrane; Lipid-anchor; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    nucleus2
    cytosol1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016533cyclin-dependent protein kinase 5 holoenzyme complex IEA--

    Find genes that share ontologies with CDK5R2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK5R2 About    
    See pathways by source

    SuperPathContained pathways About
    1Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)
    2Neuroscience
    Neuroscience
    3Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development


    Find genes that share SuperPaths with CDK5R2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDK5R2
        Reelin Pathway (Cajal-Retzius cells)

    1 Cell Signaling Technology (CST) Pathway for CDK5R2
        Neuroscience

    1 BioSystems Pathway for CDK5R2
        Lissencephaly gene (LIS1) in neuronal migration and development


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK5R2
    Interactions:

        GeneGlobe Interaction Network for CDK5R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for CDK5R2 (Q133192, 3 ENSP000003042504) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    ACTN1P128143, ENSP000003779414I2D: score=2 STRING: ENSP00000377941
    CHN1P158822, ENSP000003867414MINT-62394 STRING: ENSP00000386741
    NDEL1ENSP000003339824STRING: ENSP00000333982
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS7592934
    GO:0001764neuron migration IEA--
    GO:0021549cerebellum development IEA--
    GO:0021722superior olivary nucleus maturation IEA--
    GO:0021766hippocampus development IEA--

    Find genes that share ontologies with CDK5R2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK5R2 (CD5R2)

    2 Novoseek inferred chemical compound relationships for CDK5R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 26.8 1 15123626 (1)
    serine 11.8 1 15123626 (1)



    Find genes that share compounds with CDK5R2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK5R2 gene: 
    NM_003936.4  

    Unigene Cluster for CDK5R2:

    Cyclin-dependent kinase 5, regulatory subunit 2 (p39)
    Hs.158460  [show with all ESTs]
    Unigene Representative Sequence: NM_003936
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302625(uc002vjf.3)
    miRNA
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    hsa-miR-148b* hsa-miR-2114 hsa-miR-3917 hsa-miR-3065-3p hsa-miR-1271 hsa-miR-1324 hsa-miR-3175 hsa-miR-3150a-3p
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    Additional mRNA sequence: 

    BC009910.2 BC041771.1 BT007437.1 U34051.1 

    1 DOTS entry:

    DT.437565 

    Selected AceView cDNA sequences (see all 54):

    BQ632773 U34051 BM054814 CA946805 AL534284 BM920695 BF969666 AI939360 
    CA776822 BI915232 AA323134 CR614750 BQ632483 CA777106 BM714651 BM893861 
    CA947078 CB156641 AI934461 BM967181 NM_003936 BT007437 AL538581 CK904676 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK5R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGAGCTG
    CDK5R2 Expression
    About this image


    CDK5R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Neural Tube (Nervous System)
             Mesencephalic Basal Plate
     
     Pancreas (Endocrine System)
    CDK5R2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK5R2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158460

    UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Tissue specificity: Brain and neuron specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDK5R2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk5r21 , 5 cyclin-dependent kinase 5, regulatory subunit 2 (p39)1, 5 91.19(n)1
    94.82(a)1
      1 (38.54 cM)5
    125701  NM_009872.31  NP_034002.21 
     748549345 
    chicken
    (Gallus gallus)
    Aves CDK5R21 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 76.59(n)
    76.38(a)
      100857507  XM_003641647.2  XP_003641695.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK5R26
    cyclin-dependent kinase 5, regulatory subunit 2 (p...
    76(a)
    1 ↔ 1
    1(87746714-87746953)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdk5r21 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 65.39(n)
    69.01(a)
      779711  NM_001078790.1  NP_001072258.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk5r2a6
    cdk5r2b6
    cyclin-dependent kinase 5, regulatory subunit 2b
    63(a)
    55(a)
    1 ↔ many
    1 ↔ many
    6(13653500-13655282) ENSDARG00000071011
    9(11808257-11810854) ENSDARG00000078671
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk5alpha3 protein amino acid phosphorylation
    cyclin-dependent more
    61(a)   31D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T23F11.33   -- 51(a)   III(4730960-4732968)   --


    ENSEMBL Gene Tree for CDK5R2 (if available)
    TreeFam Gene Tree for CDK5R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK5R2 gene
    CDK5R12  
    1 SIMAP similar gene for CDK5R2 using alignment to 2 protein entries:     CD5R2_HUMAN (see all proteins):
    CDK5R1

    Find genes that share paralogs with CDK5R2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK5R2 (see all 81)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825185801,2
    C--219822423(+) GCTGCG/TTAGAA 1 -- us2k10--------
    rs1156336941,2
    C,F--219822538(+) TTTCCG/ACCAGT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1169310431,2
    F--219822543(+) GCCAGT/GGCAAC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs770350651,2
    F--219822860(+) GCAGAC/ACACAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1117162221,2
    C--219822976(+) CAGTG-/ACACACA 1 -- us2k11Minor allele frequency- AC:0.50CSA 2
    rs610520261,2
    C--219822977(+) ACACA-/AC/CA 
            
    TATAT
    1 -- us2k10--------
    rs1379659091,2
    --219823033(+) TGGAGC/GTATGT 1 -- us2k10--------
    rs352462451,2
    C,F--219823076(+) AAGGGC/GAATCC 1 -- us2k15Minor allele frequency- G:0.00NS 188
    rs358334531,2
    C,F--219823084(+) TCCTTA/TGAATT 1 -- us2k15Minor allele frequency- T:0.00NS 188
    rs1866502391,2
    --219823352(+) AGAGAA/GAAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK5R2 (219824377 - 219826877 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDK5R2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3169CNV Loss18451855
    nsv834542CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603764    OMIM disorders: --


    Find genes that share disorders with CDK5R2           About GenesLikeMe

    2 Novoseek inferred disease relationships for CDK5R2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 30.8 1 15917097 (1)
    alzheimers disease 30.1 1 15917097 (1)


    Export disorders for CDK5R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK5R2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with CDK5R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. (PubMed id 7592934)1, 2, 3, 9 Tang D.... Wang J.H. (J. Biol. Chem. 1995)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. (PubMed id 15917097)1, 9 Rademakers R....Cruts M. (Neurobiol. Aging 2005)
    4. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PubMed id 10965112)1, 9 Muravenko O.V....Zelenin A.V. (Cytogenet. Cell Genet. 2000)
    5. Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. (PubMed id 24085300)1 Saito T....Hisanaga S. (J. Biol. Chem. 2013)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma. (PubMed id 20936377)1 Lu J.W....Hu R.M. (Med. Oncol. 2011)
    8. Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39. (PubMed id 20518484)1 Minegishi S....Hisanaga S. (Biochemistry 2010)
    9. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    10. Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. (PubMed id 18507738)2 Asada A.... Hisanaga S. (J. Neurochem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8941 HGNC: 1776 AceView: CDK5R2 Ensembl:ENSG00000171450 euGenes: HUgn8941
    ECgene: CDK5R2 H-InvDB: CDK5R2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK5R2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk5r2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK5R2 gene:
    Search GeneIP for patents involving CDK5R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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