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Aliases for CDK4 Gene

Aliases for CDK4 Gene

  • Cyclin Dependent Kinase 4 2 3 5
  • Cell Division Protein Kinase 4 3 4
  • EC 2.7.11.22 4 61
  • PSK-J3 3 4
  • Cyclin-Dependent Kinase 4 3
  • EC 2.7.11 61
  • CMM3 3

External Ids for CDK4 Gene

Previous GeneCards Identifiers for CDK4 Gene

  • GC12M058284
  • GC12M057858
  • GC12M056428
  • GC12M058142
  • GC12M055178

Summaries for CDK4 Gene

Entrez Gene Summary for CDK4 Gene

  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

CIViC summary for CDK4 Gene

  • CDK4, along with its partner CDK6, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors.

GeneCards Summary for CDK4 Gene

CDK4 (Cyclin Dependent Kinase 4) is a Protein Coding gene. Diseases associated with CDK4 include Melanoma, Cutaneous Malignant, 3 and Cdk4-Related Cutaneous Malignant Melanoma. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and Meiosis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK6.

UniProtKB/Swiss-Prot for CDK4 Gene

  • Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Tocris Summary for CDK4 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK4 Gene

Genomics for CDK4 Gene

Regulatory Elements for CDK4 Gene

Enhancers for CDK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057863 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -108.9 -108906 2.6 ATF1 SIN3A GLIS2 FOS DEK SP3 REST SMARCB1 SMARCA4 GLIS1 EEF1AKMT3 MIR26A2 CDK4 AVIL RNU6-1083P TSFM METTL1 CYP27B1 MARCH9 CTDSP2
GH12G057905 1.6 Ensembl ENCODE dbSUPER 9.4 -149.6 -149617 0.9 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 DEK ZNF263 ZHX2 MXD4 ATP23 MIR26A2 RNU6-1083P CTDSP2 AVIL TSFM CYP27B1 EEF1AKMT3 METTL1 CDK4
GH12G057868 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 -113.4 -113354 2.0 PKNOX1 POLR2A SMARCA4 SCRT2 KLF17 FOXP2 ZBTB8A EEF1AKMT3 AVIL CTDSP2 MIR26A2 TSFM METTL1 CYP27B1 RNU6-1083P CDK4 MARCH9
GH12G057830 2 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -83.5 -83467 17.0 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 EEF1AKMT3 TSFM ATP23 METTL1 CTDSP2 TSPAN31 CDK4 AGAP2 LOC283387 PIR34053
GH12G057861 0.9 ENCODE 9.7 -105.7 -105720 0.2 HDAC1 PKNOX1 ATF1 ARNT SIN3A BMI1 GATA2 FOS RCOR1 CREM MIR26A2 AVIL RNU6-1083P TSFM METTL1 CYP27B1 EEF1AKMT3 CDK4 MARCH9 CTDSP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK4 on UCSC Golden Path with GeneCards custom track

Promoters for CDK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000268635 513 1401 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B FOS ZNF548 SP3 SP5

Genomic Location for CDK4 Gene

Chromosome:
12
Start:
57,747,727 bp from pter
End:
57,756,013 bp from pter
Size:
8,287 bases
Orientation:
Minus strand

Genomic View for CDK4 Gene

Genes around CDK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK4 Gene

Proteins for CDK4 Gene

  • Protein details for CDK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11802-CDK4_HUMAN
    Recommended name:
    Cyclin-dependent kinase 4
    Protein Accession:
    P11802
    Secondary Accessions:
    • B2R9A0
    • B4DNF9
    • O00576
    • Q6FG61

    Protein attributes for CDK4 Gene

    Size:
    303 amino acids
    Molecular mass:
    33730 Da
    Quaternary structure:
    • Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on Tyr-88 and Tyr-89); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Interacts with CEBPA (when phosphorylated) (PubMed:15107404). Interacts with FNIP1 and FNIP2 (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for CDK4 Gene

    Alternative splice isoforms for CDK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK4 Gene

Selected DME Specific Peptides for CDK4 Gene

P11802:
  • GCIFAEM
  • RKPLFCGNSEADQL
  • WSVGCIFAE
  • ETIKDLM
  • YEPVAEIGVGAYGTVYKARD
  • QMALTPVVVTLWYRAPEVLLQSTYATPVD
  • TLVFEHVDQDL
  • VKLADFG
  • HPNVVRL
  • VVTLWYR
  • ENILVTS
  • WSVGCIFAEMFRRKPLF
  • LADFGLA
  • RDLKPEN
  • KRISAFRALQHSYLHK
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for CDK4 Gene

  • Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
  • Ubiquitination at posLast=2222, Lys35, posLast=106106, posLast=155155, posLast=211211, Lys282, and Lys297
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK4 (CDK4)
  • Abcam antibodies for CDK4

Protein Products

  • Abcam proteins for CDK4

Domains & Families for CDK4 Gene

Gene Families for CDK4 Gene

Protein Domains for CDK4 Gene

Graphical View of Domain Structure for InterPro Entry

P11802

UniProtKB/Swiss-Prot:

CDK4_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK4: view

Function for CDK4 Gene

Molecular function for CDK4 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 4 involved in cell cycle regulation (G1 to S transition),complexing with cyclin D (D1,D2,D3),amplified in malignant glioblastoma and anaplastic astrocytoma,and in diffuse large B cell lymphoma ; amplified in osteosarcoma with OS9,SAS and PRIM1and in sporadic breast carcinomas,predisposing to familial melanoma by inducing abnormal repair of ultraviolet radiation. Loss of CDK4 expression causes insulin deficient diabetes,and CDK4 activation results in B islet cell hyperplasia in mice
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequennt activation.
UniProtKB/Swiss-Prot Function:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Enzyme Numbers (IUBMB) for CDK4 Gene

Gene Ontology (GO) - Molecular Function for CDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA 8114739
GO:0005515 protein binding IPI 7568034
genes like me logo Genes that share ontologies with CDK4: view
genes like me logo Genes that share phenotypes with CDK4: view

Human Phenotype Ontology for CDK4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDK4 Gene

MGI Knock Outs for CDK4:

Animal Model Products

CRISPR Products

miRNA for CDK4 Gene

miRTarBase miRNAs that target CDK4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK4
  • Applied Biological Materials Clones for CDK4

No data available for Transcription Factor Targets and HOMER Transcription for CDK4 Gene

Localization for CDK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK4 Gene

Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK4 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 17420273
GO:0000785 chromatin IDA 18827403
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with CDK4: view

Pathways & Interactions for CDK4 Gene

genes like me logo Genes that share pathways with CDK4: view

SIGNOR curated interactions for CDK4 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 7603984
GO:0002088 lens development in camera-type eye IEA --
GO:0006468 protein phosphorylation IDA,IEA 8114739
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with CDK4: view

Drugs & Compounds for CDK4 Gene

(149) Drugs for CDK4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palbociclib Approved Pharma Inhibition, Target, Inhibitor 127
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1318
Ribociclib Approved Pharma Target, antagonist, inhibitor 0
Somatropin recombinant Approved, Investigational Pharma 0
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Aromatase Inhibitors, Hormone therapy, Potent aromatase (CYP19) inhibitor 279

(44) Additional Compounds for CDK4 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PD 0332991 isethionate
827022-33-3

(5) Tocris Compounds for CDK4 Gene

Compound Action Cas Number
BMS 265246 Potent cdk1/2 inhibitor 582315-72-8
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 142273-20-9
PD 0332991 isethionate Potent, selective Cdk4/6 inhibitor; brain penetrant 827022-33-3
Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor 872573-93-8
Senexin A Cyclin-dependent kinase 8 (cdk8) inhibitor

(22) ApexBio Compounds for CDK4 Gene

Compound Action Cas Number
[Ala92]-p16 (84-103) 189064-08-2
AMG 925 FLT3/CDK4 inhibitor,potent and selective 1401033-86-0
AT7519 Multi-CDK inhibitor 844442-38-2
BS-181 HCl CDK7 inhibitor,highly selective 1397219-81-6
CDK4 inhibitor CDK4/Cyclin D1 inhibitor 1256963-02-6
Flavopiridol hydrochloride 131740-09-5
LDC000067 1073485-20-7
LEE011 CDK4/6 inhibitor 1211441-98-3
LEE011 hydrochloride CDK inhibitor 1211443-80-9
LEE011 succinate CDK inhibitor 1374639-75-4
LEE011 succinate hydrate CDK inhibitor 1374639-79-8
LY2835219 CDK4/6 inhibitor,potent and selective 1231930-82-7
LY2835219 free base CDK inhibitor 1231929-97-7
NSC 625987 141992-47-4
P276-00 CDK-1/CDK4/CDK9 inhibitor 920113-03-7
Palbociclib (PD0332991) Isethionate CDK4/6 inhibitor,highly selective 827022-33-3
PD 0332991 (Palbociclib) HCl CDK4/6 inhibitor,highly selective 827022-32-2
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol A 212844-53-6
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ryuvidine 265312-55-8
genes like me logo Genes that share compounds with CDK4: view

Drug Products

Transcripts for CDK4 Gene

Unigene Clusters for CDK4 Gene

Cyclin-dependent kinase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK4
  • Applied Biological Materials Clones for CDK4

Alternative Splicing Database (ASD) splice patterns (SP) for CDK4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7:
SP8: - -
SP9:

Relevant External Links for CDK4 Gene

GeneLoc Exon Structure for
CDK4
ECgene alternative splicing isoforms for
CDK4

Expression for CDK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK4 Gene

Protein differential expression in normal tissues from HIPED for CDK4 Gene

This gene is overexpressed in Uterus (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK4 Gene



Protein tissue co-expression partners for CDK4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK4 Gene:

CDK4

SOURCE GeneReport for Unigene cluster for CDK4 Gene:

Hs.95577

Evidence on tissue expression from TISSUES for CDK4 Gene

  • Muscle(4.9)
  • Nervous system(4.6)
  • Skin(4.3)
  • Lung(4)
  • Intestine(3.8)
  • Kidney(3.1)
  • Liver(3.1)
  • Pancreas(3)
  • Blood(2.9)
  • Bone marrow(2.6)
  • Eye(2.6)
  • Heart(2.5)
  • Lymph node(2.5)
  • Stomach(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK4 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • lymphatic
  • nervous
Organs:
Head and neck:
  • brain
  • eye
  • head
General:
  • skin
genes like me logo Genes that share expression patterns with CDK4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK4 Gene

Orthologs for CDK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK4 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia CDK4 34 35
  • 92.52 (n)
-- 35
  • 88 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDK4 34 35
  • 90.76 (n)
mouse
(Mus musculus)
Mammalia Cdk4 34 16 35
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Cdk4 34
  • 87.9 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CDK4 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk4 34
  • 71.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52574 34
zebrafish
(Danio rerio)
Actinopterygii cdk4 34 35
  • 68.28 (n)
Dr.14474 34
fruit fly
(Drosophila melanogaster)
Insecta Cdk4 36 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-4 36 35
  • 42 (a)
F52B5.2 35
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3270 34
Species where no ortholog for CDK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK4 Gene

ENSEMBL:
Gene Tree for CDK4 (if available)
TreeFam:
Gene Tree for CDK4 (if available)

Paralogs for CDK4 Gene

Paralogs for CDK4 Gene

Pseudogenes.org Pseudogenes for CDK4 Gene

genes like me logo Genes that share paralogs with CDK4: view

Variants for CDK4 Gene

Sequence variations from dbSNP and Humsavar for CDK4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs104894340 other, Melanoma, cutaneous malignant 3 (CMM3) [MIM:609048] 57,751,647(-) GGCCC(A/G)TGATC reference, missense
rs11547328 Pathogenic, Melanoma, cutaneous malignant 3 (CMM3) [MIM:609048] 57,751,648(-) AGGCC(C/T)GTGAT reference, missense
rs144890720 Uncertain significance, Melanoma, cutaneous malignant 3 (CMM3) [MIM:609048] 57,751,596(+) CTCCA(C/T)TGGGG reference, missense
rs786203016 Pathogenic 57,750,968(-) GACTT(-/T)GGCCT reference, frameshift-variant
rs113625101 Likely benign 57,748,004(+) CCCAA(C/T)GTGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK4 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv826384 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for CDK4 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK4 Gene

Human Gene Mutation Database (HGMD)
CDK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK4 Gene

Disorders for CDK4 Gene

MalaCards: The human disease database

(76) MalaCards diseases for CDK4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma, cutaneous malignant, 3
  • melanoma, cutaneous malignant 3
cdk4-related cutaneous malignant melanoma
  • cmm3
dedifferentiated liposarcoma
  • ddls
astrocytoma
  • astrocytic tumor
atypical lipomatous tumor
  • liposarcoma, well differentiated
- elite association - COSMIC cancer census association via MalaCards
Search CDK4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK4_HUMAN
  • Melanoma, cutaneous malignant 3 (CMM3) [MIM:609048]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:7652577, ECO:0000269 PubMed:8528263, ECO:0000269 PubMed:9311594, ECO:0000269 PubMed:9425228}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CDK4

Genetic Association Database (GAD)
CDK4
Human Genome Epidemiology (HuGE) Navigator
CDK4
Tumor Gene Database (TGDB):
CDK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK4
genes like me logo Genes that share disorders with CDK4: view

No data available for Genatlas for CDK4 Gene

Publications for CDK4 Gene

  1. Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. (PMID: 19487459) Bockstaele L. … Roger P.P. (Mol. Cell. Biol. 2009) 3 4 22 64
  2. Crystal structure of human CDK4 in complex with a D-type cyclin. (PMID: 19237565) Day P.J. … Jhoti H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 22 64
  3. Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. (PMID: 16782892) Bockstaele L. … Coulonval K. (Mol. Cell. Biol. 2006) 3 4 22 64
  4. Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits. (PMID: 15821902) Nielsen E.M. … Pedersen O. (J. Mol. Med. 2005) 3 22 46 64
  5. Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. (PMID: 9311594) Guldberg P. … Zeuthen J. (Int. J. Cancer 1997) 3 4 22 64

Products for CDK4 Gene

  • Addgene plasmids for CDK4

Sources for CDK4 Gene

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