CDK5 Gene
protein-coding GIFtS : 74 GCID: GC07 M150750
Cyclin-Dependent Kinase 5
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Aliasesfor CDK5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Cyclin-Dependent Kinase 5 1 2 EC 2.7.11.223 8 Cell Division Protein Kinase 52 3 PSSALRE2 Serine/Threonine-Protein Kinase PSSALRE2 3 Protein Kinase CDK5 Splicing2 Tau Protein Kinase II Catalytic Subunit2 3 CDKN53 TPKII Catalytic Subunit2 3 EC 2.7.118
Export aliases for CDK5 gene to outside databases Previous GC identifers: GC07M148997 GC07M150065 GC07M150142 GC07M150188 GC07M150381 GC07M144563
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Summariesfor CDK5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Summary for CDK5 Gene: CDK5 (cyclin-dependent kinase 5) is a protein-coding gene. Diseases associated with CDK5 include aneurysmal bone cysts tauopathy related super-pathways are Development Slit-Robo signaling and Parkinson's disease . GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding . An important paralog of this gene is CDK18 . UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 Function : Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiationand may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling summary
for CDK5 Gene: Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression throughthe cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdkgenes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Followingextracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin Dand phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F inducestranscription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin Ecomplexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/Mphase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiationof mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced bymolecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdksis essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead toCdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potentialtargets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeuticstrategies that block Cdk activity are unlikely to selectively target tumor cells. Gene Wiki entry for CDK5 (Cyclin-dependent kinase 5) Gene
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Genomic Viewsfor CDK5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.2 NT_007914.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CDK5 gene promoter:p53 p300 C/EBPalpha PPAR-gamma1 E2F-1 E2F HOXA5 PPAR-gamma2 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for CDK5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36 CDK5 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M150750: view genomic region
(about GC identifiers )
Start: 150,750,899 bp from pter End:
150,755,617 bp from pter
Size: 4,719 bases Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 150,080,438-150,084,591
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Proteinsfor CDK5 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 See
protein sequence )Recommended Name: Size : 292 amino acids; 33304 DaSubunit : Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecularcomplex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity)
Subcellular location : Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection,lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Co-localizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5
Subcellular location : Isoform 2: NucleusMiscellaneous : Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, andNiemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis
6/7 PDB 3D structures from (see all 7 ):1H4L (3D) 1LFR (3D) 1UNG (3D) 1UNH (3D) 1UNL (3D) 3O0G (3D) Secondary accessions : A1XKG3Alternative splicing : 2 isoforms : Q00535-1 Q00535-2 Explore the universe of human proteins at neXtProt for CDK5: NX_Q00535 Explore proteomics data for CDK5 at MOPED Post-translational modifications:
UniProtKB: Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity
UniProtKB: Phosphorylation at Ser-159 is essential for maximal catalytic activity View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q00535 4/20 DME Specific Peptides for CDK5 (Q00535 ) (see all 20 )CDK5 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (2 alternative transcripts): NP_001157882.1 NP_004926.1 ENSEMBL proteins: ENSP00000419782 ENSP00000297518 Reactome Protein details: Q00535 Human Recombinant Protein Products for CDK5: Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19 ): About this table
About GeneDecksing CDK5 Antibody Products: Assay Products for CDK5:
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Protein
Domains /for CDK5 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: CDK: Cyclin-dependent kinases IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 5 CDK5 subfamily 5 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q00535 ProtoNet protein and cluster: Q00535
UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity : Contains 1 protein kinase domainAbout GeneDecksing
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Functionfor CDK5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: CDK5_HUMAN, Q00535 Function : Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiationand may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine),1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration
Genatlas biochemistry entry for CDK5 cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for activation with its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and cAMP regulated and modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant increase in CDK5 kinase activity,hyperphosphorylation of tau which reduces tau's ability to associate microtubules Enzyme Numbers (IUBMB): EC 2.7.11.22 1 2 EC 2.7.11 2 Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002039 p53 binding
IEA -- GO:0004672 protein kinase activity
TAS 1639063 GO:0004674 protein serine/threonine kinase activity
TAS -- GO:0004693 cyclin-dependent protein serine/threonine kinase activity
ISS -- GO:0004713 protein tyrosine kinase activity
-- --
About GeneDecksing Phenotypes: 7 GenomeRNAi human phenotypes for CDK5 :8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cdk5) :About GeneDecksing Animal Models: Cdk5 tm1Kul Cdk5 tm1.2Lht In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5
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Pathways & Interactionsfor CDK5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for CDK5 About (see all 34 ) See pathways by source SuperPath Contained pathways About 1 Development Slit-Robo signaling 2 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 3 Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics 4 Signaling by GPCR 5 Axon guidance
Pathways by source See SuperPaths Show all pathways 5 5/8 (see all 8 )2 5 5/10 (see all 10 )5/10 (see all 10 )1 CDK5 3 (Kegg details for CDK5) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK5 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/136 Interacting proteins for CDK5 (Q00535 1 , 2 , 3 ENSP00000297518 4 via UniProtKB, MINT, STRING , and/or I2D (see all 136 )Interactant Interaction Details GeneCard External ID(s) CDKN1B P46527 1 , 3 ENSP00000228872 4 EBI-1041567,EBI-519280 I2D:
score=3 STRING: ENSP00000228872 MAPT P10636 2 , 3 ENSP00000340820 4 MINT-3974182 I2D:
score=2 STRING: ENSP00000340820 CDK5R1 Q15078 1 , 3 ENSP00000318486 4 EBI-1041567,EBI-746189 I2D:
score=11 STRING: ENSP00000318486 PPP1CA P62136 2 , 3 ENSP00000326031 4 MINT-8286903 I2D:
score=1 STRING: ENSP00000326031 CRELD2 Q6UXH1 2 , 3 MINT-8251466 I2D:
score=1
About this table Gene Ontology (GO): 5/76 biological process terms (GO ID links to tree view) (see all 76 ): About this table
About GeneDecksing
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Drugs & Compoundsfor CDK5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for CDK5
Compounds for CDK5 available from Tocris Bioscience About this table Compound Action
CAS
# SU 9516 Potent cdk2 inhibitor [377090-84-1] Purvalanol A Cyclin-dependent kinase inhibitor [212844-53-6] Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor [872573-93-8] Purvalanol B Cyclin-dependent kinase inhibitor [212844-54-7] Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 [142273-20-9]
2 HMDB Compounds for CDK5 About this table 7 DrugBank Compounds for CDK5 About this table 10/48 Novoseek inferred chemical compound relationships for CDK5 gene (see all 48 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
roscovitine
92.4
97
17081516 (5), 19628755 (3), 16802322 (2), 16770643 (2) (see
all 54 )
olomoucine
83.5
21
10770290 (2), 18385789 (2), 16815303 (1), 19522735 (1) (see
all 10 )
butyrolactone i
75.2
6
15051507 (1), 11882652 (1), 7592534 (1), 11978846 (1)
purvalanol
68.2
1
16611631 (1)
glycogen
66.9
71
8627328 (2), 11805297 (2), 16818492 (2), 20211702 (2) (see
all 42 )
kenpaullone
64.7
1
15950951 (1)
threonine
63.9
52
19442718 (1), 19343042 (1), 17697781 (1), 17341134 (1) (see
all 28 )
serine
55.4
57
18755796 (1), 19442718 (1), 19343042 (1), 10413323 (1) (see
all 33 )
flavopiridol
51.2
2
12941380 (2)
gamma-butyrolactone
37.3
4
15056716 (1), 18512759 (1), 15369765 (1)
CDK5
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Transcriptsfor CDK5 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CDK5 gene (2 alternative transcripts): NM_001164410.1 NM_004935.3 Unigene Cluster for CDK5:
Cyclin-dependent kinase 5 Hs.647078 [show with all ESTs ] Unigene Representative Sequence: BG577212 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000485972 (uc022apy.1 uc003wir.2 uc003wis.2 ) ENST00000297518 ENST00000487703 ENST00000476691 ENST00000469108 Primer CDK5 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AK026533.1 AY049778.1 AY927560.1 BC005115.1 BT006680.1 CR457041.1 DQ411039.1 L04658.1 X66364.1
11 DOTS entries : DT.319808 DT.97839636
DT.121074391 DT.100022516 DT.121074369 DT.121074491 DT.95132417 DT.95372485 DT.95372486 DT.121074488 DT.92466216 24/122 AceView cDNA sequences (see all 122 ):
AI306490 BT006680 BF434699 BV177642 N52899 AY049778 AV709223 CB144453 AA482510 AA306623 NM_004935 CF128142 AA952919 BE673479 BU529114 BC005115 AK026533 AI086997 CA431641 CA429180 BX112764 BX489021 BM727541 BM040737 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b SP1 : - - - SP2 : - - SP3 : - - - - SP4 : - - SP5 : - - - -
ECgene alternative splicing isoforms for CDK5
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Expression for CDK5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CDK5 expression in normal human tissues
(normalized intensities) CDK5 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: TGGTCAGCCGAbout this image
CDK5 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/7 selected tissues (see all 7 ) fully expand See CDK5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CDK5 SOURCE GeneReport for Unigene cluster: Hs.647078 UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 Tissue specificity : Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2has only been detected in testis, skeletal muscle, colon, bone marrow and ovary SABiosciences Expression via Pathway-Focused PCR Arrays including CDK5 : Primer CDK5 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5
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Orthologsfor CDK5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CDK5 gene from 7/19 species (see all 19 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Cdk51 5
cyclin-dependent kinase 51, 5
90.87(n) 1 99.66(a) 1
5 (11.73 cM) 5 12568 1 NM_007668.3 1 NP_031694.1 1 24418250 5
chicken Aves CDK51
cyclin-dependent kinase 5
83.56(n) 97.26(a)
100190948 NM_001135786.1 NP_001129258.1
African clawed frog Amphibia Xl.672
Xenopus laevis neuronal cyclin-dependent kinase 5 (cdk5) more
81.87(n)
U24397.1
zebrafish Actinopterygii cdk52
cyclin-dependent protein kinase 5
78.02(n)
65234 AF203736.1
fruit fly Insecta Cdk51 3
protein amino acid phosphorylation proteinmore 3 1
79(a) 3 70.72(n) 1 79.17(a) 1
2 52A133 36727 1 NM_057732.3 1 NP_477080.1 1
worm Secernentea H01G02.23 1
serine/threonine kinase (2 domains)3 1
35(a) 3 64.7(n) 1 74.65(a) 1
IV(11798872-11801260)3 176774 1 NM_067382.6 1 NP_499783.1 1
baker's yeast Saccharomycetes PHO851
Pho85p
60.23(n) 58.25(a)
856076 NP_015294.1
ENSEMBL Gene Tree for CDK5 (if available)TreeFam Gene Tree for CDK5 (if available)
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Paralogsfor CDK5 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CDK5 gene CDK18 2 CDK6 2 CDK15 2 CDK1 2 CDK4 2 CDK3 2 CDK14 2 CDK16 2 CDK2 2 CDK17 2 18/63 SIMAP similar genes for CDK5 using alignment to 2 protein entries: CDK5_HUMAN (see all proteins )
(see all similar genes ):CDK3 CDK18 CDK16 CDK17 PCTK1 CDK1 CDC2 PCTK3 DKFZp686L20222 CDK15 CDK14 CDC2L1 CDC2L2 CDK11A CDK11B CDK7 CCRK CDK6 About GeneDecksing 1 Pseudogenes.org Pseudogene for CDK5 PGOHUM00000249786
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Genomic Variantsfor CDK5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 7 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CDK5 (150750899 - 150755617 bp)
Structural Variations Database of Genomic Variants (DGV) 9 variations for CDK5 : About this table SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor CDK5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 123831
OMIM disorders : --20/57 (see all 57 ): About MalaCards aneurysmal bone cysts tauopathy multiple system atrophy miller-dieker syndrome transient cerebral ischemia differentiating neuroblastoma ganglioglioma toxic encephalopathy progressive supranuclear palsy inclusion body myositis brain disease lateral sclerosis amyotrophic lateral sclerosis hereditary spastic paraplegia myositis ischemia lissencephaly herpes simplex motor neuron disease paraplegia 4 diseases from the University of Copenhagen DISEASES database for CDK5 :Alzheimer's disease Amyotrophic lateral sclerosis Toxic encephalopathy Lissencephaly Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/36 Novoseek inferred disease relationships for CDK5 gene (see all 36 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
neurofibrillary tangles
78.2
14
8870824 (2), 9666145 (1), 12719630 (1), 19154537 (1) (see
all 10 )
alzheimers disease
75.3
69
9666145 (2), 18350355 (2), 16413130 (2), 15917097 (2) (see
all 43 )
tauopathies
74.9
3
17113760 (2), 17908241 (1)
paired helical filament
74.5
8
9666145 (1), 15975083 (1), 8870824 (1), 11065131 (1) (see
all 5 )
neurodegeneration
71.2
40
16932754 (4), 15009631 (2), 14673208 (2), 17932412 (2) (see
all 26 )
neurodegenerative diseases
71.1
66
17979810 (4), 16600851 (2), 17003520 (2), 15135890 (2) (see
all 36 )
amyotrophic lateral sclerosis
57.5
22
14673208 (2), 9596352 (2), 11464850 (2), 10509378 (1) (see
all 14 )
senile plaques
43.9
2
12719630 (1), 14681576 (1)
brain diseases
42.8
3
17241267 (1), 15917097 (1)
parkinson disease
38.6
13
9255390 (2), 20504213 (2), 19075597 (1), 7485409 (1) (see
all 6 )
Genetic Association Database (GAD): CDK5 Human Genome Epidemiology (HuGE) Navigator: CDK5 (52 documents) Export disorders for CDK5 gene to outside databases
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Publicationsfor CDK5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CDK5 gene, integrated from 9 sources (see all 634 ):(articles sorted by number of sources associating them with CDK5) Utopia : connect your pdf to the dynamic
A family of human cdc2-related protein kinases. (PubMed id 1639063) 1 , 2 , 3(1992) Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. (PubMed id 10500146) 1 , 2 , 9(1999) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PubMed id 17591690) 1 , 2 , 9(2007) Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PubMed id 12691662) 1 , 2 , 9(2003) Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. (PubMed id 18350355) 1 , 4, 9(2008) Structure and regulation of the CDK5-p25(nck5a) complex. (PubMed id 11583627) 1 , 2 , 9(2001) CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. (PubMed id 20213743) 1 , 2 , 9(2010) Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. (PubMed id 19343042) 1 , 4, 9(2009) No association of CDK5 genetic variants with Alzheime r's disease risk. (PubMed id 19615060) 1 , 4, 9(2009) Cdk5 regulates differentiation of oligodendrocyte pre cursor cells through the direct phosphorylation of paxillin. (PubMed id 18042622) 1 , 2 , 9(2007)
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External Searches for CDK5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CDK5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CDK5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CDK5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CDK5 gene: CDK5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CDK5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK5 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for CDK5
Tocris compounds for CDK5
Recombinant Protein for CDK5
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK5
ThermoFisher Antibody for CDK5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CDK5
LSBio Antibodies in human mouse rat
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summary
for 
and Proteopedia 
for CDK5 (
