Aliases for CDK5 Gene
Aliases for CDK5 Gene
External Ids for CDK5 Gene
- HGNC: 1774
- Entrez Gene: 1020
- Ensembl: ENSG00000164885
- OMIM: 123831
- UniProtKB: Q00535
Previous GeneCards Identifiers for CDK5 Gene
- GC07M148997
- GC07M150065
- GC07M150142
- GC07M150188
- GC07M150381
- GC07M150750
- GC07M144563
Summaries for CDK5 Gene
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This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
GeneCards Summary for CDK5 Gene
CDK5 (Cyclin Dependent Kinase 5) is a Protein Coding gene. Diseases associated with CDK5 include Lissencephaly 7 With Cerebellar Hypoplasia and Lissencephaly. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK3.
UniProtKB/Swiss-Prot for CDK5 Gene
-
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
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Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.
Additional gene information for CDK5 Gene
- Monarch Initiative
- Search for CDK5 at DataMed
- Search for CDK5 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5 Gene
Genomics for CDK5 Gene
GeneHancer (GH) Regulatory Elements for CDK5 Gene
- Top Transcription factor binding sites by QIAGEN in the CDK5 gene promoter:
Regulatory Element Products
Genomic Locations for CDK5 Gene
- chr7:151,053,812-151,058,530
- (GRCh38/hg38)
- Size:
- 4,719 bases
- Orientation:
- Minus strand
- chr7:150,750,899-150,755,617
- (GRCh37/hg19)
Genomic View for CDK5 Gene
- Cytogenetic band:
-
- 7q36.1 by Ensembl
- 7q36.1 by Entrez Gene
- 7q36.1 by HGNC


RefSeq DNA sequence for CDK5 Gene
Proteins for CDK5 Gene
-
Protein details for CDK5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00535-CDK5_HUMAN
- Recommended name:
- Cyclin-dependent-like kinase 5
- Protein Accession:
- Q00535
- A1XKG3
Protein attributes for CDK5 Gene
- Size:
- 292 amino acids
- Molecular mass:
- 33304 Da
- Quaternary structure:
-
- Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity). The complex p35/CDK5 interacts with CLOCK. Interacts with HTR6 (By similarity).
- Miscellaneous:
-
- Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.
Three dimensional structures from OCA and Proteopedia for CDK5 Gene
Protein Expression for CDK5 Gene
Selected DME Specific Peptides for CDK5 Gene
- Q00535:
-
- LVFEFCD
- NIVRLHD
- IFRLLGTP
- GELKLADFGLA
- DFGLARA
- DVLHSDKKLTLVFE
- SLVNVVPKLNATGRDLLQNLLKCNPVQRI
- WSAGCIF
- RISAEEAL
- VVTLWYR
- LADFGLA
- VLHRDLK
- DFGLARAFG
- GRPLFPG
- LGTPTEE
- DDEGVPSSALREICLLKELKHKNIVRL
- CYSAEVVTLWYRPPDVLFGAKLY
- HRDLKPQN
- DQDLKKY
- IGEGTYG
Post-translational modifications for CDK5 Gene
- Phosphorylation at Ser-159 is essential for maximal catalytic activity.
- Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.
- Ubiquitination at posLast=2020, Lys128, posLast=141141, and posLast=268268
Other Protein References for CDK5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for CDK5 (CDK5)
- Novus Biologicals Antibodies for CDK5
-
Abcam antibodies for CDK5
-
Cloud-Clone Corp. Antibodies for CDK5
- Invitrogen Antibodies for CDK5
- antibodies-online: Search results for 241 available CDK5 Antibodies ranked by validation data
- Compare Top CDK5 Antibodies
-
Recommended
- 1 IHC (p) Antibody (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 123 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 124 WB Antibodies (anti-mouse)
- 1 IF Antibody (anti-human)
- 2 IP Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 201 WB Antibodies (anti-human)
- GeneTex CDK5 antibody for CDK5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK5
Protein Products
-
OriGene Purified Proteins for CDK5
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK5
- Origene Custom Protein Services for CDK5
- Sino Biological Recombinant Proteins for CDK5
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for CDK5
-
Cloud-Clone Corp. Proteins for CDK5
- Search GeneTex for Proteins for CDK5
-
Abcam proteins for CDK5
Assay Products
- Cell Signaling Technology (CST) Sandwich ELISA Kits for CDK5 (CDK5)
-
Cloud-Clone Corp. Assay Kits for CDK5
Domains & Families for CDK5 Gene
Gene Families for CDK5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for CDK5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q00535UniProtKB/Swiss-Prot:
CDK5_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK5 Gene
Molecular function for CDK5 Gene
- GENATLAS Biochemistry:
- cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle cells,associating for activation with its regulatory subunit p35 (CDK5R1) to form one of the two main tau-kinases,complexing with cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S transition,phosphorylating DARRP2 dopamine and cAMP regulated and modulating dopamine signaling,associating with p25,a truncated form of p35 with a resultant increase in CDK5 kinase activity,hyperphosphorylation of tau which reduces taus ability to associate microtubules
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration.
- UniProtKB/Swiss-Prot Function:
- Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Enzyme Numbers (IUBMB) for CDK5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002039 | p53 binding | IEA | -- |
GO:0004672 | protein kinase activity | TAS | 1639063 |
GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA,TAS | -- |
GO:0005176 | ErbB-2 class receptor binding | ISS | -- |
Phenotypes for CDK5 Gene
- MGI mutant phenotypes for CDK5:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CDK5:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Increased transferrin (TF) endocytosis
- Decreased viability
- Wnt reporter downregulated
- Decreased Salmonella enterica Typhimurium invasion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased shRNA abundance
- Increased viability with TRAIL
- Decreased substrate adherent cell growth
- Increased Nanog expression
- Decreased viability with poly (ADPa89ribose)a89polymerasea891 (PARP) inhibitor
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5 gene
- Search ViGene Biosciences for CDK5
CRISPR Products
-
OriGene CRISPR knockouts for CDK5
- genomics-online: gRNA clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
- Applied Biological Materials CRISPR for CDK5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK5
- GenScript: Design CRISPR guide RNA sequences for CDK5
miRNA for CDK5 Gene
- miRTarBase miRNAs that target CDK5
miRNA Products
- Search ViGene Biosciences for CDK5
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for CDK5
- Browse OriGene Inhibitory RNA Products For CDK5
- genomics-online: shRNA clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CDK5
- Applied Biological Materials Clones for CDK5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CDK5
Cell Line Products
-
Horizon Cell Lines for CDK5
-
ViGene Biosciences adenoviral particle packaged cDNA for CDK5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5 gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for CDK5 Gene
Localization for CDK5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK5 Gene
- Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium. Cell projection, growth cone. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. {ECO:0000250}.
- Isoform 2: Nucleus.
- Cell Junctions (3)
- Nucleus (3)
- Plasma membrane (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS,IBA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | ISS | -- |
GO:0005829 | cytosol | TAS,IBA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for CDK5 Gene
Pathways by source for CDK5 Gene
1 GeneTex pathway for CDK5 Gene
2 Cell Signaling Technology pathways for CDK5 Gene
11 BioSystems pathways for CDK5 Gene
18 Reactome pathways for CDK5 Gene
1 PharmGKB pathway for CDK5 Gene
3 KEGG pathways for CDK5 Gene
5 GeneGo (Thomson Reuters) pathways for CDK5 Gene
2 R&D Systems pathways for CDK5 Gene
8 Qiagen pathways for CDK5 Gene
Interacting Proteins for CDK5 Gene
SIGNOR curated interactions for CDK5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | TAS | 17491008 |
GO:0001764 | neuron migration | TAS | 21473899 |
GO:0001963 | synaptic transmission, dopaminergic | IEA | -- |
GO:0006468 | protein phosphorylation | TAS | 17491008 |
GO:0006886 | intracellular protein transport | IEA | -- |
Drugs & Compounds for CDK5 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Alvocidib | Experimental, Investigational | Pharma | Target, inhibitor | Pan-cdk inhibitor, Kinase Inhibitors | 60 | |
Olomoucine | Experimental | Pharma | Target, inhibitor | 0 | ||
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE | Experimental | Pharma | Target | 0 | ||
Alsterpaullone | Experimental | Pharma | Target | 0 | ||
Hymenialdisine | Experimental | Pharma | Target, inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(5) Tocris Compounds for CDK5 Gene
Compound | Action | Cas Number |
---|---|---|
(R)-CR8 | Dual cdk1/cdk5 inhibitor; also inhibits CK1 | 294646-77-8 |
Arcyriaflavin A | Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) | 118458-54-1 |
AZD 5438 | Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor | 602306-29-6 |
Olomoucine | Cyclin-dependent kinase inhibitor | 101622-51-9 |
SU 9516 | Potent cdk2 inhibitor | 377090-84-1 |
(13) ApexBio Compounds for CDK5 Gene
Compound | Action | Cas Number |
---|---|---|
(R)-DRF053 dihydrochloride | cdk/CK1 inhibitor,potent and ATP-competitive | 1241675-76-2 |
AT7519 | Multi-CDK inhibitor | 844442-38-2 |
BS-181 HCl | CDK7 inhibitor,highly selective | 1397219-81-6 |
CDK inhibitor II | 1269815-17-9 | |
Dinaciclib (SCH727965) | Potent CDK inhibitor | 779353-01-4 |
Flavopiridol | Pan-cdk inhibitor | 146426-40-6 |
Kenpaullone | 142273-20-9 | |
NSC 693868 | 40254-90-8 | |
NVP-LCQ195 | CDK1/CDK2/CDK5 inhibitor | 902156-99-4 |
PF 4800567 hydrochloride | 1391052-28-0 | |
PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
Roscovitine (Seliciclib,CYC202) | CDK inhibitor,potent and selective | 186692-46-6 |
TMCB | 905105-89-7 |
Transcripts for CDK5 Gene
mRNA/cDNA for CDK5 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (122) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDK5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK5
- genomics-online: gRNA clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
- Applied Biological Materials CRISPR for CDK5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK5
- GenScript: Design CRISPR guide RNA sequences for CDK5
miRNA Products
- Search ViGene Biosciences for CDK5
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for CDK5
- Browse OriGene Inhibitory RNA Products For CDK5
- genomics-online: shRNA clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK5 gene
Clone Products
- Sino Biological Human cDNA Clone for CDK5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CDK5
- Applied Biological Materials Clones for CDK5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CDK5
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: | - |
Expression for CDK5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK5 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDK5 Gene:
CDK5SOURCE GeneReport for Unigene cluster for CDK5 Gene:
Hs.647078mRNA Expression by UniProt/SwissProt for CDK5 Gene:
Q00535-CDK5_HUMANEvidence on tissue expression from TISSUES for CDK5 Gene
- Nervous system(4.9)
- Lung(4.3)
- Kidney(2.2)
- Adrenal gland(2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK5 Gene
- ectoderm
- mesoderm
- integumentary
- lymphatic
- nervous
- skeletal muscle
- skeleton
- brain
- cerebellum
- cheek
- chin
- face
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
- hair
- lymph node
- lymph vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
Primer Products
-
OriGene qPCR primer pairs for CDK5
-
OriGene qPCR primer pairs and template standards for CDK5
- genomics-online: primer clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
No data available for mRNA differential expression in normal tissues for CDK5 Gene
Orthologs for CDK5 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CDK5 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CDK5 33 34 |
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||
dog (Canis familiaris) |
Mammalia | CDK5 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Cdk5 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cdk5 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CDK5 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CDK5 33 34 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk5 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.67 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | cdk5 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005772 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Cdk5 35 33 34 |
|
||
CG6800 35 |
|
|
|||
worm (Caenorhabditis elegans) |
Secernentea | cdk-5 33 34 |
|
||
H01G02.2 35 |
|
|
|||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGL242C 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PHO85 33 34 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D11990g 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1504 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU07580 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pef1 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2120 33 |
|
- Species where no ortholog for CDK5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CDK5 Gene
(63) SIMAP similar genes for CDK5 Gene using alignment to 2 proteins:
- CDK3
- CDK18
- PCTK1
- CDK17
- CDK16
- CDK1
- CDC2
- PCTK3
- DKFZp686L20222
- CDK15
- CDK14
- CDK11B
- CDK11A
- CDC2L2
- CDC2L1
- CDK7
- CDK6
- CCRK
- CDK2
- CDK20
- CDK10
- CDK4
- MAK
- CDK12
- CDKL1
- CDKL2
- DKFZp686O0215
- DKFZp434B079
- CDKL3
- CDKL4
- DKFZp434M058
- MAPK3
- CDK9
- MAPK1
- MAPK10
- CSNK2A2
- MAPK4
- MAPK15
- GSK3A
- DKFZp686D0638
- CDK8
- MAPK14
- NEK3
- MAPK11
- NLK
- CSNK2A1
- MAPK7
- CSNK2A3
- MAPK13
- CDK19
- MAPK8
- MAPK9
- GSK3B
- MOK
- AURKA
- STK17A
- STK36
- AURKB
- MAPK12
- NEK5
- DYRK4
- DKFZp686M02159
- AURKC
Pseudogenes.org Pseudogenes for CDK5 Gene
Variants for CDK5 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs786205164 | pathogenic, Lissencephaly 7 with cerebellar hypoplasia | 151,055,276(-) | C/T | splice_donor_variant | |
rs62490285 | likely-benign, not specified | 151,054,284(-) | C/A/G/T | coding_sequence_variant, synonymous_variant | |
rs76486938 | uncertain-significance, not specified | 151,054,474(-) | G/A | intron_variant | |
rs1000324881 | -- | 151,054,558(-) | C/G | intron_variant | |
rs1000675589 | -- | 151,054,779(-) | G/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv11724n54 | CNV | loss | 21841781 |
dgv3695n106 | OTHER | inversion | 24896259 |
dgv6756n100 | CNV | gain | 25217958 |
nsv1067934 | OTHER | inversion | 25765185 |
nsv1151906 | OTHER | inversion | 26484159 |
nsv524928 | CNV | gain | 19592680 |
nsv526410 | CNV | loss | 19592680 |
nsv831188 | CNV | loss | 17160897 |
nsv951648 | CNV | deletion | 24416366 |
Additional Variant Information for CDK5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5 Gene
Disorders for CDK5 Gene

(14) MalaCards diseases for CDK5 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
lissencephaly 7 with cerebellar hypoplasia |
|
|
lissencephaly |
|
|
ischemia |
|
|
aneurysmal bone cysts |
|
|
lissencephaly with cerebellar hypoplasia |
|
|
UniProtKB/Swiss-Prot
CDK5_HUMAN- Lissencephaly 7, with cerebellar hypoplasia (LIS7) [MIM:616342]: A form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS7 patients manifest lack of psychomotor development, facial dysmorphism, arthrogryposis, and early-onset intractable seizures resulting in death in infancy. {ECO:0000269 PubMed:25560765}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CDK5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CDK5 Gene
Publications for CDK5 Gene
- Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. (PMID: 19343042) Choi HS … Kim YH (Journal of human genetics 2009) 3 22 44 58
- Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. (PMID: 17591690) Lee JH … Kim KT (Journal of cell science 2007) 3 4 22 58
- Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. (PMID: 18042622) Miyamoto Y … Tanoue A (Journal of cell science 2007) 3 4 22 58
- Mechanism of CDK5/p25 binding by CDK inhibitors. (PMID: 15689152) Mapelli M … Musacchio A (Journal of medicinal chemistry 2005) 3 4 22 58
- Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. (PMID: 12691662) Gong X … Mao Z (Neuron 2003) 3 4 22 58
Products for CDK5 Gene
- Browse R&D Systems for Antibodies
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- R&D Systems cDNA Clones for CDK5
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- Custom Antibody ServicesOriGene Antibodies for CDK5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK5
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK5
- Origene Custom Protein Services for CDK5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK5
- Browse OriGene Inhibitory RNA Products For CDK5
- OriGene qPCR primer pairs and template standards for CDK5
- OriGene qPCR primer pairs for CDK5
- OriGene CRISPR knockouts for CDK5
- OriGene ORF clones in human for CDK5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK5
- GenScript: Next-day shipping of latest version cDNA ORF clones for CDK5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CDK5
- GenScript Custom Assay Services for CDK5
- GenScript Custom overexpressing Cell Line Services for CDK5
- GenScript: Design CRISPR guide RNA sequences for CDK5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK5
- Cell Signaling Technology (CST) Antibodies for CDK5 (CDK5)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for CDK5 (CDK5)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CDK5
- Sino Biological Recombinant Proteins for CDK5
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CDK5
- Novus Biologicals lysates and proteins for CDK5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CDK5
- Abcam proteins for CDK5
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- ProSpec Recombinant Proteins for CDK5
- Cloud-Clone Corp. Antibodies for CDK5
- Cloud-Clone Corp. Proteins for CDK5
- Cloud-Clone Corp. Assay Kits for CDK5
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CDK5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CDK5
- Addgene plasmids for CDK5
- antibodies-online: Search results for 241 available CDK5 Antibodies ranked by validation data
- Compare Top CDK5 Antibodies
- Recommended
- 201 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 124 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 123 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 50 available CDK5 Elisa Kits ranked by validation data
- Compare Top CDK5 Elisa Kits
- antibodies-online: Search results for 19 available CDK5 Proteins ranked by validation data
- Compare Top CDK5 Proteins
- GeneTex CDK5 antibody for CDK5
- Search GeneTex for Proteins for CDK5
- ViGene Biosciences adenoviral particle packaged cDNA for CDK5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDK5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDK5 gene
- Search ViGene Biosciences for CDK5
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK5
- Search Santa Cruz Biotechnology (SCBT) for CDK5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK5
- Horizon Cell Lines for CDK5
- genomics-online: cdna clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
- orf clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
- genomics-online: gRNA clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
- genomics-online: primer clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
- genomics-online: shRNA clones - Search results for 131 available CDK5 gene related products
- Overview of 131 available CDK5 gene related products
Sources for CDK5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew