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CDK5 Gene

protein-coding   GIFtS: 74
GCID: GC07M150750

Cyclin-Dependent Kinase 5

  See CDK5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 51 2     EC 2.7.11.223 8
Cell Division Protein Kinase 52 3     PSSALRE2
Serine/Threonine-Protein Kinase PSSALRE2 3     Protein Kinase CDK5 Splicing2
Tau Protein Kinase II Catalytic Subunit2 3     CDKN53
TPKII Catalytic Subunit2 3     EC 2.7.118

External Ids:    HGNC: 17741   Entrez Gene: 10202   Ensembl: ENSG000001648857   OMIM: 1238315   UniProtKB: Q005353   

Export aliases for CDK5 gene to outside databases

Previous GC identifers: GC07M148997 GC07M150065 GC07M150142 GC07M150188 GC07M150381 GC07M144563


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDK5 Gene:
CDK5 (cyclin-dependent kinase 5) is a protein-coding gene. Diseases associated with CDK5 include aneurysmal bone cysts, and amyotrophic lateral sclerosis. GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and
differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell
cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1,
MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42,
TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and
NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration
and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic
plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and
CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation
loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA,
CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate
neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,
SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at
synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by
phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle
exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating
anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of
p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin
ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating
apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis
producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle
activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes
neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons
protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN
reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)
differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT
(IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional
regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA
synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex.
Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of
TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by
phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1
AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and
contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC
phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May
regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in
dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling

summary for CDK5 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK5 (Cyclin-dependent kinase 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK5 gene promoter:
         p53   p300   C/EBPalpha   PPAR-gamma1   E2F-1   E2F   HOXA5   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK5 promoter sequence
   Search Chromatin IP Primers for CDK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

CDK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150750:  view genomic region     (about GC identifiers)

Start:
150,750,899 bp from pter      End:
150,755,617 bp from pter
Size:
4,719 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,080,438-150,084,591     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5  
Size: 292 amino acids; 33304 Da
Subunit: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular
complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows
kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate
p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex
with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds
to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes.
Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1.
Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts
with PTK2/FAK1 (By similarity)
Miscellaneous: Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson,
and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis
Selected PDB 3D structures from and Proteopedia for CDK5 (see all 7):
1H4L (3D)        1LFR (3D)        1UNG (3D)        1UNH (3D)        1UNL (3D)        3O0G (3D)    
Secondary accessions: A1XKG3
Alternative splicing: 2 isoforms:  Q00535-1   Q00535-2   

Explore the universe of human proteins at neXtProt for CDK5: NX_Q00535

Explore proteomics data for CDK5 at MOPED

Post-translational modifications: 

  • Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By
    contrast, phosphorylation at Thr-14 inhibits activity1
  • Phosphorylation at Ser-159 is essential for maximal catalytic activity1
  • Ubiquitination2 at Lys20, Lys56, Lys128, Lys141, Lys268
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK5 (Q00535) (see all 20)
     WSAGCIF  LGTPTEE  VVTLWYR  LVFEFCD 


    See CDK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157882.1  NP_004926.1  

    ENSEMBL proteins: 
     ENSP00000419782   ENSP00000297518  
    Reactome Protein details: Q00535

    CDK5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK5 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CDK5
    OriGene Purified Protein for CDK5
    OriGene Protein Over-expression Lysate for CDK5
    OriGene MassSpec for CDK5
    OriGene Custom Protein Services for CDK5
    GenScript Custom Purified and Recombinant Proteins Services for CDK5
    Novus Biologicals CDK5 Proteins
    Novus Biologicals CDK5 Lysates
    Sino Biological Recombinant Protein for CDK5
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDK5
    Cloud-Clone Corp. Proteins for CDK5

     
    Search eBioscience for Proteins for CDK5 

    CDK5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK5
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDK5 
    OriGene Antibodies for CDK5
    OriGene Custom Antibody Services for CDK5
    Novus Biologicals CDK5 Antibodies
    Abcam antibodies for CDK5
    Cloud-Clone Corp. Antibodies for CDK5
    ThermoFisher Antibody for CDK5
    LSBio Antibodies in human, mouse, rat for CDK5

    CDK5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK5
    Cloud-Clone Corp. CLIAs for CDK5
    Search eBioscience for ELISAs for CDK5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 5
    CDK5 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00535

    ProtoNet protein and cluster: Q00535

    UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK5_HUMAN, Q00535
    Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and
    differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell
    cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1,
    MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42,
    TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and
    NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration
    and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic
    plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and
    CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation
    loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA,
    CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate
    neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,
    SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at
    synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by
    phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle
    exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating
    anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of
    p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin
    ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating
    apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis
    producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle
    activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes
    neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons
    protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN
    reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)
    differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT
    (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional
    regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA
    synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex.
    Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of
    TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by
    phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1
    AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and
    contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC
    phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May
    regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in
    dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine),
    1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1
    (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39)
    by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and
    induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35
    available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term
    inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity
    of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived
    neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and
    neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and
    inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents
    neurodegeneration

         Genatlas biochemistry entry for CDK5:
    cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for
    activation with its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with
    cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and
    cAMP regulated and modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant
    increase in CDK5 kinase activity,hyperphosphorylation of tau which reduces tau's ability to associate
    microtubules

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IEA--
    GO:0004672protein kinase activity TAS1639063
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004693cyclin-dependent protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with CDK5           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for CDK5:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased Salmonella enterica  
     Increased colony dispersion (i  PARP inhibitor sensitization  Wnt reporter downregulated 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cdk5):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  nervous system 
     no phenotypic analysis  normal  respiratory system 

    Find genes that share phenotypes with CDK5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDK5: Cdk5tm1Kul Cdk5tm1.2Lht

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK5:
    hsa-mir-155-5p (MIRT020734)

    Block miRNA regulation of human, mouse, rat CDK5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CDK5:
    hsa-miR-142-5p hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidCDK5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDK5
    Predesigned siRNA for gene silencing in human, mouse, rat CDK5

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410)
    Sino Biological Human cDNA Clone for CDK5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
    Addgene plasmids for CDK5 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK5_HUMAN, Q00535: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell
    projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse,
    postsynaptic cell membrane, postsynaptic density (By similarity). Note=In axonal growth cone with extension to
    the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35)
    is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level
    of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation.
    Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma
    membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane
    in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this
    attachment and activates CDK5
    CDK5_HUMAN, Q00535: Isoform 2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytoskeleton4
    cytosol4
    extracellular3
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0014069postsynaptic density ISS--

    Find genes that share ontologies with CDK5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK5 About   (see all 32)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    4Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    DARPP-32 events0.32
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58


    Find genes that share SuperPaths with CDK5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK5 (see all 8)
        Reelin Pathway (Cajal-Retzius cells)
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling
    GADD45 Pathway
    Cell Cycle Control of Chromosomal Replication

    2 Cell Signaling Technology (CST) Pathways for CDK5
        Cell Cycle / Checkpoint Control
    Neuroscience

    5 GeneGo (Thomson Reuters) Pathways for CDK5
        Neurophysiological process Receptor-mediated axon growth repulsion
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Slit-Robo signaling
    Cytoskeleton remodeling Neurofilaments
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for CDK5 (see all 10)
        DNA damage response
    Nicotine Activity on Dopaminergic Neurons
    BDNF signaling pathway
    IL-6 Signaling Pathway
    Alzheimers Disease


    3 Reactome Pathways for CDK5
        CRMPs in Sema3A signaling
    DARPP-32 events
    Factors involved in megakaryocyte development and platelet production

    1 PharmGKB Pathway for CDK5
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    3 Kegg Pathways  (Kegg details for CDK5):
        Axon guidance
    Alzheimer's disease
    Cocaine addiction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK5: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK5 (Q005351, 2, 3 ENSP000002975184) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1BP465271, 3, ENSP000002288724EBI-1041567,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    MAPTP106362, 3, ENSP000003408204MINT-3974182 I2D: score=2 STRING: ENSP00000340820
    CDK5R1Q150781, 3, ENSP000003184864EBI-1041567,EBI-746189 I2D: score=11 STRING: ENSP00000318486
    CDKN1AP389361, 3, ENSP000002447414EBI-1041567,EBI-375077 I2D: score=1 STRING: ENSP00000244741
    PPP1CAP621362, 3, ENSP000003260314MINT-8286903 I2D: score=1 STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration TAS--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0006468protein phosphorylation ----
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis ----

    Find genes that share ontologies with CDK5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK5
    Selected ApexBio Compounds for CDK5 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Compounds for CDK5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    7 DrugBank Compounds for CDK5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Indirubin-3'-Monoxime-- --targetinhibitor11752352 10592235
    6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE-- --target--10592235
    Alsterpaullone-- --target--11752352
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    Hymenialdisine-- --targetinhibitor11752352
    Olomoucine-- 101622-51-9targetinhibitor11752352
    SU9516-- --targetinhibitor11752352

    Selected Novoseek inferred chemical compound relationships for CDK5 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 92.4 97 17081516 (5), 19628755 (3), 16802322 (2), 16770643 (2) (see all 54)
    olomoucine 83.5 21 10770290 (2), 18385789 (2), 16815303 (1), 19522735 (1) (see all 10)
    butyrolactone i 75.2 6 15051507 (1), 11882652 (1), 7592534 (1), 11978846 (1)
    purvalanol 68.2 1 16611631 (1)
    glycogen 66.9 71 8627328 (2), 11805297 (2), 16818492 (2), 20211702 (2) (see all 42)
    kenpaullone 64.7 1 15950951 (1)
    threonine 63.9 52 19442718 (1), 19343042 (1), 17697781 (1), 17341134 (1) (see all 28)
    serine 55.4 57 18755796 (1), 19442718 (1), 19343042 (1), 10413323 (1) (see all 33)
    flavopiridol 51.2 2 12941380 (2)
    gamma-butyrolactone 37.3 4 15056716 (1), 18512759 (1), 15369765 (1)



    Find genes that share compounds with CDK5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CDK5 gene (2 alternative transcripts): 
    NM_001164410.1  NM_004935.3  

    Unigene Cluster for CDK5:

    Cyclin-dependent kinase 5
    Hs.647078  [show with all ESTs]
    Unigene Representative Sequence: BG577212
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485972(uc022apy.1 uc003wir.2 uc003wis.2) ENST00000297518
    ENST00000487703 ENST00000476691 ENST00000469108
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDK5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CDK5:
    hsa-miR-142-5p hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidCDK5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDK5
    Predesigned siRNA for gene silencing in human, mouse, rat CDK5
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK5 (see all 12)
    OriGene ORF clones in mouse, rat for CDK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
    Addgene plasmids for CDK5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDK5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK5
      QuantiTect SYBR Green Assays in human, mouse, rat CDK5
      QuantiFast Probe-based Assays in human, mouse, rat CDK5

    Additional mRNA sequence: 

    AK026533.1 AY049778.1 AY927560.1 BC005115.1 BT006680.1 CR457041.1 DQ411039.1 L04658.1 
    X66364.1 

    11 DOTS entries:

    DT.319808  DT.97839636  DT.121074391  DT.100022516  DT.121074369  DT.121074491  DT.95132417  DT.95372485 
    DT.95372486  DT.121074488  DT.92466216 

    Selected AceView cDNA sequences (see all 122):

    CA429180 BC005115 AI306490 BV177642 AV709223 CB144453 AA306623 BU529114 
    CF128142 AI086997 AY049778 AK026533 BE673479 AA482510 BX489021 BM727541 
    BF434699 CA431641 BT006680 N52899 NM_004935 BX112764 AA952919 BI859883 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:        -                                         -                 -                                                   
    SP2:                                                  -                 -                                                   
    SP3:        -           -                             -                 -                                                   
    SP4:                                                  -     -                                                               
    SP5:        -                                         -     -           -                                                   


    ECgene alternative splicing isoforms for CDK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCAGCCG
    CDK5 Expression
    About this image


    CDK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    CDK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647078

    UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
    Tissue specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level).
    Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK5: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDK5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK5
    QuantiTect SYBR Green Assays in human, mouse, rat CDK5
    QuantiFast Probe-based Assays in human, mouse, rat CDK5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk51 , 5 cyclin-dependent kinase 51, 5 90.87(n)1
    99.66(a)1
      5 (11.73 cM)5
    125681  NM_007668.31  NP_031694.11 
     244182505 
    chicken
    (Gallus gallus)
    Aves CDK51 cyclin-dependent kinase 5 83.56(n)
    97.26(a)
      100190948  NM_001135786.1  NP_001129258.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.672 Xenopus laevis neuronal cyclin-dependent kinase 5 (cdk5) more 81.87(n)    U24397.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk52 cyclin-dependent protein kinase 5 78.02(n)   65234  AF203736.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk51 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Cyclin-dependent kinase 51
    79(a)
    (best of 2)3
    70.72(n)1
    79.17(a)1
      2 52A133
    367271  NM_057732.31  NP_477080.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H01G02.23
    cdk-51
    serine/threonine kinase (2 domains)3
    cdk-51
    35(a)3
    64.7(n)1
    74.65(a)1
      IV(11798872-11801260)3
    1767741  NM_067382.71  NP_499783.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO851 PHO85 60.47(n)
    58.6(a)
      856076   NP_015294.1 


    ENSEMBL Gene Tree for CDK5 (if available)
    TreeFam Gene Tree for CDK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK5 gene
    CDK182  CDK142  CDK162  CDK172  CDK152  
    Selected SIMAP similar genes for CDK5 using alignment to 2 protein entries:     CDK5_HUMAN (see all proteins) (see all similar genes):
    CDK3    CDK18    CDK16    CDK17    PCTK1    CDK1
    CDC2    PCTK3    DKFZp686L20222    CDK15    CDK14    CDC2L1
    CDC2L2    CDK11A    CDK11B    CDK7    CCRK    CDK6

    Find genes that share paralogs with CDK5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CDK5
    PGOHUM00000249786


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDK5 (see all 81)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859225671,2
    C--150750511(+) CATATA/CTTTGG 2 -- int10--------
    rs125375231,2
    C,H--150750566(+) TGAGGG/AAAAGG 2 -- int13Minor allele frequency- A:0.22NA EA 242
    rs1449822501,2
    --150750961(+) AATTCA/GGGCTC 2 -- ut310--------
    rs1168631651,2
    F--150750978(+) CCCACC/TCCGGC 2 -- ut311Minor allele frequency- T:0.01EA 120
    rs92781,2
    C,F--150750980(-) CAGCCG/AGGGTG 2 -- ut31 ese311Minor allele frequency- A:0.14NA MN WA 1090
    rs20694611,2
    C,F--150750981(-) CCAGCC/TGGGGT 2 -- ut31 ese36Minor allele frequency- T:0.00NA MN 452
    rs350514461,2
    F--150751010(-) TGGTGC/TGCTGT 2 -- ut315Minor allele frequency- T:0.01MN 404
    rs796273161,2
    C--150751081(-) CCCCCA/GGCCTC 2 -- ut310--------
    rs20694601,2
    C,F--150751091(-) GGCCCC/TGGGAC 2 -- ut31 ese37Minor allele frequency- T:0.01NA MN EA 644
    rs115416021,2
    C--150751132(-) GCCCTG/TCAGCA 4 L syn12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for CDK5 (150750899 - 150755617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CDK5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7546n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv889465CNV Loss21882294
    nsv526410CNV Loss19592680
    nsv889471CNV Loss21882294
    dgv7545n71CNV Loss21882294
    nsv831188CNV Loss17160897
    nsv889476CNV Loss21882294
    nsv524928CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK5
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 123831    OMIM disorders: --

    4 diseases for CDK5:    
    About MalaCards
    aneurysmal bone cysts    amyotrophic lateral sclerosis    alzheimer's disease    neuroblastoma

    4 diseases from the University of Copenhagen DISEASES database for CDK5:
    Alzheimer's disease     Amyotrophic lateral sclerosis     Toxic encephalopathy     Lissencephaly

    Find genes that share disorders with CDK5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDK5 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 78.2 14 8870824 (2), 9666145 (1), 12719630 (1), 19154537 (1) (see all 10)
    alzheimers disease 75.3 69 9666145 (2), 18350355 (2), 16413130 (2), 15917097 (2) (see all 43)
    tauopathies 74.9 3 17113760 (2), 17908241 (1)
    paired helical filament 74.5 8 9666145 (1), 15975083 (1), 8870824 (1), 11065131 (1) (see all 5)
    neurodegeneration 71.2 40 16932754 (4), 15009631 (2), 14673208 (2), 17932412 (2) (see all 26)
    neurodegenerative diseases 71.1 66 17979810 (4), 16600851 (2), 17003520 (2), 15135890 (2) (see all 36)
    amyotrophic lateral sclerosis 57.5 22 14673208 (2), 9596352 (2), 11464850 (2), 10509378 (1) (see all 14)
    senile plaques 43.9 2 12719630 (1), 14681576 (1)
    brain diseases 42.8 3 17241267 (1), 15917097 (1)
    parkinson disease 38.6 13 9255390 (2), 20504213 (2), 19075597 (1), 7485409 (1) (see all 6)

    Genetic Association Database (GAD): CDK5
    Human Genome Epidemiology (HuGE) Navigator: CDK5 (52 documents)

    Export disorders for CDK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CDK5 gene, integrated from 10 sources (see all 643) (see top 10):
    (articles sorted by number of sources associating them with CDK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    2. Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. (PubMed id 10500146)1, 2, 9 Sharma P.... Pant H.C. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PubMed id 17591690)1, 2, 9 Lee J.-H.... Kim K.-T. (J. Cell Sci. 2007)
    4. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PubMed id 12691662)1, 2, 9 Gong X.... Mao Z. (Neuron 2003)
    5. Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. (PubMed id 18350355)1, 4, 9 Arias-VA!squez A....van Duijn C.M. (J. Neurol. 2008)
    6. Structure and regulation of the CDK5-p25(nck5a) complex. (PubMed id 11583627)1, 2, 9 Tarricone C....Musacchio A. (Mol. Cell 2001)
    7. CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. (PubMed id 20213743)1, 2, 9 Lee C.-H....Lu P.-J. (J. Cell. Biochem. 2010)
    8. Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. (PubMed id 19343042)1, 4, 9 Choi H.S....Kim Y.H. (J. Hum. Genet. 2009)
    9. No association of CDK5 genetic variants with Alzheimer's disease risk. (PubMed id 19615060)1, 4, 9 VA!zquez-Higuera J.L....Combarros O. (BMC Med. Genet. 2009)
    10. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. (PubMed id 18042622)1, 2, 9 Miyamoto Y.... Tanoue A. (J. Cell Sci. 2007)
    11. Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. (PubMed id 21465480)1, 2 Lee K.Y.... Rosales J.L. (J. Cell. Physiol. 2012)
    12. Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. (PubMed id 21415596)1, 2 Zhang J. and Herrup K. (Cell Cycle 2011)
    13. Cdk5: Mediator of neuronal development, death and the response to DNA damage. (PubMed id 21600237)1, 2 Zhu J.... Mao Z. (Mech. Ageing Dev. 2011)
    14. Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin- dependent kinase 5 dictates transcript-selective translational control. (PubMed id 21220307)1, 2 Arif A.... Fox P.L. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    15. High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. (PubMed id 21209322)1, 2 Gallazzini M....Ferraris J.D. (Mol. Biol. Cell 2011)
    16. Regulation and role of cyclin-dependent kinase activity in neuronal survival and death. (PubMed id 21044075)1, 2 Hisanaga S. and Endo R. (J. Neurochem. 2010)
    17. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
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    21. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
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    25. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    26. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    27. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. (PubMed id 18598350)1, 4 Sanghera D.K....Kamboh M.I. (BMC Med. Genet. 2008)
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    29. Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons. (PubMed id 17611284)1, 2 Anne S.L.... Humbert S. (J. Neurosci. 2007)
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    32. Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PubMed id 8275715)1, 3 Demetrick D.J....Beach D.H. (Cytogenet. Cell Genet. 1994)
    33. Cdk5 regulates the organization of Nestin and its association with p35. (PubMed id 12832492)1, 9 Sahlgren C.M....Eriksson J.E. (Mol. Cell. Biol. 2003)
    34. The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line. (PubMed id 19764350)1, 9 Kuo H.S....Lin H. (Chin J Physiol 2009)
    35. Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. (PubMed id 19822667)1, 9 Tripathi B.K. and Zelenka P.S. (Mol. Cell. Biol. 2009)
    36. Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. (PubMed id 17145757)1, 9 Lin H....Lin S.Y. (J. Biol. Chem. 2007)
    37. Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. (PubMed id 17327227)1, 9 Avraham E....Engelender S. (J. Biol. Chem. 2007)
    38. Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease. (PubMed id 18480410)1, 9 Sun K.H....Shah K. (Mol. Biol. Cell 2008)
    39. Identification of nuclear import mechanisms for the neuronal Cdk5 activator. (PubMed id 17060323)1, 9 Fu X....Qi R.Z. (J. Biol. Chem. 2006)
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    44. Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke. (PubMed id 17493033)1, 9 Mitsios N....Slevin M. (Brain Pathol. 2007)
    45. CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. (PubMed id 16327995)1, 9 Kim E....Harrison L.E. (Int. J. Oncol. 2006)
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    47. Identification of ribosomal protein L34 as a novel Cdk5 inhibitor. (PubMed id 10049762)1, 9 Moorthamer M. and Chaudhuri B. (Biochem. Biophys. Res. Commun. 1999)
    48. Identification of functional domains in the neuronal Cdk5 activator protein. (PubMed id 9038181)1, 9 Poon R.Y....Hunter T. (J. Biol. Chem. 1997)
    49. Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules. (PubMed id 18326489)1, 9 He L....Qi R.Z. (J. Biol. Chem. 2008)
    50. ODF1 phosphorylation by Cdk5/p35 enhances ODF1-OIP1 interaction. (PubMed id 17762160)1, 9 Rosales J.L....Lee K.Y. (Cell. Physiol. Biochem. 2007)
    51. Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5. (PubMed id 18076569)1, 9 Sato Y....Hisanaga S. (amp 2007)
    52. Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. (PubMed id 12226093)1, 9 Hashiguchi M....Hashiguchi T. (J. Biol. Chem. 2002)
    53. NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein. (PubMed id 11163260)1, 9 Niethammer M.... Tsai L.-H. (Neuron 2000)
    54. Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. (PubMed id 18507738)2, 9 Asada A.... Hisanaga S. (J. Neurochem. 2008)
    55. Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress. (PubMed id 18490454)1, 9 Lee J.H....Kim K.T. (J. Biol. Chem. 2008)
    56. The activation and inhibition of cyclin-dependent kinase-5 by phosphorylation. (PubMed id 17713927)1, 9 Zhang B....Tay T.E. (Biochemistry 2007)
    57. GTP-dependent secretion from neutrophils is regulated by Cdk5. (PubMed id 15492003)1, 9 Rosales J.L....Lee K.Y. (J. Biol. Chem. 2004)
    58. Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway. (PubMed id 12491158)1, 9 Peruzzi F....Amini S. (J. Neurovirol. 2002)
    59. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. (PubMed id 11784720)1, 9 Patzke H. and Tsai L.H. (J. Biol. Chem. 2002)
    60. Cloning of three novel neuronal Cdk5 activator binding proteins. (PubMed id 10721722)1, 9 Ching Y.-P.... Wang J.H. (Gene 2000)
    61. Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations. (PubMed id 20013135)1, 9 Zhang B....Tan V.B. (J Mol Model 2010)
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    64. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. (PubMed id 19363486)1, 9 Huang C....Ginsberg M.H. (Nat. Cell Biol. 2009)
    65. HIV-1 Tat inhibits NGF-induced Egr-1 transcriptional activity and consequent p35 expression in neural cells. (PubMed id 18247371)1, 9 Darbinian N....Amini S. (J. Cell. Physiol. 2008)
    66. Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. (PubMed id 18487454)1, 9 Liu R....Mao Z. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    67. Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. (PubMed id 17045592)1, 9 Sengupta A....Iqbal K. (FEBS Lett. 2006)
    68. Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics. (PubMed id 16407256)1, 9 Otyepka M....Koca J. (J. Biol. Chem. 2006)
    69. PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners. (PubMed id 17078951)1, 9 Liu F....Gong C.X. (FEBS Lett. 2006)
    70. Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. (PubMed id 16413130)1, 9 Jacobs E.H....Francis P.T. (Neuroscience 2006)
    71. Mechanism of CDK5/p25 binding by CDK inhibitors. (PubMed id 15689152)2, 9 Mapelli M.... Musacchio A. (J. Med. Chem. 2005)
    72. p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death. (PubMed id 15741232)1, 9 Hamdane M....BuAce L. (J. Cell. Sci. 2005)
    73. Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. (PubMed id 15890360)1, 9 Lacy E.R....Kriwacki R.W. (J. Mol. Biol. 2005)
    74. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. (PubMed id 16039528)2, 9 Ahn J.S.... Kosik K.S. (Chem. Biol. 2005)
    75. Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. (PubMed id 14741103)1, 9 Tanaka T....Gleeson J.G. (Neuron 2004)
    76. Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. (PubMed id 15123618)1, 9 Lin H....Wang P.S. (J. Biol. Chem. 2004)
    77. Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy. (PubMed id 11865137)1, 9 Borghi R....Tabaton M. (Neurology 2002)
    78. Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. (PubMed id 12387894)1, 9 Liu F....Gong C.X. (FEBS Lett. 2002)
    79. Molecular model of cyclin-dependent kinase 5 complexed with roscovitine. (PubMed id 12372407)1, 9 Filgueira de Azevedo W....Freitas da Silveira N.J. (Biochem. Biophys. Res. Commun. 2002)
    80. Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. (PubMed id 11389014)1, 9 Chen F. and Studzinski G.P. (Blood 2001)
    81. The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic. (PubMed id 11743029)1, 9 Paglini G....CA!ceres A. (EMBO Rep. 2001)
    82. Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. (PubMed id 10936190)1, 9 Iijima K....Suzuki T. (J. Neurochem. 2000)
    83. CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types. (PubMed id 10995546)1, 9 Jeffrey P.L.... Lin S.L. (Mol. Cell. Neurosci. 2000)
    84. Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth. (PubMed id 9822744)2, 9 Paglini G.... Caceres A. (J. Neurosci. 1998)
    85. Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. (PubMed id 9735171)1, 9 Sengupta A.... Iqbal K. (Arch. Biochem. Biophys. 1998)
    86. Interaction between Cdc37 and Cdk4 in human cells. (PubMed id 9150368)1, 9 Lamphere L.... Gyuris J. (Oncogene 1997)
    87. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. (PubMed id 9244350)1, 9 Wang H....Rao V.N. (Oncogene 1997)
    88. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. (PubMed id 9030781)2, 9 Meijer L.... Moulinoux J.-P. (Eur. J. Biochem. 1997)
    89. Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes. (PubMed id 7949095)1, 9 Szepesi A....Lucas J.J. (Blood 1994)
    90. Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. (PubMed id 24235147)1 Kwak Y....Park S.K. (J. Biol. Chem. 2013)
    91. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. (PubMed id 23362255)1 Kimura T....Hisanaga S. (J. Biol. Chem. 2013)
    92. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    93. Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments. (PubMed id 23728742)1 Holmgren A....Timmerman V. (Acta Neuropathol. 2013)
    94. 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. (PubMed id 23332172)1 Chu J. and PraticA^ D. (Neurobiol. Aging 2013)
    95. Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. (PubMed id 24085300)1 Saito T....Hisanaga S. (J. Biol. Chem. 2013)
    96. The role of Cdk5 in neuroendocrine thyroid cancer. (PubMed id 24135281)1 Pozo K....Bibb J.A. (Cancer Cell 2013)
    97. Cyclin-dependent kinase 5 promotes the stability of corneal epithelial cell junctions. (PubMed id 23401660)1 Arpitha P....Zelenka P. (Mol. Vis. 2013)
    98. Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Sera8^A^a8^ on STAT3 in prostate cancer cells. (PubMed id 23941877)1 Hsu F.N....Lin H. (Am. J. Physiol. Endocrinol. Metab. 2013)
    99. Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications. (PubMed id 22964075)1 Ramos-Miguel A....GarcA-a-Sevilla J.A. (Int. J. Neuropsychopharmacol. 2013)
    100. Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity. (PubMed id 23543736)1 Kabuta T....Wada K. (J. Biol. Chem. 2013)
    101. EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells. (PubMed id 24091658)1 Rea K....Tomassetti A. (amp 2013)
    102. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    103. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. (PubMed id 22753194)1 Bai B....Wang Y. (Circulation 2012)
    104. Association of rs2069459 in the CDK5 gene with dyslexia in a German cohort. (PubMed id 22547140)1 Burkhardt J....Wilcke A. (Psychiatr. Genet. 2012)
    105. Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function. (PubMed id 22829587)1 Filippova N....Nabors L.B. (J. Biol. Chem. 2012)
    106. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    107. Cyclin-dependent kinase 5 in axon growth and regeneration. (PubMed id 23206597)1 Ye T....Ip N.Y. (Int. Rev. Neurobiol. 2012)
    108. Going out of the brain: non-nervous system physiological and pathological functions of Cdk5. (PubMed id 21924349)1 Contreras-Vallejos E....Gonzalez-Billault C. (Cell. Signal. 2012)
    109. The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation. (PubMed id 21922195)1 Bolin C....Hall J. (Cell. Mol. Life Sci. 2012)
    110. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    111. Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway. (PubMed id 22696682)1 Demelash A....Linnoila R.I. (Mol. Biol. Cell 2012)
    112. S-nitrosylation of Cdk5: potential implications in amyloid-I^-related neurotoxicity in Alzheimer disease. (PubMed id 22874667)1 Qu J....Lipton S.A. (Prion 2012)
    113. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. (PubMed id 22654103)1 Zhang J....Herrup K. (J. Biol. Chem. 2012)
    114. Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin. (PubMed id 22778260)1 Kuhse J....Kirsch J. (J. Biol. Chem. 2012)
    115. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    116. Association between plasma biomarkers, CDK5 polymorphism and the risk of Alzheimer's disease. (PubMed id 23377270)1 Czapski G.A....Strosznajder J.B. (Acta Neurobiol Exp (Wars) 2012)
    117. Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death. (PubMed id 22899714)1 Chang K.H....Shah K. (J. Cell. Sci. 2012)
    118. Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development. (PubMed id 22768111)1 Terabayashi T....Nishinakamura R. (PLoS ONE 2012)
    119. Cdk5 protein inhibition and AI^42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease. (PubMed id 22223639)1 Sadleir K.R. and Vassar R. (J. Biol. Chem. 2012)
    120. Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons. (PubMed id 22833568)1 Modi P.K....Sharma P. (Mol. Biol. Cell 2012)
    121. Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function. (PubMed id 21701498)1 Fitzgerald J.C....Plun-Favreau H. (Cell Death Differ. 2012)
    122. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. (PubMed id 21435449)1 Patrick C....Masliah E. (Am. J. Pathol. 2011)
    123. Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease. (PubMed id 21499257)2 Wong A.S....Ip N.Y. (Nat. Cell Biol. 2011)
    124. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    125. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    126. Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis. (PubMed id 20354813)1 Liu J.L....Wu G. (Med. Oncol. 2011)
    127. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. (PubMed id 21844361)1 Qu J....Lipton S.A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    128. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. (PubMed id 21668448)2 Sun K.H....Shah K. (J. Neurochem. 2011)
    129. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    130. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    131. Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-I^ prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes. (PubMed id 21671254)1 Maldonado H....Valenzuela M.A. (J. Neurosci. Res. 2011)
    132. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    133. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    134. Cdk5: multitasking between physiological and pathological conditions. (PubMed id 21473899)2 Lopes J.P. and Agostinho P. (Prog. Neurobiol. 2011)
    135. c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. (PubMed id 19700222)1 Cancino G.I....Alvarez A.R. (Neurobiol. Aging 2011)
    136. Regulation of androgen receptor and prostate cancer growth by cyclin-dependent kinase 5. (PubMed id 21799006)1 Hsu F.N....Lin H. (J. Biol. Chem. 2011)
    137. Pathogenic role of the X-linked cyclin-dependent kinase-like 5 and aristaless-related homeobox genes in epileptic encephalopathy of unknown etiology with onset in the first year of life. (PubMed id 21482751)1 Sartori S....Murgia A. (J. Child Neurol. 2011)
    138. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    139. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PubMed id 21163940)1 Soler-LA^pez M....Aloy P. (Genome Res. 2011)
    140. Twice switched at birth: cell cycle-independent roles of the &quot;neuron-specific&quot; cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells. (PubMed id 21741478)1 Liebl J....Zahler S. (Cell. Signal. 2011)
    141. Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5. (PubMed id 21712386)1 Cerda O. and Trimmer J.S. (J. Biol. Chem. 2011)
    142. Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25. (PubMed id 21144757)2 Jain P.... Madura J.D. (Bioorg. Med. Chem. 2011)
    143. Adipocyte NCoR knockout decreases PPARI^ phosphorylation and enhances PPARI^ activity and insulin sensitivity. (PubMed id 22078880)1 Li P....Olefsky J.M. (Cell 2011)
    144. RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5. (PubMed id 21289309)1 Zhu Y.X....Stewart A.K. (Blood 2011)
    145. Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. (PubMed id 21825040)1 Eggers J.P....Hollingsworth M.A. (Clin. Cancer Res. 2011)
    146. Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development. (PubMed id 21335063)1 Fu W.Y....Ip N.Y. (Neuroscience 2011)
    147. Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75). (PubMed id 21442427)2 Pan Q.... Zelenka P.S. (Cell. Mol. Life Sci. 2011)
    148. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    149. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. (PubMed id 21145489)1 Lowman X.H....Kelekar A. (Mol. Cell 2010)
    150. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. (PubMed id 20651683)1 Choi J.H....Spiegelman B.M. (Nature 2010)
    151. Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation. (PubMed id 20234188)1 Rosales J.L....Lee K.Y. (Cell Cycle 2010)
    152. A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. (PubMed id 20720012)1 Zheng Y.L....Pant H.C. (J. Biol. Chem. 2010)
    153. Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. (PubMed id 20673369)1 Ajay A.K....Bhat M.K. (Mol. Cancer 2010)
    154. The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation. (PubMed id 19960242)1 Nair A....Nistri A. (Cell. Mol. Neurobiol. 2010)
    155. No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. (PubMed id 20133653)1 Peterson D.W....Lew J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    156. The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition. (PubMed id 20516069)1 Courapied S....Coqueret O. (J. Biol. Chem. 2010)
    157. Kinetic mechanistic studies of Cdk5/p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect. (PubMed id 20491486)1 Liu M....Stein R.L. (Biochemistry 2010)
    158. Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease. (PubMed id 20345761)1 Chang K.H....Shah K. (J. Neurochem. 2010)
    159. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    160. Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor. (PubMed id 20357208)1 Kino T....Pant H.C. (Mol. Endocrinol. 2010)
    161. Cdk5, the multifunctional surveyor. (PubMed id 20061803)2 Lalioti V.... Sandoval I.V. (Cell Cycle 2010)
    162. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    163. Cell cycle, CDKs and cancer: a changing paradigm. (PubMed id 19238148)2 Malumbres M. and Barbacid M. (Nat. Rev. Cancer 2009)
    164. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    165. [Functions of Cdk5 in non-neuronal tissues: focusing on regulation of insulin secretion]. (PubMed id 19514266)1 Tomizawa K. (Tanpakushitsu Kakusan Koso 2009)
    166. Making a neuron: Cdk5 in embryonic and adult neurogenesis. (PubMed id 19782409)2 Jessberger S.... Lagace D.C. (Trends Neurosci. 2009)
    167. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    168. Combined kinase inhibition modulates parkin inactivation. (PubMed id 19050041)1 Rubio de la Torre E....Hilfiker S. (Hum. Mol. Genet. 2009)
    169. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    170. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    171. Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1. (PubMed id 18408012)1 Seo H.R....Lee Y.S. (J. Biol. Chem. 2008)
    172. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    173. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. (PubMed id 19081376)2 Kim D.... Tsai L.H. (Neuron 2008)
    174. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. (PubMed id 18460467)1 Cole A.R....Sutherland C. (J. Biol. Chem. 2008)
    175. cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells. (PubMed id 17009320)2 Munoz J.P.... Maccioni R.B. (J. Cell. Biochem. 2007)
    176. Microtubule association of the neuronal p35 activator of Cdk5. (PubMed id 17491008)1 Hou Z....Qi R.Z. (J. Biol. Chem. 2007)
    177. Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis. (PubMed id 17419807)1 Liang S....Takei K. (J. Neurochem. 2007)
    178. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    179. Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling. (PubMed id 17581253)1 Chen T.C....Juang J.L. (Cell. Microbiol. 2007)
    180. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. (PubMed id 17143272)2 Fu W.Y.... Ip N.Y. (Nat. Neurosci. 2007)
    181. Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis. (PubMed id 17290217)1 Nakano-Kobayashi A....Kanaho Y. (EMBO J. 2007)
    182. Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35. (PubMed id 17671990)2 Sato K....Hisanaga S. (J. Neurosci. Res. 2007)
    183. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. (PubMed id 17906618)1 Plun-Favreau H....Downward J. (Nat. Cell Biol. 2007)
    184. Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta. (PubMed id 16519508)1 Li T....Paudel H.K. (Biochemistry 2006)
    185. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. (PubMed id 17036052)1 Sahlgren C.M....Eriksson J.E. (EMBO J. 2006)
    186. Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. (PubMed id 16356933)1 Gregoire S.... Yang X.-J. (J. Biol. Chem. 2006)
    187. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. (PubMed id 16862120)1 Kim Y....Greengard P. (Nature 2006)
    188. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    189. Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation. (PubMed id 15834155)1 Solomaha E....Palfrey H.C. (J. Biol. Chem. 2005)
    190. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (Science 2005)
    191. Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. (PubMed id 15911879)1 Luo S....Rubinsztein D.C. (J. Cell Biol. 2005)
    192. Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation. (PubMed id 15992363)2 Zhu Y.-S.... Hisanaga S. (J. Neurochem. 2005)
    193. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. (PubMed id 15652488)1 Yoshimura T....Kaibuchi K. (Cell 2005)
    194. Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins. (PubMed id 12963086)1 Bhaskar K....Shetty K.T. (Neurochem. Int. 2004)
    195. The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis. (PubMed id 15030318)1 Bukczynska P....Tiganis T. (Biochem. J. 2004)
    196. Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. (PubMed id 15013773)1 Qi R.Z....Wang J.H. (FEBS Lett. 2004)
    197. Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)1 Ballif B.A....Gygi S.P. (amp 2004)
    198. Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. (PubMed id 14704270)1 Lee S.Y....De Camilli P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    199. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. (PubMed id 15489224)1 Li Z....Ip N.Y. (J. Biol. Chem. 2004)
    200. Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation. (PubMed id 15178331)1 Taru H....Suzuki T. (FEBS Lett. 2004)
    201. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    202. Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex. (PubMed id 12826674)1 Hamdane M....BuAce L. (J. Biol. Chem. 2003)
    203. Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. (PubMed id 12972605)1 Khalili K....Gordon J. (Mol. Cell. Biol. 2003)
    204. Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. (PubMed id 12824184)1 Li B.S....Pant H.C. (J. Biol. Chem. 2003)
    205. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
    206. Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase. (PubMed id 12832520)1 Kesavapany S....Miller C.C. (J. Neurosci. 2003)
    207. Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. (PubMed id 12769842)1 Yang H.S. and Hinds P.W. (Mol. Cell 2003)
    208. Cdk5 is essential for synaptic vesicle endocytosis. (PubMed id 12855954)1 Tan T.C....Robinson P.J. (Nat. Cell Biol. 2003)
    209. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. (PubMed id 12765608)1 Noble W....Duff K. (Neuron 2003)
    210. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    211. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. (PubMed id 12796778)1 Toyo-oka K....Wynshaw-Boris A. (Nat. Genet. 2003)
    212. Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7. (PubMed id 12970441)1 He W....Fisher C. (J. Virol. 2003)
    213. Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability. (PubMed id 12056836)1 Lau K.F....Miller C.C. (Mol. Cell. Neurosci. 2002)
    214. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. (PubMed id 12071639)1 Augustinack J.C....Hyman B.T. (J. Neuropathol. Exp. Neurol. 2002)
    215. A novel centrosome-associated protein with affinity for microtubules. (PubMed id 12154070)1 Stein P.A.... Rapoport T.A. (J. Cell Sci. 2002)
    216. The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. (PubMed id 11741927)1 Qu D....Qi R.Z. (J. Biol. Chem. 2002)
    217. Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35. (PubMed id 12393264)2 Kerokoski P.... Pirttilae T. (Brain Res. Mol. Brain Res. 2002)
    218. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. (PubMed id 12223541)1 Dhavan R....Tsai L.H. (J. Neurosci. 2002)
    219. Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. (PubMed id 12077184)1 Keshvara L....Curran T. (J. Neurosci. 2002)
    220. TTD: Therapeutic Target Database. (PubMed id 11752352)7 Chen X....Chen Y.Z. (Nucleic Acids Res. 2002)
    221. Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5. (PubMed id 12435421)1 Liu F....Gong C.X. (Neuroscience 2002)
    222. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    223. ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. (PubMed id 11955625)1 Sato H....Matsuoka M. (Biochim. Biophys. Acta 2002)
    224. Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. (PubMed id 11823425)1 Li B.S....Pant H.C. (EMBO J. 2002)
    225. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. (PubMed id 12372285)1 Sasaki Y....Goshima Y. (Neuron 2002)
    226. Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. (PubMed id 11882646)1 Ching Y.-P.... Wang J.H. (J. Biol. Chem. 2002)
    227. Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. (PubMed id 12084709)1 Cheng K....Ip N.Y. (J. Biol. Chem. 2002)
    228. Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. (PubMed id 11684694)1 Sharma P....Pant H.C. (J. Biol. Chem. 2002)
    229. Cdk5 phosphorylates p53 and regulates its activity. (PubMed id 12064478)1 Zhang J....Johnson G.V. (J. Neurochem. 2002)
    230. Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. (PubMed id 11113134)1 Floyd S.R....De Camilli P. (J. Biol. Chem. 2001)
    231. Regulation of NMDA receptors by cyclin-dependent kinase-5. (PubMed id 11675505)1 Li B.S....Pant H.C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    232. Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity. (PubMed id 11483158)1 Turenne G.A. and Price B.D. (BMC Cell Biol. 2001)
    233. Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. (PubMed id 11320080)1 Agarwal-Mawal A. and Paudel H.K. (J. Biol. Chem. 2001)
    234. p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction. (PubMed id 11168528)1 Kesavapany S....Miller C.C. (Eur. J. Neurosci. 2001)
    235. Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. (PubMed id 11278541)1 Sahlgren C.M....Eriksson J.E. (J. Biol. Chem. 2001)
    236. Phosphorylation of tau is regulated by PKN. (PubMed id 11104762)1 Taniguchi T....Tanaka C. (J. Biol. Chem. 2001)
    237. The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3- priming kinase. (PubMed id 11311121)1 Woods Y.L....Proud C.G. (Biochem. J. 2001)
    238. A decade of CDK5. (PubMed id 11584302)2 Dhavan R. and Tsai L.H. (Nat. Rev. Mol. Cell Biol. 2001)
    239. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)1 Yamochi T....Matsuoka M. (Eur. J. Biochem. 2001)
    240. Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease. (PubMed id 11516829)1 Vincent I....Jin L. (Neuroscience 2001)
    241. Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation. (PubMed id 11254741)1 Takasaki Y....Hashimoto H. (J. Immunol. 2001)
    242. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. (PubMed id 11604394)1 Rashid T....Nikolic M. (J. Biol. Chem. 2001)
    243. Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry. (PubMed id 11181841)1 Lund E.T....Mathews W.R. (J. Neurochem. 2001)
    244. The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. (PubMed id 10884347)1 Luciani M.G.... Hupp T.R. (J. Mol. Biol. 2000)
    245. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    246. Identification of a common protein association region in the neuronal Cdk5 activator. (PubMed id 10915792)1 Wang X....Wang J.H. (J. Biol. Chem. 2000)
    247. Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. (PubMed id 10762698)1 Veeranna ....Veeranna G.J. (Brain Res. Mol. Brain Res. 2000)
    248. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. (PubMed id 10683146)1 Humbert S....Tsai L. (J. Cell. Sci. 2000)
    249. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. (PubMed id 10604473)1 Bibb J.A.... Greengard P. (Nature 1999)
    250. Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells. (PubMed id 10544291)1 Kato G. and Maeda S. (J. Biochem. 1999)
    251. New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. (PubMed id 9832145)1 Hanger D.P....Anderton B.H. (J. Neurochem. 1998)
    252. Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells. (PubMed id 9565682)1 Michel G....Takashima A. (Biochim. Biophys. Acta 1998)
    253. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. (PubMed id 9546672)1 Zheng-FischhAPfer Q....Mandelkow E. (Eur. J. Biochem. 1998)
    254. Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins. (PubMed id 9545286)1 Wu S.M....Lee M.Y. (J. Biol. Chem. 1998)
    255. Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings. (PubMed id 9478941)1 Shuang R....Stuenkel E.L. (J. Biol. Chem. 1998)
    256. The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. (PubMed id 9614189)1 Illenberger S.... Mandelkow E. (Mol. Biol. Cell 1998)
    257. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. (PubMed id 9771888)1 Wang J.Z....Iqbal K. (FEBS Lett. 1998)
    258. Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity. (PubMed id 9422379)1 Guidato S....Miller C.C. (J. Neurochem. 1998)
    259. Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro. (PubMed id 9353289)1 Paudel H.K. (J. Biol. Chem. 1997)
    260. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. (PubMed id 9199504)1 Goedert M....Cohen P. (FEBS Lett. 1997)
    261. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. (PubMed id 9013862)1 Kanaoka Y....Nojima H. (FEBS Lett. 1997)
    262. Identification of DNA replication and cell cycle proteins that interact with PCNA. (PubMed id 9396813)1 Loor G....Lee M.Y. (Nucleic Acids Res. 1997)
    263. Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions. (PubMed id 8702879)1 Matsubara M....Taniguchi H. (J. Biol. Chem. 1996)
    264. Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm. (PubMed id 8891282)1 Ino H. and Chiba T. (Brain Res. 1996)
    265. In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta. (PubMed id 8764598)1 Aplin A.E....Anderton B.H. (J. Neurochem. 1996)
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    269. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]. (PubMed id 1330687)1 Goedert M....Cohen P. (FEBS Lett. 1992)
    270. Proceedings: Aneurysmal bone cysts of the spine. (PubMed id 1181841)1 Ameli N.O....Slamdoost A. (Acta Neurochir (Wien) 1975)
    271. Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. (PubMed id 19812325)9 Rashidian J....Park D.S. (J. Neurosci. 2009)
    272. Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. (PubMed id 14627648)9 Hallows J.L....Vincent I. (J. Neurosci. 2003)
    273. Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction. (PubMed id 18691386)9 Sun K.H....Shah K. (J. Neurochem. 2008)
    274. Cyclin-dependent kinase 5 (Cdk5): a potential therapeutic target for the treatment of neurodegenerative diseases and diabetes mellitus. (PubMed id 17979810)9 Wei F.Y. and Tomizawa K. (Mini Rev Med Chem 2007)
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    276. Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. (PubMed id 16887799)9 Ubeda M....Habener J.F. (J. Biol. Chem. 2006)
    277. Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5. (PubMed id 15273248)9 Barclay J.W....Burgoyne R.D. (J. Biol. Chem. 2004)
    278. The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology. (PubMed id 11248668)9 Maccioni R.B....MuA+oz J.P. (Eur. J. Biochem. 2001)
    279. Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. (PubMed id 18463240)9 Cheung Z.H....Ip N.Y. (J. Neurosci. 2008)
    280. The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte. (PubMed id 17295212)9 He Y....Wang Y. (Glia 2007)
    281. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist. (PubMed id 16879821)9 Wang Y....Wang Y. (Exp. Neurol. 2006)
    282. Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide. (PubMed id 15023357)9 Kesavapany S....Pant H.C. (Biochim. Biophys. Acta 2004)
    283. Cdk5 in the adult non-demented brain. (PubMed id 14683465)9 Fischer A....Radulovic J. (Curr Drug Targets CNS Neurol Disord 2003)
    284. Cyclin-dependent kinase 5 is expressed in both Sertoli cells and metaphase spermatocytes. (PubMed id 11287016)9 Session D.R....Wieben E.D. (Fertil. Steril. 2001)
    285. Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock. (PubMed id 11228158)9 Gao C....Zelenka P. (J. Cell. Sci. 2001)
    286. Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening. (PubMed id 19534817)9 JAomsAo A....VasAonge M. (J. Biomed. Sci. 2009)
    287. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. (PubMed id 18701695)9 Miyamoto Y....Tanoue A. (J. Neurosci. 2008)
    288. Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5. (PubMed id 17081516)9 Goodyear S. and Sharma M.C. (Exp. Mol. Pathol. 2007)
    289. Cyclin-dependent kinase 5 links extracellular cues to actin cytoskeleton during dendritic spine development. (PubMed id 19270534)9 Fu A.K. and Ip N.Y. (amp 2007)
    290. Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. (PubMed id 17178437)9 Kanungo J....Pant H.C. (Neurosci. Lett. 2007)
    291. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. (PubMed id 17341134)9 Cheung Z.H....Ip N.Y. (PLoS Biol. 2007)
    292. Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells. (PubMed id 15485494)9 Lee J.H. and Kim K.T. (J. Neurochem. 2004)
    293. Activation of cyclin-dependent kinase 5 is involved in axonal regeneration. (PubMed id 15033170)9 Namgung U....Kim K.T. (Mol. Cell. Neurosci. 2004)
    294. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. (PubMed id 15194121)9 Cruz J.C. and Tsai L.H. (Curr. Opin. Neurobiol. 2004)
    295. Cyclin-dependent kinase 5 promotes insulin exocytosis. (PubMed id 11443123)9 Lilja L....Bark C. (J. Biol. Chem. 2001)
    296. Effect of cdk5 antagonist on L-dopa-induced dyskinesias in a rat model of Parkinson's disease. (PubMed id 20504213)9 Guan Q....Zhao L. (Int. J. Neurosci. 2010)
    297. Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons. (PubMed id 18550843)9 Zhang J....Herrup K. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    298. Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5. (PubMed id 18829967)9 Paoletti P....GinAcs S. (J. Neurosci. 2008)
    299. New approaches to the discovery of cdk5 inhibitors. (PubMed id 18220519)9 Glicksman M.A....Kosik K.S. (Curr Alzheimer Res 2007)
    300. Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. (PubMed id 16885348)9 Strock C.J....Nelkin B.D. (Cancer Res. 2006)
    301. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. (PubMed id 15888658)9 Tang X.... Mao Z. (J. Neurosci. 2005)
    302. Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. (PubMed id 15466384)9 Griffin S.V....Shankland S.J. (Am. J. Pathol. 2004)
    303. Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease. (PubMed id 15975083)9 Monaco E.A. (Curr Alzheimer Res 2004)
    304. Role of cdk5 in the pathogenesis of Alzheimer's disease. (PubMed id 14673207)9 Lau L.F. and Ahlijanian M.K. (Neurosignals 2003)
    305. Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. (PubMed id 12200628)9 Becker A.J....BlA1mcke I. (Acta Neuropathol. 2002)
    306. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. (PubMed id 9727024)9 Patrick G.N....Tsai L.H. (J. Biol. Chem. 1998)
    307. Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration. (PubMed id 9666145)9 Pei J.J....Cowburn R.F. (Brain Res. 1998)
    308. Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. (PubMed id 19628755)9 Price D.A....Zahniser N.R. (Mol. Pharmacol. 2009)
    309. Activation of cyclin-dependent kinase 5 is a consequence of cell death. (PubMed id 19830249)9 Ye Y....Zakeri Z. (amp 2009)
    310. The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5. (PubMed id 19522735)9 Chen P.C....Chen J.C. (J. Neurochem. 2009)
    311. Cyclin-dependent kinase 5 regulates steroidogenic acute regulatory protein and androgen production in mouse Leydig cells. (PubMed id 18755796)9 Lin H....Ku C.T. (Endocrinology 2009)
    312. N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons. (PubMed id 18512759)9 Hsiao Y.H....Gean P.W. (J. Neurosci. Res. 2008)
    313. Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. (PubMed id 19075597)9 Upadhyay A.K....Bhat M.K. (Curr Cancer Drug Targets 2008)
    314. [Ginsenoside Rb1 attenuates beta-amyloid peptide(25-35) -induced hyperphosphorylation of tau protein through CDK5 signal pathway]. (PubMed id 17944229)9 Xie Y.H....Lin Z.Y. (Yao Xue Xue Bao 2007)
    315. Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. (PubMed id 16678793)9 JAomsAo A....VasAonge M. (Biochem. Biophys. Res. Commun. 2006)
    316. Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. (PubMed id 15712243)9 Gillardon F....Gerner C. (Proteomics 2005)
    317. CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. (PubMed id 16029324)9 Nakano N....Ogawa H. (Br. J. Dermatol. 2005)
    318. Role of cyclin-dependent kinase 5 and its activator P35 in local axon and growth cone stabilization. (PubMed id 15964697)9 Hahn C.M....Pollerberg G.E. (Neuroscience 2005)
    319. Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells. (PubMed id 15048935)9 Shelton S.B....Johnson G.V. (J. Neurosci. Res. 2004)
    320. Specific association of increased cyclin-dependent kinase 5 expression with monocytic lineage of differentiation of human leukemia HL60 cells. (PubMed id 10770290)9 Chen F....Studzinski G.P. (J. Leukoc. Biol. 2000)
    321. Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis. (PubMed id 11464850)9 Bajaj N.P. (Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2000)
    322. Cyclin-dependent kinase 5 activity enhances monocytic phenotype and cell cycle traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells. (PubMed id 10366442)9 Chen F. and Studzinski G.P. (Exp. Cell Res. 1999)
    323. Identification of a human cDNA encoding a kinase-defective cdk5 isoform. (PubMed id 9878533)9 Moorthamer M....Chaudhuri B. (Biochem. Biophys. Res. Commun. 1998)
    324. Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5. (PubMed id 9378721)9 Ando S....Inagaki M. (J. Biochem. 1997)
    325. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. (PubMed id 7485409)9 Brion J.P. and Couck A.M. (Am. J. Pathol. 1995)
    326. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. (PubMed id 8306873)9 Tsai L.H....Harlow E. (Development 1993)
    327. Recent advances in understanding the roles of Cdk5 in synaptic plasticity. (PubMed id 19442718)9 Lai K.O. and Ip N.Y. (Biochim. Biophys. Acta 2009)
    328. Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission. (PubMed id 19263480)9 Kissler A.E....Suter B. (Dev Neurobiol 2009)
    329. Extraneuronal roles of cyclin-dependent kinase 5. (PubMed id 16998837)9 Rosales J.L. and Lee K.Y. (Bioessays 2006)
    330. Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors. (PubMed id 17003520)9 Schmid G....Wesierska-Gadek J. (Mol. Neurobiol. 2006)
    331. Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. (PubMed id 17029592)9 Angelo M....Giese K.P. (J. Neurochem. 2006)
    332. Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. (PubMed id 16192386)9 O'Hare M.J....Park D.S. (J. Neurosci. 2005)
    333. Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses. (PubMed id 15908038)9 Johansson J.U....Bark C. (Brain Res. Mol. Brain Res. 2005)
    334. Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. (PubMed id 16237170)9 Cicero S. and Herrup K. (J. Neurosci. 2005)
    335. Cellular senescence requires CDK5 repression of Rac1 activity. (PubMed id 15024070)9 Alexander K....Hinds P.W. (Mol. Cell. Biol. 2004)
    336. Cyclin-dependent kinase-5 in neurodegeneration. (PubMed id 15009631)9 Shelton S.B. and Johnson G.V. (J. Neurochem. 2004)
    337. Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5. (PubMed id 15099191)9 Graham M.E....Jeffrey P.L. (Biochem. J. 2004)
    338. L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway. (PubMed id 15208659)9 Sarker K.P. and Lee K.Y. (Oncogene 2004)
    339. Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress. (PubMed id 15160391)9 Shea T.B....Pant H.C. (J. Neurosci. Res. 2004)
    340. Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. (PubMed id 15123626)9 Lilja L....Bark C. (J. Biol. Chem. 2004)
    341. The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator. (PubMed id 14673209)9 Hisanaga S. and Saito T. (Neurosignals 2003)
    342. Protein-protein interactions in Cdk5 regulation and function. (PubMed id 14673210)9 Lim A.C....Qi R.Z. (Neurosignals 2003)
    343. Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells. (PubMed id 11296485)9 Catania A....Allalunis-Turner J. (Neuro-oncology 2001)
    344. Cyclin-dependent kinase 5 colocalizes with phosphorylated tau in human inclusion-body myositis paired-helical filaments and may play a role in tau phosphorylation. (PubMed id 11065131)9 Wilczynski G.M....Askanas V. (Neurosci. Lett. 2000)
    345. CDK-5-mediated neurofilament phosphorylation in SHSY5Y human neuroblastoma cells. (PubMed id 10386957)9 Sharma M....Pant H.C. (J. Neurochem. 1999)
    346. Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5). (PubMed id 9313898)9 Pant A.C....Amin N. (Brain Res. 1997)
    347. Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons. (PubMed id 9044056)9 Pigino G....CA!ceres A. (J. Cell. Sci. 1997)
    348. Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5. (PubMed id 8627328)9 Guidato S....Miller C.C. (J. Neurochem. 1996)
    349. p35 is required for CDK5 activation in cellular senescence. (PubMed id 20181942)9 Mao D. and Hinds P.W. (J. Biol. Chem. 2010)
    350. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. (PubMed id 18054859)9 Samuels B.A....Tsai L.H. (Neuron 2007)
    351. Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases. (PubMed id 16600851)9 Cheung Z.H....Ip N.Y. (Neuron 2006)
    352. Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. (PubMed id 15994305)9 Sakaue F....Hisanaga S. (J. Biol. Chem. 2005)
    353. Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. (PubMed id 14720205)9 Liu T....Atwood C.S. (J. Neurochem. 2004)
    354. The structural perspective on CDK5. (PubMed id 14673202)9 Mapelli M. and Musacchio A. (Neurosignals 2003)
    355. Cyclin-dependent kinase 5--a neuronal killer? (PubMed id 14681576)9 Guo Q. (Sci Aging Knowledge Environ 2003)
    356. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. (PubMed id 14673203)9 Gupta A. and Tsai L.H. (Neurosignals 2003)
    357. Cyclin-dependent kinase 5 is required for associative learning. (PubMed id 11978846)9 Fischer A....Radulovic J. (J. Neurosci. 2002)
    358. Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5. (PubMed id 9059986)9 Sengupta A....Singh T.J. (Mol. Cell. Biochem. 1997)
    359. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. (PubMed id 9192869)9 Philpott A....Tsai L.H. (amp 1997)
    360. p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease. (PubMed id 9255390)9 Nakamura S....Kimura J. (Acta Neuropathol. 1997)
    361. Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid rafts. (PubMed id 19158430)9 Hernandez P....Maccioni R.B. (J. Alzheimers Dis. 2009)
    362. The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface. (PubMed id 19326393)9 MuruA!is G....Sandoval I.V. (J. Cell. Physiol. 2009)
    363. The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes. (PubMed id 19255425)9 Lalioti V....Sandoval I.V. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    364. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. (PubMed id 19017804)9 Meyer D.A....Bibb J.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    365. Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment. (PubMed id 17006763)9 Sultana R. and Butterfield D.A. (Neurochem. Res. 2007)
    366. Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. (PubMed id 17400554)9 Nguyen C....Bibb J.A. (J. Biol. Chem. 2007)
    367. MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25, and JNK. (PubMed id 15845356)9 Kawauchi T....Hoshino M. (Biochem. Biophys. Res. Commun. 2005)
    368. Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase. (PubMed id 15342635)9 Lim A.C....Qi R.Z. (J. Biol. Chem. 2004)
    369. The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells. (PubMed id 12688339)9 Studzinski G.P. and Harrison J.S. (amp 2003)
    370. [Importance of reelin in the development of the central nervous system. II. Cyclin-dependent kinase 5 as an important element in the reelin signalling cascade]. (PubMed id 12693185)9 VeselA1 J....CervenkovA! K. (Cesk Fysiol 2003)
    371. Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice. (PubMed id 11932941)9 Bian F....Walker L.C. (J. Comp. Neurol. 2002)
    372. Involvement of cyclin-dependent kinases in axotomy-induced retinal ganglion cell death. (PubMed id 11967896)9 LefA"vre K....CastagnAc V. (J. Comp. Neurol. 2002)
    373. Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice. (PubMed id 11162238)9 Van den Haute C....Van Leuven F. (Neurobiol. Dis. 2001)
    374. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. (PubMed id 11276227)9 Fu A.K....Ip N.Y. (Nat. Neurosci. 2001)
    375. Aberrant expression of cyclin-dependent kinase 5 in inclusion body myositis. (PubMed id 10563611)9 Nakano S....Kimura J. (Neurology 1999)
    376. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. (PubMed id 10604467)9 Patrick G.N....Tsai L.H. (Nature 1999)
    377. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. (PubMed id 8846918)9 Nikolic M....Tsai L.H. (amp 1996)
    378. Glucocorticoid regulation of G1 cyclin-dependent kinase genes in lymphoid cells. (PubMed id 7669723)9 Rhee K....Thompson E.A. (amp 1995)
    379. Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells. (PubMed id 19944738)9 Choi H.S. and Chung S.H. (Neurosci. Lett. 2010)
    380. Glycogen synthase kinase-3beta and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons. (PubMed id 20211702)9 Morel M....Brion J.P. (Neuroscience 2010)
    381. Increased CRMP2 phosphorylation is observed in Alzheimer's disease; does this tell us anything about disease development? (PubMed id 19519308)9 Soutar M.P....Sutherland C. (Curr Alzheimer Res 2009)
    382. The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo. (PubMed id 18385789)9 Tripathi B.K....Zelenka P.S. (Mol. Vis. 2008)
    383. Overexpression of Cdk5 or non-phosphorylatable retinoblastoma protein protects septal neurons from oxygen-glucose deprivation. (PubMed id 18351461)9 Panickar K.S....Barrett J.N. (Neurochem. Res. 2008)
    384. Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain. (PubMed id 18588979)9 Sallam H....Hassan M. (Pharmacol. Res. 2008)
    385. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. (PubMed id 18325333)9 Lin S....Lin S.C. (FEBS Lett. 2008)
    386. Inhibition of cyclin-dependent kinase 5 by roscovitine impairs memory consolidation and reconsolidation in the day-old chick. (PubMed id 18627776)9 Sherry J.M. and Crowe S.F. (Pharmacol. Biochem. Behav. 2008)
    387. Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration. (PubMed id 16932754)9 Lin H....Juang J.L. (Cell Death Differ. 2007)
    388. Study of the inhibition of cyclin-dependent kinases with roscovitine and indirubin-3'-oxime from molecular dynamics simulations. (PubMed id 16770643)9 Zhang B....Zhuang S. (J Mol Model 2007)
    389. Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death. (PubMed id 17117479)9 Lee J.H. and Kim K.T. (J. Cell. Physiol. 2007)
    390. Significance of water molecules in the inhibition of cylin-dependent kinase 2 and 5 complexes. (PubMed id 17713901)9 Zhang B....Tay T.E. (J Chem Inf Model 2007)
    391. Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons. (PubMed id 17166269)9 Hoe H.S....Rebeck G.W. (Mol Neurodegener 2006)
    392. Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. (PubMed id 16510591)9 Yang H.S. and Hinds P.W. (Cancer Res. 2006)
    393. Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5. (PubMed id 16818492)9 Vandebroek T....Van Leuven F. (J. Biol. Chem. 2006)
    394. Aberrant activation of CDK5 is involved in the pathogenesis of OPIDN. (PubMed id 16987246)9 Wang Y.P....Ju G. (J. Neurochem. 2006)
    395. Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35. (PubMed id 16802322)9 Hosokawa T....Hisanaga S. (J. Neurosci. Res. 2006)
    396. Molecular dynamics simulations on the inhibition of cyclin-dependent kinases 2 and 5 in the presence of activators. (PubMed id 17054019)9 Zhang B....Tay T.E. (J. Comput. Aided Mol. Des. 2006)
    397. Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium. (PubMed id 15979805)9 JordA E.G....Camins A. (Neuroscience 2005)
    398. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. (PubMed id 16242410)9 Kumar A....Nestler E.J. (Neuron 2005)
    399. Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. (PubMed id 17191919)9 Wu Z.L....Guengerich F.P. (amp 2005)
    400. Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. (PubMed id 15482916)9 Helal C.J....Peterson M. (amp 2004)
    401. Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. (PubMed id 15494405)9 Schneider A....Simons M. (J. Biol. Chem. 2004)
    402. Role of Cdk5 in drug abuse and plasticity. (PubMed id 15542734)9 Benavides D.R. and Bibb J.A. (Ann. N. Y. Acad. Sci. 2004)
    403. Cdk5 and Trio modulate endocrine cell exocytosis. (PubMed id 15331630)9 Xin X....Mains R.E. (J. Cell. Sci. 2004)
    404. Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation. (PubMed id 15289351)9 Chen F....Studzinski G.P. (Cancer Res. 2004)
    405. Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation. (PubMed id 12598607)9 Saito T....Hisanaga S. (J. Neurosci. 2003)
    406. Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis. (PubMed id 12941380)9 Jorda E.G....Camins A. (Neuropharmacology 2003)
    407. Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation. (PubMed id 12637947)9 Ferrer-AlcA^n M....GarcA-a-Sevilla J.A. (Neuropsychopharmacology 2003)
    408. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. (PubMed id 12928438)9 Bhat R....Avila J. (J. Biol. Chem. 2003)
    409. Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit (Pgamma) of retinal cgmp phosphodiesterase (PDE6): its implications in phototransduction. (PubMed id 12596920)9 Yamazaki A....Yamazaki R.K. (Adv. Exp. Med. Biol. 2002)
    410. Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model. (PubMed id 12151531)9 Bu B....Vincent I. (J. Neurosci. 2002)
    411. Tau neurofibrillary pathology and microtubule stability. (PubMed id 12540054)9 Michaelis M.L....Li G. (J. Mol. Neurosci. 2002)
    412. Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. (PubMed id 11805297)9 Papasozomenos S.C.h. and Shanavas A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    413. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. (PubMed id 11331872)9 Harada T....Nishida E. (Nat. Cell Biol. 2001)
    414. Oxygen free radical injury is sufficient to cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells. (PubMed id 12214088)9 de la Monte S.M....Wands J.R. (J. Alzheimers Dis. 2000)
    415. Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants. (PubMed id 11054815)9 Flaherty D.B....Wood J.G. (J. Neurosci. Res. 2000)
    416. Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells. (PubMed id 11080186)9 Zhang J. and Johnson G.V. (J. Neurochem. 2000)
    417. Identification and structure characterization of a Cdk inhibitory peptide derived from neuronal-specific Cdk5 activator. (PubMed id 10066770)9 Chin K.T....Zhang M. (J. Biol. Chem. 1999)
    418. Microtubule-stimulated phosphorylation of tau at Ser202 and Thr205 by cdk5 decreases its microtubule nucleation activity. (PubMed id 9756618)9 Wada Y....Hisanaga S. (J. Biochem. 1998)
    419. Differential expression of proteins regulating cell cycle progression in growth vs. differentiation. (PubMed id 9150273)9 Li Z....Bloch A. (Biochim. Biophys. Acta 1997)
    420. Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract. (PubMed id 7592534)9 Hosoi T....Hisanaga S. (J. Biochem. 1995)
    421. Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE. (PubMed id 20097924)9 Hosokawa T....Hisanaga S. (amp 2010)
    422. Neuroimmunomodulation in the pathogenesis of Alzheimer's disease. (PubMed id 20134203)9 Morales I....Maccioni R.B. (Neuroimmunomodulation 2010)
    423. Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases. (PubMed id 20356412)9 Wang G.R....Dong X.P. (BMC Infect. Dis. 2010)
    424. Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex. (PubMed id 20022952)9 Nishimura Y.V....Kawauchi T. (J. Biol. Chem. 2010)
    425. Molecular mechanisms of neurodegeneration in Alzheimer's disease. (PubMed id 20413653)9 Crews L. and Masliah E. (Hum. Mol. Genet. 2010)
    426. p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo. (PubMed id 20130526)9 Brinkkoetter P.T....Shankland S.J. (Kidney Int. 2010)
    427. Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins. (PubMed id 20153752)9 Zhou J....Chen J. (Life Sci. 2010)
    428. Expression of p25, an aberrant cyclin-dependent kinase 5 activator, stimulates basal secretion in PC12 cells. (PubMed id 20033852)9 Son M.Y. and Chung S.H. (Mol. Cells 2010)
    429. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. (PubMed id 20484029)9 Feldmann G....Nelkin B.D. (Cancer Res. 2010)
    430. Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. (PubMed id 19948833)9 Takahashi S....Kulkarni A.B. (Am. J. Pathol. 2010)
    431. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. (PubMed id 18930955)9 Chatterjee S....Jackson G.R. (Hum. Mol. Genet. 2009)
    432. Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins. (PubMed id 19940183)9 Rudrabhatla P....Pant H.C. (J. Neurosci. 2009)
    433. Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro. (PubMed id 19304664)9 Han D....Paudel H.K. (J. Biol. Chem. 2009)
    434. Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells. (PubMed id 19362124)9 Utreras E....GonzA!lez-Billault C. (Neuroscience 2009)
    435. Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A. (PubMed id 19071093)9 Martin L....Terro F. (Brain Res. 2009)
    436. Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator. (PubMed id 19638632)9 Endo R....Hisanaga S. (J. Biol. Chem. 2009)
    437. Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5. (PubMed id 19457112)9 Orlando L.R....Young A.B. (J. Neurochem. 2009)
    438. Molecular pathology of neuro-AIDS (CNS-HIV). (PubMed id 19399237)9 Crews L....Masliah E. (Int J Mol Sci 2009)
    439. The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling. (PubMed id 19156541)9 He Y....Pan W. (J. Mol. Neurosci. 2009)
    440. CDK5: the &quot;pathfinder&quot; for new born neurons in adult hippocampus? (PubMed id 19855173)9 Tobias A....Lelievre V. (amp 2009)
    441. Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium. (PubMed id 19689241)9 Camins A....PallA s M. (Curr. Drug Metab. 2009)
    442. Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk. (PubMed id 19154537)9 Mateo I....Combarros O. (Acta Neurol. Scand. 2009)
    443. Gene expression analysis on anterior temporal neocortex of patients with intractable epilepsy. (PubMed id 19623530)9 Xi Z.Q....Liu G.W. (Synapse 2009)
    444. Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. (PubMed id 19864130)9 Kaller M.R....Norman M.H. (amp 2009)
    445. Cyclin-dependent kinase-5 targeting for ischaemic stroke. (PubMed id 18983942)9 Slevin M. and Krupinski J. (Curr Opin Pharmacol 2009)
    446. Upregulation of GSK3beta expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci). (PubMed id 18221734)9 Yang W....Strong M.J. (Brain Res. 2008)
    447. Mechanism of arsenic-induced neurotoxicity may be explained through cleavage of p35 to p25 by calpain. (PubMed id 18242949)9 Vahidnia A....de Wolff F.A. (Toxicol In Vitro 2008)
    448. WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. (PubMed id 18287015)9 Sung J.Y....Kim Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    449. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. (PubMed id 19118186)9 Sato S....Ikezu T. (J. Neurosci. 2008)
    450. Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors. (PubMed id 18184784)9 Zhang S....Morabito M.A. (J. Neurosci. 2008)
    451. GSK-3 mediates the okadaic acid-induced modification of collapsin response mediator protein-2 in human SK-N-SH neuroblastoma cells. (PubMed id 17902168)9 Ni M.H....Yu J.S. (J. Cell. Biochem. 2008)
    452. Fish and apoptosis: studies in disease and pharmaceutical design. (PubMed id 18220828)9 Silva M.T....dos Santos N.M. (Curr. Pharm. Des. 2008)
    453. DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. (PubMed id 18391978)9 Lockwood W.W....Lam W.L. (Oncogene 2008)
    454. Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. (PubMed id 18218617)9 Patrakitkomjorn S....Araki N. (J. Biol. Chem. 2008)
    455. A cell-based screening method for specifically detecting kinase activity. (PubMed id 17985120)9 Suda M....Noumi T. (Anal Bioanal Chem 2008)
    456. Phosphatidylinositide 3-kinase and protein kinase C zeta mediate retinoic acid induction of DARPP-32 in medium size spiny neurons in vitro. (PubMed id 18485106)9 Pedrini S....Ehrlich M.E. (J. Neurochem. 2008)
    457. The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. (PubMed id 18075258)9 Sen A....Sisodiya S.M. (Dev. Neurosci. 2008)
    458. Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau. (PubMed id 18691381)9 Sotiropoulos I....Almeida O.F. (J. Neurochem. 2008)
    459. Che-1 enhances cyclin-dependent kinase 5 expression and interacts with the active kinase-complex. (PubMed id 18388733)9 Buontempo S....Passananti C. (Neuroreport 2008)
    460. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity. (PubMed id 18082850)9 Contet C....Kieffer B.L. (Neuropharmacology 2008)
    461. Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. (PubMed id 18855662)9 Gong C.X. and Iqbal K. (Curr. Med. Chem. 2008)
    462. CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation. (PubMed id 18948252)9 Okada S....Mori M. (J. Biol. Chem. 2008)
    463. Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy. (PubMed id 18808062)9 Honjo Y....Akiguchi I. (Clin. Neuropathol. 2008)
    464. Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons. (PubMed id 18075253)9 Kawauchi T. and Hoshino M. (Dev. Neurosci. 2008)
    465. Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. (PubMed id 18194444)9 Iqbal K. and Grundke-Iqbal I. (J. Cell. Mol. Med. 2008)
    466. Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells. (PubMed id 18947885)9 Ojala J.O....PirttilAo T. (J. Neuroimmunol. 2008)
    467. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons. (PubMed id 18289510)9 Chen X....Zhu Y. (Brain Res. 2008)
    468. Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy. (PubMed id 18413795)9 Zhang C....Jessen B. (Mol. Cancer Ther. 2008)
    469. Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development. (PubMed id 17850624)9 Wynshaw-Boris A. (Clin. Genet. 2007)
    470. Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity. (PubMed id 17897354)9 Wang Y....Jordan-Sciutto K.L. (J. Neurochem. 2007)
    471. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. (PubMed id 17683481)9 Cole A.R....Sutherland C. (J. Neurochem. 2007)
    472. Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (PubMed id 17113760)9 Wen Y....Simpkins J.W. (Biochim. Biophys. Acta 2007)
    473. Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival. (PubMed id 17108320)9 Zheng Y.L....Pant H.C. (Mol. Biol. Cell 2007)
    474. Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. (PubMed id 17709247)9 Zhong W....Norman M.H. (amp 2007)
    475. The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias. (PubMed id 17188499)9 Kuan W.L....Barker R.A. (Neurobiol. Dis. 2007)
    476. The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration. (PubMed id 17634293)9 Muresan Z. and Muresan V. (Mol. Biol. Cell 2007)
    477. Roscovitine differentially affects CaV2 and Kv channels by binding to the open state. (PubMed id 17125805)9 Buraei Z....Elmslie K.S. (Neuropharmacology 2007)
    478. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. (PubMed id 17368005)9 Connell-Crowley L....Giniger E. (Mech. Dev. 2007)
    479. Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors. (PubMed id 17697781)9 Rzasa R.M....Norman M.H. (amp 2007)
    480. Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization. (PubMed id 17868322)9 Nguyen C....Bibb J.A. (J. Neurochem. 2007)
    481. The roles of cyclin-dependent kinase 5 in dendrite and synapse development. (PubMed id 17526057)9 Cheung Z.H. and Ip N.Y. (Biotechnol J 2007)
    482. Alternative roles for Cdk5 in learning and synaptic plasticity. (PubMed id 17597494)9 Hawasli A.H. and Bibb J.A. (Biotechnol J 2007)
    483. AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. (PubMed id 17209049)9 Bogush A....Ehrlich M.E. (J. Biol. Chem. 2007)
    484. Cerebral ischemia, cell cycle elements and Cdk5. (PubMed id 17619233)9 Timsit S. and Menn B. (Biotechnol J 2007)
    485. Novel insights into the beneficial and detrimental actions of cdk5. (PubMed id 17932412)9 Giese K.P. (Mol. Interv. 2007)
    486. Identification of small molecules that interfere with radial neuronal migration and early cortical plate development. (PubMed id 16481563)9 Zhou L....Goffinet A.M. (Cereb. Cortex 2007)
    487. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. (PubMed id 17241267)9 Wang J.Z....Iqbal K. (Eur. J. Neurosci. 2007)
    488. Pathological tau tangles localize to focal cortical dysplasia in older patients. (PubMed id 17441989)9 Sen A....Sisodiya S.M. (Epilepsia 2007)
    489. The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. (PubMed id 17535922)9 Ahn J.H....Nairn A.C. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    490. Increased immunoreactivity of cdk5 activators in hippocampal sclerosis. (PubMed id 17496813)9 Sen A....Sisodiya S.M. (Neuroreport 2007)
    491. p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons. (PubMed id 17506859)9 Saito T....Hisanaga S. (J. Neurochem. 2007)
    492. Kinase activities increase during the development of tauopathy in htau mice. (PubMed id 17908241)9 Kelleher I....Noble W. (J. Neurochem. 2007)
    493. Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase. (PubMed id 17150266)9 Orellana D.I....Maccioni R.B. (Biochim. Biophys. Acta 2007)
    494. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. (PubMed id 16611631)9 Cole A.R.... Sutherland C. (J. Biol. Chem. 2006)
    495. Selectivity and potency of cyclin-dependent kinase inhibitors. (PubMed id 16584130)9 Sridhar J....Pattabiraman N. (AAPS J 2006)
    496. DARPP-32 is a robust integrator of dopamine and glutamate signals. (PubMed id 17194217)9 Fernandez E....Le NovA"re N. (PLoS Comput. Biol. 2006)
    497. Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. (PubMed id 17168675)9 Narayanan B.A. (Curr Cancer Drug Targets 2006)
    498. Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia. (PubMed id 16815303)9 Morioka M....Kuratsu J. (Biochem. Biophys. Res. Commun. 2006)
    499. Involvement of calpain activation in neurodegenerative processes. (PubMed id 16958987)9 Camins A....PallA s M. (CNS Drug Rev 2006)
    500. Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. (PubMed id 16759647)9 Chau K.W....Chan H.Y. (Biochem. Biophys. Res. Commun. 2006)
    501. p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death. (PubMed id 16021178)9 Lin L....Zakeri Z. (Cell Death Differ. 2006)
    502. Parkin potentiates ATP-induced currents due to activation of P2X receptors in PC12 cells. (PubMed id 16826604)9 Sato A....Noda M. (J. Cell. Physiol. 2006)
    503. [Role of astrocytes in rewarding effects of drugs of abuse]. (PubMed id 16637594)9 Narita M....Suzuki T. (Nihon Shinkei Seishin Yakurigaku Zasshi 2006)
    504. Tau therapeutic strategies for the treatment of Alzheimer's disease. (PubMed id 16712493)9 Churcher I. (Curr Top Med Chem 2006)
    505. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. (PubMed id 15999992)9 Kuo G.H....Murray W.V. (J. Med. Chem. 2005)
    506. Aberrant splicing of cables gene, a CDK regulator, in human cancers. (PubMed id 16177568)9 Zhang H....Wu C.L. (amp 2005)
    507. Interaction of Tau with Fe65 links tau to APP. (PubMed id 15686969)9 Barbato C....Calissano P. (Neurobiol. Dis. 2005)
    508. Evaluation of the neuronal apoptotic pathways involved in cytoskeletal disruption-induced apoptosis. (PubMed id 15950951)9 JordA E.G....Camins A. (Biochem. Pharmacol. 2005)
    509. Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway. (PubMed id 15695523)9 Song J.H....Hao C. (J. Biol. Chem. 2005)
    510. Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. (PubMed id 15689157)9 Lu H.... Schulze-Gahmen U. (J. Med. Chem. 2005)
    511. Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. (PubMed id 16166266)9 Rashidian J....Park D.S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    512. Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons. (PubMed id 16040813)9 Hamada M....Nishi A. (J. Pharmacol. Exp. Ther. 2005)
    513. DARPP-32 mediates the actions of multiple drugs of abuse. (PubMed id 16353915)9 Svenningsson P....Greengard P. (AAPS J 2005)
    514. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. (PubMed id 15592431)9 Zheng Y.L....Pant H.C. (EMBO J. 2005)
    515. Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. (PubMed id 15601849)9 Lambourne S.L....Wilkinson L.S. (Mol. Cell. Biol. 2005)
    516. Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs. (PubMed id 15836613)9 Johnson K....D'Mello S.R. (J. Neurochem. 2005)
    517. Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity. (PubMed id 15836929)9 Moran C.M....Shea T.B. (Brain Res. Mol. Brain Res. 2005)
    518. Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. (PubMed id 15514976)9 Aubert I....Bezard E. (Ann. Neurol. 2005)
    519. Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities. (PubMed id 15927836)9 Sondhi S.M....Meijer L. (amp 2005)
    520. Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau. (PubMed id 15843619)9 Darios F....Ruberg M. (J. Neurosci. 2005)
    521. Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory. (PubMed id 15978013)9 Ris L....Giese K.P. (Eur. J. Neurosci. 2005)
    522. Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. (PubMed id 15919659)9 Yu W....Michikawa M. (J. Biol. Chem. 2005)
    523. Combinatorial ligand design targeted at protein families. (PubMed id 15807493)9 Todorov N.P....Alberts I.L. (J Chem Inf Model 2005)
    524. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (PubMed id 16203747)9 Toyo-Oka K.... Hirotsune S. (Hum. Mol. Genet. 2005)
    525. Cdk5: mediator of neuronal death and survival. (PubMed id 15135890)9 Cheung Z.H. and Ip N.Y. (Neurosci. Lett. 2004)
    526. The role of DARPP-32 in the actions of drugs of abuse. (PubMed id 15464122)9 Nairn A.C....Greengard P. (Neuropharmacology 2004)
    527. Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors. (PubMed id 15308730)9 Diwan P....Schang L.M. (J. Virol. 2004)
    528. Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. (PubMed id 15006135)9 Ahn J.S....Yeh L.A. (J Biomol Screen 2004)
    529. PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. (PubMed id 15006350)9 Nishimura I....Lu B. (Cell 2004)
    530. DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia. (PubMed id 15196506)9 HAYkansson K....Fisone G. (amp 2004)
    531. Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanism. (PubMed id 14602088)9 Verdaguer E....Camins A. (Neurochem. Int. 2004)
    532. Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo. (PubMed id 15489225)9 Liu J....Stuenkel E.L. (J. Biol. Chem. 2004)
    533. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1. (PubMed id 15135175)9 Zambrano C.A....GonzA!lez-Billault C. (amp 2004)
    534. Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells. (PubMed id 14976144)9 Ubeda M....Habener J.F. (Endocrinology 2004)
    535. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. (PubMed id 15350898)9 Cruz J.C. and Tsai L.H. (Trends Mol Med 2004)
    536. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. (PubMed id 15056716)9 Wang Q....Anwyl R. (J. Neurosci. 2004)
    537. Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration. (PubMed id 14712065)9 Xie Z. and Tsai L.H. (Cell Cycle 2004)
    538. Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. (PubMed id 15051507)9 Quintanilla R.A....Maccioni R.B. (Exp. Cell Res. 2004)
    539. MARKing tau for tangles and toxicity. (PubMed id 15450610)9 Drewes G. (Trends Biochem. Sci. 2004)
    540. Rho/ROCK and Cdk5 effects on phosphorylation of a beta-thymosin repeat protein in Hermissenda. (PubMed id 15369765)9 Crow T....Tian L.M. (Biochem. Biophys. Res. Commun. 2004)
    541. Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. (PubMed id 15248095)9 Svenson I.K.... Marchuk D.A. (Neurogenetics 2004)
    542. Involvement of cyclin dependent kinase 5 and its activator p35 in staurosporine-induced apoptosis of cortical neurons. (PubMed id 15339383)9 Zhang B.F....Wu D.C. (Acta Pharmacol. Sin. 2004)
    543. Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice. (PubMed id 15331409)9 Zhang M....Vincent I. (Am. J. Pathol. 2004)
    544. Analysis of roscovitine using novel high performance liquid chromatography and UV-detection method: pharmacokinetics of roscovitine in rat. (PubMed id 15013157)9 Vita M....Hassan M. (J Pharm Biomed Anal 2004)
    545. Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (PubMed id 15483118)9 Brown M....Hall C. (J. Neurosci. 2004)
    546. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. (PubMed id 14612456)9 Shimura H....Kosik K.S. (J. Biol. Chem. 2004)
    547. Cdk5, a therapeutic target for Alzheimer's disease? (PubMed id 15023356)9 Tsai L.H....Cruz J. (Biochim. Biophys. Acta 2004)
    548. The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. (PubMed id 15184080)9 JAomsAo A....VasAonge M. (Biochem. Biophys. Res. Commun. 2004)
    549. Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation. (PubMed id 15067201)9 Gompel M....Meijer L. (Neurosignals 2004)
    550. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. (PubMed id 15322121)9 Harris F.M....Huang Y. (J. Biol. Chem. 2004)
    551. DARPP-32: an integrator of neurotransmission. (PubMed id 14744247)9 Svenningsson P....Greengard P. (Annu. Rev. Pharmacol. Toxicol. 2004)
    552. Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones. (PubMed id 14695817)9 Kunick C....Lemcke T. (J. Med. Chem. 2004)
    553. A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. (PubMed id 15152189)9 Morfini G....Brady S.T. (EMBO J. 2004)
    554. Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells. (PubMed id 14664814)9 Cheng Q....Goshima Y. (Mol. Cell. Neurosci. 2003)
    555. Cyclin-dependent kinases in neural development and degeneration. (PubMed id 14624029)9 Lim A.C. and Qi R.Z. (J. Alzheimers Dis. 2003)
    556. Gene expression networks underlying retinoic acid-induced differentiation of human retinoblastoma cells. (PubMed id 12601020)9 Li A....Craft C.M. (amp 2003)
    557. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. (PubMed id 12684463)9 Patzke H....Tsai L.H. (J. Neurosci. 2003)
    558. Cdk5: one of the links between senile plaques and neurofibrillary tangles? (PubMed id 12719630)9 Lee M.S. and Tsai L.H. (J. Alzheimers Dis. 2003)
    559. Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells. (PubMed id 12577309)9 Strocchi P....Dozza B. (J. Cell. Biochem. 2003)
    560. Characterization of gastrin-induced cytostatic effect on cell proliferation in experimental malignant gliomas. (PubMed id 12657185)9 Lefranc F....Kiss R. (Neurosurgery 2003)
    561. Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis? (PubMed id 14555242)9 Hamdane M....BuAce L. (Biochem. Pharmacol. 2003)
    562. Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis. (PubMed id 14673208)9 Nguyen M.D. and Julien J.P. (Neurosignals 2003)
    563. Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction. (PubMed id 14572469)9 Weishaupt J.H....Gillardon F. (Mol. Cell. Neurosci. 2003)
    564. Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. (PubMed id 12897406)9 Chen G.J....de la Monte S.M. (J. Alzheimers Dis. 2003)
    565. Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions. (PubMed id 12740122)9 Schuman E.M. and Murase S. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2003)
    566. Cyclin-dependent kinase 5 in neurofilament function and regulation. (PubMed id 14673212)9 Kesavapany S....Pant H.C. (Neurosignals 2003)
    567. Cell cycle arrest biomarkers in human lung cancer cells after treatment with selenium in culture. (PubMed id 14652289)9 Swede H....Ip C. (amp 2003)
    568. Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. (PubMed id 12657672)9 Nguyen M.D....Julien J.P. (J. Neurosci. 2003)
    569. Binding of cGMP to GAF domains in amphibian rod photoreceptor cGMP phosphodiesterase (PDE). Identification of GAF domains in PDE alphabeta subunits and distinct domains in the PDE gamma subunit involved in stimulation of cGMP binding to GAF domains. (PubMed id 12177054)9 Yamazaki M....Yamazaki A. (J. Biol. Chem. 2002)
    570. Cycling at the interface between neurodevelopment and neurodegeneration. (PubMed id 12478466)9 Nguyen M.D....Julien J.P. (Cell Death Differ. 2002)
    571. Cdk5 sinks into ALS. (PubMed id 11801324)9 Patzke H. and Tsai L.H. (Trends Neurosci. 2002)
    572. A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells. (PubMed id 12230554)9 Zheng Y.L....Pant H.C. (Eur. J. Biochem. 2002)
    573. Glutamate-mediated striatal dysregulation and the pathogenesis of motor response complications in Parkinson's disease. (PubMed id 12373527)9 Oh J.D. and Chase T.N. (Amino Acids 2002)
    574. Abnormal expression of cdk5 in focal cortical dysplasia in humans. (PubMed id 12147310)9 Sisodiya S.M....Harding B.N. (Neurosci. Lett. 2002)
    575. Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. (PubMed id 11882652)9 Wei W....Kusiak J.W. (J. Biol. Chem. 2002)
    576. Cdk5 as a drug target for the treatment of Alzheimer's disease. (PubMed id 12540052)9 Lau L.F....Schachter J.B. (J. Mol. Neurosci. 2002)
    577. Myofibrillar (desmin-related) myopathy: clinico-pathological spectrum in 3 cases and review of the literature. (PubMed id 12365725)9 Wanschit J....Budka H. (Clin. Neuropathol. 2002)
    578. Fast axonal transport misregulation and Alzheimer's disease. (PubMed id 12428805)9 Morfini G....Brady S.T. (Neuromolecular Med. 2002)
    579. Beta-carbolines as specific inhibitors of cyclin-dependent kinases. (PubMed id 11909733)9 Song Y....Sim M.M. (amp 2002)
    580. Evidence that Fas-induced apoptosis leads to S phase arrest. (PubMed id 11295463)9 N'cho M. and Brahmi Z. (Hum. Immunol. 2001)
    581. P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy. (PubMed id 11307616)9 Honjyo Y....Akiguchi I. (Acta Neuropathol. 2001)
    582. Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo. (PubMed id 11413244)9 Neystat M....Burke R.E. (J. Neurochem. 2001)
    583. Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize. (PubMed id 11483735)9 Advani S.J....Roizman B. (J. Virol. 2001)
    584. Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures. (PubMed id 11157084)9 Wenzel H.J....Schwartzkroin P.A. (J. Neurosci. 2001)
    585. Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain. (PubMed id 11403952)9 Takashima A....Ishiguro K. (Neurosci. Lett. 2001)
    586. Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism. (PubMed id 11248670)9 Grant P....Pant H.C. (Eur. J. Biochem. 2001)
    587. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. (PubMed id 11231011)9 Taniguchi S....Hasegawa M. (FEBS Lett. 2001)
    588. Protein-protein interactions, cytoskeletal regulation and neuronal migration. (PubMed id 11389474)9 Feng Y. and Walsh C.A. (Nat. Rev. Neurosci. 2001)
    589. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? (PubMed id 11013232)9 Leclerc S....Meijer L. (J. Biol. Chem. 2001)
    590. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. (PubMed id 11707776)9 Walentinsson A....Levan G. (Mamm. Genome 2001)
    591. Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. (PubMed id 11278334)9 Bibb J.A....Greengard P. (J. Biol. Chem. 2001)
    592. Structural Insights into Cdk5 activation by a neuronal Cdk5 activator. (PubMed id 11437375)9 Lim H.Y....Qi R.Z. (Biochem. Biophys. Res. Commun. 2001)
    593. Cdk5 on the brain. (PubMed id 11432802)9 Smith D.S....Tsai L.H. (amp 2001)
    594. Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue. (PubMed id 10722743)9 Le Roch K....Doerig C. (J. Biol. Chem. 2000)
    595. Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit of retinal cGMP phosphodiesterase. II. Its role in the turnoff of phosphodiesterase in vivo. (PubMed id 10884379)9 Hayashi F....Yamazaki A. (J. Biol. Chem. 2000)
    596. Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. (PubMed id 10749861)9 Sobue K....Paudel H.K. (J. Biol. Chem. 2000)
    597. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PubMed id 10965112)9 Muravenko O.V....Zelenin A.V. (Cytogenet. Cell Genet. 2000)
    598. Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease. (PubMed id 10799694)9 Takahashi M....Kosaka K. (Brain Res. 2000)
    599. Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells. (PubMed id 10896783)9 Hsu S.L....Chang C.D. (Exp. Cell Res. 2000)
    600. Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains. (PubMed id 10620662)9 Takahashi M....Kosaka K. (J. Neurol. Sci. 2000)
    601. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. (PubMed id 10706614)9 Ahlijanian M.K....McNeish J.D. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    602. Potential mechanisms of mutations that affect neuronal migration in man and mouse. (PubMed id 10826984)9 Walsh C.A. and Goffinet A.M. (amp 2000)
    603. Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines. (PubMed id 10873769)9 Platt G.M....Mittnacht S. (Virology 2000)
    604. Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS. (PubMed id 10509378)9 Bajaj N.P....Miller C.C. (amp 1999)
    605. Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors. (PubMed id 10465404)9 Legraverend M....Favaudon V. (amp 1999)
    606. Role of cdk5 and tau phosphorylation in heterotrimeric G protein-mediated retinal growth cone collapse. (PubMed id 10526312)9 Nakayama T....Kato T. (J. Neurobiol. 1999)
    607. Binding and catalytic properties of the Cdc2 and Crp proteins of Dictyostelium. (PubMed id 10102987)9 Sharma S.K....Weeks G. (Eur. J. Biochem. 1999)
    608. Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. (PubMed id 10413323)9 Lee K.Y....Johnston R.N. (Neurosci. Res. 1999)
    609. Identification of substrate binding site of cyclin-dependent kinase 5. (PubMed id 10092646)9 Sharma P....Pant H.C. (J. Biol. Chem. 1999)
    610. Involvement of cyclin D1-cdk5 overexpression and MCM3 cleavage in bax-associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model. (PubMed id 10495426)9 Yin M.B....Rustum Y.M. (Int. J. Cancer 1999)
    611. Free PKC catalytic subunits (PKM) phosphorylate tau via a pathway distinct from that utilized by intact PKC. (PubMed id 10629766)9 Ekinci F.J. and Shea T.B. (Brain Res. 1999)

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    Entrez Gene: 1020 HGNC: 1774 AceView: CDK5 Ensembl:ENSG00000164885 euGenes: HUgn1020
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    PharmGKB entry for CDK5 Pharmacogenomics, SNPs, Pathways
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