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CDK5 Gene

protein-coding GIFtS: 68

GC07M150381

cyclin-dependent kinase 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.22 ^³
PSSALRE ^¹, ²

Descriptions
Serine/threonine-protein kinase PSSALRE ^³
TPKII catalytic subunit ^³
Tau protein kinase II catalytic subunit ^³
cyclin-dependent kinase 5 ^², ³
protein kinase CDK5 splicing ^²

External Ids
HGNC: 1774¹
Entrez Gene: 1020²
UniProtKB: Q00535³
Ensembl: ENSG00000164885⁷

Search outside databases for aliases for CDK5 gene

Previous GC identifers: GC07M148997 GC07M150065 GC07M150142 GC07M150188

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535

Function: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1

cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which

activates the kinase

Gene Wiki entry for CDK5 (Cyclin-dependent_kinase_5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDK5 gene

Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36

CDK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M150381: (about GC identifiers)

Start:	150,381,832 bp from pter
End:	150,385,929 bp from pter
Size:	4,098 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 150,080,438-150,084,535

RefSeq DNA sequence:

NC_000007.12 NT_007914.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535 (See protein sequence)

Recommended Name: Cell division protein kinase 5

Size: 292 amino acids; 33304 Da

Subunit: Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular

complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK

Subcellular location: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity).

Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the

peripheral lamellipodia (By similarity)

PDB structures from and Proteopedia :

1H4L (3D)

1LFR (3D)

1UNG (3D)

1UNH (3D)

1UNL (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004926.1

ENSEMBL proteins:

ENSP00000297518

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CDK5
	Millipore Purified and/or Recombinant CDK5 Protein
	Sigma-Aldrich Proteins for CDK5
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDK5
	Recombinant Proteins from Abcam (p35 + p25, Cdk5, Cdks)
	Human Recombinant Proteins from Abnova (CDK5)

OriGene Purified Recombinant Human Protein: CDK5

5/11 Gene Ontology (GO) cellular component terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005829	cytosol	IEA	--
GO:0016020	membrane	ISS	--
GO:0030027	lamellipodium	IEA	--

About this table

Antibodies for CDK5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CDK5
	Sigma-Aldrich Antibodies for CDK5
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDK5
	Antibodies from Abcam (p35 + p25, Cdk5, Cdks), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDK5)
	Novus Biologicals Antibodies for CDK5

Assays for CDK5:

	Invitrogen Assays for CDK5
	Millipore Kits and Assays for the Analysis of CDK5
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q00535

ProtoNet protein and cluster: Q00535

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK5)
		Millipore RNAi Products for the Analysis of CDK5 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004935

Applied Biosystems Silencer® siRNAs for CDK5

Sigma-Aldrich siRNA and siRNA Panels for CDK5

Sigma-Aldrich shRNA Panels and shRNA for CDK5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDK5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004935
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004935
untagged cDNA clones in CMV expression vector (see all 2): NM_004935

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004935

UniProtKB/Swiss-Prot: CDK5_HUMAN, Q00535

Function: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1

cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which

activates the kinase

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.22

Genatlas biochemistry entry for CDK5:

cyclin dependent kinase 5,specifically expressed in postmitotic neurons and in muscle

cells,associating for activation with its regulatory subunit p35 (CDK5R1) to form one of the two

main tau-kinases,complexing with cyclin D (D1,D2,D3),involved in cell-cycle regulation of G1 to S

transition,phosphorylating DARRP2 dopamine and cAMP regulated and modulating dopamine

signaling,associating with p25,a truncated form of p35 with a resultant increase in CDK5 kinase

activity,hyperphosphorylation of tau which reduces tau's ability to associate microtubules

7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cdk5):

behavior/neurological	homeostasis/metabolism	lethality-prenatal/perinatal	nervous system	normal
respiratory system	touch/vibrissae

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0002039	p53 binding	IEA	--
GO:0004693	cyclin-dependent protein kinase activity	TAS	8090221
GO:0005176	ErbB-2 class receptor binding	ISS	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for CDK5 (Your Favorite Gene powered by Ingenuity) (see all 9 )

CDK5 Signaling
Reelin Signaling in Neurons
Neuregulin Signaling
Inositol Phosphate Metabolism
Huntington's Disease Signaling

GeneDecks CDK5 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDK5

5/98 Interacting proteins for CDK5 (ENSP00000297518³ Q00535^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 98 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN1B	P46527¹	STRING (score=.974) EBI-1041567, EBI-519280
MAPT	P10636²	STRING (score=.999) MINT-3974182
CDKN1A	P38936¹	EBI-1041567, EBI-375077
AATK	Q6ZMQ8-1¹	EBI-1041567, EBI-2008436
CDK5R1	ENSP00000318486³	STRING (score=.999)

About this table

5/39 Gene Ontology (GO) biological process terms (links to tree view) (see all 39 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0001963	synaptic transmission, dopaminergic	IEA	--
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0006886	intracellular protein transport	IEA	--
GO:0007160	cell-matrix adhesion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CDK5

Sigma-Aldrich Small Molecules for CDK5:

Inhibitor

Compounds for CDK5 available from Tocris Bioscience

Compound	Action	CAS number
Apigenin	Protein kinase inhibitor	[520-36-5]
Kenpaullone	Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3	[142273-20-9]

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10/25 Novoseek chemical compound relationships for CDK5 gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
purvalanol	69.81	1	16611631 (1)
kenpaullone	67.18	1	15950951 (1)
glycogen	66.77	60	8627328 (2), 11805297 (2), 16818492 (2), 7566342 (1) (see all 37)
threonine	62.76	40	17697781 (1), 17341134 (1), 18184784 (1), 8306873 (1) (see all 22)
okadaic acid	22.84	2	9599018 (1)
lithium	19.34	3	15979805 (2), 10629766 (1)
pd 98,059	18.90	3	15695523 (1), 15485494 (1)
amino acid	18.31	1	12230554 (1)
colchicine	10.16	5	12941380 (2), 15979805 (1), 15950951 (1)
gtp	9.80	15	12596920 (2), 15492003 (2), 10884379 (1), 18948252 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK5)
		Millipore RNAi Products for the Analysis of CDK5 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004935

Sigma-Aldrich siRNA and siRNA Panels for CDK5

Sigma-Aldrich shRNA Panels and shRNA for CDK5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004935

REFSEQ mRNAs for CDK5 gene:

NM_004935.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004935

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004935
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004935
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004935

Additional cDNA sequence:

AK026533.1 AY049778.1 AY927560.1 BC005115.1 BT006680.1 CR457041.1 DQ411039.1 L04658.1

X66364.1

11 DOTS entries:

DT.319808 DT.97839636 DT.121074391 DT.100022516 DT.121074369 DT.121074491 DT.95132417 DT.95372485

DT.95372486 DT.121074488 DT.92466216

24/122 AceView cDNA sequences (see all 122 ):

N52899 CF128142 CA431641 BX489021 BX112764 AV709223 BU529114 BT006680

BM727541 CA429180 AA952919 BC005115 AK026533 CB144453 AI086997 BF434699

AI306490 AA482510 BV177642 AY049778 BE673479 AA306623 NM_004935 X66364

highest scoring ESTs for CDK5:

L04658 X66364 AA159400 AA306623 AI279489 AI360563 AI557251 AI589890 AK026533 AU099986

Unigene Cluster for CDK5:

Cyclin-dependent kinase 5

Hs.647078 [show with all ESTs]

Unigene Representative Sequence: BG577212

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK5 (see all 7 )

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13a	·	13b
SP1:			-														-						-
SP2:																	-						-
SP3:			-				-										-						-
SP4:																	-		-
SP5:			-														-		-				-

About this scheme

ECgene alternative splicing isoforms for CDK5

1 Ensembl transcript including schematic representation:

ENST00000297518

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDK5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDK5

¹ / ² / ³

4 probe-sets matching CDK5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40549_at²^{, 3}	U95-A	2	1.00	0.88	0.96	0.97	L04658	1.00	1.00	1.00	1
1206_at²^{, 3}	U95-A	2	1.00	0.88	0.94	1.04	X66364	1.00	1.00	1.00	1
204247_s_at²^{, 3}	U133-A	2	1.00	0.86	--	--	NM_004935	0.60	1.00	0.82	1
204247_s_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--

GeneDecks CDK5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGTCAGCCG

SOURCE GeneReport for Unigene cluster: Hs.647078

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDK5 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDK5¹	--	cyclin-dependent kinase 5	91.76(n) 99.65(a)	475537 XM_532760.2 XP_532760.2
chimpanzee (Pan troglodytes)	CDK5¹	--	cyclin-dependent kinase 5	99.66(n) 100(a)	463891 XM_519523.2 XP_519523.2
cow (Bos taurus)	CDK5¹	--	cyclin-dependent kinase 5	92.35(n) 99.66(a)	281066 NM_174017.2 NP_776442.1
rat (Rattus norvegicus)	Cdk5¹	--	cyclin-dependent kinase 5	90.07(n) 99.32(a)	140908 NM_080885.1 NP_543161.1
mouse (Mus musculus)	Cdk5^{1, 5}	5 (12.00 cM)⁵	cyclin-dependent kinase 5^{1, 5}	90.87(n)¹ 99.66(a)¹	12568¹ NM_007668.3¹ NP_031694.1¹ AI550418⁵ AK051790⁵ (see all 18)

About this table Species with no ortholog for CDK5

ENSEMBL Gene Tree for CDK5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDK5 gene

PFTK2² PFTK1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/35 NCBI SNPs in CDK5 are shown (see all 35 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs9278^1,2	C,F	150381913(-)	`CAGCCG/AGGGTG`	1	--	ut3¹ ese³		8		NA MN CSAM EA	850
--	rs2069460^1,2	C,F	150382024(-)	`GGCCCC/TGGGAC`	1	--	ut3¹ ese³		6		NA MN CSAM EA	524
	rs35051446^1,2	F	150381943(-)	`TGGTGC/TGCTGT`	1	--	ut3¹		5		MN CSAM EA	404
--	rs12537523^1,2	C	150381499(+)	`TGAGGA/GAAAGG`	1	--	ng5¹		0	--	--	--	--
--	rs2069461^1,2	C	150381914(-)	`CCAGCC/TGGGGT`	1	--	ut3¹ ese³		6		NA MN CSAM EA	452
--	rs1057766^1,2	C	150383585(-)	`CGAGCC/TTTTGG`	1	A/A	syn¹		5		MN CSAM EA	400
	rs2069456^1,2	A,C,F,H	150383541(-)	`CTAGAA/CGATGG`	1	--	int¹		14		NA EU EA WA MN CSAM	1406
	rs1549759^1,2	A,C,F,H	150384397(+)	`TCAGAG/ATGACA`	1	--	int¹		5		NA EU EA WA	586
	rs2069459^1,2	C,F,H	150382523(-)	`CAGCTG/TTGGCC`	1	--	int¹ spl³		6		NA EU EA WA	1994
	rs2069446^1,2	A,C,F	150385442(-)	`ACCCTT/CCCGGA`	1	--	int¹		1		NA	162

About this table

HapMap Linkage Disequilibrium images for CDK5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123831

10/35 Novoseek disease relationships for CDK5 gene (see all 35 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurofibrillary tangles	77.94	8	8870824 (2), 9666145 (1), 12719630 (1), 11231011 (1) (see all 7)
tauopathies	75.94	3	17113760 (2), 17908241 (1)
alzheimers disease	74.68	58	9666145 (2), 18350355 (2), 12230554 (2), 15917097 (2) (see all 38)
paired helical filament	74.65	8	9666145 (1), 15975083 (1), 8870824 (1), 11065131 (1) (see all 5)
neurodegeneration	71.43	39	16932754 (4), 15009631 (2), 14673208 (2), 17932412 (2) (see all 25)
neurodegenerative diseases	70.49	59	17979810 (4), 16600851 (2), 17003520 (2), 15135890 (2) (see all 31)
amyotrophic lateral sclerosis	57.00	22	14673208 (2), 9596352 (2), 11464850 (2), 10509378 (1) (see all 14)
brain diseases	45.38	3	17241267 (1), 15917097 (1)
senile plaques	44.10	2	12719630 (1), 14681576 (1)
retinoblastoma	37.40	2	18351461 (2)

About this table

Human Genome Epidemiology Navigator: CDK5 (26 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/469 PubMed articles for CDK5 gene (see all 469 ):

A family of human cdc2-related protein kinases. (PubMed id 1639063)^{2, 3, 4} Meyerson M....Tsai L.H. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PubMed id 14521924)^{3, 4} Honma N....Hisanaga S. (2003)
Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PubMed id 8275715)^{2, 3} Demetrick D.J....Beach D.H. (1994)
Cdk5 regulates the organization of Nestin and its association with p35. (PubMed id 12832492)^{1, 3} Sahlgren C.M....Eriksson J.E. (2003)
Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. (PubMed id 17145757)^{1, 3} Lin H....Lin S.Y. (2007)
Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. (PubMed id 10500146)^{1, 3} Sharma P....Pant H.C. (1999)
Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease. (PubMed id 18480410)^{1, 3} Sun K.H....Shah K. (2008)
Identification of nuclear import mechanisms for the neuronal Cdk5 activator. (PubMed id 17060323)^{1, 3} Fu X....Qi R.Z. (2006)
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. (PubMed id 10896159)^{1, 3} Zukerberg L.R....Tsai L.H. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1020	HGNC: 1774	AceView: CDK5	Ensembl:ENSG00000164885	euGenes: HUgn1020
ECgene: CDK5	H-InvDB: CDK5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDK5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CDK5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDK5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDK5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDK5		Antibodies for CDK5
	Explore super-pooled esiRNAs		Proteins for CDK5
	Lentivirus-delivered shRNAs for CDK5		Small molecules for CDK5
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDK5)
	Antibodies (CDK5)
	Chimera RNAi (CDK5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDK5

	Recombinant Proteins (p35 + p25, Cdk5, Cdks)
	Antibodies (p35 + p25, Cdk5, Cdks)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for CDK5

	Drugs/Proteins for CDK5
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDK5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDK5 Gene at Home site.
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CDK5 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CDK5

Summaries
for CDK5

Genomic Location
for CDK5

Proteins
for CDK5

Protein Domains/
Families
for CDK5

Gene Function
for CDK5

Pathways & Interactions
for CDK5

Drugs & Compounds
for CDK5

Transcripts
for CDK5

Expression
for CDK5

Orthologs
for CDK5

Paralogs
for CDK5

SNPs/Variants
for CDK5

Disorders & Mutations
for CDK5

Medical News
for CDK5

Publications
for CDK5

Search for CDK5

Genome Databases showing CDK5

Other Databases showing CDK5

Specialized Databases showing CDK5

Licensable Technologies
for CDK5

Services
for CDK5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDK5 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CDK5

Summariesfor CDK5

Genomic Locationfor CDK5

Proteinsfor CDK5

Protein Domains/Familiesfor CDK5

Gene Functionfor CDK5

Pathways & Interactionsfor CDK5

Drugs & Compoundsfor CDK5

Transcriptsfor CDK5

Expression for CDK5

Orthologsfor CDK5

Paralogsfor CDK5

SNPs/Variantsfor CDK5

Disorders & Mutationsfor CDK5

Medical Newsfor CDK5

Publicationsfor CDK5

Search for CDK5

Genome Databases showing CDK5

Other Databases showing CDK5

Specialized Databases showing CDK5

Licensable Technologiesfor CDK5

Servicesfor CDK5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDK5

Summaries
for CDK5

Genomic Location
for CDK5

Proteins
for CDK5

Protein Domains/
Families
for CDK5

Gene Function
for CDK5

Pathways & Interactions
for CDK5

Drugs & Compounds
for CDK5

Transcripts
for CDK5

Expression
for CDK5

Orthologs
for CDK5

Paralogs
for CDK5

SNPs/Variants
for CDK5

Disorders & Mutations
for CDK5

Medical News
for CDK5

Publications
for CDK5

Licensable Technologies
for CDK5

Services
for CDK5