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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK5 Gene

protein-coding   GIFtS: 74
GCID: GC07M150750

Cyclin-Dependent Kinase 5

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 51 2     EC 2.7.11.223 8
Cell Division Protein Kinase 52 3     PSSALRE2
Serine/Threonine-Protein Kinase PSSALRE2 3     Protein Kinase CDK5 Splicing2
Tau Protein Kinase II Catalytic Subunit2 3     CDKN53
TPKII Catalytic Subunit2 3     EC 2.7.118

External Ids:    HGNC: 17741   Entrez Gene: 10202   Ensembl: ENSG000001648857   OMIM: 1238315   UniProtKB: Q005353   

Export aliases for CDK5 gene to outside databases

Previous GC identifers: GC07M148997 GC07M150065 GC07M150142 GC07M150188 GC07M150381 GC07M144563


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDK5 Gene: 
CDK5 (cyclin-dependent kinase 5) is a protein-coding gene. Diseases associated with CDK5 include aneurysmal bone cysts, and tauopathy, and among its related super-pathways are Development Slit-Robo signaling and Parkinson's disease. GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and
differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell
cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1,
MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42,
TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and
NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration
and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic
plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and
CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation
loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA,
CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate
neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,
SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at
synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by
phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle
exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating
anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of
p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin
ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating
apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis
producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle
activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes
neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons
protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN
reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)
differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT
(IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional
regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA
synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex.
Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of
TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by
phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1
AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and
contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC
phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May
regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in
dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling

summary for CDK5 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK5 (Cyclin-dependent kinase 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK5 gene promoter:
         p53   p300   C/EBPalpha   PPAR-gamma1   E2F-1   E2F   HOXA5   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

CDK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150750:  view genomic region     (about GC identifiers)

Start:
150,750,899 bp from pter      End:
150,755,617 bp from pter
Size:
4,719 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,080,438-150,084,591     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5  
Size: 292 amino acids; 33304 Da
Subunit: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular
complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows
kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate
p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex
with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds
to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes.
Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1.
Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts
with PTK2/FAK1 (By similarity)
Subcellular location: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell
projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse,
postsynaptic cell membrane, postsynaptic density (By similarity). Note=In axonal growth cone with extension to
the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35)
is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level
of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation.
Co-localizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma
membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane
in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this
attachment and activates CDK5
Subcellular location: Isoform 2: Nucleus
Miscellaneous: Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson,
and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis
6/7 PDB 3D structures from and Proteopedia for CDK5 (see all 7):
1H4L (3D)        1LFR (3D)        1UNG (3D)        1UNH (3D)        1UNL (3D)        3O0G (3D)    
Secondary accessions: A1XKG3
Alternative splicing: 2 isoforms:  Q00535-1   Q00535-2   

Explore the universe of human proteins at neXtProt for CDK5: NX_Q00535

Explore proteomics data for CDK5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By
    contrast, phosphorylation at Thr-14 inhibits activity
  • UniProtKB: Phosphorylation at Ser-159 is essential for maximal catalytic activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00535

  • 4/20 DME Specific Peptides for CDK5 (Q00535) (see all 20)
     WSAGCIF  LGTPTEE  VVTLWYR  LVFEFCD 

    CDK5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157882.1  NP_004926.1  

    ENSEMBL proteins: 
     ENSP00000419782   ENSP00000297518  
    Reactome Protein details: Q00535
    Human Recombinant Protein Products for CDK5: 
    EMD Millipore Purified and/or Recombinant CDK5 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CDK5
    OriGene Purified Protein for CDK5
    OriGene Protein Over-expression Lysate for CDK5
    OriGene MassSpec for CDK5 
    OriGene Custom Protein Services for CDK5
    GenScript Custom Purified and Recombinant Proteins Services for CDK5
    Novus Biologicals CDK5 Proteins
    Novus Biologicals CDK5 Lysates
    Sino Biological Recombinant Protein for CDK5
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CDK5
    Cloud-Clone Corp. Proteins for CDK5 

    Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IEA--

    CDK5 for ontologies           About GeneDecksing



    CDK5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK5
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDK5 
    OriGene Antibodies for CDK5
    OriGene Custom Antibody Services for CDK5
    GenScript Superior Antibodies for CDK5
    Novus Biologicals CDK5 Antibodies
    Abcam antibodies for CDK5
    Cloud-Clone Corp. Antibodies for CDK5 
    ThermoFisher Antibody for CDK5
    LSBio Antibodies in human, mouse, rat for CDK5 

    Assay Products for CDK5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK5 
    Cloud-Clone Corp. CLIAs for CDK5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 5 
    CDK5 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q00535

    ProtoNet protein and cluster: Q00535

    UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK5_HUMAN, Q00535
    Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and
    differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell
    cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1,
    MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42,
    TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and
    NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration
    and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic
    plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and
    CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation
    loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA,
    CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate
    neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,
    SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at
    synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by
    phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle
    exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating
    anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of
    p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin
    ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating
    apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis
    producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle
    activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes
    neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons
    protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN
    reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)
    differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT
    (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional
    regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA
    synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex.
    Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of
    TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by
    phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1
    AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and
    contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC
    phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May
    regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in
    dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine),
    1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1
    (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39)
    by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and
    induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35
    available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term
    inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity
    of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived
    neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and
    neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and
    inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents
    neurodegeneration

         Genatlas biochemistry entry for CDK5:
    cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for
    activation with its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with
    cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and
    cAMP regulated and modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant
    increase in CDK5 kinase activity,hyperphosphorylation of tau which reduces tau's ability to associate
    microtubules

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IEA--
    GO:0004672protein kinase activity TAS1639063
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004693cyclin-dependent protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
         
    CDK5 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CDK5:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased Salmonella enterica  
     Increased colony dispersion (i  PARP inhibitor sensitization  Wnt reporter downregulated 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cdk5):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  nervous system 
     no phenotypic analysis  normal  respiratory system 

    CDK5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDK5: Cdk5tm1Kul Cdk5tm1.2Lht

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK5:
    hsa-miR-142-5p hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidCDK5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5

    Gene Editing
    Products:
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    Sirion Biotech Validated adenovirus to knockdown CDK5 in human, mouse 
                         Customized adenovirus for overexpression of CDK5

    Clone
    Products:
         
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    OriGene clones in human, mouse for CDK5 (see all 14)
    OriGene ORF clones in mouse, rat for CDK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410)
    Sino Biological Human cDNA Clone for CDK5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
    Sirion Biotech Customized lentivirus for stable overexpression of CDK5 
                         Customized lentivirus expression plasmids for stable overexpression of CDK5 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK5 About   (see all 34)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Cytoskeleton remodeling Slit-Robo signaling0.92
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    5Axon guidance
    Axon guidance0.69
    Developmental Biology0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for CDK5
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Slit-Robo signaling

    8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK5 (see first 5)
        Reelin Pathway (Cajal-Retzius cells)
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling
    GADD45 Pathway
    Cell Cycle Control of Chromosomal Replication
    Alzheimers Disease Pathway
    CDK5 Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CDK5
        Cell Cycle / Checkpoint Control
    Neuroscience

    5 GeneGo (Thomson Reuters) Pathways for CDK5
        Neurophysiological process Receptor-mediated axon growth repulsion
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Slit-Robo signaling
    Cytoskeleton remodeling Neurofilaments
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/10 BioSystems Pathways for CDK5 (see all 10)
        DNA damage response
    Nicotine Activity on Dopaminergic Neurons
    BDNF signaling pathway
    IL-6 Signaling Pathway
    Alzheimers Disease


    5/10        Reactome Pathways for CDK5 (see all 10)
        CRMPs in Sema3A signaling
    Hemostasis
    Developmental Biology
    Signaling by GPCR
    Opioid Signalling

    1 PharmGKB Pathway for CDK5
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    3         Kegg Pathways  (Kegg details for CDK5):
        Axon guidance
    Alzheimer's disease
    Cocaine addiction


    CDK5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for CDK5 (Q005351, 2, 3 ENSP000002975184) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1BP465271, 3, ENSP000002288724EBI-1041567,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    MAPTP106362, 3, ENSP000003408204MINT-3974182 I2D: score=2 STRING: ENSP00000340820
    CDK5R1Q150781, 3, ENSP000003184864EBI-1041567,EBI-746189 I2D: score=11 STRING: ENSP00000318486
    PPP1CAP621362, 3, ENSP000003260314MINT-8286903 I2D: score=1 STRING: ENSP00000326031
    CRELD2Q6UXH12, 3MINT-8251466 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/76 biological process terms (GO ID links to tree view) (see all 76):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration TAS--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0006468protein phosphorylation ----
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis ----

    CDK5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK5 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK5:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CDK5

    Compounds for CDK5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    7 DrugBank Compounds for CDK5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Indirubin-3'-Monoxime-- --targetinhibitor11752352 10592235
    6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE-- --target--10592235
    Alsterpaullone-- --target--11752352
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    Hymenialdisine-- --targetinhibitor11752352
    Olomoucine-- 101622-51-9targetinhibitor11752352
    SU9516-- --targetinhibitor11752352

    10/48 Novoseek inferred chemical compound relationships for CDK5 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 92.4 97 17081516 (5), 19628755 (3), 16802322 (2), 16770643 (2) (see all 54)
    olomoucine 83.5 21 10770290 (2), 18385789 (2), 16815303 (1), 19522735 (1) (see all 10)
    butyrolactone i 75.2 6 15051507 (1), 11882652 (1), 7592534 (1), 11978846 (1)
    purvalanol 68.2 1 16611631 (1)
    glycogen 66.9 71 8627328 (2), 11805297 (2), 16818492 (2), 20211702 (2) (see all 42)
    kenpaullone 64.7 1 15950951 (1)
    threonine 63.9 52 19442718 (1), 19343042 (1), 17697781 (1), 17341134 (1) (see all 28)
    serine 55.4 57 18755796 (1), 19442718 (1), 19343042 (1), 10413323 (1) (see all 33)
    flavopiridol 51.2 2 12941380 (2)
    gamma-butyrolactone 37.3 4 15056716 (1), 18512759 (1), 15369765 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK5 gene (2 alternative transcripts): 
    NM_001164410.1  NM_004935.3  

    Unigene Cluster for CDK5:

    Cyclin-dependent kinase 5
    Hs.647078  [show with all ESTs]
    Unigene Representative Sequence: BG577212
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485972(uc022apy.1 uc003wir.2 uc003wis.2) ENST00000297518
    ENST00000487703 ENST00000476691 ENST00000469108

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK5:
    hsa-miR-142-5p hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidCDK5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5
    Clone
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    OriGene clones in human, mouse for CDK5 (see all 14)
    OriGene ORF clones in mouse, rat for CDK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
    Sirion Biotech Customized lentivirus for stable overexpression of CDK5 
                         Customized lentivirus expression plasmids for stable overexpression of CDK5 
    Primer
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    OriGene qPCR primer pairs and template standards for CDK5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5

    Additional mRNA sequence: 

    AK026533.1 AY049778.1 AY927560.1 BC005115.1 BT006680.1 CR457041.1 DQ411039.1 L04658.1 
    X66364.1 

    11 DOTS entries:

    DT.319808  DT.97839636  DT.121074391  DT.100022516  DT.121074369  DT.121074491  DT.95132417  DT.95372485 
    DT.95372486  DT.121074488  DT.92466216 

    24/122 AceView cDNA sequences (see all 122):

    AI306490 BT006680 BF434699 BV177642 N52899 AY049778 AV709223 CB144453 
    AA482510 AA306623 NM_004935 CF128142 AA952919 BE673479 BU529114 BC005115 
    AK026533 AI086997 CA431641 CA429180 BX112764 BX489021 BM727541 BM040737 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:        -                                         -                 -                                                   
    SP2:                                                  -                 -                                                   
    SP3:        -           -                             -                 -                                                   
    SP4:                                                  -     -                                                               
    SP5:        -                                         -     -           -                                                   


    ECgene alternative splicing isoforms for CDK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK5 expression in normal human tissues (normalized intensities)      CDK5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCAGCCG
    CDK5 Expression
    About this image


    CDK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See CDK5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK5

    SOURCE GeneReport for Unigene cluster: Hs.647078

    UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
    Tissue specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level).
    Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK5: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDK5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK5 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk51 , 5 cyclin-dependent kinase 51, 5 90.87(n)1
    99.66(a)1
      5 (11.73 cM)5
    125681  NM_007668.31  NP_031694.11 
     244182505 
    chicken
    (Gallus gallus)
    Aves CDK51 cyclin-dependent kinase 5 83.56(n)
    97.26(a)
      100190948  NM_001135786.1  NP_001129258.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.672 Xenopus laevis neuronal cyclin-dependent kinase 5 (cdk5) more 81.87(n)    U24397.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk52 cyclin-dependent protein kinase 5 78.02(n)   65234  AF203736.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk51 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Cyclin-dependent kinase 51
    79(a)
    (best of 2)3
    70.72(n)1
    79.17(a)1
      2 52A133
    367271  NM_057732.31  NP_477080.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H01G02.23
    cdk-51
    serine/threonine kinase (2 domains)3
    Protein CDK-51
    35(a)3
    64.7(n)1
    74.65(a)1
      IV(11798872-11801260)3
    1767741  NM_067382.61  NP_499783.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO851 Pho85p 60.23(n)
    58.25(a)
      856076   NP_015294.1 


    ENSEMBL Gene Tree for CDK5 (if available)
    TreeFam Gene Tree for CDK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK5 gene
    CDK182  CDK62  CDK152  CDK12  CDK42  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/63 SIMAP similar genes for CDK5 using alignment to 2 protein entries:     CDK5_HUMAN (see all proteins) (see all similar genes):
    CDK3    CDK18    CDK16    CDK17    PCTK1    CDK1
    CDC2    PCTK3    DKFZp686L20222    CDK15    CDK14    CDC2L1
    CDC2L2    CDK11A    CDK11B    CDK7    CCRK    CDK6

    CDK5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK5
    PGOHUM00000249786


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/81 SNPs in CDK5 are shown (see all 81)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859225671,2
    C--150750511(+) CATATA/CTTTGG 2 -- int10--------
    rs125375231,2
    C,H--150750566(+) TGAGGG/AAAAGG 2 -- int13Minor allele frequency- A:0.22NA EA 242
    rs1449822501,2
    --150750961(+) AATTCA/GGGCTC 2 -- ut310--------
    rs1168631651,2
    F--150750978(+) CCCACC/TCCGGC 2 -- ut311Minor allele frequency- T:0.01EA 120
    rs92781,2
    C,F--150750980(-) CAGCCG/AGGGTG 2 -- ut31 ese311Minor allele frequency- A:0.14NA MN WA 1090
    rs20694611,2
    C,F--150750981(-) CCAGCC/TGGGGT 2 -- ut31 ese36Minor allele frequency- T:0.00NA MN 452
    rs350514461,2
    F--150751010(-) TGGTGC/TGCTGT 2 -- ut315Minor allele frequency- T:0.01MN 404
    rs796273161,2
    C--150751081(-) CCCCCA/GGCCTC 2 -- ut310--------
    rs20694601,2
    C,F--150751091(-) GGCCCC/TGGGAC 2 -- ut31 ese37Minor allele frequency- T:0.01NA MN EA 644
    rs115416021,2
    C--150751132(-) GCCCTG/TCAGCA 4 L syn12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for CDK5 (150750899 - 150755617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CDK5:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv7546n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv889465CNV Loss21882294
    nsv526410CNV Loss19592680
    nsv889471CNV Loss21882294
    dgv7545n71CNV Loss21882294
    nsv831188CNV Loss17160897
    nsv889476CNV Loss21882294
    nsv524928CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK5
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123831    OMIM disorders: --

    20/57 diseases for CDK5 (see all 57):    About MalaCards
    aneurysmal bone cysts    tauopathy    multiple system atrophy    miller-dieker syndrome
    transient cerebral ischemia    differentiating neuroblastoma    ganglioglioma    toxic encephalopathy
    progressive supranuclear palsy    inclusion body myositis    brain disease    lateral sclerosis
    amyotrophic lateral sclerosis    hereditary spastic paraplegia    myositis    ischemia
    lissencephaly    herpes simplex    motor neuron disease    paraplegia

    4 diseases from the University of Copenhagen DISEASES database for CDK5:
    Alzheimer's disease     Amyotrophic lateral sclerosis     Toxic encephalopathy     Lissencephaly

    CDK5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/36 Novoseek inferred disease relationships for CDK5 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 78.2 14 8870824 (2), 9666145 (1), 12719630 (1), 19154537 (1) (see all 10)
    alzheimers disease 75.3 69 9666145 (2), 18350355 (2), 16413130 (2), 15917097 (2) (see all 43)
    tauopathies 74.9 3 17113760 (2), 17908241 (1)
    paired helical filament 74.5 8 9666145 (1), 15975083 (1), 8870824 (1), 11065131 (1) (see all 5)
    neurodegeneration 71.2 40 16932754 (4), 15009631 (2), 14673208 (2), 17932412 (2) (see all 26)
    neurodegenerative diseases 71.1 66 17979810 (4), 16600851 (2), 17003520 (2), 15135890 (2) (see all 36)
    amyotrophic lateral sclerosis 57.5 22 14673208 (2), 9596352 (2), 11464850 (2), 10509378 (1) (see all 14)
    senile plaques 43.9 2 12719630 (1), 14681576 (1)
    brain diseases 42.8 3 17241267 (1), 15917097 (1)
    parkinson disease 38.6 13 9255390 (2), 20504213 (2), 19075597 (1), 7485409 (1) (see all 6)

    Genetic Association Database (GAD): CDK5
    Human Genome Epidemiology (HuGE) Navigator: CDK5 (52 documents)

    Export disorders for CDK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK5 gene, integrated from 9 sources (see all 634):
    (articles sorted by number of sources associating them with CDK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (1992)
    2. Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. (PubMed id 10500146)1, 2, 9 Sharma P....Pant H.C. (1999)
    3. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PubMed id 17591690)1, 2, 9 Lee J.H....Kim K.T. (2007)
    4. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PubMed id 12691662)1, 2, 9 Gong X....Mao Z. (2003)
    5. Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. (PubMed id 18350355)1, 4, 9 Arias-Vasquez A....van Duijn C.M. (2008)
    6. Structure and regulation of the CDK5-p25(nck5a) complex. (PubMed id 11583627)1, 2, 9 Tarricone C....Musacchio A. (2001)
    7. CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. (PubMed id 20213743)1, 2, 9 Lee C.H....Lu P.J. (2010)
    8. Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. (PubMed id 19343042)1, 4, 9 Choi H.S....Kim Y.H. (2009)
    9. No association of CDK5 genetic variants with Alzheime r's disease risk. (PubMed id 19615060)1, 4, 9 VA!zquez-Higuera J.L....Combarros O. (2009)
    10. Cdk5 regulates differentiation of oligodendrocyte pre cursor cells through the direct phosphorylation of paxillin. (PubMed id 18042622)1, 2, 9 Miyamoto Y....Tanoue A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1020 HGNC: 1774 AceView: CDK5 Ensembl:ENSG00000164885 euGenes: HUgn1020
    ECgene: CDK5 Kegg: 1020 H-InvDB: CDK5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK5 gene:
    Search GeneIP for patents involving CDK5

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for CDK5
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK5
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant CDK5 Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
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     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
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     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDK5   OriGene RNAi products in human, mouse, rat for CDK5  
     OriGene qPCR primer pairs and template standards for CDK5   OriGene Protein Over-expression Lysate for CDK5  
     OriGene MassSpec something-or-other for CDK5   OriGene clones in human, mouse for CDK5  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK5   OriGene Purified Protein for CDK5  
     OriGene ORF clones in mouse, rat for CDK5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK5   OriGene Custom Protein Services for CDK5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK5
     QIAGEN SeqTarget long-range PCR primers for resequencing CDK5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5
     GenScript Custom Purified and Recombinant Proteins Services for CDK5 GenScript cDNA clones with any tag delivered in your preferred vector for CDK5
     GenScript Custom Assay Services for CDK5 GenScript Superior Antibodies for CDK5
     GenScript Custom overexpressing Cell Line Services for CDK5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CDK5 

     Regulatory tfbs in CDK5 promoter
     Search Chromatin IP Primers for CDK5
     RT2 qPCR Primer Assay in human, mouse, rat CDK5
     GNC Network for CDK5
     SABiosciences PCR Arrays including human, mouse, rat CDK5
     Tocris compounds for CDK5
     Proteins and Antibodies for CDK5
     Browse Sino Biological Cell Lysates
     cDNA Clones for CDK5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for CDK5
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK5 antibodies
     CDK5 proteins
     CDK5 lysates
     Antibodies for CDK5
     See all of Abcam's Antibodies, Kits and Proteins for CDK5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CDK5




     Proteins for CDK5
     Antibodies for CDK5
     ELISAs for CDK5
     CLIAs for CDK5
     Search LifeMap BioReagents cell lines for CDK5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5
     SwitchGear 3'UTR luciferase reporter plasmids for CDK5
     SwitchGear Promoter luciferase reporter plasmids for CDK5
     ThermoFisher Antibody for CDK5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK5
     Validated adenovirus to knockdown CDK5 in human, mouse

    Customized:
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     lentivirus expression plasmids for stable overexpression of CDK5
     adenovirus for overexpression of CDK5
     LSBio Antibodies in human, mouse, rat for CDK5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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