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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK5R1 Gene

protein-coding   GIFtS: 66
GCID: GC17P030813

cyclin-dependent kinase 5, regulatory subunit 1 (p35)
 Explore 26 diseases affiliated with
CDK5R1 via
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Biological research products
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Aliases
for CDK5R1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (P35)1 2     CDK5P352
P35nck5a1     Cyclin-Dependent Kinase 5 Activator 12
Cyclin-Dependent Kinase 5 Regulatory Subunit 12 3     Neuronal CDK5 Activator2
CDK5R2 3     P231
NCK5A2 3     P251
CDK5 Activator 12 3     P351
TPKII Regulatory Subunit2 3     Regulatory Partner For CDK5 Kinase2
Nck5a1     Tau Protein Kinase II 23kDa Subunit2

External Ids:    HGNC: 17751   Entrez Gene: 88512   Ensembl: ENSG000001767497   OMIM: 6034605   UniProtKB: Q150783   

Export aliases for CDK5R1 gene to outside databases

Previous GC identifers: GC17P030580 GC17P032848 GC17P030959 GC17P027838 GC17P027000


Summaries
for CDK5R1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK5R1:
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the
activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is
proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of
the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging
its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with
Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly
phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078
Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and
cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of
TPKII

Gene Wiki entry for CDK5R1


Genomic Views
for CDK5R1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK5R1 gene promoter:
         c-Fos   NF-1/L   NF-1   p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDK5R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK5R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q12

CDK5R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5R1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P030813:  view genomic region     (about GC identifiers)

Start:
 30,813,637 bp from pter      End:
 30,818,274 bp from pter
Size:
 4,638 bases      Orientation:
 plus strand

Proteins
for CDK5R1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5 activator 1 precursor  
Size: 307 amino acids; 34060 Da
Subunit: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular
complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows
kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity). Interacts
with RASGRF2
Subcellular location: Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side
(Probable). Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals
Subcellular location: Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The
conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear
regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from
neurites
Miscellaneous: Cleavage of p35 to p25 may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal
death in neurodegenerative diseases. The p25 form accumulates in neurons in the brain of patients with Alzheimer
disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application
of amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of
the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and
apoptosis
5 PDB 3D structures from and Proteopedia for CDK5R1:
1H4L (3D)        1UNG (3D)        1UNH (3D)        1UNL (3D)        3O0G (3D)    
Secondary accessions: E1P664 Q5U0G3

Explore the universe of human proteins at neXtProt for CDK5R1: NX_Q15078

Post-translational modifications:

  • The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter
    • half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an
    increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity)1
  • Myristoylated. A proper myristoylation signal is essential for the proper distribution of p351
  • Ubiquitinated. Degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5
    • phosphorylates p35 and induces its ubiquitination and subsequent degradation1
  • Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15078

    • CDK5R1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003876.1  
    ENSEMBL proteins: 
     ENSP00000318486   ENSP00000464129   ENSP00000463654  
    Reactome Protein details: Q15078
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    Uscn Proteins for CDK5R1

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density ISS--


    CDK5R1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CDK5R1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK5R1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004944 CDK5_activator
     IPR013763 Cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q15078

    ProtoNet protein and cluster: Q15078

    1 Blocks protein family: IPB004944 Cyclin-dependent kinase 5 activator

    UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078
    Similarity: Belongs to the cyclin-dependent kinase 5 activator family


    Function
    for CDK5R1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078
    Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and
    cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of
    TPKII

         Genatlas biochemistry entry for CDK5R1:
    cyclin-dependent kinase 5 regulatory subunit1,short lived molecule specifically expressed in neuronal
    cells,constitutively expressed after cleavage,associating and activating the CDK5 p25 complex with a resulting
    hyperphorylation of tau,which reduces tau's ability to associate with microtubules,and may be involved in the
    pathogenesis of neurodegenerative diseases

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    hsa-miR-607 hsa-miR-376b hsa-miR-15a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-3074-3p hsa-miR-10b* hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: CDK5R1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS7592934
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI15689152
    GO:0016301kinase activity ISS--


    CDK5R1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CDK5R1: Cdk5r1tm1Ohsh Cdk5r1tm1Lht Cdk5r1tm1Ivi
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdk5r1):
     behavior/neurological  cellular  embryogenesis  growth/size  integument 
     mortality/aging  nervous system 

    CDK5R1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDK5R1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoskeleton remodeling_Neurofilaments0.91
    3Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    		Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    		Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Alzheimer's disease0.43
    		Alzheimers Disease0.00
    5Development HGF signaling pathway
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.24

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for CDK5R1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Cytoskeleton remodeling Neurofilaments

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK5R1
        Rac1 Pathway
    THC Differentiation Pathway
    Reelin Pathway (Cajal-Retzius cells)
    Alzheimers Disease Pathway
    CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for CDK5R1
        Neuroscience

    3 GeneGo (Thomson Reuters) Pathways for CDK5R1
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Cytoskeleton remodeling Neurofilaments
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/6 BioSystems Pathways for CDK5R1 (see all 6) 
        Alzheimers Disease
    IL-6 Signaling Pathway
    Lissencephaly gene (LIS1) in neuronal migration and development
    Glucocorticoid receptor regulatory network
    Reelin signaling pathway

    4        Reactome Pathways for CDK5R1
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for CDK5R1):
        Alzheimer's disease


    CDK5R1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK5R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for CDK5R1 (Q150781, 3 ENSP000003184864) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5Q005351, 3, ENSP000002975184EBI-746189,EBI-1041567 I2D: score=11 STRING: ENSP00000297518
    AATKQ6ZMQ8-11, ENSP000003241964EBI-746189,EBI-2008436 I2D: score=1 STRING: ENSP00000324196
    SETQ011053, ENSP000003617774I2D: score=3 STRING: ENSP00000361777
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=2 STRING: ENSP00000381412
    CAPN1P073843, ENSP000002792474I2D: score=2 STRING: ENSP00000279247
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity TAS7592934
    GO:0001764neuron migration ISS--
    GO:0006468protein phosphorylation ----
    GO:0007049cell cycle ----
    GO:0007158neuron cell-cell adhesion ISS--


    CDK5R1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK5R1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK5R1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDK5R1

    2 DrugBank Compounds for CDK5R1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE-- --target--10592235
    Indirubin-3'-Monoxime-- --target--10592235

    10/13 Novoseek chemical compound relationships for CDK5R1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 87.3 4 9727024 (1), 14976144 (1), 15741232 (1)
    olomoucine 64.7 1 11743029 (1)
    glycogen 40.2 7 9565682 (2), 15322121 (1), 8787836 (1), 18242949 (1)
    threonine 37.4 3 20097924 (1), 15123626 (1), 12230554 (1)
    serine 22.3 3 20097924 (1), 15123626 (1), 12230554 (1)
    1,25 dihydroxy vitamin d3 17.9 8 15289351 (4)
    retinoic acid 10.6 2 11389014 (1), 15485494 (1)
    pd 98,059 9.36 3 15695523 (1), 15485494 (1)
    oligonucleotide 0 2 9822744 (1), 11743029 (1)
    glucose 0 4 14976144 (2), 16887799 (1), 19944742 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK5R1 / CD5R1 

    Transcripts
    for CDK5R1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section
    REFSEQ mRNAs for CDK5R1 gene: 
    NM_003885.2  

    Unigene Cluster for CDK5R1:

    Cyclin-dependent kinase 5, regulatory subunit 1 (p35)
    Hs.500015  [show with all ESTs]
    Unigene Representative Sequence: BC030792
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313401(uc002hhn.3) ENST00000584792 ENST00000584716(uc010ctc.3)


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    hsa-miR-607 hsa-miR-376b hsa-miR-15a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-3074-3p hsa-miR-10b* hsa-miR-629*
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK095754.1 BC020580.2 BC026347.1 BC030792.1 BC032081.1 BC035448.1 BT019573.1 X80343.1 

    5 DOTS entries:

    DT.450080  DT.120908893  DT.100653625  DT.92421890  DT.120908882 

    24/126 AceView cDNA sequences (see all 126):

    BC020580 BU734025 AV726218 BU844800 CR605929 NM_003885 F02507 BE892465 
    BC035448 BC032081 AL134197 BI870001 BM679531 BU552974 BM693572 BP377593 
    M85817 BE351035 T05015 AA885400 Z39335 T06956 CA776250 BF508764 

    GeneLoc Exon Structure


    Expression
    for CDK5R1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK5R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCTCAGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK5R1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDK5R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK5R1

    SOURCE GeneReport for Unigene cluster: Hs.500015

    UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078
    Tissue specificity: Brain and neuron specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK5R1: 
              Neurogenesis in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              GABA & Glutamate in human mouse rat

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    Orthologs
    for CDK5R1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CDK5R1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdk5r11 , 5 cyclin-dependent kinase 5, regulatory subunit 1 (p35)1, 5 92.51(n)1
    98.37(a)1    		   11 (47.94 cM)5
    125691  NM_009871.21  NP_034001.11 
     804770235 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK5R16
    		 --
    		 57(a)
    		 1 ↔ 1
    		 GL344418.1(19462-20448)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cdk5r1-A-prov2 cyclin-dependent kinase 5 regulatory subunit 75.6(n)    AF000951.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk5r1b1 cyclin-dependent kinase 5, regulatory subunit 1b (p35) 76.74(n)
    82.06(a)    		   436788  NM_001002515.1  NP_001002515.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdk5alpha3 protein amino acid phosphorylation
    cyclin-dependent more    		 51(a)   31D3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T23F11.33   -- 53(a)   III(4730960-4732968)   --


    ENSEMBL Gene Tree for CDK5R1 (if available)
    TreeFam Gene Tree for CDK5R1 (if available) 

    Paralogs
    for CDK5R1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK5R1 gene
    CDK5R22  
    1 SIMAP similar gene for CDK5R1 using alignment to 4 protein entries:     CD5R1_HUMAN (see all proteins):
    CDK5R2

    CDK5R1 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK5R1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/92 NCBI SNPs in CDK5R1 are shown (see all 92)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1902993951,2
    		--30812131(+) CTGCAA/GCCTCT 1 -- us2k10--------
    rs1932755911,2
    		--30812160(+) ATTCTC/TCTGCC 1 -- us2k10--------
    rs80724741,2
    		C,--30812163(+) ctcctA/Gcctca 1 -- us2k10--------
    rs1850085391,2
    		--30812207(+) CACCAC/TGCCTG 1 -- us2k10--------
    rs1890828101,2
    		--30812317(+) CCAAAA/GTACTG 1 -- us2k10--------
    rs124530951,2
    		H--30812407(+) TTGAAA/GAGCAG 1 -- us2k10--------
    rs728130421,2
    		C,F,--30812667(+) GCACCA/GTTTTG 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1817462991,2
    		--30812815(+) TAATCC/TGGATT 1 -- us2k10--------
    rs7567851,2
    		C,F,H,--30812845(-) CTGGGA/GAACAG 1 -- us2k130Minor allele frequency- G:0.49NA EA NS WA CSA 2484
    rs1458273261,2
    		--30812909(+) ACAACA/GGCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK5R1 (30813637 - 30818274 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CDK5R1
         1 CNV: 72866
    Human Gene Mutation Database (HGMD): CDK5R1

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    Disorders / Diseases
    for CDK5R1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK5R1 for disorders           About GeneDecksing

    OMIM gene information: 603460    OMIM disorders: --

    20/26 diseases for CDK5R1 (see all 26):    About MalaCards
    alzheimer's disease    neuronitis    amyotrophic lateral sclerosis    toxic encephalopathy
    lateral sclerosis    neurodegenerative disease    ganglioglioma    parkinson's disease
    tauopathy    convulsions    ischemia    neurodegeneration
    huntington's disease    retinoblastoma    breast cancer    cerebritis
    seizures    astrocytoma    lung cancer    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for CDK5R1:
    Alzheimer's disease     Toxic encephalopathy

    10/14 Novoseek disease relationships for CDK5R1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 61.4 1 11932941 (1)
    neurodegeneration 59.3 8 15978013 (2), 10604467 (1), 16932754 (1), 12478466 (1) (see all 5)
    alzheimers disease 58 24 10830966 (2), 15978013 (2), 12887424 (1), 19154537 (1) (see all 13)
    neurodegenerative diseases 49.8 8 15307952 (1), 10604467 (1), 14673209 (1), 18053171 (1) (see all 6)
    memory impairment 22.7 5 12887424 (1), 15978013 (1), 19118186 (1)
    neurological disorders 0.987 1 15307952 (1)
    retinoblastoma 0.651 1 15741232 (1)
    leukemia 0 2 15289351 (1)
    ischemia 0 2 12684463 (1)
    necrosis 0 1 15307952 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDK5R1 (9 documents)

    Export disorders for CDK5R1 gene to outside databases

    Publications
    for CDK5R1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK5R1 gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with CDK5R1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. (PubMed id 8090221)1, 2, 3 Tsai L.-H.... Harlow E. (1994)
    2. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. (PubMed id 10604467)1, 2, 9 Patrick G.N....Tsai L.H. (1999)
    3. Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. (PubMed id 17121855)1, 2 Kamei H....Hisanaga S. (2007)
    4. Mechanism of CDK5/p25 binding by CDK inhibitors. (PubMed id 15689152)1, 2 Mapelli M....Musacchio A. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Neurotoxicity induces cleavage of p35 to p25 by calpain. (PubMed id 10830966)1, 9 Lee M.S....Tsai L.H. (2000)
    7. Quantitative measurement of in vivo phosphorylation s tates of Cdk5 activator p35 by Phos-tag SDS-PAGE. (PubMed id 20097924)1, 9 Hosokawa T....Hisanaga S. (2010)
    8. The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability. (PubMed id 18053171)1, 9 Moncini S....Riva P. (2007)
    9. Identification of nuclear import mechanisms for the neuronal Cdk5 activator. (PubMed id 17060323)1, 9 Fu X....Qi R.Z. (2006)
    10. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PubMed id 16425041)1, 9 Venturin M....Riva P. (2006)

    External Searches for CDK5R1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK5R1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8851 HGNC: 1775 AceView: CDK5R1 Ensembl:ENSG00000176749 euGenes: HUgn8851
    ECgene: CDK5R1 Kegg: 8851 H-InvDB: CDK5R1

    Other Databases showing CDK5R1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK5R1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK5R1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK5R1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk5r1/

    Intellectual Property
    for CDK5R1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK5R1 gene:
    Search GeneIP for patents involving CDK5R1

    GeneCards and IP:
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