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CDK5 Gene

protein-coding   GIFtS: 74
GCID: GC07M150750

Cyclin-Dependent Kinase 5
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Aliases
for CDK5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 51 2     EC 2.7.11.223 8
Cell Division Protein Kinase 52 3     PSSALRE2
Serine/Threonine-Protein Kinase PSSALRE2 3     Protein Kinase CDK5 Splicing2
Tau Protein Kinase II Catalytic Subunit2 3     CDKN53
TPKII Catalytic Subunit2 3     EC 2.7.118

External Ids:    HGNC: 17741   Entrez Gene: 10202   Ensembl: ENSG000001648857   OMIM: 1238315   UniProtKB: Q005353   

Export aliases for CDK5 gene to outside databases

Previous GC identifers: GC07M148997 GC07M150065 GC07M150142 GC07M150188 GC07M150381 GC07M144563


Summaries
for CDK5 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

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GeneCards Summary for CDK5 Gene:
CDK5 (cyclin-dependent kinase 5) is a protein-coding gene. Diseases associated with CDK5 include aneurysmal bone cysts, and tauopathy. GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and
differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell
cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1,
MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42,
TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and
NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration
and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic
plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and
CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation
loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA,
CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate
neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,
SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at
synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by
phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle
exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating
anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of
p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin
ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating
apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis
producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle
activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes
neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons
protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN
reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)
differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT
(IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional
regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA
synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex.
Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of
TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by
phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1
AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and
contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC
phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May
regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in
dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling

summary for CDK5 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK5 (Cyclin-dependent kinase 5) Gene


Genomic Views
for CDK5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK5 gene promoter:
         p53   p300   C/EBPalpha   PPAR-gamma1   E2F-1   E2F   HOXA5   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK5 promoter sequence
   Search Chromatin IP Primers for CDK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

CDK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150750:  view genomic region     (about GC identifiers)

Start:
 150,750,899 bp from pter      End:
 150,755,617 bp from pter
Size:
 4,719 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,080,438-150,084,591     

Proteins
for CDK5 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 5  
Size: 292 amino acids; 33304 Da
Subunit: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular
complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows
kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate
p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex
with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds
to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes.
Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1.
Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts
with PTK2/FAK1 (By similarity)
Miscellaneous: Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson,
and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis
Selected PDB 3D structures from and Proteopedia for CDK5 (see all 7):
1H4L (3D)        1LFR (3D)        1UNG (3D)        1UNH (3D)        1UNL (3D)        3O0G (3D)    
Secondary accessions: A1XKG3
Alternative splicing: 2 isoforms:  Q00535-1   Q00535-2   

Explore the universe of human proteins at neXtProt for CDK5: NX_Q00535

Explore proteomics data for CDK5 at MOPED

Post-translational modifications: 

  • Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By
    contrast, phosphorylation at Thr-14 inhibits activity1
  • Phosphorylation at Ser-159 is essential for maximal catalytic activity1
  • Ubiquitination2 at Lys20, Lys56, Lys128, Lys141, Lys268
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for CDK5 (Q00535) (see all 20)
     WSAGCIF  LGTPTEE  VVTLWYR  LVFEFCD 


    See CDK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157882.1  NP_004926.1  

    ENSEMBL proteins: 
     ENSP00000419782   ENSP00000297518  
    Reactome Protein details: Q00535

    CDK5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK5 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CDK5
    OriGene Purified Protein for CDK5
    OriGene Protein Over-expression Lysate for CDK5
    OriGene MassSpec for CDK5
    OriGene Custom Protein Services for CDK5
    GenScript Custom Purified and Recombinant Proteins Services for CDK5
    Novus Biologicals CDK5 Proteins
    Novus Biologicals CDK5 Lysates
    Sino Biological Recombinant Protein for CDK5
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDK5
    Cloud-Clone Corp. Proteins for CDK5

    CDK5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK5
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDK5 
    OriGene Antibodies for CDK5
    OriGene Custom Antibody Services for CDK5
    Novus Biologicals CDK5 Antibodies
    Abcam antibodies for CDK5
    Cloud-Clone Corp. Antibodies for CDK5
    ThermoFisher Antibody for CDK5
    LSBio Antibodies in human, mouse, rat for CDK5

    CDK5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK5
    Cloud-Clone Corp. CLIAs for CDK5

    Domains /
    Families
    for CDK5 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 5
    CDK5 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00535

    ProtoNet protein and cluster: Q00535

    UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK5 for domains           About GeneDecksing


    Function
    for CDK5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK5_HUMAN, Q00535
    Function: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and
    differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell
    cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1,
    MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42,
    TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and
    NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration
    and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic
    plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and
    CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation
    loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA,
    CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate
    neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,
    SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at
    synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by
    phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle
    exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating
    anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of
    p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin
    ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating
    apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis
    producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle
    activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes
    neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons
    protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN
    reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs)
    differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT
    (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional
    regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA
    synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex.
    Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of
    TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by
    phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1
    AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and
    contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC
    phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May
    regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in
    dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine),
    1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1
    (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39)
    by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and
    induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35
    available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term
    inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity
    of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived
    neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and
    neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and
    inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents
    neurodegeneration

         Genatlas biochemistry entry for CDK5:
    cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for
    activation with its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with
    cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and
    cAMP regulated and modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant
    increase in CDK5 kinase activity,hyperphosphorylation of tau which reduces tau's ability to associate
    microtubules

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IEA--
    GO:0004672protein kinase activity TAS1639063
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004693cyclin-dependent protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
         
    CDK5 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CDK5:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased Salmonella enterica  
     Increased colony dispersion (i  PARP inhibitor sensitization  Wnt reporter downregulated 

         8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cdk5):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  nervous system 
     no phenotypic analysis  normal  respiratory system 

    CDK5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDK5: Cdk5tm1Kul Cdk5tm1.2Lht

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK5

    miRNA
    Products:            		miRTarBase miRNAs that target CDK5:
    hsa-mir-155-5p (MIRT020734)

    Block miRNA regulation of human, mouse, rat CDK5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CDK5:
    hsa-miR-142-5p hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmid: CDK5 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for CDK5
    Predesigned siRNA for gene silencing in human, mouse, rat CDK5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK5

    Clone
    Products:             		 OriGene clones in human, mouse for CDK5 (see all 12)
    OriGene ORF clones in mouse, rat for CDK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410)
    Sino Biological Human cDNA Clone for CDK5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK5
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK5 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5


    Localization
    for CDK5 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK5_HUMAN, Q00535: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell
    projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse,
    postsynaptic cell membrane, postsynaptic density (By similarity). Note=In axonal growth cone with extension to
    the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35)
    is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level
    of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation.
    Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma
    membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane
    in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this
    attachment and activates CDK5
    CDK5_HUMAN, Q00535: Isoform 2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytoskeleton4
    cytosol4
    extracellular3
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0014069postsynaptic density ISS--

    CDK5 for ontologies           About GeneDecksing


    Pathways & Interactions
    for CDK5 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for CDK5 About   (see all 32)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    		Development Slit Robo signaling0.92
    		Neurophysiological process Receptor mediated axon growth repulsion0.41
    		Cytoskeleton remodeling Slit Robo signaling0.92
    2Alzheimer's disease
    		Alzheimers Disease0.44
    		Alzheimer's disease0.44
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    		Nicotine Activity on Dopaminergic Neurons0.44
    4Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    		Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    		DARPP-32 events0.32
    5Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK5 (see all 8)
        Reelin Pathway (Cajal-Retzius cells)
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling
    GADD45 Pathway
    Cell Cycle Control of Chromosomal Replication

    2 Cell Signaling Technology (CST) Pathways for CDK5
        Cell Cycle / Checkpoint Control
    Neuroscience

    5 GeneGo (Thomson Reuters) Pathways for CDK5
        Neurophysiological process Receptor-mediated axon growth repulsion
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Slit-Robo signaling
    Cytoskeleton remodeling Neurofilaments
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for CDK5 (see all 10)
        DNA damage response
    Nicotine Activity on Dopaminergic Neurons
    BDNF signaling pathway
    IL-6 Signaling Pathway
    Alzheimers Disease


    3 Reactome Pathways for CDK5
        CRMPs in Sema3A signaling
    DARPP-32 events
    Factors involved in megakaryocyte development and platelet production

    1 PharmGKB Pathway for CDK5
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    3 Kegg Pathways  (Kegg details for CDK5):
        Axon guidance
    Alzheimer's disease
    Cocaine addiction


    CDK5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK5: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK5 (Q005351, 2, 3 ENSP000002975184) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1BP465271, 3, ENSP000002288724EBI-1041567,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    MAPTP106362, 3, ENSP000003408204MINT-3974182 I2D: score=2 STRING: ENSP00000340820
    CDK5R1Q150781, 3, ENSP000003184864EBI-1041567,EBI-746189 I2D: score=11 STRING: ENSP00000318486
    CDKN1AP389361, 3, ENSP000002447414EBI-1041567,EBI-375077 I2D: score=1 STRING: ENSP00000244741
    PPP1CAP621362, 3, ENSP000003260314MINT-8286903 I2D: score=1 STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration TAS--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0006468protein phosphorylation ----
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis ----

    CDK5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK5
    Selected ApexBio Compounds for CDK5 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Compounds for CDK5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    7 DrugBank Compounds for CDK5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Indirubin-3'-Monoxime-- --targetinhibitor11752352 10592235
    6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE-- --target--10592235
    Alsterpaullone-- --target--11752352
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    Hymenialdisine-- --targetinhibitor11752352
    Olomoucine-- 101622-51-9targetinhibitor11752352
    SU9516-- --targetinhibitor11752352

    Selected Novoseek inferred chemical compound relationships for CDK5 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 92.4 97 17081516 (5), 19628755 (3), 16802322 (2), 16770643 (2) (see all 54)
    olomoucine 83.5 21 10770290 (2), 18385789 (2), 16815303 (1), 19522735 (1) (see all 10)
    butyrolactone i 75.2 6 15051507 (1), 11882652 (1), 7592534 (1), 11978846 (1)
    purvalanol 68.2 1 16611631 (1)
    glycogen 66.9 71 8627328 (2), 11805297 (2), 16818492 (2), 20211702 (2) (see all 42)
    kenpaullone 64.7 1 15950951 (1)
    threonine 63.9 52 19442718 (1), 19343042 (1), 17697781 (1), 17341134 (1) (see all 28)
    serine 55.4 57 18755796 (1), 19442718 (1), 19343042 (1), 10413323 (1) (see all 33)
    flavopiridol 51.2 2 12941380 (2)
    gamma-butyrolactone 37.3 4 15056716 (1), 18512759 (1), 15369765 (1)



    CDK5 for compounds           About GeneDecksing



    Transcripts
    for CDK5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for CDK5 gene (2 alternative transcripts): 
    NM_001164410.1  NM_004935.3  

    Unigene Cluster for CDK5:

    Cyclin-dependent kinase 5
    Hs.647078  [show with all ESTs]
    Unigene Representative Sequence: BG577212
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485972(uc022apy.1 uc003wir.2 uc003wis.2) ENST00000297518
    ENST00000487703 ENST00000476691 ENST00000469108

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat CDK5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CDK5:
    hsa-miR-142-5p hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmid: CDK5 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for CDK5
    Predesigned siRNA for gene silencing in human, mouse, rat CDK5
    Clone
    Products:             		 OriGene clones in human, mouse for CDK5 (see all 12)
    OriGene ORF clones in mouse, rat for CDK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK5 (NM_001164410)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for CDK5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK5
      QuantiTect SYBR Green Assays in human, mouse, rat CDK5
      QuantiFast Probe-based Assays in human, mouse, rat CDK5

    Additional mRNA sequence: 

    AK026533.1 AY049778.1 AY927560.1 BC005115.1 BT006680.1 CR457041.1 DQ411039.1 L04658.1 
    X66364.1 

    11 DOTS entries:

    DT.319808  DT.97839636  DT.121074391  DT.100022516  DT.121074369  DT.121074491  DT.95132417  DT.95372485 
    DT.95372486  DT.121074488  DT.92466216 

    Selected AceView cDNA sequences (see all 122):

    CA429180 BC005115 AI306490 BV177642 AV709223 CB144453 AA306623 BU529114 
    CF128142 AI086997 AY049778 AK026533 BE673479 AA482510 BX489021 BM727541 
    BF434699 CA431641 BT006680 N52899 NM_004935 BX112764 AA952919 BI859883 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:        -                                         -                 -                                                   
    SP2:                                                  -                 -                                                   
    SP3:        -           -                             -                 -                                                   
    SP4:                                                  -     -                                                               
    SP5:        -                                         -     -           -                                                   


    ECgene alternative splicing isoforms for CDK5

    Expression
    for CDK5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK5 expression in normal human tissues (normalized intensities)      CDK5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCAGCCG
    CDK5 Expression
    About this image


    CDK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    CDK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    CDK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647078

    UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535
    Tissue specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level).
    Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK5: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for CDK5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK5
    QuantiTect SYBR Green Assays in human, mouse, rat CDK5
    QuantiFast Probe-based Assays in human, mouse, rat CDK5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5

    Orthologs
    for CDK5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdk51 , 5 cyclin-dependent kinase 51, 5 90.87(n)1
    99.66(a)1    		   5 (11.73 cM)5
    125681  NM_007668.31  NP_031694.11 
     244182505 
    chicken
    (Gallus gallus)    		 Aves CDK51 cyclin-dependent kinase 5 83.56(n)
    97.26(a)    		   100190948  NM_001135786.1  NP_001129258.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.672 Xenopus laevis neuronal cyclin-dependent kinase 5 (cdk5) more 81.87(n)    U24397.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk52 cyclin-dependent protein kinase 5 78.02(n)   65234  AF203736.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdk51 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Cyclin-dependent kinase 51    		 79(a)
    (best of 2)3
    70.72(n)1
    79.17(a)1    		   2 52A133
    367271  NM_057732.31  NP_477080.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea H01G02.23
    cdk-51    		 serine/threonine kinase (2 domains)3
    cdk-51    		 35(a)3
    64.7(n)1
    74.65(a)1    		   IV(11798872-11801260)3
    1767741  NM_067382.71  NP_499783.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PHO851 PHO85 60.47(n)
    58.6(a)    		   856076   NP_015294.1 


    ENSEMBL Gene Tree for CDK5 (if available)
    TreeFam Gene Tree for CDK5 (if available)

    Paralogs
    for CDK5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CDK5 gene
    CDK182  CDK142  CDK162  CDK172  CDK152  
    Selected SIMAP similar genes for CDK5 using alignment to 2 protein entries:     CDK5_HUMAN (see all proteins) (see all similar genes):
    CDK3    CDK18    CDK16    CDK17    PCTK1    CDK1
    CDC2    PCTK3    DKFZp686L20222    CDK15    CDK14    CDC2L1
    CDC2L2    CDK11A    CDK11B    CDK7    CCRK    CDK6

    CDK5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK5
    PGOHUM00000249786


    Genomic Variants
    for CDK5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDK5 (see all 81)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1859225671,2
    		C--150750511(+) CATATA/CTTTGG 2 -- int10--------
    rs125375231,2
    		C,H--150750566(+) TGAGGG/AAAAGG 2 -- int13Minor allele frequency- A:0.22NA EA 242
    rs1449822501,2
    		--150750961(+) AATTCA/GGGCTC 2 -- ut310--------
    rs1168631651,2
    		F--150750978(+) CCCACC/TCCGGC 2 -- ut311Minor allele frequency- T:0.01EA 120
    rs92781,2
    		C,F--150750980(-) CAGCCG/AGGGTG 2 -- ut31 ese311Minor allele frequency- A:0.14NA MN WA 1090
    rs20694611,2
    		C,F--150750981(-) CCAGCC/TGGGGT 2 -- ut31 ese36Minor allele frequency- T:0.00NA MN 452
    rs350514461,2
    		F--150751010(-) TGGTGC/TGCTGT 2 -- ut315Minor allele frequency- T:0.01MN 404
    rs796273161,2
    		C--150751081(-) CCCCCA/GGCCTC 2 -- ut310--------
    rs20694601,2
    		C,F--150751091(-) GGCCCC/TGGGAC 2 -- ut31 ese37Minor allele frequency- T:0.01NA MN EA 644
    rs115416021,2
    		C--150751132(-) GCCCTG/TCAGCA 4 L syn12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for CDK5 (150750899 - 150755617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CDK5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7546n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv889465CNV Loss21882294
    nsv526410CNV Loss19592680
    nsv889471CNV Loss21882294
    dgv7545n71CNV Loss21882294
    nsv831188CNV Loss17160897
    nsv889476CNV Loss21882294
    nsv524928CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK5
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK5

    Disorders / Diseases
    for CDK5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 123831    OMIM disorders: --

    Selected diseases for CDK5 (see all 59):    About MalaCards
    aneurysmal bone cysts    tauopathy    transient cerebral ischemia    miller-dieker syndrome
    multiple system atrophy    differentiating neuroblastoma    toxic encephalopathy    progressive supranuclear palsy
    brain disease    motor neuron disease    ganglioglioma    inclusion body myositis
    lissencephaly    hereditary spastic paraplegia    myositis    ischemia
    dyslexia    lateral sclerosis    herpes simplex    amyotrophic lateral sclerosis

    4 diseases from the University of Copenhagen DISEASES database for CDK5:
    Alzheimer's disease     Amyotrophic lateral sclerosis     Toxic encephalopathy     Lissencephaly

    CDK5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CDK5 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 78.2 14 8870824 (2), 9666145 (1), 12719630 (1), 19154537 (1) (see all 10)
    alzheimers disease 75.3 69 9666145 (2), 18350355 (2), 16413130 (2), 15917097 (2) (see all 43)
    tauopathies 74.9 3 17113760 (2), 17908241 (1)
    paired helical filament 74.5 8 9666145 (1), 15975083 (1), 8870824 (1), 11065131 (1) (see all 5)
    neurodegeneration 71.2 40 16932754 (4), 15009631 (2), 14673208 (2), 17932412 (2) (see all 26)
    neurodegenerative diseases 71.1 66 17979810 (4), 16600851 (2), 17003520 (2), 15135890 (2) (see all 36)
    amyotrophic lateral sclerosis 57.5 22 14673208 (2), 9596352 (2), 11464850 (2), 10509378 (1) (see all 14)
    senile plaques 43.9 2 12719630 (1), 14681576 (1)
    brain diseases 42.8 3 17241267 (1), 15917097 (1)
    parkinson disease 38.6 13 9255390 (2), 20504213 (2), 19075597 (1), 7485409 (1) (see all 6)

    Genetic Association Database (GAD): CDK5
    Human Genome Epidemiology (HuGE) Navigator: CDK5 (52 documents)

    Export disorders for CDK5 gene to outside databases

    Publications
    for CDK5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CDK5 gene, integrated from 10 sources (see all 643):
    (articles sorted by number of sources associating them with CDK5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    2. Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. (PubMed id 10500146)1, 2, 9 Sharma P.... Pant H.C. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PubMed id 17591690)1, 2, 9 Lee J.-H.... Kim K.-T. (J. Cell Sci. 2007)
    4. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PubMed id 12691662)1, 2, 9 Gong X.... Mao Z. (Neuron 2003)
    5. Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. (PubMed id 18350355)1, 4, 9 Arias-VA!squez A....van Duijn C.M. (J. Neurol. 2008)
    6. Structure and regulation of the CDK5-p25(nck5a) complex. (PubMed id 11583627)1, 2, 9 Tarricone C....Musacchio A. (Mol. Cell 2001)
    7. CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. (PubMed id 20213743)1, 2, 9 Lee C.-H....Lu P.-J. (J. Cell. Biochem. 2010)
    8. Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. (PubMed id 19343042)1, 4, 9 Choi H.S....Kim Y.H. (J. Hum. Genet. 2009)
    9. No association of CDK5 genetic variants with Alzheimer's disease risk. (PubMed id 19615060)1, 4, 9 VA!zquez-Higuera J.L....Combarros O. (BMC Med. Genet. 2009)
    10. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. (PubMed id 18042622)1, 2, 9 Miyamoto Y.... Tanoue A. (J. Cell Sci. 2007)

    External Searches for CDK5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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    NCBI Bookshelf
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    Genome Databases showing CDK5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1020 HGNC: 1774 AceView: CDK5 Ensembl:ENSG00000164885 euGenes: HUgn1020
    ECgene: CDK5 Kegg: 1020 H-InvDB: CDK5

    Other Databases showing CDK5 gene

    (According to HUGE)
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    Specialized Databases showing CDK5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CDK5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for CDK5 gene:
    Search GeneIP for patents involving CDK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse Kits and Assays available from EMD Millipore
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK5
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