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CDK5R2 Gene

protein-coding   GIFtS: 59

GC02P219532
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
NCK5AI 1, 2, 3, 5
P39 1, 2, 3
P39I 3
p39nck5ai 1, 2
Descriptions
CDK5 activator 2 2, 3
Cyclin-dependent kinase 5 regulatory subunit 2 3
cyclin-dependent kinase 5 activator isoform p39i 2
cyclin-dependent kinase 5, regulatory subunit 2 2
cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2
neuronal CDK5 activator isoform 2
External Ids
HGNC: 17761
Entrez Gene: 89412
UniProtKB: Q133193
Ensembl: ENSG000001714507
Search outside databases for aliases for CDK5R2 gene

Previous GC identifers: GC02P217840 GC02P218545 GC02P219788 GC02P220026 GC02P219649

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CDK5R2:
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with
CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A
both share limited similarity to cyclins, and thus may define a distinct family of
cyclin-dependent kinase activating proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Function: Activator of CDK5/TPKII

Gene Wiki entry for CDK5R2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CDK5R2 gene  

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219532:     (about GC identifiers)

Start:
219,532,642 bp from pter
End:
219,535,121 bp from pter
Size:
2,480 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5 activator 2 precursor  
Size: 367 amino acids; 38705 Da
Subunit: Heterodimer of a catalytic subunit and a regulatory subunit
Secondary accessions: Q4ZFW6

REFSEQ proteins: NP_003927.1  

ENSEMBL proteins: 
ENSP00000304250 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (p39)
Human Recombinant Proteins from Abnova (CDK5R2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016533 cyclin-dependent protein kinase 5 activator complex IEA--
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Antibodies for CDK5R2: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of CDK5R2
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Cell Signaling Technology (CST) Antibodies for CDK5R2  (p39)
Antibodies from Abcam (p39), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (CDK5R2)
Novus Biologicals Antibodies for CDK5R2

Assays for CDK5R2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR004944 CDK5_activator
 IPR013763 Cyclin_related


   GeneDecks  CDK5R2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q13319

ProtoNet protein and cluster: Q13319

1 Blocks protein family: IPB004944 Cyclin-dependent kinase 5 activator

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Similarity: Belongs to the cyclin-dependent kinase 5 activator family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CDK5R2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003936

              Applied Biosystems Silencer® siRNAs for CDK5R2

              Sigma-Aldrich siRNA and siRNA Panels for CDK5R2  
                     Sigma-Aldrich shRNA for CDK5R2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for CDK5R2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003936
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003936
                                 untagged cDNA clones in CMV expression vector (see all 2): BC009910 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_003936

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Function: Activator of CDK5/TPKII

8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdk5r2):

behavior/neurologicalembryogenesisgrowth/sizelethality-prenatal/perinatallife span-post-weaning/aging
nervous systemnormaltouch/vibrissae

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016534 cyclin-dependent protein kinase 5 activator activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  CDK5R2 


3 Interacting proteins for CDK5R2 (ENSP000003042503 Q133192) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
CHN1P158822MINT-62394
CDK5ENSP000002975183STRING (score=.993)
NDEL1ENSP000002997343STRING (score=.899)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000079 regulation of cyclin-dependent protein kinase activity TAS7592934
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CDK5R2
1 Novoseek chemical compound relationship for CDK5R2 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
threonine 28.48 1 15123626 (1)
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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CDK5R2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003936

              Sigma-Aldrich siRNA and siRNA Panels for CDK5R2  
                     Sigma-Aldrich shRNA for CDK5R2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_003936  

REFSEQ mRNAs for CDK5R2 gene: 

NM_003936.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_003936  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003936
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003936
                                 untagged cDNA clones in CMV expression vector (see all 2): BC009910 

Additional cDNA sequence: 

BC009910.2 BC041771.1 BT007437.1 CR614750.1 U34051.1 

1 DOTS entry:

DT.437565 

24/54 AceView cDNA sequences (see all 54 ):

BM714651 CA947078 BF969666 BM893861 AI934461 BQ632483 CA776822 CR614750 
U34051 BM920695 AL534284 CA946805 BM967181 BI915232 AA323134 NM_003936 
BM054814 CB156641 AI939360 BQ632773 BT007437 CA777106 CK904676 AI279271 

highest scoring ESTs for CDK5R2:

AI689718 U34051 AA199665 AA323134 AI084857 AI279271 AI290951 AI302336 AI637466 AI885179 

Unigene Cluster for CDK5R2:

Cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Hs.158460  [show with all ESTs]
Unigene Representative Sequence: BC041771


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000302625  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CDK5R2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CDK5R2

1 / 2 / 3

4 probe-sets matching CDK5R2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
36361_at2, 3 U95-A 1 1.00 1.00 -0.40 1.20 U34051 1.00 1.00 1.00 1
60800_at2, 3 U95-C 1 1.00 1.00 0.99 0.89 AI689718 1.00 1.00 1.00 1

205852_at2, 3 U133-A 1 1.00 1.00 -- -- R51311 0.40 1.00 0.76 1

205852_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  CDK5R2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTGGGAGCTG

SOURCE GeneReport for Unigene cluster: Hs.158460

Expression variation in blood from EXPOLDB for CDK5R2

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Tissue specificity: Brain and neuron specific

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for CDK5R2 gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CDK5R21   -- cyclin-dependent kinase 5, regulatory subunit 2 (p39) 95(n)
96.46(a)
488529  XM_848027.1  XP_853120.1 
chimpanzee
(Pan troglodytes)
CDK5R21   -- cyclin-dependent kinase 5, regulatory subunit 2 (p39) 99.36(n)
99.73(a)
459953  XM_516099.2  XP_516099.2 
cow
(Bos taurus)
CDK5R21   -- cyclin-dependent kinase 5, regulatory subunit 2 (p39) 94.73(n)
96.73(a)
528533  XM_606959.3  XP_606959.3 
rat
(Rattus norvegicus)
Cdk5r21   -- cyclin-dependent kinase 5, regulatory subunit 2 (p39) 92.19(n)
96.19(a)
501164  XM_576588.2  XP_576588.2 
mouse
(Mus musculus)
Cdk5r21, 5 15
cyclin-dependent kinase 5, regulatory subunit 2 (p39)1, 5 91.73(n)1
95.64(a)1
125701  NM_009872.21  NP_034002.21 
 AF0163935  AK0808155  (see all 15)
About this table        Species with no ortholog for CDK5R2

ENSEMBL Gene Tree for CDK5R2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for CDK5R2 gene
CDK5R12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/25 NCBI SNPs in CDK5R2 are shown (see all 25 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 40)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs3599831,2
A,C,F,H,O219531741(-) GTGGAC/TGGAAG 1 -- ng5119Minor allele frequency- T:0.12EA NA EU WA NS 1108
--
rs67548011,2
A,C,F219535417(+) ACTTAG/CAGACC 1 -- ng315Minor allele frequency- C:0.08NS 190
--
rs10620271,2
C,F219534781(+) CGGCCG/ACGGCG 1 -- ut316Minor allele frequency- A:0.01MN NS 374
rs3599821,2
C,F219535178(-) TTCCAT/CTACCA 1 -- ng316Minor allele frequency- C:0.13MN NS 374
rs352014161,2
F219535005(+) GGGACT/GGAGTT 1 -- ut315Minor allele frequency- G:0.02NS 190
rs342480881,2
F219532178(+) CAGTGC/TAACGC 1 -- ng515Minor allele frequency- T:0.03NS 182
rs344307481,2
F219533905(+) GGGGCC/TGCGCC 1 -- ut315Minor allele frequency- T:0.03NS 172
rs361150381,2
F219533455(+) CTGCAG/AGGCTG 1 Q/Q syn15Minor allele frequency- A:0.01NS 180
rs342755151,2
F219532891(+) GAGGCG/CCTGGG 1 A/A syn15Minor allele frequency- C:0.01NS 180
rs352462451,2
--219531320(+) AAGGGC/GAATCC 1 -- ng515Minor allele frequency- G:0.00NS 188
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HapMap Linkage Disequilibrium images for CDK5R2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603764

2 Novoseek disease relationships for CDK5R2 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegeneration 33.45 1 15917097 (1)
alzheimers disease 32.40 1 15917097 (1)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/24 PubMed articles for CDK5R2 gene (see all 24 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8941 HGNC: 1776 AceView: CDK5R2 Ensembl:ENSG00000171450 euGenes: HUgn8941
ECgene: CDK5R2 H-InvDB: CDK5R2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk5r2/
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for CDK5R2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for CDK5R2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CDK5R2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Antibodies & Assays for CDK5R2  (p39)

 Recombinant Proteins
(p39)
 Antibodies (p39)
 Search OriGene for CDK5R2
 Search Tocris compounds for CDK5R2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for CDK5R2

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