CDK5 Gene
protein-coding GIFtS: 69
GCID: GC07M150750
|
|
cyclin-dependent kinase 5
| |
Aliases
for CDK5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin-Dependent Kinase 51 2 | | TPKII Catalytic Subunit2 3 | | PSSALRE1 2 | | EC 2.7.11.223 8 | | Cell Division Protein Kinase 52 3 | | Protein Kinase CDK5 Splicing2 | | Serine/Threonine-Protein Kinase PSSALRE2 3 | | CDKN53 | | Tau Protein Kinase II Catalytic Subunit2 3 | | EC 2.7.118 |
Export aliases for CDK5 gene to outside databasesPrevious GC identifers: GC07M148997 GC07M150065 GC07M150142 GC07M150188 GC07M150381 GC07M144563 |
Summaries
for CDK5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiationand may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interactswith D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN,PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1,p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal developmentand physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth,synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating keyproteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, andpromotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho andRas family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B),and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosisassociated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteinssuch as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulatesneurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapseplasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cellsurvival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity.Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventingubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thusregulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediatedproteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrantcell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks thatprecedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei ofneurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation ofPXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activatedinhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatorygenes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in aIFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is requiredfor autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates itsrapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leadingto neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation ofDNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels.SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Mayregulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved indendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling
 summary
for CDK5: Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.
Gene Wiki entry for CDK5 (Cyclin-dependent kinase 5)
|
Genomic Views
for CDK5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDK5 gene promoter:
p53 p300 C/EBPalpha PPAR-gamma1 E2F-1 E2F HOXA5 PPAR-gamma2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDK5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36CDK5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M150750: view genomic region
(about GC identifiers)
Start:
|
150,750,899 bp from pter |
End:
|
150,755,617 bp from pter |
Size:
|
4,719 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 150,080,438-150,084,591 |
|
Proteins
for CDK5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 (See
protein sequence)Recommended Name: Cyclin-dependent kinase 5 Size: 292 amino acids; 33304 Da
Subunit: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecularcomplex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer showskinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex withCABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 inneurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity)
Subcellular location: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection,lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, postsynaptic cellmembrane, postsynaptic density (By similarity). Note=In axonal growth cone with extension to the peripherallamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved bycalpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when incomplex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Co-localizes with CTNND2 inthe cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated anddifferentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed todephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5
Subcellular location: Isoform 2: Nucleus
Miscellaneous: Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, andNiemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis
6 PDB 3D structures from  and Proteopedia  for CDK5:1H4L (3D)
1LFR (3D)
1UNG (3D)
1UNH (3D)
1UNL (3D)
3O0G (3D)
Secondary accessions: A1XKG3Alternative splicing: 2 isoforms: Q00535-1 Q00535-2 Explore the universe of human proteins at neXtProt for CDK5: NX_Q00535
Post-translational modifications:
Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast,phosphorylation at Thr-14 inhibits activity1
Phosphorylation at Ser-159 is essential for maximal catalytic activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q00535
4/20 DME Specific Peptides for CDK5 (Q00535) (see all 20)
CDK5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001157882.1 NP_004926.1
ENSEMBL proteins: ENSP00000419782 ENSP00000297518 Reactome Protein details: Q00535
Human Recombinant Protein Products:
Gene Ontology (GO): 5/20 cellular component terms (GO ID links to tree view) (see all 20): About this table
CDK5 for ontologies About GeneDecksing
CDK5 Antibody Products:
Assay Products for CDK5: |
Protein
Domains /
Families
for CDK5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDK5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q00535ProtoNet protein and cluster: Q00535 UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CDK5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiationand may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interactswith D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN,PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1,p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal developmentand physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth,synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating keyproteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, andpromotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho andRas family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B),and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosisassociated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteinssuch as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulatesneurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapseplasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cellsurvival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity.Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventingubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thusregulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediatedproteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrantcell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks thatprecedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei ofneurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation ofPXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activatedinhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatorygenes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in aIFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is requiredfor autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates itsrapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leadingto neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation ofDNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels.SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Mayregulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved indendritic spine morphogenesis by mediating the EFNA1-EPHA4 signalingCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine),1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1(p35) and ATP6V0D1 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and ATP6V0D1 (p39)by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and inducesits ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available andsubcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well asCDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 issuppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor,glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity.Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis ofcortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration Genatlas biochemistry entry for CDK5:cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for activationwith its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with cyclin D(D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and cAMP regulatedand modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant increase in CDK5kinase activity,hyperphosphorylation of tau which reduces tau's ability to associate microtubules
Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410) | |  | Sino Biological Human cDNA Clone for CDK5 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table
CDK5 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for CDK5:
Animal Models:
Mouse knock-outs for CDK5: Cdk5tm1Kul Cdk5tm1.2Lht
8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Cdk5):
CDK5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CDK5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Opioid Signalling | | | 2 | Signaling by GPCR | | | 3 | Axon guidance | | | 4 | Cytoskeleton remodeling Slit-Robo signaling | | | 5 | Cytoskeleton remodeling Neurofilaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for CDK5
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK5 (see all 8)
2 
Cell Signaling Technology (CST) Pathways for CDK5
5  GeneGo (Thomson Reuters) Pathways for CDK5
5/9  BioSystems Pathways for CDK5 (see all 9)
5/10 
Reactome Pathways for CDK5 (see all 10)
1  PharmGKB Pathway for CDK5
2 
Kegg Pathways (Kegg details for CDK5):
CDK5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/129 Interacting proteins for CDK5 (Q005351, 2, 3 ENSP000002975184) via UniProtKB, MINT, STRING, and/or I2D (see all 129)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CDKN1B | P465271, 3, ENSP000002288724 | EBI-1041567,EBI-519280 I2D:
score=3 STRING: ENSP00000228872 | | MAPT | P106362, 3, ENSP000003408204 | MINT-3974182 I2D:
score=2 STRING: ENSP00000340820 | | CDK5R1 | Q150781, 3, ENSP000003184864 | EBI-1041567,EBI-746189 I2D:
score=11 STRING: ENSP00000318486 | | PPP1CA | P621362, 3, ENSP000003260314 | MINT-8286903 I2D:
score=1 STRING: ENSP00000326031 | | CRELD2 | Q6UXH12, 3 | MINT-8251466 I2D:
score=1 |
About this table
Gene Ontology (GO): 5/77 biological process terms (GO ID links to tree view) (see all 77): About this table
CDK5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDK5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDK5 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CDK5 |
Compounds for CDK5 available from Tocris Bioscience About this table
2 HMDB Compounds for CDK5 About this table
7 DrugBank Compounds for CDK5 About this table
10/48 Novoseek chemical compound relationships for CDK5 gene (see all 48) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| roscovitine |
92.4 |
97 |
17081516 (5), 19628755 (3), 16802322 (2), 16770643 (2) (see all 54) |
| olomoucine |
83.5 |
21 |
10770290 (2), 18385789 (2), 16815303 (1), 19522735 (1) (see all 10) |
| butyrolactone i |
75.2 |
6 |
15051507 (1), 11882652 (1), 7592534 (1), 11978846 (1) |
| purvalanol |
68.2 |
1 |
16611631 (1) |
| glycogen |
66.9 |
71 |
8627328 (2), 11805297 (2), 16818492 (2), 20211702 (2) (see all 42) |
| kenpaullone |
64.7 |
1 |
15950951 (1) |
| threonine |
63.9 |
52 |
19442718 (1), 19343042 (1), 17697781 (1), 17341134 (1) (see all 28) |
| serine |
55.4 |
57 |
18755796 (1), 19442718 (1), 19343042 (1), 10413323 (1) (see all 33) |
| flavopiridol |
51.2 |
2 |
12941380 (2) |
| gamma-butyrolactone |
37.3 |
4 |
15056716 (1), 18512759 (1), 15369765 (1) |
Search CenterWatch for drugs/clinical trials and news about CDK5
|
Transcripts
for CDK5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDK5 gene (2 alternative transcripts): NM_001164410.1 NM_004935.3 Unigene Cluster for CDK5: Cyclin-dependent kinase 5 Hs.647078 [show with all ESTs]Unigene Representative Sequence: BG5772125 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485972(uc022apy.1 uc003wir.2 uc003wis.2) ENST00000297518
ENST00000487703 ENST00000476691 ENST00000469108
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5 |
Additional cDNA sequence: AK026533.1 AY049778.1 AY927560.1 BC005115.1 BT006680.1 CR457041.1 DQ411039.1 L04658.1 X66364.1 11 DOTS entries: DT.319808 DT.97839636 DT.121074391 DT.100022516 DT.121074369 DT.121074491 DT.95132417 DT.95372485 DT.95372486 DT.121074488 DT.92466216 24/122 AceView cDNA sequences (see all 122): BX112764 AA306623 CB144453 BF434699 AA482510 BV177642 CF128142 AY049778 BM727541 BU529114 BC005115 AV709223 BE673479 CA431641 AI086997 NM_004935 N52899 CA429180 BX489021 AI306490 AK026533 BT006680 AA952919 CR457041
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDK5
|
Expression
for CDK5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTCAGCCG
About this image
See CDK5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK5
SOURCE GeneReport for Unigene cluster: Hs.647078
UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535Tissue specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2has only been detected in testis, skeletal muscle, colon, bone marrow and ovary
SABiosciences Expression via Pathway-Focused PCR Arrays including CDK5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5 |
Orthologs
for CDK5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CDK5 gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for CDK5 (if available)
TreeFam Gene Tree for CDK5 (if available) |
Paralogs
for CDK5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDK5 gene
- CDK62 CDK182 CDK152 CDK42 CDK12 CDK32 CDK142 CDK162
- CDK22 CDK172
18/62 SIMAP similar genes for CDK5 using alignment to 2 protein entries: CDK5_HUMAN (see all proteins)
(see all similar genes):CDK3 CDK18 CDK16 CDK17 PCTK1 CDK1
CDC2 PCTK3 DKFZp686L20222 CDK15 CDK14 CDC2L1
CDC2L2 CDK11A CDK11B CDK7 CDK6 CDK2
CDK5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CDK5
PGOHUM00000249786
|
Genomic Variants
for CDK5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDK5 (150750899 - 150755617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDK5
1 CNV: 4574 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CDK5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDK5 for disorders About GeneDecksing
OMIM gene information: 123831
OMIM disorders: --
20/66  diseases for CDK5 (see all 66): About MalaCardsmiller-dieker syndrome supranuclear palsy amyotrophic lateral sclerosis amyotrophic lateral sclerosis (als)
inclusion body myositis focal cortical dysplasia progressive supranuclear palsy spastic paraplegia
hereditary spastic paraplegia aneurysmal bone cysts leukemia lateral sclerosis
multiple system atrophy transient cerebral ischemia corpus callosum intractable epilepsy
herpes simplex polycystic ovary syndrome paraplegia toxic encephalopathy
4 diseases from the University of Copenhagen DISEASES database for CDK5:Alzheimer's disease Amyotrophic lateral sclerosis Toxic encephalopathy Lissencephaly 10/36 Novoseek disease relationships for CDK5 gene (see all 36) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neurofibrillary tangles |
78.2 |
14 |
8870824 (2), 9666145 (1), 12719630 (1), 19154537 (1) (see all 10) |
| alzheimers disease |
75.3 |
69 |
9666145 (2), 18350355 (2), 16413130 (2), 15917097 (2) (see all 43) |
| tauopathies |
74.9 |
3 |
17113760 (2), 17908241 (1) |
| paired helical filament |
74.5 |
8 |
9666145 (1), 15975083 (1), 8870824 (1), 11065131 (1) (see all 5) |
| neurodegeneration |
71.2 |
40 |
16932754 (4), 15009631 (2), 14673208 (2), 17932412 (2) (see all 26) |
| neurodegenerative diseases |
71.1 |
66 |
17979810 (4), 16600851 (2), 17003520 (2), 15135890 (2) (see all 36) |
| amyotrophic lateral sclerosis |
57.5 |
22 |
14673208 (2), 9596352 (2), 11464850 (2), 10509378 (1) (see all 14) |
| senile plaques |
43.9 |
2 |
12719630 (1), 14681576 (1) |
| brain diseases |
42.8 |
3 |
17241267 (1), 15917097 (1) |
| parkinson disease |
38.6 |
13 |
9255390 (2), 20504213 (2), 19075597 (1), 7485409 (1) (see all 6) |
Human Genome Epidemiology (HuGE) Navigator: CDK5 (52 documents)
Export disorders for CDK5 gene to outside databases
|
Publications
for CDK5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDK5 gene, integrated from 9 sources (see all 618):
(articles sorted by number of sources associating them with CDK5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (1992)
- Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. (PubMed id 10500146)1, 2, 9 Sharma P....Pant H.C. (1999)
- Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PubMed id 17591690)1, 2, 9 Lee J.H....Kim K.T. (2007)
- Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PubMed id 12691662)1, 2, 9 Gong X....Mao Z. (2003)
- Structure and regulation of the CDK5-p25(nck5a) complex. (PubMed id 11583627)1, 2, 9 Tarricone C....Musacchio A. (2001)
- CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. (PubMed id 20213743)1, 2, 9 Lee C.H....Lu P.J. (2010)
- Cdk5 regulates differentiation of oligodendrocyte pre cursor cells through the direct phosphorylation of paxillin. (PubMed id 18042622)1, 2, 9 Miyamoto Y....Tanoue A. (2007)
- Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. (PubMed id 21465480)1, 2 Lee K.Y.... Rosales J.L. (2012)
- Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. (PubMed id 21415596)1, 2 Zhang J. and Herrup K. (2011)
- Cdk5: Mediator of neuronal development, death and the response to DNA damage. (PubMed id 21600237)1, 2 Zhu J.... Mao Z. (2011)
|
External Searches for CDK5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDK5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDK5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDK5 gene:
Search GeneIP for patents involving CDK5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDK5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CDK5 | | OriGene shRNA RFP for CDK5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK5 | | | OriGene Protein Over-expression Lysate for CDK5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDK5 | | OriGene 3'-UTR Clone for CDK5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CDK5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDK5 | | OriGene Custom Protein Services for CDK5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK5 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK5 |
| |
 |  |  |  | |
| | Antibodies & Assays for CDK5 |
| | | | Tocris compounds for CDK5 |
| |  |  |  |  | | | | |
 |
 |
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 | | | CDK5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5 |
|  |  |  | | | | ThermoFisher Antibody for CDK5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5 |
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