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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK5R2 Gene

protein-coding   GIFtS: 56
GCID: GC02P219824

cyclin-dependent kinase 5, regulatory subunit 2 (p39)
 Explore 6 diseases affiliated with
CDK5R2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDK5R2    

Aliases
for CDK5R2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39)1 2     P39I1
NCK5AI1 2 3 5     Cyclin-Dependent Kinase 5 Activator 22
P391 2     Cyclin-Dependent Kinase 5 Activator Isoform P39i2
P39nck5ai1     Neuronal CDK5 Activator Isoform2
Cyclin-Dependent Kinase 5 Regulatory Subunit 22 3     P391 2
CDK5 Activator 22 3     

External Ids:    HGNC: 17761   Entrez Gene: 89412   Ensembl: ENSG000001714507   OMIM: 6037645   UniProtKB: Q133193   

Export aliases for CDK5R2 gene to outside databases

Previous GC identifers: GC02P217840 GC02P218545 GC02P219788 GC02P220026 GC02P219649 GC02P219532 GC02P211678


Summaries
for CDK5R2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK5R2:
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an
active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to
cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Function: Activator of CDK5/TPKII

Gene Wiki entry for CDK5R2


Genomic Views
for CDK5R2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK5R2 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   Pax-5   SRF (504 AA)   E47   POU2F1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK5R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK5R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5R2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219824:  view genomic region     (about GC identifiers)

Start:
 219,824,377 bp from pter      End:
 219,826,877 bp from pter
Size:
 2,501 bases      Orientation:
 plus strand

Proteins
for CDK5R2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5 activator 2 precursor  
Size: 367 amino acids; 38705 Da
Subunit: Heterodimer of a catalytic subunit and a regulatory subunit
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Secondary accessions: Q4ZFW6

Explore the universe of human proteins at neXtProt for CDK5R2: NX_Q13319

Post-translational modifications:

  • Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is
    • essential for the proper distribution of CDK5R2 (p39)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13319

    • CDK5R2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003927.1  
    ENSEMBL proteins: 
     ENSP00000304250  

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    Uscn Proteins for CDK5R2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016533cyclin-dependent protein kinase 5 holoenzyme complex IEA--


    CDK5R2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CDK5R2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK5R2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004944 CDK5_activator
     IPR013763 Cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q13319

    ProtoNet protein and cluster: Q13319

    1 Blocks protein family: IPB004944 Cyclin-dependent kinase 5 activator

    UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Similarity: Belongs to the cyclin-dependent kinase 5 activator family


    Function
    for CDK5R2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Function: Activator of CDK5/TPKII

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CDK5R2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
    GO:0016534cyclin-dependent protein kinase 5 activator activity IEA--


    CDK5R2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CDK5R2:
     Paclitaxel antagonistic effect 

    Animal Models:
         Mouse knock-out Cdk5r2tm1Lht for CDK5R2
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdk5r2):
     behavior/neurological  cellular  embryogenesis  growth/size  integument 
     mortality/aging  nervous system  normal 

    CDK5R2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDK5R2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2Reelin Pathway (Cajal-Retzius cells)
    		Reelin Pathway (Cajal-Retzius cells)1.00
    3Lissencephaly gene (LIS1) in neuronal migration and development
    		Lissencephaly gene (LIS1) in neuronal migration and development1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDK5R2
        Reelin Pathway (Cajal-Retzius cells)

    1 Cell Signaling Technology (CST) Pathway for CDK5R2
        Neuroscience

    1 BioSystems Pathway for CDK5R2 
        Lissencephaly gene (LIS1) in neuronal migration and development



    CDK5R2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK5R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for CDK5R2 (Q133192, 3 ENSP000003042504) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    ACTN1P128143, ENSP000003779414I2D: score=2 STRING: ENSP00000377941
    CHN1P158822, ENSP000003867414MINT-62394 STRING: ENSP00000386741
    NDEL1ENSP000003339824STRING: ENSP00000333982
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity TAS7592934
    GO:0001764neuron migration IEA--
    GO:0021549cerebellum development IEA--
    GO:0021722superior olivary nucleus maturation IEA--
    GO:0021766hippocampus development IEA--


    CDK5R2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK5R2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK5R2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDK5R2
    2 Novoseek chemical compound relationships for CDK5R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 26.8 1 15123626 (1)
    serine 11.8 1 15123626 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK5R2 / CD5R2 

    Transcripts
    for CDK5R2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK5R2 gene: 
    NM_003936.4  

    Unigene Cluster for CDK5R2:

    Cyclin-dependent kinase 5, regulatory subunit 2 (p39)
    Hs.158460  [show with all ESTs]
    Unigene Representative Sequence: NM_003936
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302625(uc002vjf.3)

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    hsa-miR-148b* hsa-miR-2114 hsa-miR-3917 hsa-miR-3065-3p hsa-miR-1271 hsa-miR-1324 hsa-miR-3175 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CDK5R2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK5R2 (see all 6)
    OriGene siRNA: CDK5R2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC009910.2 BC041771.1 BT007437.1 U34051.1 

    1 DOTS entry:

    DT.437565 

    24/54 AceView cDNA sequences (see all 54):

    BM920695 CA947078 AI939360 BM714651 AI934461 NM_003936 CA776822 BF969666 
    CR614750 BT007437 BM967181 BQ632483 AA323134 AL534284 CA946805 BQ632773 
    BI915232 BM054814 BM893861 CB156641 CA777106 U34051 BF515856 CK904676 

    GeneLoc Exon Structure


    Expression
    for CDK5R2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK5R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGGAGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK5R2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDK5R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK5R2

    SOURCE GeneReport for Unigene cluster: Hs.158460

    UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Tissue specificity: Brain and neuron specific

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    In Situ
    Assay Products:     
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    Orthologs
    for CDK5R2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CDK5R2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008575071 cyclin-dependent kinase 5 activator 2-like 78.43(n)
    79.29(a)    		   100857507  XM_003641647.1  XP_003641695.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK5R26
    		 --
    		 76(a)
    		 1 ↔ 1
    		 1(87746714-87746953)
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk5r2a6
    cdk5r2b6
    		 cyclin-dependent kinase 5, regulatory subunit 2b
    		 61(a)
    54(a)
    		 1 ↔ many
    1 ↔ many
    		 6(13653560-13655281)
    9(11808257-11810854)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdk5alpha3 protein amino acid phosphorylation
    cyclin-dependent more    		 61(a)   31D3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T23F11.33   -- 51(a)   III(4730960-4732968)   --


    ENSEMBL Gene Tree for CDK5R2 (if available)
    TreeFam Gene Tree for CDK5R2 (if available) 

    Paralogs
    for CDK5R2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK5R2 gene
    CDK5R12  
    1 SIMAP similar gene for CDK5R2 using alignment to 2 protein entries:     CD5R2_HUMAN (see all proteins):
    CDK5R1

    CDK5R2 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK5R2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/59 NCBI SNPs in CDK5R2 are shown (see all 59)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1825185801,2
    		--219822423(+) GCTGCG/TTAGAA 1 -- us2k10--------
    rs1156336941,2
    		F,--219822538(+) TTTCCG/ACCAGT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1169310431,2
    		F,--219822543(+) GCCAGT/GGCAAC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs770350651,2
    		F,--219822860(+) GCAGAC/ACACAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1117162221,2
    		C,--219822976(+) CAGTG-/ACACACA 1 -- us2k11Minor allele frequency- AC:0.50CSA 2
    rs610520261,2
    		C--219822991(+) ACACA-/CATATAT 1 -- us2k10--------
    rs1379659091,2
    		--219823033(+) TGGAGC/GTATGT 1 -- us2k10--------
    rs352462451,2
    		C,--219823076(+) AAGGGC/GAATCC 1 -- us2k15Minor allele frequency- G:0.00NS 188
    rs358334531,2
    		C,--219823084(+) TCCTTA/TGAATT 1 -- us2k15Minor allele frequency- T:0.00NS 188
    rs1866502391,2
    		--219823352(+) AGAGAA/GAAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK5R2 (219824377 - 219826877 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDK5R2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK5R2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5R2

    Disorders / Diseases
    for CDK5R2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK5R2 for disorders           About GeneDecksing

    OMIM gene information: 603764    OMIM disorders: --

    6 diseases for CDK5R2:    About MalaCards
    neuronitis    convulsions    alzheimer's disease    neurodegeneration
    microcephaly    cerebritis

    2 Novoseek disease relationships for CDK5R2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 30.8 1 15917097 (1)
    alzheimers disease 30.1 1 15917097 (1)


    Export disorders for CDK5R2 gene to outside databases

    Publications
    for CDK5R2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK5R2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CDK5R2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. (PubMed id 7592934)1, 2, 3, 9 Tang D.... Wang J.H. (1995)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. (PubMed id 15917097)1, 9 Rademakers R....Cruts M. (2005)
    4. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PubMed id 10965112)1, 9 Muravenko O.V....Zelenin A.V. (2000)
    5. Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma. (PubMed id 20936377)1 Lu J.W....Hu R.M. (2011)
    6. Membrane association facilitates degradation and clea vage of the cyclin-dependent kinase 5 activators p35 and p39. (PubMed id 20518484)1 Minegishi S....Hisanaga S. (2010)
    7. Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. (PubMed id 18507738)2 Asada A....Hisanaga S. (2008)
    8. Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. (PubMed id 12761178)1 Sakashita G....Kikuchi K. (2003)
    9. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. (PubMed id 11784720)1 Patzke H. and Tsai L.H. (2002)
    10. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. (PubMed id 12223541)1 Dhavan R....Tsai L.H. (2002)

    External Searches for CDK5R2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CDK5R2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8941 HGNC: 1776 AceView: CDK5R2 Ensembl:ENSG00000171450 euGenes: HUgn8941
    ECgene: CDK5R2 H-InvDB: CDK5R2

    Other Databases showing CDK5R2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK5R2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK5R2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk5r2/

    Intellectual Property
    for CDK5R2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK5R2 gene:
    Search GeneIP for patents involving CDK5R2

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