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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK5R2 Gene

protein-coding   GIFtS: 55
GCID: GC02P219824

Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39)1 2     P392
NCK5AI2 3 5     Cyclin-Dependent Kinase 5 Activator 22
Neuronal CDK5 Activator Isoform1 2     Cyclin-Dependent Kinase 5 Activator Isoform P39i2
Cyclin-Dependent Kinase 5 Regulatory Subunit 22 3     p39nck5ai2
CDK5 Activator 22 3     p393
p39I2 3     

External Ids:    HGNC: 17761   Entrez Gene: 89412   Ensembl: ENSG000001714507   OMIM: 6037645   UniProtKB: Q133193   

Export aliases for CDK5R2 gene to outside databases

Previous GC identifers: GC02P217840 GC02P218545 GC02P219788 GC02P220026 GC02P219649 GC02P219532 GC02P211678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK5R2 Gene:
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an
active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to
cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDK5R2 Gene: 
CDK5R2 (cyclin-dependent kinase 5, regulatory subunit 2 (p39)) is a protein-coding gene. Diseases associated with CDK5R2 include microcephaly, and lissencephaly. GO annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of this gene is CDK5R1.

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
Function: Activator of CDK5/TPKII

Gene Wiki entry for CDK5R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK5R2 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   Pax-5   SRF (504 AA)   E47   POU2F1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK5R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK5R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5R2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219824:  view genomic region     (about GC identifiers)

Start:
219,824,377 bp from pter      End:
219,826,877 bp from pter
Size:
2,501 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5 activator 2 precursor  
Size: 367 amino acids; 38705 Da
Subunit: Heterodimer of a catalytic subunit and a regulatory subunit
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Secondary accessions: Q4ZFW6

Explore the universe of human proteins at neXtProt for CDK5R2: NX_Q13319

Explore proteomics data for CDK5R2 at MOPED 

Post-translational modifications:

  • UniProtKB: Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation
    signal is essential for the proper distribution of CDK5R2 (p39)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13319

  • CDK5R2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK5R2 Protein Expression
    REFSEQ proteins: NP_003927.1  
    ENSEMBL proteins: 
     ENSP00000304250  

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    Cloud-Clone Corp. Proteins for CDK5R2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016533cyclin-dependent protein kinase 5 holoenzyme complex IEA--

    CDK5R2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004944 CDK5_activator
     IPR013763 Cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q13319

    ProtoNet protein and cluster: Q13319

    1 Blocks protein domain: IPB004944 Cyclin-dependent kinase 5 activator

    UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Similarity: Belongs to the cyclin-dependent kinase 5 activator family


    CDK5R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD5R2_HUMAN, Q13319
    Function: Activator of CDK5/TPKII

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
    GO:0016534cyclin-dependent protein kinase 5 activator activity IEA--
         
    CDK5R2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDK5R2:
     Paclitaxel antagonistic effect 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdk5r2):
     behavior/neurological  cellular  embryogenesis  growth/size  integument 
     mortality/aging  nervous system  normal 

    CDK5R2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk5r2tm1Lht for CDK5R2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK5R2 
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    SwitchGear 3'UTR luciferase reporter plasmidCDK5R2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5R2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK5R2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)
    2Neuroscience
    Neuroscience
    3Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDK5R2
        Reelin Pathway (Cajal-Retzius cells)

    1 Cell Signaling Technology (CST) Pathway for CDK5R2
        Neuroscience

    1 BioSystems Pathway for CDK5R2
        Lissencephaly gene (LIS1) in neuronal migration and development



    CDK5R2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK5R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for CDK5R2 (Q133192, 3 ENSP000003042504) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    ACTN1P128143, ENSP000003779414I2D: score=2 STRING: ENSP00000377941
    CHN1P158822, ENSP000003867414MINT-62394 STRING: ENSP00000386741
    NDEL1ENSP000003339824STRING: ENSP00000333982
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS7592934
    GO:0001764neuron migration IEA--
    GO:0021549cerebellum development IEA--
    GO:0021722superior olivary nucleus maturation IEA--
    GO:0021766hippocampus development IEA--

    CDK5R2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK5R2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK5R2 (CD5R2)

    2 Novoseek inferred chemical compound relationships for CDK5R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 26.8 1 15123626 (1)
    serine 11.8 1 15123626 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK5R2 / CD5R2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK5R2 gene: 
    NM_003936.4  

    Unigene Cluster for CDK5R2:

    Cyclin-dependent kinase 5, regulatory subunit 2 (p39)
    Hs.158460  [show with all ESTs]
    Unigene Representative Sequence: NM_003936
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302625(uc002vjf.3)

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    Additional mRNA sequence: 

    BC009910.2 BC041771.1 BT007437.1 U34051.1 

    1 DOTS entry:

    DT.437565 

    24/54 AceView cDNA sequences (see all 54):

    BI915232 CA946805 AI939360 NM_003936 BQ632483 CB156641 BM893861 CR614750 
    BQ632773 AL534284 BM714651 BM920695 BM054814 U34051 CA776822 BT007437 
    BM967181 AA323134 AI934461 CA777106 CA947078 BF969666 CK904676 BQ100785 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK5R2 expression in normal human tissues (normalized intensities)      CDK5R2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGAGCTG
    CDK5R2 Expression
    About this image


    CDK5R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Neural Tube (Nervous System)
             Mesencephalic Basal Plate
     
     Pancreas (Endocrine System)

    See CDK5R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK5R2

    SOURCE GeneReport for Unigene cluster: Hs.158460

    UniProtKB/Swiss-Prot: CD5R2_HUMAN, Q13319
    Tissue specificity: Brain and neuron specific

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDK5R2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk5r21 , 5 cyclin-dependent kinase 5, regulatory subunit 2 (p39)1, 5 91.73(n)1
    95.64(a)1
      1 (38.54 cM)5
    125701  NM_009872.31  NP_034002.21 
     748549345 
    chicken
    (Gallus gallus)
    Aves LOC1008575071 cyclin-dependent kinase 5 activator 2-like 78.43(n)
    79.29(a)
      100857507  XM_003641647.1  XP_003641695.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK5R26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    1(87746714-87746953)
    zebrafish
    (Danio rerio)
    Actinopterygii cdk5r2a6
    cdk5r2b6
    cyclin-dependent kinase 5, regulatory subunit 2b
    59(a)
    52(a)
    1 ↔ many
    1 ↔ many
    6(13653560-13655281)
    9(11808257-11810854)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk5alpha3 protein amino acid phosphorylation
    cyclin-dependent more
    61(a)   31D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T23F11.33   -- 51(a)   III(4730960-4732968)   --


    ENSEMBL Gene Tree for CDK5R2 (if available)
    TreeFam Gene Tree for CDK5R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK5R2 gene
    CDK5R12  
    1 SIMAP similar gene for CDK5R2 using alignment to 2 protein entries:     CD5R2_HUMAN (see all proteins):
    CDK5R1

    CDK5R2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/81 SNPs in CDK5R2 are shown (see all 81)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825185801,2
    C--219822423(+) GCTGCG/TTAGAA 1 -- us2k10--------
    rs1156336941,2
    C,F--219822538(+) TTTCCG/ACCAGT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1169310431,2
    F--219822543(+) GCCAGT/GGCAAC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs770350651,2
    F--219822860(+) GCAGAC/ACACAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1117162221,2
    C--219822976(+) CAGTG-/ACACACA 1 -- us2k11Minor allele frequency- AC:0.50CSA 2
    rs610520261,2
    C--219822977(+) ACACA-/AC/CA 
            
    TATAT
    1 -- us2k10--------
    rs1379659091,2
    --219823033(+) TGGAGC/GTATGT 1 -- us2k10--------
    rs352462451,2
    C,F--219823076(+) AAGGGC/GAATCC 1 -- us2k15Minor allele frequency- G:0.00NS 188
    rs358334531,2
    C,F--219823084(+) TCCTTA/TGAATT 1 -- us2k15Minor allele frequency- T:0.00NS 188
    rs1866502391,2
    --219823352(+) AGAGAA/GAAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK5R2 (219824377 - 219826877 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDK5R2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3169CNV Loss18451855
    nsv834542CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603764    OMIM disorders: --

    6 diseases for CDK5R2:    About MalaCards
    microcephaly    lissencephaly    neuronitis    alzheimer's disease
    cerebritis    hepatocellular carcinoma


    CDK5R2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for CDK5R2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 30.8 1 15917097 (1)
    alzheimers disease 30.1 1 15917097 (1)


    Export disorders for CDK5R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK5R2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with CDK5R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. (PubMed id 7592934)1, 2, 3, 9 Tang D.... Wang J.H. (1995)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. (PubMed id 15917097)1, 9 Rademakers R....Cruts M. (2005)
    4. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PubMed id 10965112)1, 9 Muravenko O.V....Zelenin A.V. (2000)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    6. Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma. (PubMed id 20936377)1 Lu J.W....Hu R.M. (2011)
    7. Membrane association facilitates degradation and clea vage of the cyclin-dependent kinase 5 activators p35 and p39. (PubMed id 20518484)1 Minegishi S....Hisanaga S. (2010)
    8. Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. (PubMed id 18507738)2 Asada A....Hisanaga S. (2008)
    9. Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. (PubMed id 12761178)1 Sakashita G....Kikuchi K. (2003)
    10. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. (PubMed id 11784720)1 Patzke H. and Tsai L.H. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8941 HGNC: 1776 AceView: CDK5R2 Ensembl:ENSG00000171450 euGenes: HUgn8941
    ECgene: CDK5R2 H-InvDB: CDK5R2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK5R2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk5r2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK5R2 gene:
    Search GeneIP for patents involving CDK5R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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