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Aliases for CDK4 Gene

Aliases for CDK4 Gene

  • Cyclin-Dependent Kinase 4 2 3
  • Cell Division Protein Kinase 4 3 4
  • EC 2.7.11.22 4 63
  • PSK-J3 3 4
  • EC 2.7.11 63
  • CMM3 3

External Ids for CDK4 Gene

Previous GeneCards Identifiers for CDK4 Gene

  • GC12M058284
  • GC12M057858
  • GC12M056428
  • GC12M058142
  • GC12M055178

Summaries for CDK4 Gene

Entrez Gene Summary for CDK4 Gene

  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK4 Gene

CDK4 (Cyclin-Dependent Kinase 4) is a Protein Coding gene. Diseases associated with CDK4 include cdk4-related cutaneous malignant melanoma and melanoma, cutaneous malignant, 3. Among its related pathways are PI3K-Akt signaling pathway and Developmental Biology. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK1.

UniProtKB/Swiss-Prot for CDK4 Gene

  • Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Tocris Summary for CDK4 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK4 Gene

Genomics for CDK4 Gene

Regulatory Elements for CDK4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK4 Gene

Chromosome:
12
Start:
57,747,727 bp from pter
End:
57,756,013 bp from pter
Size:
8,287 bases
Orientation:
Minus strand

Genomic View for CDK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK4 Gene

Proteins for CDK4 Gene

  • Protein details for CDK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11802-CDK4_HUMAN
    Recommended name:
    Cyclin-dependent kinase 4
    Protein Accession:
    P11802
    Secondary Accessions:
    • B2R9A0
    • B4DNF9
    • O00576
    • Q6FG61

    Protein attributes for CDK4 Gene

    Size:
    303 amino acids
    Molecular mass:
    33730 Da
    Quaternary structure:
    • Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on Tyr-88 and Tyr-89); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Interacts with CEBPA (when phosphorylated) (PubMed:15107404).

    Three dimensional structures from OCA and Proteopedia for CDK4 Gene

    Alternative splice isoforms for CDK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK4 Gene

Proteomics data for CDK4 Gene at MOPED

Post-translational modifications for CDK4 Gene

  • Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
  • Ubiquitination at Lys 22, Lys 35, Lys 106, Lys 155, Lys 211, Lys 282, and Lys 297
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK4 (CDK4)

Domains & Families for CDK4 Gene

Gene Families for CDK4 Gene

Graphical View of Domain Structure for InterPro Entry

P11802

UniProtKB/Swiss-Prot:

CDK4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK4: view

Function for CDK4 Gene

Molecular function for CDK4 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 4 involved in cell cycle regulation (G1 to S transition),complexing with cyclin D (D1,D2,D3),amplified in malignant glioblastoma and anaplastic astrocytoma,and in diffuse large B cell lymphoma ; amplified in osteosarcoma with OS9,SAS and PRIM1and in sporadic breast carcinomas,predisposing to familial melanoma by inducing abnormal repair of ultraviolet radiation. Loss of CDK4 expression causes insulin deficient diabetes,and CDK4 activation results in B islet cell hyperplasia in mice
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequennt activation.
UniProtKB/Swiss-Prot Function:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Enzyme Numbers (IUBMB) for CDK4 Gene

Gene Ontology (GO) - Molecular Function for CDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA 8114739
GO:0005515 protein binding IPI 7568034
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK4: view
genes like me logo Genes that share phenotypes with CDK4: view

Animal Models for CDK4 Gene

MGI Knock Outs for CDK4:

Animal Model Products

miRNA for CDK4 Gene

miRTarBase miRNAs that target CDK4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CDK4 Gene

Localization for CDK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK4 Gene

Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK4 Gene COMPARTMENTS Subcellular localization image for CDK4 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
extracellular 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 17420273
GO:0000785 chromatin IDA 18827403
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with CDK4: view

Pathways & Interactions for CDK4 Gene

genes like me logo Genes that share pathways with CDK4: view

PCR Array Products

SIGNOR curated interactions for CDK4 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 7603984
GO:0000278 mitotic cell cycle TAS --
GO:0002088 lens development in camera-type eye IEA --
GO:0006325 chromatin organization TAS --
GO:0006468 protein phosphorylation IDA 8114739
genes like me logo Genes that share ontologies with CDK4: view

Drugs & Compounds for CDK4 Gene

(107) Drugs for CDK4 Gene - From: NovoSeek, ClinicalTrials, HMDB, DGIdb, PharmGKB, DrugBank, ApexBio, Tocris, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palbociclib Approved Pharma Inhibition, Target, Inhibitor 0
Estradiol Approved, Investigational Pharma Sex hormone 1057
Somatropin recombinant Approved, Investigational Pharma 0
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Aromatase Inhibitors, Hormone therapy, Potent aromatase (CYP19) inhibitor 252
Fulvestrant Approved, Investigational Pharma Antagonist Estrogen receptor antagonist,high affinity, Hormone therapy 157

(52) Additional Compounds for CDK4 Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
(R)-CR8
294646-77-8
Arcyriaflavin A
118458-54-1
NSC 663284
383907-43-5
SU 9516
377090-84-1
genes like me logo Genes that share compounds with CDK4: view

Drug Products

Transcripts for CDK4 Gene

Unigene Clusters for CDK4 Gene

Cyclin-dependent kinase 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7:
SP8: - -
SP9:

Relevant External Links for CDK4 Gene

GeneLoc Exon Structure for
CDK4
ECgene alternative splicing isoforms for
CDK4

Expression for CDK4 Gene

mRNA expression in normal human tissues for CDK4 Gene

Protein differential expression in normal tissues from HIPED for CDK4 Gene

This gene is overexpressed in Uterus (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK4 Gene



SOURCE GeneReport for Unigene cluster for CDK4 Gene Hs.95577

genes like me logo Genes that share expression patterns with CDK4: view

Protein tissue co-expression partners for CDK4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK4 Gene

Orthologs for CDK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK4 35
  • 92.52 (n)
  • 97.03 (a)
-- 36
  • 73 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
CDK4 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDK4 35
  • 90.76 (n)
  • 97.03 (a)
CDK4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk4 35
  • 88.12 (n)
  • 94.72 (a)
Cdk4 16
Cdk4 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK4 35
  • 99.89 (n)
  • 100 (a)
CDK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk4 35
  • 87.9 (n)
  • 95.05 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CDK4 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk4 35
  • 71.71 (n)
  • 79.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52574 35
zebrafish
(Danio rerio)
Actinopterygii cdk4 35
  • 68.28 (n)
  • 74.14 (a)
Dr.14474 35
cdk4 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdk4 37
  • 47 (a)
Cdk4 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-4 37
  • 42 (a)
cdk-4 36
  • 30 (a)
ManyToMany
F52B5.2 36
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 36
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3270 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for CDK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK4 Gene

ENSEMBL:
Gene Tree for CDK4 (if available)
TreeFam:
Gene Tree for CDK4 (if available)

Paralogs for CDK4 Gene

Paralogs for CDK4 Gene

Pseudogenes.org Pseudogenes for CDK4 Gene

genes like me logo Genes that share paralogs with CDK4: view

Variants for CDK4 Gene

Sequence variations from dbSNP and Humsavar for CDK4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2069501 -- 57,750,998(-) GTGAC(A/G)AGTGG reference, synonymous-codon
rs2069502 -- 57,750,882(-) TGGGA(A/G)TAGGA intron-variant
rs2270777 -- 57,751,373(-) AAAGG(A/C/G)GATTG intron-variant
rs2640603 -- 57,751,070(+) CCTCT(A/T)AGAAA reference, synonymous-codon
rs3211612 - 57,751,316(-) ATCCC(A/G)AACTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CDK4 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv899123 CNV Loss 21882294
nsv826384 CNV Gain 20364138
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195
nsv826386 CNV Gain 20364138

Variation tolerance for CDK4 Gene

Residual Variation Intolerance Score: 22.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK4 Gene

HapMap Linkage Disequilibrium report
CDK4
Human Gene Mutation Database (HGMD)
CDK4

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK4 Gene

Disorders for CDK4 Gene

MalaCards: The human disease database

(71) MalaCards diseases for CDK4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
cdk4-related cutaneous malignant melanoma
  • melanoma, cutaneous malignant, 3
melanoma, cutaneous malignant, 3
  • cmm3
dedifferentiated liposarcoma
  • ddls
malignant melanoma, somatic
  • familial melanoma
ring chromosome 7
  • chromosome 7 ring
- elite association
Search CDK4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK4_HUMAN
  • Melanoma, cutaneous malignant 3 (CMM3) [MIM:609048]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:7652577, ECO:0000269 PubMed:8528263, ECO:0000269 PubMed:9311594, ECO:0000269 PubMed:9425228}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CDK4

Genetic Association Database (GAD)
CDK4
Human Genome Epidemiology (HuGE) Navigator
CDK4
Tumor Gene Database (TGDB):
CDK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK4
genes like me logo Genes that share disorders with CDK4: view

No data available for Genatlas for CDK4 Gene

Publications for CDK4 Gene

  1. Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4. (PMID: 19917880) Barhoover M.A. … Thomas R.S. (Mol. Pharmacol. 2010) 23 67
  2. Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. (PMID: 20028382) Bai Y. … Xie L.P. (Cancer Sci. 2010) 23 67
  3. Molecular-docking-guided 3D-QSAR studies of substituted isoquinoline-1,3-(2H,4H)-diones as cyclin-dependent kinase 4 (CDK4) inhibitors. (PMID: 19543928) Lu X.Y. … You Q.D. (J Mol Model 2010) 23 67
  4. Inhibition of peptidyl-prolyl cis/trans isomerase Pin1 induces cell cycle arrest and apoptosis in vascular smooth muscle cells. (PMID: 19904610) Lv L. … Zhang J. (Apoptosis 2010) 23 67
  5. Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators. (PMID: 19908243) Mateen S. … Agarwal R. (Mol. Carcinog. 2010) 23 67

Products for CDK4 Gene

  • Addgene plasmids for CDK4

Sources for CDK4 Gene

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