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CDK5R1 Gene

protein-coding GIFtS: 66

GC17P027838

cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDK5P35 ^²
CDK5R ^², ³
MGC33831 ^²
NCK5A ^², ³
Nck5a ^¹
p23 ^², ³
p25 ^²
p35 ^²
p35nck5a ^¹, ²

Descriptions
CDK5 activator 1 ^², ³
Cyclin-dependent kinase 5 regulatory subunit 1 ^³
TPKII regulatory subunit ^², ³
Tau protein kinase II 23 kDa subunit ^³
cyclin-dependent kinase 5 activator 1 ^²
cyclin-dependent kinase 5, regulatory subunit 1 ^²
cyclin-dependent kinase 5, regulatory subunit 1 (p35) ^²
neuronal CDK5 activator ^²
regulatory partner for CDK5 kinase ^²
tau protein kinase II 23kDa subunit ^²

External Ids
HGNC: 1775¹
Entrez Gene: 8851²
UniProtKB: Q15078³
Ensembl: ENSG00000176749⁷

Search outside databases for aliases for CDK5R1 gene

Previous GC identifers: GC17P030580 GC17P032848 GC17P030959

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDK5R1:

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5

(CDK5); the activation of CDK5 is required for proper development of the central nervous system.

The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The

cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to

nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and

changing its cellular location. The p25 form accumulates in the brain neurons of patients with

Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity,

and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which

contributes to Alzheimer's disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078

Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite

outgrowth and cortical lamination. Activator of TPKII

Gene Wiki entry for CDK5R1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDK5R1 gene

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q12

CDK5R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P027838: (about GC identifiers)

Start:	27,838,214 bp from pter
End:	27,842,384 bp from pter
Size:	4,171 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 5 activator 1 precursor

Size: 307 amino acids; 34060 Da

Subunit: Heterodimer composed of CDK5 and CDK5R (p25) and macromolecular complex composed of at

least CDK5, CDK5R (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase

activity (By similarity). Interacts with RASGRF2

Subcellular location: Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor;

Cytoplasmic side (Probable). Note=In the primary cortical neurons, p35 is present in the

peripheries and nerve terminals

Subcellular location: Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear

region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the

cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily

concentrated in the cell soma and is largely absent from neurites

PDB structures from and Proteopedia :

1H4L (3D)

1UNG (3D)

1UNH (3D)

1UNL (3D)

Post-translational modifications:

The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10

fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase:

p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the

p35/CDK5 kinase in vivo (By similarity)¹

Probably myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a

proper myristoylation signal is essential for the proper distribution of p35¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003876.1

ENSEMBL proteins:

ENSP00000318486

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CDK5R1
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CDK5R1
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDK5R1
	Recombinant Proteins from Abcam (p35 + p25, p35)
	Human Recombinant Proteins from Abnova (CDK5R1)

OriGene Purified Recombinant Human Protein: CDK5R1

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005886	plasma membrane	IEA	--
GO:0016533	cyclin-dependent protein kinase 5 activator complex	IEA	--
GO:0030424	axon	ISS	--

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Antibodies for CDK5R1:

	Invitrogen Antibodies for CDK5R1
	Millipore Mono- and Polyclonal Antibodies for the study of CDK5R1
	Sigma-Aldrich Antibody Arrays and Antibodies for CDK5R1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDK5R1 (p35)
	Antibodies from Abcam (p35 + p25, p35), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDK5R1)
	Novus Biologicals Antibodies for CDK5R1

Assays for CDK5R1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15078

ProtoNet protein and cluster: Q15078

1 Blocks protein family: IPB004944 Cyclin-dependent kinase 5 activator

UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078

Similarity: Belongs to the cyclin-dependent kinase 5 activator family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK5R1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDK5R1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003885

Applied Biosystems Silencer® siRNAs for CDK5R1

Sigma-Aldrich siRNA and siRNA Panels for CDK5R1

Sigma-Aldrich shRNA Panels and shRNA for CDK5R1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDK5R1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003885
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003885
untagged cDNA clones in CMV expression vector (see all 2): BC035448

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003885

UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078

Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite

outgrowth and cortical lamination. Activator of TPKII

Genatlas biochemistry entry for CDK5R1:

cyclin-dependent kinase 5 regulatory subunit1,short lived molecule specifically expressed in

neuronal cells,constitutively expressed after cleavage,associating and activating the CDK5 p25

complex with a resulting hyperphorylation of tau,which reduces tau's ability to associate with

microtubules,and may be involved in the pathogenesis of neurodegenerative diseases

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdk5r1):

behavior/neurological	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
life span-post-weaning/aging	nervous system	touch/vibrissae

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	7592934
GO:0005509	calcium ion binding	ISS	--
GO:0005515	protein binding	ISS	--
GO:0016534	cyclin-dependent protein kinase 5 activator activity	IEA	--
GO:0045296	cadherin binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for CDK5R1 (Your Favorite Gene powered by Ingenuity)

Amyloid Processing
Reelin Signaling in Neurons
Neuregulin Signaling
Huntington's Disease Signaling
CDK5 Signaling

GeneDecks CDK5R1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CDK5R1

5/18 Interacting proteins for CDK5R1 (ENSP00000318486³ Q15078¹) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AATK	Q6ZMQ8-1¹	EBI-746189, EBI-2008436
CDK5	ENSP00000297518³	STRING (score=.999)
PAK1	ENSP00000278568³	STRING (score=.96)
EGR1	ENSP00000239938³	STRING (score=.94)
CDK5RAP3	ENSP00000344683³	STRING (score=.939)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	7592934
GO:0001764	neuron migration	ISS	--
GO:0007158	neuron adhesion	ISS	--
GO:0007213	muscarinic acetylcholine receptor signaling pathway	ISS	--
GO:0007411	axon guidance	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CDK5R1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CDK5R1
7 Novoseek chemical compound relationships for CDK5R1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	36.24	2	15123626 (1), 12230554 (1)
glycogen	36.11	7	9565682 (2), 15322121 (1), 8787836 (1), 18242949 (1)
1,25 dihydroxy vitamin d3	19.90	8	15289351 (4)
pd 98,059	12.06	3	15695523 (1), 15485494 (1)
glucose	5.28	3	14976144 (2), 16887799 (1)
oligonucleotide	0.00	2	9822744 (1), 11743029 (1)
calcium	0.00	9	10830966 (3), 18242949 (1), 18289510 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK5R1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDK5R1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003885

Sigma-Aldrich siRNA and siRNA Panels for CDK5R1

Sigma-Aldrich shRNA Panels and shRNA for CDK5R1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003885

REFSEQ mRNAs for CDK5R1 gene:

NM_003885.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003885

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003885
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003885
                                 untagged cDNA clones in CMV expression vector (see all 2): BC035448

Additional cDNA sequence:

AK095754.1 BC020580.2 BC026347.1 BC030792.1 BC032081.1 BC035448.1 BT019573.1 CR605929.1

X80343.1

5 DOTS entries:

DT.450080 DT.120908893 DT.100653625 DT.92421890 DT.120908882

24/126 AceView cDNA sequences (see all 126 ):

T05015 BM668892 BU552974 BE351035 Z39335 BF508764 CR605929 BU579648

T06956 NM_003885 CA776250 BC032081 AV726218 BU734025 AW088233 BP377593

BM693572 BI870001 BM665391 BU844800 M85817 BX508001 AA885400 BC020580

highest scoring ESTs for CDK5R1:

X80343 AA338876 AA339551 AA460466 AA463407 AA987933 AA994463 AI003191 AI425035 AK095754

Unigene Cluster for CDK5R1:

Cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Hs.500015 [show with all ESTs]

Unigene Representative Sequence: BC030792

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000313401

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CDK5R1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDK5R1

¹ / ² / ³

8 probe-sets matching CDK5R1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36273_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.47	X80343	1.00	1.00	1.00	1
55644_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.02	R49183	0.60	1.00	0.82	1
799_at²^{, 3}	U95-A	1	1.00	1.00	0.17	1.60	X80343	1.00	1.00	1.00	1
800_g_at²^{, 3}	U95-A	2	1.00	0.91	0.56	1.08	X80343	1.00	1.00	1.00	1
204996_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003885	0.60	1.00	0.82	1
204995_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL567411	0.80	1.00	0.91	1
204996_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204995_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDK5R1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGCTCAGTT

SOURCE GeneReport for Unigene cluster: Hs.500015
Expression variation in blood from EXPOLDB for CDK5R1
UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078
Tissue specificity: Brain and neuron specific

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDK5R1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDK5R1¹	--	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	95.33(n) 99.02(a)	491154 XM_548274.2 XP_548274.1
chimpanzee (Pan troglodytes)	CDK5R1¹	--	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	100(n) 100(a)	747897 XM_001158783.1 XP_001158783.1
cow (Bos taurus)	CDK5R1¹	--	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	95.01(n) 99.35(a)	282173 NM_174512.2 NP_776937.1
rat (Rattus norvegicus)	Cdk5r1¹	--	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	92.51(n) 98.37(a)	116671 NM_053891.1 NP_446343.1
mouse (Mus musculus)	Cdk5r1^{1, 5}	11 (46.50 cM)⁵	cyclin-dependent kinase 5, regulatory subunit 1 (p35)^{1, 5}	92.51(n)¹ 98.37(a)¹	12569¹ NM_009871.2¹ NP_034001.1¹ AF121847⁵ AK039999⁵ (see all 26)

About this table Species with no ortholog for CDK5R1

ENSEMBL Gene Tree for CDK5R1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CDK5R1 gene

CDK5R2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/38 NCBI SNPs in CDK5R1 are shown (see all 38 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs731880^1,2	A,C,F,H	27842822(-)	`GCCCAT/AGTGGA`	1	--	ng3¹		12		EA NA EU WA	982
	rs756785^1,2	C,F,H	27836958(-)	`CTGGGA/GAACAG`	1	--	ng5¹		11		NA EA EU WA	802
	rs735555^1,2	C,F,H	27841563(-)	`GACACG/ACAACT`	1	--	ut3¹ ese³		14		NA MN EU EA WA NS	1542
	rs9333311^1,2	F,H	27842047(+)	`TTTGTT/CCCAAC`	1	--	ut3¹		5		NS EU EA WA	594
--	rs8192474^1,2	C,F	27839794(+)	`CCACAG/ATCTCT`	1	--	ut3¹ ese³		1		NS	180
--	rs9333297^1,2	F	27837983(+)	`GGAGCG/TTGGAC`	1	--	ng5¹		1		NS	130
--	rs9333309^1,2	H	27842022(+)	`TTCCAT/CGCAGT`	1	--	ut3¹		5		NS EU EA WA	582
--	rs4392115^1,2	C	27837597(+)	`ccccgA/Cggccg`	1	--	ng5¹		0	--	--	--	--
--	rs9333310^1,2	F	27842024(+)	`CCATGC/GAGTTA`	1	--	ut3¹		1		NS	174
	rs34511797^1,2	F	27839549(-)	`ATGAGG/ATTGAT`	1	N/N	syn¹		1		NA	78

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HapMap Linkage Disequilibrium images for CDK5R1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603460

UniProtKB/Swiss-Prot: CD5R1_HUMAN, Q15078

Cleavage of p35 to p25 may be involved in the pathogenesis of Alzheimer disease. The p25

form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal

brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of

amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical

neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal

disruption, morphological degeneration and apoptosis

10/14 Novoseek disease relationships for CDK5R1 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegeneration	61.82	8	15978013 (2), 10604467 (1), 16932754 (1), 12478466 (1) (see all 5)
neurofibrillary tangles	58.68	1	11932941 (1)
alzheimers disease	57.43	23	10830966 (2), 15978013 (2), 12887424 (1), 16413130 (1) (see all 12)
neurodegenerative diseases	47.35	7	15307952 (1), 10604467 (1), 14673209 (1), 18053171 (1) (see all 5)
memory impairment	25.65	5	12887424 (1), 15978013 (1), 19118186 (1)
neurological disorders	4.31	1	15307952 (1)
retinoblastoma	3.08	1	15741232 (1)
necrosis	0.00	1	15307952 (1)
breast cancer	0.00	2	17081516 (1)
tumors	0.00	2	15307952 (1), 11296485 (1)

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1 PharmGKB disease relationship for CDK5R1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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Human Gene Mutation Database: CDK5R1
Human Genome Epidemiology Navigator: CDK5R1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/164 PubMed articles for CDK5R1 gene (see all 164 ):

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. (PubMed id 8090221)^{2, 3, 4} Tsai L.-H.... Harlow E. (1994)
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. (PubMed id 10604467)^{1, 3, 4} Patrick G.N....Tsai L.H. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Neurotoxicity induces cleavage of p35 to p25 by calpain. (PubMed id 10830966)^{1, 3} Lee M.S....Tsai L.H. (2000)
The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability. (PubMed id 18053171)^{1, 3} Moncini S....Riva P. (2007)
Identification of nuclear import mechanisms for the neuronal Cdk5 activator. (PubMed id 17060323)^{1, 3} Fu X....Qi R.Z. (2006)
Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PubMed id 16425041)^{1, 3} Venturin M....Riva P. (2006)
Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. (PubMed id 15123618)^{1, 3} Lin H....Wang P.S. (2004)
HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cells. (PubMed id 18247371)^{1, 3} Darbinian N....Amini S. (2008)
Cdk5 regulates the organization of Nestin and its association with p35. (PubMed id 12832492)^{1, 3} Sahlgren C.M....Eriksson J.E. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8851	HGNC: 1775	AceView: CDK5R1	Ensembl:ENSG00000176749	euGenes: HUgn8851
ECgene: CDK5R1	H-InvDB: CDK5R1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDK5R1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdk5r1/

Licensable Technologies for CDK5R1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDK5R1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDK5R1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDK5R1		Antibodies for CDK5R1
	Explore super-pooled esiRNAs		Proteins for CDK5R1
	Lentivirus-delivered shRNAs for CDK5R1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDK5R1)
	Antibodies (CDK5R1)
	Chimera RNAi (CDK5R1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDK5R1 (p35)

	Recombinant Proteins (p35 + p25, p35)
	Antibodies (p35 + p25, p35)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CDK5R1

	Drugs/Proteins for CDK5R1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDK5R1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDK5R1 Gene at Home site.
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CDK5R1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CDK5R1

Summaries
for CDK5R1

Genomic Location
for CDK5R1

Proteins
for CDK5R1

Protein Domains/
Families
for CDK5R1

Gene Function
for CDK5R1

Pathways & Interactions
for CDK5R1

Drugs & Compounds
for CDK5R1

Transcripts
for CDK5R1

Expression
for CDK5R1

Orthologs
for CDK5R1

Paralogs
for CDK5R1

SNPs/Variants
for CDK5R1

Disorders & Mutations
for CDK5R1

Medical News
for CDK5R1

Publications
for CDK5R1

Search for CDK5R1

Genome Databases showing CDK5R1

Other Databases showing CDK5R1

Specialized Databases showing CDK5R1

Licensable Technologies
for CDK5R1

Services
for CDK5R1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDK5R1 (Gene Symbol)
CDK5P35
CDK5R
MGC33831
NCK5A
Nck5a
p23
p25
p35
p35nck5a
CDK5 activator 1
Cyclin-dependent kinase 5 regulatory subunit 1
TPKII regulatory subunit
Tau protein kinase II 23 kDa subunit
cyclin-dependent kinase 5 activator 1
cyclin-dependent kinase 5, regulatory subunit 1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
neuronal CDK5 activator
regulatory partner for CDK5 kinase
tau protein kinase II 23kDa subunit

CDK5R1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CDK5R1

Summariesfor CDK5R1

Genomic Locationfor CDK5R1

Proteinsfor CDK5R1

Protein Domains/Familiesfor CDK5R1

Gene Functionfor CDK5R1

Pathways & Interactionsfor CDK5R1

Drugs & Compoundsfor CDK5R1

Transcriptsfor CDK5R1

Expression for CDK5R1

Orthologsfor CDK5R1

Paralogsfor CDK5R1

SNPs/Variantsfor CDK5R1

Disorders & Mutationsfor CDK5R1

Medical Newsfor CDK5R1

Publicationsfor CDK5R1

Search for CDK5R1

Genome Databases showing CDK5R1

Other Databases showing CDK5R1

Specialized Databases showing CDK5R1

Licensable Technologiesfor CDK5R1

Servicesfor CDK5R1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDK5R1

Summaries
for CDK5R1

Genomic Location
for CDK5R1

Proteins
for CDK5R1

Protein Domains/
Families
for CDK5R1

Gene Function
for CDK5R1

Pathways & Interactions
for CDK5R1

Drugs & Compounds
for CDK5R1

Transcripts
for CDK5R1

Expression
for CDK5R1

Orthologs
for CDK5R1

Paralogs
for CDK5R1

SNPs/Variants
for CDK5R1

Disorders & Mutations
for CDK5R1

Medical News
for CDK5R1

Publications
for CDK5R1

Licensable Technologies
for CDK5R1

Services
for CDK5R1