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Aliases for CDK3 Gene

Aliases for CDK3 Gene

  • Cyclin-Dependent Kinase 3 2 3
  • EC 2.7.11.22 4 63
  • Cell Division Protein Kinase 3 4
  • EC 2.7.11 63
  • CDKN3 4

External Ids for CDK3 Gene

Previous GeneCards Identifiers for CDK3 Gene

  • GC17M073921
  • GC17P077001
  • GC17P074439
  • GC17P074572
  • GC17P074594
  • GC17P071486
  • GC17P073977
  • GC17P069422
  • GC17P073996

Summaries for CDK3 Gene

Entrez Gene Summary for CDK3 Gene

  • This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK3 Gene

CDK3 (Cyclin-Dependent Kinase 3) is a Protein Coding gene. Among its related pathways are Cell Cycle Control of Chromosomal Replication and GADD45 Pathway. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK1.

UniProtKB/Swiss-Prot for CDK3 Gene

  • Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Gene Wiki entry for CDK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK3 Gene

Genomics for CDK3 Gene

Regulatory Elements for CDK3 Gene

Genomic Location for CDK3 Gene

Start:
76,000,906 bp from pter
End:
76,005,999 bp from pter
Size:
5,094 bases
Orientation:
Plus strand

Genomic View for CDK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK3 Gene

Proteins for CDK3 Gene

  • Protein details for CDK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00526-CDK3_HUMAN
    Recommended name:
    Cyclin-dependent kinase 3
    Protein Accession:
    Q00526
    Secondary Accessions:

    Protein attributes for CDK3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35046 Da
    Quaternary structure:
    • Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CDK3 Gene

neXtProt entry for CDK3 Gene

Proteomics data for CDK3 Gene at MOPED

Post-translational modifications for CDK3 Gene

  • Ubiquitination at Lys9
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CDK3 Gene

Gene Families for CDK3 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00526

UniProtKB/Swiss-Prot:

CDK3_HUMAN :
  • Q00526
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK3: view

Function for CDK3 Gene

Molecular function for CDK3 Gene

GENATLAS Biochemistry: cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Enzyme Numbers (IUBMB) for CDK3 Gene

Gene Ontology (GO) - Molecular Function for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK3: view

Phenotypes for CDK3 Gene

genes like me logo Genes that share phenotypes with CDK3: view

Animal Model Products

CRISPR Products

miRNA for CDK3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK3 Gene

Localization for CDK3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CDK3 Gene

Pathways for CDK3 Gene

genes like me logo Genes that share pathways with CDK3: view

Pathways by source for CDK3 Gene

Interacting Proteins for CDK3 Gene

Gene Ontology (GO) - Biological Process for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8846921
GO:0006468 protein phosphorylation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008283 cell proliferation TAS 18794154
GO:0045023 G0 to G1 transition TAS 15084261
genes like me logo Genes that share ontologies with CDK3: view

Compounds for CDK3 Gene

(2) HMDB Compounds for CDK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with CDK3: view

Transcripts for CDK3 Gene

mRNA/cDNA for CDK3 Gene

(138) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK3 Gene

Cyclin-dependent kinase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CDK3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK3 Gene

No ASD Table

Relevant External Links for CDK3 Gene

GeneLoc Exon Structure for
CDK3
ECgene alternative splicing isoforms for
CDK3

Expression for CDK3 Gene

mRNA expression in normal human tissues for CDK3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDK3 Gene

SOURCE GeneReport for Unigene cluster for CDK3 Gene Hs.706766

mRNA Expression by UniProt/SwissProt for CDK3 Gene

Q00526-CDK3_HUMAN
Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue.
genes like me logo Genes that share expressions with CDK3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK3 Gene

Orthologs for CDK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK3 35
  • 99.78 (n)
  • 99.67 (a)
CDK3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK3 35
  • 88.89 (n)
  • 89.11 (a)
CDK3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK3 35
  • 90.1 (n)
  • 91.72 (a)
CDK3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk3-ps 16
Cdk3-ps 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK3 35
  • 75.67 (n)
  • 81.33 (a)
CDK3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK3 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-57f11.1 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta cdc2c 36
  • 59 (a)
OneToMany
cdc2c 37
  • 65 (a)
cdc2 37
  • 65 (a)
Cdk4 37
  • 45 (a)
CG6800 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-4 37
  • 36 (a)
cdk-1 37
  • 63 (a)
H01G02.2 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 36
  • 62 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.13118 35
wheat
(Triticum aestivum)
Liliopsida Ta.6675 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5702 36
  • 64 (a)
OneToMany
Species with no ortholog for CDK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for CDK3 Gene

ENSEMBL:
Gene Tree for CDK3 (if available)
TreeFam:
Gene Tree for CDK3 (if available)

Paralogs for CDK3 Gene

Paralogs for CDK3 Gene

genes like me logo Genes that share paralogs with CDK3: view

Variants for CDK3 Gene

Sequence variations from dbSNP and Humsavar for CDK3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_021101 -
VAR_021102 -
VAR_041973 A glioblastoma multiforme sample
VAR_041974 -
VAR_041975 -

Structural Variations from Database of Genomic Variants (DGV) for CDK3 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv908825 CNV Loss 21882294
nsv908826 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294

Relevant External Links for CDK3 Gene

HapMap Linkage Disequilibrium report
CDK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK3 Gene

Disorders for CDK3 Gene

(2) Novoseek inferred disease relationships for CDK3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
cancer 0 2
genes like me logo Genes that share disorders with CDK3: view

No data available for UniProtKB/Swiss-Prot for CDK3 Gene

Publications for CDK3 Gene

  1. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 2 3 4 23
  2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PMID: 18794154) Zheng D. … Dong Z. (Cancer Res. 2008) 3 4 23
  3. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PMID: 11733001) Yamochi T. … Matsuoka M. (Eur. J. Biochem. 2001) 3 23
  4. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PMID: 7882308) Bullrich F. … Croce C.M. (Cancer Res. 1995) 3 23
  5. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PMID: 8242750) Gyuris J. … Brent R. (Cell 1993) 3 23

Products for CDK3 Gene

  • Addgene plasmids for CDK3

Sources for CDK3 Gene

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