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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK4 Gene

protein-coding   GIFtS: 78
GCID: GC12M058142

Cyclin-Dependent Kinase 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 41 2
Cell Division Protein Kinase 42 3
PSK-J32 3
EC 2.7.11.223 8
CMM32 5
EC 2.7.118

External Ids:    HGNC: 17731   Entrez Gene: 10192   Ensembl: ENSG000001354467   OMIM: 1238295   UniProtKB: P118023   

Export aliases for CDK4 gene to outside databases

Previous GC identifers: GC12M057743 GC12M058284 GC12M057858 GC12M056428 GC12M055178


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK4 Gene:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar
to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase
complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the
G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This
kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this
gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be
associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK4 Gene: 
CDK4 (cyclin-dependent kinase 4) is a protein-coding gene. Diseases associated with CDK4 include melanoma, and dedifferentiated liposarcoma, and among its related super-pathways are Glioma and Cyclins and Cell Cycle Regulation. GO annotations related to this gene include cyclin binding and protein complex binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802
Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the
retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the
subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its
transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear
translocation and activity of the cyclin D-CDK4 complex

summary for CDK4 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK4 (Cyclin-dependent kinase 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK4 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13

CDK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058142:  view genomic region     (about GC identifiers)

Start:
58,141,510 bp from pter      End:
58,149,796 bp from pter
Size:
8,287 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 4  
Size: 303 amino acids; 33730 Da
Subunit: Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3).
Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary
complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B
(phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172
phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either
inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B
prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2.
Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the
interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin
D-dependent enzyme activity of CDK4
Subcellular location: Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4
complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane
and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps.
Colocalizes with RB1 after release into the nucleus
6 PDB 3D structures from and Proteopedia for CDK4:
1LD2 (3D)        2W96 (3D)        2W99 (3D)        2W9F (3D)        2W9Z (3D)        3G33 (3D)    
Secondary accessions: O00576 Q6FG61

Explore the universe of human proteins at neXtProt for CDK4: NX_P11802

Explore proteomics data for CDK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by
    CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B
    complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation
    state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the
    T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of
    CDKN1B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11802

  • 4/17 DME Specific Peptides for CDK4 (P11802) (see all 17)
     ENILVTS  HPNVVRL  LADFGLA  ETIKDLM 

    CDK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK4 Protein Expression
    REFSEQ proteins: NP_000066.1  
    ENSEMBL proteins: 
     ENSP00000257904   ENSP00000447005   ENSP00000448885   ENSP00000447779   ENSP00000447274  
     ENSP00000448098   ENSP00000449391   ENSP00000449179   ENSP00000448963   ENSP00000446763  
     ENSP00000449725   ENSP00000439076   ENSP00000316889  
    Reactome Protein details: P11802
    Human Recombinant Protein Products for CDK4: 
    EMD Millipore Purified and/or Recombinant CDK4 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDK4
    OriGene Protein Over-expression Lysate for CDK4
    OriGene MassSpec for CDK4 
    OriGene Custom Protein Services for CDK4
    GenScript Custom Purified and Recombinant Proteins Services for CDK4
    Novus Biologicals CDK4 Proteins
    Novus Biologicals CDK4 Lysates
    Sino Biological Recombinant Protein for CDK4
    Sino Biological Cell Lysate for CDK4 
    ProSpec Recombinant Protein for CDK4
    Cloud-Clone Corp. Proteins for CDK4 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0000785chromatin IDA18827403
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    CDK4 for ontologies           About GeneDecksing



    CDK4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK4
    R&D Systems Antibodies for CDK4
    Cell Signaling Technology (CST) Antibodies for CDK4 
    OriGene Antibodies for CDK4
    OriGene Custom Antibody Services for CDK4
    GenScript Custom Superior Antibodies Services for CDK4
    Novus Biologicals CDK4 Antibodies
    Abcam antibodies for CDK4
    Cloud-Clone Corp. Antibodies for CDK4 
    ThermoFisher Antibody for CDK4
    LSBio Antibodies in human, mouse, rat for CDK4 

    Assay Products for CDK4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK4 
    Cloud-Clone Corp. CLIAs for CDK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 4 
    CDK4 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P11802

    ProtoNet protein and cluster: P11802

    UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK4_HUMAN, P11802
    Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the
    retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the
    subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
    Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
    and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its
    transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear
    translocation and activity of the cyclin D-CDK4 complex
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic
    activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of
    the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by
    INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at
    Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows
    phosphorylation of Thr-172 of CDK4 and subsequennt activation

         Genatlas biochemistry entry for CDK4:
    cyclin dependent kinase 4 involved in cell cycle regulation (G1 to S transition),complexing with cyclin D
    (D1,D2,D3),amplified in malignant glioblastoma and anaplastic astrocytoma,and in diffuse large B cell lymphoma ;
    amplified in osteosarcoma with OS9,SAS and PRIM1and in sporadic breast carcinomas,predisposing to familial
    melanoma by inducing abnormal repair of ultraviolet radiation. Loss of CDK4 expression causes insulin deficient
    diabetes,and CDK4 activation results in B islet cell hyperplasia in mice

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IDA8114739
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11896535
         
    CDK4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK4:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Upregulation of Wnt/beta-caten 

         15/19 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdk4) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    CDK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDK4: Cdk4tm2.1Bbd Cdk4tm1Kiyo Cdk4tm1Bbd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK4:
    hsa-mir-34b (MIRT000764), hsa-mir-302a (MIRT003636), hsa-mir-24 (MIRT000117), hsa-mir-145 (MIRT005879), hsa-mir-124 (MIRT002625), hsa-mir-34a (MIRT000763), hsa-mir-34c-5p (MIRT000765), hsa-mir-34b (MIRT003450)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK4 (see all 12):
    hsa-miR-3163 hsa-miR-3910 hsa-miR-198 hsa-miR-545 hsa-miR-373* hsa-miR-486-5p hsa-miR-124 hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidCDK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of CDK4 Gene knock-down
    OriGene RNAi products in human, mouse, rat for CDK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK4
    Sirion Biotech Customized adenovirus for overexpression of CDK4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK4 (see all 11)
    OriGene ORF clones in mouse, rat for CDK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK4 (NM_000075)
    Sino Biological Human cDNA Clone for CDK4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK4
    Sirion Biotech Customized lentivirus for stable overexpression of CDK4 
                         Customized lentivirus expression plasmids for stable overexpression of CDK4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK4
    Search LifeMap BioReagents cell lines for CDK4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK4 About   (see all 51)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Signaling Pathways in Glioblastoma0.36
    Non-small cell lung cancer0.51
    Bladder cancer0.31
    Melanoma0.43
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    Cell Cycle Control by BTG Proteins0.36
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    5p53 Pathway
    p53 Signaling0.38
    p53 Pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 EMD Millipore Pathways for CDK4 (see all 13)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)

    1 R&D Systems Pathway for CDK4
        Akt Signaling Pathway

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK4 (see all 12)
        Cell Cycle Control by BTG Proteins
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    Glioblastoma Multiforme
    G1-S Phase Transition

    1 Cell Signaling Technology (CST) Pathway for CDK4
        Cell Cycle / Checkpoint Control

    5/7 GeneGo (Thomson Reuters) Pathways for CDK4 (see all 7)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Cell cycle (generic schema)

    5/19 BioSystems Pathways for CDK4 (see all 19)
        DNA damage response
    Cell cycle
    G1 to S cell cycle control
    Integrated Breast Cancer Pathway
    Spinal Cord Injury

    1 Sino Biological Pathway for CDK4 
        p53 Pathway

    5/10        Reactome Pathways for CDK4 (see all 10)
        G1 Phase
    Mitotic G1-G1/S phases
    Ubiquitin-dependent degradation of Cyclin D1
    Cell Cycle
    Meiotic Recombination


    5/17         Kegg Pathways  (Kegg details for CDK4) (see all 17):
        Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Tight junction
    T cell receptor signaling pathway


    CDK4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/255 Interacting proteins for CDK4 (P118021, 2, 3 ENSP000002579044) via UniProtKB, MINT, STRING, and/or I2D (see all 255)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF655Q8N7201, 2, 3, ENSP000003938764EBI-295644,EBI-625509 MINT-50595 MINT-50594 I2D: score=3 STRING: ENSP00000393876
    CDKN1BP465271, 2, 3, ENSP000002288724EBI-295644,EBI-519280 MINT-3379718 I2D: score=8 STRING: ENSP00000228872
    CCND3P302811, 2, 3, ENSP000003620824EBI-295644,EBI-375013 MINT-50438 I2D: score=10 STRING: ENSP00000362082
    DDAH2O958652, 3MINT-8251359 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8251359 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP7603984
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation IDA8114739
    GO:0007165signal transduction IEA--
    GO:0007623circadian rhythm IEA--

    CDK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK4 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK4:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CDK4

    Compounds for CDK4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for CDK4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    Purvalanol-- --target--11752352

    10/118 Novoseek inferred chemical compound relationships for CDK4 gene (see all 118)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fascaplysin 85 13 10973815 (4), 16816972 (2), 16936279 (1), 16904725 (1) (see all 7)
    nu6102 67 2 15928920 (2)
    flavopiridol 65.7 12 8674031 (4), 10493518 (2), 16127615 (1), 10375610 (1) (see all 7)
    ag-126 62.1 4 19080374 (1), 17374178 (1), 18703151 (1), 16125882 (1)
    17-(allylamino)-17-demethoxygeldanamycin 61.7 4 18281495 (1), 18245548 (1), 18193424 (1), 17157164 (1)
    geldanamycin 60.4 4 14633716 (1), 9390191 (1), 17643429 (1)
    dl 111it 53.2 4 16133535 (1), 16281086 (1)
    silymarin 51.9 10 16322307 (2), 9581834 (1), 12429923 (1), 19150384 (1) (see all 8)
    indole-3-carbinol 51 1 14635088 (1)
    olomoucine 50.6 2 17081516 (1), 9828096 (1)

    1 PharmGKB related drug/compound annotation for CDK4 gene    About this table
    Drug/compound PharmGKB Annotation
    somatropin recombinantCA  

    Search CenterWatch for drugs/clinical trials and news about CDK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK4 gene (2 alternative transcripts): 
    NM_000075.3  NM_052984.1  

    Unigene Cluster for CDK4:

    Cyclin-dependent kinase 4
    Hs.95577  [show with all ESTs]
    Unigene Representative Sequence: NM_000075
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257904(uc001spv.3 uc010ssb.2 uc001spw.3) ENST00000552713
    ENST00000549606 ENST00000553237 ENST00000546489 ENST00000551888 ENST00000547281
    ENST00000550419 ENST00000551800 ENST00000552254 ENST00000551706 ENST00000552388
    ENST00000552862 ENST00000547853 ENST00000540325 ENST00000312990
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-3163 hsa-miR-3910 hsa-miR-198 hsa-miR-545 hsa-miR-373* hsa-miR-486-5p hsa-miR-124 hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidCDK4 3' UTR sequence
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    Additional mRNA sequence: 

    AK297901.1 AK310724.1 AK313701.1 BC003644.2 BC005864.2 BC010153.2 BC015669.2 CR407668.1 
    CR542247.1 M14505.1 U79269.1 Z48970.1 

    24/27 DOTS entries (see all 27):

    DT.219465  DT.100851448  DT.92408932  DT.40113477  DT.445603  DT.100851457  DT.95222712  DT.97856917 
    DT.100851439  DT.121198842  DT.121642996  DT.95284131  DT.97789050  DT.121198761  DT.121198896  DT.91928527 
    DT.95339116  DT.100701889  DT.100716609  DT.121198886  DT.91772477  DT.91921800  DT.95339064  DT.95339068 

    24/974 AceView cDNA sequences (see all 974):

    BE549560 AA346442 BI467188 AA404721 CB265397 BE408706 AA305954 BG577285 
    BU151684 CR622282 CA313036 BE463902 BE296487 BM913299 AI311542 BU146932 
    AI718975 AI983391 CB143270 AI420551 BE905374 BQ061198 BQ071294 CR608247 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CDK4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                                -                                               -     -                                 
    SP2:                                -                                         -           -                                 
    SP3:                                -     -     -                                   -     -                                 
    SP4:                                -     -     -     -                             -     -                                 
    SP5:                                -     -                                                                                 


    ECgene alternative splicing isoforms for CDK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK4 expression in normal human tissues (normalized intensities)      CDK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAAGAA
    CDK4 Expression
    About this image


    CDK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Olfactory Bulb   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/ear/inner ear   

    See CDK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK4

    SOURCE GeneReport for Unigene cluster: Hs.95577
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK4 (see all 10): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Tight Junctions in human mouse rat
              Adipogenesis in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK4 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk41 , 5 cyclin-dependent kinase 41, 5 88.12(n)1
    94.72(a)1
      10 (74.50 cM)5
    125671  NM_009870.31  NP_034000.11 
     1270635345 
    lizard
    (Anolis carolinensis)
    Reptilia CDK46
    Uncharacterized protein
    76(a)
    1 ↔ 1
    2(66672480-66703503)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525742 hypothetical protein MGC52574 73.65(n)    BC051599.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144742 Transcribed sequence with weak similarity to protein more 75.76(n)    BI673022.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk43 cell proliferation protein
    serine/threonine kinase
    47(a)   2 53C9   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-43 serine/threonine kinase (CDC2/CDKX
    subfamily)
    42(a)   X(13551275-13552978)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    42(a)
    1 → many
    II(560078-560974)


    ENSEMBL Gene Tree for CDK4 (if available)
    TreeFam Gene Tree for CDK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK4 gene
    CDK182  CDK62  CDK52  CDK152  CDK12  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/219 SIMAP similar genes for CDK4 using alignment to 13 protein entries:     CDK4_HUMAN (see all proteins) (see all similar genes):
    CDK6    CDK3    CAMK2G    CDC2    CDK1    CDK7
    CAMK2A    STK17A    CDC2L1    CDK11B    CDC2L2    SPEG
    CDK11A    CDK5    CAMK2B    DKFZp686L20222    SRPK2    CDK15

    CDK4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK4
    PGOHUM00000244827


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 SNPs in CDK4 are shown (see all 206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0062014
    Melanoma, cutaneous malignant 3 (CMM3)4--see VAR_0062012 R H mis40--------
    VAR_0211524
    Melanoma, cutaneous malignant 3 (CMM3)4--see VAR_0211522 N S mis40--------
    rs115473281,2,4
    C,HMelanoma, cutaneous malignant 3 (CMM3)4 other191950881(-) AGGCCC/TGTGAT 2 R C mis1 ese36Minor allele frequency- T:0.00NS EA NA 410
    rs1048943401,2
    Cother191950882(-) GGCCCA/GTGATC 2 H R mis10--------
    rs1903357251,2
    --55178038(+) TCCTCC/TAAAAT 1 -- ds50010--------
    rs1819183441,2
    --55178259(+) TAAATC/TAGGGA 1 -- ds50010--------
    rs32116381,2
    C,F,A,H--55178261(-) TATCCC/GTGATT 1 -- ds500113Minor allele frequency- G:0.07NS NA WA 784
    rs25186891,2
    C,H--55178307(+) TAATAA/GGCAGG 1 -- ds50014Minor allele frequency- G:0.00NS EA 404
    rs32116371,2
    C,F,H--55178328(-) GCTAAA/TCTTTC 1 -- ds50013Minor allele frequency- T:0.02NS WA 404
    rs1870632671,2
    --55178347(+) AAGTAA/GAAGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CDK4 (58141510 - 58149796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899121CNV Loss21882294
    nsv510601CNV Loss20534489
    nsv899123CNV Loss21882294
    nsv470296CNV Loss18288195
    nsv470297CNV Gain18288195
    nsv826384CNV Gain20364138
    nsv826386CNV Gain20364138


    Human Gene Mutation Database (HGMD): CDK4
    SABiosciences Cancer Mutation PCR Assays
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing CDK4:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing CDK4
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123829   
    OMIM disorders: 609048  
    UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802
  • Melanoma, cutaneous malignant 3 (CMM3) [MIM:609048]: A malignant neoplasm of melanocytes, arising de novo
    or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 20/150 diseases for CDK4 (see all 150):    About MalaCards
    melanoma    dedifferentiated liposarcoma    atypical lipomatous tumor    atypical mole syndrome
    retroperitoneal sarcoma    spindle cell liposarcoma    cdk4-related cutaneous malignant melanoma    malignant melanoma, somatic
    juxtacortical osteosarcoma    familial melanoma    cutaneous malignant melanoma    mixed-type liposarcoma
    undifferentiated embryonal sarcoma of the liver    superficial spreading melanoma    female breast carcinoma    spindle cell lipoma
    chordoid glioma    gliosarcoma    plasma cell leukemia    liposarcoma

    8 diseases from the University of Copenhagen DISEASES database for CDK4:
    Retinoblastoma     Liposarcoma     Melanoma     Lipoma
    Malignant glioma     Carcinoma     Juxtacortical osteosarcoma     Breast cancer

    CDK4 for disorders           About GeneDecksing

    10/96 Novoseek inferred disease relationships for CDK4 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 91.8 191 10493518 (2), 9103470 (2), 7585516 (2), 9488660 (2) (see all 99)
    liposarcoma dedifferentiated 79.7 20 15221942 (4), 18214854 (2), 19737942 (2), 19946100 (2) (see all 13)
    liposarcoma 72 27 14694526 (4), 18820664 (3), 19626636 (2), 19823827 (2) (see all 16)
    tumors 71.5 390 17139501 (5), 9703873 (5), 16160477 (5), 12163365 (4) (see all 99)
    melanoma 70.4 240 8746340 (5), 9036865 (5), 9311594 (5), 17505264 (4) (see all 99)
    cancer 68 121 11756559 (4), 10398121 (3), 14648178 (2), 17481885 (2) (see all 89)
    glioblastoma 63.4 38 8806696 (4), 8811128 (4), 9600204 (3), 8586464 (2) (see all 17)
    multiple tumors 62.7 19 8821952 (2), 9827724 (1), 10094876 (1), 7744694 (1) (see all 18)
    anaplastic astrocytoma 58.7 3 7987821 (1), 16319692 (1), 9161727 (1)
    glioma 54.7 30 7585516 (3), 9815774 (3), 7954404 (2), 10587703 (2) (see all 19)

    Genetic Association Database (GAD): CDK4
    Human Genome Epidemiology (HuGE) Navigator: CDK4 (48 documents)
    Tumor Gene Database (TGDB): CDK4

    Export disorders for CDK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK4 gene, integrated from 9 sources (see all 1619):
    (articles sorted by number of sources associating them with CDK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. (PubMed id 19487459)1, 2, 9 Bockstaele L....Roger P.P. (2009)
    2. Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. (PubMed id 9425228)1, 2, 9 Soufir N.... Bressac-De Paillerets B. (1998)
    3. Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. (PubMed id 9311594)1, 2, 9 Guldberg P....Zeuthen J. (1997)
    4. Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. (PubMed id 16782892)1, 2, 9 Bockstaele L....Coulonval K. (2006)
    5. Crystal structure of human CDK4 in complex with a D-type cyclin. (PubMed id 19237565)1, 2, 9 Day P.J....Jhoti H. (2009)
    6. CDKN2A and CDK4 variants in Latvian melanoma patients: analysis of a clinic-based population. (PubMed id 17505264)1, 4, 9 Pjanova D....Heisele O. (2007)
    7. Chromosomal mapping of human CDK2, CDK4, and CDK5 cel l cycle kinase genes. (PubMed id 8275715)1, 3, 9 Demetrick D.J....Beach D.H. (1994)
    8. Genomic rearrangements of the CDKN2A locus are infrequent in Italian malignant melanoma families without evidence of CDKN2A/CDK4 point mutations. (PubMed id 19011513)1, 4, 9 Vignoli M....Genuardi M. (2008)
    9. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. (PubMed id 8221695)1, 2, 9 Khatib Z.A....Look A.T. (1993)
    10. Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. (PubMed id 18827403)1, 2, 9 Wang Z....Meng A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1019 HGNC: 1773 AceView: CDK4 Ensembl:ENSG00000135446 euGenes: HUgn1019
    ECgene: CDK4 Kegg: 1019 H-InvDB: CDK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK4 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CDK4
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK4 gene:
    Search GeneIP for patents involving CDK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for CDK4
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     Recombinant Protein for CDK4




     Proteins for CDK4
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     Search LifeMap BioReagents cell lines for CDK4
     Gene Synthesis
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     Variant Library Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK4
     SwitchGear 3'UTR luciferase reporter plasmids for CDK4
     SwitchGear Promoter luciferase reporter plasmids for CDK4
     ThermoFisher Antibody for CDK4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK4
    Customized:
     lentivirus for stable overexpression of CDK4
     lentivirus expression plasmids for stable overexpression of CDK4
     adenovirus for overexpression of CDK4
     LSBio Antibodies in human, mouse, rat for CDK4
    Customized transgenic rodents for:
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     Biomarker expression
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     Tissue-specific gene expresssion
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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