 |
 | Services
| |
 |
Aliases & Descriptions for CDK5R2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| NCK5AI 1, 2, 3, 5 | | P39 1, 2, 3 | | P39I 3 | | p39nck5ai 1, 2 |
| | | Descriptions |
|---|
| CDK5 activator 2 2, 3 | | Cyclin-dependent kinase 5 regulatory subunit 2 3 | | cyclin-dependent kinase 5 activator isoform p39i 2 | | cyclin-dependent kinase 5, regulatory subunit 2 2 | | cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2 | | neuronal CDK5 activator isoform 2 |
|
| | Search outside databases for aliases for CDK5R2 genePrevious GC identifers: GC02P217840 GC02P218545 GC02P219788 GC02P220026 GC02P219649 |
Summaries for CDK5R2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CDK5R2: The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq] UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319Function: Activator of CDK5/TPKIIGene Wiki entry for CDK5R2 |
Genomic Location for CDK5R2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CDK5R2 gene 
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P219532:
(about GC identifiers)
Start:
|
219,532,642 bp from pter |
End:
|
219,535,121 bp from pter |
Size:
|
2,480 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for CDK5R2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319 (See
protein sequence)Recommended Name: Cyclin-dependent kinase 5 activator 2 precursor Size: 367 amino acids; 38705 Da
Subunit: Heterodimer of a catalytic subunit and a regulatory subunit
Secondary accessions: Q4ZFW6REFSEQ proteins: NP_003927.1
ENSEMBL proteins: ENSP00000304250
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016533 | cyclin-dependent protein kinase 5 activator complex |
IEA | -- | About this table
Antibodies for CDK5R2: Assays for CDK5R2: | Protein
Domains/ Families for CDK5R2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13319
ProtoNet protein and cluster: Q13319 1 Blocks protein family: IPB004944 Cyclin-dependent kinase 5 activator
UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319Similarity: Belongs to the cyclin-dependent kinase 5 activator family | Gene Function for CDK5R2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003936
Applied Biosystems Silencer® siRNAs for CDK5R2
Sigma-Aldrich siRNA and siRNA Panels for CDK5R2  Sigma-Aldrich shRNA for CDK5R2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003936                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003936                                  untagged cDNA clones in CMV expression vector (see all 2): BC009910 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003936
UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319Function: Activator of CDK5/TPKII8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cdk5r2):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016534 | cyclin-dependent protein kinase 5 activator activity |
IEA | -- | About this table | Pathways & Interactions for CDK5R2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for CDK5R2 
3 Interacting proteins for CDK5R2 (ENSP000003042503 Q133192) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000079 | regulation of cyclin-dependent protein kinase activity |
TAS | 7592934 | About this table
|
Drugs & Compounds for CDK5R2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CDK5R2 1 Novoseek chemical compound relationship for CDK5R2 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
28.48 |
1 |
15123626 (1) |
About this table
|
Transcripts for CDK5R2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003936
Sigma-Aldrich siRNA and siRNA Panels for CDK5R2  Sigma-Aldrich shRNA for CDK5R2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003936 REFSEQ mRNAs for CDK5R2 gene: NM_003936.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003936               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003936                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003936                                  untagged cDNA clones in CMV expression vector (see all 2): BC009910  Additional cDNA sequence: BC009910.2 BC041771.1 BT007437.1 CR614750.1 U34051.1 1 DOTS entry: DT.437565 24/54 AceView cDNA sequences (see all 54
):BM714651 CA947078 BF969666 BM893861 AI934461 BQ632483 CA776822 CR614750 U34051 BM920695 AL534284 CA946805 BM967181 BI915232 AA323134 NM_003936 BM054814 CB156641 AI939360 BQ632773 BT007437 CA777106 CK904676 AI279271
highest scoring ESTs for CDK5R2:AI689718 U34051 AA199665 AA323134 AI084857 AI279271 AI290951 AI302336 AI637466 AI885179 Unigene Cluster for CDK5R2: Cyclin-dependent kinase 5, regulatory subunit 2 (p39) Hs.158460 [show with all ESTs]Unigene Representative Sequence: BC041771
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000302625
|
Expression for CDK5R2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CDK5R2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CDK5R2
1 / 2 / 3 4 probe-sets matching CDK5R2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGGGAGCTG
SOURCE GeneReport for Unigene cluster: Hs.158460
Expression variation in blood from EXPOLDB for CDK5R2 UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319Tissue specificity: Brain and neuron specific |
Orthologs for CDK5R2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDK5R2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for CDK5R2
ENSEMBL Gene Tree for CDK5R2 | Paralogs for CDK5R2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CDK5R2 gene
- CDK5R12
|
SNPs/Variants for CDK5R2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CDK5R2 (up to first 250kb)
|
Disorders & Mutations for CDK5R2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603764
2 Novoseek disease relationships for CDK5R2 gene
About this table
|
Medical News for CDK5R2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CDK5R2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/24 PubMed articles for CDK5R2 gene (see all 24
): |
Search for CDK5R2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CDK5R2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CDK5R2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK5R2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/cdk5r2/ |
|
| | | About This Section
| --
| Services for CDK5R2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CDK5R2:

 | |
 | | | | |
|
 |  |  |
| Antibodies & Assays for CDK5R2  (p39) |
| | Recombinant Proteins (p39) | | Antibodies (p39) |
| | | Search Tocris compounds for CDK5R2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|