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CDK4 Gene

protein-coding GIFtS: 74

GC12M056428

cyclin-dependent kinase 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CMM3 ^², ⁵
EC 2.7.11.22 ^³
MGC14458 ^²
PSK-J3 ^¹, ², ³

Descriptions
cell division kinase 4 ^²
cyclin-dependent kinase 4 ^², ³
melanoma cutaneous malignant, 3 ^²

External Ids
HGNC: 1773¹
Entrez Gene: 1019²
UniProtKB: P11802³
Ensembl: ENSG00000135446⁷

Search outside databases for aliases for CDK4 gene

Previous GC identifers: GC12M057743 GC12M058284 GC12M057858

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDK4:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is

highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic

subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The

activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory

subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for

the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its

related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with

tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been

reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Function: Probably involved in the control of the cell cycle

Gene Wiki entry for CDK4 (Cyclin-dependent_kinase_4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDK4 gene

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13

CDK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M056428: (about GC identifiers)

Start:	56,428,270 bp from pter
End:	56,432,431 bp from pter
Size:	4,162 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802 (See protein sequence)

Recommended Name: Cell division protein kinase 4

Size: 303 amino acids; 33730 Da

Subunit: Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK

PDB structures from and Proteopedia :

1LD2 (3D)

2W96 (3D)

2W99 (3D)

2W9F (3D)

2W9Z (3D)

3G33 (3D)

Secondary accessions: O00576

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000066.1

ENSEMBL proteins:

ENSP00000316889 ENSP00000257904

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CDK4
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cdk4 + Cyclin D1, Cdks, Cdk4)
	Human Recombinant Proteins from Abnova (CDK4)

OriGene Purified Recombinant Human Protein: CDK4

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA	--
GO:0005634	nucleus	IDA	16109376
GO:0005654	nucleoplasm	EXP	9190208 16782892
GO:0005667	transcription factor complex	IEA	--
GO:0005829	cytosol	EXP	9106657

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Antibodies for CDK4:

	Invitrogen Antibodies for CDK4
	Millipore Mono- and Polyclonal Antibodies for the study of CDK4
	Sigma-Aldrich Antibody Arrays and Antibodies for CDK4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDK4
	Antibodies from Abcam (Cdk4 + Cyclin D1, Cdks, Cdk4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDK4)
	Novus Biologicals Antibodies for CDK4

Assays for CDK4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11802

ProtoNet protein and cluster: P11802

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK4)
		Millipore RNAi Products for the Analysis of CDK4 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000075

Applied Biosystems Silencer® siRNAs for CDK4

Sigma-Aldrich siRNA and siRNA Panels for CDK4

Sigma-Aldrich shRNA Panels and shRNA for CDK4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDK4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000075
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000075
untagged cDNA clones in CMV expression vector (see all 5): NM_000075

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000075

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Function: Probably involved in the control of the cell cycle

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Phosphorylation at Thr-172 is necessary for enzymatic activity (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.22

Genatlas biochemistry entry for CDK4:

cyclin dependent kinase 4 involved in cell cycle regulation (G1 to S transition),complexing with

cyclin D (D1,D2,D3),amplified in malignant glioblastoma and anaplastic astrocytoma,and in diffuse

large B cell lymphoma ; amplified in osteosarcoma with OS9,SAS and PRIM1and in sporadic breast

carcinomas,predisposing to familial melanoma by inducing abnormal repair of ultraviolet radiation.

Loss of CDK4 expression causes insulin deficient diabetes,and CDK4 activation results in B islet

cell hyperplasia in mice

15/21 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cdk4) (see all 21 ):

	behavior/neurological	cellular	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	muscle	nervous system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004693	cyclin-dependent protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	9106657 11896535 15232106 15558030 16169070 16326706 17274640 17353931 17517622
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for CDK4 (Your Favorite Gene powered by Ingenuity) (see all 14 )

Melanoma Signaling
Aryl Hydrocarbon Receptor Signaling
Molecular Mechanisms of Cancer
Tight Junction Signaling
Nicotinate and Nicotinamide Metabolism

GeneDecks CDK4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDK4

5/132 Interacting proteins for CDK4 (ENSP00000257904³ P11802^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 132 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCND2	P30279¹	STRING (score=.999) EBI-295644, EBI-748789
CDC37	Q16543¹	STRING (score=.999) EBI-295644, EBI-295634
CDKN2A	P42771¹	STRING (score=.999) EBI-295644, EBI-375053
CDKN2B	P42772¹	STRING (score=.999) EBI-295644, EBI-711280
CDKN2C	P42773¹	STRING (score=.999) EBI-295644, EBI-711290

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IMP	7603984
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007623	circadian rhythm	IEA	--
GO:0010468	regulation of gene expression	IMP	17420273

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CDK4

Sigma-Aldrich Small Molecules for CDK4:

Inhibitor

Compounds for CDK4 available from Tocris Bioscience

Compound	Action	CAS number
Ryuvidine	Cyclin-dependent kinase 4 (cdk4) inhibitor	[265312-55-8]
NSC 625987	Cyclin-dependent kinase 4 (cdk4) inhibitor	[141992-47-4]

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10/52 Novoseek chemical compound relationships for CDK4 gene (see all 52 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fascaplysin	84.43	12	10973815 (4), 16816972 (2), 16936279 (1), 16904725 (1) (see all 6)
nu6102	69.63	2	15928920 (2)
17-(allylamino)-17-demethoxygeldanamycin	63.78	4	18281495 (1), 18245548 (1), 18193424 (1), 17157164 (1)
imidazo[1,2-a]pyridine	42.32	1	12941325 (1)
thymidine	40.22	6	15665290 (1), 10432388 (1), 8622883 (1), 12153614 (1) (see all 6)
bromodeoxyuridine	36.49	3	8988060 (2), 15755480 (1)
pga2	30.47	7	8622677 (4), 8621603 (1)
threonine	28.91	12	10851085 (2), 17892862 (2), 12861061 (1), 18855578 (1) (see all 7)
apigenin	27.71	4	18656338 (1), 11299771 (1), 15620704 (1)
berberine	27.35	5	18379040 (1), 19189664 (1), 16621886 (1), 16505103 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK4)
		Millipore RNAi Products for the Analysis of CDK4 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000075

Sigma-Aldrich siRNA and siRNA Panels for CDK4

Sigma-Aldrich shRNA Panels and shRNA for CDK4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000075

REFSEQ mRNAs for CDK4 gene:

NM_000075.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000075

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000075
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000075
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_000075

Additional cDNA sequence:

AK297901.1 AK310724.1 AK313701.1 BC003644.2 BC005864.2 BC010153.2 BC015669.2 CR407668.1

CR542247.1 CR590586.1 CR591116.1 CR594194.1 CR597992.1 CR598582.1 CR602761.1 CR602927.1

CR608247.1 CR609991.1 CR616342.1 CR622282.1 M14505.1 U79269.1 Z48970.1

24/25 DOTS entries (see all 25 ):

DT.219465 DT.100851448 DT.92408932 DT.40113477 DT.100851457 DT.95222712 DT.97856917 DT.100851439

DT.121198842 DT.121198896 DT.95284131 DT.97789050 DT.121198761 DT.91928527 DT.100716609 DT.121198886

DT.40118681 DT.445603 DT.91772477 DT.91921800 DT.95339064 DT.95339068 DT.95339116 DT.97860433

24/974 AceView cDNA sequences (see all 974 ):

BU850002 AW298172 BF222951 BE905374 BM472703 BU165914 CB143270 CB160114

AI264566 BE383376 AW411404 AI674577 BI255420 AA356998 AI567341 BU943900

CR597992 BQ681906 F04615 BM458189 BQ232036 BU520905 AU104590 AA235586

highest scoring ESTs for CDK4:

AA315694 AA338741 AA339057 AA362679 AL546134 AL602986 AU117043 AW246398 AW410442 AW411404

Unigene Cluster for CDK4:

Cyclin-dependent kinase 4

Hs.95577 [show with all ESTs]

Unigene Representative Sequence: BM467999

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CDK4 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b
SP1:											-																-		-
SP2:											-														-				-
SP3:											-		-		-												-		-
SP4:											-		-		-		-										-		-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for CDK4

2 Ensembl transcripts including schematic representations:

ENST00000312990 ENST00000257904

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDK4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDK4

¹ / ² / ³

3 probe-sets matching CDK4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1942_s_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	U37022	0.20	1.00	0.72	1
202246_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	NM_000075	0.40	0.67	0.55	1
202246_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks CDK4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGGAAGAA

SOURCE GeneReport for Unigene cluster: Hs.95577
Expression variation in blood from EXPOLDB for CDK4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDK4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDK4¹	--	cyclin-dependent kinase 4	90.76(n) 97.03(a)	481131 XM_538252.2 XP_538252.1
chimpanzee (Pan troglodytes)	CDK4¹	--	cyclin-dependent kinase 4	99.89(n) 100(a)	452025 XM_509173.2 XP_509173.2
cow (Bos taurus)	CDK4¹	--	cyclin-dependent kinase 4	92.52(n) 97.03(a)	510618 NM_001037594.1 NP_001032683.1
rat (Rattus norvegicus)	Cdk4¹	--	cyclin-dependent kinase 4	87.9(n) 95.05(a)	94201 NM_053593.2 NP_446045.1
mouse (Mus musculus)	Cdk4^{1, 5}	10⁵	cyclin-dependent kinase 4^{1, 5}	88.12(n)¹ 94.72(a)¹	12567¹ NM_009870.2¹ NP_034000.1¹ AA791962⁵ AF223390⁵ (see all 26)

About this table Species with no ortholog for CDK4

ENSEMBL Gene Tree for CDK4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDK4 gene

CDK6² CCRK² CDK7²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/53 NCBI SNPs in CDK4 are shown (see all 53 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs238532^1,2	C,F,H	56432648(+)	`ACCCCC/TGCTGC`	1	--	ng3¹		8		EA NA NS EU WA	622
	rs3211607^1,2	C,F,H	56433043(-)	`TAGAAG/TACCCC`	1	--	ng3¹		10		NS EU EA WA MN CSAM	972
	rs2072052^1,2	C,F,H	56432986(+)	`CTGTCC/ACTGGC`	1	--	ng3¹		13		EA NS EU WA MN CSAM	2262
	rs2069500^1,2	C,F,H	56432464(-)	`GTGGCG/AGTCAC`	1	--	ng3¹		5		NA EA WA NS	634
	rs3211612^1,2	H	56431366(-)	`ATCCCG/AAACTG`	1	Q/R	mis¹ ese³		5		NS EU EA WA	594
--	rs3211606^1,2	F	56433152(-)	`GTGAGAG/-GATTA`	1	--	ng3¹		1		NS	154
	rs11547328^1,2	H	56431698(-)	`AGGCCC/TGTGAT`	1	R/C	mis¹ ese³		4		EU EA WA	406
	rs34386532^1,2	C	56431130(+)	`ACTGGC/TGCATC`	1	R/H	mis¹		4		EU EA WA	420
--	rs4986865^1,2	F	56432950(-)	`CATACA/TCACTG`	1	--	ng3¹		5		MN CSAM EA	408
--	rs11172321^1,2	C	56432721(+)	`GGCCAC/TCCAGA`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CDK4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123829 disorders: 609048

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

CDK4 mutations are involved in tumor formation

Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048,

155600]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a

preexisting benign nevus, which occurs most often in the skin but also may involve other sites

10/95 Novoseek disease relationships for CDK4 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	91.78	183	10493518 (2), 9103470 (2), 7585516 (2), 9488660 (2) (see all 99)
liposarcoma dedifferentiated	76.79	14	15221942 (4), 18214854 (2), 12640106 (1), 18204431 (1) (see all 9)
tumors	70.74	362	17139501 (5), 9703873 (5), 16160477 (5), 12163365 (4) (see all 99)
melanoma	70.33	227	8746340 (5), 9036865 (5), 9311594 (5), 17505264 (4) (see all 99)
liposarcoma	67.48	20	14694526 (4), 18820664 (3), 9713346 (2), 12640106 (1) (see all 11)
cancer	67.30	115	11756559 (4), 10398121 (3), 14648178 (2), 17481885 (2) (see all 85)
multiple tumors	62.68	18	8821952 (2), 9827724 (1), 10094876 (1), 7744694 (1) (see all 17)
glioblastoma	61.99	34	8806696 (4), 8811128 (4), 9600204 (3), 8586464 (2) (see all 14)
anaplastic astrocytoma	60.11	3	7987821 (1), 16319692 (1), 9161727 (1)
glioma	56.33	30	7585516 (3), 9815774 (3), 7954404 (2), 10587703 (2) (see all 19)

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Human Gene Mutation Database: CDK4
Genetic Association Database: CDK4
Human Genome Epidemiology Navigator: CDK4 (30 documents)
Tumor Gene Database: CDK4

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1329 PubMed articles for CDK4 gene (see all 1329 ):

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. (PubMed id 9425228)^{1, 3, 4} Soufir N.... Bressac-De Paillerets B. (1998)
Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. (PubMed id 9311594)^{1, 3, 4} Guldberg P....Zeuthen J. (1997)
Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PubMed id 8275715)^{1, 2, 3} Demetrick D.J....Beach D.H. (1994)
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. (PubMed id 8221695)^{1, 3, 4} Khatib Z.A....Look A.T. (1993)
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits. (PubMed id 15821902)^{1, 3, 6} Nielsen E.M....Pedersen O. (2005)
Role of the CDKN2A locus in patients with multiple primary melanomas. (PubMed id 15860862)^{1, 3, 6} Puig S....Mila M. (2005)
Absence of mutations in the CDKN2 binding site of CDK4 in childhood acute lymphoblastic leukemia. (PubMed id 11426564)^{1, 3, 6} Einsiedel H.G....Seeger K. (2001)
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. (PubMed id 8528263)^{1, 3, 4} Zuo L.... Dracopoli N.C. (1996)
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. (PubMed id 7652577)^{1, 3, 4} Wolfel T.... Beach D. (1995)
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)^{3, 4} Houlard M....Varin-Blank N. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1019	HGNC: 1773	AceView: CDK4	Ensembl:ENSG00000135446	euGenes: HUgn1019
ECgene: CDK4	H-InvDB: CDK4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDK4	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=CDK4
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdk4/

Licensable Technologies for CDK4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDK4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDK4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDK4		Antibodies for CDK4
	Explore super-pooled esiRNAs		Proteins for CDK4
	Lentivirus-delivered shRNAs for CDK4		Small molecules for CDK4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDK4)
	Antibodies (CDK4)
	Chimera RNAi (CDK4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDK4

	Recombinant Proteins (Cdk4 + Cyclin D1, Cdks, Cdk4)
	Antibodies (Cdk4 + Cyclin D1, Cdks, Cdk4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for CDK4

	Drugs for CDK4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDK4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDK4 Gene at Home site.
Version 2.41.1
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CDK4 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for CDK4

Summaries
for CDK4

Genomic Location
for CDK4

Proteins
for CDK4

Protein Domains/
Families
for CDK4

Gene Function
for CDK4

Pathways & Interactions
for CDK4

Drugs & Compounds
for CDK4

Transcripts
for CDK4

Expression
for CDK4

Orthologs
for CDK4

Paralogs
for CDK4

SNPs/Variants
for CDK4

Disorders & Mutations
for CDK4

Medical News
for CDK4

Publications
for CDK4

Search for CDK4

Genome Databases showing CDK4

Other Databases showing CDK4

Specialized Databases showing CDK4

Licensable Technologies
for CDK4

Services
for CDK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDK4 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor CDK4

Summariesfor CDK4

Genomic Locationfor CDK4

Proteinsfor CDK4

Protein Domains/Familiesfor CDK4

Gene Functionfor CDK4

Pathways & Interactionsfor CDK4

Drugs & Compoundsfor CDK4

Transcriptsfor CDK4

Expression for CDK4

Orthologsfor CDK4

Paralogsfor CDK4

SNPs/Variantsfor CDK4

Disorders & Mutationsfor CDK4

Medical Newsfor CDK4

Publicationsfor CDK4

Search for CDK4

Genome Databases showing CDK4

Other Databases showing CDK4

Specialized Databases showing CDK4

Licensable Technologiesfor CDK4

Servicesfor CDK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDK4

Summaries
for CDK4

Genomic Location
for CDK4

Proteins
for CDK4

Protein Domains/
Families
for CDK4

Gene Function
for CDK4

Pathways & Interactions
for CDK4

Drugs & Compounds
for CDK4

Transcripts
for CDK4

Expression
for CDK4

Orthologs
for CDK4

Paralogs
for CDK4

SNPs/Variants
for CDK4

Disorders & Mutations
for CDK4

Medical News
for CDK4

Publications
for CDK4

Licensable Technologies
for CDK4

Services
for CDK4