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CDK5 Gene(Protein Coding)

Cyclin Dependent Kinase 5

GCID:
GC07M151053
GIFtS:
74
Genes Participants
UDN Logo

Aliases for CDK5 Gene

Aliases for CDK5 Gene

  • Cyclin Dependent Kinase 5 2 3 5
  • Serine/Threonine-Protein Kinase PSSALRE 3 4
  • Tau Protein Kinase II Catalytic Subunit 3 4
  • Cell Division Protein Kinase 5 3 4
  • TPKII Catalytic Subunit 3 4
  • Cyclin-Dependent-Like Kinase 5 3
  • Protein Kinase CDK5 Splicing 3
  • EC 2.7.11.22 61
  • EC 2.7.11.1 4
  • EC 2.7.11 61
  • PSSALRE 3
  • CDKN5 4
  • LIS7 3

External Ids for CDK5 Gene

Previous GeneCards Identifiers for CDK5 Gene

  • GC07M148997
  • GC07M150065
  • GC07M150142
  • GC07M150188
  • GC07M150381
  • GC07M150750
  • GC07M144563

Summaries for CDK5 Gene

Entrez Gene Summary for CDK5 Gene

  • This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

GeneCards Summary for CDK5 Gene

CDK5 (Cyclin Dependent Kinase 5) is a Protein Coding gene. Diseases associated with CDK5 include Lissencephaly 7 With Cerebellar Hypoplasia and Lissencephaly. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Development HGF signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK3.

UniProtKB/Swiss-Prot for CDK5 Gene

  • Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Tocris Summary for CDK5 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5 Gene

Genomics for CDK5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CDK5 Gene

Enhancers for CDK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G151007 2 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +47.4 47404 7.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B DMAP1 SLC30A9 NOS3 KCNH2 ASIC3 SLC4A2 CDK5 ENSG00000244151 FASTK TMUB1 AGAP3 GBX1
GH07G151017 1.6 Ensembl ENCODE dbSUPER 11.5 +40.2 40156 2.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B DMAP1 ZNF2 ZBTB7B YY1 ABCB8 NOS3 KCNH2 ASIC3 SLC4A2 CDK5 AGAP3 TMUB1 ENSG00000244151 FASTK
GH07G151084 1.4 FANTOM5 ENCODE 11.6 -29.3 -29258 5.9 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 GLIS1 NBN ABCB8 SLC4A2 AGAP3 FASTK CDK5 ASIC3 SMARCD3 GBX1 ASB10 ENSG00000243433
GH07G151091 1.1 Ensembl ENCODE 11.6 -33.0 -32971 0.6 HDAC1 TBL1XR1 SIN3A INSM2 ZBTB40 RAD21 ZNF766 ZNF143 CREM HCFC1 AGAP3 SLC4A2 CDK5 ASIC3 GBX1 ASB10 ENSG00000243433 ABCB8 ATG9B ABCF2
GH07G151003 0.9 ENCODE 11.1 +54.7 54650 1.0 HDAC1 HDGF PKNOX1 ATF1 FOXA2 TBL1XR1 CREB3L1 FOS REST ZNF592 KCNH2 ATG9B ABCB8 ENSG00000243433 ASIC3 SLC4A2 CDK5 ENSG00000244151 TMUB1 FASTK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK5 on UCSC Golden Path with GeneCards custom track

Promoters for CDK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000329085 530 1201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1
ENSR00000219779 -1470 1201 HDGF AGO1 ARID4B SIN3A ZNF766 GLIS2 ELK1 KLF7 KDM4B SP3

Transcription factor binding sites by QIAGEN in the CDK5 gene promoter:

Genomic Location for CDK5 Gene

Chromosome:
7
Start:
151,053,812 bp from pter
End:
151,058,530 bp from pter
Size:
4,719 bases
Orientation:
Minus strand

Genomic View for CDK5 Gene

Genes around CDK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK5 Gene

Proteins for CDK5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00535-CDK5_HUMAN
    Recommended name:
    Cyclin-dependent-like kinase 5
    Protein Accession:
    Q00535
    Secondary Accessions:
    • A1XKG3

    Protein attributes for CDK5 Gene

    Size:
    292 amino acids
    Molecular mass:
    33304 Da
    Quaternary structure:
    • Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity). The complex p35/CDK5 interacts with CLOCK. Interacts with HTR6 (By similarity).
    Miscellaneous:
    • Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.

    Three dimensional structures from OCA and Proteopedia for CDK5 Gene

    Alternative splice isoforms for CDK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK5 Gene

Protein Expression for CDK5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CDK5 Gene

Q00535:
  • LVFEFCD
  • NIVRLHD
  • IFRLLGTP
  • GELKLADFGLA
  • DFGLARA
  • DVLHSDKKLTLVFE
  • SLVNVVPKLNATGRDLLQNLLKCNPVQRI
  • WSAGCIF
  • RISAEEAL
  • VVTLWYR
  • LADFGLA
  • VLHRDLK
  • DFGLARAFG
  • GRPLFPG
  • LGTPTEE
  • DDEGVPSSALREICLLKELKHKNIVRL
  • CYSAEVVTLWYRPPDVLFGAKLY
  • HRDLKPQN
  • DQDLKKY
  • IGEGTYG

Post-translational modifications for CDK5 Gene

  • Phosphorylation at Ser-159 is essential for maximal catalytic activity.
  • Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.
  • Ubiquitination at Lys20, Lys128, posLast=141141, and posLast=268268
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK5 (CDK5)

Assay Products

  • Cloud-Clone Corp Assay Kits for CDK5

Domains & Families for CDK5 Gene

Gene Families for CDK5 Gene

HGNC:
IUPHAR :

Protein Domains for CDK5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00535

UniProtKB/Swiss-Prot:

CDK5_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK5: view

Function for CDK5 Gene

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Molecular function for CDK5 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for activation with its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and cAMP regulated and modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant increase in CDK5 kinase activity,hyperphosphorylation of tau which reduces taus ability to associate microtubules
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration.
UniProtKB/Swiss-Prot Function:
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Enzyme Numbers (IUBMB) for CDK5 Gene

Gene Ontology (GO) - Molecular Function for CDK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0004672 protein kinase activity TAS 1639063
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0005176 ErbB-2 class receptor binding ISS --
genes like me logo Genes that share ontologies with CDK5: view
genes like me logo Genes that share phenotypes with CDK5: view

Human Phenotype Ontology for CDK5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDK5 Gene

MGI Knock Outs for CDK5:

Animal Model Products

CRISPR Products

miRNA for CDK5 Gene

miRTarBase miRNAs that target CDK5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK5

No data available for Transcription Factor Targets and HOMER Transcription for CDK5 Gene

Localization for CDK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5 Gene

Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium. Cell projection, growth cone. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. {ECO:0000250}.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK5 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for CDK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CDK5: view

Pathways & Interactions for CDK5 Gene

genes like me logo Genes that share pathways with CDK5: view

SIGNOR curated interactions for CDK5 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CDK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration TAS 21473899
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis IEA --
genes like me logo Genes that share ontologies with CDK5: view

Drugs & Compounds for CDK5 Gene

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(60) Drugs for CDK5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Flavopiridol Experimental, Investigational Pharma Target Pan-cdk inhibitor 0
Olomoucine Experimental Pharma Target, inhibitor 0
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Experimental Pharma Target 0
Alsterpaullone Experimental Pharma Target 0

(20) Additional Compounds for CDK5 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
PD 0332991 isethionate
827022-33-3

(5) Tocris Compounds for CDK5 Gene

Compound Action Cas Number
BMS 265246 Potent cdk1/2 inhibitor 582315-72-8
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 142273-20-9
PD 0332991 isethionate Potent, selective Cdk4/6 inhibitor; brain penetrant 827022-33-3
Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor 872573-93-8
Senexin A Cyclin-dependent kinase 8 (cdk8) inhibitor

(13) ApexBio Compounds for CDK5 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive 1241675-76-2
AT7519 Multi-CDK inhibitor 844442-38-2
BS-181 HCl CDK7 inhibitor,highly selective 1397219-81-6
CDK inhibitor II 1269815-17-9
Dinaciclib (SCH727965) Potent CDK inhibitor 779353-01-4
Flavopiridol Pan-cdk inhibitor 146426-40-6
Kenpaullone 142273-20-9
NSC 693868 40254-90-8
NVP-LCQ195 CDK1/CDK2/CDK5 inhibitor 902156-99-4
PF 4800567 hydrochloride 1391052-28-0
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Roscovitine (Seliciclib,CYC202) CDK inhibitor,potent and selective 186692-46-6
TMCB 905105-89-7
genes like me logo Genes that share compounds with CDK5: view

Drug Products

Transcripts for CDK5 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CDK5 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(122) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK5 Gene

Cyclin-dependent kinase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK5

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6:
SP7: -

Relevant External Links for CDK5 Gene

GeneLoc Exon Structure for
CDK5
ECgene alternative splicing isoforms for
CDK5

Expression for CDK5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK5 Gene

mRNA expression in normal human tissues for CDK5 Gene
mRNA expression by BioGPS for CDK5 GenemRNA expression by GTEx for CDK5 Gene

Protein differential expression in normal tissues from HIPED for CDK5 Gene

This gene is overexpressed in Frontal cortex (12.4), Fetal Brain (8.0), and Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK5 Gene



Protein tissue co-expression partners for CDK5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK5 Gene:

CDK5

SOURCE GeneReport for Unigene cluster for CDK5 Gene:

Hs.647078

mRNA Expression by UniProt/SwissProt for CDK5 Gene:

Q00535-CDK5_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.

Evidence on tissue expression from TISSUES for CDK5 Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Kidney(2.2)
  • Adrenal gland(2)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK5 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • lymphatic
  • nervous
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • lymph node
  • lymph vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
genes like me logo Genes that share expression patterns with CDK5: view

Primer Products

No data available for mRNA differential expression in normal tissues for CDK5 Gene

Orthologs for CDK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDK5 34 35
  • 99.66 (n)
cow
(Bos Taurus)
 Mammalia CDK5 34 35
  • 92.35 (n)
dog
(Canis familiaris)
 Mammalia CDK5 34 35
  • 91.78 (n)
mouse
(Mus musculus)
 Mammalia Cdk5 34 16 35
  • 90.87 (n)
rat
(Rattus norvegicus)
 Mammalia Cdk5 34
  • 90.07 (n)
oppossum
(Monodelphis domestica)
 Mammalia CDK5 35
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CDK5 34 35
  • 83.56 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdk5 34
  • 83.22 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.67 34
zebrafish
(Danio rerio)
 Actinopterygii cdk5 34 35
  • 77.74 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005772 34
  • 73.03 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Cdk5 36 34 35
  • 70.72 (n)
CG6800 36
  • 39 (a)
worm
(Caenorhabditis elegans)
 Secernentea cdk-5 34 35
  • 64.7 (n)
H01G02.2 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGL242C 34
  • 61.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PHO85 34 35
  • 60.47 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D11990g 34
  • 56.61 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1504 35
  • 70 (a)
 OneToOne
bread mold
(Neurospora crassa)
 Ascomycetes NCU07580 34
  • 60.92 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes pef1 34
  • 57.98 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2120 34
Species where no ortholog for CDK5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5 Gene

ENSEMBL:
Gene Tree for CDK5 (if available)
TreeFam:
Gene Tree for CDK5 (if available)

Paralogs for CDK5 Gene

Variants for CDK5 Gene

Sequence variations from dbSNP and Humsavar for CDK5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs786205164 Pathogenic 151,055,276(-) TGCAG(A/G)TGATG splice-donor-variant
rs1000324881 -- 151,054,558(+) GATTC(C/G)TCATA intron-variant
rs1000675589 -- 151,054,779(+) CACCT(C/G)GAGGG intron-variant
rs1001064694 -- 151,057,383(+) CGGTT(A/G)CCAGG intron-variant, upstream-variant-2KB
rs1001323510 -- 151,057,711(+) AGATC(A/G)GAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDK5 Gene

Variant ID Type Subtype PubMed ID
dgv11724n54 CNV loss 21841781
dgv3695n106 OTHER inversion 24896259
dgv6756n100 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv524928 CNV gain 19592680
nsv526410 CNV loss 19592680
nsv831188 CNV loss 17160897
nsv951648 CNV deletion 24416366

Variation tolerance for CDK5 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK5 Gene

Human Gene Mutation Database (HGMD)
CDK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5 Gene

Disorders for CDK5 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CDK5 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lissencephaly 7 with cerebellar hypoplasia
  • lissencephaly 7, with cerebellar hypoplasia
lissencephaly
ischemia
  • acute coronary syndrome
lissencephaly with cerebellar hypoplasia
  • lissencephaly 2
aneurysmal bone cysts
  • aneurysmal bone cyst
- elite association - COSMIC cancer census association via MalaCards
Search CDK5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK5_HUMAN
  • Lissencephaly 7, with cerebellar hypoplasia (LIS7) [MIM:616342]: A form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS7 patients manifest lack of psychomotor development, facial dysmorphism, arthrogryposis, and early-onset intractable seizures resulting in death in infancy. {ECO:0000269 PubMed:25560765}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDK5

Genetic Association Database (GAD)
CDK5
Human Genome Epidemiology (HuGE) Navigator
CDK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK5
genes like me logo Genes that share disorders with CDK5: view

No data available for Genatlas for CDK5 Gene

Publications for CDK5 Gene

  1. Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. (PMID: 19343042) Choi H.S. … Kim Y.H. (J. Hum. Genet. 2009) 3 22 46 64
  2. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PMID: 17591690) Lee J.-H. … Kim K.-T. (J. Cell Sci. 2007) 3 4 22 64
  3. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. (PMID: 18042622) Miyamoto Y. … Tanoue A. (J. Cell Sci. 2007) 3 4 22 64
  4. Mechanism of CDK5/p25 binding by CDK inhibitors. (PMID: 15689152) Mapelli M. … Musacchio A. (J. Med. Chem. 2005) 3 4 22 64
  5. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PMID: 12691662) Gong X. … Mao Z. (Neuron 2003) 3 4 22 64

Products for CDK5 Gene

  • Addgene plasmids for CDK5

Sources for CDK5 Gene

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